The discovery and development of effective chemotherapeutic agents in the past few decadeshave immensely enhanced the treatment and management of human cancer. However, becausethese drugs are associated with adverse side effects, high genotoxicity, risk for secondary cancersand devastating effects on the patients’ immune system; the need for developing more effectiveanticancer agents remains. A priority Research shows that 9-aminoacridine (9AA) derivativeshave substantial anticancer properties. The pharmacological properties of this agent are wellcharacterized and this scaffold has been widely used to treat different diseases for decades.Quinacrine is a 9AA derivative, which was first discovered as an antimalarial compound in1930’s and since then had been widely used in treating a variety of parasitic infections anddemonstrated potential for cancer treatment. Importantly, the polypharmacology of Quinacrinemakes it an attractive drug to treat a variety of cancers. Quinacrine acts by specifically targetingcellular signaling pathways that play an important role in cell survival. Given the distinctivecancer treating abilities of Quinacrine by specifically targeting cellular signaling pathways, itwas the objective of this study to develop a compound that has similar properties as Quinacrinebut has better efficacy and selectivity in targeting tumor cells. Therefore, for this project wecreated derivatives of 9AA compound using hybrid pharmapore approach and examined one ofthe derivatives of Quinacrine compound named VR118. After performing a series of experimentsto test the efficacy and selectivity of the Quinacrine derivative VR118, I came to the conclusionthat VR118 is highly effective in treating cancer cells and have the potential to selectively targetcancer cells without causing severe harm to normal cells at concentrations applicable formalignant cell lines. This report discusses the efficacy and selectivity of VR118 compound intargeting cellular signaling pathways and the mechanisms through which VR118 kills cancercells.
Behavioral Coaching, Skill Acquisition, Sport, and Behavioral Disciplines and Activities
Behavioral coaching procedures have been evaluated and enhanced over the years to find the most effective interventions for athletic performance in a variety of sports settings. Different types of feedback have been evaluated for effectiveness in teaching and improving skills. The purpose of this study was to examine the effects of video modeling and video feedback to improve technique for three novice individuals in a fitness program incorporating Olympic weightlifting. Two weightlifting events, the clean and jerk and snatch, were targeted for intervention. Each lift was broken down into a task analysis, and trainers used the task analysis to score each lift. Video modeling and video feedback was effective in improving all three participant's lifts from baseline. Annie's lifts improved from 37% in baseline to 79% in intervention for the clean and jerk, and 24% to 75% for the snatch. Rich's lifts improved from 79% in baseline to 95% following intervention for clean and jerk, and 58% to 89% for the snatch. Fran improved from 60% to 87% on the clean and jerk, and from 51% to 84% on the snatch.
Jet Effects, Increased Circulation, and Flow Control Method
The work reflected in this thesis includes a detailed study of co-flow jet (CFJ) technologies as they are applied to a typical thin airfoil, NACA 6415, at take-off and landing speeds. Numerical analysis and experimental testing were conducted on baseline and co-flow jet airfoils of the same plan form. The CFJ mechanism employs high pressure air injected along the span at the leading edge while a low pressure source removes the same amount of air along the span at the trailing edge. Hence, the net mass flux of the system is zero energy loss is minimized. The jet produced along the upper surface of the airfoil mixes with and excites the free stream flow resulting in increased lift, augmented stall margin, and decreased drag. At certain angles of attack the decreased drag is negative and thrust is produced. The research was comprised of four phases including computational fluid dynamics (CFD) simulations, design and manufacturing of a transformable baseline and adjustable slot size CFJ airfoil, implementation of a CFJ Wind Tunnel Laboratory, and wind tunnel testing. A computational fluid dynamics code, developed at the University of Miami, was used to study flow fields and to obtain analytical results of aerodynamic properties for the baseline and CFJ airfoils. Modeling of both wing shapes utilized the baseline ordinates of a cambered NACA 6415 airfoil. The free stream steady state flow was set to Mach=0.1 to simulate take-off and landing speeds where the co-flow jet mechanism would demonstrate its largest increase in performance. CFD simulations of both models provided aerodynamic coefficients as well as mass flow and jet effect data specifically useful to the CFJ airfoil. The NACA 6415 model used for wind tunnel testing was designed and produced to provide both baseline and CFJ results with adjustable injection and suction slot sizes. Connections for a side-mounted force balance and an air delivery system for the co-flow jet were included in the airfoil model. The design and manufacturing of a wind tunnel test section extension was necessary to provide support for the additional aerodynamic loads induced by the CFJ airfoil and to house various air connections and test sensors. A CFJ Wind Tunnel Laboratory was designed and constructed during the course of the research and included selection of proper air delivery apparatus for the injection and suction air for the CFJ jet. All testing controls and sensor equipment were acquired and installed to obtain various data needed for experimental analysis. Finally, a data acquisition system was designed to consolidate all testing information for ease of use. Wind tunnel testing of the baseline and CFJ airfoils provided the aerodynamic loads and coefficients needed to demonstrate the performance enhancements of the co-flow jet flow control method. Experimental and numerical results were examined to understand the benefits of the co-flow jet as it compares to a similar baseline airfoil. The CFD simulations and experimental measurements agree fairly well. All results indicate that the CFJ flow control method is very effective for a typical thin airfoil with 15% maximum thickness.
by Danah Boyd. Thesis (S.M.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2002. Includes bibliographical references (leaves 113-118).