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Computer Science Applications and Education

Neurology and Neurology (clinical)

History and Philosophy of Science, Arts and Humanities (miscellaneous), Political Science and International Relations, and Social Sciences (miscellaneous)

Algorithms reflect how power is arranged within our society while also producing power dynamics themselves. Algorithmic systems configure power by engaging in network-making, thereby shaping society and entrenching existing logics into infrastructure. To understand the moral economy of high-tech modernism, we must explore how algorithmic systems contribute to ongoing social, political, and economic structuring. This essay reflects on the importance of algorithmic systems’ positions within our political, economic, and social arrangements.

General Chemistry

The main strategies for the synthesis of Peptide Nucleic Acids (PNAs): key molecules as DNA/RNA mimics that can hybridize complementary chains of nucleic acids with high affinity and specificity.

Education

In this special issue of the Australasian Journal of Educational Technology, we take a step back from the events of the last 2 years and the changes that we have seen in the education arena, to remember that which has remained constant – how students learn best. Developing teaching and learning pedagogy based on lasting education theory and practice makes the past of education relevant to the present and future and creates a context where innovation can be scaled and taken further, from a single instance of impact to many. In this editorial, we present an argument for going back to our roots and present examples of the effective use of established theories of learning that continue to advance online education practice. We discuss the scaling of educational best practice to more students and more institutions, and we provide recommendations for creating sustainable and lasting future practice.

Computer Science Applications and Education

Heart Failure, Mice, Inbred C57BL, Mice, Ventricular Remodeling, Myocardium, Animals, Cardiomegaly, Fibroblasts, Myofibroblasts, Cardiology and Cardiovascular Medicine, and Fibrosis

Aims In response to pro-fibrotic signals, scleraxis regulates cardiac fibroblast activation in vitro via transcriptional control of key fibrosis genes such as collagen and fibronectin; however, its role in vivo is unknown. The present study assessed the impact of scleraxis loss on fibroblast activation, cardiac fibrosis, and dysfunction in pressure overload-induced heart failure. Methods and results Scleraxis expression was upregulated in the hearts of non-ischemic dilated cardiomyopathy patients, and in mice subjected to pressure overload by transverse aortic constriction (TAC). Tamoxifen-inducible fibroblast-specific scleraxis knockout (Scx-fKO) completely attenuated cardiac fibrosis, and significantly improved cardiac systolic function and ventricular remodelling, following TAC compared to Scx+/+ TAC mice, concomitant with attenuation of fibroblast activation. Scleraxis deletion, after the establishment of cardiac fibrosis, attenuated the further functional decline observed in Scx+/+ mice, with a reduction in cardiac myofibroblasts. Notably, scleraxis knockout reduced pressure overload-induced mortality from 33% to zero, without affecting the degree of cardiac hypertrophy. Scleraxis directly regulated transcription of the myofibroblast marker periostin, and cardiac fibroblasts lacking scleraxis failed to upregulate periostin synthesis and secretion in response to pro-fibrotic transforming growth factor β. Conclusion Scleraxis governs fibroblast activation in pressure overload-induced heart failure, and scleraxis knockout attenuated fibrosis and improved cardiac function and survival. These findings identify scleraxis as a viable target for the development of novel anti-fibrotic treatments.

Pharmaceutical Science and Pharmacy

Architecture, Building and Construction, self-healing concrete, finite element modeling, structural resilience, sustainability, and Civil and Structural Engineering

The formation of cracks in concrete structures occurs due to a multitude of causes ranging from shrinkage to external loading and environmental exposure. This phenomenon can significantly affect the lifecycle of concrete structures. Self-healing concrete (SHC) is considered a promoted innovation capable of overcoming this inevitable occurrence. In accordance with current SHC development processes, this paper utilizes the numerical simulation approach to test the performance of reinforced SHC beam specimens modeled using the commercial software ABAQUS 6.14 (Vélizy-Villacoublay, France). This paper aims to contribute to the scarce literature on SHC models by utilizing the overlooked dicyclopentadiene (DCPD) agent and ambiguous variability of crystalline admixtures. The SHC is introduced to the beam models at various depths and analyzed using load against displacement curves compared with a reference model of ordinary concrete. The effects of SHC on the mechanical properties of structural elements were determined. The results show a distinct improvement of the load-carrying capacity of SHC beams, indicating an efficient contribution of SHC in structural applications.

Computer Science Applications and Education

Computer Science Applications and Education

Fuel Technology and Analytical Chemistry

Physiology (medical) and Cardiology and Cardiovascular Medicine

Choosing a future career path is a very important decision for undergraduate medical students. Determining the factors that affect specialty choices is essential to attaining a balanced distribution. Dermatology is known to be one of the most appealing and highly competitive specialties. The aim of this study was to determine the factors influencing the choice of dermatology as a future career by medical students.A cross-sectional study was carried out in 28 medical schools throughout Saudi Arabia. The questionnaire was prepared following a literature search of relevant studies and was distributed electronically to medical students and interns. The self-administered questionnaire included sociodemographic data, interest in dermatology as a future career, and factors that may affect specialty choices.The study included 1087 participants. Sixty percent were female, and 39% were male. Approximately half of the participants considered dermatology as their preferred specialty. We found that 53.6% of females were more interested in dermatology. Students who were exposed to dermatology in both pre-clinical and clinical years showed greater interest. Personal interest, lifestyle/flexible work schedule, and private sector opportunities were the most captivating factors. Personal interest and high competition in dermatology residency program matching were the main factors among students who did not consider dermatology as a future career choice.Several factors are influencing medical students when choosing dermatology as their future specialty; the lifestyle/flexible work schedule and personal interest were the most attractive factors. Recognizing these factors could be a useful tool that may lead mentors and residency training program directors to reach a balanced distribution of doctors in the various specialties.

Cultural Studies, arts and design, mindfulness, Sociology and Political Science, meditation, Political Science and International Relations, college students, ComputingMilieux_COMPUTERSANDEDUCATION, and creativity

Given the applied nature of creativity in the arts and design, it is important to understand the conditions and practices that support it. Most research suggests that ideal conditions for creativity are often mental and emotional – involving relaxed, yet alert and focused, states of mind. This article explores the connection between mindfulness and creativity in the experiences of students in a college of arts and design, through a mindfulness teaching practice to support creative processes. In a “scholarship of teaching and learning” inquiry, we consider how mindfulness practice may affect arts and design learners’ feelings about their own creativity. Students in a large United States university school of arts and design practiced mindfulness meditation for several months, and submitted a written reflection on their experience. We qualitatively analyze this to consider how mindfulness supports creative practices in arts and design learners’ education. Our findings involve three key themes, which are: “Processing anxiety and negative feelings”, “Focusing the mind”, and “Managing the ‘Voice of Judgment’”. These thematic findings reflect how arts and design students perceive the effects of mindfulness on their creative process. We offer implications for teaching practices related to mindfulness meditation practice aimed to support learners’ perceptions of their creativity.