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The papers primarily consist of correspondence, diaries, and medical notes. Most of the letters were written by Wilson Yandell, Lunsford Pitts Yandell, Susan Wendell Yandell, and Lunsford Pitts Yandell, Jr. The letters consist mostly of family news but also contain information relating to a variety of other topics, including medical practice, physicians of Ky., medical politics at Transylvania and the Louisville Medical Institute, state politics and economic conditions in Ky. and Tenn., references to important citizens in Louisville and Lexington, the career of David W. Yandell, disease, slavery, the secession crisis, and the Civil War. In addition to correspondence, the collection also includes lectures of Lunsford P. Yandell, material about his father Wilson Yandell, notes for medical biographies, diaries of Lunsford P. Yandell, and a scrapbook. Correspondents include Elisha Bartlett, Charles Caldwell, Daniel Drake, Austin Flint, Timothy Flint, Samuel D. Gross, Philip Lindsley, Henry Miller, and Benjamin Rush.