Ferrari, Ana Lya Moya, Piculo dos Santos, Aline Darc, Bertolaccini, Guilherme da Silva, Medola, Fausto Orsi, and Sandnes, Frode Eika
Ferrari, A.L.M., Piculo dos Santos, A.D., Bertolaccini, G.S., Medola, F.O. & Sandnes, F.E. (2020). Evaluation of orthosis rapid prototyping during the design process: Analysis of verification models. In: M. Di Nicolantonio, E. Rossi & T. Alexander (Eds.), Advances in additive manufacturing, modeling systems and 3D prototyping: Proceedings of the AHFE 2019 International Conference on Additive Manufacturing, Modeling Systems and 3D Prototyping, Cham: Springer (pp. 298-307)
Usó, Vanessa Ghiraldeli, Sandnes, Frode Eika, and Medola, Fausto Orsi
Usó, V.G., Sandnes, F.E. & Medola, F.O. (2020). Using virtual reality and rapid prototyping to co-create together with hospitalized children. In: M. Di Nicolantonio, E. Rossi & T. Alexander (Eds.). Advances in additive manufacturing, modeling systems and 3D prototyping: Proceedings of the AHFE 2019 International Conference on Additive Manufacturing, Modeling Systems and 3D Prototyping, 2020 (pp. 279-288) Cham: Springer
Bryden, Douglas (Designer), author. and Bryden, Douglas (Designer), author.
Industrial design -- Computer-aided design -- Case studies., Product design -- Computer-aided design -- Case studies., Computer-aided design., Rapid prototyping., Industrial design -- Data processing -- Case studies., Industrial design -- Data processing., and Case studies.
Computer-aided design (CAD) and rapid prototyping (RP) are now a fundamental part of the professional practice of product design and are therefore essential skills for product design undergraduate students. This book provides students with all the tools needed to get to grips with the range of both CAD software and RP processes used in the industry.
RAPID prototyping, SELECTIVE laser sintering, DENTISTRY, and STEREOLITHOGRAPHY
The advent of Rapid prototyping has opened new prospects in medical field, especially dentistry with its accuracy and speed. Rapid prototyping is an additive manufacturing technology that produces prototype models by adding materials, layer by layer. The earlier subtractive technologies manufactured objects via milling or grinding of a material resulting in replication of only external surface details. On the contrary, rapid prototyping provides a replica with internal complex shapes. This article discusses the various Rapid prototyping technologies commonly employed in dentistry such as selective laser sintering, stereolithography, fused deposition modelling. inkjet printing and solid ground curing. [ABSTRACT FROM AUTHOR]
Karim AS, Dudley QM, Juminaga A, Yuan Y, Crowe SA, Heggestad JT, Garg S, Abdalla T, Grubbe WS, Rasor BJ, Coar DN, Torculas M, Krein M, Liew FE, Quattlebaum A, Jensen RO, Stuart JA, Simpson SD, Köpke M, and Jewett MC
Nature chemical biology [Nat Chem Biol] 2020 Jun 15. Date of Electronic Publication: 2020 Jun 15.
The design and optimization of biosynthetic pathways for industrially relevant, non-model organisms is challenging due to transformation idiosyncrasies, reduced numbers of validated genetic parts and a lack of high-throughput workflows. Here we describe a platform for in vitro prototyping and rapid optimization of biosynthetic enzymes (iPROBE) to accelerate this process. In iPROBE, cell lysates are enriched with biosynthetic enzymes by cell-free protein synthesis and then metabolic pathways are assembled in a mix-and-match fashion to assess pathway performance. We demonstrate iPROBE by screening 54 different cell-free pathways for 3-hydroxybutyrate production and optimizing a six-step butanol pathway across 205 permutations using data-driven design. Observing a strong correlation (r = 0.79) between cell-free and cellular performance, we then scaled up our highest-performing pathway, which improved in vivo 3-HB production in Clostridium by 20-fold to 14.63 ± 0.48 g l -1 . We expect iPROBE to accelerate design-build-test cycles for industrial biotechnology.
Geronazzo M, Vieira LS, Nilsson NC, Udesen J, and Serafin S
IEEE transactions on visualization and computer graphics [IEEE Trans Vis Comput Graph] 2020 May; Vol. 26 (5), pp. 1912-1922. Date of Electronic Publication: 2020 Feb 13.
Directivity and gain in microphone array systems for hearing aids or hearable devices allow users to acoustically enhance the information of a source of interest. This source is usually positioned directly in front. This feature is called acoustic beamforming. The current study aimed to improve users' interactions with beamforming via a virtual prototyping approach in immersive virtual environments (VEs). Eighteen participants took part in experimental sessions composed of a calibration procedure and a selective auditory attention voice-pairing task. Eight concurrent speakers were placed in an anechoic environment in two virtual reality (VR) scenarios. The scenarios were a purely virtual scenario and a realistic 360° audio-visual recording. Participants were asked to find an individual optimal parameterization for three different virtual beamformers: (i) head-guided, (ii) eye gaze-guided, and (iii) a novel interaction technique called dual beamformer, where head-guided is combined with an additional hand-guided beamformer. None of the participants were able to complete the task without a virtual beamformer (i.e., in normal hearing condition) due to the high complexity introduced by the experimental design. However, participants were able to correctly pair all speakers using all three proposed interaction metaphors. Providing superhuman hearing abilities in the form of a dual acoustic beamformer guided by head and hand movements resulted in statistically significant improvements in terms of pairing time, suggesting the task-relevance of interacting with multiple points of interests.
Haller, Norm, author. and National Research Council (U.S.). Air Force Studies Board, issuing body.
Prototypes, Engineering -- Congresses., Rapid prototyping -- Congresses., and Military research -- United States -- Planning -- Congresses.
"Assessment to Enhance Air Force and Department of Defense Prototyping for the New Defense Strategy is the summary of a workshop convened by the Air Force Studies Board of the National Academies' National Research Council in September 2013 to enhance Air Force and Department of Defense (DoD) prototyping for the new defense strategy. This workshop examined of a wide range of prototyping issues, including individual recommendations for a renewed prototype program, application of prototyping as a tool for technology/system development and sustainment (including annual funding), and positive and negative effects of a renewed program. Prototyping has historically been of great benefit to the Air Force and DoD in terms of risk reduction and concept demonstration prior to system development, advancing new technologies, workforce enhancement and skills continuity between major acquisitions, dissuasion of adversaries by demonstrating capabilities, maintaining technological surprise through classified technologies, and an overarching strategy of overall risk reduction during austere budget environments. Over the last two decades, however, many issues with prototyping have arisen. For example, the definitions and terminology associated with prototyping have been convoluted and budgets for prototyping have been used as offsets to remedy budget shortfalls. Additionally, prototyping has been done with no strategic intent or context, and both government and industry have misused prototyping as a key tool in the DoD and defense industrial base. Assessment to Enhance Air Force and Department of Defense Prototyping for the New Defense Strategy envisions a prototyping program that encourages innovation in new concepts and approaches and provides a means to assess and reduce risk before commitment to major new programs."--Publisher's description.
TRASTUZUMAB, DOCETAXEL, RAPID prototyping, IMMUNOGLOBULINS, NANOPARTICLES, and FLOW cytometry
Developing targeted nanoparticles is a rising strategy to improve drug delivery in oncology. Antibodies are the most commonly used targeting agents. However, determination of their optimal number at the surface remains a challenging issue, mainly due to the difficulties in measuring precisely surface coating levels when prototyping nanoparticles. We developed an original quantitative assay to measure the exact number of coated antibodies per nanoparticle. Using flow cytometry optimized for submicron particle analysis and beads covered with known amounts of human IgG-kappa mimicking various amounts of antibodies, this new method was tested as part of the prototyping of docetaxel liposomes coated with trastuzumab against Her2+ breast cancer. This quantification method allowed to discriminate various batches of immunoliposomes depending on their trastuzumab density on nanoparticle surface (i.e., 330 (Immunoliposome-1), 480 (Immunoliposome-2) and 690 (Immunoliposome-3), p = 0.004, One-way ANOVA). Here we showed that optimal number of grafted antibodies on nanoparticles should be finely tuned and highest density of targeting agent is not necessarily associated with highest efficacy. Overall, this new method should help to better prototype third generation nanoparticles. [ABSTRACT FROM AUTHOR]
VIRTUAL prototypes, VIRTUAL design, HUMAN-machine systems, MACHINERY, TASK performance, RAPID prototyping, and MOBILE robots
Limited visibility from a mobile machine cab can decrease task performance and lead to accidents. Therefore, it is important to consider visibility issues already in the design phase. This paper describes the use of virtual prototyping in the evaluation of see-through features of mobile work machines. The goal is to evaluate whether two different machine boom transparency levels have an effect on task performance. In addition, two alternative placements of overlaid information in the operators' field of view are assessed. A within-subject design was used in this study. Based on the results, there was no significant difference in performance between the transparency levels. However, the test participants preferred a transparency level of 70–80% (where 0% is completely opaque). Similar results were found with the placement of the overlaid information, which had no significant effect on task performance. Both placements, on the windscreen and on the tunnel wall, were equally favoured by the participants. The findings of this study contribute to the design of see-through features for mobile work machines. In addition, the study demonstrates the use of virtual prototyping in the design of novel features in human–machine systems. [ABSTRACT FROM AUTHOR]
Gibson, I. (Ian), Rosen, D. W. (David W.), Stucker, B. (Brent), and Gibson, I. (Ian)
Manufacturing processes -- Automation., Production control -- Automation., CAD/CAM systems., and Rapid Prototyping (Fertigung)
"Additive Manufacturing Technologies: Rapid Prototyping to Direct Digital Manufacturing deals with various aspects of joining materials to form parts. Additive Manufacturing (AM) is an automated technique for direct conversion of 3D CAD data into physical objects using a variety of approaches. Manufacturers have been using these technologies in order to reduce development cycle times and get their products to the market quicker, more cost effectively, and with added value due to the incorporation of customizable features. Realizing the potential of AM applications, a large number of processes have been developed allowing the use of various materials ranging from plastics to metals for product development. Authors Ian Gibson, David W. Rosen and Brent Stucker explain these issues, as well as: Providing a comprehensive overview of AM technologies plus descriptions of support technologies like software systems and post-processing approaches ; Discussing the wide variety of new and emerging applications like micro-scale AM, medical applications, direct write electronics and Direct Digital Manufacturing of end-use components ; Introducing systematic solutions for process selection and design for AM. Additive Manufacturing Technologies: Rapid Prototyping to Direct Digital Manufacturing is the perfect book for researchers, students, practicing engineers, entrepreneurs, and manufacturing industry professionals interested in additive manufacturing."--Publisher's website.