Recently, a great amount of attention --both scholarly and popular--has been focused on implementing design thinking in schools (Norton Hathaway, 2015). A recent piece in The Atlantic, for example, notes [...]
Al-Shamary, Danah S., Al-Alshaikh, Monirah A., Kheder, Nabila Abdelshafy, Mabkhot, Yahia Nasser, and Badshah, Syed Lal
Chemistry Central Journal. May 31, 2017, Vol. 11 Issue 1
Organic compounds -- Research, Cancer -- Care and treatment, and Cancer -- Research
Author(s): Danah S. Al-Shamary[sup.1], Monirah A. Al-Alshaikh[sup.1], Nabila Abdelshafy Kheder[sup.2,3], Yahia Nasser Mabkhot[sup.4] and Syed Lal Badshah[sup.5] Background The quinazoline moiety containing compounds is of considerable medicinal importance because of [...] Background The quinazoline are an important class of medicinal compounds that possess a number of biological activities like anticancer, anticonvulsant and antioxidant etc. Results We evaluated the previously synthesized quinazoline derivatives 1-3 for their anticancer activities against three cancer cell lines (HepG2, MCF-7, and HCT-116). Among the tested compounds, quinazolines 1 and 3 were found to be more potent than the standard drug Vinblastine against HepG2 and MCF-7 cell lines. All the tested compounds had less antioxidant activity and did not exhibit any anticonvulsant activity. Also, molecular docking studies were performed to get an insight into the binding modes of the compounds with human cyclin-dependent kinase 2, butyrylcholinesterase enzyme, human gamma-aminobutyric acid receptor. These compounds showed better docking properties with the CDK2 as compared to the other two enzymes. Conclusions The overall study showed that thioxoquinazolines are suitable antitumor agents and they should be explored for other biological activities. Modification in the available lot of quinazoline and synthesis of its novel derivatives is essential to explore the potential of this class of compounds. The increase in the threat and with the emergence of drug resistance, it is important to explore and develop more efficacious drugs. Keywords: Thioxoquinazolin-4(3H)-one, Anticancer activity, Antioxidant activity, Anticonvulsant activity, Molecular docking
Technology application, Teenagers -- Technology application, Youth -- Technology application, Parenting -- Technology application, and Social media -- Usage
Social media and smartphone applications have turned into an avenue for teenagers to explore their identity and the world around them. Fearful parents tend to track, monitor and block their teenagers' access to the Internet and impose more restrictions. Such parenting techniques do not help teenagers develop the skills necessary to manage complex social situations. Teenagers need the freedom to navigate the digital world but they also need to be aware that their parents are interested in knowing what they do online.
Social Forces. June 2010, Vol. 88 Issue 4, p1936, 3 p.
Books -- Book reviews and Portable Communities: The Social Dynamics of Online and Mobile Connectedness (Nonfiction work) -- Book reviews
Portable Communities: The Social Dynamics of Online and Mobile Connectedness By Mary Chayko SUNY Press. 2008. 318 pages. $74.50 cloth, $24.95 paper. There is little doubt that networked technologies have [...]
Tikkun. Sept-Oct, 2004, Vol. 19 Issue 5, p40, 5 p.
Spirituality -- Social aspects, Spirituality -- Political aspects, United States -- Political aspects, and United States -- Social aspects
The upcoming November presidential election is one of the most crucial in American history. The electorate is divided nearly 50/50 for and against the Bush administration along bitter emotional, economic, [...]