Algawiaz, Danah, Dobbie, Gillian, and Alam, Shafiq
2019 IEEE 14th International Conference on Intelligent Systems and Knowledge Engineering (ISKE) Intelligent Systems and Knowledge Engineering (ISKE), 2019 IEEE 14th International Conference on. :324-328 Nov, 2019
Makhalfih, Asaad, Braik, Amer, Barakat, Danah, and Kahtib, Tamer
2017 14th International Conference on Smart Cities: Improving Quality of Life Using ICT & IoT (HONET-ICT) Smart Cities: Improving Quality of Life Using ICT & IoT (HONET-ICT), 2017 14th International Conference on. :40-44 Oct, 2017
Filia Garivaldis, Stephen McKenzie, Danah Henriksen, and Sylvie Studente
Australasian Journal of Educational Technology. 38:1-11
In this special issue of the Australasian Journal of Educational Technology, we take a step back from the events of the last 2 years and the changes that we have seen in the education arena, to remember that which has remained constant – how students learn best. Developing teaching and learning pedagogy based on lasting education theory and practice makes the past of education relevant to the present and future and creates a context where innovation can be scaled and taken further, from a single instance of impact to many. In this editorial, we present an argument for going back to our roots and present examples of the effective use of established theories of learning that continue to advance online education practice. We discuss the scaling of educational best practice to more students and more institutions, and we provide recommendations for creating sustainable and lasting future practice.
Raghu S Nagalingam, Sikta Chattopadhyaya, Danah S Al-Hattab, David Y C Cheung, Leah Y Schwartz, Sayantan Jana, Nina Aroutiounova, D Allison Ledingham, Teri L Moffatt, Natalie M Landry, Rushita A Bagchi, Ian M C Dixon, Jeffrey T Wigle, Gavin Y Oudit, Zamaneh Kassiri, Davinder S Jassal, and Michael P Czubryt
European Heart Journal. 43:4739-4750
Cardiology and Cardiovascular Medicine
Aims In response to pro-fibrotic signals, scleraxis regulates cardiac fibroblast activation in vitro via transcriptional control of key fibrosis genes such as collagen and fibronectin; however, its role in vivo is unknown. The present study assessed the impact of scleraxis loss on fibroblast activation, cardiac fibrosis, and dysfunction in pressure overload-induced heart failure. Methods and results Scleraxis expression was upregulated in the hearts of non-ischemic dilated cardiomyopathy patients, and in mice subjected to pressure overload by transverse aortic constriction (TAC). Tamoxifen-inducible fibroblast-specific scleraxis knockout (Scx-fKO) completely attenuated cardiac fibrosis, and significantly improved cardiac systolic function and ventricular remodelling, following TAC compared to Scx+/+ TAC mice, concomitant with attenuation of fibroblast activation. Scleraxis deletion, after the establishment of cardiac fibrosis, attenuated the further functional decline observed in Scx+/+ mice, with a reduction in cardiac myofibroblasts. Notably, scleraxis knockout reduced pressure overload-induced mortality from 33% to zero, without affecting the degree of cardiac hypertrophy. Scleraxis directly regulated transcription of the myofibroblast marker periostin, and cardiac fibroblasts lacking scleraxis failed to upregulate periostin synthesis and secretion in response to pro-fibrotic transforming growth factor β. Conclusion Scleraxis governs fibroblast activation in pressure overload-induced heart failure, and scleraxis knockout attenuated fibrosis and improved cardiac function and survival. These findings identify scleraxis as a viable target for the development of novel anti-fibrotic treatments.
Asim Ahmed Elnour, Nadia Sarfaraz Raja, Fatemeh Abdi, Fariha Mostafiz, Razan Isam Elmubarak, Alaa MohsenQ Khalil, Khawla Abou Hait, Mariam Mohamed Alqahtani, Nour Dabbagh, Zainab Abdulnasser, Danah Albek, Abdelfattah Amer, Nosayba Al Damook, Aya Shayeb, Sara Alblooshi, Mohammed Samir, Abdallah Abou Hajal, Nora Al Barakani, Rahf Balbahaith, Hamda Al Mazrouie, and Rahaf Ahmed Ali
Phonetics plays a major role in the fabrication of prostheses. This study aimed to assess the knowledge of students regarding the role of phonetics in denture fabrication and to improve the educational process and the clinical application. The study was conducted at the College of Dentistry, Imam Abdulrahman Bin Faisal University, and involved a survey of 344 dental students and interns. The questionnaire contained 20 questions and was divided into three sections: general knowledge, clinical correlations, and clinical evaluations. The data were collected and analyzed statistically using independent t-tests, one-way ANOVA, and Tukey’s post hoc tests. The response rate was 100%. Male and female students only differed significantly in terms of their scores for answers to general knowledge questions, with females achieving better results (p = 0.023). General knowledge varied significantly between fourth-year students and all other levels (p < 0.001), and fifth-year students and interns (p = 0.027). The clinical correlations varied significantly between fourth-year students and interns (p = 0.01), whereas the clinical evaluations varied between all the academic years and interns (fourth-year, p < 0.001; fifth-year, p = 0.003; and sixth-year, p = 0.017). The interns obtained the highest scores in all sections. There was a lack of awareness among dental students of some aspects of the role of phonetics in denture fabrication. The study highlights the deficiencies that need to be addressed and the need for adjustments to the curriculum related to removable prosthodontics in order to improve the knowledge of students regarding the role of speech in denture fabrication.