articles+ search results

Public Health, Environmental and Occupational Health, Nutrition and Dietetics, and Food Science

Background: The Ketogenic diet has gained popularity, especially among college students in the past few years, mainly as a strategy for fast weight losse but due to lack of appropriate knowledge of ketogenic diet plan might affect their overall health. Therefore, the present study was designed to evaluate knowledge and perception about ketogenic diet among students of three different faculties of Northern Border University, Arar, KSA. Methods: The present study had a cross sectional study design and a total of 303 (214 female and 89 males) students were contacted between 15 February and 20 March, 2021. A self-administered online (Google form) questionnaire was used to investigate socio-demographic data as well as student’s knowledge and perception about the ketogenic diet. Results: The majority of the participants, 197 (65%) know that ketogenic diet compise of high fat, moderate protein, and low carbohydrate. The main therapeutic aim for adopting a ketogenic diet was weight loss for 153 participants (50.3%), whereas 115 (38%) of them adopted it for treating poly cystic ovary (PCOD) and only 84 (27. 7%) for controlling diabetes. The source of knowledge about the ketogenic diet was primarily social media 199 (65.9%), and only 82 (27.2%) adopted it after consultation from a dietitian. However, 72 particiants (23.8%) believed that the ketogenic diet did not have any adverse effects on the human body. Conclusion: The result of the present study indicates that students had convincing knowledge and perception about the ketogenic diet as well as its therapeutic uses. However, pre-diet counseling is imperative for everyone to know every aspect and correct technique for carrying out this diet.

removable partial dentures, complete dentures, phonetics, awareness, dental students, and dental education

Phonetics plays a major role in the fabrication of prostheses. This study aimed to assess the knowledge of students regarding the role of phonetics in denture fabrication and to improve the educational process and the clinical application. The study was conducted at the College of Dentistry, Imam Abdulrahman Bin Faisal University, and involved a survey of 344 dental students and interns. The questionnaire contained 20 questions and was divided into three sections: general knowledge, clinical correlations, and clinical evaluations. The data were collected and analyzed statistically using independent t-tests, one-way ANOVA, and Tukey’s post hoc tests. The response rate was 100%. Male and female students only differed significantly in terms of their scores for answers to general knowledge questions, with females achieving better results (p = 0.023). General knowledge varied significantly between fourth-year students and all other levels (p < 0.001), and fifth-year students and interns (p = 0.027). The clinical correlations varied significantly between fourth-year students and interns (p = 0.01), whereas the clinical evaluations varied between all the academic years and interns (fourth-year, p < 0.001; fifth-year, p = 0.003; and sixth-year, p = 0.017). The interns obtained the highest scores in all sections. There was a lack of awareness among dental students of some aspects of the role of phonetics in denture fabrication. The study highlights the deficiencies that need to be addressed and the need for adjustments to the curriculum related to removable prosthodontics in order to improve the knowledge of students regarding the role of speech in denture fabrication.

Ophthalmology and General Medicine

Background Acute annular outer retinopathy (AAOR) is an uncommon disease. To date, there are few documented cases in the literature. Our case report is the first to describe a case of acute annular outer retinopathy in a patient with invasive ductal breast carcinoma. Case presentation The patient presented with photopsias and visual loss approximately 3 weeks prior to a diagnosis of invasive ductal breast carcinoma. We have documented the outer annular white ring seen in the acute phase of this disease and correlate it anatomically with Spectral-domain optical coherence tomography (SD-OCT) imaging. We identified RPE atrophy with nodular hyperreflectivity and loss of ellipsoid layer within the white annular ring with corresponding visual field loss. Fundus autofluorescence correlated with structural alterations seen on SD-OCT and showed both presumed active hyperautofluorescent zones with patchy hypoautofluorescent zones of atrophy and a classic annular hyperautofluorescent border. This case provides additional information about the natural history of this rare entity and its prognosis and varied presentation. Conclusions The authors report a single case of acute annular outer retinopathy in a patient with invasive ductal breast carcinoma with the corresponding SD-OCT, fundus autofluorescence and visual field findings, during the acute phase of the disease. These findings provide new insight into the characteristic features, etiology and progression of this rare disease.

General Medicine

Gastroenterology and Hepatology

History and Philosophy of Science and Social Sciences (miscellaneous)

Pulmonary and Respiratory Medicine

Background: Several studies have demonstrated gender influence on asthma prevalence, being higher among males during early childhood. Little is known about the impact of gender and age on asthma exacerbation characteristics in pediatrics. This study aimed to determine the differences in acute asthma between males and females in three different age groups regarding perinatal characteristics of asthmatic patients, comorbidities, medication adherence, level of blood eosinophils, and pattern of hospitalization.Methods: The medical records of 130 pediatric patients with asthma, who presented to the emergency department at Jordan University hospital with asthma exacerbations, were retrospectively reviewed. Demographic information and clinical characteristics were collected.Results: The mean age of patients was 10.7±4.7 years. The age at diagnosis and gestational age were significantly higher in older children. Furthermore, younger children were significantly more likely to experience winter exacerbations and more emergency presentations. Male patients were considerably younger than their female counterparts and were diagnosed younger. In addition, male patients were more likely to have eosinophil levels higher than 3% than female patients.Conclusion: Gender plays a role in the development and outcome of asthma exacerbations at different ages of pediatrics. A better understanding of gender-based and age-based differences in asthma dictates a personalized approach to treatment.

General Engineering

Education

In this special issue of the Australasian Journal of Educational Technology, we take a step back from the events of the last 2 years and the changes that we have seen in the education arena, to remember that which has remained constant – how students learn best. Developing teaching and learning pedagogy based on lasting education theory and practice makes the past of education relevant to the present and future and creates a context where innovation can be scaled and taken further, from a single instance of impact to many. In this editorial, we present an argument for going back to our roots and present examples of the effective use of established theories of learning that continue to advance online education practice. We discuss the scaling of educational best practice to more students and more institutions, and we provide recommendations for creating sustainable and lasting future practice.

Neurology (clinical)

ImportancePatients with dementia may be at an increased suicide risk. Identifying groups at greatest risk of suicide would support targeted risk reduction efforts by clinical dementia services.ObjectivesTo examine the association between a dementia diagnosis and suicide risk in the general population and to identify high-risk subgroups.Design, Setting, and ParticipantsThis was a population-based case-control study in England conducted from January 1, 2001, through December 31, 2019. Data were obtained from multiple linked electronic records from primary care, secondary care, and the Office for National Statistics. Included participants were all patients 15 years or older and registered in the Office for National Statistics in England with a death coded as suicide or open verdict from 2001 to 2019. Up to 40 live control participants per suicide case were randomly matched on primary care practice and suicide date.ExposuresPatients with codes referring to a dementia diagnosis were identified in primary care and secondary care databases.Main Outcomes and MeasuresOdds ratios (ORs) were estimated using conditional logistic regression and adjusted for sex and age at suicide/index date.ResultsFrom the total sample of 594 674 patients, 580 159 (97.6%) were controls (median [IQR] age at death, 81.6[72.0-88.4] years; 289 769 male patients [50.0%]), and 14 515 (2.4%) died by suicide (median [IQR] age at death, 47.4 [36.0-59.7] years; 10 850 male patients [74.8%]). Among those who died by suicide, 95 patients (1.9%) had a recorded dementia diagnosis (median [IQR] age at death, 79.5 [67.1-85.5] years; median [IQR] duration of follow-up, 2.3 [1.0-4.4] years). There was no overall significant association between a dementia diagnosis and suicide risk (adjusted OR, 1.05; 95% CI, 0.85-1.29). However, suicide risk was significantly increased in patients diagnosed with dementia before age 65 years (adjusted OR, 2.82; 95% CI, 1.84-4.33), in the first 3 months after diagnosis (adjusted OR, 2.47; 95% CI, 1.49-4.09), and in patients with dementia and psychiatric comorbidity (adjusted OR, 1.52; 95% CI, 1.21-1.93). In patients younger than 65 years and within 3 months of diagnosis, suicide risk was 6.69 times (95% CI, 1.49-30.12) higher than in patients without dementia.Conclusions and RelevanceDiagnostic and management services for dementia, in both primary and secondary care settings, should target suicide risk assessment to the identified high-risk groups.

Surfaces, Coatings and Films, General Physics and Astronomy, Condensed Matter Physics, Surfaces and Interfaces, and General Chemistry

Jurassic Gas Field Development Group (GFDJ) of Kuwait Oil Company (KOC) completed the first ever CO2 foamed acid frac pilot campaign in three Jurassic sour HTHP wells. This innovative technology was utilized first time ever in the KOC history safely and effectively with exemplary well performances. GFDJ had been pursuing the CO2-foamed acid fracturing technology since 2019 with the objective of improving the stimulation and hydraulic fracturing efficiency in the Jurassic Middle Marrat formation. CO2-foamed acid fracs have several advantages over other stimulation techniques:CO2 is a miscible and non-damaging fluid blends in water and also mixes with hydrocarbons.Pumped as a liquid and slightly heavier than water, leading to lower treating pressures due to heavier hydrostatic head.Effective in treating lower-pressured/partially-depleted good KH carbonate reservoirs.Reduces water-based gels and overall frac-load volume by the percentage of CO2 pumped in the frac fluid system (40% by volume is utilized in this pilot).Energizes the frac fluid and stays in solution until it heats up to gas. This property ensures the frac load recovery is achieved throughout the flowback.Eliminates the need to activate the well after the frac with CT/N2 applications potentially saving time and money to KOC.Has potential to lighten up the heavier ends of the hydrocarbons due to its miscible properties, hence may help with better hydrocarbon inflow.Creates stable foam structure with the frac fluid, increasing the frac fluid viscosity hence has the potential to generate better frac geometry and higher "stimulated rock volume" or SRV. A three-well campaign was completed between September 2021 and February 2022. Three different monobore completion wells were fracture-treated using an average of 40% downhole quality CO2-foam pumped at an average rate of 30 bpm. Different service companies and their fluid systems, as well as their operational capabilities were utilized in operations with exemplary clean up and production test results that surpassed the expectations of the asset. Additionally, pumping cryogenic CO2 at high ambient desert temperatures of September in Kuwait, safely, and operationally effectively is a major milestone and achievement in itself. This paper summarizes the design, operational, well clean-up and production performance details of the CO2 campaign. Learnings of the GFDJ asset will be shared in order to benefit from the learning curve that KOC went through in implementing this strategic application. Success of novel CO2 stimulation technique is critical for the GFDJ asset to continue expanding its production capacity in next 2-3 years while maintaining the strong production plateau achieved in 2021. Future plans of the assets will also be discussed to ensure cross-boundary opportunity realization can be possible in the industry for the region.

This paper demonstrates the production optimization methodology being used by Kuwait Oil Company Jurassic gas that added significant contribution of approximately 37% of total field incremental production gain in 2021. Production optimization is a continuous iterative process to improve production, especially in mature fields. The North Kuwait Jurassic Gas field’s team has adopted an integrated enhanced and structured process to identify opportunities for production optimization with a pro-active approach focusing on flowing wells and rig-less interventions to tackle production challenges and achieve production targets. The Jurassic gas asset has unique mature-field challenges. It produces mainly from deep (up to 19,000 ft MD) high pressure and temperature, conventional and unconventional tight carbonate reservoirs, highly deviated to horizontal wells, different completion configurations (4.5in monobore, 3.5in × 5in liner, and 4.5in Multi-stages completions), wellbore cleaning and accessibility, scaling and flow assurance, high heterogeneity and permeability contrast among different flow units and dual permeability effect (matrix and natural fractures), production decline due to pressure depletion, liquid loading, high H2S (up to 13 mol%), surface production facilities limitations (e.g. limited MP and H2S handling capacity). effectiveness of subsequent stimulation treatments of such complex heterogeneous reservoir to improve well productivity and connect the natural fractures. The recovery from such complex heterogeneous reservoirs is extremely challenging if conventional development strategies are applied and need for appropriate production optimization methodology outlined here. The Heterogeneity Index process is utilized to rapidly demonstrate production gain opportunities via quick screening method of identifying preliminary candidate wells with anomalous behavior (over/under performance) for further analysis. The results from this screening tool were utilized to identify the families of type productivity problems at field and well levels with solution categories for production enhancement. Representative wells were selected for detailed diagnostics based on the relevance and size of productivity impact and the potential of its well deliverability. Once a few "top potential" wells were identified, production engineering workflows were implemented to assess and forecast the potential of production increase and to determine and evaluate the best solution design and intervention action. Detailed production optimization process provided recommendations of various remedial intervention solutions to improve well production potential via productivity enhancement ranging from complex matrix and fracturing stimulation, additional and/or re-perforations, wellbore cleaning, flow assurance solutions, to choke management. Other advanced technologies were applied to improve various strategies, including completions, perforation, stimulation, and production control. The executions of recommended interventions added significant contribution of approximately 37% of total field incremental production gain in 2021. Such production optimization process, experience and lessons learned will be shared where it can be used in analog fields.

Purpose: To investigates if there is an association between demographic characteristics with sleep quality and general health. Also, to measure the association between lack of sleep and mental health, and to determine the relationship between sleep problems and social health. Methods: A quantitative cross-sectional analytical study was conducted among 270 students at Imam Abdulrahman bin Faisal University in Dammam. Data was collected by using primary data collection method through an online questionnaire. The questionnaire included demographic characteristics, Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality and General Health Questionnaire – 28 (GHQ-28) to assess general health. Chi-square was used to find the relationship between sleep quality, general health, and demographic characteristics, then logistic regression was used to observe the association between sleep quality and general health. Results: About 51.5% of students had poor sleep quality, 47.8% had poor general health, and a total of 48.82% of students had both poor sleep quality and general health. Demographic factors among males showed a significant association with sleep quality and general health. Female participants had a higher percentage of poor sleep quality and poor general health compared to male counterparts. Also, sleep quality showed a significant association with mental and social health. Finally, poor sleep increases the chance of having poor health by 2.7 times (95% CI: 1.672 - 4.486). Conclusion: This study has demonstrated that the quality of sleep significantly affects the quality of health among college students. Also, sleep quality was observed to have a stronger effect on mental health than social health.

Social Media Marketing, Brand Equity, Entrepreneurship, Buying Intentions, Jordanian Context

The current research aims to provide a comprehensive insight into the effect of social media marketing on customer buying intention. Furthermore, the study explores empirically and explains the mediating influences of brand equity, particularly the role of brand image and awareness, on customer buying intention. The research was explored using a quantitative approach. A convenience sampling technique was adopted. The valid responses received were 237. The hypothesis testing followed Structural Equation Modelling. The findings concede that all social media marketing sub-constructs significantly affect buying intention, whereby accessibility has the strongest influence. Brand equity mediates the relationship between social media marketing and purchase intention. The findings concede that all social media marketing sub-constructs significantly affect buying intention, mediated by brand equity, particularly by building brand image and brand awareness. The proposed model provides new insights into the social media marketing drivers affecting buying intentions and engagement with an entrepreneurial brand. This research reaffirms that social media marketing can hugely influence the success of Jordanian entrepreneurial firms.

General Engineering

Computer Science Applications and Education

Cardiology and Cardiovascular Medicine

Aims In response to pro-fibrotic signals, scleraxis regulates cardiac fibroblast activation in vitro via transcriptional control of key fibrosis genes such as collagen and fibronectin; however, its role in vivo is unknown. The present study assessed the impact of scleraxis loss on fibroblast activation, cardiac fibrosis, and dysfunction in pressure overload-induced heart failure. Methods and results Scleraxis expression was upregulated in the hearts of non-ischemic dilated cardiomyopathy patients, and in mice subjected to pressure overload by transverse aortic constriction (TAC). Tamoxifen-inducible fibroblast-specific scleraxis knockout (Scx-fKO) completely attenuated cardiac fibrosis, and significantly improved cardiac systolic function and ventricular remodelling, following TAC compared to Scx+/+ TAC mice, concomitant with attenuation of fibroblast activation. Scleraxis deletion, after the establishment of cardiac fibrosis, attenuated the further functional decline observed in Scx+/+ mice, with a reduction in cardiac myofibroblasts. Notably, scleraxis knockout reduced pressure overload-induced mortality from 33% to zero, without affecting the degree of cardiac hypertrophy. Scleraxis directly regulated transcription of the myofibroblast marker periostin, and cardiac fibroblasts lacking scleraxis failed to upregulate periostin synthesis and secretion in response to pro-fibrotic transforming growth factor β. Conclusion Scleraxis governs fibroblast activation in pressure overload-induced heart failure, and scleraxis knockout attenuated fibrosis and improved cardiac function and survival. These findings identify scleraxis as a viable target for the development of novel anti-fibrotic treatments.

Psychiatry and Mental health, Geriatrics and Gerontology, Clinical Psychology, General Medicine, and General Neuroscience

Background: Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) differ in their memory, attention, and visuoconstructional characteristics. The subscales of the well-known Mini-Mental State Examination (MMSE) provide an opportunity to assess these characteristics. Previous research has shown that analysis of the MMSE subscale performance of AD and DLB patients helps to differentiate them. Objective: Study the MMSE scores of AD and DLB patients to see if the ability of previously reported analyses to differentiate them could be improved. Include other dementia patients for perspective. Methods: We studied the MMSEs of all patients seen in our clinics during an 18-month period. Different equations were studied, derived from the subscales of Memory (M, 3 points maximum), Attention (A, 5 points maximum), and Pentagon-copying (P, 1 point maximum). Results: We obtained 400 MMSEs, 136 from AD patients and 24 from DLB patients, scoring range 1–30. The equation P minus M provided the best discrimination between AD and DLB. Using a P-M score = 1 to identify AD, the positive predictive value was 0.97, negative predictive value 0.22, specificity 0.92, and sensitivity 0.43. As a secondary finding, the P-M = 1 equation was also helpful to differentiate AD from Parkinson’s disease dementia. Conclusion: Considering AD versus DLB in our clinic population, a demented patient who was unable to recall the three memory words on the MMSE but able to copy the intersecting pentagons had a 97% likelihood of having AD. Additional work is needed to improve the sensitivity of the P-M = 1 equation.

Pharmaceutical Science and Pharmacy

Pedagogy, Blueprint, Hyperloop, Formative assessment, Visual arts, Sketch, Creativity, media_common.quotation_subject, media_common, Jargon, The Internet, business.industry, business, Transformative learning, and Psychology

Late in the summer of 2013, Elon Musk set the Internet ablaze with a “napkin sketch” of the Hyperloop Alpha, his futuristic vision for mass transit (Christensen, 2013). Musk backed his rudimentary doodle with a 57-page memo where he aimed to keep “numbers to a minimum and avoid formulas and jargon” and apologized, “in advance for [his] loose use of the language and imperfect analogies” (Musk, 2013). The memo is a thorough, visually stunning and inspiring proposal for a high-speed mass transit line between Los Angeles and San Francisco wherein passengers travel at speeds up to 800 miles per hour above already existing highways. As The New Yorker magazine noted, “Musk has put forth a plausible idea that doesn’t require yet-to-be-developed technologies” (Friend, 2013). The memo and it’s 25+ visual sketches, drawings, and figures is, however, the blueprint for something much more impressive than a regional transit line. Instead, the memo presents a promising, innovative, and potentially transformative model that may completely redefine mass transit in the twenty-first century (Figs. 7.1 and 7.2).

Surgery

Lipoid proteinosis (LP) is a rare autosomal-recessive disease characterized by the deposition of hyaline material infiltrating multiple body organs, including the larynx. The possible clinical presentations are wide-ranging. Laryngeal involvement results in dysphonia that is noted at birth or infantile years. The diagnosis is based on histological findings, and the management options vary depending on the severity of the symptoms. In this paper, we report an unusual case of LP with laryngeal involvement in an adult patient, along with a review of current literature.

Assessment, Filipino Immunizing Pharmacist, Engagement, COVID-19, KAP Model, and General Medicine

The immunization practice of pharmacists has only been recently approved in the Philippines; thus, it is imperative to assess their engagement using the Knowledge, Attitudes, Practices (KAP) model. A descriptive quantitative-correlational study that utilized a convenience sampling technique was conducted with 90 respondents. A 49-item self-made questionnaire was employed through Google forms. The data collected was subjected to various statistical treatments for descriptive and correlational analysis. Results showed that respondents have a high level of knowledge regarding the prevention of Adverse Events Following Immunization (3.81), and critical thinking and decision-making upon its occurrence (3.92). The respondents' attitudes also showed high levels of agreement toward the promotion of immunization (3.89) and patient counseling (3.97). Moreover, the majority of the respondents administered vaccines (87.78%) and COVID-19 was the vaccine given the most (77.78%). Their responses showed a high level of practice in the immunization process (3.95), documentation and record-keeping (3.80), and addressing misconceptions (3.94). Most of their sociodemographic profiles do not have a significant relationship with their KAP except for the area of practice that had a correlation to knowledge. Thus, this study proves that Filipino immunizing pharmacists have a high level of engagement amidst the pandemic and continuous training and certification are needed to further strengthen this, especially during public health emergencies.

General Medicine, Cell Biology, Developmental Biology, Embryology, and Anatomy

Computer Science Applications and Education

Electronic, Optical and Magnetic Materials

Ophthalmology and General Medicine

Multidisciplinary

Pollution, Waste Management and Disposal, Environmental Chemistry, and Environmental Engineering

General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology, General Medicine, and General Neuroscience

Background The study’s objective was to analyze the influence of an 8-week neuromuscular electrical stimulation (NMES) with a plyometric (PT) and strength training (ST) program on muscular, sprint, and functional performances in collegiate male football players. Methods Sixty collegiate male football players participated in this randomized controlled trial single-blind study. All the participants were randomly divided into two groups: (1) NMES group (Experimental, n = 30) who received NMES assisted ST and (2) sham NMES group (Control, n = 30) who received sham NMES assisted ST. In addition, participants from both groups received a PT program; both groups received intervention on three days a week for 8-weeks. The study’s outcomes, such as muscular, sprint, and functional performances, were assessed using a strength test (STN) for quadriceps muscle, sprint test (ST), and single-leg triple hop test (SLTHT), respectively, at baseline pre-intervention and 8-week post-intervention. The interaction between group and time was identified using a mixed design (2 × 2) ANOVA. Results Significant difference found across the two time points for the scores of STN: F (1.58) = 5,479.70, p < 0.05; SLTHT: F (1.58) = 118.17, p < 0.05; and ST: F (1.58) = 201.63, p < 0.05. Similarly, the significant differences were found between groups averaged across time for the scores of STN: F (1.58) = 759.62, p < 0.05 and ST: F (1.58) = 10.08, p < 0.05. In addition, after 8-week of training, Cohen’s d observed between two groups a large to medium treatment’s effect size for the outcome STN (d = 10.84) and ST (d = 1.31). However, a small effect size was observed only for the SLTHT (d = 0.613). Conclusions Findings suggest that the effect of PT and ST with either NMES or sham NMES are equally capable of enhancing muscular, sprint, and functional performances in collegiate male football players. However, PT and ST with NMES have shown an advantage over PT and ST with sham NMES in improving muscular performance and sprint performance among the same participants.

General Medicine, Cell Biology, Developmental Biology, Embryology, and Anatomy

Background Healthcare workers are at the risk of developing weakness in core muscles and balance disturbance due to stress at the workplace. The purpose of this study was to examine the relationship between core muscle strength measured with a plank test and dynamic balance assessed with the modified Star Excursion Balance Test (MSEBT) among hospital staff. A convenience sample of 27 healthy male employees at Rabigh General Hospital participated in the study; participants performed MSEBT and plank tests in the gym of the physical therapy department at the hospital. Results The mean age of the 27 participants was 32.19, standard deviation (SD) 4.16 years; mean height was 171.15, SD 6.39 cm; mean weight was 72.37, SD 11 kg; and body mass index was 24.73, SD 3.62 kg/m2. Pearson’s correlation coefficient showed a positive significant correlation between scores on the plank test with leg reach scores on MSEBT. The data showed a highest correlation between scores on plank test with dominant anterior leg reach scores on MSEBT (r = 0.446, p = 0.010), and lowest with non-dominant anterior leg reach scores on MSEBT (r = 0.335, p = 0.044). Conclusion Weak to moderate positive significant correlation between the plank test of isometric core muscle strength and both the right and dominant of the anterior, posteromedial, and composite score on the MSEBT of the lower limb and significantly with non-dominant anterior reach. There was no significant difference between the administrative and health practitioner on the plank test or MSEBT.

Education

BackgroundGlobally, there is a rising interest in the concept of social accountability (SA). The literature evaluating SA of medical schools is limited; however, some international studies have revealed a lack of understanding of SA by medical students. This study evaluated the perception of SA among medical students at a governmental university in Saudi Arabia.MethodA cross-sectional study with 336 currently enrolled medical students was conducted from September 2020 to May 2021. The data were collected using an electronic survey comprised of the THEnet questionnaire that included 12 items to assess the perception of SA and some demographic variables. The total score was categorized into four groups and compared with the demographic profile of students.ResultsOut of the 336 participants, the mean age was 21.26 ± 0.5 years, with most students in the 19–21 age group (n = 154, 46%), and 189 (56.3%) were males. In addition, preclinical and clinical students had similar representation: 170 (51%) and 166 (49%), respectively. Most participants (173, 52%) scored in the 18–36 range, reflecting good perceived SA. The demographic profile of students (i.e., age, GPA, and year of study) was significantly associated with perceived SA (p = 0.003, 0.002, and < 0.001, respectively).ConclusionThe study concludes that most medical students had a good level of perceived SA about their institution. The preclinical year students exhibited a better perception of SA. The final-year students were more critical about the SA of the institution compared to other students.

General Medicine

La valorisation des déchets recyclables dans les matériaux cimentaires favorise l’écoconstruction. Elle permet d’éviter l’épuisement des ressources naturelles tout en donnant une nouvelle vie aux déchets recyclables qui se trouvent en grande quantité tel que le polyuréthane (PU). Ce travail étudie la faisabilité d’incorporation du PU sous forme de granulé (PUG) dans un mortier cimentaire. Les propriétés du mortier de PUG à l’état frais (teneur en air occlus, masse volumique, affaissement) et à l’état durci (résistance à la flexion et à la compression) sont comparées à un mortier normalisé. Les résultats obtenus montrent la nécessité d’utilisation de 1,5% en masse du ciment de superplastifiant pour une meilleure ouvrabilité du mortier incorporant 5% en masse de PUG. Pour ce taux d’incorporation, une diminution de 6% de la masse volumique à l’état frais, de 42% de la résistance à la compression et de 30% de la résistance à la flexion a été obtenue en raison notamment de la légèreté et de la fragilité du PUG comparé au sable.
Academic Journal of Civil Engineering, Vol 40 No 1 (2022): Special Issue - RUGC 2022

General Medicine

ObjectiveSubsequent protection from SARS-CoV-2 infection in paediatrics is not well reported in the literature. We aimed to describe the clinical characteristics and dynamics of SARS-CoV-2 PCR repositivity in children.DesignThis is a population-level retrospective cohort study.SettingPatients were identified through multiple national-level electronic COVID-19 databases that cover all primary, secondary and tertiary centres in Kuwait.ParticipantsThe study included children 12 years and younger between 28 February 2020 and 6 March 2021. SARS-CoV-2 reinfection was defined as having two or more positive SARS-CoV-2 PCR tests done on a respiratory sample, at least 45 days apart. Clinical data were obtained from the Pediatric COVID-19 Registry in Kuwait.Primary and secondary outcome measuresThe primary measure is to estimate SARS-CoV-2 PCR repositivity rate. The secondary objective was to establish average duration between first and subsequent SARS-CoV-2 infection. Descriptive statistics were used to present clinical data for each infection episode. Also, incidence-sensitivity analysis was performed to evaluate 60-day and 90-day PCR repositivity intervals.ResultsThirty paediatric patients with COVID-19 had SARS-CoV-2 reinfection at an incidence of 1.02 (95% CI 0.71 to 1.45) infection per 100 000 person-days and a median time to reinfection of 83 (IQR 62–128.75) days. The incidence of reinfection decreased to 0.78 (95% CI 0.52 to 1.17) and 0.47 (95% CI 0.28 to 0.79) per person-day when the minimum interval between PCR repositivity was increased to 60 and 90 days, respectively. The mean age of reinfected subjects was 8.5 (IQR 3.7–10.3) years and the majority (70%) were girls. Most children (55.2%) had asymptomatic reinfection. Fever was the most common presentation in symptomatic patients. One immunocompromised experienced two reinfection episodes.ConclusionSARS-CoV-2 reinfection is uncommon in children. Previous confirmed COVID-19 in children seems to result in a milder reinfection.

Endocrinology, Diabetes and Metabolism and Internal Medicine

Background: Factors considered when selecting a diabetes medication for patients with type 2 diabetes (T2D) in clinical practice may differ from those recommended by professional societies. Objective: To identify factors that play a major role in guiding the selection of diabetes medications in the real world. Method: We asked 135 physicians [67% Generalists (Internists and General Practitioners) and 33% Specialists (Endocrinologists and Diabetologists) ] in Saudi Arabia to select a diabetes medication they frequently prescribe in certain clinical scenarios. Then we asked them to rank a set of factors as (“Major,” “Minor,” or “Not” a consideration) according to the degree those factors would typically influence their selection of a particular medication. Results: Sulfonylurea is the most frequently prescribed second-line agent. Majority (89%) reported prescribing GLP-1 receptor agonists (GLP-1 RA) to “50% of their patients with T2D and ischemic heart disease; and over 2/3 prescribe SGLT-2 inhibitors (SGLT-2i) to Conclusion: Despite the recent advances in diabetes therapy, medication cost and inadequate awareness of the cardiovascular and renal benefits of novel diabetes agents, particularly among non-specialists, remain major barriers to the wide adoption of recommendations from professional societies. Policies to improve access to novel diabetes medications and disseminate the awareness about the evidence-based benefits of these medications are needed Disclosure J.A.Abudahesh: None. J.A.Aijebreen: None. D.Z.Alhalees: None. G.Albraithen: None. G.S.Bamogaddam: None. M.Al-sofiani: None.

Otorhinolaryngology

Public Health, Environmental and Occupational Health

Background Public acceptance of governmental measures are key to controlling the spread of infectious diseases. The COVID-19 pandemic has placed a significant burden on healthcare systems for high-income countries as well as low- and middle-income countries (LMICs). The ability of LMICs to respond to the challenge of the COVID-19 pandemic has been limited and may have affected the impact of governmental strategies to control the spread of COVID-19. This study aimed to evaluate and compare public opinion on the governmental COVID-19 response of high and LMICs in the Middle East and benchmark it to international countries. Methods An online, self-administered questionnaire was distributed among different Middle Eastern Arab countries. Participants’ demographics and level of satisfaction with governmental responses to COVID-19 were analyzed and reported. Scores were benchmarked against 19 international values. Results A total of 7395 responses were included. Bahrain scored highest for satisfaction with the governmental response with 38.29 ± 2.93 on a scale of 40, followed by the Kingdom of Saudi Arabia (37.13 ± 3.27), United Arab Emirates (36.56 ± 3.44), Kuwait (35.74 ± 4.85), Jordan (23.08 ± 6.41), and Lebanon (15.39 ± 5.28). Participants’ country of residence was a significant predictor of the satisfaction score (P < 0.001), and participants who suffered income reduction due to the pandemic, had a history of SARS-CoV-2 infection, and held higher educational degrees had significantly lower satisfaction scores (P < 0.001). When benchmarked with other international publics, countries from the Gulf Cooperation Council had the highest satisfaction level, Jordan had an average score, and Lebanon had one of the lowest satisfaction scores. Conclusion The political crisis in Lebanon merged with the existing corruption were associated with the lowest public satisfaction score whereas the economical instability of Jordan placed the country just before the lowest position. On the other hand, the solid economy plus good planning and public trust in the government placed the other countries of the Gulf Cooperation Council on top of the scale. Further investigation is necessary to find out how the governments of other low-income countries may have handled the situation wisely and gained the trust of their publics. This may help convey a clearer picture to Arab governments that have suffered during the pandemic.

Cardiology and Cardiovascular Medicine

Vascular dysfunction underlies numerous significant diseases including diabetes, atherosclerosis and hypertension. Vascular dysfunction can be a result of altered smooth muscle contraction/relaxation, and impaired endothelial cell function within the vessel wall. Vascular fibrosis involves an increase in the thickness of vessel wall. This contributes to either an increase in extracellular matrix (ECM) synthesis or induced vascular smooth muscle proliferation within the vessel wall, or both, causing stiffer vessels with impaired tone and reduced lumen diameter.Our lab identified the transcription factor scleraxis as a novel master regulator of fibrotic signaling in the myocardium, showing scleraxis is sufficient to induce fibroblast to myofibroblast phenotype conversion, a critical step in the development of fibrosis, and directly up-regulates ECM genes in cardiac fibroblasts. Angiotensin II (AngII) was reported to induce vascular fibrosis via activation of the transcription factor Smad3 in aortic vascular smooth muscle cells. Our lab has shown that Smad3 physically interacts with scleraxis, and critically requires scleraxis to drive TGFβ/Smad fibrotic signaling in cardiac fibroblasts.Our preliminary data has revealed that scleraxis is detectable in the arterial wall, and scleraxis expression is elevated in high pressure versus low pressure regions of vessels. Loss of scleraxis in the aortas of scleraxis knock-out mice reveals a discontinuation and disarrangement in the structure of vascular wall. We thus hypothesize that scleraxis is sufficient and necessary to induce vascular fibrosis.Pressure myography data reveals an increase in vascular stiffness and thickness of 3rd order mesenteric arteries of smooth muscle-specific scleraxis overexpression mice. Also, our data shows that vascular stiffness is significantly increased in AngII-induced scleraxis overexpression mice with a relative increase in telemetry blood pressure measurements and pulse wave velocity. Histological sections suggest a reduction of the translamellar ECM accumulations in AngII-induced scleraxis overexpression aortas. To summarize, scleraxis may contribute to vascular stiffness by inducing vascular smooth muscle proliferation.

Infectious Diseases and Microbiology

Biological Psychiatry and Psychiatry and Mental health

social identity, visibility, self-esteem, religiosity, Muslims, prosocial behaviour, adjustment, youth, discrimination, and anti-social behaviour

Previous research has often found religiosity in youth to be largely adaptive, predicting higher prosocial and lower problem behaviours, higher self-regulation, and higher self-esteem, among other outcomes (French et al., 2008). However, most of this research has been done with youth who were members of the majority faith (e.g., Christians in America, Muslims in Indonesia). Key social-psychological theories suggest that the experience of religiosity and an individual’s subsequent outcomes likely differ as a function of their minority status (Hogg & Reid, 2006; Tajfel et al., 1979). This thesis examines the role of religiosity in Muslim minority youth in Canada. Findings demonstrate that religiosity is still generally protective for religious minority youth, however, these relations are highly dependent upon the strength of an individual’s religious identification, the degree to which they believe they are identifiable as a Muslim, the influence of social norms, and their experiences with discrimination. SSRHC CGS-M, Dean's graduate research fund (UofGuelph)

Genetics, Molecular Biology, Biochemistry, and Biotechnology

Neurology (clinical) and Ophthalmology

General Medicine, cardiac fibrosis, energy metabolism, fibroblast, myofibroblast, glutaminolysis, transcription, and gene regulation

Fibrosis is an energy-intensive process requiring the activation of fibroblasts to myofibroblasts, resulting in the increased synthesis of extracellular matrix proteins. Little is known about the transcriptional control of energy metabolism in cardiac fibroblast activation, but glutaminolysis has been implicated in liver and lung fibrosis. Here we explored how pro-fibrotic TGFβ and its effector scleraxis, which drive cardiac fibroblast activation, regulate genes involved in glutaminolysis, particularly the rate-limiting enzyme glutaminase (GLS1). The GLS1 inhibitor CB-839 attenuated TGFβ-induced fibroblast activation. Cardiac fibroblast activation to myofibroblasts by scleraxis overexpression increased glutaminolysis gene expression, including GLS1, while cardiac fibroblasts from scleraxis-null mice showed reduced expression. TGFβ induced GLS1 expression and increased intracellular glutamine and glutamate levels, indicative of increased glutaminolysis, but in scleraxis knockout cells, these measures were attenuated, and the response to TGFβ was lost. The knockdown of scleraxis in activated cardiac fibroblasts reduced GLS1 expression by 75%. Scleraxis transactivated the human GLS1 promoter in luciferase reporter assays, and this effect was dependent on a key scleraxis-binding E-box motif. These results implicate scleraxis-mediated GLS1 expression as a key regulator of glutaminolysis in cardiac fibroblast activation, and blocking scleraxis in this process may provide a means of starving fibroblasts of the energy required for fibrosis.

General Veterinary and Animal Science and Zoology

Citizen science offers an excellent opportunity to engage the public in scientific data collection, educational opportunities, and applied management. However, the practicalities of developing and implementing citizen science programming are often more complex than considered. Some challenges to effective citizen science include scientists’ skepticism about the ability of public participants to rigorously collect quality data; a lack of clarity on or confidence in the utility of data; scientists’ hesitancy in engaging the public in projects; limited financial commitments; and challenges associated with the temporal and geographic scales of projects. To address these challenges, and provide a foundation upon which practitioners, scientists, and the public can credibly engage in citizen science, the Government of Alberta developed a set of citizen science principles. These principles offer a framework for planning, designing, implementing, and evaluating citizen science projects that extend beyond Alberta. Here, we present a case study using these principles to evaluate GrizzTracker, a citizen science program developed to help inform provincial species-at-risk recovery efforts. While we found that GrizzTracker applied each of the six principles in some way, including successful public engagement, strengthened relationships, and raising public awareness about northwest Alberta’s grizzly bears, we also identified a number of challenges. These included ongoing skepticism from the traditional scientific community about the utility of citizen science and governance challenges related to program leadership, staff capacity, and funding. By using the principles as a guideline, we provide policy recommendations for future citizen science efforts, including considerations for program design, implementation, and evaluation.

Vascular Health and Risk Management, Pharmacology (medical), Cardiology and Cardiovascular Medicine, Public Health, Environmental and Occupational Health, Hematology, General Medicine, and Endocrinology, Diabetes and Metabolism

Ali Alhashim, Kawther Hadhiah, Hassan Al-Dandan, Mugbil Aljaman, Majed Alabdali, Mohammed Alshurem, Danah Aljaafari, Mustafa AlQarni Neurology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, 34212, Saudi ArabiaCorrespondence: Ali Alhashim, Neurology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, 34212, Saudi Arabia, Tel +966509444833, Email ahalhashem@iau.edu.saBackground: Spontaneous simultaneous bilateral basal ganglia hemorrhage (SSBBGH) is an extremely rare condition with only a few published case reports and series. However, there is no systematic review that has been published yet.Objective: The study aims to conduct a systematic review on spontaneous simultaneous bilateral basal ganglion bleeding and a descriptive statistical analysis of collected data on epidemiology, clinical features, etiology, therapeutic approach and prognosis. This review aims to be a clinical reference for busy clinicians when they are faced with such a rare condition.Methodology: This review has been carried out in accordance with recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines.Results: Review of 60 cases showed that SSBBGH affected predominantly male patients (70%) with an average age of 50.8 ± 15.33 years and the male-to-female ratio was 2.5:1. The female patients tend to be older with an average age of 54.22 ± 16.67 years. Location of SSBBGHwas more common in the putamen (90% vs 10% non-putaminal). SSBBGH posed a significant mortality rate (33.33%). Among patients who survived, only 40.6% (13/32 report) have had favorable outcomes (mRS ⤠2) and the remaining 59.4% (19/32) ended up with poor functional status (mRS ⥠3-5). The most common implicated etiologies were hypertension followed by alcohol intoxication.Conclusion: SSBBGH is a rare clinical entity with significant morbidity and mortality. Systemic approach can lead to early recognition of etiology and prompt treatment. Hypertension and the putamen are the most common etiology and location of SSBBGH, respectively. History of hypertension and age can help narrow differential diagnosis and limit unnecessary testing or intervention.Keywords: bilateral basal ganglia bleeding, bilateral basal ganglia hemorrhage, non-traumatic, simultaneous

Computer Science Applications and Education

Neurology (clinical) and Neurology

Objective To examine the relative risk of suicide mortality in patients with Huntington’s disease (HD). Methods A case–control study design was used. We used linked electronic records from primary care, secondary care and Office for National Statistics from England from 2001 through 2019. Controls were matched to cases by general practice and suicide date. Odds ratios (ORs) were adjusted for gender and age at suicide/index date. Results Data were available for 594,674 individuals. Patients with HD who died from suicide were significantly younger at time of death than patients with HD who died from causes other than suicide (p Conclusion The markedly elevated suicide risk in patients with HD suggests that implementation of suicide risk assessment may improve survival in individuals with these diseases, especially in younger patients.

General Medicine

Aristotelesarchiv, Mikrofilm, Lizenzierung, FAIR-Prinzipien, Sammlung, Annotieren, Kontextsetzung, Archivierung, Bilder, Infrastruktur, and DHd2022

Der Vortrag rückt die neuen Forschungspraktiken und -möglichkeiten, die sich mit der Digitalisierung jenes Bereichs des kulturellen Gedächtnisses, den das Berliner Aristotelesarchiv bewahrt, in den Fokus. Dabei soll sich zeigen, dass auch ein Rückgriff auf ein nicht mehr zeitgemäß scheinendes Medium wie den Mikrofilm Optionen bereithält, digitale Verfahren anzuschließen. Als Grundlage und Umsetzung digitaler Forschung an Archivalien werden infrastrukturelle Komponenten, die Zugriff und Durchsuchbarkeit gewährleisten, mit forschungsnahen Werkzeugen verzahnt, die wissenschaftlichen und technischen Austausch sowie Nachnutzbarkeit der entstehenden FAIRen Forschungsdaten ermöglichen. Der Vortrag gibt Einblicke, wie man ein weltweit bedeutendes Archiv zukunftsgerichtet für digital gestützte Forschungen aufstellen und damit eine auch digital herausragende Forschungslandschaft konstituieren kann. Ein Beitrag zur 8. Tagung des Verbands "Digital Humanities im deutschsprachigen Raum" - DHd 2022 Kulturen des digitalen Gedächtnisses.

Aristotelesarchiv, Mikrofilm, Lizenzierung, FAIR-Prinzipien, Sammlung, Annotieren, Kontextsetzung, Archivierung, Bilder, Infrastruktur, and DHd2022

Der Vortrag r��ckt die neuen Forschungspraktiken und -m��glichkeiten, die sich mit der Digitalisierung jenes Bereichs des kulturellen Ged��chtnisses, den das Berliner Aristotelesarchiv bewahrt, in den Fokus. Dabei soll sich zeigen, dass auch ein R��ckgriff auf ein nicht mehr zeitgem���� scheinendes Medium wie den Mikrofilm Optionen bereith��lt, digitale Verfahren anzuschlie��en. Als Grundlage und Umsetzung digitaler Forschung an Archivalien werden infrastrukturelle Komponenten, die Zugriff und Durchsuchbarkeit gew��hrleisten, mit forschungsnahen Werkzeugen verzahnt, die wissenschaftlichen und technischen Austausch sowie Nachnutzbarkeit der entstehenden FAIRen Forschungsdaten erm��glichen. Der Vortrag gibt Einblicke, wie man ein weltweit bedeutendes Archiv zukunftsgerichtet f��r digital gest��tzte Forschungen aufstellen und damit eine auch digital herausragende Forschungslandschaft konstituieren kann. Ein Beitrag zur 8. Tagung des Verbands "Digital Humanities im deutschsprachigen Raum" - DHd 2022 Kulturen des digitalen Ged��chtnisses.

Education

In response to the special issue on democratizing creative educational experiences (CEE), we conducted a thematic analysis of recent scholarship on creativity and decolonization (2010–2021) and analyzed recurring tensions across literature grounded in Indigenous, Black, feminist, and non-western epistemological perspectives on creativity. We found themes that are not new but are yet to be taken up consistently and credibly in western creativity and education research and practice. For instance, spirituality emerges as a valuable ingredient for creativity, body as inseparable from the mind, dialectic resistance and resilience as acts of creative existence, and non-human agency as essential to the creative process. Informed by these themes, we share implications for research and practice, seeking new spaces inclusive of historically ignored onto-epistemologies.

General Medicine

Political Science and International Relations, Sociology and Political Science, Cultural Studies, ComputingMilieux_COMPUTERSANDEDUCATION, arts and design, college students, creativity, meditation, and mindfulness

Given the applied nature of creativity in the arts and design, it is important to understand the conditions and practices that support it. Most research suggests that ideal conditions for creativity are often mental and emotional – involving relaxed, yet alert and focused, states of mind. This article explores the connection between mindfulness and creativity in the experiences of students in a college of arts and design, through a mindfulness teaching practice to support creative processes. In a “scholarship of teaching and learning” inquiry, we consider how mindfulness practice may affect arts and design learners’ feelings about their own creativity. Students in a large United States university school of arts and design practiced mindfulness meditation for several months, and submitted a written reflection on their experience. We qualitatively analyze this to consider how mindfulness supports creative practices in arts and design learners’ education. Our findings involve three key themes, which are: “Processing anxiety and negative feelings”, “Focusing the mind”, and “Managing the ‘Voice of Judgment’”. These thematic findings reflect how arts and design students perceive the effects of mindfulness on their creative process. We offer implications for teaching practices related to mindfulness meditation practice aimed to support learners’ perceptions of their creativity.

International Journal of General Medicine

Hassan Al-shehri,1 Dania T Dahmash,2 Niels Rochow,3,4 Basma Alturki,5 Danah Alrajhi,5 Faisal Alayed,5 Faisal Alhazani,5 Hanan Alsuhibany,5 Abdallah Y Naser6 1Department of Pediatrics, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia; 2ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK; 3Department of Pediatrics, Rostock University Medical Center, Rostock, 18057, Germany; 4Department of Pediatrics, Paracelsus Medical University, Nuremberg, 90471, Germany; 5College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia; 6Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman, 11622, JordanCorrespondence: Abdallah Y Naser, Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman, Jordan, Tel +962 795285555, Email abdallah.naser@iu.edu.joPurpose: To analyze trends of conditions originating in the perinatal period (COPP) in England and Wales between 1999 and 2020.Patients and methods: An ecological study of COPP was conducted using hospital admission data from April 1999 to March 2020 from the Hospital Episode Statistics database in England and the Patient Episode Database for Wales.Results: The overall hospital admission rates increased by 41.6%, from 1913 per 100,000 persons (95% CI: 1905â 1922) in 1999 to 2709 (95% CI: 2700â 2719) in 2020 (trend test p< 0.001). The most common causes for neonatal admissions were disorders related to the length of gestation and fetal growth, respiratory and cardiovascular disorders specific to the perinatal period, and hemorrhagic and hematological disorders of newborns (28.8%, 27.3%, and 15.2%, respectively). Although the admission rates increased for both males and females (by 33.1% and 35.1%, respectively), hospital admission rates for all causes were higher among males compared to females (p< 0.05).Conclusion: COPP-related hospital admissions rate in England and Wales increased significantly over the past 21 years. Notably, the proportion of COPP-related hospital admissions of males was higher than females. Further studies are warranted to explore the role of gender in hospital admissions and health care for COPP.Keywords: admissions, England, hospital, perinatal, United Kingdom, Wales

Medicine (General), R5-920, otorhinolaryngologic diseases, Articles, and General Medicine

Summary: Background: Hearing loss affects over 50% of people in the US across their lifespan and there is a lack of decision modeling frameworks to inform optimal hearing healthcare delivery. Our objective was to develop and validate a microsimulation model of hearing loss across the lifespan in the US. Methods: We collaborated with the Lancet Commission on Hearing Loss to outline model structure, identify input data sources, and calibrate/validate DeciBHAL-US (Decision model of the Burden of Hearing loss Across the Lifespan). We populated the model with literature-based estimates and validated the conceptual model with key informants. We validated key model endpoints to the published literature, including: 1) natural history of sensorineural hearing loss (SNHL), 2) natural history of conductive hearing loss (CHL), and 3) the hearing loss cascade of care. We reported the coefficient of variance root mean square error (CV-RMSE), considering values ≤15% to indicate adequate fit. Findings: For SNHL prevalence, the CV-RMSE for model projected male and female age-specific prevalence compared to sex-adjusted National Health and Nutrition Examination Survey (NHANES) data was 4.9 and 5.7%, respectively. Incorporating literature-based age-related decline in SNHL, we validated mean four-frequency average hearing loss in the better ear (dB) among all persons to longitudinal data (CV-RMSE=11.3%). We validated the age-stratified prevalence of CHL to adjusted NHANES data (CV-RMSE=10.9%). We incorporated age- and severity-stratified time to first hearing aid (HA) use data and HA discontinuation data (adjusted for time-period of use) and validated to NHANES estimates on the prevalence of adult HA use (CV-RMSE=10.3%). Interpretation: Our results indicate adequate model fit to internal and external validation data. Future incorporation of cost and severity-stratified utility data will allow for cost-effectiveness analysis of US hearing healthcare interventions across the lifespan. Further research might expand the modeling framework to international settings. Funding: This study was funded by the National Institute on Deafness and Other Communication Disorders and the National Institute on Aging (3UL1-TR002553–03S3 and F30 DC019846).

General Medicine

Psychiatry and Mental health, Clinical Psychology, Ethnic group, Population based study, Incidence (epidemiology), Confidence interval, Suicide Risk, Odds ratio, Asian ethnicity, Medicine, business.industry, business, Demography, Public health, and medicine.medical_specialty

Using multiple linked electronic health databases, we conducted a large case-control study in England from 2001 through 2019 to examine the association between ethnicity and suicide risk. Asian, Black and Other ethnic groups had a significantly lower suicide risk compared to White individuals, with those of Asian ethnicity having the lowest risk (Odds Ratio 0.53, 95% Confidence Interval 0.47-0.60). This ethnicity related suicide risk was significantly altered by socio-demographic characteristics. These factors can inform the assessment and stratification of suicide risk, as well as the targeting of public health measures designed to reduce suicide incidence.

Thoracolumbar fractures are common axial skeleton fractures. Mainly affecting T10-L2, considered TL junction. Management is according to the fracture type and spinal stability. Open traditional approach carries more complication as compared with minimally invasive percutaneous fixation, but it is considered having same long term outcome. We have evaluated our local data if the minimally invasive technique is superior than the open one in terms of short-term outcome. It has been seen that MIS for TLF is superior in terms of early recovery and return to work, when compared the open technique retrospectively

epiregulin, leptin receptor, ERK, EGFR, glucose uptake, energy metabolism, General Medicine, Biology (General), QH301-705.5, and hormones, hormone substitutes, and hormone antagonists

The leptin receptor (LepR) acts as a signaling nexus for the regulation of glucose uptake and obesity, among other metabolic responses. The functional role of LepR under leptin-deficient conditions remains unclear. This study reports that epiregulin (EREG) governed glucose uptake in vitro and in vivo in Lepob mice by activating LepR under leptin-deficient conditions. Single and long-term treatment with EREG effectively rescued glucose intolerance in comparative insulin and EREG tolerance tests in Lepob mice. The immunoprecipitation study revealed binding between EREG and LepR in adipose tissue of Lepob mice. EREG/LepR regulated glucose uptake without changes in obesity in Lepob mice via mechanisms, including ERK activation and translocation of GLUT4 to the cell surface. EREG-dependent glucose uptake was abolished in Leprdb mice which supports a key role of LepR in this process. In contrast, inhibition of the canonical epidermal growth factor receptor (EGFR) pathway implicated in other EREG responses, increased glucose uptake. Our data provide a basis for understanding glycemic responses of EREG that are dependent on LepR unlike functions mediated by EGFR, including leptin secretion, thermogenesis, pain, growth, and other responses. The computational analysis identified a conserved amino acid sequence, supporting an evolutionary role of EREG as an alternative LepR ligand.

Computer Science Applications and Education

Otorhinolaryngology and Surgery

Radiology, Nuclear Medicine and imaging, General Medicine, and eye diseases

Increased intracranial pressure is the most common cause of papilledema. Multiple etiologies such as cerebral edema, hydrocephalus, space occupying lesions, infection, and idiopathic intracranial hypertension among others should be considered. Imaging plays a critical role in the detection of pathologies that can cause papilledema. MRI with contrast and CE-MRV, in particular, are key for the diagnosis of idiopathic intracranial hypertension. This review will focus in common and infrequent causes of papilledema, the role of imaging in patients with papilledema as well as its potential mimickers.

FDA, Piflufolastat-F18, Antibody-drug conjugate, Casimersen, Dasiglucagon, Difelikefalin, Inclisiran, Vosoritide, Drugs, Voclosporin, Loncastuximab tesirine-lpyl, Melphalan flufenamide, odevixibat, Oligonucleotides, Pegcetacoplan, Peptides, Tisotumab vedotin-tftv, 1115 Pharmacology and Pharmaceutical Sciences, Drug Discovery, Pharmaceutical Science, and Molecular Medicine

From the medical, pharmaceutical, and social perspectives, 2021 has been a year dominated by the COVID-19 pandemic. However, despite this global health crisis, the pharmaceutical industry has continued its endeavors, and 2021 could be considered an excellent year in terms of the drugs accepted by the US Food and Drug Administration (FDA). Thus, during this year, the FDA has approved 50 novel drugs, of which 36 are new chemical entities and 14 biologics. It has also authorized 10 TIDES (8 peptides, 2 oligonucleotides), in addition to 2 antibody-drug conjugates (ADCs) whose structures contain peptides. Thus, TIDES have accounted for about 24% of the approvals in the various drug categories. Importantly, this percentage has surpassed the figure in 2020 (10%), thus reflecting the remarkable success of TIDES. In this review, the approved TIDE-based drugs are analyzed on the basis of their chemical structure, medical target, mode of action, administration route, and adverse effects.
The work performed by the authors is funded by the National Research Foundation (NRF) and the University of KwaZulu-Natal.

General Medicine

ddc:004, HMC, Digital Humanities, Annotations, Metadata, Research Data Management, DATA processing & computer science, and Annotation, Digital Humanities, HMC

Annotieren ist eine der ältesten Kulturtechniken der Menschheit. Während in den vergangenen Jahrhunderten Stift und Papier die Mittel der Wahl waren um Anmerkungen zu einer Quelle hinzuzufügen, verschiebt sich diese Aktivität in den letzten Jahren zunehmend in die digitale Welt. Mit der W3C-Empfehlung ‘Web Annotation Data Model’ steht seit 2017 ein mächtiges Werkzeug zur Verfügung, um Annotationen in verschiedensten Disziplinen zu modellieren und eine disziplin- sowie plattformübergreifende Auswertung zu ermöglichen. In diesem Poster möchten wir einen Einblick in unsere Annotationsinfrastruktur geben, die in drei geisteswissenschaftlichen Forschungsprojekten im Einsatz ist. Dabei stehen sowohl ein eigens entwickelter Annotationsserver mit RDF-Backend (vollständig kompatibel zum ‘Web Annotation Protocol’) als auch unsere Annotationsoberflächen im Fokus. Es sollen das Zusammenspiel dieser Komponenten untereinander aber auch mit weiteren Infrastrukturkomponenten, wie beispielsweise einem Forschungsdatenrepositorium oder einem Vokabulareditor, sowie die tägliche Arbeit der Forschenden mit diesen Komponenten illustriert werden. Besonderesr Augenmerk soll auf die Modellierung der Annotationen in unseren unterschiedlichen Anwendungsfällen gelegt werden. Die Beispiele reichen dabei von Auszeichnungen logischer Diagramme in mittelalterlichen Aristoteles-Handschriften, über die Analyse von Metaphern im Prozessin religiöser Sinnbildung bis hin zur Erfassung besonderer hebräischern Buchstabenvariationen in Torarollen. Die Diskussion von Gemeinsamkeiten und Unterschieden in diesen Anwendungsfällen birgt dabei ein großes Potential für die Übertragbarkeit und Fruchtbarmachung in weiteren wissenschaftlichen Disziplinen.

Urology and General Medicine

Education

In recent years, there has been a shift towards seeing employability as a key outcome of higher education (HE). Despite this, there is still a concern that graduates are not well prepared for the labour market. One way to bridge the gap between education and the labour market is to involve employers in considerations of employability frameworks or sets of required graduate attributes. This paper reports on a study aimed at identifying how employers of medical graduates in Saudi Arabia conceptualise quality in HE. The main objective of this study is to develop a model of quality in HE that incorporates employers’ views of medical education and its graduates. An exploratory two-stage design was adopted, utilising interviews and survey data. This paper discusses the interview findings relating to medical graduates’ attributes in particular. Fourteen medical employers were interviewed to determine how they conceptualise quality in relation to medical educational experience and graduate attributes. Thematic Analysis of these interviews suggests that views of quality fall into three broad themes: Graduate Abilities, Graduate Readiness, and Research and Engagement Experience. Data drawn from these interviews indicate that employers favour the soft skills of medical graduates over their basic medical knowledge. Additionally, effective practical skills were cited as being of particular importance and highly desirable. This study has implications for the development and delivery of medical education in Saudi Arabia, aspiring to narrow the gap between HE and the labour market.

ddc:004, Metadata, research data management, FAIR Digital Object, and DATA processing & computer science

A sophisticated ensemble of services and tools enables high-level research data and research metadata management in science. On a technical level, research datasets need to be registered, preserved, and made interactively accessible using repositories that meet the specific requirements of scientists in terms of flexibility and performance. These requirements are fulfilled by the Base Repo and the MetaStore of the KIT Data Manager Framework. In our data management architecture, data and metadata are represented as FAIR Digital Objects that are machine actionable. The Typed PID Maker and the FAIR Digital Object Lab provide support for the creation and management of data objects. Other tools enable editing of metadata documents, annotation of data and metadata, building collections of data objects, and creating controlled vocabularies. Information systems such as the Metadata Standards Catalog and the Data Collections Explorer help researchers select domain-specific metadata standards and schemas and identify data collections of interest. Infrastructure developers search the Catalog of Repository Systems for information on modern repository systems, and the FAIR Digital Object Cookbook for recipes for creating FAIR Digital Objects. Existing knowledge about metadata management, services, tools, and information systems has been applied to create research data management architectures for a variety of fields, including digital humanities, materials science, biology, and nanoscience. For Scanning Electron Microscopy, Transmission Electron Microscopy and Magnetic Resonance Imaging, metadata schemas were developed in close cooperation with the domain specialists and incorporated in the research data management architectures. This research has been supported by the research program ‘Engineering Digital Futures’ of the Helmholtz Association of German Research Centers, the Helmholtz Metadata Collaboration (HMC) Platform, the German National Research Data Infrastructure (NFDI), the German Research Foundation (DFG) and the Joint Lab “Integrated Model and Data Driven Materials Characterization (MDMC)”. Also, this project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 101007417 within the framework of the NFFA-Europe Pilot (NEP) Joint Activities.

Artificial Intelligence, Computer Networks and Communications, Computer Science Applications, Communication, Information Systems, and Software

This study aims to provide comprehensive insights into the social media marketing characteristics affecting customer buying intention. The model was theoretically based on and explored using a quantitative approach. A survey strategy was adopted, and a five-point Likert questionnaire was distributed to Jordanian citizens. A total of 237 responses were received. The hypothesis testing followed structural equation modeling using SPSS software. The findings suggest that all social media marketing subcontracts exhibit a significant positive effect on buying intention, whereby accessibility is the highest. Customer involvement also moderates the relationship between social media marketing and customer buying intention. The proposed model provides new insights into social media marketing drivers affecting buying intentions and engagement with an entrepreneurial brand or product. This study reaffirms that social media marketing can significantly influence the success of Jordanian entrepreneurial firms and understanding how to use this tool effectively can significantly change how businesses operate.

Background: The coronavirus 2019 (COVID-19) pandemic has triggered a paradigm shift to a curriculum that relies entirely on virtual learning. This study identified the impact of the COVID-19 pandemic-related precautions on clinical year students' medical education and determined whether the lack of exposure to clinical settings affected their choice of specialty. Methods: A cross-sectional study was carried out in 25 medical schools in all 13 regions of Saudi Arabia between December 2020 and May 2021. An online survey using Google Form platform was used to collect the data. Results: Of the 996 students who responded to the survey, 55.2% were in their final year. The results showed alterations in all aspects of academic settings; almost half of the participants had their written exams (49.1%, n = 475), clinical examinations (objective structured clinical examination; 45.8%, n = 442), and clinical rotations (43%, n = 415) changed. Of the participants, 40.3% (n = 389) stated that the COVID-19 pandemic-related precautions made them reconsider their specialty of interest. The most common reason was a lack of clinical exposure, particularly in terms of engagement with teaching faculty in hospital settings. Conclusion: The findings of this study showed that the lack of preparation, exposure, particularly in terms of engagement with teaching faculty in hospital settings among clinical year medical students affected their confidence, which, in turn, influenced their choice of specialty.

Architectural design, Interior design, Automation and technology in building and construction, Design practice and methods, Industrial and product design, Interaction and experience design, Other education not elsewhere classified, and Acoustics and noise control (excl. architectural acoustics)

This Thesis investigates personal private sound control via headsets (modified soundscape) to mitigate the perceived deficiencies of inadequate environs. This is achieved by exploring the benefit of using soundscape as a key element used by students in such learning environs. It examines the result of conducting a creative task while exposed to different sound conditions. These results were then assessed according to two aspects of assessments: Self-assessment (by participants) and independent judgments (Design Jury) and the results of those assessments were compared. The result of this research showed a significant difference between the self-assessment and the independent judgment in terms of the most effective sound condition which was associated with increased participants’ creativity.

Ozone refers to a tri-atomic oxygen molecule and is present in stratosphere abundantly. Ozone is known to have multiple medical and dental properties. Use of ozone therapy in the field of dentistry dates back to 1930s where wound healing and disinfection were its initial use. Later, owing to its properties its use expanded to treatment of various oral disorders. Ozone treatment has been more effective than conventional therapies that follow a less invasive and conservative approach to dental treatment. The purpose of this research is to review the available information about applications of ozone in dentistry. Ozone treatment has so far been used for wound healing, tooth decay, oral lichen planus, gingivitis, periodontitis, halitosis, osteonecrosis of the jaw, postoperative pain, plaque and biofilms, dentin hypersensitivity, temporomandibular joint disorders, among several others. Ozone has been successfully transformed the oral and dental treatment. Ozone therapy is a very effective treatment with no side effects or pain. It also reduces the patient's anxiety and level of stress as it reduces the duration of treatment. Ozone provides a painless alternative to the common treatment of tooth decay and has been proven to stop root decay, pits and fissure and relieve ulcers clinically. Its anti-microbial action against endodontic flora is quite promising, however more clinical research and trials in future can be beneficial.

Public Health, Environmental and Occupational Health and Community and Home Care

Objective: Many studied investigated the manifestations of COVID-19, yet few described the pattern and severity of otolaryngological symptoms. We aim to describe the picture of COVID-19-associated otorhinolaryngological manifestations and recovery to explore individualized treatment, onward referral, and complications prevention. Design: Prospective longitudinal questionnaire-based study. Setting: The online questionnaire was filled 3 times through a remote interview over a period of 1 month from June 2020 to July 2020. Participants: Patients with confirmed COVID-19 by RT-PCR who were clinically stable. Main Outcome Measures: Date of diagnosis, sociodemographic data, and the presence of predictive factors, such as nasal and paranasal disease, anosmia and dysgeusia. Validated tools were used, such as Sino-nasal Outcome Test (SNOT-22), smell test (medical academy screening tool), Voice Handicap Index (VHI), and Reflux Symptoms Index (RSI). Result: The questionnaire was sent to 363 patients and the response rate was 70.80% (n = 257). The mean age was 34.58 years (SD = 11.22) and the rate of male participants was 60.7%. The most common otorhinolaryngological symptoms at the time of enrollment was fever (48.6%), whilst the commonest severe symptom was cough (57%). After 1 month, only 11 participants had persistent severe symptoms, especially sleep and psychological symptoms (73%), and the majority were female (63.6%). All of them had at least 1 comorbidity. There was a significant difference between the mean age of participants with severe symptoms (mean = 27.45, SD = 8.39) and without severe symptoms (mean = 34.90, SD = 2.53, t(255) = 2.17, P = .031). Conclusion: COVID-19 has a wide-ranged spectrum of presentations, with otorhinolaryngological symptoms being the commonest and most serious. Studying these symptoms is vital to advance management options.

General Medicine

Introduction: The onset of the COVID-19 pandemic resulted in governments implementing new regulations to divert healthcare resources, which in return led to the postponement of elective and semi-elective surgical procedures. Therefore, many surgeons and as well as surgeons in training reported feeling redundant, which eventually resulted in psychological distress. This study aimed to assess the sociodemographic differences in the psychological impact resulting from the COVID-19 pandemic and outline the effect it had on surgical training. Methods: This is a cross-sectional study conducted in Kuwait. Data were collected by distributing a questionnaire electronically to surgeons and surgeons in training. The survey included questions aimed at assessing both the effect of the pandemic on surgical training and the psychological impact it had on surgeons, assessing the latter using the Depression, Anxiety and Stress Scale-21 screening tool. Results: The response rate for the study was 52%, with the majority being junior male surgeons. A majority of surgeons in training reported postponement of their scheduled academic teaching sessions (78.9%) and pre-assigned surgical rotations (65.8%). In terms of the psychological impact of the pandemic, a majority of the participants reported an element of depression and stress, 61.2% and 55%, respectively, while approximately half, 48.1%, had symptoms associated with anxiety. Conclusion: The COVID-19 pandemic had a negative association with the psychological well-being of a significant proportion of surgeons and associated surgical training programs.

General Medicine

Background: Irritable bowel syndrome (IBS) is a chronic gastrointestinal condition presented by abdominal discomfort due to unknown cause. The prevalence of IBS in the world extends between 5.7% to 34%, with different ranges based on the tools used for diagnosis. Evidence has indicated genetic predisposition and psychosocial stress as risk factors. This study aims to assess the prevalence of IBS with its subtypes in undergraduate medical students using Rome III criteria. We also investigated the association of IBS and emotional disorders including stress among undergraduate medical students in Saudi Arabia. Methods: This cross-sectional study was conducted in January and February 2021 among undergraduate medical students in Saudi Arabia. Volunteer participants answered the questions relating to demographics and surveys containing the Rome III criteria and the Self-reported Stress questionnaire. Results: A total of 300 participants were recruited of whom 63.7% were females. The majority of the participants were aged more than 22 years (72.7%). IBS prevalence in undergraduate medical students was 49.3% in Saudi Arabia which was higher than the global prevalence of IBS. There are many associated factors with IBS including female gender, higher academic year, sleeping less than 6 hours and less exercise practicing. Conclusion: Higher prevalence of IBS was detected in undergraduate medical students in Saudi Arabia than worldwide prevalence. Female gender, higher academic grades, less exercise practicing and sleep disturbance were predictors for IBS. More screening and management of stress causes are needed to decrease medical field stressors. Key words: Irritable bowel syndrome, medical students, stress, sedentary lifestyle

Social Sciences (miscellaneous) and Anthropology

With the emergence of Western posthuman understandings, new materialism, artificial intelligence (AI), and the growing acknowledgment of Indigenous epistemologies, an ongoing rethinking of existing assumptions and meanings about creativity is needed. The intersection of new technologies and philosophical stances that upend human-centered views of reality suggests that creativity is not an exclusively “human” activity. This opens new possibilities and assemblages for conceiving of creativity, but not without tensions. In this article, we connect multiple threads, to reimagine creativity in light of posthuman understandings and the possibilities for creative emergence beyond the Anthropocene. Creativity is implicated as emerging beyond non-human spaces, such as through digitality and AI or sources in the natural world. This unseats many understandings of creativity as positioned in Euro-Western literature. We offer four areas of concern for interrogating tensions in this area, aiming to open new possibilities for practice, research, and (re)conceptualization beyond Western understandings.

General Engineering, Pathology, General Surgery, Oncology, neural crest tumor, neurogenic tumor, lower abdominal pain, retroperitoneal mass, and ganglioneuroma

Ganglioneuromas are rare benign neoplasms arising from neural crest tissue. They are a subtype of neurogenic tumors with ganglion cell origin. They are most commonly found in the retroperitoneum and posterior mediastinum. Most ganglioneuromas are found incidentally; most patients are asymptomatic, and it rarely causes symptoms, which are often induced by compression. Here we present a case of a 24-year-old lady, who was investigated for right lower abdominal pain and found to have a right retroperitoneal solid mass at the level of L5-S1, which was displacing the major vessels. The patient underwent open excision of the mass.

cardiovascular diseases, cardiovascular system, nervous system diseases, and circulatory and respiratory physiology

Constriction of the large and medium-sized cerebral arteries following an aneurysmal subarachnoid haemorrhage (aSAH) is a well-known condition that primarily affects the anterior circulation supplied by the internal carotid arteries. SAH is a rare but potentially fatal type of stroke. Across the literature, authors have defined vasospasm using terms such as "symptomatic vasospasm," "delayed cerebral ischemia" (DCI), "transcranial Doppler vasospasm," and "angiographic vasospasm." Because posthemorrhagic vasospasm causes significant neurologic morbidity and death, there has been a great deal of interest and research into its physiologic basis and developing effective preventative and treatment strategies. The triple-H therapy hemodynamic augmentation technique, which includes hypertension, hemodilution, and hypervolemia, has been an important part of the treatment. In this article, we'll look at cerebral vasospasm following subarachnoid haemorrhage, including its causes, epidemiology, evaluation, and, most importantly, management.