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1. Book Review: Art. [1978]

  • Hausman, Patricia R., Sisson, Jacqueline D., DeCandido, GraceAnne A., Bond, Randall I., Huemer, Christina, Kaplan, Robin, Pollard, Elizabeth B., Miller, Marjorie, von Khrum, Paul, and Reister, Willa
  • Library Journal. 6/1/1978, Vol. 103 Issue 11, p1162. 3p.

2. Effect of dietary cholesterol on plasma cholesterol concentration in subjects following reduced fat, high fibre diet. [1987]

  • Edington, Jacqueline, Geekie, Moira, Carter, Robin, Benfield, Lisa, Fisher, Karen, Ball, Madeleine, and Mann, Jim
  • British Medical Journal (Clinical Research Edition). 2/7/1987, Vol. 294 Issue 6568, p333-336. 4p. 1 Diagram, 4 Charts.
Subjects
LOW-fat diet and BLOOD cholesterol
Abstract
Examines the effect of dietary cholesterol on plasma cholesterol concentration in subjects following low fat diet in Great Britain. Ratio of polyunsaturated to saturated fatty acids; Comparison of the cholesterol concentration among subjects; Importance of dietary cholesterol for the reduction of saturated fats.

3. Shape preferences for simple Euclidian forms in three age groups [1989]

  • Silver, Annabelle, Combs, Allan, McConnellogue, Janet, Johnson, Robin, Pickering, John, and Hicks, Jacqueline
  • Perceptual and Motor Skills. April 1989, Vol. 68 Issue 2, p522, 1 p.
Subjects
Testing, Research, Age groups -- Testing, Intelligence (Psychology) -- Testing, Form perception (Psychology) -- Research, Age and intelligence -- Testing, and Form perception -- Research

4. Serum lipid response to dietary cholesterol in subjects fed a low-fat, high-fiber diet [1989]

  • Edington, Jacqueline D., Geekie, Moira, Carter, Robin, Benfield, Lisa, Ball, Madeleine, and Mann, Jim
  • American Journal of Clinical Nutrition. July 1989, Vol. 50 Issue 1, p58, 5 p.
Subjects
Health aspects, Physiological aspects, Research, Control, Hyperlipoproteinemia -- Health aspects, Cholesterol -- Physiological aspects, Low cholesterol diet -- Research, Blood cholesterol -- Control, and Low-cholesterol diet -- Research
Abstract
Both cholesterol and saturated fat in the diet have been linked to increased risk of coronary artery disease. Dietary cholesterol and saturated fat appear to contribute to heart disease by raising blood cholesterol. The elevated circulating cholesterol may adhere to the inner walls of the coronary arteries, slowing or blocking blood flow. While dietary cholesterol is only found in animal foods such as meat, eggs and dairy products, saturated fat may be found in animal or vegetable foods. Persons who wish to reduce their risk of heart disease are usually advised to make several changes in their diet: reduce cholesterol, reduce saturated fat, and increase fiber. The 58 participants followed a low-saturated-fat, high-fiber diet throughout the 12 weeks. To this background diet were added nine eggs per week for the first four weeks, zero eggs for the second four weeks and nine eggs per week for the last four weeks. Eggs were used as a source of cholesterol. The participants' blood cholesterol levels did not change significantly when the number of eggs was changed from nine to zero and back to nine. The subjects showed no consistent evidence of 'hyperresponse', defined as a greater than average increase in blood cholesterol in response to a given increase in dietary cholesterol. It is concluded that once a person is eating a low-saturated-fat, high-fiber diet, reducing dietary cholesterol to below 400 mg per day provides little additional benefit in terms of lowering blood cholesterol. A cholesterol intake of 400 mg per day is considered moderate and was provided in the diet containing nine eggs per week. When subjects added zero eggs to the background diet they consumed 90 mg cholesterol per day.

5. AFTER THE LOVING, COUNTING THE COST Boy meets girl, boy loses girl, girl gets revenge: Some landmark cases in which famous ex-spouses gained millions from marital pain. [1989]

  • Schindehette, Susan, Micheli, Robin, Sheff, Vicki, Savaiano, Jacqueline, Knapp, Dan, Bacon, Doris, Demaret, Kent, McNeil, Liz, and Waggoner, Dianna
  • People. 8/7/89, Vol. 32 Issue 6, p68. 1p.

6. NEWS & Political Review. [1992]

  • Kingman, Sharon, Yamauchi, Masaya, Dorozynski, Alexander, Swan, Norman, McBride, Gail, Karcher, Helmut L., Godlee, Fiona, Annis, Jacqueline, Gloag, Daphne, Lowry, Stella, Warden, John, Dyer, Clare, Williams, Robin, Greenhill, Sally, and Greenhill, Richard
  • BMJ: British Medical Journal (International Edition). 3/7/92, Vol. 304 Issue 6827, p591. 6p. 4 Black and White Photographs, 1 Diagram.
Subjects
MEDICINE, FETAL tissue research, POPULATION & the environment, FETAL death, and POLITICAL science
Abstract
Presents global developments on the political aspects of medicine as of March 1992. Progress on fetal tissue research and transplants in Australia, Europe, and the United States; Increase in human population; Disposal of fetuses and fetus remains.

7. Excavation and Survey at Watchfield, Oxfordshire, 1983-92. [1992]

  • Scull, Christopher, Ager, Barry, Bourn, Robert, Cameron, Esther, Clogg, P. W., Creighton, John, Edwards, Glynis, Gelling, Margaret, Gilmour, Brian, Harman, Mary, Henry, Pippa, Holgate, Robin, Huntley, Jacqueline P., Johnson, Paul, Linford, Neil, Marlow, C. A., Mortimer, Catherine, Mudd, Andrew, Odenstedt, Bengt, and Page, R. I.
  • Archaeological Journal. 1992, Vol. 149, p124-281. 158p. 13 Black and White Photographs, 66 Diagrams, 12 Charts, 2 Graphs, 2 Maps.
Subjects
ARCHAEOLOGICAL excavations, ARCHAEOLOGICAL surveying, ARCHAEOLOGY, INTERMENT, and IRON Age
Abstract
Geophysical survey and excavation have demonstrated that iron age settlement features and early Anglo-Saxon burials discovered during road construction in 1983 were part o[ an extensive multi-period site, now a Scheduled Ancient Monument. This paper presents the results of the archaeological investigations. The bulk of the report is concerned with the early Anglo-Saxon burials, which included a grave containing a balance, weights and runic inscription. The evidence for late mesolithic, neolithic -- early bronze age, iron age and post-medieval activity is also discussed, and the site is considered in its regional and wider context. [ABSTRACT FROM AUTHOR]

8. Nonsteroidal signals originating in the gonads [1992]

  • Ackland, Jacqueline F., Schwartz, Neena B., Mayo, Kelly E., and Dodson, Robin E.
  • Physiological Reviews. July 1992, Vol. 72 Issue 3, p731, 57 p.
Subjects
Physiological aspects, Evaluation, Gonads -- Physiological aspects, Ovaries -- Physiological aspects, Testis -- Physiological aspects, Sex hormones -- Physiological aspects, Peptide hormones -- Evaluation, and Hormones, Sex -- Physiological aspects
Abstract
The various peptide factors produced in the testes and ovaries are reviewed. Chemical isolation, purification, and amino acid and nucleotide sequencing have led to the understanding of the mechanisms of actions of these nonsteroidal agents. Among the gonadal peptides identified are inhibin, relaxin, oocyte meiosis inhibitor and growth factors. The study of the functions of these peptides have led to the identification of other proteins such as luteinizing inhibitor and clusterin. Immunological or molecular probes were also able to detect factors originally identified in other glands such as propiomelanocortin and atrial natriuretic factor.

9. On winning friends and influencing people: action identification and self-presentation success [1992]

  • Vallacher, Robin R., Wegner, Daniel M., McMahan, Susan C., Cotter, Jacqueline, and Larsen, Kathleen A.
  • Social Cognition. Fall, 1992, Vol. 10 Issue 3, p335, 21 p. graph
Subjects
Self-presentation -- Research, Identification (Psychology) -- Research, and Social psychology -- Research
Abstract
Eighty undergraduate students were asked to describe themselves using high-level or low-level terms of action identification theory and self-presentation. The subjects were told that they were trying to impress an easily-impressionable person or a difficult-to-impress person. Ratings made by the subjects and observers showed that low-level terms of action identificationtheory and self-presentation such as smiling when appropriate, were more effective in terms of getting positive first impressions.

10. Characteristics relating to ovarian cancer risk: collaborative analysis of seven U.S. case-control studies. Epithelial ovarian cancer in black women [1993]

  • John, Esther M., Whittemore, Alice S., Harris, Robin, and Itnyre, Jacqueline
  • Journal of the National Cancer Institute. Jan 20, 1993, Vol. 85 Issue 2, p142, 6 p.
Subjects
Risk factors, Health aspects, Research, Ovarian cancer -- Risk factors, African American women -- Health aspects, Oral contraceptives -- Health aspects, Breast feeding -- Health aspects, and Disease susceptibility -- Research
Abstract
Background: Previous epidemiologic studies of ovarian cancer have focused chiefly on White women, who have a higher incidence of ovarian cancer than Black women. No study has previously examined risk factors for ovarian cancer among Black women. Purpose: This study was designed to evaluate the risk of epithelial ovarian cancer in Black women in relation to reproductive characteristics such as pregnancy, oral contraceptive use, and breast-feeding, and to determine whether differences in reproductive factors between Black and White women account for differences in ovarian cancer incidence. Methods: Combining interview data from seven case-control studies, we compared reproductive characteristics of 110 Black case subjects with a diagnosis of epithelial ovarian cancer between 1971 and 1986 with characteristics of 251 Black population control subjects and 114 Black hospital control subjects. We also compared the prevalence of reproductive factors in 246 Black population control subjects and 4378 White population control subjects and estimated the fraction of Black-White differences in ovarian cancer incidence attributable to racial differences in prevalence of these characteristics. Results: Decreased risks of epithelial ovarian cancer in Black women were associated with parity of four or higher (odds ratio [OR] = 0.53; 95% confidence interval [CI] = 0.25-1.1), breast-feeding for 6 months or longer (OR = 0.85; 95% CI = 0.36-2.0), and use of oral contraceptives for 6 years or longer (OR = 0.62; 95% CI = 0.24-1.6). A greater proportion of Black women (48%) than White women (27%) reported four or more term pregnancies, and Black women (62%) were more likely than White women (53%) to have breast-fed their children. Oral contraceptive use was more common among White women (59%) than Black women (51%). Conclusion: Differences in the prevalence of other factors related to ovarian cancer risk or differences in genetic susceptibility must explain most of the Black-White differences in incidence of ovarian cancer. [J Natl Cancer Inst 85:142-147, 1993]

11. Public health interests in trade agreements on alcoholic beverages in North America [1993]

  • Ferris, Jacqueline, Room, Robin, and Giesbrecht, Norman
  • Alcohol Health & Research World. Summer 1993, Vol. 17 Issue 3, p235, 7 p.
Subjects
International trade, Laws, regulations and rules, Alcoholic beverage industry -- International trade, International trade regulation, and International trade -- Laws, regulations and rules
Abstract
Public health often conflicts with economic benefit in trade agreements covering alcoholic beverages. In North America, states and provinces tend to bear the brunt of costs. Several alcohol trade and marketing agreements are discussed.

12. New barriers to ventricular invasion in paraglottic laryngeal cancer [1994]

  • Beitler, Jonathan J., Mahadevia, Panna S., Silver, Carl E., Wadler, Scott, Rubin, John S., Bello, Jacqueline A., Mitnick, Robin J., and Vikram, Bhadrasain
  • Cancer. May 15, 1994, Vol. 73 Issue 10, p2648, 5 p.
Subjects
Physiological aspects, Development and progression, Cancer invasiveness -- Physiological aspects, and Laryngeal cancer -- Development and progression
Abstract
Background. Anatomic barriers to the spread of laryngeal cancer include the conus elasticus, the quadrangular membrane, and the thyroid cartilage. It has been speculated that an elastic barrier surrounds and protects the ventricle. Methods. The authors studied the microanatomic patterns of spread of 17 cases of patients who had laryngeal cancer with paraglottic disease and confirmed their findings by examining normal autopsy specimens. Results. Five patients of the seventeen cases showed no ventricular mucosal involvement despite extensive paraglottic disease. Both an inner, central, subepithelial periventricular elastic barrier, and a more peripheral periventricular elastic membrane barrier were identified; the latter was in continuity with the conus elasticus and quadrangular membrane. Conclusions. Two weak fibroelastic barriers surround the ventricle. The outer, peripheral, fibroelastic membrane is contiguous with the conus elasticus and the quadrangular membrane. Therefore, ventricular involvement is not a sensitive indicator of paraglottic spread. Squamous cell cancer may grow around the periventricular barriers to involve both the true and false cords but may spare the ventricle. The prognostic significance of the violation or preservation of the periventricular elastic barriers is unknown.

13. Developmental expression of the sea urchin egg receptor for sperm [1994]

  • Ohlendieck, Kay, Partin, Jacqueline S., Stears, Robin L., and Lennarz, William J.
  • Developmental Biology. Sept, 1994, Vol. 165 Issue 1, p53, 10 p. photograph
Subjects
Sea urchins -- Eggs and Spermatozoa -- Analysis
Abstract
Western and Northern blot analyses and immunocytochemistry of the sea urchin egg receptor for sperm to study the receptor expression during oogenesis indicate that in the last two developmental phases of oogenesis the receptor mRNA level exhibits a very high increase despite the absence of receptor glycoprotein or receptor mRNA in the early oocytes. The development of receptor occurs in association with the spatial and temporal formation of cortical granules. Development of the receptor in the late stages and its localization to the cell surface and cortical granules indicates that the receptor mediates attachment of sperm to the surface of the mature egg cell.

14. The risk of harm to oneself from drinking, Canada 1989. [1995]

  • Room, Robin, Bondy, Susan J., and Ferris, Jacqueline
  • Addiction. Apr1995, Vol. 90 Issue 4, p499-513. 16p. 4 Charts, 5 Graphs.
Subjects
ALCOHOL drinking
Abstract
In a national sample of 11 634 Canadians aged 15 years and above, risk curves for harm to six life-areas from one's own drinking and for assault by another drinker rose steadily with the respondent's volume of alcohol consumption. While drinking five or more drinks on an occasion at least once a month substantially raised the risk at a given volume of drinking, the risk rose with volume even among those not regularly drinking five or more drinks. These relationships remained in logistic regressions which controlled for gender, age and educational level. Younger respondents, those without higher education and men reported more harm for a given level of their own drinking although differences by gender disappeared above one-third of one drink per day. Three sets of guidelines for low-risk drinking-two from Canada, and one generally used in Britain-were compared in terms of the proportions of respondents reporting harm from their own drinking among those who had kept within the guideline in the previous 7 days' drinking. More restrictiveness in the guidelines was associated with substantial reductions in reported drinking-related harm. [ABSTRACT FROM AUTHOR]

15. Ambiguity and underwriter decision processes [1995]

  • Kunreuther, Howard, Meszaros, Jacqueline, Hogarth, Robin M., and Spranca, Mark
  • Journal of Economic Behavior & Organization. May 1995, Vol. 26 Issue 3, p337, 1 p.
Subjects
Ambiguity -- Economic aspects, Decision-making -- Research, Insurance industry -- Psychological aspects, and Risk assessment -- Psychological aspects
Abstract
Research is presented demonstrating the impact of ambiguity and risk on the insurance pricing decisions of underwriters. Premiums are shown to be substantially higher where there is uncertainty about potential loss levels and where the probability of an event occurring is ambiguous.

16. Three tips for saving mice. [1995]

  • Seewald, Jacqueline and Harris, Robin
  • Technology Connection. Oct95, Vol. 2 Issue 6, p8. 1/2p.
Subjects
MICE (Computers)
Abstract
Offers advice on how to prevent removal of a computer mouse's trackball. Dabbing super glue on the inside lid; Locking the trackball retaining ring into the mouse.

17. An evaluation of peer and professional trainers in a union-based occupational health and safety training program [1997]

  • Kurtz, Jacqueline R., Robins, Thomas G., and Schork, M. Anthony
  • Journal of Occupational and Environmental Medicine. July 1997, Vol. 39 Issue 7, p661, 11 p.
Subjects
Training, Evaluation, Occupational safety and health -- Training, Employee trainers -- Evaluation, and Occupational health and safety -- Training
Abstract
Social cognitive theory posits that behavior can be changed by observing others perform or describe performance of behaviors. This framework was applied to understanding health behavior change associated with workplace health and safety training. Questionnaires were developed and administered to 426 workers at a United Automobile Worker's Union health and safety training program. Participants received training from one of three trainers: (1) local union discussion leaders (LUDLs), (2) professional staff trainers, or (3) LUDLs with professional staff trainers. Data were collected in three phases: before, after, and three months post-training. Findings show that subjects trained by LUDLs identify most closely with their instructors, whereas subjects trained by staff trainers identify least closely with them. In addition, workers trained by LUDLs reported changing behavior as a result of training more often than workers trained by others.

18. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines [1997]

  • Boshoff, Chris, Endo, Yoshio, Collins, Paul D., Takeuchi, Yasuhiro, Reeves, Jacqueline D., Schweickart, Vicki L., Siani, Michael A., Sasaki, Takuma, Williams, Timothy J., Gray, Patrick W., Moore, Patrick S., Chang, Yuan, and Weiss, Robin A.
  • Science. Oct 10, 1997, Vol. 278 Issue 5336, p290, 5 p.
Subjects
Physiological aspects, Kaposi's sarcoma -- Physiological aspects, HIV, Virus inactivation, HIV infections -- Physiological aspects, HIV (Viruses) -- Inactivation, and HIV infection -- Physiological aspects
Abstract
Kaposi's sarcoma (KS) is a highly angiogenic multicentric tumor most commonly seen in immunodeficient individuals. Since the acquired immunodeficiency syndrome (AIDS) epidemic, KS has become one of the most common [...]
Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus-type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. Like eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I and vMIP-II, but not cellular MIP-1 [Alpha] or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma.

19. Randomised trial of isoniazid versus rifampicin and pyrazinamide for prevention of tuberculosis in HIV-1 infection. [1998]

  • Halsey, Neal A., Coberly, Jacqueline S., Desormeaux, Julio, Atkinson, Joan, Moulton, Lawrence H., Contave, Mireil, Johnson, Michael, Davis, Homer, Geiter, Lawrence, Johnson, Erica, Huebner, Robin, Boulos, Reginald, and Chaisson, Richard E.
  • Lancet. 3/14/1998, Vol. 351 Issue 9105, p786. 7p. 1 Diagram, 5 Charts, 3 Graphs.
Subjects
TUBERCULOSIS prevention, MEDICAL care of HIV-positive persons, ISONIAZID, PTERIDINES, and DRUG efficacy
Abstract
Studies the effectiveness of isoniazid versus rifampicin with pyrazinamide for prevention of tuberculosis in HIV-1 positive individuals. Methods for comparing efficacy of the chemoprophylaxis regimens; Findings; Interpretation. INSET: Disease categories.

20. Latanoprost treatment for glaucoma: effects of treating for 1 year and of switching from timolol [1998]

  • Camras, Carl B., Wax, Martin B., Ritch, Robert, Weinreb, Robert, Robin, Alan L., Higginbotham, Eve J., Lustgarten, Jacqueline, Stewart, William C., Sherwood, Mark, Krupin, Theodore, Wilensky, Jacob, Cioffi, George A., Katz, L. Jay, Schumer, Robert A., Kaufman, Paul L., Minckler, Don, Zimmerman, Thom, and Stjernschantz, Johan
  • American Journal of Ophthalmology. Sept 1998, Vol. 126 Issue 3, p390, 10 p.

21. Anger-related traits and response to interpersonal conflict among New York City traffic agents [1998]

  • Brondolo, Elizabeth, Masheb, Robin, Stores, Jacqueline, Stockhammer, Tanya, Tunick, Wendy, Melhado, Elizabeth, Karlin, William A., Schwartz, Joseph, Harburg, Ernest, and Contrada, Richard J.
  • Journal of Applied Social Psychology. Nov 16, 1998, Vol. 28 Issue 22, p2089, 3 p. 3
Subjects
Anger -- Research, Interpersonal conflict -- Research, Traffic police -- Psychological aspects, and Social psychology -- Research
Abstract
This study evaluates the psychosocial correlates of anger-related traits. Participants include New York City traffic enforcement agents (TEAs), who issue summonses for vehicular and parking violations and are frequently confronted by angry motorists. This sample of TEAs is 53% African American and 57% female. Participants completed surveys at 2 points, 4 months apart, which measured attitudinal, affective, and expressive components of hostility and anger, as well as dimensions of workplace psychosocial response. Results indicate that trait anger-in was positively associated with frequency of conflict, anger intensity, and burnout in cross-sectional analyses; and positively associated with frequency of conflict in prospective analyses. Trait anger was positively associated with an increase in burnout over a 4-month period. These findings provide support for the transactional model of hostility and health and have implications for worksite interventions promoting cardiovascular health.

22. LETTERS. [1999]

  • Brand, William, Rudnick, David, Dunphy, Brendan, Moen, Gerald, Rutelli, Francesco, Fadiman, Jeffrey, Sivasubramanian, M. N., Desmond, Marc, Harris, Robin, Lamont, Lord, Talekar, N. S., Mounteer, Carl, Fitzpatrick, Maurice, Richards, Ian, Teo, Jacqueline, Sass, Edgar, and Dussolier, Maurice
  • Economist. 2/13/1999, Vol. 350 Issue 8106, p6-8. 2p.
Subjects
LETTERS to the editor, DAY trading (Securities), BUBBLE gum, ECONOMICS, and ECONOMIC policy
Abstract
Several letters to the editor are presented in response to articles in previous issues including "When the Bubble Bursts," in the January 30, 1999 issue, "Blame It on the Bubbles," in the January 23, 1999 issue, and "A Nervous Shuffle in Malaysia," in the January 16, 1999 issue.

23. Economic evaluations of community-based care: lessons from twelve studies in Ontario. [1999]

  • Browne, Gina, Roberts, Jacqueline, Gafni, Amiram, Byrne, Carolyn, Weir, Robin, Majumdar, Basanti, and Watt, Susan
  • Journal of Evaluation in Clinical Practice. Dec1999, Vol. 5 Issue 4, p367-385. 19p.
Subjects
COMMUNITY health services, NATIONAL health insurance, and MEDICAL care
Abstract
A series of 12 studies (five historic cohort and seven randomized trials) examined clients in community settings in Southern Ontario suffering from a variety of chronic physical and mental health conditions. These studies are appraised using a framework for evaluating possible outcomes of economic evaluation. In the 12 studies, sample composition and size varied. Each study was designed to quantify the well-being outcomes and expenditures associated with different community-based approaches to care provided in the context of a system of national health insurance. As a collective, these studies represent increasing methodological rigour. Multiple-perspective client well-being outcome measures were used. In two studies, caregiver burden also was analysed. A common approach to quantification and evaluation of expenditures for service consumption was used in all 12 studies. The nature of community-based health services (health vs. disease care orientation) was found to have direct and measurable impact on total expenditures for health service utilization and client well-being outcomes. In most cases, a recurring pattern of equal or better client outcomes, yet lower expenditures for use of community based health services, was associated with well-integrated health oriented services. Integrated services aimed at factors which determine health are superior when compared to individual, fragmented, disease oriented, and focused approaches to care. The main lessons from the 12 studies are that it is as or more effective and as or less expensive to offer complete, proactive, community health services to persons living with chronic circumstance than to provide focused, on-demand, piecemeal services. Complete services would have a psychosocial and mental health focus included with the physical care approach. Furthermore, people with coexisting risk factors (age, living arrangements, mental distress and problem-solving ability) are the ones who most benefit at lower expense... [ABSTRACT FROM AUTHOR]

24. Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis. [1999]

  • Toomes, Carmel, James, Jacqueline, Wood, A. Joseph, Wu, Chu Lee, McCormick, Derek, Lench, Nicholas, Hewitt, Chelsee, Moynihan, Leanne, Roberts, Emma, Woods, C. Geoffrey, Markham, Alexander, Wong, Melanie, Widmer, Richard, Ghaffar, Khaled Abdul, Pemberton, Michael, Hussein, Ibtessam Ramzy, Temtamy, Samia A., Davies, Robin, and Read, Andrew P.
  • Nature Genetics. Dec99, Vol. 23 Issue 4, p421. 4p.
Subjects
PERIODONTAL disease and KERATOSIS
Abstract
Papillon-Lefèvre syndrome, or keratosis palmoplantaris with periodontopathia (PLS, MIM 245000), is an autosomal recessive disorder that is mainly ascertained by dentists because of the severe periodontitis that afflicts patients. Both the deciduous and permanent dentitions are affected, resulting in premature tooth loss. Palmoplantar keratosis, varying from mild psoriasiform scaly skin to overt hyperkeratosis, typically develops within the first three years of life. Keratosis also affects other sites such as elbows and knees. Most PLS patients display both periodontitis and hyperkeratosis. Some patients have only palmoplantar keratosis or periodontitis, and in rare individuals the periodontitis is mild and of late onset. The PLS locus has been mapped to chromosome 11q14-q21 (refs 7-9). Using homozygosity mapping in eight small consanguineous families, we have narrowed the candidate region to a 1.2-cM interval between DllS4082 and D11S931. The gene (CTSC) encoding the lysosomal protease cathepsin C (or dipeptidyl aminopeptidase I) lies within this interval. We defined the genomic structure of CTSC and found mutations in all eight families. In two of these families we used a functional assay to demonstrate an almost total loss of cathepsin C activity in PLS patients and reduced activity in obligate carriers. [ABSTRACT FROM AUTHOR]

25. Cultural sensitivity in substance use prevention. [2000]

  • Resnicow, Ken, Soler, Robin, Braithwaite, Ronald L., Ahluwalia, Jasjit S., and Butler, Jacqueline
  • Journal of Community Psychology. May2000, Vol. 28 Issue 3, p271-290. 20p.
Subjects
SUBSTANCE abuse prevention, ETHNICITY, MEDICAL communication, ETHNIC groups, PATHOLOGICAL psychology, and SOCIAL psychology
Abstract
The rationale for targeted and tailored substance use prevention programs derives from essentially three observations: 1) differences in substance use prevalence rates across racial/ethnic groups; 2) differences in the prevalence of the risk factors for substance use across racial/ethnic groups; and 3) differences in the predictors of substance use across groups. This article provides a model for understanding cultural sensitivity as it pertains to substance use prevention. Cultural sensitivity is defined by two dimensions, surface and deep structure. Surface structure involves matching intervention materials and messages to observable, “superficial” characteristics of a target population. This may involve using people, places, language, product brands, music, food, locations, and clothing familiar to, and preferred by, the target audience. Surface structure refers to how well interventions fit within a specific culture. Deep structure involves incorporating the cultural, social, historical, environmental, and psychologic forces that influence the target health behavior in the proposed target population. For example, peer influences may exert a greater influence on substance use initiation among White and Hispanic than among African American youth, while parental influences may be stronger among African Americans. Whereas surface structure generally increases the "receptivity" or "acceptance" of messages, deep structure conveys salience. Techniques for developing culturally sensitive interventions, borrowed from social marketing and health communication theory, are described. © 2000 John Wiley & Sons, Inc. [ABSTRACT FROM AUTHOR]

26. Reviews. [2001]

  • Young, Robin Darling, Marina, Jacqueline, Rae, Murray, Wainwright, Geoffrey, Lipton, Diana, Griffiths, Paul J., Collinge, William J., Fowl, Stephen, Valliere, Paul, and Tanner, Kathryn
  • Modern Theology. Jul2001, Vol. 17 Issue 3.
Subjects
DYING for God (Book), KANT the Problem of God (Book), and SUFFERING Divine Things (Book)
Abstract
Books reviewed: Daniel Boyarin Dying for God: Martyrdom and the Making of Christianity and Judaism . Gordon E. Michalson, Jr. Kant and the Problem of God . Reinhard Hütter Suffering Divine Things: Theology as Church Practice . Boris Bobrinskoy The Mystery of the Trinity: Trinitarian Experience and Vision in the Biblical and Patristic Tradition . Tod Linafelt Surviving Lamentations: Catastrophe, Lament and Protest in the Afterlife of a Biblical Book . F. Samuel Brainard Reality and Mystical Experience . Sandra Lee Dixon Augustine: The Scattered and Gathered Self . Elisabeth Schüssler Fiorenza Rhetoric and Ethic: The Politics of Biblical Studies . Vladimir Wozniuk (Ed.) Politics, Law, and Morality: Essays by V. S. Soloviev . Rowan Williams Lost Icons: Reflections on Cultural Bereavement [ABSTRACT FROM AUTHOR]

27. Association of Polymorphisms in the Apolipoprotein E Region with Susceptibility to and Progression of Multiple Sclerosis. [2002]

  • Schmidt, Silke, Barcellos, Lisa F., DeSombre, Karen, Rimmler, Jacqueline B., Lincoln, Robin R., Bucher, Patricia, Saunders, Ann M., Lai, Eric, Martin, Eden R., Vance, Jeffery M., Oksenberg, Jorge R., Hauser, Stephen L., Pericak-Vance, Margaret A., and Haines, Jonathan L.
  • American Journal of Human Genetics. Mar2002, Vol. 70 Issue 3, p708. 10p.
Subjects
GENETICS of multiple sclerosis, APOLIPOPROTEIN E, GENETIC polymorphisms, and GENETICS of disease susceptibility
Abstract
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. The contribution of the major histocompatibility complex (MHC) has been established in numerous genetic linkage and association studies. In addition to the MHC, the chromosome 19q13 region surrounding the apolipoprotein E (APOE) gene has shown consistent evidence of involvement in MS when family-based analyses were conducted. Furthermore, several clinical reports have suggested that the APOE-4 allele may be associated with more-severe disease and faster progression of disability. To thoroughly examine the role of APOE in MS, we genotyped its functional alleles, as well as seven single-nucleotide polymorphisms (SNPs) located primarily within 13 kb of APOE, in a data set of 398 families. Using family-based association analysis, we found statistically significant evidence that an SNP haplotype near APOE is associated with MS susceptibility (P = .005 ). An analysis of disease progression in 614 patients with MS from 379 families indicated that APOE-4 carriers are more likely to be affected with severe disease (P = .03 ), whereas a higher proportion of APOE-2 carriers exhibit a mild disease course (P = .02 ). [ABSTRACT FROM AUTHOR]

28. Myogenic reactivity is reduced in small renal arteries isolate from relaxin-treated rats. [2002]

  • Novak, Jacqueline, Ramirez, Rolando J.J., Gandley, Robin E., Sherwood, O. David, and Conrad, Kirk P.
  • American Journal of Physiology: Regulatory, Integrative & Comparative Physiology. Aug2002, Vol. 52 Issue 2, pR349. 7p. 5 Graphs.
Subjects
RELAXIN, RAT physiology, RENAL artery, MYOGENESIS, and MESENTERIC artery
Abstract
Presents information on a study which investigated whether myogenic reactivity of small renal and mesenteric arteries is reduced in relaxin-treated rats. Methodology; Impact of relaxin on myogenic reactivity; Link between denudation of endothelium and myogenic reactivity; Role of nitric oxide in the reduction of myogenic activity.

29. Reactivity of carbanions of Fischer-type carbene complexes with pyrylium salts. Synthesis and characterization of new γ-methylenepyran carbene complexes via an addition–oxidation–deprotonation process [2002]

  • Caro, Bertrand, Le Poul, Pascal, Robin-Le Guen, Françoise, Saillard, Jean-Yves, Kahlal, Samia, Moinet, Claude, Le Poul, Nicolas, and Vaissermann, Jacqueline
  • Tetrahedron. Sep2002, Vol. 58 Issue 37, p7519. 12p.
Subjects
CONDENSATION, PYRYLIUM compounds, and CARBANIONS
Abstract
The condensation reaction between γ-unsubstituted pyrylium salts and carbanions of Fischer-type carbene complexes allowed the synthesis of new γ-methylenepyran carbene complexes. NMR data, single crystal X-ray analysis, and DFT calculations suggest that these complexes have a partial pyrylium character due to the π electron-accepting ability of the carbenic fragment and to the electron-releasing properties of the methylenepyran part. [Copyright &y& Elsevier]

30. Letters. [2002]

  • Atkinson, Jacqueline M, Wells, Frank O, Oliver, James, Webb, David J, Patole, Sanjay, Travadi, Javeed, von Kaehne, Peter, Jones, Graham A, Mathy, Robin M, Rushton, D Hugh, Dover, Robin, Sainsbury, Anthony W, Norris, Michael J, Gilkes, Jeremy J H, Ramsay, Ian D, Navein, John F, Simey, Piers W, Skelton, Dawn, and Dinan, Susie
  • BMJ: British Medical Journal (International Edition). 11/16/2002, Vol. 325 Issue 7373, p1174. 4p. 1 Chart, 1 Graph.
Subjects
LETTERS to the editor, MEDICAL personnel, CLINICAL medicine, and PHYSICIANS' correspondence
Abstract
Presents letters to the editor and correspondence between medical practitioners as of November 16, 2002. Undisclosed payments in research; Use of sildenafil for so-called blue babies; Making the best of health advocates and interpreters; Homosexual-related legislation and suicidal intent among sexual minority groups; Iron deficiency in women's health; Others.

31. Efficient production of Arthromyces ramosus peroxidase by Aspergillus awamori [2003]

  • Lokman, B. Christien, Joosten, Vivi, Hovenkamp, Jacqueline, Gouka, Robin J., Verrips, C. Theo, and van den Hondel, Cees A.M.J.J.
  • Journal of Biotechnology. Jun2003, Vol. 103 Issue 2, p183. 8p.
Subjects
XYLANASES and ASPERGILLUS
Abstract
The heterologous production of Arthromyces ramosus peroxidase (ARP) was analysed in the filamentous fungus Aspergillus awamori under control of the inducible endoxylanase promoter. Secretion of active ARP was achieved up to 800 mg l−1 in shake flask cultures. Western blot analysis showed that an rARP product of the correct molecular weight was produced. In contrast to several other studies about heterologous production of heme containing peroxidases, our results suggest that in A. awamori no heme limitation exists during overproduction of ARP. [Copyright &y& Elsevier]

32. Butyrate-treated colonic Caco-2 cells exhibit defective integrin-mediated signaling together with increased apoptosis and differentiation. [2003]

  • Peggy Lévy, Hélène Robin, France Bertrand, Michel Kornprobst, and Jacqueline Capeau
  • Journal of Cellular Physiology. Dec2003, Vol. 197 Issue 3, p336. 12p.
Subjects
CELL differentiation, APOPTOSIS, FATTY acids, and PROTEINS
Abstract
We previously reported that the enterocytic differentiation of human colonic Caco-2 cells correlated with alterations in integrin signaling. We now investigated whether differentiation and apoptosis of Caco-2 cells induced by the short-chain fatty acid butyrate (NaBT) was associated with alterations in the integrin-mediated signaling pathway with special interest in the expression and activity of focal adhesion kinase (FAK), of the downstream phosphatidylinositol 3'-kinase (PI 3-kinase)Akt pathway and in the role of the nuclear factor κB (NF-κB). NaBT increased the level of sucrase. It induced apoptosis as shown by: (1) decreased Bcl-2 and Bcl-XL proteins and increased Bax protein; (2) activation of caspase-3; and (3) increased shedding of apoptotic cells in the medium. This effect was associated with defective integrin-mediated signaling as shown by: (1) down-regulation of β1 integrin expression; 2) decreased FAK expression and tyrosine phosphorylation; (3) concerted alterations in cytoskeletal and structural focal adhesions proteins (talin, ezrin); and (4) decreased FAK ability to associate with PI 3-kinase. However, in Caco-2 cells, β1-mediated signaling failed to be activated downstream of FAK and PI 3-kinase at the level of Akt. Transfection studies show that NaBT treatment of Caco-2 cells promoted a significant activation of the NF-κB which was probably involved in the NaBT-induced apoptosis. Our results indicate that the prodifferentiating agent NaBT induced apoptosis of Caco-2 cells probably through NF-κB activation together with a defective β1 integrin-FAK-PI 3-kinase pathways signaling. J. Cell. Physiol. 197: 336347, 2003© 2003 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

33. Firing Patterns of Type II Spiral Ganglion Neurons In Vitro. [2004]

  • Reid, Michael A., Flores-Otero, Jacqueline, and Davis, Robin L.
  • Journal of Neuroscience. 1/21/2004, Vol. 24 Issue 3, p733-742. 10p. 4 Color Photographs, 1 Black and White Photograph, 5 Graphs.
Subjects
NEURONS, ELECTROPHYSIOLOGY, SENSORY receptors, HAIR cells, and COCHLEA
Abstract
Type I and type II spiral ganglion neurons convey auditory information from the sensory receptors in the cochlea to the CNS. The numerous type I neurons have been extensively characterized, but the small population of type II neurons with their unmyelinated axons are undetectable with most recording methods. Despite the paucity of information about the type II neurons, it is clear that they must have a significant role in sound processing because they innervate the large number of outer hair cells that are critical for maintaining normal responses to stimuli. To elucidate the function of type II neurons, we have developed an approach for studying their electrophysiological features in vitro. Type II neurons obtained from postnatal day 6-7 mice displayed distinctly different firing properties than type I neurons. They showed slower accommodation, lower action potential thresholds, and more prolonged responses to depolarizing current injection than the type I neurons. These differences were most evident in neurons from the basal, high-frequency region of the cochlea. The basal type I neurons displayed uniformly fast firing features, whereas the basal type II neurons showed particularly slow accommodation and responses to depolarization. Interestingly, neurons from the apical, low-frequency region of the cochlea showed the opposite trend. These data suggest that the type I and type II neurons have specialized electrophysiological characteristics tailored to their different roles in auditory signal processing. In particular, the type II neuron properties are consistent with cells in other sensory systems that receive convergent synaptic input for high-sensitivity stimulus detection. [ABSTRACT FROM AUTHOR]

34. Removing GPS collar bias in habitat selection studies. [2004]

  • Frair, Jacqueline L., Nielsen, Scott E., Merrill, Evelyn H., Lele, Subhash R., Boyce, Mark S., Munro, Robin H. M., Stenhouse, Gordon B., and Beyer, Hawthorne L.
  • Journal of Applied Ecology. Apr2004, Vol. 41 Issue 2, p201-212. 12p.
Subjects
HABITAT selection, GLOBAL Positioning System, HABITATS, VEGETATION & climate, RADIO telemetry, and ANIMAL radio tracking
Abstract
Journal of Applied Ecology (2004) 41, 201–212 [ABSTRACT FROM AUTHOR]

35. Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35 [2004]

  • Marazita, Mary L., Murray, Jeffrey C., Lidral, Andrew C., Arcos-Burgos, Mauricio, Cooper, Margaret E., Goldstein, Toby, Maher, Brion S., Daack-Hirsch, Sandra, Schultz, Rebecca, Mansilla, M. Adela, Field, L. Leigh, Liu, You-e, Prescott, Natalie, Malcolm, Sue, Winter, Robin, Ray, Ajit, Moreno, Lina, Valencia, Consuelo, Neiswanger, Katherine, Wyszynski, Diego F., Bailey-Wilson, Joan E., Albacha-Hejazi, Hasan, Beaty, Terri H., McIntosh, Iain, Hetmanski, Jacqueline B., Tuncbilek, Gokhan, Edwards, Matthew, Harkin, Louise, Scott, Rodney, and Roddick, Laurence G.
  • American Journal of Human Genetics. August 2004, Vol. 75 Issue 2, p161, 13 p.
Subjects
Research, Analysis, Cleft lip -- Research, Cleft lip -- Analysis, Cleft palate -- Research, Cleft palate -- Analysis, and Genetic research

36. Positive end-expiratory pressure above lower inflection point minimizes influx of activated neutrophils into lung. [2004]

  • Monkman, Shelley L, Andersen, Chad C, Nahmias, Claude, Ghaffer, Hasan, Bourgeois, Jacqueline M, Roberts, Robin S, Schmidt, Barbara, and Kirpalani, Haresh M
  • Critical Care Medicine. Dec2004, Vol. 32 Issue 12, p2471-2475. 5p.
Abstract
Objectives: To compare the effects of low vs. high tidal volume (Vt) with three positive end-expiratory pressure (PEEP) strategies on activated neutrophil influx into the lung.Design: Prospective, randomized controlled animal study.Setting: Animal laboratory in a university hospital.Subjects: Newborn piglets.Interventions: Surfactant-depleted piglets were randomized in littermate pairs; to PEEP of either 0 (zero end-expiratory pressure [ZEEP]; n = 6), 8 cm H2O (PEEP 8; n = 5), or 1 cm H2O above the lower inflection point (LIP) (PEEP>LIP; n = 6). Within each pair piglets were randomized to a low VT (5-7 mL/kg) or high VT strategy (17-19 mL/kg). After 4 hrs of mechanical ventilation, 18-fluorodeoxyglucose (18FDG) was injected and positron emission tomography scanning was performed.Measurements and Main Results: VT and PEEP changes on influx constants of 18FDG were assessed by analysis of variance. A within-litter comparison of Vt was nonsignificant (p = .50). A between-litter comparison, ordered in linear trend rank, from ZEEP, to PEEP 8, to PEEP>LIP, showed a strong effect of PEEP on influx constant (p = .019).Conclusions: PEEP set above the LIP on the inspiratory limb of the pressure-volume curve affords a stronger lung protection than VT strategy. [ABSTRACT FROM AUTHOR]

37. THE PREVALENCE, CORRELATES, AND COSTS OF DEPRESSION IN PEOPLE LIVING WITH HIV/AIDS IN ONTARIO: IMPLICATIONS FOR SERVICE DIRECTIONS. [2005]

  • Williams, Peter, Narciso, Lea, Browne, Gina, Roberts, Jacqueline, Weir, Robin, and Gafni, Amiram
  • AIDS Education & Prevention. Apr2005, Vol. 17 Issue 2, p119-130. 12p. 6 Charts.
Subjects
MENTAL depression, QUALITY of life, PSYCHOLOGICAL adaptation, HIV-positive persons, AIDS patients, and SOCIAL services
Abstract
Examines the prevalence of depression, and its association with quality–of–life, coping strategies, social support, and use of health and social services among people living with HIV and AIDS in Ontario. Indication of the prevalence of depression; Increase of the use of crisis health care and related services among subjects; Improvement of the quality of life through expanding the capacity of medical workers to recognize and address depression.

38. Standards for hospital libraries 2002 with 2004 revisions. [2005]

  • Hassig, Robin Ackley, Balogh, Leeni, Bandy, Margaret, Doyle, Jacqueline Donaldson, Gluck, Jeannine Cyr, Lindner, Katherine Lois, Reich, Barbara, and Varner, Douglas
  • Journal of the Medical Library Association. Apr2005, Vol. 93 Issue 2, p282-283. 2p.
Subjects
BOOKS, LIBRARIES, INFORMATION science, HEALTH services administration, HEALTH of physicians, and MEDICAL care
Abstract
The article presents a special report on the book "Standards for Hospital Libraries 2002." The 2004 revisions of the book include an expansion of standard 6, which is a glossary definition of "library," and updates to the bibliography. The expanded standard 6 defines appropriate resources, technology, and services that must be provided. The updates to the bibliography include the latest edition of the Joint Commission on Accreditation of Healthcare Organizations Comprehensive Accreditation Manual for Hospitals, the Medical Library Association policy statement on the role of expert searching in health sciences libraries, and updates of some Website addresses. The librarian uses a variety of tools and techniques, both formal and informal, to assess the knowledge-based information needs of the hospital and medical staff. The needs assessment should address the timeliness of information services and document delivery. In response, resources and services are made available to meet those identified needs.

39. Over- and Underdosage of SOX3 Is Associated with Infundibular Hypoplasia and Hypopituitarism. [2005]

  • Woods, Kathryn S., Gundall, Maria, Turton, James, Rizotti, Karine, Mehta, Ameeta, Palmer, Rodger, Jacqueline Wong, Chong, W. K., Al-Zyoud, Mahmoud, El-Ali, Maryam, Otonkoski, Timo, Martinez-Barbera, Juan-Pedro, Thomas, Paul Q., Robinson, Iain C., Lovell-Badge, Robin, Woodward, Karen J., and Dattani, Mehut T.
  • American Journal of Human Genetics. May2005, Vol. 76 Issue 5, p833-849. 17p.
Subjects
SHEEHAN'S syndrome, SOMATOTROPIN, INTELLECTUAL disabilities, ETIOLOGY of diseases, TRANSCRIPTION factors, and PATHOLOGICAL psychology
Abstract
Duplications of Xq26-27 have been implicated in the etiology of X-linked hypopituitarism associated with mental retardation (MR). Additionally, an expansion of a polyalanine tract (by 11 alanines) within the transcription factor SOX3 (Xq27.1) has been reported in patients with growth hormone deficiency and variable learning difficulties. We report a submicroscopic duplication of Xq27.1, the smallest reported to date (685.6 kb), in two siblings with variable hypopituitarism, callosal abnormalities, anterior pituitary hypoplasia (APH), an ectopic posterior pituitary (EPP), and an absent infundibulum. This duplication contains SOX3 and sequences corresponding to two transcripts of unknown function; only Sox3 is expressed in the infundibulum in mice. Next, we identified a novel seven-alanine expansion within a polyalanine tract in SOX3 in a family with panhypopituitarism in three male siblings with an absent infundibulum, severe APH, and EPP. This mutation led to reduced transcriptional activity, with impaired nuclear localization of the mutant protein. We also identified a novel polymorphism (A43T) in SOX3 in another child with hypopituitarism. In contrast to findings in previous studies, there was no evidence of MR or learning difficulties in our patients. We conclude that both over- and underdosage of SOX3 are associated with similar phenotypes, consisting of infundibular hypoplasia and hypopituitarism but not necessarily MR. [ABSTRACT FROM AUTHOR]

40. Characteristics of people living with HIV who use community-based services in Ontario, Canada: Implications for service providers [2005]

  • Williams, Peter, Narciso, Lea, Browne, Gina, Roberts, Jacqueline, Weir, Robin, and Gafni, Amiram
  • Journal of the Association of Nurses in AIDS Care. July-August 2005, Vol. 16 Issue 4, p50, 14 p.
Subjects
Diagnosis, Health aspects, Surveys, HIV infections -- Diagnosis, HIV patients -- Health aspects, HIV patients -- Surveys, and HIV infection -- Diagnosis
Abstract
A study of people living with Acquired Immune Deficiency Syndrome (AIDS) in Ontario, Canada examines the demographic and health-related characteristics of people with AIDS who do and do not use community-based AIDS service organizations (CBAOs) and their patterns of mainstream service utilization. Results indicate that CBAOs are being accessed appropriately by those who were most vulnerable.

41. A high-density screen for linkage in multiple sclerosis: international multiple sclerosis genetics consortium * [2005]

  • Sawcer, Stephen, Ban, Maria, Maranian, Mel, Yeo, Tai Wai, Compston, Alastair, Kirby, Andrew, Daly, Mark J., De Jager, Philip L., Walsh, Emily, Lander, Eric S., Rioux, John D., Hafler, David A., Ivinson, Adrian, Rimmler, Jacqueline A., Gregory, Simon, Schmidt, Silke, Pericak-Vance, Margaret A., Akesson, Eva, Hillert, Jan, Datta, Pameli, Oturai, Annette, Ryder, Lars P., Harbo, Hanne F., Spurkland, Anne, Myhr, Kjell-Morten, Laaksonen, Mikko, Booth, David, Heard, Robert, Stewart, Graeme, Lincoln, Robin, Barcellos, Lisa F., Hauser, Stephen L., Oksenberg, Jorge R., Kenealy, Shannon J., and Haines, Jonathan L.
  • American Journal of Human Genetics. Sept 2005, Vol. 77 Issue 3, p454, 14 p.
Subjects
Research, Genetic aspects, Human genetics -- Research, and Multiple sclerosis -- Genetic aspects

42. Positive and negative symptoms in affected sib pairs with schizophrenia: Implications for genetic studies in an African Xhosa sample [2005]

  • Niehaus, Dana J.H., Koen, Liezl, Laurent, Claudine, Muller, Jacqueline, Deleuze, Jean-Francois, Mallet, Jacques, Seller, Cathlene, Jordaan, Esme, and Emsley, Robin
  • Schizophrenia Research. Nov2005, Vol. 79 Issue 2/3, p239-249. 11p.
Subjects
SCHIZOPHRENIA, PSYCHOSES, DELUSIONS, HALLUCINATIONS, DIAGNOSIS of schizophrenia, SIBLINGS, CHI-squared test, COMPARATIVE studies, DEMOGRAPHY, FACTOR analysis, FAMILY health, RESEARCH methodology, MEDICAL cooperation, PSYCHOLOGICAL tests, PSYCHOLOGY, RESEARCH, EVALUATION research, and SEVERITY of illness index
Abstract
Abstract: Careful phenotyping and the identification of subtypes of schizophrenia can contribute significantly to the success of genetic studies in schizophrenia. The phenomenology of schizophrenia in affected sib pairs has been well-described in Caucasian populations, however a paucity of data exists for African populations. This study therefore investigated symptom dimensions in a sizeable group of affected Xhosa sib pairs as a means of evaluating the role of shared familial factors in the psychosis of schizophrenia. Five hundred and thirteen participants were interviewed with the Diagnostic Interview for Genetic Studies (DIGS), which included the Schedules for the Assessment of Negative and Positive symptoms (SANS/SAPS). One hundred and four sib pairs were then extracted (N =208) for analysis of concordance for lifetime psychotic symptoms and an exploratory factor analysis of the SANS/SAPS. Concordance analysis of life-time symptoms indicated a significant concordance for olfactory hallucinations, persecutory delusions, jealousy, somatic, reference and control delusions as well as thought insertion and withdrawal. The factor analysis of the global scores of the SAPS and SANS revealed a five factor best-fit model and accounted for 92.5% of variance. The factors included a negative symptom factor, a positive symptom factor, a positive thought disorder and a bizarre behaviour component. The core symptomatology of schizophrenia in this sib pair sample was similar to that reported in Caucasian populations with the exception of higher rates of auditory hallucinations and delusions of persecution. In summary therefore; although the factor analysis only supported the concept of the universality of psychotic symptoms in schizophrenia, the concordance analysis of these symptoms did reveal hallucinations as well as delusions of control as possible candidates relevant for future research into genotype–phenotype relationships. [Copyright &y& Elsevier]

43. Tricyclic azepine derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors [2006]

  • Smith, Leon, Piatnitski, Evgueni L., Kiselyov, Alexander S., Ouyang, Xiaohu, Chen, Xiaoling, Burdzovic-Wizemann, Sabina, Xu, Yongjiang, Wang, Ying, Rosler, Robin L., Patel, Sheetal N., Chiang, Hui-Hsien, Milligan, Daniel L., Columbus, John, Wong, Wai C., Doody, Jacqueline F., and Hadari, Yaron R.
  • Bioorganic & Medicinal Chemistry Letters. Mar2006, Vol. 16 Issue 6, p1643-1646. 4p.
Subjects
AZEPINES, HETEROCYCLIC compounds, EPIDERMAL growth factor, and PROTEIN-tyrosine kinase inhibitors
Abstract
Abstract: A novel class of pyrimido[4,5-b]-1,4-benzoxazepines is described as inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase. Two compounds display potent EGFR inhibitory activity of less than 1μM in cellular phosphorylation assays (IC50 0.47–0.69μM) and are highly selective against a small kinase panel. Such compounds demonstrate anti-EGFR activity within a class that is different from any known EGFR inhibitor scaffolds. They also provide a basis for the design of kinase inhibitors with the desired selectivity profile. [Copyright &y& Elsevier]

44. Health consequences of the September 11 World Trade Center attacks: a review. [2006]

  • Moline, Jacqueline, Herbert, Robin, and Nguyen, Ngoctram
  • Cancer Investigation. 2006, Vol. 24 Issue 3, p294-301. 8p.
Subjects
SEPTEMBER 11 Terrorist Attacks, 2001, PARTICLES, TOXINS, GLASS fibers, POLYCYCLIC aromatic hydrocarbons, DIOXINS, and PUBLIC health
Abstract
In the aftermath of the September 11 World Trade Center (WTC) attack, a large number of people sustained potential exposures to smoke, dust, particulate matter, and a variety of toxins, including asbestos, pulverized concrete, glass fibers, polycyclic aromatic hydrocarbons (PAHs), and polychlorinated furans and dioxins. Additionally, many had exposure to psychological traumatogens. The most common effects seen to date are respiratory and mental health consequences. The long-term consequences of exposures are not yet known, and there remains concern about the potential for late-emerging diseases such as cancers. This article reviews WTC-related health effects, the spectrum of exposures and how they were documented, and discusses future preventive efforts. [ABSTRACT FROM AUTHOR]

45. Corrigendum to “Tricyclic azepine derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors” [Bioorg. Med. Chem. Lett. 16 (2006) 1643–1646] [2006]

  • Smith, Leon, Piatnitski, Evgueni L., Kiselyov, Alexander S., Ouyang, Xiaohu, Chen, Xiaoling, Burdzovic-Wizemann, Sabina, Xu, Yongjiang, Pan, Weitao, Chen, Xin, Wang, Ying, Rosler, Robin L., Patel, Sheetal N., Chiang, Hui-Hsien, Milligan, Daniel L., Columbus, John, Wong, Wai C., Doody, Jacqueline F., and Hadari, Yaron R.
  • Bioorganic & Medicinal Chemistry Letters. Jul2006, Vol. 16 Issue 14, p3869-3869. 1p.

46. Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase [2006]

  • Smith, Leon, Wong, Wai C., Kiselyov, Alexander S., Burdzovic-Wizemann, Sabina, Mao, Yunyu, Xu, Yongjiang, Duncton, Matthew A.J., Kim, Ki, Piatnitski, Evgueni L., Doody, Jacqueline F., Wang, Ying, Rosler, Robin L., Milligan, Daniel, Columbus, John, Balagtas, Chris, Lee, Sui Ping, Konovalov, Andrey, and Hadari, Yaron R.
  • Bioorganic & Medicinal Chemistry Letters. Oct2006, Vol. 16 Issue 19, p5102-5106. 5p.
Subjects
DIAZEPINES, EPIDERMAL growth factor, CYTOKINES, and PROTEIN-tyrosine kinases
Abstract
Abstract: Novel tricyclic derivatives containing an oxazepine, thiazepine, or diazepine ring were studied for their EGFR tyrosine kinase inhibitory activity. While the oxazepines were in general more potent than thiazepines, the diazepines displayed somewhat different structure–activity relationships. Moreover, the diazepines, in contrast to the oxazepines, showed appreciable inhibitory activity against the KDR tyrosine kinase. Furthermore, both oxazepines and diazepines demonstrated significant ability to inhibit autophosphorylation of EGFR in DiFi cells (generally, IC50 values in the single-digit micromolar to submicromolar range). [Copyright &y& Elsevier]

47. The Effectiveness and Efficiency of Home-Based Nursing Health Promotion for Older People: A Review of the Literature. [2006]

  • Markle-Reid, Maureen, Browne, Gina, Weir, Robin, Gafni, Amiram, Roberts, Jacqueline, and Henderson, Sandra R.
  • Medical Care Research & Review. Oct2006, Vol. 63 Issue 5, p531-569. 39p. 2 Diagrams, 3 Charts.
Subjects
COMMUNITY health nurses, HEALTH promotion, HOME care of older people, HOME care services, and COMMUNITY health services
Abstract
Despite the large potential role that community nurses have in providing individualized health promotion to older people, there is a lack of consensus in the literature regarding this role's effectiveness and efficiency. This article presents a literature review and synthesis of 12 randomized controlled trials selected from 344 published studies on preventive home visitation programs for older people. The findings suggest that a diversity of home visiting interventions carried out by nurses can favorably affect health and functional status, mortality rates, use of hospitalization and nursing homes, and costs. Further research is needed that focuses on the outcomes of quality of life, mental health, social support, caregiver burden, the acceptability of intervention, and specific subgroups of clients who benefit most. Findings also indicate the need for a theoretical foundation, increased emphasis on health-promotion strategies, and more research using a more complete economic evaluation to establish efficiency. [ABSTRACT FROM AUTHOR]

48. The world trade center disaster and the health of workers: five-year assessment of a unique medical screening program [2006]

  • Herbert, Robin, Moline, Jacqueline, Skloot, Gwen, Metzger, Kristina, Baron, Sherry, Luft, Benjamin, Markowitz, Steven, Udasin, Iris, Harrison, Denise, Stein, Diane, Todd, Andrew, Enright, Paul, Stellman, Jeanne Mager, Landrigan, Philip J., and Levin, Stephen M.
  • Environmental Health Perspectives. December, 2006, Vol. 114 Issue 12, p1853, 6 p.
Subjects
Mental health, Medical screening, Construction workers, Environmental issues, and Health
Abstract
BACKGROUND: Approximately 40,000 rescue and recovery workers were exposed to caustic dust and toxic pollutants following the 11 September 2001 attacks on the World Trade Center (WTC). These workers included [...]

49. WTC five-year assessment: Herbert et al. respond [2007]

  • Herbert, Robin, Skloot, Gwen, Metzger, Kristina, Landrigan, Philip J., Moline, Jacqueline, Stein, Diane, Todd, Andrew, Levin, Stephen M., Baron, Sherry, and Udasin, Iris
  • Environmental Health Perspectives. Feb 2007, Vol. 115 Issue 2, pA72, 2 p.
Abstract
In our article (Herbert et al. 2006), we described the establishment of the World Trade Center (WTC) Worker and Volunteer Medical Screening Program and presented results of screening examinations undertaken [...]

50. Letters. [2007]

  • Fisher, Trevor, Karp, Jacqueline, Addington, Jim, Arrand, Peter, Cowley, George, Green, Colin, Hamel, Noel, Clark, Roy, Wendt, Robin, Sturgeon, Nicola, Reed, Jamie, Burns-Cox, Chris, and McKenna, Peter
  • New Statesman. 5/21/2007, Vol. 136 Issue 4845, p6-7. 2p. 1 Illustration.
Subjects
LETTERS to the editor
Abstract
Several letters to the editor are presented in response to articles in previous issues including an editorial, a column by John Pilger concerning Robert F. Kennedy and Gordon Brown and the article "Inside Track" by Philip Gould. All of these items appeared in the May 14, 2007 issue.

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