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OZERNYI, DANIIL M.
- Journal of Linguistics; Feb2023, Vol. 59 Issue 1, p219-223, 5p
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SECOND language acquisition, DOMINANT language, CHINESE language, LANGUAGE & languages, NATIVE language, and NATURAL languages
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And even though I do not think that most domain-general models of L SB 1 sb /L SB 2 sb acquisition are going to come under further scrutiny, Mazuka's distinction is likely to be valuable for domain-specific models of acquisition (of phonology). Yes, L SB 2 sb learners do not parse de-RCs in the same way as native speakers do, but that only indicates that they have not achieved ultimate attainment; not that there are fundamental differences in L SB 1 sb and L SB 2 sb processing. Martohardjono, Valian and Klein (MVK) take up the deficit and transfer accounts (d/t) of L SB 2 sb acquisition in their chapter, while looking at acquisition of tense. [Extracted from the article]
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2. Continuity and change in the evolution of French yes-no questions: A cross-variety perspective. [2022]
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Comeau, Philip, King, Ruth, and LeBlanc, Carmen L.
- Diachronica; 2022, Vol. 39 Issue 5, p616-657, 42p
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FRENCH language, SOCIOLINGUISTICS, CONTINUITY, CANADIAN history, and TECHNOLOGICAL innovations
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Copyright of Diachronica is the property of John Benjamins Publishing Co. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Alencar, Mery I. G. de, Belo, André Y. S. P., Silva, José L. A., Asato, Ana E. B., Gomes, Eduarda F., de Oliveira, Valéria S., Teixeira, Jesiel de O., Monte, Otávio de S., Mota, Adriano S., Pereira, Vitória M. L., Dantas, Sibele S., Silva, Gabriel H. S., Goto, Bruno T., Souza, Alexandre F., and Caliman, Adriano
- Journal of Tropical Ecology; Nov2022, Vol. 38 Issue 6, p462-471, 10p
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The home-field advantage (HFA) hypothesis establishes that plant litter decomposes faster at 'home' sites than in 'away' sites due to more specialized decomposers acting at home sites. This hypothesis has predominantly been tested through 'yes or no' transplanting experiments, where the litter decomposition of a focal species is quantified near and away from their conspecifics. Herein, we evaluated the occurrence and magnitude of home-field effects on the leaf litter decomposition of Myrcia ramuliflora (O.Berg) N. Silveira (Myrtaceae) along a natural gradient of conspecific litterfall input and also if home-field effects are affected by litter and soil traits. Litter decomposition of M. ramuliflora was assessed through litterbags placed in 39 plots in a tropical heath vegetation over a period of 12 months. We also characterized abiotic factors, litter layer traits, and litter diversity. Our results indicated the occurrence of positive (i.e. Home-field advantage) and negative (i.e. Home-field disadvantage) effects in more than half of the plots. Positive and negative effects occurred in a similar frequency and magnitude. Among all predictors tested, only the community weighted mean C/N ratio of the litterfall input was associated with home-field effects. Our results reinforce the lack of generality for home-field effects found in the literature and thus challenge the understanding of litter-decomposer interaction in tropical ecosystems. [ABSTRACT FROM AUTHOR]
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Guerra Sierra, Beatriz E., Arteaga-Figueroa, Luis A., Sierra-Pelaéz, Susana, and Alvarez, Javier C.
- Journal of Fungi; Oct2022, Vol. 8 Issue 10, p1042-N.PAG, 18p
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TALAROMYCES, CACAO, FUNGAL growth, NATURAL resources, SOIL pollution, and SOILS
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Inorganic pollutants in Colombian cocoa (Theobroma cacao L.) agrosystems cause problems in the production, quality, and exportation of this raw material worldwide. There has been an increased interest in bioprospecting studies of different fungal species focused on the biosorption of heavy metals. Furthermore, fungi constitute a valuable, profitable, ecological, and efficient natural soil resource that could be considered in the integrated management of cadmium mitigation. This study reports a new species of Talaromyces isolated from a cocoa soil sample collected in San Vicente de Chucurí, Colombia. T. santanderensis is featured by Lemon Yellow (R. Pl. IV) mycelium on CYA, mono-to-biverticillade conidiophores, and acerose phialides. T. santanderensis is distinguished from related species by its growth rate on CYAS and powdery textures on MEA, YES and OA, high acid production on CREA and smaller conidia. It is differentiated from T. lentulus by its growth rate on CYA medium at 37 °C without exudate production, its cream (R. PI. XVI) margin on MEA, and dense sporulation on YES and CYA. Phylogenetic analysis was performed using a polyphasic approach, including different phylogenetic analyses of combined and individual ITS, CaM, BenA, and RPB2 gene sequences that indicate that it is new to science and is named Talaromyces santanderensis sp. nov. This new species belongs to the Talaromyces section and is closely related to T. lentulus, T. soli, T. tumuli, and T. pratensis (inside the T. pinophilus species complex) in the inferred phylogeny. Mycelia growth of the fungal strains was subjected to a range of 0–400 mg/kg Cd and incorporated into malt extract agar (MEA) in triplicates. Fungal radial growth was recorded every three days over a 13-day incubation period and In vitro cadmium tolerance tests showed a high tolerance index (0.81) when the mycelium was exposed to 300 mg/kg of Cd. Results suggest that T. santanderensis showed tolerance to Cd concentrations that exceed the permissible limits for contaminated soils, and it is promising for its use in bioremediation strategies to eliminate Cd from highly contaminated agricultural soils. [ABSTRACT FROM AUTHOR]
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Gili, Juan Antonio, López‐Camelo, Jorge Santiago, Nembhard, Wendy N., Bakker, Marian, de Walle, Hermien E. K., Stallings, Erin B., Kancherla, Vijaya, Contiero, Paolo, Dastgiri, Saeed, Feldkamp, Marcia L., Nance, Amy, Gatt, Miriam, Martínez, Laura, Canessa, María Aurora, Groisman, Boris, Hurtado‐Villa, Paula, Källén, Karin, Landau, Danielle, Lelong, Nathalie, and Morgan, Margery
- Birth Defects Research; Jul2022, Vol. 114 Issue 12, p631-644, 14p
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Background: Congenital hydrocephalus (CH) comprises a heterogeneous group of birth anomalies with a wide‐ranging prevalence across geographic regions and registry type. The aim of the present study was to analyze the early neonatal case fatality rate (CFR) and total birth prevalence of newborns diagnosed with CH. Methods: Data were provided by 25 registries from four continents participating in the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR) on births ascertained between 2000 and 2014. Two CH rates were calculated using a Poisson distribution: early neonatal CFR (death within 7 days) per 100 liveborn CH cases (CFR) and total birth prevalence rate (BPR) per 10,000 births (including live births and stillbirths) (BPR). Heterogeneity between registries was calculated using a meta‐analysis approach with random effects. Temporal trends in CFR and BPR within registries were evaluated through Poisson regression modeling. Results: A total of 13,112 CH cases among 19,293,280 total births were analyzed. The early neonatal CFR was 5.9 per 100 liveborn cases, 95% confidence interval (CI): 5.4–6.8. The CFR among syndromic cases was 2.7 times (95% CI: 2.2–3.3) higher than among non‐syndromic cases (10.4% [95% CI: 9.3–11.7] and 4.4% [95% CI: 3.7–5.2], respectively). The total BPR was 6.8 per 10,000 births (95% CI: 6.7–6.9). Stratified by elective termination of pregnancy for fetal anomalies (ETOPFA), region and system, higher CFR were observed alongside higher BPR rates. The early neonatal CFR and total BPR did not show temporal variation, with the exception of a CFR decrease in one registry. Conclusions: Findings of early neonatal CFR and total BPR were highly heterogeneous among registries participating in ICBDSR. Most registries with higher CFR also had higher BPR. Differences were attributable to type of registry (hospital‐based vs. population‐based), ETOPFA (allowed yes or no) and geographical regions. These findings contribute to the understanding of regional differences of CH occurrence and early neonatal deaths. [ABSTRACT FROM AUTHOR]
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Symons, Rebecca A., Colella, Fabio, Collins, Fraser L., Rafipay, Alexandra J., Kania, Karolina, McClure, Jessica J., White, Nathan, Cunningham, Iain, Ashraf, Sadaf, Hay, Elizabeth, Mackenzie, Kevin S., Howard, Kenneth A., Riemen, Anna H. K., Manzo, Antonio, Clark, Susan M., Roelofs, Anke J., Bari, Cosimo De, and De Bari, Cosimo
- Annals of the Rheumatic Diseases; Feb2022, Vol. 81 Issue 2, p214-224, 11p
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Objective: We aimed to understand the role of the transcriptional co-factor Yes-associated protein (Yap) in the molecular pathway underpinning the pathogenic transformation of synovial fibroblasts (SF) in rheumatoid arthritis (RA) to become invasive and cause joint destruction.Methods: Synovium from patients with RA and mice with antigen-induced arthritis (AIA) was analysed by immunostaining and qRT-PCR. SF were targeted using Pdgfrα-CreER and Gdf5-Cre mice, crossed with fluorescent reporters for cell tracing and Yap-flox mice for conditional Yap ablation. Fibroblast phenotypes were analysed by flow cytometry, and arthritis severity was assessed by histology. Yap activation was detected using Yap-Tead reporter cells and Yap-Snail interaction by proximity ligation assay. SF invasiveness was analysed using matrigel-coated transwells.Results: Yap, its binding partner Snail and downstream target connective tissue growth factor were upregulated in hyperplastic human RA and in mouse AIA synovium, with Yap detected in SF but not macrophages. Lineage tracing showed polyclonal expansion of Pdgfrα-expressing SF during AIA, with predominant expansion of the Gdf5-lineage SF subpopulation descending from the embryonic joint interzone. Gdf5-lineage SF showed increased expression of Yap and adopted an erosive phenotype (podoplanin+Thy-1 cell surface antigen-), invading cartilage and bone. Conditional ablation of Yap in Gdf5-lineage cells or Pdgfrα-expressing fibroblasts ameliorated AIA. Interleukin (IL)-6, but not tumour necrosis factor alpha (TNF-α) or IL-1β, Jak-dependently activated Yap and induced Yap-Snail interaction. SF invasiveness induced by IL-6 stimulation or Snail overexpression was prevented by Yap knockdown, showing a critical role for Yap in SF transformation in RA.Conclusions: Our findings uncover the IL-6-Yap-Snail signalling axis in pathogenic SF in inflammatory arthritis. [ABSTRACT FROM AUTHOR]
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López-López, Edgar, Fernández-de Gortari, Eli, and Medina-Franco, José L.
- Drug discovery today. 27(8):2353-2362
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Asrani, Kaushal, Torres, Alba FC, Woo, Juhyung, Vidotto, Thiago, Tsai, Harrison K, Luo, Jun, Corey, Eva, Hanratty, Brian, Coleman, Ilsa, Yegnasubramanian, Srinivasan, De Marzo, Angelo M, Nelson, Peter S, Haffner, Michael C, and Lotan, Tamara L
- Journal of Pathology; Dec2021, Vol. 255 Issue 4, p425-437, 13p
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PROSTATE cancer, ANDROGEN deprivation therapy, LABORATORY mice, CANCER genes, TRANSCRIPTION factors, and DIAGNOSIS
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Neuroendocrine prostate cancer (NEPC) is a rare but aggressive histologic variant of prostate cancer that responds poorly to androgen deprivation therapy. Hybrid NEPC‐adenocarcinoma (AdCa) tumors are common, often eluding accurate pathologic diagnosis and requiring ancillary markers for classification. We recently performed an outlier‐based meta‐analysis across a number of independent gene expression microarray datasets to identify novel markers that differentiate NEPC from AdCa, including up‐regulation of insulinoma‐associated protein 1 (INSM1) and loss of Yes‐associated protein 1 (YAP1). Here, using diverse cancer gene expression datasets, we show that Hippo pathway‐related genes, including YAP1, are among the top down‐regulated gene sets with expression of the neuroendocrine transcription factors, including INSM1. In prostate cancer cell lines, transgenic mouse models, and human prostate tumor cohorts, we confirm that YAP1 RNA and YAP1 protein expression are silenced in NEPC and demonstrate that the inverse correlation of INSM1 and YAP1 expression helps to distinguish AdCa from NEPC. Mechanistically, we find that YAP1 loss in NEPC may help to maintain INSM1 expression in prostate cancer cell lines and we further demonstrate that YAP1 silencing likely occurs epigenetically, via CpG hypermethylation near its transcriptional start site. Taken together, these data nominate two additional markers to distinguish NEPC from AdCa and add to data from other tumor types suggesting that Hippo signaling is tightly reciprocally regulated with neuroendocrine transcription factor expression. © 2021 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
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9. Differences in characteristics between people with tinnitus that seek help and that do not. [2021]
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Rademaker, M. M., Stegeman, I., Brabers, A. E. M., de Jong, J. D., Stokroos, R. J., and Smit, A. L.
- Scientific Reports; 11/25/2021, Vol. 11 Issue 1, p1-13, 13p
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HELP-seeking behavior, TINNITUS, and HEARING disorders
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Knowledge on characteristics of people that seek help for tinnitus is scarce. The primary objective of this study was to describe differences in characteristics between people with tinnitus that seek help compared to those who do not seek help. Next, we described differences in characteristics between those with and without tinnitus. In this cross-sectional study, we sent a questionnaire on characteristics in different domains; demographic, tinnitus-specific, general- and psychological health, auditory and noise- and substance behaviour. We assessed if participants had sought help or planned to seek help for tinnitus. Tinnitus distress was defined with the Tinnitus Functional Index. Differences between groups (help seeking: yes/no, tinnitus: yes/no) were described. 932 people took part in our survey. Two hundred and sixteen participants were defined as having tinnitus (23.2%). Seventy-three of those sought or planned to seek help. A constant tinnitus pattern, a varying tinnitus loudness, and hearing loss, were described more frequently in help seekers. Help seekers reported higher TFI scores. Differences between help seekers and people not seeking help were mainly identified in tinnitus- and audiological characteristics. These outcomes might function as a foundation to explore the heterogeneity in tinnitus patients. [ABSTRACT FROM AUTHOR]
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DE OLIVEIRA SILVA, DANILO, TABORDA, BIANCA, PAZZINATTO, MARCELLA F., ARDERN, CLARE L., and BARTON, CHRISTIAN J.
- Journal of Orthopaedic & Sports Physical Therapy; Nov2021, Vol. 51 Issue 11, p536-541, 6p
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SPORTS sciences, CROSS-sectional method, SERIAL publications, SOCIAL media, MULTIPLE regression analysis, REGRESSION analysis, CITATION analysis, OPEN access publishing, DESCRIPTIVE statistics, PERIODICAL articles, DATA analysis software, and IMPACT factor (Citation analysis)
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*OBJECTIVE: To assess the relationship of individual article citations in the sport sciences field with (1) Journal Impact Factor, (2) each article's open access status, and (3) Altmetric score components. * DESIGN: Cross-sectional. * METHODS: We searched the Web of Science Journal Citation Reports database in the sport sciences category for the 20 journals with the highest 2-year Journal Impact Factor in 2018. We extracted the impact factor for each journal and each article's open access status (yes or no). Between September 2019 and February 2020, we obtained individual citations, Altmetric scores, and details of Altmetric components (eg, number of tweets, Face-book posts, etc) for each article published in 2017. Linear and multiple regression models were used to assess the relationship between the dependent variable (citation number) and the independent variables (article Altmetric score and open access status and Journal Impact Factor). *RESULTS: Of the 4022 articles included, the total Altmetric score, Journal Impact Factor, and open access status respectively explained 32%, 14%, and 1% of the variance in article citations (when combined, the variables explained 40% of the variance in article citations). The number of tweets related to an article was the Altmetric component that explained the highest proportion of article citations (37%). *CONCLUSION: Altmetric scores in sport sciences journals have a stronger relationship with number of citations than Journal Impact Factor and open access status do. Twitter may be the best social media platform for promoting a research article. [ABSTRACT FROM AUTHOR]
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Farias Santos, Fernanda de, da Silva, Igor Jean Moura, Gomes, Dharliton Soares, and de Amorim Santos, Israel Gomes
- Diversitas Journal; 2021, Vol. 6 Issue 4, p3882-3889, 8p
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Copyright of Diversitas Journal is the property of Diversitas Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Donkel, Samantha J., Wolters, Frank J., Ikram, M. Arfan, and de Maat, Moniek P. M.
- PLoS ONE; 8/11/2021, p1-13, 13p
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CARDIOVASCULAR diseases risk factors, MYELOPEROXIDASE, CORONARY disease, CARDIOVASCULAR diseases, CIRCULATING tumor DNA, and HDL cholesterol
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Introduction: Neutrophil extracellular traps (NETs) are DNA scaffolds enriched with antimicrobial proteins. NETs have been implicated in the development of various diseases, such as cardiovascular disease. Here, we investigate the association of demographic and cardiovascular (CVD) risk factors with NETs in the general population. Material and methods: Citrated plasma was collected from 6449 participants, aged ≥55 years, as part of the prospective population-based Rotterdam Study. NETs were quantified by measuring MPO-DNA complex using an ELISA. We used linear regression to determine the associations between MPO-DNA complex and age, sex, cardio-metabolic risk factors, and plasma markers of inflammation and coagulation. Results: MPO-DNA complex levels were weakly associated with age (log difference per 10 year increase: -0.04 mAU/mL, 95% confidence interval [CI] -0.06;-0.02), a history of coronary heart disease (yes versus no: -0.10 mAU/mL, 95% CI -0.17;-0.03), the use of lipid-lowering drugs (yes versus no: -0.06 mAU/mL, 95% CI -0.12;-0.01), and HDL-cholesterol (per mmol/l increase: -0.07 mAU/mL/, 95% CI -0.12;-0.03). Conclusions: Older age, a history of coronary heart disease, the use of lipid-lowering drugs and higher HDL-cholesterol are weakly correlated with lower plasma levels of NETs. These findings show that the effect of CVD risk factors on NETs levels in a general population is only small and may not be of clinical relevance. This supports that NETs may play a more important role in an acute phase of disease than in a steady state situation. [ABSTRACT FROM AUTHOR]
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van Baar, H., Bours, M. J. L., Beijer, S., van Zutphen, M., van Duijnhoven, F. J. B., Kok, D. E., Wesselink, E., de Wilt, J. H. W., Kampman, E., and Winkels, R. M.
- Journal of Cancer Survivorship; Aug2021, Vol. 15 Issue 4, p597-606, 10p
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Purpose: Persistent fatigue among colorectal cancer (CRC) patients might be associated with unfavorable body composition, but data are sparse and inconsistent. We studied how skeletal muscle index (SMI), skeletal muscle radiodensity (SMR), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) at diagnosis are associated with fatigue up to 24 months post-diagnosis in stage I–III CRC patients. Methods: SMI, SMR, VAT, and SAT were assessed among 646 CRC patients using pre-treatment computed tomography images. Fatigue at diagnosis, at 6, and 24 months post-diagnosis was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. The association of SMI, SMR, VAT, and SAT with fatigue (yes/no) was assessed using confounder-adjusted restricted cubic spline analyses. Results: Prevalence of fatigue at diagnosis was 18%, at 6 months 25%, and at 24 months 12%. At diagnosis, a significant (p = 0.01) non-linear association of higher levels of SAT with higher prevalence of fatigue was observed. Lower levels of SMR were linearly associated with higher prevalence of fatigue at 6 months post-diagnosis (overall association p = 0.02). None of the body composition parameters were significantly associated with fatigue at 24 months. Conclusion: Having more SAT was associated with more fatigue at diagnosis, while low levels of SMR were associated with more fatigue at 6 months post-diagnosis. Implications for Cancer Survivors: Our results suggest that it may be interesting to investigate whether interventions that aim to increase SMR around the time of diagnosis may help to lower fatigue. However, more knowledge is needed to understand the mechanisms behind the association of SMR with fatigue. [ABSTRACT FROM AUTHOR]
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Kaczmarek, Bożydar L. J. and Gaś, Zbigniew B.
- Acta Neuropsychologica; 2021, Vol. 19 Issue 3, p319-328, 10p
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SELF-deception, COVID-19, PSYCHOLOGICAL well-being, COVID-19 pandemic, SOCIAL attitudes, FEAR, and ATTITUDE (Psychology)
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Background: Poland's inhabitants have often expressed disbelief and negative attitudes toward social isolation, combined with restlessness. This is due to a tendency to discount troubling informa tion while facing the unknown and counter-argue against information that causes discomfort and fear. This tendency helps humans to maintain hope and well-being. The study aimed to determine if Polish citizens tend to downplay or even deny danger when faced with a death threat. Material/Methods: The study comprised 58 adults - 46 females 12 males, aged 21 to 49. The participants were asked to answer 12 questions defining their beliefs and attitudes towards the COVID-19 pandemic threat and its consequences. The subjects gave answers on the 5-point Likert scale, from "definitely not" to "de finitely yes". Results: The findings of the present study show that a considerable number of the participants tend to exhibit an optimistic bias. This is reflected in their direct statements and in the lack of congruence of their opinions. They do feel the threat of becoming ill but also seem to believe it need not affect them personally. They are also relatively optimistic about the outcomes of the pandemic. At the same time, they realize that COVID-19 may lead to severe psychological, neurological, and mental disorders. Conclusions: The study confirmed a tendency to deny the threat that can pose a severe risk to health and psychological well-being. This is a manifestation of an optimism bias that has its roots in the way the human brain works. The participants did express concerns about the future but at the same time hoped that life after the pandemic would return to normal. It reflects a benevolent facet of self-deception since it makes it possible to cope with highly threatening and impossible to control events. [ABSTRACT FROM AUTHOR]
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Møller, Cleide Oliveira de Almeida, Freire, Luisa, Rosim, Roice Eliana, Margalho, Larissa Pereira, Balthazar, Celso Fasura, Franco, Larissa Tuanny, Sant'Ana, Anderson de Souza, Corassin, Carlos Humberto, Rattray, Fergal Patrick, and Oliveira, Carlos Augusto Fernandes de
- Frontiers in Microbiology; 4/22/2021, Vol. 11, pN.PAG-N.PAG, 18p
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AFLATOXINS, ASPERGILLUS flavus, LACTIC acid bacteria, ASPERGILLUS parasiticus, COMPETITION (Biology), ZEARALENONE, and POTASSIUM phosphates
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The increased consumption of plant-based foods has intensified the concern related to mycotoxin intoxication. This study aimed to investigate the effect of selected lactic acid bacteria (LAB) strains on the growth of Aspergillus parasiticus NRRL 2999 and its production of aflatoxin (AF). The ability of the heat-killed (100°C for 1 h) LAB strains to bind aflatoxin M1 (AFM1) in milk and aflatoxin B1 (AFB1), ochratoxin A (OTA), and zearalenone (ZEN) in potassium phosphate buffer (PPB) was also evaluated in vitro. Ten LAB strains were tested individually, by inoculating them simultaneously with the fungus or after incubation of the fungus for 24 or 48 h at 25°C. Double layer yeast extract sucrose (YES) agar, de Man Rogosa and Sharpe (MRS) agar, and YES broth were incubated for 7 days at 25°C to follow the development of the fungus. Levilactobacillus spp. 3QB398 and Levilactobacillus brevis 2QB422 strains were able to delay the growth of A. parasiticus in YES broth, even when these strains were inoculated 24 h after the fungus. The inhibitory effect of these LAB strains was confirmed by the reduction of fungus colony size, suggesting dominance of LAB by competition (a Lotka-Voltera effect). The production of AFB1 by A. parasiticus was inhibited when the fungus was inoculated simultaneously with Lactiplantibacillus plantarum 3QB361 or L. plantarum 3QB350. No AFB1 was found when Levilactobacillus spp. 2QB383 was present, even when the LAB was inoculated 48 h after the fungus. In binding studies, seven inactivated LAB strains were able to promote a reduction of at least 50% the level of AFB1, OTA, and ZEN. This reduction varied depending on the pH of the PPB. In milk, however, only two inactivated LAB strains were able to reduce AFM1, with a reduction of 33 and 45% for Levilactobacillus spp. 3QB398 (Levilactobacillus spp.) and L. brevis 2QB422, respectively. Nevertheless, these results clearly indicate the potential of using LAB for mycotoxin reduction. [ABSTRACT FROM AUTHOR]
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Borrelli, Silvio, De Nicola, Luca, Minutolo, Roberto, Conte, Giuseppe, Chiodini, Paolo, Cupisti, Adamasco, Santoro, Domenico, Calabrese, Vincenzo, Giannese, Domenico, Garofalo, Carlo, Provenzano, Michele, Bellizzi, Vincenzo, Apicella, Luca, Piccoli, Giorgina Barbara, Torreggiani, Massimo, Di Iorio, Biagio Raffaele, and Liakopoulos, Vassilios
- Nutrients; Mar2021, Vol. 13 Issue 3, p942, 1p
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Background: No study has explored the limitations of current long-term management of hyperkalemia (HK) in outpatient CKD clinics. Methods: We evaluated the association between current therapeutic options and control of serum K (sK) during 12-month follow up in ND-CKD patients stratified in four groups by HK (sK ≥ 5.0 mEq/L) at baseline and month 12: Absent (no-no), Resolving (yes-no), New Onset (no-yes), Persistent (yes-yes). Results: We studied 562 patients (age 66.2 ± 14.5 y; 61% males; eGFR 39.8 ± 21.8 mL/min/1.73 m2, RAASI 76.2%). HK was "absent" in 50.7%, "resolving" in 15.6%, "new onset" in 16.6%, and "persistent" in 17.1%. Twenty-four hour urinary measurements testified adherence to nutritional recommendations in the four groups at either visit. We detected increased prescription from baseline to month 12 of bicarbonate supplements (from 5.0 to 14.1%, p < 0.0001), K-binders (from 2.0 to 7.7%, p < 0.0001), and non-K sparing diuretics (from 34.3 to 41.5%, p < 0.001); these changes were consistent across groups. Similar results were obtained when using higher sK level (≥5.5 mEq/L) to stratify patients. Mixed-effects regression analysis showed that higher sK over time was associated with eGFR < 60, diabetes, lower serum bicarbonate, lower use of non-K sparing diuretics, bicarbonate supplementation, and K-binder use. Treatment-by-time interaction showed that sK decreased in HK patients given bicarbonate (p = 0.003) and K-binders (p = 0.005). Conclusions: This observational study discloses that one-third of ND-CKD patients under nephrology care remain with or develop HK during a 12-month period despite low K intake and increased use of sK-lowering drugs. [ABSTRACT FROM AUTHOR]
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Crocker, J. C., Farrar, N., Cook, J. A., Treweek, S., Woolfall, K., Chant, A., Bostock, J., Locock, L., Rees, S., Olszowski, S., and Bulbulia, R.
- BJS Open; Dec2020, Vol. 4 Issue 6, p1238-1245, 8p
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NURSES, PHYSICIANS, and CLINICAL trials
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Copyright of BJS Open is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Xia, Lily L. L. and Ma, Joyce L. C.
- Family Process; Dec2020, Vol. 59 Issue 4, p1914-1927, 14p, 3 Charts
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ATTITUDE (Psychology), CULTURE, EXPERIENTIAL learning, FAMILY psychotherapy, HOSPITAL medical staff, INTERPROFESSIONAL relations, INTERVIEWING, MEDICAL personnel, PROFESSIONS, SELF-efficacy, SUPERVISION of employees, PEER relations, and THEMATIC analysis
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Copyright of Family Process is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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19. Oncology Nurse plus Peer Navigation: A Promising Model for Hispanic/Latina Women with Breast Cancer. [2020]
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Saavedra Ferrer, E. L., Hine, W. L., Arellano, S. L., Ortega de Corona, P., Cardenas, M. C., and Vicuna Tellez, B.
- Journal of Oncology Navigation & Survivorship; Nov2020, Vol. 11 Issue 11, p402-403, 2p
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BREAST tumors, ONCOLOGY nursing, CONFERENCES & conventions, HISPANIC Americans, NURSES, AFFINITY groups, OCCUPATIONAL roles, and SOCIAL support
- Abstract
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Background: Breast cancer is the most common cancer among New Mexico Hispanic women, and Hispanic women are less likely to be diagnosed with early-stage cancer compared with Anglo women.1 Hispanic/Latina women have lower mammography screening rates for breast cancer compared with Anglo women.2 Breast cancer screening disparities are persistent among Hispanic/Latina women. The Comadre a Comadre Program is a multilevel, community-based, peer-led, culturally and linguistically competent intervention designed to improve the breast health and breast cancer outcomes among Hispanic/ Latina women in New Mexico. It is important to explore the effectiveness of tailored navigation models for specific populations and settings. Oncology nurse navigation in cancer care is a vital component of patient care. The nurse navigator serves as a clinical resource with expertise in oncology care management.3-7 Underserved women with cancer face additional barriers, which are outside the domain of the medical facility setting and the clinical aspects of cancer. These barriers, or social determinants of health, can be cultural (eg, privacy norms that discourage discussion about their bodies), logistical (eg, transportation to hospitals), language-based (eg, lack of understanding despite the use of medical interpreters), and emotionally based (eg, a fatalistic view of cancer).8 Community-based peer navigation, when implemented in conjunction with clinic-based oncology nurse navigation, could be a promising navigation model.9-12 Objectives: * To examine the types of practical, structural, and nonclinical support provided to the women by lay peer navigators (community-based) * To examine the clinical aspects of the role of the oncology nurse navigator in this cancer setting * To examine the characteristics of women who most benefited from navigation efforts Method: Peer navigators completed 2 different types of tracking data forms following individual encounters with participants. The Clinic Tracking and the Non-Clinic Tracking forms are used when the peer navigator either meets the participant at the clinic for her medical appointment (clinic form) or conducts other navigation on her behalf, either face-to-face or by telephone (non-clinic form). The forms track dichotomous variables, recorded by checking yes or no on the form. The Clinic Tracking form variables include providing emotional support at the medical appointment, accessing types of cancer services (medical language interpreter, social worker, etc). The Non-Clinic Tracking form variables include advocacy, program support, navigation to other agencies, and follow-up with the patient. Participants also complete a project-developed demographic survey. Quantitative data collected from peer navigators (tracking form data and demographic data) for the period 2018 to 2020 will be the focus of the analysis. Five to 10 encounters per woman, for 100 women, will be analyzed. The oncology nurse navigator completes referral forms for participants in the program. Reason( s) provided for referrals will be examined qualitatively, analyzing emergent themes and core competencies of oncology nurse and lay patient navigators. Results: Results from this analysis will include demographic data that include variables such as income, self-identify, education, etc. In an earlier analysis (2014) of the Comadre Program, we found emotional support, financial navigation, and language access to be the most frequent types of support provided by the navigators. We anticipate we will find similar patterns in these data. We are currently in the final stages of analysis for the period of 2018 to 2020. Conclusion: The findings gleaned from this analysis will show that the types of support provided by these 2 navigator types (lay and nurse oncology navigation) can work in a complementary manner and be effective in improving cancer care for Hispanic/Latina women. [ABSTRACT FROM AUTHOR]
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Geijsen, Anne J M R, Ulvik, Arve, Gigic, Biljana, Kok, Dieuwertje E, Duijnhoven, Fränzel J B van, Holowatyj, Andreana N, Brezina, Stefanie, Roekel, Eline H van, Baierl, Andreas, Bergmann, Michael M, Böhm, Jürgen, Bours, Martijn J L, Brenner, Hermann, Breukink, Stéphanie O, Bronner, Mary P, Chang-Claude, Jenny, Wilt, Johannes H W de, Grady, William M, Grünberger, Thomas, and Gumpenberger, Tanja
- JNCI Cancer Spectrum; Oct2020, Vol. 4 Issue 5, p1-11, 11p
- Subjects
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FOLIC acid, COLON cancer, CARCINOGENESIS, COLON cancer patients, and PROPORTIONAL hazards models
- Abstract
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Background Folates, including folic acid, may play a dual role in colorectal cancer development. Folate is suggested to be protective in early carcinogenesis but could accelerate growth of premalignant lesions or micrometastases. Whether circulating concentrations of folate and folic acid, measured around time of diagnosis, are associated with recurrence and survival in colorectal cancer patients is largely unknown. Methods Circulating concentrations of folate, folic acid, and folate catabolites p-aminobenzoylglutamate and p-acetamidobenzoylglutamate were measured by liquid chromatography-tandem mass spectrometry at diagnosis in 2024 stage I-III colorectal cancer patients from European and US patient cohort studies. Multivariable-adjusted Cox proportional hazard models were used to assess associations between folate, folic acid, and folate catabolites concentrations with recurrence, overall survival, and disease-free survival. Results No statistically significant associations were observed between folate, p-aminobenzoylglutamate, and p-acetamidobenzoylglutamate concentrations and recurrence, overall survival, and disease-free survival, with hazard ratios ranging from 0.92 to 1.16. The detection of folic acid in the circulation (yes or no) was not associated with any outcome. However, among patients with detectable folic acid concentrations (n = 296), a higher risk of recurrence was observed for each twofold increase in folic acid (hazard ratio = 1.31, 95% confidence interval = 1.02 to 1.58). No statistically significant associations were found between folic acid concentrations and overall and disease-free survival. Conclusions Circulating folate and folate catabolite concentrations at colorectal cancer diagnosis were not associated with recurrence and survival. However, caution is warranted for high blood concentrations of folic acid because they may increase the risk of colorectal cancer recurrence. [ABSTRACT FROM AUTHOR]
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