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1. d-Amino acids: new clinical pathways for brain diseases. [2023]

  • Souza INO, Roychaudhuri R, de Belleroche J, and Mothet JP
  • Trends in molecular medicine [Trends Mol Med] 2023 Dec; Vol. 29 (12), pp. 1014-1028. Date of Electronic Publication: 2023 Sep 26.
Subjects
Humans, Critical Pathways, Central Nervous System metabolism, Brain metabolism, Amino Acids metabolism, and Alzheimer Disease metabolism
Abstract
Free d-amino acids (d-AAs) are emerging as a novel and important class of signaling molecules in many organs, including the brain and endocrine systems. There has been considerable progress in our understanding of the fundamental roles of these atypical messengers, with increasingly recognized implications in a wide range of neuropathologies, including schizophrenia (SCZ), epilepsy, Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), substance abuse, and chronic pain, among others. Research has enabled the discovery that d-serine, d-aspartate and more recently d-cysteine are essential for the healthy development and function of the central nervous system (CNS). We discuss recent progress that has profoundly transformed our vision of numerous physiological processes but has also shown how d-AAs are now offering therapeutic promise in clinical settings for several human diseases.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)

2. Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial [2023]

  • Daix, Thomas, Mathonnet, Armelle, Brakenridge, Scott, Dequin, Pierre-François, Mira, Jean-Paul, Berbille, Frederique, Morre, Michel, Jeannet, Robin, Blood, Teresa, Unsinger, Jacqueline, Blood, Jane, Walton, Andrew, Moldawer, Lyle L., Hotchkiss, Richard, and Francois, Bruno
  • Annals of Intensive Care. December, 2023, Vol. 13 Issue 1

3. Earthquake early warning in Central America: The societal perspective. [2023]

  • Orihuela, Benazir, Dallo, Irina, Clinton, John, Strauch, Wilfried, Protti, Marino, Yani, Robin, Marroquín, Griselda, Sanchez, Jacqueline, Vega, Floribeth, Marti, Michèle, Massin, Frédérick, Böse, Maren, and Wiemer, Stefan
  • International Journal of Disaster Risk Reduction; Oct2023, Vol. 97, pN.PAG-N.PAG, 1p
Abstract
Central America has an elevated seismic risk, resulting from the vulnerability of the building stock and steady population growth. Earthquake Early Warning (EEW) aims to provide warning in advance of imminent shaking, allowing recipients to take action and reduce casualties during damaging motions. The Swiss Seismological Service (SED) has been collaborating with local seismic agencies to develop national EEW systems across Central America, which can potentially benefit nearly 47 million inhabitants. We conducted a public survey to comprehend the desire for EEW, the preferences for EEW attributes, and the current behaviour of people during earthquakes and the driving factors behind it. We recruited participants from Nicaragua (N = 513), Costa Rica (N = 1350), Guatemala (N = 559), and El Salvador (N = 491). In all four countries, participants consider it necessary to have an EEW system, are tolerant of false alerts, and are likely to react promptly to alerts. The desirable alert threshold is for low felt intensities, ranging between MMI III to IV. We found that a significant number of respondents already take protective action when earthquakes strike, and appropriate reactions are expected to increase when EEW is available. Our survey is unique in providing insights into the social dimension of EEW systems in low-income regions with high earthquake risk and where no operational EEW system yet exists. • A public survey conducted in Central America reveals strong enthusiasm for Earthquake Early Warning (EEW). The findings indicate that the public is tolerant to false alerts and is likely to react promptly to alerts. • The public reports experiencing significant and damaging shaking, consistent with strong events occurring in living memory. The survey shows the elevated seismic hazard and seismic vulnerability in Central America. • Recommended protective actions are already being practised across Central America and can be expected to increase when EEW becomes available. • Participants exhibit general awareness of the threat posed by earthquakes, for example through previous experience of damaging shaking, participations in preparedness planning and being aware of living in vulnerable housing. These examples influence whether people take protective actions and their opinion of EEW, including its perceived benefit, acceptable warning times, and tolerance for false, late and missed alerts. [ABSTRACT FROM AUTHOR]

4. Invasive Endotyping in Patients With Angina and No Obstructive Coronary Artery Disease: A Randomized Controlled Trial. [2023]

  • Sidik NP, Stanley B, Sykes R, Morrow AJ, Bradley CP, McDermott M, Ford TJ, Roditi G, Hargreaves A, Stobo D, Adams J, Byrne J, Mahrous A, Young R, Carrick D, McGeoch R, Corcoran D, Lang NN, Heggie R, Wu O, McEntegart MB, McConnachie A, and Berry C
  • Circulation [Circulation] 2023 Oct 05. Date of Electronic Publication: 2023 Oct 05.
Abstract
Background: We investigated the usefulness of invasive coronary function testing to diagnose the cause of angina in patients with no obstructive coronary arteries.
Methods: Outpatients referred for coronary computed tomography angiography in 3 hospitals in the United Kingdom were prospectively screened. After coronary computed tomography angiography, patients with unobstructed coronary arteries, and who consented, underwent invasive endotyping. The diagnostic assessments included coronary angiography, fractional flow reserve (patient excluded if ≤0.80), and, for those without obstructive coronary artery disease, coronary flow reserve (abnormal <2.0), index of microvascular resistance (abnormal ≥25), and intracoronary infusion of acetylcholine (0.182, 1.82, and 18.2 μg/mL; 2 mL/min for 2 minutes) to assess for microvascular and coronary spasm. Participants were randomly assigned to disclosure of the results of the coronary function tests to the invasive cardiologist (intervention group) or nondisclosure (control group, blinded). In the control group, a diagnosis of vasomotor angina was based on medical history, noninvasive tests, and coronary angiography. The primary outcome was the between-group difference in the reclassification rate of the initial diagnosis on the basis of coronary computed tomography angiography versus the final diagnosis after invasive endotyping. The Seattle Angina Questionnaire summary score and Treatment Satisfaction Questionnaire for Medication were secondary outcomes.
Results: Of 322 eligible patients, 250 (77.6%) underwent invasive endotyping; 19 (7.6%) had obstructive coronary disease, 127 (55.0%) had microvascular angina, 27 (11.7%) had vasospastic angina, 17 (7.4%) had both, and 60 (26.0%) had no abnormality. A total of 231 patients (mean age, 55.7 years; 64.5% women) were randomly assigned and followed up (median duration, 19.9 [12.6-26.9] months). The clinician diagnosed vasomotor angina in 51 (44.3%) patients in the intervention group and in 55 (47.4%) patients in the control group. After randomization, patients in the intervention group were 4-fold (odds ratio, 4.05 [95% CI, 2.32-7.24]; P <0.001) more likely to be diagnosed with a coronary vasomotor disorder; the frequency of this diagnosis increased to 76.5%. The frequency of normal coronary function (ie, no vasomotor disorder) was not different between the groups before randomization (51.3% versus 50.9%) but was reduced in the intervention group after randomization (23.5% versus 50.9%, P <0.001). At 6 and 12 months, the Seattle Angina Questionnaire summary score in the intervention versus control groups was 59.2±24.2 (2.3±16.2 change from baseline) versus 60.4±23.9 (4.6±16.4 change) and 63.7±23.5 (4.7±14.7 change) versus 66.0±19.3 (7.9±17.1 change), respectively, and not different between groups (global P =0.36). Compared with the control group, global treatment satisfaction was higher in the intervention group at 12 months (69.9±22.8 versus 61.7±26.9, P =0.013).
Conclusions: For patients with angina and no obstructive coronary arteries, a diagnosis informed by invasive functional assessment had no effect on long-term angina burden, whereas treatment satisfaction improved.
Registration: URL: https://www.
Clinicaltrials: gov; Unique identifier: NCT03477890.

5. Australian time traveller: papers in honour of Mike Archer [2023]

  • Beck, Robin M. D., Louys, Julien, Nguyen, Jacqueline M. T., Travouillon, Kenny J., and Wilson, Laura A. B.
  • Alcheringa; October 2023, Vol. 47 Issue: 4 p367-369, 3p
Abstract
Robin M. D. Beck [r.m.d.beck@salford.ac.uk], School of Science, Engineering and Environment, University of Salford, Manchester M5 4WT, UK. Julien Louys [j.louys@griffith.edu.au], Australian Research Centre for Human Evolution, Griffith University, Brisbane, Australia. Jacqueline M. T. Nguyen [jacqueline.nguyen@flinders.edu.au], Australian Museum Research Institute, 1 William Street, Sydney NSW 2010 Australia; College of Science and Engineering, Flinders University, GPO Box 2100, Adelaide SA 5001 Australia; and South Australian Museum, North Terrace, Adelaide SA 5000 Australia. Kenny J. Travouillon [Kenny.Travouillon@museum.wa.gov.au], Collections and Research, Western Australian Museum, Welshpool, Western Australia 6106, Australia. Laura A. B. Wilson [laura.wilson@anu.edu.au], School of Archaeology and Anthropology, The Australian National University, Canberra, ACT 2601, Australia; School of Biological, Earth and Environmental Sciences, UNSW, Sydney, NSW 2052, Australia.

6. The 24-hour food frequency assessment screening tool (FAST24): Development and evaluation of a novel dietary screener to identify foods associated with weight change. [2023]

  • Masheb RM, Vernarelli JA, Snow JL, Marsh AG, Ciszewski S, Dudley B, White CA, Purcell SA, and Lutes L
  • Clinical nutrition ESPEN [Clin Nutr ESPEN] 2023 Oct; Vol. 57, pp. 735-738. Date of Electronic Publication: 2023 Aug 24.
Subjects
United States, Female, Humans, Adolescent, Young Adult, Adult, Male, Databases, Factual, Diet, and Food
Abstract
Background & Aims: Brief screening questionnaires can identify 'at risk' behaviors in clinical settings. However, there is currently no screener for dietary intake specifically developed using foods associated with body weight change and increased risk for multiple chronic conditions and diseases.
Methods: We developed a novel brief dietary screener, the 24-Hour Food Frequency Assessment Screening Tool Questionnaire (FAST24), to identify intake of foods associated with weight change. University students completed the FAST24 and the Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24) at two time points to assess acceptability and determine preliminary criterion validity against food categories from the United States Department of Agriculture (USDA) Food Patterns Equivalents Database (FPED).
Results: 202 individuals (age 20.4 ± 3.6 years; 65.7% females) completed the FAST24 in an average time of 2 min compared to 24 min for the ASA24. Over half of the food items from the FAST24 were matched to, and correlated with, standard USDA food pattern components (r's ranging from .15 to .58, p's < .05). Food items from the dietary data from the FAST24 were also highly correlated with the more intensive ASA24 application (r's ranging from .23 to .82, p's < .01), and were less time-consuming and burdensome to complete (p's < .0001).
Conclusions: Findings support the continued refinement of the FAST24 as a rapid, valid primary care assessment tool for measuring USDA dietary intake patterns. Use of a short, simple screener such as the FAST24 has the potential for integration into large healthcare delivery settings to help establish a baseline for promoting relative behavior changes critical for long-term health and well-being.
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
(Published by Elsevier Ltd.)

7. Prevalence of parental supply of alcohol to minors: a systematic review. [2023]

  • van der Kruk S, Harrison NJ, Bartram A, Newton S, Miller C, Room R, Olver I, and Bowden J
  • Health promotion international [Health Promot Int] 2023 Oct 01; Vol. 38 (5).
Abstract
Parental supply of alcohol to minors (i.e. those under the legal drinking age) is often perceived by parents as protective against harms from drinking, despite evidence linking it with adverse alcohol-related outcomes. This systematic review describes the prevalence of parental supply of alcohol, as reported in the international literature. The review was registered with PROSPERO (CRD42020218754). We searched seven online databases (Medline, Embase, PsycINFO, CINAHL, Scopus, Web of Science and Public Health Database) and grey literature from January 2011 to December 2022 and assessed the risk of bias with the JBI Critical Appraisal Checklist. Among 58 articles included in narrative synthesis from 29 unique datasets, there was substantial variation in the definition and measurement of parental supply of alcohol. Overall prevalence rates ranged from 7.0 to 60.0% for minor-report samples, and from 24.0 to 8.0% for parent-report samples. Data indicate that parental supply prevalence is generally proportionately higher for older minors or later-stage students, for girls, and has increased over time among minors who report drinking. Literature on the prevalence of parental supply of alcohol is robust in quantity but inconsistent in quality and reported prevalence. Greater consistency in defining and measuring parental supply is needed to better inform health promotion initiatives aimed at increasing parents' awareness.
(© The Author(s) 2023. Published by Oxford University Press.)

8. Book Reviews [2023]

  • Ezung, Elilo, Parry, Robin, Whiscombe, Nell, Heath, Jane, Rathbone, Richard, Bradley, Ian, Pedersen, Else Marie Wiberg, Taylor, Kevin, Methuen, Charlotte, Doll, Peter, Nichols, Bridget, Newport, Kenneth, Thompson, David, Cunliffe, Christopher, Doll, Peter, Louth, Andrew, Chapman, Mark, Boughton, Gillian, deVries, Jacqueline, Doll, Peter, Dorsett, Mark, Chandler, Andrew, Brierley, Michael, Chapman, Mark, Byrne, Georgina, Chandler, Andrew, Dorsett, Mark, Chapman, Mark, Helmer, Christine, Gorringe, Tim, Norris, Kristopher, Muers, Rachel, Miles, Rebekah, Grumett, David, Coates, Ruth, Knight, Frances, Chandler, Andrew, Boughton, Gillian, Rzepa, Joanna, Loades, Ann, Kolpinskaya, Ekaterina, Harries, Richard, and Ritchie, Angus
  • Modern Believing; October 2023, Vol. 64 Issue: 4 p419-505, 87p

9. Intraprofessional collaboration among graduate and undergraduate nursing students: A simulated pilot project. [2023]

  • Martinez, Rebecca, Wiggins, Heather, Webb, Jacqueline, Claudson, Robin, and Barfield, Patricia
  • Teaching & Learning in Nursing; Oct2023, Vol. 18 Issue 4, pe259-e263, 5p
Abstract
• Simulation is an effective strategy to teach intraprofessional collaboration among undergraduate and graduate nursing students. • Students demonstrated a better understanding in nursing roles and team work following the simulated encounter. • The use of simulation in graduate and undergraduate nursing education can promote intraprofessional collaboration in practice. Nurse educators must be equipped to instruct nursing students on intraprofessional practice within primary care. A simulated primary care visit was piloted with graduate and undergraduate nursing students using telehealth technology and standardized patients. Students completed the Interprofessional Collaborative Competency Attainment Scale (ICCAS) , which revealed improvement in student perceived ability to communicate, collaborate, and understand the nursing roles and responsibilities. Simulating intraprofessional practice is a novel strategy to educate nurses for the primary care setting [ABSTRACT FROM AUTHOR]

10. Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial [2023]

  • Turkova, Anna, White, Ellen, Kekitiinwa, Adeodata R, Mumbiro, Vivian, Kaudha, Elizabeth, Liberty, Afaaf, Ahimbisibwe, Grace Miriam, Moloantoa, Tumelo, Srirompotong, Ussanee, Mosia, Nozibusiso Rejoice, Puthanakit, Thanyawee, Kobbe, Robin, Fortuny, Clàudia, Kataike, Hajira, Bbuye, Dickson, Na-Rajsima, Sathaporn, Coelho, Alexandra, Lugemwa, Abbas, Bwakura-Dangarembizi, Mutsa F, Klein, Nigel, Mujuru, Hilda A, Kityo, Cissy, Cotton, Mark F, Ferrand, Rashida A, Giaquinto, Carlo, Rojo, Pablo, Violari, Avy, Gibb, Diana M, Ford, Deborah, Mehar (nee Abdulla), Amina Farhana, Abraham, Pattamukkil, Abrams, Elaine, Acero, Judith, Agaba, Gerald Muzorah, Ahimbisibwe, Grace, Ainebyoona, Barbara, Akobye, Winnie, Akhalwaya, Yasmeen, Akoojee, Nazim, Ali, Shabinah S., Amuge, Pauline, Andrea, Catherine, Muñoz Fernandez, Maria Angeles, Ankunda, Rogers, Rutebarika, Diana Antonia, Anugulruengkitt, Suvaporn, Apollo, Tsitsi, Archary, Moherndran, Arendze, Ronelle, Ategeka, Juliet, Atim, Eunice, Atwine, Lorna, Babiker, Abdel, Babirye, Sarah, Babu, Enock, Bagirigomwa, Edward, Baita, Angella, Balamusani, David, Baliram, Patsy, Baliruno, David, Ball, Colin, Balwa, Henry, Bamford, Alasdair, Bandi, Srini, Barker, Dominique, Barlow-Mosha, Linda, Bbuye, Dickson, Begum, Shazia, Behuhuma, Osee, Bernays, Sarah, Besigye, Rogers, Bester, Maria, Bhiri, Joyline, Bilardi, Davide, Bird, Kristien, Bollen, Pauline, Borg, Chiara, Borges Da Silva, Anne-Marie, Brown, Jackie, Bruno, Elena, Bunupuradah, Torsak, Burger, David, Buthelezi, Nomzamo, Bwakura-Dangarembizi, Mutsa, Byaruhanga, Africanus, Calvert, Joanna, Casey, Petronelle, Cassim, Haseena, Cebekhulu, Sphiwee, Chailert, Sanuphong, Chalermpantmetagul, Suwalai, Chamjamrat, Wanna, Chan, Man, Chandiwana, Precious, Chankun, Thannapat, Chanthaburanun, Sararut, Chanto, Nuttawut, Chidziva, Ennie, Chikowore, Minenhle, Chimanzi, Joy, Chinwong, Dujrudee, Chitongo, Stuart, Chitsamatanga, Moses, Choga, Joshua, Chutima, Duangrat, Clayden, Polly, Coelho, Alexandra, Colbers, Angela, Compagnucci, Alexandra, Constança Mendes, Ana, Conway, Magda, Cotton, Mark F, Crawley, Jane, Cressey, Tim R, Crisp, Jacky, Matos, Ana Cristina, Dadan, Sumaya, Daglish, Jacqui, Danaviah, Siva, Daniel, Tseleng, De Rossi, Anita, Denjanta, Sukanda, Dobbels, Els, Dowie, Maria, Dube, Prosper, Dube, Benedictor, Dudakia, Nimisha, Elwana, Alice, Epalza, Cristina, Eram, David, Erasmus, Juan, Erim, Peter, Escosa Garcia, Luis, Essack, Zaakirah, Estepa, Carolina, Etima, Monica, Fernandes, Alexandre, Fernandez, Maite, Fitzgerald, Felicity, Flynn, Jacquie, Ford, Deborah, Fortuny Guasch, Claudia, Foster, Caroline, Fourie, George, Fourie, Yolandie, Foxall, Sophie, Frank, Derusha, Gandhi, Kate, Garcia, India, Gartner, Kathleen, Gasa, Joshua, Gasa, Gugu, Giaquinto, Carlo, Gibb, Diana M, Gomez Rico, Coral, Gomez-Pena, Daniel, Gondo, Secrecy, Goodman, Anna, Gorreti Nakalema, Maria, Gozhora, Winnie, Greetanukroh, Pisut, Gregorio Maranon, Biobanco, Grossele, Tiziana, Gwande, Shamiso, Gwaze, Tapiwa, Gwenzi, Tsitsi, Hakim, James, Hakiza, Emmanuel, Kaka, Abdul Hamid, Harley, Ashley, Isaacs, Mornay, Isabirye, Richard, Ishemunyoro, Wilber, Jacobs, Tom, Jafta, Lungile, Jamil, Nasir, Janse van Rensburg, Anita Janse, Jeaven, Vinesh, Mellado Peña, Maria José, Jourdain, Gonzague, Juliet, Katabalwa, Jumpimai, Thidarat, Junkaew, Raungwit, Jupimai, Thidarat, Kaahwa, Winfred, Kabasonga, Mildred, Kaboggoza, Olivia, Kadhuba, Rose Jacqueline, Kaewbundit, Ampika, Kaewmamueng, Kanyanee, Kafufu, Bosco, Kakayi, Brenda, Kamboua, Phakamas, Kanjanavanit, Suparat, Kasangaki, Gladys, Kasipong, Naruporn, Kasozi, Miriam, Kataike, Hajira, Katemba, Chrispus, Kaudha, Elizabeth, Kekane, Nkata, Kekitiinwa, Adeodata R, Keminyeto, Edridah, Khamduang, Woottichai, Khamjakkaew, Warunee, Khamkon, Jiraporn, Khannak, Sasipass, Khatngam, Orapin, Khayanchoomnoom, Tassawan, Khumalo, Busi, Khunene, Mirriam, Khusuwan, Suwimon, Kibalama, Phionah, Kibenge, Robinah, Kirabira, Anthony, Kityo, Cissy M, Kiyimba, Lameck, Klein, Nigel, Klinprung, Soraya, Kobbe, Robin, Kobusingye, Olivia, Kobusungye, Josephine, Kongponoi, Areerat, Königs, Christoph, Koole, Olivier, Kouakam, Christelle, Krueduangkam, Nitinart, Kruenual, Namthip, Kunjaroenrut, Nuananong, Kyambadde, Raymonds, Kyobutungi, Priscilla, Kyomuhendo, Flavia, Kyomukama, Erinah, Lakha, Reshma, Langa, Cleopatra, Laomanit, Laddawan, Lebotsa, Emily, Leenasirimakul, Prattana, Lekku, Lawrence, Lensen, Sarah, Leroy, Valériane, Li, Jin, Liberty, Afaaf, Limplertjareanwanich, Juthamas, Little, Emma, Lugemwa, Abbas, Lutalo, Ezra, Jimenez, Jose Luis, Lyall, Hermione, MacDonald, Candice, Machache, Gladness, Madlala, Penelope, Madonsela, Tryphina, Maduna, Nomfundo, Maena, Joel, Mahanontharit, Apicha, Makanga, Collin, Makola, Candice, Makumbi, Shafic, Malgraaf, Lucille, Mamiane, Angelous, Mantkowski, Felicia, Mapfumo, Wendy, Marques, Laura, Mugagga, Agnes Mary, Maseko, Lindiwe, Masienyane, Tshepiso, Mathiba, Ruth, Matimba, Farai, Mawlana, Sajeeda, Mayanja, Emmanuel, Mayat, Fatima, Mbabazi, Ritah, Mbadaliga, Nokuthula, Mbasani, Faith, McClaughlin, Kathleen, McIlleron, Helen, Meethaisong, Watchara, Mendez Garcia, Patricia, Miwanda, Annet, Miranda, Carlota, Mkhize, Siphiwe, Mmolawa, Kgosimang, Mngqibisa, Rosie, Mohamed, Fatima, Moloantoa, Tumelo, Monametsi, Maletsatsi, Montero, Samuel, Moore, Cecilia L, Mosia, Rejoice, Moyo, Columbus, Mthethwa, Mumsy, Mudzingwa, Shepherd, Mudzviti, Tawona, Mujuru, Hilda, Mujyambere, Emmanuel, Mukanganiki, Trust, Mukisa Williams, Cynthia, Mulder, Mark, Mulima, Disan, Mulindwa, Alice, Mumbiro, Vivian, Mupambireyi, Zivai, Murciano Cabeza, Alba, Murungi, Herbert, Murungu, Dorothy, Musarurwa, Sandra, Musiime, Victor, Musiime, Alex V, Musisi, Maria, Musoke, Philippa, Musoke Nakirya, Barbara, Musoro, Godfrey, Musumba, Sharif, Mustafa, Sobia, Mutsai, Shirley, Mwesigwa Rubondo, Phyllis, Naabalamba, Mariam, Nagawa, Immaculate, Naidoo, Allemah, Nakabuye, Shamim, Nakabuye, Sarah, Nakalanzi, Sarah, Nalubwama, Justine, Nalugo, Annet, Nalusiba, Stella, Namajja, Clementine, Namanda, Sylvia, Namayanja, Paula, Nambi, Esther, Namuddu, Rachael Kikabi, Namukwaya, Stella, Namuli, Florence, Namusanje, Josephine, Namwanje, Rosemary, Nanan-kanjee, Anusha, Nanduudu, Annet, Nankunda, Charity, Baddokwaya, Joanita Nankya, Nannungi, Maria, Nansamba, Winnie, Nanthapisal, Kesdao, Nanyonjo, Juliet, Na-Rajsima, Sathaporn, Nasaazi, Claire, Nascimento, Helena, Nastouli, Eleni, Songtaweesin, Wipaporn Natalie, Nathoo, Kusum, Natuhurira, Ian, Nazzinda, Rashidah, Ncgaba, Thabisa, Ndigendawani, Milly, Ndlovu, Makhosonke, Nentsa, Georgina, Ngampiyaskul, Chaiwat, Ngcobo, Ntombenhle, Ngo Giang Huong, Nicole, Ngwaru, Pia, Nhema, Ruth, Ninsiima, Emily, Ninsiima, Gloria, Nkalo Phiri, Misheck, Noguera Julian, Antoni, Nolan, Monica, Noppakaorattanamanee, Thornthun, Nsibuka Kisekka, Muzamil, Nsirim, Eniola, Nundlal, Rashina, Nunes, Rosita, Nyantsa, Lungile, Nyati, Mandisa, O'Riordan, Sean, Ocitti Labeja, Paul, Odoch, Denis, Oguntimehin, Rachel, Ojok, Martin, Onen, Geoffrey, Orange, Wilma, Ounchanum, Pradthana, Ouma, Benson, Padrao, Andreia, Pako, Deborah, Parker, Anna, Pasko-Szcech, Malgorzata, Patel, Reena, Peongjakta, Rukchanok, Petpranee, Turian, Phillips, Tasmin, Philps, Jackie, Picault, Laura, Pieterse, Sonja, Pinheiro, Helena, Pongprapass, Supawadee, Pozniak, Anton, Prendergast, Andrew, Prieto Tato, Luis, Puangmalai, Patcharee, Puthanakit, Thanyawee, Rakgokong, Modiehi, Ramos, Helena, Ramsagar, Nastassja, Rau, Cornelius, Riault, Yoann, Rojo Conejo, Pablo, Clark, Basiimwa Roy, Rubanga, Eddie, Rubinga, Baker, Ruklao, Chutima, Runarassamee, Pattira, Rutebarika, Diana Antonia, Saenjum, Chalermpong, Saewtrakool, Chayakorn, Saidi, Yacine, Sainz Costa, Talia, Saisaengjan, Chutima, Sakwa, Rebecca, Sarfati, Tatiana, Sbisi, Noshalaza, Scheppers, Dihedile, Schultze-Strasser, Stephan, Schulze-Sturm, Ulf, Scott, Karen, Seeley, Janet, Serunjogi, Robert, Sewnarain, Leora, Shakeshaft, Clare, Sidhoo, Subashinie, Shibemba, Mercy, Shingadia, Delane, Singh, Sheleika, Sirirungsi, Wasna, Sithebe, Sibongile, Smit, Theresa, Smith, Kurt, Smuts, Marlize, Spyer, Moira, Sripaoraya, Worathip, Srirompotong, Ussanee, Srisuk, Warunee, Ssenyonga, Mark, Sudsaard, Patamawadee, Sukrakanchana, Praornsuda, Tearsansern, Pathanee, Teixeira, Carla, Than-in-at, Kanchana, Thapwai, Thitiwat, Thaweesombat, Yupawan, Thewsoongnoen, Jutarat, Thiébaut, Rodolphe, Thomason, Margaret, Thrasyvoulou, Laura, Thungkham, Khanungnit, Tikabibamu, Judith, Tinago, Gloria, Trairat, Ketmookda, Tudor-Williams, Gareth, Tukamushaba, Mercy, Tukwasibwe, Deogratiuos, Tumusiime, Julius, Tuna, Joana, Turkova, Anna, Turner, Rebecca, Udomvised, Arttasid, Vadee, Aasia, Van Huyssteen, Hesti, Van Looy, Nadine, Variava, Ebrahim, Vaughan-Gordon, Yvonne, Vecchia, Giulio, Violari, Avy, Vowden, Richard, Waalewijn, Hylke, Wampamba, Rebecca, Welch, Steve, Weller, Ian, Weza, Sibusisiwe, White, Ellen, White, Ian, Widuch, Kaja, Wilkes, Helen, Wimonklang, Sookpanee, Wynne, Ben, Yingyong, Pacharaporn, Nakawungu, Zaam Zinda, and Zuidewind, Peter
  • The Lancet Child & Adolescent Health; October 2023, Vol. 7 Issue: 10 p718-727, 10p
Abstract
Cohort studies in adults with HIV showed that dolutegravir was associated with neuropsychiatric adverse events and sleep problems, yet data are scarce in children and adolescents. We aimed to evaluate neuropsychiatric manifestations in children and adolescents treated with dolutegravir-based treatment versus alternative antiretroviral therapy.

11. Novel Liver Injury Phenotypes and Outcomes in Pulmonary Arterial Hypertension. [2023]

  • Scott JV, Moutchia J, McClelland RL, Al-Naamani N, Weinberg E, Palevsky HI, Minhas J, Appleby DK, Smith A, Pugliese SC, Ventetuolo CE, and Kawut SM
  • MedRxiv : the preprint server for health sciences [medRxiv] 2023 Sep 30. Date of Electronic Publication: 2023 Sep 30.
Abstract
Background: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are disorders of the pulmonary vasculature that cause right ventricular dysfunction. Systemic consequences of right ventricular dysfunction include damage to other solid organs, such as the liver. However, the profiles and consequences of hepatic injury due to PAH and CTEPH have not been well-studied.
Methods: We aimed to identify underlying patterns of liver injury in a cohort of PAH and CTEPH patients enrolled in 15 randomized clinical trials conducted between 1998 and 2012. We used unsupervised machine learning to identify liver injury clusters in 13 trials and validated the findings in two additional trials. We then determined whether these liver injury clusters were associated with clinical outcomes or treatment effect heterogeneity.
Results: Our training dataset included 4,219 patients and our validation dataset included 1,756 patients with complete liver laboratory panels (serum total bilirubin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and albumin). Using k-means clustering paired with factor analysis, we identified four unique liver phenotypes (no liver injury, hepatocellular injury, cholestatic injury, and combined injury patterns). Patients in the cholestatic injury liver cluster had the shortest time to clinical worsening and highest chance of worsening World Health Organization functional class. Randomization to the experimental arm was associated with a transition to healthier liver clusters compared to randomization to the control arm. The cholestatic injury group experienced the greatest placebo-corrected treatment benefit in terms of six-minute walk distance.
Conclusions: Liver injury patterns were associated with adverse outcomes in patients with PAH and CTEPH. Randomization to active treatment of pulmonary hypertension in these clinical trials had beneficial effects on liver health compared to placebo. The independent role of liver disease (often subclinical) in determining outcomes warrants prospective studies of the clinical utility of liver phenotyping for PAH prognosis and contribution to clinical disease.

12. Innovative Technologies in CNS Trials: Promises and Pitfalls for Recruitment, Retention, and Representativeness. [2023]

  • Lutz J, Pratap A, Lenze EJ, Bestha D, Lipschitz JM, Karantzoulis S, Vaidyanathan U, Robin J, Horan W, Brannan S, Mittoux A, Davis MC, Lakhan SE, and Keefe R
  • Innovations in clinical neuroscience [Innov Clin Neurosci] 2023 Sep 01; Vol. 20 (7-9), pp. 40-46. Date of Electronic Publication: 2023 Sep 01 (Print Publication: 2023).
Abstract
Objective: Recruitment of a sufficiently large and representative patient sample and its retention during central nervous system (CNS) trials presents major challenges for study sponsors. Technological advances are reshaping clinical trial operations to meet these challenges, and the COVID-19 pandemic further accelerated this development.
Method of Research: The International Society for CNS Clinical Trials and Methodology (ISCTM; www.isctm.org) Innovative Technologies for CNS Trials Working Group surveyed the state of technological innovations for improved recruitment and retention and assessed their promises and pitfalls.
Results: Online advertisement and electronic patient registries can enhance recruitment, but challenges with sample representativeness, conversion rates from eligible prescreening to enrolled patients, data privacy and security, and patient identification remain hurdles for optimal use of these technologies. Electronic medical records (EMR) mining with artificial intelligence (AI)/machine learning (ML) methods is promising but awaits translation into trials. During the study treatment phase, technological innovations increasingly support participant retention, including adherence with the investigational treatment. Digital tools for adherence and retention support take many forms, including patient-centric communication channels between researchers and participants, real-time study reminders, and digital behavioral interventions to increase study compliance. However, such tools add technical complexities to trials, and their impact on the generalizability of results are largely unknown.
Conclusion: Overall, the group found a scarcity of systematic data directly assessing the impact of technological innovations on study recruitment and retention in CNS trials, even for strategies with already high adoption, such as online recruitment. Given the added complexity and costs associated with most technological innovations, such data is needed to fully harness technologies for CNS trials and drive further adoption.
Competing Interests: DISCLOSURES: Dr. Lutz may have equity interests with Click Therapeutics, Inc. Dr. Lenze has previously consulted for Merck, Prodeo, Boehringer Ingelheim, Pritikin ICR, and IngenioRx; he has previously received funding from PCORI, the COVID-19 Early Treatment Fund, Mercatus/FastGrants, and Janssen; and he has a patent pending for sigma1 receptor agonists for COVID-19 treatment. Dr. Vaidyanathan was an employee of Boehringer Ingelheim at the time of writing. Dr. Robin is an employee of Winterlight Labs, Inc. and has equity interests with Winterlight Labs, Inc. Dr. Horan was an employee of WCG VeraSci at the time of writing, and is now an employee of Karuna Therapeutics. Dr. Brannan is an employee at Karuna Therapeutics. Dr. Lakhan is employed by Click Therapeutics, Inc. and has equity interests. Dr. Keefe serves as a paid consultant to WCG, Karuna, Merck, Sunovion, Biogen, and Boehringer Ingelheim. All other authors have no conflicts of interest relevant to the contents of this article.
(Copyright © 2023. Matrix Medical Communications. All rights reserved.)

13. CMR-derived left ventricular intraventricular pressure gradients identify different patterns associated with prognosis in dilated cardiomyopathy. [2023]

  • Vos JL, Raafs AG, Henkens MTHM, Pedrizzetti G, van Deursen CJ, Rodwell L, Heymans SRB, and Nijveldt R
  • European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2023 Aug 23; Vol. 24 (9), pp. 1231-1240.
Subjects
Humans, Contrast Media, Ventricular Pressure, Magnetic Resonance Imaging, Cine, Gadolinium, Ventricular Function, Left, Stroke Volume, Magnetic Resonance Spectroscopy, Prognosis, Predictive Value of Tests, and Cardiomyopathy, Dilated
Abstract
Aims: Left ventricular (LV) blood flow is determined by intraventricular pressure gradients (IVPG). Changes in blood flow initiate remodelling and precede functional decline. Novel cardiac magnetic resonance (CMR) post-processing LV-IVPG analysis might provide a sensitive marker of LV function in dilated cardiomyopathy (DCM). Therefore, the aim of our study was to evaluate LV-IVPG patterns and their prognostic value in DCM.
Methods and Results: LV-IVPGs between apex and base were measured on standard CMR cine images in DCM patients (n = 447) from the Maastricht Cardiomyopathy registry. Major adverse cardiovascular events, including heart failure hospitalisations, life-threatening arrhythmias, and sudden/cardiac death, occurred in 66 DCM patients (15%). A temporary LV-IVPG reversal during systolic-diastolic transition, leading to a prolonged transition period or slower filling, was present in 168 patients (38%). In 14%, this led to a reversal of blood flow, which predicted outcome corrected for univariable predictors [hazard ratio (HR) = 2.57, 95% confidence interval (1.01-6.51), P = 0.047]. In patients without pressure reversal (n = 279), impaired overall LV-IVPG [HR = 0.91 (0.83-0.99), P = 0.033], systolic ejection force [HR = 0.91 (0.86-0.96), P < 0.001], and E-wave decelerative force [HR = 0.83 (0.73-0.94), P = 0.003] predicted outcome, independent of known predictors (age, sex, New York Heart Association class ≥ 3, LV ejection fraction, late gadolinium enhancement, LV-longitudinal strain, left atrium (LA) volume-index, and LA-conduit strain).
Conclusion: Pressure reversal during systolic-diastolic transition was observed in one-third of DCM patients, and reversal of blood flow direction predicted worse outcome. In the absence of pressure reversal, lower systolic ejection force, E-wave decelerative force (end of passive LV filling), and overall LV-IVPG are powerful predictors of outcome, independent of clinical and imaging parameters.
Competing Interests: Conflict of interest: None declared.
(© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)

14. Brain Imaging Abnormalities in Mixed Alzheimer’s and Subcortical Vascular Dementia [2023]

  • Lee, Hyunwoo, Wiggermann, Vanessa, Rauscher, Alexander, Kames, Christian, Beg, Mirza Faisal, Popuri, Karteek, Tam, Roger, Lam, Kevin, Jacova, Claudia, Shahinfard, Elham, Sossi, Vesna, Pettersen, Jacqueline A., and Hsiung, Ging-Yuek Robin
  • The Canadian Journal of Neurological Sciences; July 2023, Vol. 50 Issue: 4 p515-528, 14p
Abstract
ABSTRACT:Background:A large proportion of Alzheimer’s disease (AD) patients have coexisting subcortical vascular dementia (SVaD), a condition referred to as mixed dementia (MixD). Brain imaging features of MixD presumably include those of cerebrovascular disease and AD pathology, but are difficult to characterize due to their heterogeneity.Objective:To perform an exploratory analysis of conventional and non-conventional structural magnetic resonance imaging (MRI) abnormalities in MixD and to compare them to those observed in AD and SVaD.Methods:We conducted a cross-sectional, region-of-interest-based analysis of 1) hyperintense white-matter signal abnormalities (WMSA) on T2-FLAIR and hypointense WMSA on T1-weighted MRI; 2) diffusion tensor imaging; 3) quantitative susceptibility mapping; and 4) effective transverse relaxation rate (R2*) in N = 17 participants (AD:5, SVaD:5, MixD:7). General linear model was used to explore group differences in these brain imaging measures.Results:Model findings suggested imaging characteristics specific to our MixD group, including 1) higher burden of WMSAs on T1-weighted MRI (versus both AD and SVaD); 2) frontal lobar preponderance of WMSAs on both T2-FLAIR and T1-weighted MRI; 3) higher fractional anisotropy values within normal-appear white-matter tissues (versus SVaD, but not AD); and 4) lower R2* values within the T2-FLAIR WMSA areas (versus both AD and SVaD).Conclusion:These findings suggest a preliminary picture of the location and type of brain imaging characteristics associated with MixD. Future imaging studies may employ region-specific hypotheses to distinguish MixD more rigorously from AD or SVaD.

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16. Left Atrial Strain Is an Independent Predictor of New-Onset Atrial Fibrillation in Dilated Cardiomyopathy. [2023]

  • Raafs AG, Vos JL, Henkens MTHM, Verdonschot JAJ, Sikking M, Stroeks S, Gerretsen S, Hazebroek MR, Knackstedt C, Nijveldt R, and Heymans SRB
  • JACC. Cardiovascular imaging [JACC Cardiovasc Imaging] 2023 Jul; Vol. 16 (7), pp. 991-992. Date of Electronic Publication: 2023 Mar 08.
Subjects
Humans, Predictive Value of Tests, Heart Atria diagnostic imaging, Echocardiography, Atrial Fibrillation diagnostic imaging, Atrial Fibrillation etiology, and Cardiomyopathy, Dilated diagnostic imaging

17. Author Correction: The power of genetic diversity in genome-wide association studies of lipids. [2023]

  • Graham SE, Clarke SL, Wu KH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, Choudhury A, Bentley AR, Ekoru K, Verma A, Trivedi B, Martin HC, Hunt KA, Hui Q, Klarin D, Zhu X, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Ruotsalainen SE, Havulinna AS, Veturi Y, Feng Q, Rosenthal EA, Lingren T, Pacheco JA, Pendergrass SA, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Hindy G, Rasheed A, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Willemsen G, Wood AR, Ji Y, Gao Z, Haworth S, Mitchell RE, Chai JF, Aadahl M, Yao J, Manichaikul A, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Sabater-Lleal M, Noordam R, Sidore C, Fiorillo E, McDaid AF, Marques-Vidal P, Wielscher M, Trompet S, Sattar N, Møllehave LT, Thuesen BH, Munz M, Zeng L, Huang J, Yang B, Poveda A, Kurbasic A, Lamina C, Forer L, Scholz M, Galesloot TE, Bradfield JP, Daw EW, Zmuda JM, Mitchell JS, Fuchsberger C, Christensen H, Brody JA, Feitosa MF, Wojczynski MK, Preuss M, Mangino M, Christofidou P, Verweij N, Benjamins JW, Engmann J, Kember RL, Slieker RC, Lo KS, Zilhao NR, Le P, Kleber ME, Delgado GE, Huo S, Ikeda DD, Iha H, Yang J, Liu J, Leonard HL, Marten J, Schmidt B, Arendt M, Smyth LJ, Cañadas-Garre M, Wang C, Nakatochi M, Wong A, Hutri-Kähönen N, Sim X, Xia R, Huerta-Chagoya A, Fernandez-Lopez JC, Lyssenko V, Ahmed M, Jackson AU, Yousri NA, Irvin MR, Oldmeadow C, Kim HN, Ryu S, Timmers PRHJ, Arbeeva L, Dorajoo R, Lange LA, Chai X, Prasad G, Lorés-Motta L, Pauper M, Long J, Li X, Theusch E, Takeuchi F, Spracklen CN, Loukola A, Bollepalli S, Warner SC, Wang YX, Wei WB, Nutile T, Ruggiero D, Sung YJ, Hung YJ, Chen S, Liu F, Yang J, Kentistou KA, Gorski M, Brumat M, Meidtner K, Bielak LF, Smith JA, Hebbar P, Farmaki AE, Hofer E, Lin M, Xue C, Zhang J, Concas MP, Vaccargiu S, van der Most PJ, Pitkänen N, Cade BE, Lee J, van der Laan SW, Chitrala KN, Weiss S, Zimmermann ME, Lee JY, Choi HS, Nethander M, Freitag-Wolf S, Southam L, Rayner NW, Wang CA, Lin SY, Wang JS, Couture C, Lyytikäinen LP, Nikus K, Cuellar-Partida G, Vestergaard H, Hildalgo B, Giannakopoulou O, Cai Q, Obura MO, van Setten J, Li X, Schwander K, Terzikhan N, Shin JH, Jackson RD, Reiner AP, Martin LW, Chen Z, Li L, Highland HM, Young KL, Kawaguchi T, Thiery J, Bis JC, Nadkarni GN, Launer LJ, Li H, Nalls MA, Raitakari OT, Ichihara S, Wild SH, Nelson CP, Campbell H, Jäger S, Nabika T, Al-Mulla F, Niinikoski H, Braund PS, Kolcic I, Kovacs P, Giardoglou T, Katsuya T, Bhatti KF, de Kleijn D, de Borst GJ, Kim EK, Adams HHH, Ikram MA, Zhu X, Asselbergs FW, Kraaijeveld AO, Beulens JWJ, Shu XO, Rallidis LS, Pedersen O, Hansen T, Mitchell P, Hewitt AW, Kähönen M, Pérusse L, Bouchard C, Tönjes A, Chen YI, Pennell CE, Mori TA, Lieb W, Franke A, Ohlsson C, Mellström D, Cho YS, Lee H, Yuan JM, Koh WP, Rhee SY, Woo JT, Heid IM, Stark KJ, Völzke H, Homuth G, Evans MK, Zonderman AB, Polasek O, Pasterkamp G, Hoefer IE, Redline S, Pahkala K, Oldehinkel AJ, Snieder H, Biino G, Schmidt R, Schmidt H, Chen YE, Bandinelli S, Dedoussis G, Thanaraj TA, Kardia SLR, Kato N, Schulze MB, Girotto G, Jung B, Böger CA, Joshi PK, Bennett DA, De Jager PL, Lu X, Mamakou V, Brown M, Caulfield MJ, Munroe PB, Guo X, Ciullo M, Jonas JB, Samani NJ, Kaprio J, Pajukanta P, Adair LS, Bechayda SA, de Silva HJ, Wickremasinghe AR, Krauss RM, Wu JY, Zheng W, den Hollander AI, Bharadwaj D, Correa A, Wilson JG, Lind L, Heng CK, Nelson AE, Golightly YM, Wilson JF, Penninx B, Kim HL, Attia J, Scott RJ, Rao DC, Arnett DK, Hunt SC, Walker M, Koistinen HA, Chandak GR, Yajnik CS, Mercader JM, Tusié-Luna T, Aguilar-Salinas CA, Villalpando CG, Orozco L, Fornage M, Tai ES, van Dam RM, Lehtimäki T, Chaturvedi N, Yokota M, Liu J, Reilly DF, McKnight AJ, Kee F, Jöckel KH, McCarthy MI, Palmer CNA, Vitart V, Hayward C, Simonsick E, van Duijn CM, Lu F, Qu J, Hishigaki H, Lin X, März W, Parra EJ, Cruz M, Gudnason V, Tardif JC, Lettre G, 't Hart LM, Elders PJM, Damrauer SM, Kumari M, Kivimaki M, van der Harst P, Spector TD, Loos RJF, Province MA, Psaty BM, Brandslund I, Pramstaller PP, Christensen K, Ripatti S, Widén E, Hakonarson H, Grant SFA, Kiemeney LALM, de Graaf J, Loeffler M, Kronenberg F, Gu D, Erdmann J, Schunkert H, Franks PW, Linneberg A, Jukema JW, Khera AV, Männikkö M, Jarvelin MR, Kutalik Z, Cucca F, Mook-Kanamori DO, van Dijk KW, Watkins H, Strachan DP, Grarup N, Sever P, Poulter N, Rotter JI, Dantoft TM, Karpe F, Neville MJ, Timpson NJ, Cheng CY, Wong TY, Khor CC, Sabanayagam C, Peters A, Gieger C, Hattersley AT, Pedersen NL, Magnusson PKE, Boomsma DI, de Geus EJC, Cupples LA, van Meurs JBJ, Ghanbari M, Gordon-Larsen P, Huang W, Kim YJ, Tabara Y, Wareham NJ, Langenberg C, Zeggini E, Kuusisto J, Laakso M, Ingelsson E, Abecasis G, Chambers JC, Kooner JS, de Vries PS, Morrison AC, North KE, Daviglus M, Kraft P, Martin NG, Whitfield JB, Abbas S, Saleheen D, Walters RG, Holmes MV, Black C, Smith BH, Justice AE, Baras A, Buring JE, Ridker PM, Chasman DI, Kooperberg C, Wei WQ, Jarvik GP, Namjou B, Hayes MG, Ritchie MD, Jousilahti P, Salomaa V, Hveem K, Åsvold BO, Kubo M, Kamatani Y, Okada Y, Murakami Y, Thorsteinsdottir U, Stefansson K, Ho YL, Lynch JA, Rader DJ, Tsao PS, Chang KM, Cho K, O'Donnell CJ, Gaziano JM, Wilson P, Rotimi CN, Hazelhurst S, Ramsay M, Trembath RC, van Heel DA, Tamiya G, Yamamoto M, Kim BJ, Mohlke KL, Frayling TM, Hirschhorn JN, Kathiresan S, Boehnke M, Natarajan P, Peloso GM, Brown CD, Morris AP, Assimes TL, Deloukas P, Sun YV, and Willer CJ
  • Nature [Nature] 2023 Jun; Vol. 618 (7965), pp. E19-E20.

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19. Left Atrial Function in Patients with Titin Cardiomyopathy. [2023]

  • Henkens MTHM, Raafs AG, Vanloon T, Vos JL, Vandenwijngaard A, Brunner HG, Krapels IPC, Knackstedt C, Gerretsen S, Hazebroek MR, Vernooy K, Nijveldt R, Lumens J, and Verdonschot JAJ
  • Journal of cardiac failure [J Card Fail] 2023 May 23. Date of Electronic Publication: 2023 May 23.
Abstract
Background: Truncating variants in titin (TTNtv) are the most prevalent genetic etiology of dilated cardiomyopathy (DCM). Although TTNtv has been associated with atrial fibrillation, it remains unknown whether and how left atrial (LA) function differs between patients with DCM with and without TTNtv. We aimed to determine and compare LA function in patients with DCM with and without TTNtv and to evaluate whether and how left ventricular (LV) function affects the LA using computational modeling.
Methods and Results: Patients with DCM from the Maastricht DCM registry that underwent genetic testing and cardiovascular magnetic resonance (CMR) were included in the current study. Subsequent computational modeling (CircAdapt model) was performed to identify potential LV and LA myocardial hemodynamic substrates. In total, 377 patients with DCM (n = 42 with TTNtv, n = 335 without a genetic variant) were included (median age 55 years, interquartile range [IQR] 46-62 years, 62% men). Patients with TTNtv had a larger LA volume and decreased LA strain compared with patients without a genetic variant (LA volume index 60 mLm -2 [IQR 49-83] vs 51 mLm -2 [IQR 42-64]; LA reservoir strain 24% [IQR 10-29] vs 28% [IQR 20-34]; LA booster strain 9% [IQR 4-14] vs 14% [IQR 10-17], respectively; all P < .01). Computational modeling suggests that while the observed LV dysfunction partially explains the observed LA dysfunction in the patients with TTNtv, both intrinsic LV and LA dysfunction are present in patients with and without a TTNtv.
Conclusions: Patients with DCM with TTNtv have more severe LA dysfunction compared with patients without a genetic variant. Insights from computational modeling suggest that both intrinsic LV and LA dysfunction are present in patients with DCM with and without TTNtv.
Competing Interests: Declaration of Competing Interest The authors have no conflict of interest.
(Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)

20. Does believing something to be fiction allow a form of moral licencing or a 'fictive pass' in understanding others' actions? [2023]

  • Thompson J, Teasdale B, van Emde Boas E, Budelmann F, Duncan S, Maguire L, and Dunbar R
  • Frontiers in psychology [Front Psychol] 2023 May 15; Vol. 14, pp. 1159866. Date of Electronic Publication: 2023 May 15 (Print Publication: 2023).
Abstract
Introduction: The human capacity to engage with fictional worlds raises important psychological questions about the mechanisms that make this possible. Of particular interest is whether people respond differently to fictional stories compared to factual ones in terms of how immersed they become and how they view the characters involved and their actions. It has been suggested that fiction provides us with a 'fictive pass' that allows us to evaluate in a more balanced, detached way the morality of a character's behaviour.
Methods: We use a randomised controlled experimental design to test this.
Results and Discussion: We show that, although knowing whether a substantial film clip is fact or fiction does not affect how engaged with ('transported' by) a troubling story an observer becomes, it does grant them a 'fictive pass' to empathise with a moral transgressor. However, a fictive pass does not override the capacity to judge the causes of a character's moral transgression (at least as indexed by a causal attribution task).
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Thompson, Teasdale, van Emde Boas, Budelmann, Duncan, Maguire and Dunbar.)

21. Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design. [2023]

  • Gross R, Thaweethai T, Rosenzweig EB, Chan J, Chibnik LB, Cicek MS, Elliott AJ, Flaherman VJ, Foulkes AS, Witvliet MG, Gallagher R, Gennaro ML, Jernigan TL, Karlson EW, Katz SD, Kinser PA, Kleinman LC, Lamendola-Essel MF, Milner JD, Mohandas S, Mudumbi PC, Newburger JW, Rhee KE, Salisbury AL, Snowden JN, Stein CR, Stockwell MS, Tantisira KG, Thomason ME, Truong DT, Warburton D, Wood JC, Ahmed S, Akerlundh A, Alshawabkeh AN, Anderson BR, Aschner JL, Atz AM, Aupperle RL, Baker FC, Balaraman V, Banerjee D, Barch DM, Baskin-Sommers A, Bhuiyan S, Bind MC, Bogie AL, Buchbinder NC, Bueler E, Bükülmez H, Casey BJ, Chang L, Clark DB, Clifton RG, Clouser KN, Cottrell L, Cowan K, D'Sa V, Dapretto M, Dasgupta S, Dehority W, Dummer KB, Elias MD, Esquenazi-Karonika S, Evans DN, Faustino EVS, Fiks AG, Forsha D, Foxe JJ, Friedman NP, Fry G, Gaur S, Gee DG, Gray KM, Harahsheh AS, Heath AC, Heitzeg MM, Hester CM, Hill S, Hobart-Porter L, Hong TKF, Horowitz CR, Hsia DS, Huentelman M, Hummel KD, Iacono WG, Irby K, Jacobus J, Jacoby VL, Jone PN, Kaelber DC, Kasmarcak TJ, Kluko MJ, Kosut JS, Laird AR, Landeo-Gutierrez J, Lang SM, Larson CL, Lim PPC, Lisdahl KM, McCrindle BW, McCulloh RJ, Mendelsohn AL, Metz TD, Morgan LM, Müller-Oehring EM, Nahin ER, Neale MC, Ness-Cochinwala M, Nolan SM, Oliveira CR, Oster ME, Payne RM, Raissy H, Randall IG, Rao S, Reeder HT, Rosas JM, Russell MW, Sabati AA, Sanil Y, Sato AI, Schechter MS, Selvarangan R, Shakti D, Sharma K, Squeglia LM, Stevenson MD, Szmuszkovicz J, Talavera-Barber MM, Teufel RJ 2nd, Thacker D, Udosen MM, Warner MR, Watson SE, Werzberger A, Weyer JC, Wood MJ, Yin HS, Zempsky WT, Zimmerman E, and Dreyer BP
  • MedRxiv : the preprint server for health sciences [medRxiv] 2023 May 12. Date of Electronic Publication: 2023 May 12.
Abstract
Importance: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults.
Observations: We describe the protocol for the Pediatric Observational Cohort Study of the NIH's RE searching COV ID to E nhance R ecovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study of caregiver-child pairs (birth through 17 years) and young adults (18 through 25 years), recruited from more than 100 sites across the US. This report focuses on two of five cohorts that comprise RECOVER-Pediatrics: 1) a de novo RECOVER prospective cohort of children and young adults with and without previous or current infection; and 2) an extant cohort derived from the Adolescent Brain Cognitive Development (ABCD) study ( n =10,000). The de novo cohort incorporates three tiers of data collection: 1) remote baseline assessments (Tier 1, n=6000); 2) longitudinal follow-up for up to 4 years (Tier 2, n=6000); and 3) a subset of participants, primarily the most severely affected by PASC, who will undergo deep phenotyping to explore PASC pathophysiology (Tier 3, n=600). Youth enrolled in the ABCD study participate in Tier 1. The pediatric protocol was developed as a collaborative partnership of investigators, patients, researchers, clinicians, community partners, and federal partners, intentionally promoting inclusivity and diversity. The protocol is adaptive to facilitate responses to emerging science.
Conclusions and Relevance: RECOVER-Pediatrics seeks to characterize the clinical course, underlying mechanisms, and long-term effects of PASC from birth through 25 years old. RECOVER-Pediatrics is designed to elucidate the epidemiology, four-year clinical course, and sociodemographic correlates of pediatric PASC. The data and biosamples will allow examination of mechanistic hypotheses and biomarkers, thus providing insights into potential therapeutic interventions.
Clinical Trialsgov Identifier: Clinical Trial Registration: http://www.clinicaltrials.gov . Unique identifier: NCT05172011.

22. Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial [2023]

  • Abani, Obbina, Abbas, Ali, Abbas, Fatima, Abbas, Joshua, Abbas, Kasim, Abbas, Mustafa, Abbasi, Sadia, Abbass, Hakam, Abbott, Alfie, Abbott, Alison, Abdallah, Nabeel, Abdelaziz, Ammar, Abdelaziz, Ashraf, Abdelfattah, Mohamed, Abdelqader, Bushra, Abdul, Audrey, Abdul, Basir, Abdul, Siddiqui, Abdul Rasheed, Althaf, Abdulakeem, Ajibode, Abdul-Kadir, Rezan, Abdullah, Abdullah, Abdulmumeen, Abdulfatahi, Abdul-Raheem, Rasheed, Abdulshukkoor, Niyaz, Abdusamad, Kula, Abed El Khaleq, Yazeed, Abedalla, Mai, Abeer Ul Amna, Abeer, Abel, Lynn, Abernethy, Katrina, Abeywickrema, Movin, Abhinaya, Chandra, Abidin, Affyarsyah, Aboaba, Adebanke, Aboagye-Odei, Abigail, Aboah, Christopher, Aboelela, Heba, Abo-Leyah, Hani, Abouelela, Karim, Abou-Haggar, Ahmed, Abouibrahim, Mahmoud, Abousamra, Ahmed, Abouzaid, Mona, Abraham, Miriam, Abraham, Tizzy, Abraheem, Abraheem, Abrams, Judith, Abrams, Rebecca, Abu, Hyacinth-John, Abu-Arafeh, Ahmed, Abubacker, Syed M, Abung, Akata, Abusamra, Yousuf, Aceampong, Yaa, Achara, Amaka, Acharya, Devikumar, Acheampong, Faustina, Acheampong, Prince, Acheampong, Sarah, Acheson, Janet, Achieng, Shiella, Acosta, Andres, Acquah, Rebecca, Acton, Catherine, Adabie-Ankrah, Jacqueline, Adair, Paul, Adam, Fiona, Adam, Matthew, Adamali, Huzaifa, Adamczyk, Marta, Adams, Carol, Adams, Charlotte, Adams, Daniel, Adams, Kate, Adams, Laura, Adams, Nikkita, Adams, Richard, Adams, Tim, Adamu-Ikeme, Laura, Adatia, Krishma, Adcock, Kirsty, Addai-Boampong, Lawrence, Addo, Afua, Adeagbo, Oluwatobi, Adebiyi, Ade, Adedeji, Ogunlana, Adegeye, Yewande, Adegoke, Ken, Adell, Vicki, Adenwalla, Sherna, Adeoye, Femi W, Adesemoye, Oluwasegun A, Adewunmi, Emmanuel O, Adeyanju, Adedamola, Adeyemi, Joyce, Adeyemo, Tenifayo, Adhikari, Binay, Adhikari, Shanti A, Adhikary, Rina, Aditya, Adhikarla, Adjepong, Patience, Adkins, Gabrielle, Adnan, Adnan, Adriaanse, Marguerite, Aeron-Thomas, John, Affleck, Debbie, Afnan, Carmel, Afridi, Muhammad, Afrim, Patricia, Afriyie, Felicia Akua, Aftab, 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Benton, Ian, Beranova, Eva, Beresford, Matthew, Bergin, Colin, Bergstrom, Malin, Bernatoniene, Jolanta, Berriman, Thomas, Berry, Zoe, Best, Frida, Best, Kimberley, Bester, Ans-Mari, Beuvink, Yvonne, Bevan, Emily, Bevins, Sarah, Bewick, Tom, Bexley, Andrew, Beyatli, Sonay, Beynon, Fenella, Bhadi, Arjun, Bhagani, Sanjay, Bhakta, Shiv, Bhalla, Rekha, Bhandal, Khushpreet, Bhandal, Kulbinder, Bhandari, Ashwin, Bhandari, Lila Nath, Bhandari, Sangam, Bhanich Supapol, Jennifer, Bhanot, Aashutosh, Bhanot, Ravina, Bhasin, Swati, Bhat, Abdul, Bhat, Prashanth, Bhatnagar, Rahul, Bhatt, Karan, Bhayani, Janki, Bhojwani, Deepika, Bhuie, Parminder, Bhuiyan, M S, Bhuiyan, Salimuzzaman, Bibby, Anna, Bibi, Fatima, Bibi, Naheeda, Bibi, Salma, Bicanic, Tihana, Bidgood, Sarah, Bigg, Julie, Biggs, Sarah, Biju, Alphonsa, Bikov, Andras, Billingham, Sophie, Billings, Jessica, Binh, Prof, Binns, Alice, BinRofaie, Muhammad, Bintcliffe, Oliver, Birch, Catherine, Birch, Janine, Birch, Jenny, Birchall, Katherine, Bird, Sam, Bird, Sumedha, Bird, Sarah, Birt, Mark, Bishop, Claire, Bishop, Kilanalei, Bishop, Linda, Bishop, Lisa, Bisnauthsing, Karen, Biswas, Nibedan, Bittaye, Mustapha, Biuk, Sahar, Blachford, Karen, Black, Ethel, Black, Helen, Black, Karen, Black, Mairead, Black, Polly, Black, Virginia, Blackgrove, Hayley, Blackledge, Bethan, Blackler, Joanne, Blackley, Samantha, Blackman, Helen, Blackstock, Caroline, Blair, Cameron, Blakemore, Francesca, Blamey, Helen, Bland, Alison, Blane, Sujata, Blankley, Simon, Blaxill, Parry, Blaylock, Katie, Blazeby, Jane, Blencowe, Natalie, Bloom, Ben, Bloomfield, Jack, Bloss, Angela, Blowers, Alex, Blows, Samuel, Bloxham, Hannah, Blrd, Susan, Blundell, Louise, Blunsum, Andrew, Blunt, Mark, Blunt, Tadhg, Blyth, Ian, Blyth, Kevin, Blythe, Andrew, Blythe, Karen, Boahen, Kwabena Appiah, Boampoaa, Marilyn, Board, Sarah, Bobie, Boniface, Bobruk, Karen, Bodalia, Pritesh N, Bodasing, Neena, Boden, Marianne, Bodenham, Tanya, Boehmer, Gabriele, Boffito, Marta, Bohanan, Katherine, Bohmova, Kristyna, Bohnacker, Niamh, Bokhandi, Sumit, Bokhar, Maria, Bokhari, Saba, Bokhari, Sakina, Bokhari, Syed O, Bokobza, Idan, Boles, Ambrose, Bolger, Clare, Bonaconsa, Candice, Bond, Charlotte, Bond, Helena, Bond, Stuart, Bond, Thomas, Bone, Alice, Boniface, Georgia, Bonney, Joseph, Bonney, Lizzy, Booker, Lauren, Boot, Sarah, Boothroyd, Matthew, Borbone, Joanne, Borman, Naomi, Bosence, Samantha, Bostock, Kirsty, Botting, Neil, Bottrill, Fiona, Bouattia, Hannah, Bough, Laura, Boughton, Hayley, Boult, Zoe, Boumrah, Tarek, Bourke, Miriam, Bourke, Stephen, Bourne, Michelle, Bousfield, Rachel, Boustred, Lucy, Bowes, Alexandra, Bowes, Amy, Bowker, Philip, Bowker, Tabitha, Bowler, Helen, Bowman, Louise, Bowman, Simon, Bowmer, Rachel, Bowring, Angie, Bowyer, Helen, Boyd, Aileen, Boyd, Jenny, Boyd, Laura, Boyer, Nicola, Boyle, Namoi, Boyle, Pauline, Boyle, Rosalind, Boyles, Louise, Brace, Leanna, Bracken, Abbey, Bradder, Jodie, Bradley, Clare J, Bradley, Pamela, Bradley, Patrick, Bradley, Paul, Bradley-Potts, Joanne, Bradshaw, Lynne, Bradshaw, Zena, Brady, Clare, Brady, Rebecca, Brady, Shirin, Braga Sardo, Pedro, Braganza, Denise, Braithwaite, Megan, Brammer, Susan, Branch, Marie, Brankin-Frisby, Thomas, Brannigan, Jamie, Brattan, Sophie, Bray, Fiona, Bray, Nancy, Brazil, Manny, Brear, Lucy, Brear, Tracy, Brearey, Stephen, Bremner, Laura, Brend, Morwenna, Bresges, Carolin, Bressington, Catherine, Bretland, Giovanna, Brewer, Chris, Bridgett, Michael, Bridgwood, Gavin, Brigham, Sara, Bright, John, Brightling, Christopher, Brigstock, Tracey, Brimfield, Lutece, Brinksman, Philip, Brinkworth, Elaine, Brittain-Long, Robin, Britten, Vianne, Britton, Hannah, Broad, Lauren, Broadhead, Sarah, Broadhurst, Rosie, Broadley, Andrew, Broadway, Marie, Brockelsby, Christopher, Brocken, Megan, Brockley, Tomos, Brodsky, Mary, Brogan, Fiona, Brohan, Liz, Brokke, Felicity, Brolly, Jacob, Bromley, David, Brooke-Ball, Hannah, Brooker, Verity, Brookes, Matthew, 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Carol, Budds, Alex, Bugg, George, Bujazia, Ramadan, Bukhari, Marwan, Bukhari, Shanze, Bulbulia, Richard, Bull, Alex, Bull, Damian, Bull, Kate, Bull, Rhian, Bull, Thomas, Bullock, Emily, Bullock, Susan, Bulteel, Naomi, Bumunarachchi, Kasun, Bungue-Tuble, Roneleeh, Burbidge, Oliver, Burchett, Caroline, Burda, Dorota, Burden, Christy, Burden, Thomas G, Burgess, Mika, Burgess, Richard, Burgess, Sophia, Burhan, Erlina, Burhan, Hasan, Burke, Hannah, Burke, Kerry, Burman, Adrian, Burnard, Sara, Burnett, Caroline, Burnett, Sharon, Burns, Amy, Burns, Collette, Burns, James, Burns, Karen, Burns, Kiki, Burrage, Daniel, Burrows, Kate, Burston, Claire, Burton, Anna, Burton, Ben, Burton, Fiona, Burton, Helen, Burton, Matthew, Butar butar, Mannaria, Butcher, Deborah, Butler, Aaron, Butler, Emily, Butler, Jessica, Butler, Joanne, Butler, Joshua, Butler, Peter, Butler, Susan, Butler, Jenny, Butt, Al-Tahoor, Butt, Massawer, Butt, Mohammad M, Butterworth, Caryl, Butterworth-Cowin, Nicola, Buttery, Robert, Buttle, Tom, Button, Heather, Buttress, Daniel, Bye, Hannah, Byrne, Jane, Byrne, Wendy, Byrne-Watts, Victoria, Cabandugama, Amanda, Cabrero, Luisa, Caddy, Simone, Cade, Ruth, Cadwgan, Anthony, Cahilog, Zhen, Cahyareny, Ajeng, Cairney, Donna, Calderwood, James, Caldow, Darren, Cale, Emily, Calisti, Giorgio, Callaghan, Debbie, Callaghan, Jennifer, Callens, Claire, Callum, Donaldson, Calver, Caroline, Cambell-Kelly, Melissa, Camburn, Tracey, Cameron, David R, Cameron, Eleanor, Cameron, Fraser, Cameron, Sheena, Camm, Christian, Cammack, Renee F D, Campbell, Alison, Campbell, Amy, Campbell, Barbara, Campbell, Bridget, Campbell, Debbie, Campbell, Helen, Campbell, Hilary, Campbell, Jonathan, Campbell, Karen, Campbell, Marion, Campbell, Mark, Campbell, Rachael, Campbell, Robyn, Campbell, Wynny, Campbell Hewson, Quentin, Camsooksai, Julie, Canclini, Lisa, Candido, Shaula M, Candlish, Janie, Caneja, Cielito, Cann, Alexandra, Cann, Johnathon, Cannan, Ruby, Cannon, Abigail, Cannon, Emma, Cannon, Michael, Cannon, Petra, Cannons, Vivienne, Canonizado, Ebnier, Cantliff, Jane, Caplin, Ben, Capocci, Santino, Caponi, Noemi, Capp, Angelika, Capstick, Richard, Capstick, Thomas, Caraenache, Catalin, Card, Aimee, Cardwell, Mary, Carey, Charles, Carey, Rachel, Carley, Simon, Carlin, Ffion, Carlin, Tammy, Carmichael, Samantha, Carmody, Margaret, Carnahan, Mandy, Caroline, Charlotte, Carpenter, Jodi, Carr, Sharon, Carrasco, Anna, Carrington, Zoe, Carroll, Amy, Carroll, Anne, Carroll, Paul, Carson, Rachel, Cart, Cindy, Carter, Emma, Carter, Jonathan, Carter, Michael, Carter, Natasha, Carter, Paul, Carter, Penny, Cartwright, Douglas, Cartwright, Jo-Anne, Carty, Claire, Carty, Lotoyah, Carungcong, Jaime, Carver, Charlotte, Carver, Emma, Carver, Rachel, Casey, Susan, Cassells, Annie, Castiello, Teresa, Castle, Gail, Castles, Bridget, Caswell, Melanie, Catana, Ana Maria, Cate, Heidi, Catelan Zborowski, Anelise, Cathcart, Susanne, Cathie, Katrina, Catibog, Darwin, Catley, Christine, Catlow, Laura, Caudwell, Matthew, Cavazza, Anna, Cave, Ashleigh, Cave, Luke, Cavinato, Simon, Cawa, Frianne, Cawley, Kathryn, Caws, Chloe, Cawthorne, Kay, Cendl, Hankins, Century, Hannah, Cernova, Jeva, Cesay, Mansur, Cetti, Ed, Chabane, Stephanie, Chablani, Manish, Chabo, Cathleen, Chacko, Cyril J, Chadwick, David, Chadwick, Julie, Chadwick, Robert, Chakkarapani, Ela, Chakraborty, Arup, Chakraborty, Mallinath, Chakravorty, Mollika, Chalakova, Petya, Chalise, Bimal Sharma, Chalmers, James, Chalmers, Richard, Chamberlain, Georgina, Chamberlain, Sarah, Chambers, Emma, Chambers, Jonathan, Chambers, Lucy, Chambers, Naomi, Chan, Alex, Chan, Carmen, Chan, Cheuk, Chan, Evelyn, Chan, Jay Marie, Chan, Kawai, Chan, Kayen, Chan, Kimberley, Chan, Ping, Chan, Rebekah (Pui-Ching), Chan, Xin H S, Chandler, Chris, Chandler, Heidi, Chandler, Kim J, Chandler, Stuart, Chandler, Zoe, Chandra, Sumit, Chandran, Navin, Chandrasekaran, Badrinathan, Chang, Yvonne, Chanh, Ho Quang, Chaplin, Grace, Chaplin, Josephine, Chapman, Graeme, Chapman, John, Chapman, Katie, Chapman, Laura, Chapman, Lianne, Chapman, Matthew, Chapman, Polly, Chapman, Timothy, Chappell, Lucy, Charalambou, Amanda, Charles, Bethan, Charlton, Dianne, Charlton, Sam, Chatar, Kevin, Chatha, Calvin, Chatterton, Debra, Chaube, Ritesh, Chaudhary, Muhammad Y N, Chaudhary, Netra B, Chaudhry, Iram, Chaudhry, Zain, Chaudhuri, Nazia, Chaudhury, Muhammad, Chauhan, Anoop, Chauhan, Ruchi S, Chavasse, Alexander, Chavasse, Nicola, Chawla, Vipal, Cheater, Lindsay, Cheaveau, James, Cheeld, Charlotte, Cheeseman, Michelle, Chen, Fang, Chen, Hui Min, Chen, Terence, Cheng, Floria, Cheng, Lok Yin, Cheng, Zhihang, Chenoweth, Helen, Cheong, Chun How, Cherian, Shiney, Cherrie, Mary, Cheshire, Helen, Cheung, Chee Kay, Cheung, Elaine, Cheung, Kayan, Cheung, Michelle, Cheyne, Claire, Chhabra, Swati, Chia, Wei Ling, Chiang, Eric, Chiapparino, Angela, Chicano, Rosavic, Chikungwa, Moses, Chikwanha, Zviedzo A, Chilcott, Gemma, Chilcott, Sam, Chilvers, Alison, Chimbo, Phillipa, Chin, KokWai, Chin, Wen Jie, Chineka, Rumbidzai, Chingale, Amol, Chinonso, Ezomike, Chin-Saad, Chloe, Chirgwin, Margaret, Chisem, Heather, Chisenga, Claire, Chisholm, Catherine, Chisnall, Ben, Chiswick, Carolyn, Chita, Sunder, Chitalia, Nihil, Chiu, Matthew, Chiverton, Laura, Chivima, Brenda, Chmiel, Catherine, Choi, Soha, Choon Kon Yune, Willy, Chopra, Meena, Chopra, Michelle, Choudhary, Vandana, Choudhury, Omur, Choudhury, Sarah, Chow, Bing-Lun, Chowdhury, Mahibbur, Chowdhury, Shahid, Chrisopoulou, Angela, Christenssen, Victoria, Christian, Peter, Christides, Alexander, Christie, Fiona, Christmas, Daniel, Christoforou, Georgios, Christopherson, Thereza, Christou, Anna, Christy, Mark, Chrysostomou, Paris, Chua, Yunli, Chudgar, Dip, Chudleigh, Richard, Chukkambotla, Srikanth, Chukwu, Michael E, Chukwulobelu, Izu, Chung, Chi Yee, Church, Elaine, Church, Sara R, Churchill, David, Cianci, Nicole, Cicconi, Paola, Cinardo, Paola, Cipinova, Zdenka, Cipriano, Bessie, Clamp, Sarah, Clancy, Bridget, Clapham, Melanie, Clare, Edel, Clare, Sarbjit, Clark, Andrew, Clark, Charlotte, Clark, Diane, Clark, Emma, Clark, Felicity, Clark, Gabrielle, Clark, James, Clark, Julia, Clark, Katherine, Clark, Kaylea, Clark, Louise, Clark, Lucy, Clark, Martyn, Clark, Matthew, Clark, Nicola, Clark, Patricia, Clark, Richard, Clark, Thomas, Clark, Tonia, Clark, Zoe, Clarke, Alison, Clarke, Andrea, Clarke, Jude, Clarke, Paul, Clarke, Robert, Clarke, Roseanne, Clarke, Samantha, Clarke, Sheron, Claxton, Alleyna, Claxton, Louis, Clay, Kate, Clayton, Catherine, Clayton, Elizabeth, Clayton, Olivia, Clayton-Smith, Jill, Clearyb, Bethan, Cleaver, Chris, Cleeton, Rose, Clement, Ian, Clemente de la Torre, Carlota, Clements, Jayne, Clements, Suzanne, Clenton, Sue, Cliff, Sheryl, Clifford, Rachael, Clifford, Sarah, Clive, Amelia, Clouston, Jonathan, Clubb, Vincent, Clueit, Samantha, Clutterbuck, Lisa, Clyne, Andrea, Coakley, Michelle, Coakley, Peter G L, Cobain, Kathryn, Cochrane, Alexandra, Cochrane, Patricia, Cockayne, Laura, Cockerell, Maeve, Cockerill, Helen, Cocks, Shirley, Codling, Rachel, Coe, Adam, Coetzee, Samantha, Coey, David, Cohen, Danielle, Cohen, Jonathan, Cohen, Oliver, Cohen, David, Cohn, Mike, Coke, Louise, Coker, Olutoyin, Colbeck, Nicholas, Colbert, Roghan, Cole, Esther, Cole, Jade, Cole, Joby, Coleman, Garry, Coleman, Matt, Coleman, Nick, Coles, Holly, Colin, Macleod, Colino-Acevedo, Alicia, Colley, Julie, Collie, Kathleen, Collier, Alexandra, Collier, Danielle, Collier, Dawn, Collier, Heather, Collingwood, Terry, Collini, Paul, Collins, Emma, Collins, Jaimie, Collins, Joanne, Collins, Kayleigh, Collins, Megan, Collins, Nicola, Collins, Sally, Collins, Vicky, Collinson, Andrew, Collinson, Bernadette, Collinson, Jennifer, Collis, Matthew, Colmar, Madeleine, Colton, Hayley E, Colton, James, Colville, Katie, Colvin, Carolyn, Combes, Edward, Comer, David, Comerford, Alison, Concannon, Dónal, Condliffe, Alison, Condliffe, Robin, Connell, Emma, Connell, Lynne, Connell, Natalie, Connelly, Karen, Connolly, Gavin, Connor, Emma, Conroy, Antonia, Conroy, Kevin, Conteh, Veronica, Convery, Rory, Conway, Francesca, Conway, Grainne, Conway, Rhiannon, Conway, Robert, Conyngham, Jo-Anna, Cook, Amanda, Cook, Amber, Cook, Colette, Cook, Eloise, Cook, Gemma, Cook, Helen, Cook, Julie, Cook, Martin, Cook, Sarah, Cooke, Danielle, Cooke, Graham, Cooke, Hannah, Cooke, Justin, Cooke, Katrina, Cooke, Tim, Cooke, Vikki, Cooper, Adele, Cooper, Chris, Cooper, David, Cooper, Helen, Cooper, Jamie, Cooper, Lauren, Cooper, Nick, Cooper, Rowena, Cooray, Samantha, Cope, Thomas, Corbet, Sinead, Corbett, Carolyn, Corbishley, Ailsa, Corcoran, John, Cordell, Chris, Cordle, Jessica, Corfield, Alasdair, Corless, John, Corlett, Alison, Cornwell, Joe, Cornwell, Michael, Corogeanu, Diana, Corr, Aisling, Corredera, Mirella, Corrigan, Ruth, Corry, P, Corser, Rita, Cort, Jon, Cosgrove, Denise, Cosier, Tracey, Costa, Patricia, Costa, Telma, Coston, Charlie, Cotgrove, Susannah, Coton, Zoe, Cottam, Lisa-Jayne, Cotter, Rhiannon, Cotterill, Donna, Cotton, Caroline, Couch, George, Coulding, Martina, Coull, Andrew, Counsell, David, Counter, David, Coupland, Cherry, Courtney, Ellie, Courtney, Julia, Cousins, Rebecca, Coutts, Amanda J, Cowan, Alexander, Cowan, Elena, Cowan, Richard, Cowell, Richard, Cowen, Louise, Cowman, Steve, Cowton, Amanda, Cox, Ellie, Cox, Emma, Cox, Giles, Cox, Helen, Cox, Karina, Cox, Miriam, Coy, Karen, Cradduck-Bamford, Andrea, Craig, Hannah, Craig, Jayne, Craig, John, Craig, Victoria, Craighead, Felicity, Cramp, Matthew, Cranston, Hayley, Crasta, Sheetal S, Crause, Jacolene, Crawford, Angie, Crawford, Emma, Crawford, Isobel, Crawshaw, Sarah, Creagh-Brown, Ben, Creamer, Andrew, Creaser-Myers, Amanda, Cremona, Joanne, Cremona, Saveria, Crepet, Anna, Cresswell, Janet, Cribb, Mark, Crichton, Charles, Crilly, Declan, Crisp, Lauren, Crisp, Nikki, Crocombe, Dominic, Croft, Maria, Crooks, Jennifer, Crosby, Harriet, Cross, Elizabeth, Cross, Tim, Crothers, Amy, Crotty, Stephen, Crouch, Susan, Crow, Madeleine, Crowder, Amanda, Crowley, Kate, Crowley, Teresa, Croysdill, Rebecca, Cruickshank, Callum, Cruickshank, Conor, Cruickshank, Irena, Cruise, James, Cruz, Carina, Cruz Cervera, Trino, Cryans, Dominic, Cui, Guanguo, Cui, Helen, Cullen, Lorraine, Cummings-Fosong, Gillian, Cunliffe, Victoria, Cunningham, Neil, Cunningham, Nicola, Cupitt, Jason, Curgenven, Hollie, Curnow, Gerens, Curran, David, Curran, Simon, Currie, Craig, Currie, Jacqueline, Currie, Scarlett, Currie, Susan, Currie, Susie, Curtis, Jonathan, Curtis, Katrina, Curtis, Matthew, Curtis, Olivia, Curtis, Thomas, Cuthbertson, Rebecca, Cuthill, Jennifer, Cutler, Sean, Cutts, Sarah, Czekaj, Marta, Czylok, Patrycja, D'Souza, Shane, da Rocha, Joana, Dafalla, Mohammed, Dagens, Andrew, Daggett, Helen, Daglish, Jacqui, Dahiya, Sandeep, Dale, Anne, Dale, Katie, Dale, Michaela, Dale, Sam, Dale, Susan, Dales, Jolyon, D'Alessandro, Umberto, Dalgleish, Helen, Dallow, Helen, D'aloia, Carlo, Dalton, Dermot, Dalton, Morag, Daly, Zoe, Damani, Mansi, Damm, Eleanor, Danga, Akila, Dangerfield, Joanne, Daniel, Amelia, Daniel, Priya, Daniels, Allison, Dann, Adela, Danso, Kwaku Gyasi, Danso-Bamfo, Sandra, Dao, Quang Tung, Darby, Suzanne, Darbyshire, Alex, Darbyshire, Janet, Dargan, Paul, Dark, Paul, Darlington, Kate, Darnell, Sarah, Darton, Thomas, Darylile, Guledew, Das, Avisnata, Das, Manjusha, Das, Sukamal, Daschel, Martin, Dasgin, Joanne, Datta, Dibyendu, Daunt, Anna, Dave, Vaishali, Davenport, Emily, Davey, Mark, Davey, Miriam, Davey, Molly, David, Mini, Davidson, Alexander, Davidson, Laura, Davidson, Neil, Davidson, Richard, Davies, Albert, Davies, Alison, Davies, Amanda, Davies, Amy, Davies, Angela, Davies, Bethan, Davies, Caroline, Davies, Carolyn, Davies, Catrin, Davies, Dawn, Davies, Drew, Davies, Elaine, Davies, Elinor, Davies, Ellie, Davies, Ffyon, Davies, Gwyneth, Davies, Helen, Davies, Jennifer, Davies, Jim, Davies, Karen, Davies, Kelly, Davies, Kim, Davies, Llinos, Davies, Louisa, Davies, Matthew, Davies, Michelle, Davies, Nina, Davies, Owen, Davies, Patrick, Davies, Rachel, Davies, Rhys, Davies, Ruth, Davies, Sally, Davies, Sarah, Davies, Simon, Davies, Sue, Davis, Alison, Davis, Julie-Ann, Davis, Katherine, Davis, Peter, Davis-Cook, Andrea, Davison, Alexander, Dawe, Christine, Dawe, H, Dawkins, Mark, Dawson, Angela, Dawson, Danielle, Dawson, Elizabeth, Dawson, Joy, Dawson, Lucinda, Dawson, Mike, Dawson, Susan, Dawson, Tom, Dawson, Isla, Daxter, Andrew, Day, Andrew, Day, Jacob, Day, Jeremy N, D'Costa, Jamie, De, Parijat, De, Pradip, de Fonseka, Duneesha, de Freitas, Toni, De Los Santos Dominguez, Pamela, De Pretto, Roberta, De Santana Miranda, Frederico, de Sausmarez, Eleanor, de Silva, Shanika, de Silva, Thushan, De Sousa, Jessica, De Sousa, Paulo, de Souza, James, De Souza, Phillip, De Soyza, Anthony, de Vere, Natasha, de Vos, Johannes, Deacon, Bethan, Dealing, Sharon, Dean, Anna, Dean, Julie, Dean, Katrina, Dean, Stephen, Dean, Tessa, Deane, Jill, Dear, James, Dearden, Effie, Deas, Catherine, Debbie, Samuel, Debreceni, Gabor, Deelchand, Vashist, Deeley, Matthew, Deery, Joanne, Defever, Emmanuel, Del Forno, Manuela, Dela Rosa, Arnold, De-La-Cedra, Gonzalo, Dell, Amanda, Demetriou, Carrie, DeMets, David, Democratis, Jane, Denham, Jacqueline, Denis, Emmanuelle, Denley, Laura, Denmade, Craig, Dent, Alexandra, Dent, Kathy, Dent, Martin, Denton, Elise, Denwood, Tom, Deole, Nishigandh, Depala, Darshita, Depante, Maria, Dermody, Susan, Desai, Amisha, Desai, Asmita, Desai, Purav, Deshpande, Sanjeev, Deshpande, Vai, Devkota, Sirjana, Devkota, Usha, Devonport, Debbie, Devonport, Matthew, Dey, Prakash, Dey, Vishal, Deylami, Rogin, Dhaliwal, Kevin, Dhani, Sundip, Dhanoa, Amandeep, Dhar, Mili, Dhariwal, Ankush, Dharmasena, Dawpadee, Dhasmana, Devesh, Dhillon, Ekanjali, Dhillon, Reiss, Dhillon, Syra, Dhimal, Meghnath, Dhiru, Dipali, Dhorajiwala, Trupti, Dias, Priya, Diaz, Stephanie, Diaz-Pratt, Kayleigh, Dibas, Mohammed, Dickerson, Debbie, Dicks, Pamela, Dickson, Matt, Dickson, Stuart, Digby, J, Digpal, Ronneil, Dillane, Sean, Diment, Sarah, Dimitri, Paul, Dimitriadis, Georgios, Din, Sajeel, Dinh, Thai H, Dinh, Thi T T, Dipper, Alex, Dipro, Sabiq, Dirmantaite, Laura, Dismore, Lorelle, Ditchfield, Lisa, Diver, Sarah, Diwakar, Lavanya, Diwan, Preeti, Dixon, Caroline, Dixon, Giles, Dixon, Kate, Djeugam, Brice, Dlamini, Sipho, Dlouhy, Petr, D'Mello, Andrea, Dmitri, Paul, Do, Thi Tien, Dobbie, Laurence, Dobranszky Oroian, Marinela, Dobson, Charlotte, Dobson, Lee, Docherty, Marie, Dockrell, David, Dodd, Jacqueline, Dodd, James, Dodds, Jackie, Dodds, Rebecca, Dodds, Steve, Dogra, Richi, Doherty, Conor, Doherty, Erin, Doherty, Warren, Doi, Yumiko, Doig, Iain, Doke, Eleanor, Dolan, Daniel, Dolman, Mark, Dolman, Rozzie, Donald, Lisa, Donald, Katie, Donaldson, Callum, Donaldson, Christopher, Donaldson, Denise, Donaldson, Gillian, Donaldson, Kate, Dong, Phu Khiem, Donkor, Martha, Donlon, Sinead, Donnachie, Joanne, Donnelly, Eilish, Donnelly, Ronan, Donnison, Phil, Donohoe, Aravindhan, Donohoe, Gemma, Donohue, Bryan, Dooks, Emma, Doonan, Reece J, Van Doorn, Rogier, Doran, Grainne, Dore, Rachael, Dorey, Kane, Dorgan, Sharon, Dos Santos, Kataryna, Dosani, Moonira, Dosanjh, Davinder, Dospinescu, Paula, Doss, Isabelle, Doudouliaki, Theonymfi, Dougherty, Andrew, Doughty, Jill, Douglas, Katie, Douse, Jonathan, Dow, Allyn, Dowden, Lucy, Dower, Michelle, Dowling, Sud, Downer, Nicola, Downes, Charlotte, Downes, Rob, Downes, Thomas, Downey, Damian, Downey, Robert, Downing, Caroline, Downs, Louise, Dowson, Simon, Dragan, Cornel, Dragos, Cristina, Drain, Maire, Drake, Chelsea, Drew, Victoria, Drewett, Olivia, Drexel, Anthony, Driscoll, Celine, Drogan, Helena, Drosos, Odysseas, Drummond, Graham, Drury, Katie, Druryk, Kay, Druyeh, Ronald, Dryburgh-Jones, Jack, Drysdale, Simon, Du Thinh, An, Dube, Hazel, Dube, Judith, Duberley, Stephen, Duckenfield, Paige K, Duckles-Leech, Hayley, Duff, Nicola, Duffield, Emma, Duffy, Heather, Duffy, Helen, Duffy, Katharine, Dufour, Lionel, Duggan, Annette, Dugh, Parveen, Duhoky, Rauand, Duignan, Janice, Dulay, Jennifer, Dummer, Simon, Duncan, Alexis, Duncan, Andrew, Duncan, Christopher, Duncan, Fullerton, Duncan, Gregory, Duncan, Holly, Duncan, Robert, Dundas, Stephanie, Van Dung, Do, Dunleavy, Aileen, Dunleavy, Julia, Dunn, Alessia, Dunn, Charlotte, Dunn, Damian, Dunn, Laura, Dunn, Paul, Dunne, Charlene, Dunne, Karen, Dunning, Fiona, Dunphy, Aidan, Duong, Tran Thi Hai, Duraiswamy, Venkat, Duran, Beatriz, DuRand, Ingrid, Durdle, Leanne, Duric, Natalie, Durie, Alison, Durie, Emily, Durogbola, Samuel, Durojaiye, Chris, Durrans, Laura, Durrant, Katie, Durrington, Hannah, Duru, Iheukwumere, Duvnjak, Haris, Dwarakanath, Akshay, Dwarakanath, Laasya, Dwomoh Nkrumah, Dennis, Dwyer, Ellen, Dyar, Zara, Dyball, Claudia, Dyer, Kristyn, Dymond, Harvey, Dymond, Tom, Eades, Chris, Eadie, Lauren, Eadie, Rebekah, Eagles, Laura, Eapen, Beena, Earl, Naomi, Early, Joanne, Earwaker, Melissa, Easom, Nicholas, East, Clare, Easthope, Amy, Easton, Fraser, Easton, Jack, Easton, Patrick, Eatough, Ruth, Ebigbola, Oluwadamilola, Ebon, Martin, Eccles, Alison, Eccles, Sinan, Eddings, Chloe, Eddleston, Michael, Edgar, Maureen, Edgerley, Katharine, Edmond, Nicholas, Edmondson, Mary, Edmunds, Tracy, Edwards, Abby, Edwards, Alexandra, Edwards, Catherine, Edwards, Joy, Edwards, Kennedy, Edwards, Mandy, Edwards, Martin, Edwards, Sophie, Eedle, Jenny, Eggink, Aline, Egginton, Dawn, Eggleston, Sam, Ehiorobo, Loveth, Eisen, Sarah, Ekeowa, Ugochukwu, Ekoi, Mohamed, Ekunola, Ayomide, El Behery, Soha, Elashhar, Nagla, Elawamy, Lisa, Elbeshy, Mohamed, El-Bouzidi, Kate, Elder, Jennifer, El-Din, Mohammed, Eldridge, Emma, Eleanor, Diana, Elenwa, Uchenna, Eletu, Ibrahim, Elfar, Eman, Elgamal, Mayy Magdy, Elgohary, Amr, Elhadi, Mohamed A A, Elia, Stellios, Elias, Jennifer, Elias, Tania, Elkaram, Nadia, Elkins, Andrew V, Ellam, Julie, Ellard, Nikki, Ellerton, Laura N, Elliot, Lucy, Elliott, Amy, Elliott, Fiona, Elliott, Kerry, Elliott, Scott, Elliott, Sian, Ellis, Annie, Ellis, Christine, Ellis, Kaytie, Ellis, Leila, Ellis, Rupert, Ellis, Tak-Yan, Ellis, Yvette, Ellwood, Alison C, Elmahdi, Rahma, Elmahi, Einas, Elmasry, Hannah-May, El-Naggar, Mohammed, Elndari, Najla, Elneima, Omer, Elokl, Mohamed, Elradi, Ahmed, Elsaadany, Mohamed, Elsayed, Mohammed A S A, El-Sayeh, Sally, El-Sbahi, Hana, Elsebaei, Mohammad, Elsefi, Tarek, El-Shakankery, Karim, Elsheikh, Alguili, El-Taweel, Hosni, Elyoussfi, Sarah, Emberey, Jonathan, Emberson, Jonathan R, Emberton, John, Emery, Anna, Emmanuel, Julian, Emmerson, Ingrid, Emms, Michael, Emond, Florence, Emonts, Marieke, Enachi, Nicu, Enenche, Dickson, Engden, Angila, English, Katy, Entwistle, Emma, Enyi, Hene, Erotocritou, Marios, Eskander, Peter, Esmail, Hanif, Essa, Fatheha, Evans, Brynach, Evans, Chris, Evans, Debra, Evans, E, Evans, Emrys, Evans, Gail, Evans, Gareth, Evans, Isabel, Evans, Jack, Evans, Jacqueline, Evans, Jennifer, Evans, John, Evans, Jolanta, Evans, Lisa, Evans, Lynn, Evans, Mim, Evans, Morgan, Evans, Ranoromanana, Evans, Sharon, Evans, Sian, Evans, Teriann, Evans, Tomos, Everden, Caroline, Everden, Serenydd, Every, Lynette, Evison, Hayley, Evison, Lynsey, Ezenduka, Chiamaka, Faccenda, Jacqueline, Fahel, Leila, Fahmay, Youstina, Fairbairn, Ian, Fairbairn, Sara, Fairbairn, Terry, Fairclough, Andy, Fairlie, Louise, Fairweather, Mark, Fajardo, Anne, Falcone, Naomi, Falconer, Euan, Fallon, John, Fallow, Andrea, Faluyi, David, Fancois, Victoria, Farah, Ayaan, Farah, Muna, Farah, Qayyum, Fard, Nowin Z, Fares, Leila, Farg, Amr, Farmer, Adam, Farmer, Katie, Farmery, Toni, Farnworth, Samantha, Farook, Faiyaz, Farooq, Hadia, Farooq, Sidrah, Farquhar, Fiona, Farr, Holly, Farrell, Aaron, Farrell, Barbara, Farrukh, Fayed, Farthing, James, Farzana, Syeda, Fasina, Rahmatu, Fatemi, Azam, Fatemi, Mina, Fathima, Suman, Fatimah, Nibah, Faulkner, Maria, Faust, Saul N, Favager, Clair, Fawke, Joe, Fawohunre, Sinmidele, Fazal, Abul, Fazleen, Aisthath, Fearby, Simon, Fearnley, Connie, Feben, Alex, Fedel, Federico, Fedorova, Daria, Fegan, Christopher, Felongo, Mae, Felton, Lynsey, Felton, Tim, Fenlon, Kate, Fenn, Andrea, Fennelly, Ruth, Fenner, Isabelle, Fenton, Ciara, Fenton, Melisa, Ferenando, Gloria, Ferguson, Cameron, Ferguson, Jenny, Ferguson, Kathryn, Ferguson, Katie, Ferguson, Susan, Ferguson, Susie, Ferguson, Victoria, Fernandes, Denzil, Fernandez, Candida, Fernandez, Eduardo, Fernandez, Maria, Fernandez Lopez, Sonia, Fernandez Roman, Jaime, Fernando, Callum J, Fernando, Jessica, Feroz, Ahmed, Ferranti, Pietro, Ferrari, Thais, Ferrelly, Eleanor, Ferrera, Alexandra, Ferriman, Emma, Ferron, Sheldon, Fethers, Nicholas, Field, Ben, Field, Janet, Field, Rebecca, Fielder, Karen, Fieldhouse, Lindsey, Fielding, Andra, Fielding, Julie, Fielding, Sarah, Fikree, Asma, Filipa, Santos, Filson, Sarah A, Finan, Shona, Finbow, Sarah, Finch, Deborah J, Finch, Joanne, Finch, Laurie, Finch, Simon, Finch, Spencer, Fineman, Natalie, Finlayson, Jim, Finlayson, Lauren, Finn, Adam, Finn, Joanne, Finnerty, Dylan, Finney, Clare, Finucane, Deborah, Fiouni, Sofia, Fiquet, Jo, Firi, Promise, Fisher, James, Fisher, Neil, Fishman, Daniel, Fishwick, Krystofer, Fitton, Carolyn, Fitzgerald, Felicity, Fitzgerald, Fiona, Fitzjohn, Karen, Flaherty, Jan, Flanagan, Michael, Flanders, Charles, Flaris, Nikolaos, Fleming, Gail, Fleming, Julie, Fleming, Lucy, Fleming, Paul, Flesher, William, Fletcher, Alison, Fletcher, Anna, Fletcher, Jonathan, Fletcher, Lucy, Fletcher, Simon, Fletcher, Sophie, Flett, Fiona, Flewitt, Karen, Flockhart, Sarah, Flood, Christopher, Floodgate, Ian, Flor, Jonathan, Florence, Vincent, Flowerdew, Mary, Floyd, Sharon, Flynn, Margaret J, Flynn, Rachel, Foden, Claire, Fofana, Adama, Fogarty, Georgina, Foley, Paul, Folkes, Linda, Fong, Tracey, Font, Daniela M, Foo, Aiwyne, Foo, Jane, Foot, Andrew, Foot, Helen R, Foot, Jayne, Forbes, Jane, Ford, Amber, Ford, Jamie, Fordham, Imogen, Foreman, Jennifer, Forester, Matthew, Forkan, Mohammad, Fornolles, Caroline, Forrest, Adam, Forsey, Ellie, Forsey, Miranda, Forshall, Thomas, Forster, Elliot, Forsyth, Abigail, Forton, Julian, Foster, Conrad, Foster, Emily, Foster, Joseph, Foster, Rachel A, Foster, Tracy, Foulds, Angela, Foulds, Ian, Fowe, Folakemi, Fowkes, Natasha, Fowler, Emily, Fowler, Robert, Fowler, Stephen, Fox, Amy, Fox, Claire, Fox, Heather, Fox, Jonathan, Fox, Laura, Fox, Lauren, Fox, Natalie, Fox, Olivia, Fox, Simon, Foxton, Sarah-Jane, Fraile, Eva, Frake, Rebecca, Francioni, Alex, Francis, Olesya, Francis, Rebecca, Francis, Sarah, Francis-Bacon, Theodora, Frankland, Helen, Franklin, Jessica, Franklin, Siobhan, Fraser, Catherine, Fratila, Andi, Frayling, Sharon, Fredlund, Martyn, Freeman, Anna, Freeman, Carol, Freeman, Elaine, Freeman, Hannah, Freeman, Nicola, Freer, Clare, French, Eleanor, French, Thomas, Freshwater, Karen, Frise, Matthew, Fromson, Renate, Frosh, Adam, Frost, John, Frost, Victoria, Froud, Oliver, Frowd, Rachel, Fryatt, Arun, Frygier, Andrzej, Fuller, Bridget, Fuller, Liz, Fuller, Lucy, Fuller, Tracy, Fullerton, Duncan, Fung, Carrie, Fung, Gayle, Funnell, Sarah, Furness, John, Fyfe, Andrew, G, Nytianandan, Gabbitas, Elizabeth, Gabriel, Claire, Gabriel, Zoë, Gachi, Hadiza, Gaffarena, Sophie, Gage, Sarah, Gahir, Joshua, Gajebasia, Sarveen, Gajewska-Knapik, Katarzyna, Gajmer, Babita, Galani, Zacharoula, Gale, Christopher, Gale, Hugo, Gale, Linda, Gale, Rebecca, Gali, Swetha, Gallagher, Bernadette, Gallagher, Jude, Gallagher, Rosie, Gallagher, William, Gallam, Feroze, Galliford, Joanne, Galloway, Catherine, Galloway, Chris, Galloway, Emma, Galloway, Jacqui, Galloway, James, Galvin, Anna, Galvis, Victoria, Gamble, Gareth, Gamble, Laura, Gamble, Liz, Gammon, Brian, Gan, Chien N, Ganaie, Muhammad B, Ganapathi, Jaikumar, Ganapathy, Ramesh, Gandhi, Kaminiben, Gandhi, Sarah, Ganesh, Usha, Ganeshanathan, Thenugan, Ganguly, Saibal, Gani, Abrar, Ganley, Pauline, Garcia, Ukraina, Garden, Emma-James, Gardener, Antoni D, Gardiner, Emma, Gardiner, Michael, Gardiner, Phil, Gardiner, Siobhan, Gardiner-Hill, Caroline, Gardner, Jonathan, Gardner, Louis, Garfield, Mark, Garg, Atul, Garg, Isha, Garlick, Nathan, Garner, Daniel, Garner, Justin, Garner, Lucie, Garner, Zoe, Garr, Rosaline, Garrero, Kathryn A, Gartaula, Manisha, Garty, Florence, Gascoyne, Rachel, Gashau, Hyeriju, Gatenby, Aoife, Gaughan, Erin, Gaurav, Alok, Gavrila, Mariana, Gaylard, Jane, Gayle, Sophie, Geddie, Catherine, Gedge, Ian, Gee, Sarah, Geele, Fartuun, Geerthan, Kalaichelvi, Gellamucho, Minnie, Gelly, Karzan, Gelmon, Leila, Gelves-Zapata, Sandra, Genato, Gemma, Gent, Neal, Gent, Susan, Geoghegan, Natalie, George, Aparna, George, Bini, George, Sam, George, Susan, George, Tina, George, Valerie P, Georges, Simon, Georgiou, Domonique, Gerard, Peter, Gerdes, Leigh, Germain, Louise, Gerrish, Helen, Getachew, Abel, Gethin, Louise, Gettings, Siobhan, Ghanayem, Hisham, Ghavami Kia, 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Bengtsson, Jan, Glowski, Deborah, Glynn, Sharon, Gnanalingam, Chevanthy, Goddard, Julie, Goddard, Wendy, Godden, Emily, Godden, Jo, Godlee, Sarah, Godson, Emma, Godwin, Gillian, Gogoi, Sukanya, Goh, Aiky, Gohel, Manjinder, Goiriz, Rebeca, Gokaraju, Sriya, Goldacre, Raphael, Goldsmith, Arthur, Goldsmith, Portia, Gomersall, Darren, Gomez, Lucia, Gomez-Marcos, Raquel, Gondal, Ali, Gonzalez, Celia, Goodall, Jack, Goodall, Vicky, Goodenough, Bob, Goodfellow, Anna, Goodfellow, Laura, Goodlife, James, Goodwin, Camelia, Goodwin, Elizabeth, Goodwin, Jayne, Goodyear, Paula, Gooentilleke, Rajiv, Goonasekara, Michelle, Gooseman, Sheila, Gopal, Shameer, Gordon, Chris, Gordon, Sally, Gore, Robin, Gorick, Hugh, Gorman, Caitlin, Gorman, Claire, Gormely, Stuart, Gorniok, Maria, Gorog, Diana, Gorst, Michelle, Gorsuch, Thomas, Gosai, Jayshreebahen, Gosling, Rebecca, Gosling, Sally, Gosney, Georgina, Goss, Vanessa, Gotham, Dzintars, Gott, Naomi, Goudie, Elizabeth, Gould, Nicole, Gould, Susan, Goumalatsou, 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Ruth, Hartley, Tom, Hartrey, William, Hartridge, Phillipa, Hartshorn, Stuart, Harvey, Alice, Harvey, Angela, Harvey, Anna, Harvey, Max, Harwood, Catherine, Harwood, Helen, Harzeli, Zoe, Haselden, Brigitte, Hashem, Kazi, Hashimm, Mohammed, Hashimoto, Tadaaki, Hashmi, Imranullah, Haslam, Jack, Haslam, Zena, Hasnip, Grace, Hassan, Adil, Hassan, Ali, Hassan, Amro, Hassan, Awab, Hassan, Zeinab, Hassasing, Sapna, Hassell, Jane, Hassell, Philip, Hastings, Alex, Hastings, Bethany, Hastings, Janice, Hathaway-Lees, Sarah, Hatton, Jonathan, Hau, Jennifer, Havinden-Williams, May, Havlik, Stefan, Hawcutt, Daniel B, Hawes, Kadean, Hawes, Liz, Hawes, Nicola, Hawker, Lydia, Hawkins, Annie, Hawkins, Joe, Hawkins, Nancy, Hawkins, W John, Hawley, Dan, Hawley-Jones, Ed, Haworth, Edward, Hay, Alasdair W, Hay, Cathy, Hayat, Amna, Hayat, Jamal, Hayathu, Mohamed-Riyal, Hayes, Anne, Hayes, Jonas, Hayes, Kate, Hayes, Melony, Hayes, Fiona, Hayle, Patrick, Haylett, Chloe, Hayman, Antara, Hayman, Melanie, Haynes, 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Hetherington, Emily, Hetherington, Joseph, Hettiarachchi, Chamila, Hettiarachchi, Pramodh, Hewer, Hayley, Hewertson, John, Hewetson, Anna, Hewins, Sue, Hewitson, Nicola, Hewitt, Claire, Hewitt, Davina, Hewitt, Richard, Hey, Samuel, Heyderman, Robert S, Heydtmann, Mathis, Heys, Joseph, Heywood, Jonathan, Hibbert, Meg, Hickey, John, Hickey, Naomi, Hickey, Peter, Hickman, Nicky, Hicks, Alex, Hicks, Jenny, Hicks, Scott R, Hien, Phan Thi Thu, Higbee, Daniel, Higgins, Lucy, Higham, Andrew, Highcock, Martin, Highgate, Judith, Hikmat, Mondy, Hill, Amanda, Hill, Helen, Hill, Joanne, Hill, Lisa, Hill, Lucy, Hill, Phoebe, Hill, Uta, Hilldrith, Annette, Hillman-Cooper, Catherine, Hilton, Jon, Hilton, Zoe, Hinch, Sarah, Hindle, Andrew, Hindley, Esther, Hindmarsh, Alice, Hine, Paul, Hinshaw, Kim, Hird, Clare, Hirst, Claire, Hirst, Lindsay, Hives, Jemma, Hlaing, Htet M, Ho, Benson, Ho, David K K, Ho, Rosemary, Hoare, Michaela, Hobden, David, Hobden, Gill, Hobrok, Maria, Hobson, Simon, Hodge, Christopher, Hodge, Simon, Hodgen, Lesley, Hodgetts, George, Hodgkins, Holly, Hodgkinson, Sally, Hodgson, David, Hodgson, Helen, Hodgson, Luke, Hodgson, Sheila, Hodkinson, Gemma, Hodson, Kenneth, Hodson, Mike, Hogan, Alison, Hogben, Matthew, Hogg, Lucy, Hoggett, Lee, Holborow, Abigail, Holbrook, Catherine, Holbrook, Rebecca, Holden, Catherine, Holden, Jill, Holden, Melinda, Holden, Sophie, Holder, Thomas, Holdhof, Niels, Holdsworth, Hannah, Holland, Lisa, Holland, Maureen, Holland, Nicky, Holland, Poppy, Holland, Susan, Hollands, Marie L, Holliday, Elizabeth, Holliday, Kyra, Holliday, Mark, Holling, Nina, Hollos, Laszlo, Hollos, Nora, Holloway, Leah, Holloway, Simon, Hollowday, Max, Hollyer, Marcus, Holman, Amy, Holmes, Ann, Holmes, Megan, Holmes, Raphael, Holmes, Rebecca, Holroyd, Kelly, Holroyd-Hind, Beth, Holt, Lyndsey, Holt, Siobhan, Holt, Susie, Holyome, Alexandra, Home, Marie, Homewood, Renate, Hong, Kate, Hoole, Louise, Hooper, Clare, Hope, Samantha, Hope, Susan, Hopkins, Bridget, Horby, Peter W, Horler, Stephanie, Hormis, Anil, Hornan, Daniel, Hornby, Nicola, Horne, Thomas, Horne, Zoey, Horner, Rebecca, Horrobin, Caroline, Horsford, Latoya, Horsford, Megan, Horsford, Mark, Horsham, Valana, Horsley, Alexander, Horsley, Ashley, Horsley, Elizabeth, Horton, Sarah, Hosea, Jane, Hoskins, Toby, Hossain, Muhammad S, Hossain, Rashed, Hough, Maxine, Hough, Sarah, Houghton, Catherine, Houghton, Kathryn, Houlihan, Rebecca, Housely, Kay, Houston, Hamish, Hovvels, Roseanna, How, Lee, Howaniec, Laura, Howard, Joanne, Howard, Kate, Howard, Laura, Howard, Linda, Howard, Lucy, Howard, Megan, Howard, Sarah, Howard, Stuart, Howard-Griffin, Richard, Howard-Sandy, Louise, Howe, Serena, Howell, Alice, Howells, Mark, Howie, Lyn, Howlett, Kerry, Howlett, Sophie, Howman, Ruth, Hrycaiczuk, Josh, Htet, Hein, Htoon, Naing Z, Htwe, Su, Hu, Ying, Huah, Chiang O H, Huang, Sylvia, Hubbard, Kelly, Huckle, Abby, Huda, Shahzya, Hudak, Alison, Hudig, Lisa, Hudson, Heather, Hudson, Suzanne, Hudson, Oli, Hufton, Alison, Huggins, Connor, Hughes, Alistair, Hughes, Caitlin, Hughes, Emma, Hughes, Gareth, Hughes, Heather, Hughes, Luke, Hughes, Martin, Hughes, Rachel, Hughes, Rebecca, Hughes, Samantha, Hughes, Stephen, Hughes, Vikki, Hughes, Wesley, Huhn, Lukas, Hui, Ching, Hulbert, Ruth, Hull, Diana, Hull, Grace, Hull, Robert, Hulme, Amanda, Hulme, Peter, Hulse, Wendy, Hulston, George, Hum, Ryan, Hume, Megan, Humphrey, Charlotte, Humphries, Alasdair, Humphries, Amy, Humphries, Joanne, Hunt, Charlotte, Hunt, Fiona, Hunt, Jane, Hunt, Jonquil, Hunt, Kristen, Hunt, Luke, Hunt, Molly, Hunt, Sophie, Hunter, Alexandra, Hunter, Catherine, Hunter, Ewan, Hunter, Karl, Hunter, Neil, Hunter, Ross, Hunter, Sophie, Huntington, George, Huq, Fuad, Hurditch, Elizabeth, Hurdman, Judith, Hurley, Cian, Hurley, Katrina, Husain, Mohammed A, Husaini, Syeda Y, Huson, Coralie, Hussain, Afreen, Hussain, Chreif, Hussain, Ibraar, Hussain, Ifza, Hussain, Mohammad, Hussain, Mohammed, Hussain, Muhammad, Hussain, Reda, Hussain, Rizwana, Hussain, Samia, Hussain, Sanniah, Hussain, Yasmin, Hussam El-Din, Mohammed, Hussein, Samahir F E M, Hussein, Ziad, Hussey, Rebecca, Hussien, Adiel Haqiq, Hutchinson, Anja, Hutchinson, Camille, Hutchinson, Dorothy, Hutchinson, Elizabeth, Hutchinson, John, Hutsby, Claire, Hutton, Paula, Huy, Nguyen Quang, Huyen, Thuong, Huyen, Tran Bang, Huyen Thuong, Nguyen Thi, Huynh, Hieu, Hydes, Daniella, Hyde-Wyatt, Jamie, Hynes, Niamh, Hyslop, Megan, Iakovou, Angeliki, Ibison, Katherine, Ibraheim, Mazen, Ibrahim, Abdalla, Ibrahim, Ahmed, Ibrahim, Asil, Ibrahim, Javed, Ibrahim, Mamoun, Ibrahim, Mohamed, Ibrahim, Wadah, Icke, Becky, Idowu, Adetokunbo Idowu, Idrees, Muhammad, Idrees, Nauman, Iftikhar, Hina, Iftikhar, Mawara, Igwe, Chukwuemeka, Igwe, Ogechukwu, Ijaz, Mohammad, Ikomi, Amaju, Iles, Clare, Iliodromiti, Stamatina, Ilsley, Mary, Ilves, Lorna, Ilyas, Fatima Mariam, Imam-Gutierrez, La'ali, Iman, Mohamed, Imray, Christopher, Imtiaz, Haider, Ingham, 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Jones, Tracey, Jonnalagadda, Ramya, Jordache, Rebecca, Jordan, Michele, Jordan, Sarah, Jose, Abi, Jose, Litty, Jose, Louise, Jose, Sanal, Joseph, Anna, Joseph, Gigee, Joseph, P Aiden, Joseph, Rosane, Joseph, Sibet, Joshi, Dhaara, Joshi, Mehul, Joshi, Pratichi, Joshi, Tushar, Josiah, Benz, Joy, Lijo, Joyce, Tiffany, Ju, Hong, Ju Wen Kwek, Adriel, Judd, Andrew, Jude, Edward, Judge, Parminder, Juhl, Jessica, Jujjavarapu, Sirisha, Juniper, Mark, Juszczak, Edmund, Jyothish, Deepthi, Kabiru Dawa, Kasamu, Kacar, Mark, Kadam, Nikhil, Kader, Nicole, Kailey, Ajai, Kain, Matthew, Kakoullis, Gail, Kala Bhushan, Azad, Kalayi, Richard J K, Kaliannan Periyasami, Roobala, Kallistrou, Efthymia, Kalmus Eliasz, Thomas, Kalsoom, Seika, Kam, Elisa, Kamara, John, Kamath, Ajay, Kamath, Prakash, Kamath, Ravindra, Kamerkar, Siddharth A, Kametas, Nick, Kamfose, Musaiwale, Kamundi, Charlotte, Kanabar, Dharmesh, Kane, Leia, Kankam, Osei, Kannan, Thogulava, Kant, Abhinav, Kapil, Vikas, Kapoor, Ritoo, Kapoor, Sonal, Kaprapina, S, Kar, Sourjya, Kara, Janaka, Karbasi, Elshad, Karelia, Shivaali, Kark, Rona, Karkey, Abhilasha, Karki, Aruna, Karmali, Soheilali, Karunanithi, Viji, Karunaratne, Nicholas, Kasianczuk, Natashja, Kasiappan Balasubramanian, Anbhu, Kasipandian, Vidya, Kassam, Rizwan, Kathirgamachelvam, Janarth, Kati, Mpumelelo, Katsande, Victoria, Kaul, Kulbinder, Kaur, Daljit, Kaur, Dervinder, Kaur, Jasmin, Kaur, Jaspreet, Kaur, Simran, Kausar, Zunaira, Kavanagh, Lisa, Kavanagh, susan, Kawser, Mohammad A Al, Kay, Andrea, Kay, Julie, Kay, Robert, Kay, Sarah, Kayappurathu, Jossy N, Kayastha, Srijana, Kaye, Callum, Kazeem, Ahemd, KC, Pooja, Ke, Min, Keady, Timothy, Kearns, Rachel, Kearsley, Nichola, Keating, Joanne, Keating, John, Keating, Liza, Keddie-Gray, Elizabeth, Keegan, Breffni, Keen, Rachel, Keenan, Natalie, Kefas, Jonathan, Kegg, Stephen, Keith, Laura, Keke, Uzoamaka, Kellett, Joanne, Kelliher, Jo, Kelly, Alison, Kelly, David, Kelly, Diane, Kelly, Dominic, Kelly, Emma, Kelly, Hannah, Kelly, Laura, Kelly, Louisa, Kelly, Martin, Kelly, Michael, Kelly, Rosalind, Kelly, Sinead, Kelly, Stephanie, Kelly, Stephen, Kelly-Baxter, Mary, Kelsall, Olivia, Keltos, Marketa, Kemp, Timothy, Kendall, Emma, Kendall-Smith, Alexandra, Kennard, Sarah, Kennedy, Ann, Kennedy, James, Kennedy, Melanie, Kennedy-Hay, Sophie, Kenny, Julia, Kent, Melanie, Keogan, Lynne, Keough, Alexander, Kernaghan, Dawn, Kerr, A, Kerr, Andrew, Kerrison, Caroline, Kerry, Anthony, Kerslake, Helen, Kerslake, Ian, Kerss, Helen, Keshet-Price, Jocelyn, Kestelyn, Evelyne, Keyte, Georgina, Khadar, Abdul, Khadka, Dipika, Khalid, Ali, Khalid, Hadika, Khalid, Muhammad U, Khalid, Syed, Khalid, Mariha, Khalifa, Tarek, Khalil, Amir, Khalil, Asma, Khalil, Sijjad, Khan, Abubakar, Khan, Ali, Khan, Al-Imran, Khan, Arham, Khan, Asad, Khan, Aurangzeb, Khan, Burhan, Khan, Fatimah, Khan, Kausik, Khan, Malik A, Khan, Marria, Khan, Mehrunnisha, Khan, Mohammad, Khan, Myra, Khan, Nayeem, Khan, Nuzhath, Khan, Omar, Khan, Rabia, Khan, Rahila, Khan, Shabana, Khan, Shahul, Khan, Shoaib, Khan, Tasaduksultan, Khan, Waleed, Khan, Waseem, Khan, Zuhair, Khan Tharin, Mohammad S, Khatana, Usman F, Khatri, Januka, Khatri, Jibran, Khatri, Jyoti, Khatun, Hafiza, Khatun, Taslima, Kheia, Mena, Khera, Jacyntha, Khin, Htet Htet Ei, Khoja, Najaf, Khokhar, Kiran, Khong, Minh Quang, Khoo, Joshua, Khurana, Chloe, Kibaru, Joyce, Kibutu, Faith, Kidd, Andrew, Kidd, Michelle, Kidney, Joe, Kidney, Shane, Kieffer, Will, Kilbane, James, Kilby, Caroline, Killen, Eileen, Kilner, Beverley, Kilroy, Susan, Kim, Bomee, Kim, Jee W, Kim, Minhee, Kimber, Aly, Kimber, Sarah, King, Andy, King, Barbara, King, Hayley, King, Jennifer, King, Jenny, King, Kirsten, King, Matthew, King, Rachel, King, Sarah, King, Victoria, King-Oakley, Emily, Kingsmore, Laura, Kinnear, Deborah J, Kinney, Fiona, Kiran, Sidra, Kirby, Alison, Kirk, Adam, Kirk, Jeremy, Kirk, Jill, Kirk, Jodie, Kirkby, Amy, Kirkham, Emily, Kirkman, Gemma, Kirkpatrick, Lucy, Kirwan, Ursula, Kitching, Toby, Kitto, Laura, Kittridge, Lauren, Klaczek, Sarah, Kleemann, Frieder, Kmachia, Susan, Knapp, Christopher P, Knibbs, Lucy, Knight, Alicia, Knight, Fraser, Knight, Marian, Knight, Sarah, Knight, Steven, Knight, Tom, Knights, Ellen, Knights, Jane, Knolle, Martin, Knopp, Paul, Knowles, Charlotte, Knowles, Karen, Knowles, Laurence, Knox, Emily, Knox, Lucy, Koch, Oliver, Kocsor, Marta, Kodituwakku, Ronan, Koduri, Gouri, Koe, Yuan J, Koirala, Janak, Koirata, Aisha, Kolakaluri, Eirene, Kolodziej, Magdalena, Kolokouri, Eirini, Kon, Samantha, Konar, Niladri, Kononen, Mari, Konstantinidis, Athanasios, Kontogonis, Rachel, Koo, Hui Fen, Koopmans, Imogen, Kopyj, Emmanuela, Korcierz, Laura, Korolewicz, James, Koshy, George, Kosmidis, Chris, Kosztolanyi, Csilla, Kotecha, Jalpa, Kothandaraman, Easwari, Koukou, Katerina, Kountourgioti, Athanasia, Kouranloo, Koushan, Kousar'c, Rukhsana, Kousteni, Margarita, Koutalopoula, Anastasia, Kovac, Maja, Kozak Eskenazia, Alex, Krasauskas, Kestutis, Krishnamurthy, Raghu, Krishnamurthy, Vinodh, Krishnan, Manju, Krishnan, Hari, Krishnapalli, Nagaratna, Krizak, Suzanne, Krueper, Stephen, Krupej, Sean, Krzowski, James, Kubaisi, Ria, Kubisz-Pudelko, Agnieszka, Kuckreja, Shavita, Kudsk-Iversen, Soren, Kudzinskas, Aurimas, Kukadiya, Chirag, Kulkarni, Nainesha, Kumala Dewi, Susantika, Kuma-Mintah, Marian, Kumar, Aditi, Kumar, Ayesha, Kumar, Mayur, Kumar, Ramesh, Kumar, Ravi, Kumar, Rita, Kumar, Rupa, Kumar, Satish, Kumar, Vikas, Kumar, Vimal, Kundu, Arun, Kunst, Heinke, Kunwar, Shaibya Singh, Kupiec, Klaudia, Kurani, Amit, Kurdy, Mohammed, Kuriakose, Kevin, Kurian, Rincy, Kurmars, Vimal, Kuronen-Stewart, Cameron, Kusangaya, Ranganai S, Kushakovsky, Vlad, Kutera, Anna, Kuverji, Apexa, Kyei-Mensah, Amma, Kyepa, Henriette, Kyere-Diabour, Thyra, Kyi, Moe, Kyi, Nyan M, Kyle, Laura, Kyriaki, Karali-Tsilimpari, Labao, Julius, Lacey, Louise, Lack, Nikki, Lacson, Maria, Ladan, Zahra, Ladlow, Emma, Lafferty, Heather, Lagnado, Alice, Laha, Shondipon, Lahane, Sushil, Lai, Clement, Lai, James, Laidler, Paula, Laing, Robert, Laing-Faiers, Inez, Laity, Emily, Lake, Katharine, Lakeman, Nicki, Lalloo, David, Lalloo, Fiona, Lam, Alison, Lam, Classy, Lamb, Fiona, Lamb, Lucy, Lamb, Thomas, Lambert, Oscar, Lambert, Pauline, Lameirinhas, Claudia, Lami, Mohammed K G, Lamont, Holly, Lamparski, Michal, Lamrani, Djillali, Lanaghan, Christine, Lancona-Malcolm, Ivone, Landers, Geraldine, Landray, Martin J, Lane, Matthew, Lane, Nicholas, Lang, Alidih, Lang, Stephen, Langer, Daniel, Langley, Margaret, Langoya, Charles, Langridge, Emma, Langthorne, Emily, Langton, Helen, Lara, Beatriz, Large, Taiya, Lartey, Lawrencia Naadu, Lassa, Samuel, Last, Anna, Latham, Scott, Latham, Victoria, Latheef, Afzal, Latif, Larissa, Latt, Nang, Lau, Carmen, Lau, Dawn, Lau, Eva, Laura, Gonzalez G, Laurenson, Myra, Lavington, Eloise, Law, Hou, Law, Jessica, Law, June, Law, Kar Y, Law, Penny, Law, Richard, Lawless, Laura, Lawrence, Chris, Lawrence, Emma, Lawrence, Geoffrey, Lawrence, Holly M, Lawrence, Neil, Lawrie, Ryan, Lawson, Louise, Lawson, Natalie, Lawson, Rod, Lay, Michael, Laybourne, Stephen, Laycock, Christine, Layug, Reina, Lazo, Maria, Le, Thi Thao, Le, Vietland, Lea, Amelia, Lea, William, Leach, Louisa E, Leadbitter, Ian, Leahy, Thomas, Lean, Richard, Leandro, Lorna, Leaning, Darren, Leary, Ruth, Leason, Sandra, Ledingham, Marie A, Lee, Caroline, Lee, Emma, Lee, Hannah, Lee, Irish, Lee, Joshua, Lee, Judith, Lee, Sam, Lee, Shannon, Lee, Shi Han, Lee, Simon, Lee, Sindy, Lee, Stephanie, Lee, Tracey, Lee, Xiang, Lee, Robyn, Lees, Diana, Lees, Jennifer, Legge, Helen, Leggett, Julian, Leigh-Ellis, Katie, Leitch, David, Leitch, Nicky, Lekoudis, Eleni, Lemessy, Petula, Lemoine, Nicholas, Lenagh, Rebecca, Leng, Katy, Lennon, Katrina, Lennon, Liz, Leonard, Beth, Leonard, Kelly, Leong, Wen, Leopold, Nicky, Lepiarczyk, Oskar, Leslie, Isla, Lestari, Eva Noviani, Lester, Eleni, Levell, Emma, Levett, Chris, Levynska, Anastasia, Lewin, Alice, Lewis, Alison, Lewis, Christopher, Lewis, David, Lewis, Dee, Lewis, Heather, Lewis, Joanne, Lewis, Joseph, Lewis, Kathryn, Lewis, Keir, Lewis, Leon, Lewis, Mandy, Lewis, Marissa, Lewis, Nicolas, Lewis, Robert, Lewis-Clarke, Catherine, Lewszuk, Adam, Lewthwaite, Penny, Ley, Samantha, Liao, Angela, Licence, Victoria, Lieberman, David, Liebeschuetz, Susan, Light, Teresa, Lightfoot, Nicky, Lillie, Patrick, Lillis, Ashling, Lim, Ben, Lim, Carys, Lim, Ee T, Lim, Ivy, Lim, Terence, Lim, Wei Shen, Lim, Wilson, Limb, James, Limbu, Dipraj, Limbu, Usha, Linares, Christian, Linden, Dermot, Lindergard, Gabriella, Lindley, Kate, Lindsay, Charlotte, Lindsay, Emily, Lindsay, Max, Lindsay- Clarke, Helen, Ling, Mirella, Lingam, Claire, Linkson, Linette, Linn, Thinzar, Linney, Mike, Lippold, Conrad, Lipscomb, George, Lipscomb, Karen, Lipskis, Laura, Lisboa, Ana, Lister, Evangeline, Little, Jeff, Little, Sam, Littlejohn, Lucy, Liu, Sky, Liu, Xuedi, Llanera, Daniel K, Llewellyn, Rhiannon, Llewelyn, Martin, Lloyd, Adam, Lloyd, Aimee, Lloyd, Arwel, Lloyd, Oliver, Lloyd, Richard, Lo, Su, Loader, David, Loan, Caroline, Lobosco, Livia, Lock, Lydianne, Lock, Sara, Lock, Stephen, Locke, Angela, Locke, Jacqueline, Locke, Thomas, Locke, Jacqueline, Lockett, Teresa, Lodge, Jeorghino, Lodhia, Krishan, Lofthouse, Martina, Loftus, Heather, Logan, Meg, Logue, Chloe A, Loh, Sook Yin, Lokanathan, Siddharth, Lomme, Kaatje, London, Emily, Long, Gabriella, Long, Natalie, Longbottom, Katherine, Longhurst, Bev, Longshaw, Mark, Longstaffe, Sarah, Lonnen, Jennifer, Lonsdale, Caroline, Looby, Laura, Loosley, Ronda, Lopes, Liliana, Lopez, Paola, Lopez, Paula, Lord, Robert W, Lord, Stephen, Lorimer, Claire, Loro, Francesco, Lorusso, Rachel, Loughlin, Catherine, Lovegrove, Wayne, Loveless, Robert, Lovell, Maxine, Loverdou, Angeliki, Low, Andrew, Low, Jen Mae, Low, Shona, Lowe, Alastair, Lowe, Catherine, Lowe, Emily, Lowe, Faye, Lowe, Leanne, Lowe, Michael, Lowsby, Richard, Lowthorpe, Vicki, Lubimbi, Gamu, Lubina Solomon, Alexandra, Lucas, Georgia, Lucas, Jacob, Lucey, Alice, Lucey, Olivia, Luck, Suzanne, Lui, Lok Hin, Luintel, Akish, Luke, H, Luke, Jane, Lungu, Naomi, Lunia, Apurva, Lunn, Muriel, Luo, Ji, Luscombe, Mark, Luveta, Jocelyn, Luximon, Cindy N, Lwin, Khine, Lwin, Myat, Lye, Alison, Lyell, Barrie, Lyka, Elisavet, Lynas, Audrey, Lynch, Ceri, Lynch, Daniel, Lynch, Daniella, Lynch, Stephen, Maamari, Rea-Grace, Mabb, Hannah, Mabelin, Louies, Mabeza, George, Macaro, Jessica, Macconaill, Kateryna, Macdonald, Chloe, Macduff, Andrew, Macfadyen, Claire, Macfarlane, James G, Macfarlane, Jill, Macfarlane, Laura, Macharia, Irene, MacInnes, Lisa, MacIntyre, Iain, MacIntyre, Jill, Mack, Kirsten, Mackay, Callum, Mackay, Euan, Mackay, Laura, Mackenzie, Alexander, Mackenzie, Matt, MacKenzie Ross, Robert, Mackey, Ami, Mackie, Fiona, Mackie, Jennifer, Mackie, Robert, Mackinlay, Carolyn, Mackintosh, Claire, Mackintosh, Katherine, MacLeod, Mary J, Macleod, Shona, Macmahon, Michael, MacNair, Andrew, Macphee, Catherine, Macpherson, Iain, Macrae, Catriona, MacRaild, Allan, Madani, Yasser, Madden, Alannah, Madden, Mary, Madden-McKee, Christopher, Maddison, Sally, Madeja, Norman, Madhivathanan, Pradeep, Madhusudhana, Madhavi, Madu, Alpha, Madziva, Lorraine, Mafham, Marion, Magee, Nick, Magezi, Frederick, Maghsoodi, Negar, Magier, Christopher, Magnaye, Lessica M, Magriplis, Marios, Magtalas, Michelle, Mahabir, Natasha, Mahadevan-Bava, Subramanian, Maharajh, Amitaa, Maharajh, Anjanie, Maharjan, Kijan, Maharjan, Madan, Mahaveer, Ajit, Mahay, Bal, Mahay, Kanta, Mahdi, Amy, Mahdi, Hibo, Mahdi, Noor, Mahendiran, Thushika, Mahendran, Siva, Maher, Sarah, Maheswaran, Anistta, Maheswaran, Shameera, Maheswaran, Tina, Mahjoob-Afag, Parisa, Mahmood, Ahmed, Mahmood, Farhana, Mahmood, Hussain, Mahmood, Waheed, Mahmood, Zahra, Mahmoud, Hager, Mahmud, Mohammed, Mahony, Ewan, Mahungu, Tabitha, Maiga, Oumou, Mair, Luke, Majekdunmi, Toluwani, Majid, Kesson, Major, Amy, Major, Rupert, Majumdar, Jaydip, Majumder, Mohammad K H, Mak, Tsz L A, Makan, Annabel, Makanju, Esther, Makin, Stephen, Makinde, Wura-Ola, Makkeyah, Yahya, Malanca, Marius, Malcolm, Hannah, Malein, Flora, Malhan, Neeraj, Malicka, Agnieszka, Malik, Ayesha, Malik, Gulshan, Maljk, Mohammed, Mallett, Paul, Mallinder, Petrina, Mallison, Georgia, Mallon, Louise, Malone, Edward, Maloney, Gracie, Mamman, Madhu, Man, Irene, Man, Kathy, Mancinelli, Rossana, Mancuso-Marcello, Marco, Mandal, Shrawan K, Mandal, Sudeshna, Manders, Tracy, Manderson, Lauren, Mandeville, Justin, Mane, Tara, Manhas, Roope, Maniero, Carmen, Manikonda, Ravi, Manjra, Ilham, Mankiewitz, Rowan, Mann, Bobby, Manning, Jonathan, Manning, Sarah, Mannion, Pascoe, Mansi, Katherine, Manso, Katarina, Mansour, Dina, Mansour, Mohamed, Mansour, Ramy, Mapfunde, Isheunesu T, Mappa, Predeesh, Maqsood, Arrusaw, Maraj, Hemant, Marchand, Clare, Marcus, Neil, Marcyniuk, Anna, Marecka, Maria, Maren, Deborah, Margabanthu, Gomathi, Margalef, Jordi, Margarit, Lavinia, Margaritopoulos, Georgios, Margarson, Mike, Maria del Rocio, Fernandez, Maria Pfyl, Teresa, Mariano, Victor, Maric, Ashleigh, Markham, Grace, Marks, Ben, Marks, Maria, Marks, P, Marler, Emily, Marouzet, Elisabeth, Marriott, Arran, Marriott, Cheryl, Marriott, Nemonie, Marsden, Christopher, Marsden, Karen, Marsden, Paul, Marsden, Sarah, Marsden, Tracy, Marsh, Cathryn, Marsh, Glen, Marsh, Robyn, Marshall, Adam, Marshall, Andrew, Marshall, Gail, Marshall, Henry, Marshall, Jaimie, Marshall, Jenna, Marshall, Nicola, Marshall, Riley, Marshall, Steven, Marshall, Jennifer, Martin, Emmeline, Martin, Gaynor, Martin, Hayley, Martin, Hope, Martin, Jane, Martin, Karen, Martin, Kate, Martin, Laila, Martin, Martha, Martin, Michael, Martin, Noelia, Martin, Tim, Martin, Winston, Martin, Sarah, Martindale, Tim, Martineau, Marcus, Martinez, Lauren, Martinez Garrido, Jose C, Martin-Lazaro, Juan, Maruthamuthu, Vijay K, Marwan, Bukhari, Maryan, Gemma, Mary-Genetu, Roman, Maryosh, Sam, Masani, Vidan, Mascagni, Allison, Maseda, Diego, Maseko, Zandile, Mashate, Sheila, Mashhoudi, Yasaman, Mashta, Al, Masih, Izhaq, Masih, Sanna, Maskell, Nicholas, Maskell, Perry, Maskey, Prabina, Masoli, Matthew, Mason, Julia, Mason, Rebecca, Mason, Richard, Mason, Ruth, Mason, Claire, Masood, Mohammad, Masood, Mohammad T, Masood, Syed S M E, Massa, Thalia, Massey, Ian, Masters, Joseph, Masud, Aaqib, Matapure, Lear, Matei, Cristina, Matewe, Ropafadzo, Matey, Esther, Matharu, Manraj, Mathen, Stephy, Mather, Alex, Mather, Nicole, Mathers, Jonathan, Matheson, Joanna, Mathew, Amal, Mathew, Anna, Mathew, Bijoy, Mathew, Moncy, Mathew, Verghese, Mathews, Jesha, Mathias, Kate, Mathioudakis, Alexander, Matila, Darwin, Matimba-Mupaya, Wadzanai, Matin, Nashaba, Matisa, Elina, Matkins, Ellen, Matonhodze, Max, Matovu, Elijah, Mattappillil, Jaysankar, Matthews, Alison J, Matthews, Clive, Matthews, Heather, Matthews, Helen, Mattocks, Lehentha, Maughan, Charlotte, Maulidya, Tara Titian, Mawson, Emma, Maxton, Fiona, Maxwell, Adam, Maxwell, Veronica, May, Emily, May, James, May, Joanne, May, Philippa, Mayanagao, Irving, Maycock, Matthew, Mayer, Jordan, Mayers, Graham, Maynard, Victoria A, Mayo, Thomas, Mayola, Lioniza, Mayor, Shelley, Mazen, Ibreaheim, Mazhani, Thamani, Mazzella, Andrea, Mburu, Nyambura, Mbuyisha, Angeline, Mc Cague, Celine, McAleese, Eleanor, McAlinden, Paul, McAllister, Lesley, McAlpine, Audrey, McAlpine, Graeme, McAndrew, Jonathan, McAuley, Hamish, McAuliffe, Sarah, McBrearty, Claire, McBride, Erin, McBuigan, Michael, McBurney, James, McCabe, Laura, McCafferty, Gemma L, McCafferty, Laura, McCairn, Amanda, McCammon, Jake, McCammon, Nicole, McCann, Conor, McCann, Erin, McCarrick, Alexandra, McCarron, Brendan, McCarthy, Eoghan, McCarthy, Michelle, McCarthy, Natalie, McCaughey, Sinead, McClay, Tara, McClelland, Beverley, McClintock, Declan, McCloskey, Michael, McCollum, Kirsten, McCorkindale, Alasdair, McCormack, Patricia, McCormick, Jacqueline, McCormick, Jake, McCormick, Wendy, McCourt, Paul, McCrae, Jame, McCready, Sharon, McCreath, Gordan, McCreedy, Helen, McCue, Claire, McCullagh, Iain J, McCullagh, Liz, McCullagh, Megan, McCullough, Conor, McCullough, Katherine, McCullough, Nicola, McCullough, Sarah, McCurrach, Fiona, McDermott, John, McDermott, Paula, McDermott, Rory, McDevitt, Katharine, McDill, Helen, McDonald, Basil, McDonald, Carly, McDonald, Claire, McDonald, Debbie, McDonald, Rob, McDonald, Sam, McDonald, Damhnaic, McDonnell, Natasha, McDougall, Catherine, McDougall, Lilly, McDougall, Rowan, McEleavy, Irene, McElwaine, Fred, McEntee, Julie, McEvoy, Evanna, McEwan, Claire, McEwen, Ruth, McFadden, Margaret, McFarland, Denise, McFarland, Margaret, McFarland, Rachel, McFlynn, Joe, McGarry, Erin, McGarvey, Lorcan, McGeachan, Alex, McGee, Frederick, McGenily, Laura, McGettigan, Clodagh, McGettrick, Michael, McGhee, Christopher, McGill, Fiona, McGinnity, Sarah, McGlinchey, Neil, McGlone, Phil, McGlynn, Deborah, McGoldrick, Claire, McGoldrick, Clare, McGough, Elizabeth, McGovern, Christopher, McGovern, Roisin, McGowan, Angela, McGown, Anne, McGrath, Brendan, McGregor, Amanda, McGregor, Annemarie, McGuigan, Michael P, McGuinness, Heather, McGuire, Sean, McHugh, Tara, McInnes, Caroline, McInnes, Neil, McIntosh, Jerome, McIntyre, Karen, McIntyre, Mhairi, McKay, Lorna, McKeag, Conor P, McKeane, Jacqueline, McKee, Madeleine, McKeever, Joseph, McKenna, Judith, McKenna, Shirley, McKenzie, Mary, McKeogh, Donogh, McKerr, Caroline, McKie, Anthony M, Mckie, Hayley, Mckie, Laura, McKnight, Gerard, McLachlan, Heather, McLaren, Andrew, McLaren, Barbara, McLarty, Nicola, Mclaughlan, Danielle, McLaughlin, Maria, McLay, James, McLeish, Mary, McLennan, Tina, McLure, Stewart, McMahon, Anne Marie, McMahon, Genevieve, McMahon, Mike, McMahon, Stephen, McManus, Terence, McMaster, Moyra, McMaster, P, McMaster, Paddy, Mcmeeken, Faye, McMeekin, Samuel, McMillan, Nicola, McMillen, Katherine, McMinn, Jason, McMorrow, Liam, McMullen, Heather, McMurran, Christopher, McNally, Helen, McNeela, Fiona, McNeil, Lynne, McNeill, Claire, McNeill, Jessica, McNeill, Shea, McNelis, Una, McNulty, Melanie, McNulty, Roisin, McParland, Christopher, McPhail, Mark, McQueen, Alison, McSkeane, Anna, McSorland, Denise, McSorley, Therese, McTaggart, Gini, McTaggart, Jacqueline, Mead, Joanna, Mead, Paul, Meadows, Emma, Meakin, Olivia, Mearns, Ben, Mearns, Claire, Mears, Kim, Mears, William, Meda, Manjula, Mediana, Ayren, Medine, Ross, Medveczky, Thomas, Meehan, Sharon, Meeks, Emily, Megan, Abbi, Meghani, Nevan, Meghjee, Salim, Megson, Sharon, Mehar, Amina, Mehmood, Mehr N, Mehra, Rohan, Mehta, Rohan, Meintjes, Graeme, Meirill, James, Meiring, James, Mejri, Rayane, Mekonnen, Ellen, Melander, Sabina, Melinte, Adriana-Stefania, Mellersh, Jennifer, Melling, Lucy, Mellish, Christie, Mellor, Francesca, Mellor, Joe S, Mellor, Samantha, Mellor, Zoe, Mellows, Katrina, Melnic, Vladimir, Melville, Alice, Melville, Dominique, Melville, Julie, Membrey, Helen, Mencias, Mark, Mendelski, Adam, Mendelson, Marc, Mendonca, Cheryl, Meney, Carron, Menezes, Colin, Mensah, Winifred, Mentzer, Alexander, Menzies, Dan, Menzies, Sarah, Mepham, Sue, Mercer, Oliver, Mercer, Pauline, Merchant, Arwa, Merchant, Fatema, Mercioniu, Mihaela, Meredith, Megan, Merida Morillas, Marta, Merrick, Blair, Merritt, Jack, Merritt, Sharon, Merritt, Simon, Merron, Paul-Peter, Merwaha, Ekta, Message, Simon, Messenger, Jenny, Metcalf-Cuenca, Gabriel, Metcalfe, Alexandra, Metcalfe, Benjamin, Metcalfe, Kneale, Metherell, Stella, Metryka, Alexsandra, Mew, Louise, Meyrick, Simon, Mguni, Nhlanhla, Miah, Atiqa, Miah, Jagrul, Miah, Nahima, Mian, Areeb, Mic, Gabriela, Micah-Amuah, Lawrence, Micallef, Dariush, Michael, Alice, Michael, Angiy, Michael, Shery, Michalak, Natalia, Michalca-Mason, Loredana, Michalec, Ola, Middle, Janet, Middleton, Hayley, Middleton, Jennifer T, Middleton, Maeve, Middleton, Sophie, Mieres, Shelley, Mihalca-Mason, Loredana, Mikolasch, Theresia, Milgate, Sarah, Millar, Colin, Millar, Jonathan, Millard, James, Miller, David, Miller, Johnathan, Miller, Lucy, Miller, Rachel, Miller-Biot, Naomi, Miller-Fik, Alex, Millett, Louise, Milligan, Barry, Milligan, Hazel, Milligan, Iain, Milliken, Caitlin, Millington, Katherine, Millington, Rhys, Millington, Samuel, Mills, Helen, Mills, Janet, Mills, Rebecca E, Millward, Helen, Miln, Rebecca, Milne, Alice, Milne, Charlotte, Milne, Louise, Milner, Joanne, Milner, Leanne, Min, Zayar, Mindel, Samuel, Minkah, Prince Amankwah Baffour, Minnis, Chrissie, Minnis, Paul, Minou, Konstantina, Minskip, Natalie, Minton, Jane, Miranda, Frederico, Mirela, Mukaj, Mirza, Taimur, Misbahuddin, Anjum, Mishra, Aseem, Mishra, Biswa, Mishra, Eleanor, Mishra, Ritu, Misra, Sannidhya, Mistry, Deena, Mistry, Heena, Mital, Dushyant, Mitchard, Sarah, Mitchell, Ben, Mitchell, Caroline, Mitchell, Luke J, Mitchell, Piers, Mitchelmore, Philip, Mitra, Andrew, Mitra, Atideb, Mitra, Sandip, Mlambo, Nomsa, Moakes, Emma, Moar, Kirsten, Moatt, Emma, Mock Font, Daniela, Modgil, Gita, Mohamed, Abdelrahman, Mohamed, Arez, Mohamed, Osab, Mohammad, Akram, Mohammad, Waheed, Mohammed, Aliabdulla, Mohammed, Omer, Mohammed, Yaser N S, Mohamud, Bilal A, Moharram, Amr, Mok, Hoi-Ping, Mok, Jonathan, Mokogwu, Leslie, Molina, Marcelino, Moller-Christensen, Christine, Mollet, Mateus, Molloholli, Malid, Molloy, Aoife, Molloy, Linda, Molyneux, Andrew, Molyneux, Rebekah, Momoniat, Tasnim, Monaghan, Holly, Monaghan, Krista, Mongolu, Shiva, Monika, Tesha, Monsell, Katelyn, Montasser, Mahmoud, Montgomery, Alan, Montgomery, Hugh, Moodley, Prebashan, Moody, Margaret, Moody, Nick, Moon, Angela, Moon, James, Moon, Ji-Hye, Moon, Maria, Moonan, May, Moondi, Parvez, Moorby, Suzanne, Moorcroft, Jim, Moore, Alex, Moore, Christopher, Moore, David A J, Moore, Faye, Moore, Judith, Moore, Laura, Moore, Natalie, Moore, Sally, Moore, Siobhan, Moore, Sonia, Moore, Vanessa, Moores, Rachel, Morab, Ed, Morales, Jose, Moramorell, Nuria, Moran, Louise, Moray, Grishma, Moreno-Cuesta, Jeronimo, Morgan, Alexander, Morgan, Amy, Morgan, Caitlin, Morgan, Christine, Morgan, Colin, Morgan, Holly, Morgan, Katie, Morgan, Lauren, Morgan, Leila, Morgan, Lewis, Morgan, Matthew, Morgan, Patrick, Morgan-Jones, Katie, Morgan-Smith, Emily, Morilla, Joseph, Morley, Anna, Morley, Thomas, Morley, Wendy, Morris, Anna, Morris, Damian, Morris, Fiona, Morris, Helen, Morris, Juliet, Morris, Katie, Morris, Laura, Morris, Lucy, Morris, Mary-Anne, Morris, Niall, Morris, Paul, Morris, Sheila, Morris, Susan, Morrison, Douglas, Morrison, Moira, Morrison, Scott, Morrissey, Mary, Morrow, Abbie C, Morrow, Anna, Morselli, Franca, Mortem, Gordon, Mortland, Valerie, Morton, Chelsea, Morton, Gordon, Morzaria, Priti, Mosby, Daniel, Moseley, Linda, Moshal, Karyn, Moshy, Ben, Moss, Alison, Moss, Charlotte, Moss, James, Moss, Sarah, Moss, Stuart, Mostafa, Omar, Moth, Georgia, Motherwell, Nicki, Mottershaw, Sharon, Moudgil, Harmesh, Mouland, Johanna, Moulds, Caroline, Moulton, Hilary, Mounce, Ginny, Mousley, Elizabeth, Mowatt, Chris, Moxham, Karen, Moya, Borja, Moyo, Quberkani, Mshengu, Eunice, Mtuwa, Sheila, Muazzam, Ali, Muazzam, Iqtedar A, Muchenje, Nykki, Mudawi, Dalia, Muddegowda, Girish, Mufti, Rabia, Mugal, Imran, Mughal, Ahsan, Muglu, Javaid, Muhammad, Fawad, Muhammad, Javed, Muir, Carol, Mukherjee, Aparna, Mukherjee, Dipak, Mukhtar, Jameel, Mukhtar, Syed A A, Mukimbiri, Denise, Mulcahy, John, Mulcahy, Michelle, Mulgrew, Peter, Mulhearn, Ben, Mulla, Arafat, Mullan, Dee, Mullasseril Kutten, Dileepkumar, Mullen, Niall, Mullett, Rosemary, Mulligan, Ciara, Mulligan, Sandra, Mumelj, Lana, Mumford, Andrew, Munavvar, Mohammed, Munby, Henry, Munday, Hannah, Munro, Anne-Marie, Munt, Sheila, Mupudzi, McDonald, Murad, Arshid, Muraina, Oluwatosin H, Muralidhara, Koteshwara, Murdoch, Mhairi, Murira, Jennifer, Murphy, Alison, Murphy, Ben, Murphy, Carl, Murphy, Cathal, Murphy, Erin, Murphy, Gail, Murphy, Hannah, Murphy, Peter, Murphy, Rebecca, Murphy, Sheenagh, Murphy, Simon, Murphy, Alison, Murray, Clare, Murray, David, Murray, Dawn, Murray, Eleanor, Murray, Katie, Murray, Kenneth, Murray, Lindy, Murray, Lisa, Murray, Lorna, Murray, Tracey, Murtagh, Eoin, Murthy, Mithun, Murton, Catherine, Murton, Rosie, Muru, Neeka, Musanhu, Rosemary, Mushabe, Maimuna, Mushtaq, Omaisa, Musini, Sohmal, Mustafa, Ahmed M M, Mustafa, Elhaytham, Mustafa, Mustafa, Mustapha, Ibrahim, Mustfa, Naveed, Mustufvi, Zhain, Mutch, Callum, Mutch, Rachel, Mutema, Eric, Muthukrishnan, Balakumar, Mutton, Sheree, Muzengi, Natasha, Mwadeyi, Memory, Mwale, Bettina, Mwaura, Esther, Myagerimath, Raji, Myers, Alice, Myers, Sam, Myerson, James S, Myint, Khin Swe, Myint, Yadee, Mynott, Georgina, Myslivecek, Libor, Nabayego, Patricia, Nadar, Evelyn, Nadeem, Iftikhar, Nadheem, Moosa, Nadjm, Behzad, Naeem, Asma, Naeem, Hassan, Naeem, Salman, Nafees, Samraiz, Nafei, Mohamed, Naftalia, Widya, Nagarajan, Thapas, Naglik, Leah, Nagra, Imrun, Nagra, Deepak, Naguib, Mina, Naguleswaran, Kirushthiga, Nagumantry, K Shonit, Naicker, Kevin, Naidoo, Sarveshni, Naik, Gireesha, Naik, Rishi, Naik, Samir, Nair, Devu S, Nair, Rajiv, Nair, Tanushree, Naisbitt, Jay, Naismith, Kerry, Nakiboneka-Ssenabulya, Deborah, Nallapareddy, Sri, Nallapeta, Soum, Nallasivan, Arumugan, Nam, Ha Xuan, Nanda, Uttam, Nandani, Aarti, Nandwani, Tara, Naqvi, Ali Raza, Naqvi, Asadullah, Naqvi, Sara, Nasa, Sophia, Nash, Dominic, Nasheed, Nader, Nasimudeen, Abdul, Nasir, Umer, Nasronudin, Nasronudin, Nasser, Tahir, Natarajan, Anuja, Natarajan, Geetha, Natarajan, Nalin, Natarajan, Nikhila, Natarajan, Rajkumar, Nath, Preethy, Nathaniel, Noel, Nathvani, Mala, Nathwani, Priyan, Nava, George, Navaneetham, Neena, Navaratnam, Jeya, Navarra, Helen, Naveed, Sadaf, Navin, John, Nawaz, Khuteja, Nawaz, Sarfaraz, Nawaz, Shasta, Nayar, Bonilla, Naylor, Suzanne, Nayyar, Moez, Naz, Farrah, Naz, Mobeena, Nazari, Babak, Nazir, Abida, Nazir, S, Nazir, Sehar, Ncomanzi, Dumisani, Ndefo, Onyinye, Ndoumbe, Narcisse B, Neal, Abigail, Neal, Alan, Neary, Elaine, Negmeldin, Mostafa, Neil, Jonathan, Neill, Paula, Neils, Hector E, Nejad, Avideah, Nel, Jeremy, Nel, Louise, Nelson, Andrew, Nelson, Benjamin, Nelson, Lauren, Nelson, Marie, Nelson, Memory, Nelson, Richard, Nelson, Scott, Nelson, Sven, Nelwan, Erni, Nemane, Rajesh, Nepal, Samiksha, Nethercott, Daniel, Netherton, Kimberley, Nettleton, Kimberley, Neupane, Kabita, Newby, Alison, Newby, Angela, Newby, David, Newcombe, Tracy, Newell, Helen, Newman, Charlotte, Newman, Diana, Newman, Hannah, Newman, Julie, Newman, Oscar, Newman, Tabitha, Newman, Thomas, Newport, Rachel, Newton, Maria, Ng, Anthony Y K C, Ng, Hui En Jewel, Ng, Ka Wing, Ng, Maxine, Ng, Sarah, Ng, Wee Jin, Ng, Yee W M, Ngan, Thomas, Ngo, Thanh Ha, Ngui, Gabriel CE, Ngumo, Alice, Nguyen, Hong Khanh, Nguyen, Minh Thu, Nguyen, Nguyen Thi Thao, Nguyen, Quang, Nguyen, Thi Huyen Trang, Nguyen, Thi Thao, Nguyen, Thi Thao Nguyen, Nguyen, Thi Thuong, Nguyen, Thi Thuy Phuong, Ngwenya, Keith, Nic Fhogartaigh, Caoimhe, Nicholas, Nathalie, Nicholas, Philip, Nicholas, Rachel, Nicholas, Rebecca, Nicholls, Donna, Nicholls, Lisa, Nicholls, Sarah, Nicholson, Alice, Nicholson, Anne, Nicholson, Annette, Nickson, Ian, Nicol, Eileen, Nicol, Elizabeth, Nicol, Rebecca, Nicola, Pantelis, Nicoll, Antony, Nightingale, Tania, Nikita, Faria, Nikolaos, Pantzaris, Nikonovich, Georgii, Nilsson, Annette, Nimako, Kofi, Nimako, Louise, Nimmo, Camus, Ninan, Preethy, Nirmalan, Mahesh, Niroula, Richa, Nisar, Attiya, Nisar, Muhammad, Nisar, Tosia, Nisbett, Toby, Nisha James, Aksinya, Nishat, Sabaahat, Nishiyama, Tomoko, Nix, Sara, Nixon, Jennifer, Nixon, Maxine, Nizam Ud Din, Khwaja, Nizami, Maria, Nizamis, Serafeim, Njafuh, Raymond, Noakes, India, Noba, Lyrics, Noble, Jennifer, Noble, Jonathon, Noble, Harriet, Noe, Hsu M, Nolan, Jerry, Nolasco, Jackson, Noor, Zahid, Noori, Zaid, Norcliffe, Jayne, Norman, Louis, Norman, Rachel, Norris, Emma, Norris, Karen, Norris, Lillian, Nortcliffe, Sally Ann, North, Fiona, North, Julie, North, Thomas, Northfield, John, Northover, Samantha, Nortje, Jurgens, Norton, Donna, Norton, Rowen, Notman, Holly, Nourein, Khalid, Novak, Timea, Novas Duarte, Nuria, Novis, Catherine, Nowak, Justyna A, Nu, Khin Phwe, Nugdallah, Mohamed, Nugent, Anne M, Nugent, Justine, Nugroho, Cahyo Wibisono, Numbere, Numbere, Nundlall, Kribashnie, Nune, Arvind, Nunn, Kieran, Nunn, Michelle, Nunnick, Jane, Nupa, Yvonne, Nur, Fadumo, Nurgat, Zubeir, Nuttall, Amy, Nwafor, Lorenza, Nwajiugo, Paul C, Nyamugunduru, Godfrey, Nyanor, Livina, Nyirenda, Maggie, Nyland, Kerry, O Rinn, Donal, O Shea, Daire, O Toole, Megan, O'Hara, Marianne, O'Hara, Chloe, O'Keefe, Laura, O'Reilly, Kevin, O'Rourke, William, Oakley, Caroline, Oakley, Naomi, Oakley, Susan, Obale, Begho, Oboh, Clements, O'Brien, Clare, O'Brien, Julie, O'Brien, Kirsty, O'Brien, Linda, O'Brien, Neale, O'Brien, Rachel, O'Brien, Tracey, O'Bryan, Emma, Obukofe, Ross, O'Callaghan, Christopher, O'Connell, Lorcan, OConnor, Tadg, O'Connor, Chris, O'Connor, Grainne, Odam, Miranda, Oddie, Sam, Oddy, Sharon, Odedina, Yejide, Odedra, Krishma, Odelberg, Sven W, Odell, Natasha, Oderinde, Omolola, Odone, Jessica, O'Donohoe, Lynn, O'Donovan, Catherine, Odysseos-Beaumont, Isabel, O'Farrell, Stephen, Offord, Pamela, O'Flaherty, Morgan, Ofori, Emmanuel, Ogbara, Tanwa, Ogilvie, Catherine, O'Gorman, Ciaran, Ogunjembola, Ibrahim, Ogunkeye, Oluwatomilola, Ohia, Udeme, Ojha, Shalini, Ojha, Sushma, Ojo, Ohiowele, O'kane, Fiona, O'Kane, Mark, Okeke, Tolu, OKell, Eleanor, Okines, Alicia, Okpala, Iheoma, Okpo, Ernest, Okpoko, F, Okubanjo, Maryanne, Oladipo, Chiamaka, Olaivar, Liel A, Olaiya, Raphael, Olatujoye, Jacob, Old, Tim, Oleszkiewicz, Gregory, Oliver, Annie, Oliver, Catherine, Oliver, Jesse, Oliver, Lucinda, Oliver, Martyn, Oliver, Zoe, Olokoto, Nurudeen O, Olonipile, Folusho, Olufuwa, Olumide, Olukoya, Olatomiwa, Oluwole-Ojo, Akinlolu, O'Malley, Laura, Omane-Donkor, Priscilla Kesewaa, Omar, Maryam, Omar, Mohamad, Omar, Zohra, Omer, Nimca, Omoregie, Eti, O'Neill, Connaire, O'Neill, Lauran, Ong, Chon Sum, Onuoha, Onyinye, Onyeagor, Chidera, Oo, Chan Nyein, Oo, Zin Nwe, Ooi, Huah Chiang, Ooi, Sze Hwei, Oomatia, Amin, Opata, Alfred, Opena, Maria, Oram, Richard, Ord, Christy, Ord, Jonathan, Oreilly, Clare, Orekoya, Lola, O'Riordan, Devaki, O'Riordan, Sean, Orlikowska, Izabela, Orme, Amy, Orme, Hannah, O'Rourke, Laura, Orr, Charlotte, Orr, Sarah, Orton, Christopher, Osadcow, Anna, Osagie, Rawlings, Osanlou, Rostam, Osborne, Lynn, Osborne, Nigel, Osborne, Rebecca, Osborne, Wendy, Osborne, William, Osbourne, Charles, Osei-Bobie, Jennifer, Osman, Joseph, Osman, Wa'el, Osman, Bashir, Osoata, G, Ostermann, Marlies, O'Sullivan, Eoin, O'Sullivan, Susan, Oteng, Mercy Adomah, Otey, Noor, Otite, Otheroro K., O'Toole, Marie, Ouyang, Jingxiu, Owen, Rachel, Owen, Stephanie, Owens, Emma, Owoseni, Yetunde, Owston, Michael, Oxlade, Ruth, Ozdes, Feray, Pack, Jamie, Packham, Alice, Packham, Sophie, Paczko, Piotr, Padden, Grace, Padmakumar, Anand, Page, Catrin, Page, Iain, Page, Joseph, Page, Shannon, Page, Valerie, Paget, Jodi, Pagett, Katherine, Paisley, Lee, Pajak, Susannah, Pajak, Susie, Pakou, Glykeria, Pakozdi, Angela, Pal, Soubhik, Pal, Sushi, Palacios, April, Palagiri Sai, Vishnu B, Palaniappan, Vadivu, Palanivelu, Priya, Palfreeman, Adrian, Palfrey, Heather, Palissery, Vinod, Palit, Deepshikha, Pallipparambil Antony, Sherly, Palman, Jason, Palmer, Alistair, Palmer, Helen, Palmer, Janet, Palmer, Lynne, Palmer, Ross, Pambouka, Andrea, Pamphlett, Ian, Pan, Daniel, Pandey, Anmol, Pandian, Nithya, Pandya, Krishnaa, Pandya, Tej, Paneru, Hem Raj, Panes, Alice, Pang, Jessica, Pang, Yee Wei, Pangeni, Raju, Pannell, Laura, Pannu, Kanwar, Pant, Suman, Panthakalam, Sathianathan, Pantin, Charles T, Pao, Norman, Papaconstantinou, Helen, Papavarnavas, Nectarios Sophocles, Papineni, Padmasayee, Paques, Kitty, Paracha, Abdul W, Paradowski, Kerry, Parambil, Vinay, Paranamana, Supathum, Parashar, Siddhant Raja, Parberry, Ian, Parekh, Amy, Parekh, Dhruv, Parfitt, Louise, Parfrey, Helen, Parikh, Omi, Parish, Gemma, Park, John, Parkash, Vivak, Parker, Angela, Parker, Ben, Parker, Emma, Parker, Helen, Parker, Jacob, Parker, Julie, Parker, Laura, Parker, Lucy, Parker, Natasha, Parker, Nicola, Parker, Sara, Parker, Sean, Parkin, Kirstin, Parkinson, Anna, Parkinson, Molly, Parkinson, Valerie, Parmar, Chetan, Parmar, Viraj, Parris, Victoria, Parrish, Chloe, Parry, Bethan, Parry, Helen C, Parslow-Williams, Siobhan, Parsonage, Maria, Parsons, Georgie, Parsons, Joseph, Parsons, Penny, Partridge, Richard, Parvez, Zeeshan, Parvin, Kevin, Passby, Lauren, Passey, Samuel, Passmore, Heather, Pastrana, Juan, Patachako, Jonathan, Patal, Mital, Patch, Sarah, Patel, Aamie, Patel, Alkesh, Patel, Amisha, Patel, Bijal, Patel, Dakshesh, Patel, Darshna, Patel, Hemani, Patel, Jaymik, Patel, Kamal, Patel, Kayur, Patel, Kiran, Patel, Krish, Patel, Manish, Patel, Margi, Patel, Martyn, Patel, Mehul, Patel, Naleem, Patel, Nehalbhai, Patel, Prital, Patel, Saagar, Patel, Sanjay, Patel, Soonie, Patel, Trishna, Patel, Zaakirah, Patel, Vishal, Paterson, Kirsteen, Pathak, Sangeeta, Pathak, Sunil, Pathan, Nazima, Patience, Alexandra, Patience, Donna, Patmore, Russell, Patole, Sonia, Paton, Lia, Patrick, Abigail, Patrick, Georgie, Patrick, Jean, Patten, Simon, Pattenden, Ben, Patterson, Charlotte, Patterson, Jean, Patterson, Linda, Patterson, Molly, Patterson, Robert, Pattrick, Martin, Paudel, Damodar, Paudel, Kamala, Paudel, Manu, Paudel, Suman, Paul, Moriarty, Paul, Suman, Pauls, Leigh, Paulus, Stephane, Pavely, Amelia, Pavitt, Matthew J, Pavord, Susan, Payne, Brendan, Payne, Elizabeth, Payne, Mark, Payne, Ruth, Peacock, Linda, Peacock, Louise, Peacock, Sarah, Peake, Henry, Pearce, Jasmine, Pearse, Rachel, Pearse, Rupert, Pearson, Andrew, Pearson, Daniel, Pearson, Harriet, Pearson, Karen, Pearson, Samuel A, Pearson, Sandra, Peasley, Alice, Peddie, Hilary, Peebles, Steven, Peek, Russell, Peer, Adam, Peerbhoy, Shahid, Pegg, Claire, Peggie, Eleanor, Peggie, Hannah, Peglar, Suzannah, Peirce, Benjamin H, Peirse, Mary, Pelham, Claire, Pemberton, Abigail, Penacerrada, Melchizedek, Pender, Anthony, Pendlebury, Carmel, Pendlebury, Jessica, Penfold, Rachel, Penman, Catherine, Penman, Julie, Penman, Rachel, Penner, Justin, Penney, Kristi, Pennington, Anna, Penny, James, Pepperell, Justin, Percival, Rachel, Pereira, Adriana, Pereira, Rita, Pereira Dias Alves, Carlota, Perera, Indika, Perera, Marek, Perez, Elena, Perez, Jane, Perinpanathan, Tanaraj, Periyasamy, Lakshmi, Perkins, Emma, Pernicova, Ida, Perritt, Elizabeth, Perry, Alice, Perry, Alison, Perry, Emily, Perry, Meghan, Perumpral, Thomas M, Pessoa-Amorim, Guilherme, Petch, Ruth, Peter, Lionel, Peters, Cecilia, Peters, Lucy, Peters, Mark, Peters, Steve, Peters, Tim, Petersen, Remy, Peterson, Alexandra, Peto, Leon, Petras, Iulia, Petrova, Boyanka, Petrova, Mirela, Petrovics, Ellen, Pettigrew, Tom, Pezard-Snell, Marius, Pfeffer, Paul, Phalod, Gunjan, Pham, Ngoc Thach, Pham, Van Phuc, Phan, Thi Thu Hien, Phanish, Mysore, Phelan, Paul, Philbey, Christopher, Philbin, Jennifer, Phillips, Aled, Phillips, Alex, Phillips, Bethan, Phillips, Dylan, Phillips, Nicola, Phillips, Patrick, Phillips, Rachael, Phillips, Thomas, Phipps, Marie, Phipps, Michael, Phong, Nguyen Thanh, Phongsathorn, Virach, Phull, Mandeep, Phung, Ho Thi Kim, Phuyal, Anita, Phyo, Aye Kyaw, PI, Myat T T, Pick, Sara, Pickard, James, Pickering, Charlotte, Pickering, Frances, Pickering, Gillian, Pickett, Thomas, Pickles, Joanna, Pickstock, Shirley, Pickwell-Smith, Benjamin, Pieniazek, Natalia, Piercy, Charlie, Pieris, Angelo, Pilgrim, Samia, Pillai, Paul Anthony, Pilling, Laura, Pilsworth, Zoe, Pinches, Heather, Pinches, Stacey, Pine, Kirsty, Pinjala, Muni T, Pintus, Stefania, Piper, Graeme, Pirani, Tasneem, Pitchford, Marie, Pittman, Marcus, Pitts, Sally, Plaatjies, Nicolene, Platt, Naomi, Pleass, Robert, Plowright, Megan, Plummer, Laura, Plumptre, Charles, Pobjoy, Jonathan, Pogreban, Tatiana, Poku, Charles, Poku, Stephen, Polgarova, Petra, Pollard, Rachel, Pollock, Louisa, Poluyi, Oluwamayowa, Polwarth, Gary J, Pomery, Fiona, Ponce, Ida M F, Ponnusamy, Ponmurugan, Ponnusamy, Suresh, Ponnuswamy, Aravind, Ponte Bettencourt dos Reis, Inês, Pooboni, Suman, Poole, Alice, Poole, Lynda, Poole, Michele, Poon, Sharon, Poonian, Tajinder, Porteous, Jack, Porteous, Mark, Porter, David, Porter, Jo, Porter, Linda, Porter, Ross, Posada, Anna, Postlethwaite, Kelly, Potdar, Manoj, Pothecary, Carla, Pothina, Narayana, Potla, Priyadarshan, Potoczna, Dorota, Pott, Jason, Potter, Alison, Potter, Andrew, Potter, Jean, Potter, Sarah, Potter, Tracey, Potton, Elspeth, Potts, Joanne B, Potts, Julie, Potts, Kathryn, Poudyal, Beli, Poultney, Una, Poulton, Katherine, Poustie, Vanessa, Powell, James, Powell, Jordan, Powell, Natassia, Powell, Sandra, Power, Deborah, Power, Nick, Power, Sharon, Poxon, Joseph, Poyner, Emma, Poyner, Robin, Prabhu, Aishwarya, Prabowo, Sandhi, Pradhan, Vidushi, Pradip, Gyanwali, Prady, Helena, Prananingtias, Rosita, Prasad, Aalekh, Prasad, Krishna, Prasad, Usha, Prasanth Raj, Fredy, Prasath, Sangeetha, Pratiwi, Nicky G, Pratley, Anezka, Pratt, Steven, Prayuda, Chrisan Bimo, Preiss, David, Prendergast, Claire, Prentice, Lynn, Prentice, Peter, Prescott, Verity, Presland, Laura, Prest, Catharine, Preston, Stephen, Pretorius, Martha, Prevatt, Natalie, Prew, Sandra, Price, Ashley, Price, Carly, Price, Claire, Price, David, Price, Elizabeth, Price, Katie, Price, Laura J, Price, Nathan, Price, Vivien, Price-Eland, Rachael, Priest, Anne, Prieto, Jimena, Primrose, Lorraine, Prince, Clare, Prince, John, Prince, Judith, Prince, Laura, Pringle, Shirley, Prior-Ong, Melissa, Pristopan, Veronika, Pritchard, Kelly, Pritchard, Lucy, Pritchard, Simon, Priyash, Verma, Procter, Andrew, Proctor, Clare, Protopapas, Mike, Proudfoot, Rebecca, Prudon, Benjamin, Pryor, David, Pudi, Solomon, Puffett, Angela, Pugh, Joanne, Pugh, Lawrence, Pugh, Mark T, Pugh, Nichola, 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Raceala, Madalina, Rachid, Alan, Rachman, Brian Eka, Rachman, Raissa, Rad, Laura, Radford, Jane, Radford, Liz, Radhakrishnan, Jayachandran, Rafferty, Hannah, Rafiq, Muhammad Y, Rafiq, Shabana, Rafique, Cecillia, Rafique, Jethin, Rafique, Muhammad, Ragatha, Ravi, Raghunathan, Aiswarya, Raguro, Abigail, Raha, Shankho D, Rahama, Sana, Rahardjani, Mutia, Rahilly, Karen, Rahim, Faisal, Rahimi, Abdul H, Rahimi, Haseena R, Rahman, Muhammad, Rahman, Salim Ur, Rahmany, Sohail, Rai, Prajan, Rai, Sabi, Rai, Supriya, Raisova, Lenka, Raithatha, Ajay, Raj, Arjun, Rajagopal, Anithya, Rajagopalan, Pradeep, Rajaiah, Nithy, Rajalingam, Kanendran, Rajasekaran, Arvind, Rajasri, Aylur, Rajbhandari, Bibek, Rajbhandari, Sagar, Rajeswaran, Thurkka, Rajeswary, Jyothi, Rajkanna, Jeyanthy, Rajkumar, Indhuja, Rajmohan, Gayathri, Rallan, Ruth, Ralston, Katherine, Ralston, Maximilian, Ram, Matsa, Ramabhadran, Balaji, Ramali, Fathima, Ramali, Mohamed, Ramanan, Athimalaipet, Ramanna, Shashikira, Ramasamy, Maheshi, Rambe, Irfah, Ramchandani, Aradhana, Ramdin, Dhanishta, Ramirez, Jozel, Ramirez, Mylah, Ramnarain, Geshwin, Ramnarine, Amrita, Ramos, Lidia, Rampling, Tommy, Ramraj, Shanthi, Ramsay, Janine, Ramshaw, Alex, Rana, Aleem, Rana, Ghulam F, Rana, Naeem, Rana, Rehman, Rand, Abby, Rand, James, Randheva, Harpal, Ranga, Poonam, Rangar, Manmeet, Rangarajan, Harini, Ranjan, Sameer, Rank, Hannah, Ranka, Poormina, Rankhelawon, Rajesh, Rankin, Alastair, Rao, Anita, Rao, Sandhya, Rao, Sanjay, Rao, Deepak, Rasheed, Althaf A, Rashid, Khalid, Rason, Madeleine, Raspa, Valentina, Rastogi, Somil, Rasul, Fazila, Ratcliff, Simbisai, Ratcliffe, Sam, Ratcliffe, Sophy, Rath, Priti, Rath, Sanjeev, Rather, Mohmad I, Rathod, Krishnaraj, Rathore, Selina, Ratnakumar, Aravinden, Ratoff, Jonathan, Rattehalli, Deepa, Ravaccia, Davide, Raval, Malvi, Ravencroft, Phil, Raw, Jason, Raw, Rachael, Rawal, Manisha, Rawashdeh, Sulaiman A, Rawlins, Hywel, Ray, Gautam, Raymond-White, Adam, Raynard, Dana, Rayner, Helen, Rayner, Nicola, Raynsford, Amy, Razvi, Salman, Razvi, Zarine, Read, Kerry, Read, Sarah, Reay, Michael, Reddington, Anne, Reddy, Ajay, Reddy, Anvesh, Reddy, Harsha, Redfearn, Heidi, Redfern-Walsh, Aine, Redknap, Ianto, Redman, Nell, Redome, Alex, Redome, Joan, Reed, Anna, Reed, John, Rees, Andrew, Rees, Caitlin, Rees, Helen, Rees, James, Rees, Martyn, Rees, Sarah, Rees, Stephanie, Rees, Tabitha, Rees-Jones, Elinor, Regan, Fiona, Regan, Karen, Regan, Martin, Regan, Susan, Rege, Kanchan, Regmi, Amuda, Rehan, Ahmed, Rehman, A, Rehman, Hafiz, Rehman, Shoib, Rehman, Zainab, Reid, Ada, Reid, Andrew, Reid, Jennifer, Reid, Jeremy, Reid, Sharon, Reilly, Mkyla, Reilly, Sharon, Reith, Christina, Reka, Arisa, Remegoso, Alda, Rengan, Dinakaran, Renouf, Louise, Renshaw, Stephen, Renu Vattekkat, Remya, Reschreiter, Henrik, Revels, Mark, Revill, Adam, Rewitzky, Glynis, Rey, Severine, Reynard, Charles, Reynish, Dominic, Reynolds, Heather, Reynolds, Peter, Reynolds, Piero, Rhodes, Jonathan, Riaz, Naghma, Ribeiro, Patricia, Rice, Emily, Rice, Matthew, Rice, Natalie, Rich, Mel, Richards, Alex, Richards, Alison, Richards, Liz, Richards, Suzanne, Richardson, Celia, Richardson, Emma, Richardson, Fiona, Richardson, Jamie, Richardson, Julie, Richardson, Madeleine, Richardson, Neil, Richardson, Nicky, Riches, Joanne, Riches, Katie, Richmond, Leah, Richmond, Ruth, Ricketts, William, Rickman, Hannah, Riddell, Anna, Ridgway, Stephanie, Ridha, Mohamed, Ridley, Carrie, Ridley, Paul, Rieck, Gudrun, Rigby, Linsey, Rigby, Myckala, Rigler, Daniel, Rijal, Samita, Rika, Nur, Riley, Hannah, Riley, Matthew, Riley, Phil, Rimainar, Atika, Rimba, Zwesty V P, Rimmer, Dominic, Rina, Winarni, Rintoul, Robert, Riordan, Andrew, Ripley, David, Rippon, Naomi, Rishton, Chloe, Riste, Michael, Ritchie, David, Ritchie, Jane, Ritchings, Andy, Rivera Ortega, Pilar, Rivers, Vanessa, Rizvi, Batool, Rizvi, Syed A S, Rizvi, Syed H M, Robb, James, Robbins, Edel, Roberts, Charles, Roberts, Gareth, Roberts, Ian, Roberts, Jane, Roberts, Jean, Roberts, Karen, Roberts, Mark, Roberts, Nicky, Roberts, Philip, Roberts, Rebecca, Roberts, Victoria, Robertson, Calum, Robertson, James, Robertson, Jamie, Robertson, Kirsten, Robertson, Nichola, Robertson, Stuart, Robertson, Mhairi, Robin, Nicole, Robinson, Caroline, Robinson, Emma, Robinson, Gisela, Robinson, Hannah, Robinson, Jane, Robinson, Jemima, Robinson, Kate, Robinson, Liz, Robinson, Matthew, Robinson, Nicky, Robinson, Richard, Robinson, Ryan, Robinson, Sandra, Robinson, Alexandra, Robson, Steve, Rocca, Anna, Roche, Lisa, Roche, Samantha, Rodden, Natalie, Roddick, Alistair, Roddy, Elin, Roddy, Jack, Roderick, Marion, Rodger, Alison, Rodger, Faye, Rodger, Megan, Rodger, Michael, Rodger, Megan, Rodgers, Alicia, Rodgers, Deirdre, Rodgers, Natasha, Rodgers, Penny, Rodriguez-Belmonte, Rocio, Roe, Nicholas, Roehr, Charles, Rogers, Gill, Rogers, Jason, Rogers, Joanne, Rogers, John, Rogers, Leigh, Rogers, Lindsay, Rogers, Michaela, Rogers, Paula, Rogers, Susan, Rogers, Thomas, Rojkova, Jana, Roka, Kshetra Kumari, Rokadiya, Sakib, Rollins, Lee, Rollo, Jennifer, Rolls, Catherine, Rond-Alliston, Alexander, Rook, Claire, Rooney, Kevin, Rooney, Lynsey, Rosaroso, Lace P, Rosby, Emily J, Rose, Abigail, Rose, Alastair, Rose, Annie, Rose, Steve, Rose, Zoe, Rosier, Josephine, Roskilly, Anna, Ross, Gavin A, Ross, Isobel, Ross, Jack, Rossdale, Jennifer, Ross-Parker, Andrew, Rostron, Anthony, Rosyid, Alfian Nur, Rothman, Alex, Rothwell, Joanne, Roughley, Lindsay, Rourke, Catherine A, Rowan, Kathryn, Rowan, Neil, Rowan, Stephen, Rowe, Anna, Rowe, Nicola, Rowe-Leete, Louise, Rowlands, Benjamin, Rowlands, Elen, Rowley, Megan, Roy, Subarna, Roycroft, Matthew, Roynon-Reed, Anna, Royson, Ann R, Rozewicz, Sam, Rudenko, Anna, Rudrakumar, Senthan, Rudran, Banu, Ruff, Shannon, Rughani, Prita, Rule, Rory, Rundell, Sharon, Rushforth, Eve, Rushmer, Jeremy, Rusk, Darren, Russell, Peter, Russell, Richard, Russo, Cristina, Rutgers, Marieke, Rutkowski, Krzysztof, Ryan, Aidan, Ryan, Brendan, Ryan, Kathryn, Ryan, Lucy, Ryan, Matthew, Ryan, Pat, Ryan, Phil, Ryan-Wakeling, Declan, Rybka, Elena, Ryder, Maggie, Ryder, Sophie, Saad, M, Saalmink, Gwendolyn, Sabale, Javeson, Sabaretnam, Suganya, Sadiq, Noman, Sadler, Emma, Saffy, Ashiq, Sage, Beth, Sagoo, Harkiran, Sagrir, Sobia, Saha, Rajnish, Saha, Sian, Sahdev, Nikhil, Sahedra, Sarvjit, Sahota, Jagdeep, Said, Nooria, Saini, Shalini, Saint, Bryony, Sajid, Anam, Sakthi, Sreekanth, Sakuri, Hikari, Saladi, Murthy, Salam, Abdul, Salberg, Armorel, Salciute, Erika, Saleeb, Gina, Saleh, Mumtaz, Salih, Hizni, Salih, Laylan, Salim, Duha, Salisbury, Sarah, Saliu, SiteEneye, Salman, Rustam, Salmon, Jenny, Salmon, Rebecca, Salutous, Dario, Sam, Mfon, Sam, Sally, Samakomva, Tinashe, Saman, Razan, Samar, Sakeena, Saminathan, Selva, Samlal, Renaldo, Sammons, Emily, Sammut, David, Sammut, Mark, Sammut, Saud, Sammut, Thomas, Sampath, Sunitha, Sampson, Claire, Sampson, Julia, Samson, Aashna, Samson, Anda, Samuel, Johnson, Samuel, Merna, Samuel, Reena, Samuel, Thomas D L, Samuel, Younan, Samuels, Kevin, Samuels, Theo, Samways, Joanna, Samyraju, Manjula, Sana, Ilves, Sanchez, Veronica, Sanchez Gonzalez, Amada, Sanda-Gomez, Alina, Sandercock, Peter, Sanders, Jack, Sanderson, Amy, Sanderson, Tom, Sandhu, Kuljinder, Sandhu, Loveleen, Sandow, Sam, Sandrey, Victoria, Sands, Sarah, Sanga, Langizya, Sangha, Harwinder, Sanghera, Jasmine, Sangombe, Mirriam, Sanju, Mathew, Sankaran, Lakshmi, Santos, Filipa, Santos Ferreira De Almeida, Catarina, Santosh, Rojy, Sanyal, Jayanta, Sanz-Cepero, Aureo F, Sapkota, Yunima, Saragih, Dan, Saralaya, Dinesh, Saraswati, Anggita, Saraswatula, Arun, Saravanamuthu, Pira, Sarella, Joshua, Sarfatti, Avishay, Sargent, Rebecca, Sari, Beatrix, Sari, Diah, Sarkar, Khatija, Sarkar, Rahuldeb, Sarma, Sruthi, Sarmiento, Paulo, Sarwar, Zainab, Sass, Thea, Satchithananthasivam, Krishna, Sathe, Sonia, Sathianandan, Sobitha, Sathyanarayanan, Abilash, Sathyanarayanan, Lavanya S J P, Sathyapalan, Thozhukat, Satodia, Prakash, Saulite, Vera, Saunders, Andrew, Saunders, Rachel, Saunders, Samantha, Saunderson, Anne, Savill, Heather, Savlani, Karishma, Saxena, Gauri, Saxton, Matthew, Sayan, Amrinder, Sayers, Ian, Scaletta, Diane, Scanlon, Deborah, Scanlon, Jeremy, Scarratt, Lyndsay, Scattergood, Sean, Schadenberg, Alvin, Schafers, Jenna, Schneblen, Wendy, Schofield, Ella, Schofield, Rebecca, Schofield, Samuel, Scholes, David, Scholes, Karen, Schoolmeesters, Alex, Schumacher, Natasha, Schunke, Nicola, Schuster Bruce, Martin, Schwarz, Karin, Scobie, Antonia, Scoones, Thomas, Scorrer, Tim, Scott, Alex, Scott, Alistair, Scott, Anne, Scott, Catherine, Scott, Christine, Scott, Emily, Scott, Kathyn, Scott, Leanne, Scott, Martha, Scott, Stephen, Scott, Timothy, Scott, Zoe, Scourfield, Sarah, Scrase, Wendy, Scriven, Nicholas A, Scullion, Angela, Scullion, Therese, Seager, Emily, Seagrave, Cathy, Seaman, Rebecca, Sear, Eleanor, Seaton, Isabella, Seatter, Annette, Seckington, Anna, Sedano, Joanna, Seddon, Gabrielle, Sedgwick, Gemma, See, Yee Yong, Seelarbokus, Muhammad A, Sefton, Christopher, Segovia, Matias, Seidu, Fatima, Sekadde, Gillian, Selby, Faye, Selby, Georgina, Sellar, Claire, Sellars, Rachael, Sellers, Katharine, Selley, Joseph, Sellick, Victoria, Selvadurai, Gobika, Selvarajah, Brintha, Selvaskandan, Haresh, Selvendran, Subothini S, Selwyn, Jeyakumar, Semmens, Alison, Semple, Gary, Sen, Michael, Sen, Nandini, Sen, Seema, Sengupta, Aditya, Sengupta, Niladri, Senra, Susana, Senya, HoJan, Serafimova, Teona, Sernicola, Elisa, Sethi, Dheeraj, Sethi, Shivam, Setty, Niranjan, Seward, Abigail, Sewdin, Teswaree, Sewell, Terri-Ann, Seymour, Jack, Seymour, Katherine, Shabbir, Hussam, Shackley, Fiona, Shafi, Tariq, Shafique, Faiza, Shah, Aashni, Shah, Ahmar, Shah, Anand, Shah, Bhavni, Shah, Hussun-Ara, Shah, Momin, Shah, Neil, Shah, Pallav, Shah, Priyank, Shah, Qasim, Shah, Rupal, Shah, Sarfaraz H, Shah, Snehal, Shah, Suraj, Shah, Syed, Shah, Wajid, Shahad, Saarma, Shahi, Sousan, Shahnazari, Sipan, Shahzad, Najam, Shahzeb, Muhammad, Shaibu, Aisha, Shaida, Zara, Shaikh, Amina Y, Shaikh, Maliha, Shail, Rajit, Shaji, Mariya, Shakeel, Muhammad, Shakya, Roshni, Shalan, Korah, Shamim, Nadia, Shamji, Ummulbaneen, Shams, Anindya, Shams, Kazi, Shamsah, Rasha, Shanahan, Thomas, Sharaf, Hamed, Sharif, Asir, Sharma, Ajay, Sharma, Ash, Sharma, Bhawna, Sharma, Mona, Sharma, Ojasvi, Sharma, Poonam, Sharma, Rajeev, Sharma, Sagar, Sharma, Sanjeev, Sharma, Sarkhara, Sharma, Seema D, Sharma, Shriv, Sharma, Sonal, Sharp, Alexander, Sharp, Charles, Sharp, Gemma, Sharp, Kerry, Sharp, Louise M, Sharratt, Paula, Sharratt, Phoebe, Sharrocks, Katherine, Shashaa, Serene, Shaw, Alexandra, Shaw, Christopher, Shaw, Daisy, Shaw, David, Shaw, Deborah, Shaw, Joanne, Shaw, Jonathon, Shaw, Lisa, Shaw, Michele, Shaw, Tomos G, Shawcross, Anna, Shawcross, James, Shawe, Jill, Shayler, Lou, Shedwell, Sophy, Sheffield, Jonathan, Shehata, Zak, Sheik, Arshiya, Sheikh, Asif, Sheikh, 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Claudia, Sim, Malcolm, Simangan, Theresa, Simbi, Vimbai, Sime, Robert, Simmons, George, Simmons, Oliver, Simms, Richard, Simon, Laura, Simon, Merritt, Simon, Natalie, Simpkins, Samantha, Simpson, Angela, Simpson, Anna, Simpson, Danny, Simpson, Georgina, Simpson, Joanne, Simpson, Kerry, Simpson, Maria, Simpson, Phillip, Simpson, Thomas, Simpson, Kathryn, Sinclair, Simon, Sing, Cindy, Singh, Ankita, Singh, Claire, Singh, Davinder, Singh, Jayaprakash, Singh, Jyoti, Singh, Lokeshwar, Singh, Manjeet, Singh, Nadira, Singh, Pankaj, Singh, Prabhsimran, Singh, Salil, Singh, Saurabh, Singh, Shivani, Singh, Sumi, Singhal, Parag, Singizi, Bryan, Singler, Vicky, Sinha, Manas, Sinha, Punam, Sinha, Sharad, Sinha, Utkarsh, Sisson, Guy, Sithiravel, Sarah, Sivakumar, Karthikadevi, Sivakumar, Shanmugasundaram, Sivakumran, Darsh, Sivanadarajah, Sivanthi, Sivasothy, Pasupathy-Rajah, Skaria, Asok, Skehan, Nicole, Skelly, Robert, Skelton, Orlagh, Skene, Imogen, Skinner, Denise, Skinner, Tabitha, Skinner, 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Stephensen, David, Stephenson, Elaine, Sterrenburg, Monique, Stevens, Jennifer, Stevens, Melanie, Stevens, Will, Stevenson, Amy, Stevenson, Andrew, Stevenson, Lesley, Stevenson, Sarah, Steward, Matthew, Stewart, Christopher, Stewart, Claire, Stewart, Colin, Stewart, Dobree A, Stewart, Katelyn, Stewart, Keely, Stewart, Kristina, Stewart, McKenna, Stewart, Melissa, Stewart, Rachel, Stewart, Richard, Stickley, Jo, Stiller, Gemma, Stirrup, Sarah, Stock, Sarah, Stockdale, Alexander, Stocker, Danielle, Stockham, Lynne, Stockton, Paul, Stoddard, Emma, Stoffberg, Kevin, Stokes, Chelsea, Stokes, Chris, Stone, Ben, Stone, Roisin, Stone, Sarah, Stoner, Emma-Jane, Storey, Imogen, Storton, Kim, Stourton, Frederick, Strachan, Angela, Strait, Catherine, Stratton, Emma, Stratton, Jane, Straw, Sam, Streit, Dieter, Stride, Emma, Stringer, Sally, Strong-Sheldrake, Sophia, Struik, Siske, Stuart, Carmel, Stubbs, Anna, Stubbs, Harrison, Sturdy, Ann, Sturney, Sharon, Stuttard, Matt, Suarez, Cristina, Subba, Karuna, Subbe, Christian P, Subramaniam, Keerth, Subramanian, Manjula, Subramanian, Vaidyanathan, Subramanian, Venkatram, Subudhi, Chinari, Suckling, Rebecca, Sudershan, Srivatsan, Sugden, Peter, Suherman, Putri A, Sukla, Rudresh, Sukumaran, Anila, Suleiman, Ezoubi, Suliman, Ali, Suliman, Fatimah, Sultan, Sugrah, Sumardi, Uun, Sundar, Samyukta, Sundaram, Radha, Sundhar, Reka, Sung, Edmond, Sunni, Nadia, Suntharalingam, Jay, Sur, Amitava, Suresh, Dharmic, Suresh, Nayanika, Suresh, Shilpa, Surtees, Michael, Susan, C, Suter, Danielle, Suthar, Rohan, Sutherland, Helen, Sutherland, Rachel, Sutherland, Rebecca, Sutherland, Sara-Beth, Sutinyte, Dovile, Sutton, Deborah, Sutton, Sam, Sutton, Siobhan, Sutu, Mihaela, Svensson, Marie-Louise, Svirpliene, Sima, Swain, Andrew, Swain, Rose, Swaine, Thomas, Swales, Christopher, Swanson-Low, Carla, Swart, Tirion, Sweetman, Stephen, Swift, Ealish, Swift, Paul, Swift, Pauline, Swift, Rachael, Swingler, Rachel, Swinhoe, Sophie, Swist-Szulik, Katarzyna, 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Alexander, Taylor, Beverley, Taylor, Charlie, Taylor, Charlotte A, Taylor, David, Taylor, Elisabeth, Taylor, Holly, Taylor, Janet, Taylor, Jennifer, Taylor, Joanne, Taylor, Julie, Taylor, Karen, Taylor, Leanne, Taylor, Margaret, Taylor, Matthew, Taylor, Melanie, Taylor, Natalie, Taylor, Rachael, Taylor, Rachel, Taylor, Samantha, Taylor, Suzanne, Taylor, Tracey, Taylor, Vicky, Taylor, Victoria, Taylor-Siddons, Michelle, Taynton, Thomas, Te, Amelia, Teasdale, Francesca, Teasdale, Jessica, Teasdale, Katherine, Tebbutt, Julie, Tee, Caroline, Teeluck, Izla, Tejero Moya, Borja, Tejwani, Rajni, Telfer, Adam, Teli, Vibha, Tempany, Jennifer, Temple, Julie, Temple, Natalie, Tench, Helen, Teoh, Yi He, Tereszkowski-Kaminski, Radoslaw, Terrett, Lynne, Terry, Louise, Tesha, Tesha Islami Monika, Tetla, Dariusz, Tewari, Shirish, Tewkesbury, Daniel, Texeira, Joana, Tey, ChiaLing, Thake, Miriam, Thakker, Clare, Thakker, Manish, Thakrar, Jayna, Thakuri, Bishal Jung, Thamu, Bhavneet, Thao, Nguyen Thi, Thapa, Amita, Thatcher, Hilary, Thayanandan, Andrew, Thazhatheyil, Krishna, Thein, Eaint, Theocharidou, Lambrini, Thet, Phyu, Thevarajah, Kapeendran, Thevendra, Mayooran, Thiri Phoo, Nang, Thirlwall, Yvette, Thirumaran, Muthu, Thomas, Alice, Thomas, Andrew, Thomas, Caradog, Thomas, Emma, Thomas, Enson, Thomas, Esther, Thomas, Helen, Thomas, James, Thomas, Jordan L, Thomas, Karen, Thomas, Koshy, Thomas, Lucy, Thomas, Rachel, Thomas, Rebecca, Thomas, Rhys, Thomas, Ruth, Thomas, Sarah, Thomas, Sherine, Thomas, Tessy, Thomas, Vicky, Thomasson, Kirsty, Thomas-Turner, Rhian, Thompson, Catherine, Thompson, Christopher, Thompson, Clara, Thompson, Emma, Thompson, Fiona, Thompson, Hilary, Thompson, Jessica, Thompson, Katharine, Thompson, Laura, Thompson, Liz, Thompson, Luke, Thompson, Michael, Thompson, Orla, Thompson, Rebecca, Thompson, Roger, Thompson, Yolanda, Thomson, Nicola, Thorburn, Patrick, Thorn, Natasha, Thorne, Charlotte, Thorne, Nicola, Thornton, Alice, Thornton, Danielle, Thornton, Jim, Thornton, Richard, Thornton, Sara, Thornton, Susan, Thornton, Thomas, Thornton, Tracey, Thorpe, Christopher, Thorpe, Nigel, Thorpe, Sarah, Thozthumparambil, Paradeep, Thrasyvoulou, Laura, Thraves, Hannah, Thueux, Genevieve, Thuong, Nguyen Thi Huyen, Thu-Ta, Pinky, Thwaiotes, Vicky, Thwaites, C Louise, Thwaites, Guy, Tiberi, Simon, Tieger, Serena, Tierney, Carey, Tierney, Caroline, Tighe, Mark, Tilbey, Sorrell, Till, Christopher, Tiller, Amanda, Tiller, Heather, Timerick, John, Timlick, Elizabeth, Timmins, Alan, Timmis, Alison, Timms, Hayley, Timoroksa, Anne-Marie, Tinashe, Samakomva, Tingley, Stephanie, Tinker, Nicola, Tinkler, Heather, Tinkler, Marianne, Tipper, Jacqui, Tirumalai Adisesh, Ajay, Tivenan, Helen, Tluchowska, Katarzyna, T-Michael, Helen, Todd, Anne, Todd, Jackie, Todd, Shirley, Todd, Stacy, Toffoletti, Olga, Tohfa, Mohamed, Tohill, Sue, Tolson, Melanie, Tomas, Ana L, Tomasova, Natalia, Tomlin, Sharon, Tomlins, Simon, Tomlinson, Jo, Tomlinson, Kerry, Tonkin, James, Tonna, Ivan, Toohey, Catherine, Topham, Kirsty, Topping, Mathew, Torokwa, Audrey, Torrance, Collette, Touma, Omar, Tous Sampol, Laura, Tousis, Ruhaif, Tout, Melissa, Tovey, Peter, Towersey, Gareth, Townley, Jill, Tozer, Richard, Tran, Dang Khoa, Tran, Hien, Tran, Huyen Bang, Tran, Michelle, Tran, Nguyen Bao, Tran, Van Giang, Tran, Van Kien, Tranter, Helen, Travers, Jenny, Travill, Christopher, Traynor, Sarah, Trethowan, Leanne, Treus Gude, Estefania, Trevelyan, Mary, Trewick, Nicola A, Tridente, Ascanio, Triggs, Sanchia, Trim, Fiona, Trimmings, Alex, Trinick, Tom, Trivedi, Kate, Troedson, Sven, Tropman, Emily, Trotter, Amy, Trous, Spyridon, Trower, Helen, Trowsdale Stannard, Madeleine, Trudgill, Nigel, Truell, Robert, Truman, Nick, Truslove, Maria, Trussell, Shaun, Trussell, Tariq, Tsakiridou, Kyriaki, Tsang, Christine, Tsang, Peter, Tsawayo, Tan, Tsilimpari, Kyriaki K, Tsinaslanidis, Georgios, Tsitsi, Merika, Tso, Simon, Tucker, Natasha, Tucker, Sally, Tucker, Stephanie, Tudor, Daisy E, Tufail, Aisha, Tuff, Jess, Tuffney, Jemma, Tully, Redmond, Tulus Satriasih, Tulus, Tunesi, Grace, Turbitt, Killiam, Turel, Rezon, Turgut, Tolga, Turley, Claudia, Turnbull, Alison, Turner, Aine, Turner, Ash, Turner, Charlotte, Turner, Gail, Turner, Georgina, Turner, Kate, Turner, Kelly, Turner, Kim, Turner, Lucy, Turner, Lynne C, Turner, Mark, Turner, Patricia, Turner, Sally, Turner, Samantha, Turner, Sarah, Turner, Victoria, Turner-bone, Ian, Turney, Sharon, Turvey, Jon, Tweed, Conor, Tweed, David, Twemlow, Rebecca, Twohey, Emma, Tyagi, Bhavya, Tyagi, Vedang, Tyer, Abigail, Tyler, Amanda, Tyler, Jayne, Tyler, Jennifer, Tyzack, Alison, Tzavaras, Petros, Tzinieris, Ioannis, Uddin, A Wahid, Uddin, Mohammad S, Uddin, Ruhama, Uddin, Ruzena, Ugoji, Jacinta, Ukaegbu, Edith N, Ul Haq, Mazhar, Ul Hassan, Waqar, Ul-Haq, Zia, Ullah, Salamat, Ullah, Sana, Ullah, Sanda, Um, Ju, Umaipalan, Athavan, Umate, Anil, Umeadi, Judith, Umeh, Akudo, Umeojiako, Wilfred, Ummat, Ben, Underhill, Emma, Underwood, Charlotte, Underwood, Jonathan, Unsworth, Adam, Uppal, Veerpal, Uppal, Veerpal S, Upson, Gerry, Ur Rasool, Masood, Uriel, Alison, Urruela, Sebastian, Uru, Hiromi, Usher, Jess, Usher, Miranda, Usher, Rebecca, Usher-Rea, Alexandra, Ustianowski, Andrew, Usuf, Effua, Utomo, Febriansyah Nur, Uzu, Hiromi, Vaccari, Linda C, Vaghela, Uddhav, Vaidya, Abhay, Vail, Denny, Valecka, Bernardas, Valentine, Jennifer, Valeria, Balan, Vallabhaneni, Pramodh, Vallotton, Nick, Vamplew, Luke, Vamvakiti, Ekaterini, Vamvakopoulos, Joannis, Van Blydenstein, Sarah, van Bruggen, Lucia, van de Venne, Maud, van der Meer, Alex, van der Stelt, Nora, Van Doorn, Rogier, van Koutrik, Lynne, Van Loggerenberg, Alexander, Vance-Daniel, Joseph, Vancheeswaran, Rama, Vandeyoon, Samuel I, Vankayalapati, Padma, Vanmali, Piyush, Vansomeren, Chloe, Van't Hoff, William, Vara, Sejal, Vardy, Stehen J, Varghese, Anu, Varghese, Maria, Varney, William, Varnier, Giulia, Varouxaki, Anna-Nektaria, Varquez, Resti, Vasadi, Valeria, Vass, Olivia, Vassell, Katherine, Vasu, Vimal, Vasudevan, Vasanthi, Vatish, Manu, Vaughan, Sue, Vayalaman, Heloyes, Vayapooree, Darini, Vaz, Christopher, Veale, Niki, Veerasamy, Sachuda, Velankar, Swati, Velauthar, Luxmi, Veli, Neyme, Vella, Nicola, Velugupati, Aravind, Velusamy, Anitha, Venables, Ian, Venditti, Mavi, Venkataramakrishnan, Ramya, Venn, Richard, Venn, Robert, Venter, Michelle, Ventilacion, Lyn, Vere, Joanne, Veres, Mark, Vergnano, Stefania, Verling, Will, Verma, Amit, Vernall, Rachel, Vernon, Britney, Vertue, Mark, Verueco, Liberty, Verula, Jerik, Veterini, Anna, Vethanayagam, Natalie, Vettikumaran, Shambavi, Veys, Lucy, Vickers, Carinna, Victor, Saji, Victoria, SImpson, Vidaillac, Celine P, Vidler, Jennifer, Vijayakumar, Bavithra, Vijayaraghavan Nalini, Vinod W, Vilcinskaite, Brigita, Vileito, Alicija, Vilimiene, Neringa, Vinall, Lynn, Vinay, Sylvia, Vinayakarao, Latha, Vincent, Olivia, Vincent, Rachel, Vincent, Rosie, Virdee, Pritpal, Virgilio, Emma, Virk, Abdullah M, Visentin, Elisa, Vitaglione, Martina, Vithian, Karunakaran, Vittoria, Sorice, Vivekananthan, Sankkita, Vlad, Elena, Vlies, Ben, von Oven, Linda, Vooght, Claire, Vu Thai, Kim Thi, Vutipongsatorn, Kritchai, Vuylsteke, Alain, Vyras, Eleftheria, Wach, Richard, Wadams, Beverley, Wadd, Susan, Waddington, Natalia, Wade, Phillip, Wadsley, Jonathan, Wadsworth, Kirsten, Wafa, Syed E I, Wagstaff, Daniel, Wagstaff, Lynda, Wahab, Dalia, Wahbi, Zaroug, Waheed Adigun, Abiodun, Waidyanatha, Sawan, Waite, Alicia, Wake, Rachel, Wakefield, Alice, Wakeford, William, Wakinshaw, Fiona, Waldeck, Emma, Walden, Andrew, Walding, Lorna, Waldron, Alexandria, Waldron, Joanne, Wales, Emma, Wali, Batool, Walker, Danielle, Walker, Gemma, Walker, Harriet, Walker, Ian, Walker, Kevin, Walker, Kim, Walker, Lauren, Walker, Linda, Walker, Lynne, Walker, Olivia, Walker, Rachel, Walker, Rebecca, Walker, Sara, Walker, Susan, Wallace, Gillian, Wallbutton, Rebecca, Wallen, Jessica, Wallendszus, Karl, Waller, Arabella, Waller, Rosemary, Wallis, Gabiel, Wallis, Gabriel, Wallis, Louise, Wallis, Matthew, Walmsley, Emma, Walsh, Donna, Walsh, Elizabeth, Walsh, Livia, Walstow, Deborah, Walter, Daniel, Walters, Alex, Walters, Holt, Walters, James, Walters, Jocelyn, Walton, Eileen, Walton, Lucy, Walton, Maisie, Walton, Michael, Walton, Olivia, Walton, Sharon, Walton, Susan, Wan, Mandy, Wanda, Junita, Wands, Mary, Wane, Rachel, Wang, Frank, Wang, Nick, Wang, Ran, Wang, Shentong, Warbrick, Deborah, Warburton, Samantha, Ward, Christopher, Ward, Deborah, Ward, Emma, Ward, Hannah, Ward, Janice, Ward, Joanna, Ward, Luke, Ward, Nicola, Ward, Rachael, Ward, Thomas, Ward, Tom, Warden, Scott A, Wardere, Gibril, Wardle, Steve, Wardy, Hassan, Waring, Gareth, Waring, Scott, Warmington, Jenny, Warner, Ben, Warner, Christian, Warnock, Lewis, Warran, Sarah, Warren, Jade, Warren, Lisa, Warren, Rebecca, Warren, Yolanda, Warrender, Davina, Warren-Miell, Hannah, Warris, Adilia, Warwick, Gill, Wassall, Helen, Wasserman, Sean, Wasson, Elizabeth, Watchorn, Hazel J, Waterfall, Holly, Waters, Abby, Waters, Donald, Waterstone, Mark, Watkin, Abigail, Watkins, Catherine, Watkins, Catrin, Watkins, Eleanor, Watkins, Karen, Watkins, Lynn, Watson, Abigail, Watson, Adam J R, Watson, Ekaterina, Watson, Eleanor, Watson, Felicity, Watson, J G R, Watson, Louisa, Watson, Paul, Watson, Rebecca, Watson, Robert, Watson, Kathleen, Watters, Malcolm, Watterson, Donna, Wattimena, Khairiah, Watts, Daniel, Watts, John, Watts, Merlin, Waugh, Victoria, Wayman, Emma, Wayman, Matthew, Wazir, Akhlaq, Weatherhead, Mark, Weatherly, Nick, Webb, Chloe, Webb, Claire, Webb, Hayley, Webb, Kathryn, Webb, Kylie, Webb, Stephen, Websdale, Cheryl, Webster, Deborah, Webster, Ian, Webster, Jemma, Webster, Tim, Wedlin, Jordan, Wee, Ling, Weerakoon, Rebecca, Weerasinghe, Thanuja, Weeratunga, Janaka, Weetman, Maria, Wei, Shuying, Weichert, Immo, Welch, Emma, Welch, Hugh, Welch, James, Welch, Leanne, Welch, Steven, Welham, Benjamin, Weller, Samantha, Wellings, Lucy, Wells, Brian, Wellstead, Susan, Welsh, Berni, Welsh, Richard, Welters, Ingeborg, Welton, Rachael, Wenn, Victoria, Wentworth, Lauren, Wesonga, Joan, Wesseldine, Kate, West, Joe, West, Magdelena, West, Raha, West, Ruth, West, Sophie, Western, Luke, Westhead, Ruth, Weston, Heather, Westwood, Alice, Westwood, Kelly, Westwood, Sharon, Wetherill, Bill, Wheaver, Sharon, Wheeler, Helen, Whelan, Ben, Whelband, Matthew, Whileman, Amanda, Whitcher, Alison, White, Andrew, White, Ayesha, White, Benjamin, White, Catherine, White, Christopher, White, Duncan, White, James, White, Jonathan, White, Katie, White, Marie, White, Nick, White, Nikki, White, Sarah, White, Sonia, White, Tracey, Whitehead, Catherine, Whitehorn, Kelly, Whitehouse, Anne, Whitehouse, Claire, Whitehouse, Tony, Whiteley, Julia, Whiteley, Louiza, Whiteley, Sophie, Whitham, Rachael, Whitlingum, Gabriel, Whitmore, David, Whittaker, Elizabeth, Whittam, Lindsay, Whittington, Ashley, Whittle, Helen, Whittle, Robert, Wiafe, Eunice, Wiblin, Lou, Wickens, Olivia, Widdrington, John, Wieboldt, Jason, Wieringa, Hannah, Wiesender, Cornelia, Wiffen, Laura, Wight, Andrew, Wignall, Ashleigh, Wignall, Christopher, Wilce, Annamaria, Wilcock, Danielle, Wilcock, Emma, Wilcox, Louise, Wild, Ben, Wild, Laura, Wild, Stephen, Wilde, Michael, Wilding, Laura, Wilding, Peter, Wildsmith, Tracey, Wileman, Joe, Wiles, Joy, Wiles, Kate, Wilhelmsen, Elva, Wiliams, Thomas, Wilkie, Janet, Wilkin, David, Wilkins, Hannah, Wilkins, Joy, Wilkins, Suzanne, Wilkinson, Iain, Wilkinson, Lesley, Wilkinson, Nicola, Wilkinson, Sophia, Wilkinson, Susan, Wilkinson, Tim, Willetts, Sylvia, Williams, Aimee, Williams, Alexandra, Williams, Alison, Williams, Angharad, Williams, Anna, Williams, Ava, Williams, Carl, Williams, Caroline V, Williams, Claire, Williams, Dewi, Williams, Eleri, Williams, Gail, Williams, Gemma, Williams, Gina, Williams, Hannah, Williams, Heledd, Williams, James, Williams, Jennie, Williams, Jill, Williams, John, Williams, Joseph, Williams, Karen, Williams, Kathryn, Williams, Mandy, Williams, Marie, Williams, Mark, Williams, Matthew, Williams, Patricia, Williams, Penny, Williams, Rachel, Williams, Robin, Williams, Rupert, Williams, Samson, Williams, Sarah, Williams, Sophie, Williams, Steffan, Williams, Tamanna, Williams, Tania, Williams, Sarah, Williamson, Annie, Williamson, Cath, Williamson, Catherine, Williamson, Dawn, Williamson, James D, Williamson, Jodie, Williamson, Rachel, Williamson, Cath, Williamson, Helen, Willis, Elaine, Willis, Elizabeth, Willis, Emily, Willis, Heather, Willis, Herika, Willis, Joanna, Wills, Louise, Willsher, Lucy, Willshire, Catherine, Willson, Francesca, Willson, Jayne, Wilson, Alison, Wilson, Andrea, Wilson, Anna, Wilson, Antoinette, Wilson, Billy, Wilson, David, Wilson, Imogen, Wilson, James, Wilson, Karen, Wilson, Kate, Wilson, Kristy-Ann, Wilson, Lucinda, Wilson, Mark, Wilson, Stephen, Wilson, Toni, Wilson, John, Win, Khin Lei Yee, Win, Marlar, Win, Than, Win, Tin Tin, Win, Wut Yee Win, Winckworth, Lucinda, Winder, Laura, Winder, Piers, Winearl, Stuart, Winmill, Helen, Winn, Simon, Winpenny, Carmen, Winslow, Helen, Winter, Helen, Winter, Jonathan, Winter-Goodwin, Barbara, Winterton, Joseph, Winwood, Hannah, Wischhusen, Jack, Wisdom, Stephen, Wise, Matthew, Wiselka, Martin, Wiseman, Rebecca, Wiseman, Sophie, Wishart, Steven, WIshlade, Tabitha, Witele, Eric, Withers, Nicholas, Wittes, Janet, Wixted, Donna, Wodehouse, Therese, Wolf, Will, Wolff, Nicola, Wolffsohn, Kirsten, Wolf-Roberts, Rebecca, Wolodimeroff, Elena, Wolstencroft, Adam, Wong, Alan, Wong, Charlotte, Wong, Chi-Hung, Wong, Chi-Man, Wong, Edwin, Wong, Jessica S Y, Wong, Kit Y, Wong, Mei Yin, Wong, Nick, Wong, Sam, Wong, Ting, Wongkyezeng, Aaron B, Wood, Amanda, Wood, Caroline, Wood, Dianne, Wood, Fiona, Wood, Gordon, Wood, Hannah, Wood, Jennifer, Wood, Joe, Wood, Lisa, Wood, Louise, Wood, Madeleine, Wood, Stephen, Wood, Stephen, Wood, Tracy, Woodall, Katharine, Woodfield, Rebecca, Woodford, Christopher, Woodford, Elizabeth, Woodford, Jill, Woodhead, Louise, Woodhead, Timothy, Woodland, Philip, Woodman, Marc, Woodman, Myles, Woodmansey, Stephen, Woods, Charlotte, Woods, Jane, Woods, Katherine, Woods, Sarah, Woodward, Zoe, Woolcock, Megan, Wooldridge, Gemma, Woolf, Rebecca, Woollard, Chris, Woollard, Christopher, Woollen, Louisa, Woolley, Emma, Woolley, Jade, Woosey, Daniel, Wootton, Dan, Wootton, Joanne, Worley, Daniel, Worton, Stephy, Wraight, Jonathan, Wray, Maria, Wren, Kim, Wren, Lynn, Wrey Brown, Caroline, Wright, Catherine, Wright, Demi, Wright, Francesca, Wright, Holly, Wright, Imogen, Wright, Lianne, Wright, Rachel, Wright, Sarah, Wright, Stephanie, Wright, Tim, Wroe, Caroline, Wroe, Hannah, Wu, Henry, Wu, Peishan, Wu, Pensee, Wubetu, Jonathan, Wulandari, Fitria, Wulandari, Retno, Wurie, Subie, Wyatt, Craig, Wyn-Griffiths, Frederick, Wynter, Inez, Xavier, Bindhu, Xhikola, Arnold, Xia, Bingru E, Xia, Zhongyang, Yacoba, Effua, Yadav, Santosh, Yakubi, Masseh, Yan, May, Yanagisawa, Yuuki, Yang, Freda, Yang, Yingjia, Yanney, Michael, Yap, Woei Lin, Yaqoob, Nabil, Yasmin, Salima, Yates, Bryan, Yates, David, Yates, Edward, Yates, Helen, Yates, Thomas, Yates, Mark, Ye, Jessica, Yearwood Martin, Charlotte, Yein, Khin, Yelnoorkar, Fiona, Yen, Lam Minh, Yeoh, Alastair, Yeung, Chun Yu, Yew, Peter, Yewatkar, Durgesh, Ylquimiche Melly, Laura, Ynter, Inez, Yong, H, Yorke, Jemma, Youens, Jasmine, Younes Ibrahim, Abdel, Young, Eoin, Young, Gail, Young, Louise, Yousafzar, Asfand, Youssouf, Sajeda, Yousuf, Ahmed, Yovita, Hartantri, Yu, Chrissie, Yuan, Jack S J, Yufaniaputri, Nindya, Yung, Bernard, Yusef, Daniel, Yusef, Said, Yusuf, Intekhab, Zafar, Anna-Sophia, Zagalo, Silvia, Zaher, Su, Zahoor, Aqsa, Zainab, Mahrukh, Zak, Thornton, Zaki, Kareem, Zakir, Nabhan, Zalewska, Kasia, Zamalloa, Ane, Zaman, Mohsin, Zaman, Shakir, Zamikula, Julie, Zammit, Louise, Zammit-Mangion, Marie, Zawadzka, Marcelina, Zayed, Mohammed, Zebracki, Esther, Zehnder, Daniel, Zeidan, Lisa, Zeinali, Darius, Zhang, Jing, Zhao, Xiaobei, Zheng, Dongling, Zhu, Doreen, Zia, Madiha, Zibdeh, Omar, Zill-E-Huma, Rabia, Zin, Ei Thankt, Zincone, Eva, Zindoga, Garikai, Zinkin, Eleanor, Zinyemba, Vivian, Zipitis, Christos, Zitter, Letizia, Zmierczak, Arkadiusz, Zubikarai, Garazi, Zubir, Azam, Zuhra, Naz, Zulaikha, Rasha, Zulfikar, Sabrina, Zullo, Carol, and Zuriaga-Alvaro, Ana
  • The Lancet; May 2023, Vol. 401 Issue: 10387 p1499-1507, 9p
Abstract
Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group.

23. Is there equity of patient health outcomes across models of general practice in Aotearoa New Zealand? A national cross-sectional study [2023]

  • Sheridan, Nicolette, Love, Tom, Kenealy, Timothy, Aguirre-Duarte, Nelson, Arroll, Bruce, Atmore, Carol, Carryer, Jenny, Crampton, Peter, Dowell, Anthony, Fishman, Tana, Gauld, Robin, Harwood, Matire, Hoare, Karen, Jackson, Gary, Jansen, Rawiri McKree, Kerse, Ngaire, Lampshire, Debra, McBain, Lynn, MacRae, Jayden, Mills, Jane, Øvretveit, John, Percival, Teuila, Perera, Roshan, Roland, Martin, Ryan, Debbie, Schmidt-Busby, Jacqueline, Stokes, Tim, Stubbe, Maria, Hewitt, Sarah, Watt, Daniel, and Peck, Chris
  • International Journal for Equity in Health. May 4, 2023, Vol. 22 Issue 1

24. MP-453090-9 FINDINGS FROM TWELVE YEARS OF FAMILY SCREENING AFTER SUDDEN CARDIAC DEATH. [2023]

  • Brown, Stewart, Bailey, Janice, Wang, Robin, Kemp, Jacqueline, Strawbridge, Martyn, Sheppard, Mary, Dayer, Mark J., and Furniss, Guy O.
  • Heart Rhythm; 2023 Supplement, Vol. 20 Issue 5, pS117-S118, 2p

25. Patient-reported outcome measures and patient engagement in heart failure clinical trials: multi-stakeholder perspectives. [2023]

  • Zannad F, Alikhaani J, Alikhaani S, Butler J, Gordon J, Jensen K, Khatib R, Mantovani L, Martinez R, Moore WF, Murakami M, Roessig L, Stockbridge N, Van Spall HGC, Yancy C, and Spertus JA
  • European journal of heart failure [Eur J Heart Fail] 2023 Apr; Vol. 25 (4), pp. 478-487. Date of Electronic Publication: 2023 Mar 22.
Subjects
Humans, Patient Participation, Patient Reported Outcome Measures, Caregivers, Quality of Life, and Heart Failure therapy
Abstract
There are many consequences of heart failure (HF), including symptoms, impaired health-related quality of life (HRQoL), and physical and social limitations (functional status). These have a substantial impact on patients' lives, yet are not routinely captured in clinical trials. Patient-reported outcomes (PROs) can quantify patients' experiences of their disease and its treatment. Steps can be taken to improve the use of PROs in HF trials, in regulatory and payer decisions, and in patient care. Importantly, PRO measures (PROMs) must be developed with involvement of patients, family members, and caregivers from diverse demographic groups and communities. PRO data collection should become more routine not only in clinical trials but also in clinical practice. This may be facilitated by the use of digital tools and interdisciplinary patient advocacy efforts. There is a need for standardization, not only of the PROM instruments, but also in procedures for analysis, interpretation and reporting PRO data. More work needs to be done to determine the degree of change that is important to patients and that is associated with increased risks of clinical events. This 'minimal clinically important difference' requires further research to determine thresholds for different PROMs, to assess consistency across trial populations, and to define standards for improvement that warrant regulatory and reimbursement approvals. PROs are a vital part of patient care and drug development, and more work should be done to ensure that these measures are both reflective of the patient experience and that they are more widely employed.
(© 2023 European Society of Cardiology.)

26. Implementation of a Web-Based Communication System for Primary Care Providers and Cancer Specialists. [2023]

  • Petrovic B, Bender JL, Liddy C, Afkham A, McGee SF, Morgan SC, Segal R, O'Brien MA, Julian JA, Sussman J, Urquhart R, Fitch M, Schneider ND, and Grunfeld E
  • Current oncology (Toronto, Ont.) [Curr Oncol] 2023 Mar 21; Vol. 30 (3), pp. 3537-3548. Date of Electronic Publication: 2023 Mar 21.
Subjects
Humans, Continuity of Patient Care, Surveys and Questionnaires, Communication, Internet, and Neoplasms therapy
Abstract
Healthcare providers have reported challenges with coordinating care for patients with cancer. Digital technology tools have brought new possibilities for improving care coordination. A web- and text-based asynchronous system (eOncoNote) was implemented in Ottawa, Canada for cancer specialists and primary care providers (PCPs). This study aimed to examine PCPs' experiences of implementing eOncoNote and how access to the system influenced communication between PCPs and cancer specialists. As part of a larger study, we collected and analyzed system usage data and administered an end-of-discussion survey to understand the perceived value of using eOncoNote. eOncoNote data were analyzed for 76 shared patients (33 patients receiving treatment and 43 patients in the survivorship phase). Thirty-nine percent of the PCPs responded to the cancer specialist's initial eOncoNote message and nearly all of those sent only one message. Forty-five percent of the PCPs completed the survey. Most PCPs reported no additional benefits of using eOncoNote and emphasized the need for electronic medical record (EMR) integration. Over half of the PCPs indicated that eOncoNote could be a helpful service if they had questions about a patient. Future research should examine opportunities for EMR integration and whether additional interventions could support communication between PCPs and cancer specialists.

27. Percentage of Adults Aged 18-64 Years Who Used Telemedicine in the Past 12 Months, by Sex and Health Insurance Coverage -- National Health Interview Survey, United States 2021. [2023]

  • Lucas, Jacqueline, Villarroel, Maria, and Cohen, Robin
  • MMWR: Morbidity & Mortality Weekly Report. 3/3/2023, Vol. 72 Issue 9, p244-244. 1p. 1 Graph.
Subjects
TELEMEDICINE, MEDICAL personnel, and PUBLIC health
Abstract
The article analysis the statistics related to telemedicine visit with a health care professional.

28. This title is not available for guests. Log in to see the title and access the article.

29. Patterns of failure in pediatric medulloblastoma and implications for hippocampal sparing. [2023]

  • Baliga S, Adams JA, Bajaj BVM, Van Benthuysen L, Daartz J, Gallotto SL, Lewy JR, DeNunzio N, Weyman EA, Lawell MP, Palmer JD, Yeap BY, Ebb DH, Huang MS, Perry AF, MacDonald SM, Jones RM, Tarbell NJ, and Yock TI
  • Cancer [Cancer] 2023 Mar 01; Vol. 129 (5), pp. 764-770. Date of Electronic Publication: 2022 Dec 11.
Subjects
Humans, Child, Organ Sparing Treatments methods, Organs at Risk, Protons, Prospective Studies, Radiotherapy Planning, Computer-Assisted methods, Radiotherapy Dosage, Cranial Irradiation adverse effects, Cranial Irradiation methods, Neoplasm Recurrence, Local epidemiology, Hippocampus diagnostic imaging, Medulloblastoma radiotherapy, Brain Neoplasms radiotherapy, Brain Neoplasms secondary, Radiotherapy, Intensity-Modulated methods, and Cerebellar Neoplasms radiotherapy
Abstract
Background: Hippocampal avoidance (HA) has been shown to preserve cognitive function in adult patients with cancer treated with whole-brain radiation therapy for brain metastases. However, the feasibility of HA in pediatric patients with brain tumors has not been explored because of concerns of increased risk of relapse in the peri-hippocampal region. Our aim was to determine patterns of recurrence and incidence of peri-hippocampal relapse in pediatric patients with medulloblastoma (MB).
Methods and Materials: We identified pediatric patients with MB treated with protons between 2002 and 2016 and who had recurrent disease. To estimate the risk of peri-hippocampal recurrence, three hippocampal zones (HZs) were delineated corresponding to ≤5 mm (HZ-1), 6 to 10 mm (HZ-2), and >10 mm (HZ-3) distance of the recurrence from the contoured hippocampi. To determine the feasibility of HA, three standard-risk patients with MB were planned using either volumetric-modulated arc therapy (VMAT) or intensity-modulated proton therapy (IMPT) plans.
Results: Thirty-eight patients developed a recurrence at a median of 1.6 years. Of the 25 patients who had magnetic resonance imaging of the recurrence, no patients failed within the hippocampus and only two patients failed within HZ-1. The crude incidence of peri-hippocampal failure was 8%. Both HA-VMAT and HA-IMPT plans were associated with significantly reduced mean dose to the hippocampi (p < .05). HA-VMAT and HA-IMPT plans were associated with decreased percentage of the third and lateral ventricles receiving the prescription craniospinal dose of 23.4 Gy.
Conclusions: Peri-hippocampal failures are uncommon in pediatric patients with MB. Hippocampal avoidance should be evaluated in a prospective cohort of pediatric patients with MB.
Plain Language Summary: In this study, the patterns of disease recurrence in patients with a pediatric brain tumor known as medulloblastoma treated with proton radiotherapy were examined. The majority of failures occur outside of an important structure related to memory formation called the hippocampus. Hippocampal sparing radiation plans using proton radiotherapy were generated and showed that dose to the hippocampus was able to be significantly reduced. The study provides the rationale to explore hippocampal sparing in pediatric medulloblastoma in a prospective clinical trial.
(© 2022 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.)

30. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group. [2023]

  • Groenewold NA, Bas-Hoogendam JM, Amod AR, Laansma MA, Van Velzen LS, Aghajani M, Hilbert K, Oh H, Salas R, Jackowski AP, Pan PM, Salum GA, Blair JR, Blair KS, Hirsch J, Pantazatos SP, Schneier FR, Talati A, Roelofs K, Volman I, Blanco-Hinojo L, Cardoner N, Pujol J, Beesdo-Baum K, Ching CRK, Thomopoulos SI, Jansen A, Kircher T, Krug A, Nenadić I, Stein F, Dannlowski U, Grotegerd D, Lemke H, Meinert S, Winter A, Erb M, Kreifelts B, Gong Q, Lui S, Zhu F, Mwangi B, Soares JC, Wu MJ, Bayram A, Canli M, Tükel R, Westenberg PM, Heeren A, Cremers HR, Hofmann D, Straube T, Doruyter AGG, Lochner C, Peterburs J, Van Tol MJ, Gur RE, Kaczkurkin AN, Larsen B, Satterthwaite TD, Filippi CA, Gold AL, Harrewijn A, Zugman A, Bülow R, Grabe HJ, Völzke H, Wittfeld K, Böhnlein J, Dohm K, Kugel H, Schrammen E, Zwanzger P, Leehr EJ, Sindermann L, Ball TM, Fonzo GA, Paulus MP, Simmons A, Stein MB, Klumpp H, Phan KL, Furmark T, Månsson KNT, Manzouri A, Avery SN, Blackford JU, Clauss JA, Feola B, Harper JC, Sylvester CM, Lueken U, Veltman DJ, Winkler AM, Jahanshad N, Pine DS, Thompson PM, Stein DJ, and Van der Wee NJA
  • Molecular psychiatry [Mol Psychiatry] 2023 Mar; Vol. 28 (3), pp. 1079-1089. Date of Electronic Publication: 2023 Jan 19.
Subjects
Adult, Adolescent, Humans, Magnetic Resonance Imaging methods, Brain, Anxiety, Neuroimaging methods, and Phobia, Social
Abstract
There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = -0.077, p FWE  = 0.037; right: d = -0.104, p FWE  = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = -0.034, p FWE  = 0.045). Smaller bilateral putamen volumes (left: d = -0.141, p FWE  < 0.001; right: d = -0.158, p FWE  < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, p FWE  = 0.006; right: d = 0.099, p FWE  = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adolescence into adulthood.
(© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)

31. The Dutch Lung Cancer Audit-Radiotherapy (DLCA-R): Real-World Data on Stage III Non-Small Cell Lung Cancer Patients Treated With Curative Chemoradiation. [2023]

  • Dieleman E, van der Woude L, van Os R, van Bockel L, Coremans I, van Es C, De Jaeger K, Knol HP, Kolff W, Koppe F, Pomp J, Reymen B, Schinagl D, Spoelstra F, Tissing-Tan C, van der Voort van Zyp N, van der Wel A, Wijsman R, Dielwart M, Wiegman E, Damhuis R, and Belderbos J
  • Clinical lung cancer [Clin Lung Cancer] 2023 Mar; Vol. 24 (2), pp. 130-136. Date of Electronic Publication: 2022 Nov 25.
Subjects
Humans, Male, Aged, Infant, Neoplasm Staging, Chemoradiotherapy adverse effects, Carcinoma, Non-Small-Cell Lung drug therapy, Lung Neoplasms drug therapy, and Radiation Oncology
Abstract
Introduction: Chemoradiotherapy (CRT) is the standard of care in inoperable non-small-cell lung cancer (NSCLC) patients, favoring concurrent (cCRT) over sequential CRT (seqCRT), with adjuvant immunotherapy in responders. Elderly and frail NSCLC patients have generally been excluded from trials in the past. In elderly patients however, the higher treatment related morbidity of cCRT, may outweigh the possible lower tumor control of seqCRT. For elderly patients with locally advanced NSCLC real-world data is essential to be able to balance treatment toxicity and treatment outcome. The aim of this study is to analyze acute toxicity and 3-month mortality of curative chemoradiation (CRT) in patients with stage III NSCLC and to analyze whether cCRT for elderly stage III NSCLC patients is safe.
Methods: The Dutch Lung Cancer Audit-Radiotherapy (DLCA-R) is a national lung cancer audit that started in 2013 for patients treated with curative intent radiotherapy. All Dutch patients treated for stage III NSCLC between 2015 and 2018 with seqCRT or cCRT for (primary or recurrent) stage III lung cancer are included in this population-based study. Information was collected on patient, tumor- and treatment characteristics and the incidence and severity of acute non-hematological toxicity (CTCAE-4 version 4.03) and mortality within 3 months after the end of radiotherapy. To evaluate the association between prognostic factors and outcome (acute toxicity and mortality within 3 months), an univariable and multivariable analysis was performed. The definition of cCRT was:radiotherapy started within 30 days after the start of chemotherapy.
Results: Out of all 20 Dutch departments of radiation oncology, 19 centers participated in the registry. A total of 2942 NSCLC stage III patients were treated with CRT. Of these 67.2% (n = 1977) were treated with cCRT (median age 66 years) and 32.8% (n = 965) were treated with seqCRT (median age 69 years). Good performance status (WHO 0-1) was scored in 88.6% for patients treated with cCRT and in 71.0% in the patients treated with seqCRT. Acute nonhematological 3-month toxicity (CTCAE grade ≥3 or radiation pneumonitis grade ≥2) was scored in 21.9% of the patients treated with cCRT and in 17.7% of the patients treated with seqCRT. The univariable analysis for acute toxicity showed significantly increased toxicity for cCRT (P = .008), WHO ≥2 (P = .006), and TNM IIIC (P = .031). The multivariable analysis for acute toxicity was significant for cCRT (P = .015), WHO ≥2 (P = .001) and TNM IIIC (P = .016). The univariable analysis for 3-month mortality showed significance for seqCRT (P = .025), WHO ≥2 (P < .001), higher cumulative radiotherapy dose (P < .001), higher gross tumor volume total (P = .020) and male patients (p < .001). None of these variables reached significance in the multivariable analysis for 3-month mortality.
Conclusion: In this national lung cancer audit of inoperable NSCLC patients, 3-month toxicity was significantly higher in patients treated with cCRT (21.9% vs. 17.7% for seqCRT) higher TNM stage IIIC, and poor performance (WHO≥2) patients.The 3-months mortality was not significantly different for tested parameters. Age was not a risk factor for acute toxicity, nor 3 months mortality.
(Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)

32. Evaluation of left cardiac chamber function with cardiac magnetic resonance and association with outcome in patients with systemic sclerosis. [2023]

  • Butcher SC, Vos JL, Fortuni F, Galloo X, Liem SIE, Bax JJ, Delgado V, Vonk MC, van Leuven SI, Snoeren M, El Messaoudi S, de Vries-Bouwstra JK, Nijveldt R, and Ajmone Marsan N
  • Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2023 Feb 06; Vol. 62 (SI), pp. SI20-SI31.
Subjects
Female, Humans, Male, Contrast Media, Gadolinium, Magnetic Resonance Imaging, Cine, Magnetic Resonance Spectroscopy, Predictive Value of Tests, Prognosis, Stroke Volume, Ventricular Function, Left, Middle Aged, Heart Failure, Scleroderma, Systemic complications, and Scleroderma, Systemic diagnostic imaging
Abstract
Objective: This study aimed to determine whether lower values of feature-tracking cardiovascular magnetic resonance (CMR)-derived left atrial reservoir strain (LARS) and impaired left ventricular (LV) global longitudinal strain (GLS) were associated with the presence of symptoms and long-term prognosis in patients with SSc.
Methods: A total of 100 patients {54 [interquartile range (IQR) 46-64] years, 42% male} with SSc who underwent CMR imaging at two tertiary referral centres were included. All patients underwent analysis of LARS and LV GLS using feature-tracking on CMR and were followed-up for the occurrence of all-cause mortality.
Results: The median LV GLS was -21.8% and the median LARS was 36%. On multivariable logistic regression, LARS [odds ratio (OR) 0.964 per %, 95% CI 0.929, 0.998, P = 0.049] was independently associated with New York Heart Association (NYHA) class II-IV heart failure symptoms. Over a median follow-up of 37 (21-62) months, a total of 24 (24%) patients died. Univariable Cox regression analysis demonstrated that LARS [hazard ratio (HR) 0.94 per 1%, 95% CI 0.91, 0.97, P < 0.0001) and LV GLS (HR 1.10 per %, 95% CI 1.03, 1.17, P = 0.005) were associated with all-cause mortality, while LV ejection fraction was not. Likelihood ratio tests demonstrated that LARS provided incremental value over prognostically important clinical and imaging parameters, including late gadolinium enhancement.
Conclusion: In patients with SSc, LARS was independently associated with the presence of NYHA class II-IV heart failure symptoms. Although both LARS and LV GLS were associated with all-cause mortality, only LARS provided incremental value over all evaluated variables known to be prognostically important in patients with SSc.
(© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.)

33. A phase 1b study of venetoclax and azacitidine combination in patients with relapsed or refractory myelodysplastic syndromes. [2023]

  • Zeidan AM, Borate U, Pollyea DA, Brunner AM, Roncolato F, Garcia JS, Filshie R, Odenike O, Watson AM, Krishnadasan R, Bajel A, Naqvi K, Zha J, Cheng WH, Zhou Y, Hoffman D, Harb JG, Potluri J, and Garcia-Manero G
  • American journal of hematology [Am J Hematol] 2023 Feb; Vol. 98 (2), pp. 272-281. Date of Electronic Publication: 2022 Nov 10.
Subjects
Aged, Humans, Male, Azacitidine therapeutic use, Leukemia, Myeloid, Acute drug therapy, Neutropenia chemically induced, Sulfonamides, Treatment Outcome, Female, Antineoplastic Combined Chemotherapy Protocols adverse effects, and Myelodysplastic Syndromes drug therapy
Abstract
Patients with relapsed/refractory (R/R) higher-risk myelodysplastic syndromes (MDS) have a dismal median overall survival (OS) after failing hypomethylating agent (HMA) treatment. There is no standard of care for patients after HMA therapy failure; hence, there is a critical need for effective therapeutic strategies. Herein, we present the safety and efficacy of venetoclax + azacitidine in patients with R/R MDS. This phase 1b, open-label, multicenter study enrolled patients ≥18 years. Patients were treated with escalating doses of oral venetoclax: 100, 200, or 400 mg daily for 14 days every 28-day cycle. Azacitidine was administered on Days 1-7 every cycle at 75 mg/m 2 /day intravenously/subcutaneously. Responses were assessed per modified 2006 International Working Group (IWG) criteria. Forty-four patients (male 86%, median age 74 years) received venetoclax + azacitidine treatment. Median follow-up was 21.2 months. Hematological adverse events of Grade ≥ 3 included febrile neutropenia (34%), thrombocytopenia (32%), neutropenia (27%), and anemia (18%). Pneumonia (23%) was the most common Grade ≥ 3 infection. Marrow responses were seen including complete remission (CR, n = 3, 7%) and marrow CR (mCR, n = 14, 32%); 36% (16/44) achieved transfusion independence (TI) for RBCs and/or platelets, and 43% (6/14) with mCR achieved hematological improvement (HI). The median time to CR/mCR was 1.2 months, and the median duration of response for CR + mCR was 8.6 months. Median OS was 12.6 months. Venetoclax + azacitidine shows activity in patients with R/R MDS following prior HMA therapy failure and provides clinically meaningful benefits, including HI and TI, and encouraging OS.
(© 2022 The Authors. American Journal of Hematology published by Wiley Periodicals LLC.)

34. Transnational Trans Woman Inspires and Informs Evidence-Informed Interventions. [2023]

  • Cruzado-Quiñones J, Huibregtse RC, and Jordan AO
  • Journal of correctional health care : the official journal of the National Commission on Correctional Health Care [J Correct Health Care] 2023 Feb; Vol. 29 (1), pp. 19-26. Date of Electronic Publication: 2023 Jan 25.
Subjects
Female, Humans, New York City, Puerto Rico, Transgender Persons, Male, Hispanic or Latino, and Health Services for Transgender Persons
Abstract
Transitional Care Coordination is an evidence-informed model program developed by New York City Correctional Health Services as a Health Resources and Services Administration Special Projects of National Significance Correctional Health Linkage Intervention. Using implementation science under this and subsequent demonstration projects, interventions were adapted and enhanced to address the transitional needs of people of Puerto Rican ancestry and to expand the network of care across the islands of Puerto Rico. These interventions were informed, in part, by a transnational trans woman of color of Puerto Rican ancestry living with HIV. A socioecological model framework and case study are used to illustrate how evidence-informed interventions are developed and adapted to address the needs of those served.

35. PASC in Solid Organ Transplant Recipients With Self-reported SARS-CoV-2 Infection. [2023]

  • Alasfar S, Chiang TP, Snyder AJ, Ou MT, Boyarsky BJ, Abedon AT, Alejo JL, Cook S, Cochran W, Brigham E, Parker AM, Garonzik-Wang J, Massie AB, Brennan DC, Vannorsdall T, Segev DL, and Avery RK
  • Transplantation [Transplantation] 2023 Jan 01; Vol. 107 (1), pp. 181-191. Date of Electronic Publication: 2022 Sep 19.
Subjects
Humans, Self Report, SARS-CoV-2, Quality of Life, COVID-19 Testing, Transplant Recipients, Cough, Pain, COVID-19 epidemiology, and Organ Transplantation adverse effects
Abstract
Background: Postacute sequelae of SARS-CoV-2 infection (PASC) is an increasingly recognized phenomenon and manifested by long-lasting cognitive, mental, and physical symptoms beyond the acute infection period. We aimed to estimate the frequency of PASC symptoms in solid organ transplant (SOT) recipients and compared their frequency between those with SARS-CoV-2 infection requiring hospitalization and those who did not require hospitalization.
Methods: A survey consisting of 7 standardized questionnaires was administered to 111 SOT recipients with history of SARS-CoV-2 infection diagnosed >4 wk before survey administration.
Results: Median (interquartile range) time from SARS-CoV-2 diagnosis was 167 d (138-221). Hospitalization for SARS-CoV-2 infection was reported in 33 (30%) participants. Symptoms after the COVID episode were perceived as following: significant trauma (53%), cognitive decline (50%), fatigue (41%), depression (36%), breathing problems (35%), anxiety (23%), dysgeusia (22%), dysosmia (21%), and pain (19%). Hospitalized patients had poorer median scores in cognition (Quick Dementia Rating System survey score: 2.0 versus 0.5, P = 0.02), quality of life (Health-related Quality of Life survey: 2.0 versus 1.0, P = 0.015), physical health (Global physical health scale: 10.0 versus 11.0, P = 0.005), respiratory status (Breathlessness, Cough and Sputum Scale: 1.0 versus 0.0, P = 0.035), and pain (Pain score: 3 versus 0 out of 10, P = 0.003). Among patients with infection >6 mo prior, some symptoms were still present as following: abnormal breathing (42%), cough (40%), dysosmia (29%), and dysgeusia (34%).
Conclusions: SOT recipients reported a high frequency of PASC symptoms. Multidisciplinary approach is needed to care for these patients beyond the acute phase.
(Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)

36. 6-month antibody kinetics and durability after four doses of a SARS-CoV-2 vaccine in solid organ transplant recipients. [2023]

  • Mitchell J, Chiang TP, Alejo JL, Kim JD, Chang A, Abedon AT, Avery RK, Tobian AAR, Levan ML, Warren DS, Garonzik-Wang JM, Segev DL, Massie AB, and Werbel WA
  • Clinical transplantation [Clin Transplant] 2023 Jan; Vol. 37 (1), pp. e14868. Date of Electronic Publication: 2022 Dec 07.
Subjects
Humans, COVID-19 Vaccines, Kinetics, SARS-CoV-2, Antibodies, Transplant Recipients, Antibodies, Viral, COVID-19 epidemiology, COVID-19 prevention control, and Organ Transplantation

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38. Vergence/accommodative therapy for symptomatic convergence insufficiency in children: Time course of improvements in convergence function [2023]

  • Jenewein, Erin C., Cotter, Susan, Roberts, Tawna, Kulp, Marjean, Mitchell, G. Lynn, Jones-Jordan, Lisa A., Chen, Angela M., Hopkins, Kristine, Huang, Kristine, Amster, Deborah, Fecho, Gregory, Tyler, Julie, Meiyeppen, Shivakhaami, Scheiman, Mitchell, Scheiman, Mitchell, Cooper, Jeffrey, Schulman, Erica, Hamian, Kimberly, Iacono, Danielle, Larson, Steven, Leung, Valerie, Meeder, Sara, Ramos, Elaine, Ritter, Steven, Steiner, Audra, Stormann, Alexandria, Vricella, Marilyn, Zhu, Xiaoying, Tamkins, Susanna, Aguilera, Naomi, Brafman, Elliot, Capo, Hilda, Cavuoto, Kara, Crespo, Isaura, Dowling, Monica, Draskovic, Kristie, Farag, Miriam, Fischer, Vicky, Grace, Sara, Gutierrez, Ailen, Manchola-Orozco, Carolina, Martinez, Maria, McKeown, Craig, Osigian, Carla, Pham, Tuyet-Suong, Small, Leslie, Townsend, Natalie, Gallaway, Michael, Boas, Mark, Calvert, Christine, Franz, Tara, Gerrouge, Amanda, Hayden, Donna, Margolies, Zachary, Myung, Jenny, Pollack, Karen, Shoge, Ruth, Tang, Andrew, Tannen, Noah, Trieu, Lynn, Trujillo, Luis, Buckland, Michelle, Ellis, Allison, Fogt, Jennifer, McDaniel, Catherine, McGann, Taylor, Morrison, Ann, Mulvihill, Shane, Peiffer, Adam, Plaumann, Maureen, Pierce, Gil, Preston, Julie, Reuter, Kathleen, Stevens, Nancy, Teeny, Jake, Toole, Andrew, Widmer, Douglas, Zimmerman, Aaron, Barnhardt, Carmen, Borsting, Eric, Chu, Raymond, Parker, Susan, Retnasothie, Dashaini, Wu, Judith, Hertle, Richard, Clark, Penny, Culp, Kelly, Fraley, Kathy, Grant, Drusilla, Hanna, Nancy, Knox, Stephanie, Lawhon, William, Li, Lan, Mitcheff, Sarah, Ricker, Isabel, Solis, Casandra, Wall, Palak, Zaczyk, Samantha, Marsh-Tootle, Wendy, Bowen, Michelle, Call, Terri, Domnanovich, Kristy, Frazier, Marcela, Guyette, Nicole, Hayes, Oakley, Houser, John, Lee, Sarah, Montejo, Jenifer, Oechslin, Tamara, Turner, Candace, Weise, Katherine, Coulter, Rachel, Bade, Annette, Bansal, Surbhi, Falco, Laura, Green, Katherine, Irizarry, Gabriela, Jhajj, Jasleen, Patterson, Nicole, Rodena, Jacqueline, Tea, Yin, Weiss, Dana, Zakaib, Lauren, Lorenzana, Ingryd, Meza, Yesena, Mann, Ryan, Quezada, Mariana, Rein, Scott, Rudaitis, Indre, Stepleton, Susan, Wajs, Beata, Redford, Maryann, Hertle, Richard, Redford, Maryann, Denton, Carolyn, Arnold, Eugene, Borsting, Eric, Chase, Christopher, Denton, Carolyn, Wee, Sharyl, Dahl-Leonard, Katlynn, Powers, Kenneth, Alaniz, Amber, Diener-West, Marie, Good, William V., Grisham, David, Kratochvil, Christopher J., Revicki, Dennis, Wanzek, Jeanne, Pollack, Karen, Abraham, Mustafa, Dangelo, Julianne, Hegedus, Jordan, Jones, Ian, Junglas, Alexander, Lee, Jihyun, Nettles, Jadin, Mitchell, Curtis, Osman, Mawada, Scott-Tibbs, Gloria, Sinnott, Loraine, Teasley, Chloe, Vang, Victor, and Varghese, Robin
  • Ophthalmic and Physiological Optics. January, 2023, Vol. 43 Issue 1, p105, 11 p.

39. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. [2022]

  • Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Wang Z, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Havulinna AS, Veturi Y, Pacheco JA, Rosenthal EA, Lingren T, Feng Q, Kullo IJ, Narita A, Takayama J, Martin HC, Hunt KA, Trivedi B, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Rasheed A, Hindy G, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Choudhury A, Sengupta D, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Wood AR, Ji Y, Gao Z, Haworth S, Yousri NA, Mitchell RE, Chai JF, Aadahl M, Bjerregaard AA, Yao J, Manichaikul A, Hwu CM, Hung YJ, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Sabater-Lleal M, Noordam R, Mauro P, Matteo F, McDaid AF, Marques-Vidal P, Wielscher M, Trompet S, Sattar N, Møllehave LT, Munz M, Zeng L, Huang J, Yang B, Poveda A, Kurbasic A, Lamina C, Forer L, Scholz M, Galesloot TE, Bradfield JP, Ruotsalainen SE, Daw E, Zmuda JM, Mitchell JS, Fuchsberger C, Christensen H, Brody JA, Vazquez-Moreno M, Feitosa MF, Wojczynski MK, Wang Z, Preuss MH, Mangino M, Christofidou P, Verweij N, Benjamins JW, Engmann J, Tsao NL, Verma A, Slieker RC, Lo KS, Zilhao NR, Le P, Kleber ME, Delgado GE, Huo S, Ikeda DD, Iha H, Yang J, Liu J, Demirkan A, Leonard HL, Marten J, Frank M, Schmidt B, Smyth LJ, Cañadas-Garre M, Wang C, Nakatochi M, Wong A, Hutri-Kähönen N, Sim X, Xia R, Huerta-Chagoya A, Fernandez-Lopez JC, Lyssenko V, Nongmaithem SS, Bayyana S, Stringham HM, Irvin MR, Oldmeadow C, Kim HN, Ryu S, Timmers PRHJ, Arbeeva L, Dorajoo R, Lange LA, Prasad G, Lorés-Motta L, Pauper M, Long J, Li X, Theusch E, Takeuchi F, Spracklen CN, Loukola A, Bollepalli S, Warner SC, Wang YX, Wei WB, Nutile T, Ruggiero D, Sung YJ, Chen S, Liu F, Yang J, Kentistou KA, Banas B, Nardone GG, Meidtner K, Bielak LF, Smith JA, Hebbar P, Farmaki AE, Hofer E, Lin M, Concas MP, Vaccargiu S, van der Most PJ, Pitkänen N, Cade BE, van der Laan SW, Chitrala KN, Weiss S, Bentley AR, Doumatey AP, Adeyemo AA, Lee JY, Petersen ERB, Nielsen AA, Choi HS, Nethander M, Freitag-Wolf S, Southam L, Rayner NW, Wang CA, Lin SY, Wang JS, Couture C, Lyytikäinen LP, Nikus K, Cuellar-Partida G, Vestergaard H, Hidalgo B, Giannakopoulou O, Cai Q, Obura MO, van Setten J, Li X, Liang J, Tang H, Terzikhan N, Shin JH, Jackson RD, Reiner AP, Martin LW, Chen Z, Li L, Kawaguchi T, Thiery J, Bis JC, Launer LJ, Li H, Nalls MA, Raitakari OT, Ichihara S, Wild SH, Nelson CP, Campbell H, Jäger S, Nabika T, Al-Mulla F, Niinikoski H, Braund PS, Kolcic I, Kovacs P, Giardoglou T, Katsuya T, de Kleijn D, de Borst GJ, Kim EK, Adams HHH, Ikram MA, Zhu X, Asselbergs FW, Kraaijeveld AO, Beulens JWJ, Shu XO, Rallidis LS, Pedersen O, Hansen T, Mitchell P, Hewitt AW, Kähönen M, Pérusse L, Bouchard C, Tönjes A, Chen YI, Pennell CE, Mori TA, Lieb W, Franke A, Ohlsson C, Mellström D, Cho YS, Lee H, Yuan JM, Koh WP, Rhee SY, Woo JT, Heid IM, Stark KJ, Zimmermann ME, Völzke H, Homuth G, Evans MK, Zonderman AB, Polasek O, Pasterkamp G, Hoefer IE, Redline S, Pahkala K, Oldehinkel AJ, Snieder H, Biino G, Schmidt R, Schmidt H, Bandinelli S, Dedoussis G, Thanaraj TA, Kardia SLR, Peyser PA, Kato N, Schulze MB, Girotto G, Böger CA, Jung B, Joshi PK, Bennett DA, De Jager PL, Lu X, Mamakou V, Brown M, Caulfield MJ, Munroe PB, Guo X, Ciullo M, Jonas JB, Samani NJ, Kaprio J, Pajukanta P, Tusié-Luna T, Aguilar-Salinas CA, Adair LS, Bechayda SA, de Silva HJ, Wickremasinghe AR, Krauss RM, Wu JY, Zheng W, Hollander AI, Bharadwaj D, Correa A, Wilson JG, Lind L, Heng CK, Nelson AE, Golightly YM, Wilson JF, Penninx B, Kim HL, Attia J, Scott RJ, Rao DC, Arnett DK, Hunt SC, Walker M, Koistinen HA, Chandak GR, Mercader JM, Costanzo MC, Jang D, Burtt NP, Villalpando CG, Orozco L, Fornage M, Tai E, van Dam RM, Lehtimäki T, Chaturvedi N, Yokota M, Liu J, Reilly DF, McKnight AJ, Kee F, Jöckel KH, McCarthy MI, Palmer CNA, Vitart V, Hayward C, Simonsick E, van Duijn CM, Jin ZB, Qu J, Hishigaki H, Lin X, März W, Gudnason V, Tardif JC, Lettre G, Hart LM', Elders PJM, Damrauer SM, Kumari M, Kivimaki M, van der Harst P, Spector TD, Loos RJF, Province MA, Parra EJ, Cruz M, Psaty BM, Brandslund I, Pramstaller PP, Rotimi CN, Christensen K, Ripatti S, Widén E, Hakonarson H, Grant SFA, Kiemeney LALM, de Graaf J, Loeffler M, Kronenberg F, Gu D, Erdmann J, Schunkert H, Franks PW, Linneberg A, Jukema JW, Khera AV, Männikkö M, Jarvelin MR, Kutalik Z, Francesco C, Mook-Kanamori DO, van Dijk KW, Watkins H, Strachan DP, Grarup N, Sever P, Poulter N, Chuang LM, Rotter JI, Dantoft TM, Karpe F, Neville MJ, Timpson NJ, Cheng CY, Wong TY, Khor CC, Li H, Sabanayagam C, Peters A, Gieger C, Hattersley AT, Pedersen NL, Magnusson PKE, Boomsma DI, Willemsen AHM, Cupples L, van Meurs JBJ, Ghanbari M, Gordon-Larsen P, Huang W, Kim YJ, Tabara Y, Wareham NJ, Langenberg C, Zeggini E, Kuusisto J, Laakso M, Ingelsson E, Abecasis G, Chambers JC, Kooner JS, de Vries PS, Morrison AC, Hazelhurst S, Ramsay M, North KE, Daviglus M, Kraft P, Martin NG, Whitfield JB, Abbas S, Saleheen D, Walters RG, Holmes MV, Black C, Smith BH, Baras A, Justice AE, Buring JE, Ridker PM, Chasman DI, Kooperberg C, Tamiya G, Yamamoto M, van Heel DA, Trembath RC, Wei WQ, Jarvik GP, Namjou B, Hayes MG, Ritchie MD, Jousilahti P, Salomaa V, Hveem K, Åsvold BO, Kubo M, Kamatani Y, Okada Y, Murakami Y, Kim BJ, Thorsteinsdottir U, Stefansson K, Zhang J, Chen Y, Ho YL, Lynch JA, Rader DJ, Tsao PS, Chang KM, Cho K, O'Donnell CJ, Gaziano JM, Wilson PWF, Frayling TM, Hirschhorn JN, Kathiresan S, Mohlke KL, Sun YV, Morris AP, Boehnke M, Brown CD, Natarajan P, Deloukas P, Willer CJ, Assimes TL, and Peloso GM
  • Genome biology [Genome Biol] 2022 Dec 27; Vol. 23 (1), pp. 268. Date of Electronic Publication: 2022 Dec 27.
Subjects
Humans, Sex Characteristics, Phenotype, Lipids genetics, Polymorphism, Single Nucleotide, Genetic Pleiotropy, Genome-Wide Association Study, and Genetic Predisposition to Disease
Abstract
Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.
Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.
Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
(© 2022. The Author(s).)

40. Genetic diversity fuels gene discovery for tobacco and alcohol use [2022]

  • Saunders, Gretchen R. B., Wang, Xingyan, Chen, Fang, Jang, Seon-Kyeong, Liu, Mengzhen, Wang, Chen, Gao, Shuang, Jiang, Yu, Khunsriraksakul, Chachrit, Otto, Jacqueline M., Addison, Clifton, Akiyama, Masato, Albert, Christine M., Aliev, Fazil, Alonso, Alvaro, Arnett, Donna K., Ashley-Koch, Allison E., Ashrani, Aneel A., Barnes, Kathleen C., Barr, R. Graham, Bartz, Traci M., Becker, Diane M., Bielak, Lawrence F., Benjamin, Emelia J., Bis, Joshua C., Bjornsdottir, Gyda, Blangero, John, Bleecker, Eugene R., Boardman, Jason D., Boerwinkle, Eric, Boomsma, Dorret I., Boorgula, Meher Preethi, Bowden, Donald W., Brody, Jennifer A., Cade, Brian E., Chasman, Daniel I., Chavan, Sameer, Chen, Yii-Der Ida, Chen, Zhengming, Cheng, Iona, Cho, Michael H., Choquet, Hélène, Cole, John W., Cornelis, Marilyn C., Cucca, Francesco, Curran, Joanne E., de Andrade, Mariza, Dick, Danielle M., Docherty, Anna R., Duggirala, Ravindranath, Eaton, Charles B., Ehringer, Marissa A., Esko, Tõnu, Faul, Jessica D., Fernandes Silva, Lilian, Fiorillo, Edoardo, Fornage, Myriam, Freedman, Barry I., Gabrielsen, Maiken E., Garrett, Melanie E., Gharib, Sina A., Gieger, Christian, Gillespie, Nathan, Glahn, David C., Gordon, Scott D., Gu, Charles C., Gu, Dongfeng, Gudbjartsson, Daniel F., Guo, Xiuqing, Haessler, Jeffrey, Hall, Michael E., Haller, Toomas, Harris, Kathleen Mullan, He, Jiang, Herd, Pamela, Hewitt, John K., Hickie, Ian, Hidalgo, Bertha, Hokanson, John E., Hopfer, Christian, Hottenga, JoukeJan, Hou, Lifang, Huang, Hongyan, Hung, Yi-Jen, Hunter, David J., Hveem, Kristian, Hwang, Shih-Jen, Hwu, Chii-Min, Iacono, William, Irvin, Marguerite R., Jee, Yon Ho, Johnson, Eric O., Joo, Yoonjung Y., Jorgenson, Eric, Justice, Anne E., Kamatani, Yoichiro, Kaplan, Robert C., Kaprio, Jaakko, Kardia, Sharon L. R., Keller, Matthew C., Kelly, Tanika N., Kooperberg, Charles, Korhonen, Tellervo, Kraft, Peter, Krauter, Kenneth, Kuusisto, Johanna, Laakso, Markku, Lasky-Su, Jessica, Lee, Wen-Jane, Lee, James J., Levy, Daniel, Li, Liming, Li, Kevin, Li, Yuqing, Lin, Kuang, Lind, Penelope A., Liu, Chunyu, Lloyd-Jones, Donald M., Lutz, Sharon M., Ma, Jiantao, Mägi, Reedik, Manichaikul, Ani, Martin, Nicholas G., Mathur, Ravi, Matoba, Nana, McArdle, Patrick F., McGue, Matt, McQueen, Matthew B., Medland, Sarah E., Metspalu, Andres, Meyers, Deborah A., Millwood, Iona Y., Mitchell, Braxton D., Mohlke, Karen L., Moll, Matthew, Montasser, May E., Morrison, Alanna C., Mulas, Antonella, Nielsen, Jonas B., North, Kari E., Oelsner, Elizabeth C., Okada, Yukinori, Orrù, Valeria, Palmer, Nicholette D., Palviainen, Teemu, Pandit, Anita, Park, S. Lani, Peters, Ulrike, Peters, Annette, Peyser, Patricia A., Polderman, Tinca J. C., Rafaels, Nicholas, Redline, Susan, Reed, Robert M., Reiner, Alex P., Rice, John P., Rich, Stephen S., Richmond, Nicole E., Roan, Carol, Rotter, Jerome I., Rueschman, Michael N., Runarsdottir, Valgerdur, Saccone, Nancy L., Schwartz, David A., Shadyab, Aladdin H., Shi, Jingchunzi, Shringarpure, Suyash S., Sicinski, Kamil, Skogholt, Anne Heidi, Smith, Jennifer A., Smith, Nicholas L., Sotoodehnia, Nona, Stallings, Michael C., Stefansson, Hreinn, Stefansson, Kari, Stitzel, Jerry A., Sun, Xiao, Syed, Moin, Tal-Singer, Ruth, Taylor, Amy E., Taylor, Kent D., Telen, Marilyn J., Thai, Khanh K., Tiwari, Hemant, Turman, Constance, Tyrfingsson, Thorarinn, Wall, Tamara L., Walters, Robin G., Weir, David R., Weiss, Scott T., White, Wendy B., Whitfield, John B., Wiggins, Kerri L., Willemsen, Gonneke, Willer, Cristen J., Winsvold, Bendik S., Xu, Huichun, Yanek, Lisa R., Yin, Jie, Young, Kristin L., Young, Kendra A., Yu, Bing, Zhao, Wei, Zhou, Wei, Zöllner, Sebastian, Zuccolo, Luisa, Batini, Chiara, Bergen, Andrew W., Bierut, Laura J., David, Sean P., Gagliano Taliun, Sarah A., Hancock, Dana B., Jiang, Bibo, Munafò, Marcus R., Thorgeirsson, Thorgeir E., Liu, Dajiang J., and Vrieze, Scott
  • Nature; December 2022, Vol. 612 Issue: 7941 p720-724, 5p
Abstract
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury1–4. These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries5. Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction.

41. Cardiovascular magnetic resonance-derived left ventricular intraventricular pressure gradients among patients with precapillary pulmonary hypertension. [2022]

  • Vos JL, Leiner T, van Dijk APJ, Pedrizzetti G, Alenezi F, Rodwell L, van der Wegen CTPM, Post MC, Driessen MMP, and Nijveldt R
  • European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2022 Dec 19; Vol. 24 (1), pp. 78-87.
Subjects
Humans, Ventricular Pressure, Cross-Sectional Studies, Heart Ventricles, Ventricular Function, Left, Stroke Volume, Magnetic Resonance Spectroscopy, Hypertension, Pulmonary, and Ventricular Dysfunction, Left
Abstract
Aims: Precapillary pulmonary hypertension (pPH) affects left ventricular (LV) function by ventricular interdependence. Since LV ejection fraction (EF) is commonly preserved, LV dysfunction should be assessed with more sensitive techniques. Left atrial (LA) strain and estimation of LV intraventricular pressure gradients (IVPG) may be valuable in detecting subtle changes in LV mechanics; however, the value of these techniques in pPH is unknown. Therefore, the aim of our study is to evaluate LA strain and LV-IVPGs from cardiovascular magnetic resonance (CMR) cines in pPH patients.
Methods and Results: In this cross-sectional study, 31 pPH patients and 22 healthy volunteers underwent CMR imaging. Feature-tracking LA strain was measured on four- and two-chamber cines. LV-IVPGs (from apex-base) are computed from a formulation using the myocardial movement and velocity of the reconstructed 3D-LV (derived from long-axis cines using feature-tracking). Systolic function, both LV EF and systolic ejection IVPG, was preserved in pPH patients. Compared to healthy volunteers, diastolic function was impaired in pPH patients, depicted by (i) lower LA reservoir (36 ± 7% vs. 26 ± 9%, P < 0.001) and conduit strain (26 ± 6% vs. 15 ± 8%, P < 0.001) and (ii) impaired diastolic suction (-9.1 ± 3.0 vs. ‒6.4 ± 4.4, P = 0.02) and E-wave decelerative IVPG (8.9 ± 2.6 vs. 5.7 ± 3.1, P < 0.001). Additionally, 11 pPH patients (35%) showed reversal of IVPG at systolic-diastolic transition compared to none of the healthy volunteers (P = 0.002).
Conclusions: pPH impacts LV function by altering diastolic function, demonstrated by an impairment of LA phasic function and LV-IVPG analysis. These parameters could therefore potentially be used as early markers for LV functional decline in pPH patients.
Competing Interests: Conflict of interest: none declared.
(© Crown copyright 2022.)

42. Circulating adipose tissue proteins involved in atrial fibrillation: An explorative scoping review. [2022]

  • Meulendijks ER, Krul SPJ, Baalman SW, de Vries TAC, Wesselink R, Ernault AC, Kawasaki M, Al-Shama R, Neefs J, Limpens J, and de Groot JR
  • Trends in cardiovascular medicine [Trends Cardiovasc Med] 2022 Dec 17. Date of Electronic Publication: 2022 Dec 17.
Abstract
Obesity increases the risk of atrial fibrillation (AF), potentially through proteins secreted by adipose tissue (AT) that affect atrial electrical and structural remodeling. We aim to give a comprehensive overview of circulating AT proteins involved in inflammation and fibrosis, that are associated with prevalent AF (paroxysmal or persistent) and the risk on developing new-onset AF. These include adipokines, defined as proteins enriched in AT as adiponectin, but also proteins less specific to AT. We systematically performed an explorative search for studies reporting associations between proteins secreted from cells residing in the AT and AF, and additionally assessed the effect of obesity on these proteins by a secondary search. The AT proteins involved in inflammation were mostly increased in patients with prevalent and new-onset AF, and with obesity, while the AT enriched adipokines were mostly not associated with AF. This review provides insight into circulating adipose tissue proteins involved in AF substrate formation.
(Copyright © 2022. Published by Elsevier Inc.)

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44. PART is part of SNAP‐MCI. [2022]

  • Wisse, Laura EM, Xie, Long, Lyu, Xueying, Das, Sandhitsu R., de Flores, Robin, Lane, Jacqueline, Yushkevich, Paul A., Wolk, David A., and Initiative, Disease Neuroimaging
  • Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2022 Supplement 6, Vol. 18 Issue 6, p1-4, 4p
Abstract
Background: Mild Cognitive Impairment with Suspected non‐Alzheimer's Pathophysiology (SNAP‐MCI) represents a group of patients with Alzheimer's disease (AD) like neurodegeneration without beta‐amyloid pathology. While this group likely has a heterogeneous etiology, tau pathology, as in Primary Age‐Related Tauopathy (PART), has been hypothesized to play a major role. We investigate tau positron emission tomography (PET) uptake in the medial temporal lobe (MTL) in SNAP‐MCI and the association of MTL Tau‐PET uptake with structural measures and delayed recall in beta‐amyloid negative (A‐) MCI patients. Method: 237 MCI patients and 301 A‐ controls with available beta‐amyloid and tau PET and magnetic resonance images (within 200 days) were included. Baseline hippocampal volume and entorhinal cortex (ERC) and Brodmann areas (BA)35 thickness were obtained using an in‐house developed pipeline and annualized atrophy rates were estimated in an unbiased fashion using follow‐up MRIs within 4.5 years. Βeta‐amyloid status (A+/‐) was determined by a standard cut‐off (Florbetapir: 1.11; Florbetaben: 1.08) and neurodegeneration status (N+/‐) by hippocampal volumes, corrected for intracranial volume, using the 90th percentile of A+ AD patients as the cut‐off. Tau‐PET standardized uptake value ratio (SUVR) in the ERC/BA35 was calculated. A composite z‐score of delayed recall at baseline and change over 2 years was obtained. Result: SNAP‐MCI had significantly higher ERC/BA35 Tau‐PET SUVR than A‐ controls (Table 1, corrected for age) and qualitatively higher than A‐N‐ MCI (p=0.10). ERC/BA35 Tau‐PET SUVR in A‐N‐ MCI was not significantly different from A‐ controls. In A‐ MCI patients, ERC/BA35 Tau‐PET SUVR was significantly associated with BA35 thickness and hippocampal, ERC and BA35 atrophy rates, corrected for beta‐amyloid PET SUVR (Table 2; Figure 1). MTL structural measures, but not ERC/BA35 Tau‐PET SUVR, were associated with cross‐sectional and longitudinal delayed recall measures (Table 3; Figure 2). Conclusion: SNAP‐MCI had elevated ERC/BA35 Tau‐PET SUVR and ERC/BA35 Tau‐PET SUVR was associated with MTL structural measures in A‐ MCI patients. This indicates that tau pathology might be an important driver of neurodegeneration in the absence of beta‐amyloid pathology, supporting the notion that PART contributes to SNAP‐MCI. Additionally, MTL structure was associated with memory performance, consistent with SNAP not being a benign condition. [ABSTRACT FROM AUTHOR]

45. Drug therapy, imaging, and other aspects of clinical management change after Alzheimer's biomarker testing in routine practice: Findings from the IMPACT‐AD BC study. [2022]

  • Yang, David, Best, John R., Chambers, Colleen, Feldman, Howard H., Pettersen, Jacqueline A, Henri‐Bhargava, Alexander, Lee, Philip E, Nygaard, Haakon B., Funnell, Clark R, Foti, Dean J, Hsiung, Ging‐Yuek Robin, and DeMarco, Mari L.
  • Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2022 Supplement 6, Vol. 18 Issue 6, p1-2, 2p
Abstract
Background: While previous studies have demonstrated the effect of Alzheimer's disease (AD) CSF testing in changing diagnosis, we lack an understanding of how this testing affects clinical management. Therefore, we assessed changes in clinical management associated with AD CSF biomarker testing when ordered as part of routine clinical management. Method: The 'Investigating the Impact of Alzheimer's Disease Diagnostics in British Columbia' (IMPACT‐AD BC) study (NCT05002699) is a longitudinal study examining the impact of AD CSF testing on clinical management, personal utility and health care economics in British Columbia, Canada. After AD CSF testing was ordered as part of routine care (where the clinical scenario met the appropriate use criteria), the patient and their physician were eligible to participate in the study. The primary outcome was the change in management (pre‐ v. post‐biomarker results) in a composite measure including 1) AD drug therapy, 2) other relevant drug therapy, 3) other diagnostic procedures, and 4) referral or counselling. Result: Participants (n = 129) had a median age of 63 (IQR:58‐68); 49% were female. Cognitive impairment at baseline consisted of 7% with subjective cognitive impairment, 53% with mild cognitive impairment, and 40% with dementia. CSF biomarker profiles were consistent with an amyloid‐beta pathology (i.e., A+) in 72% of cases. Changes in clinical management because of testing occurred in 83% of cases including: referrals and counseling (57%), imaging (47%) and other diagnostic procedures (e.g., neuropsychological testing) (42%), and use of AD drug therapies (40%). For those with a non‐AD pre‐biomarkers diagnosis, 42% were changed to AD post‐biomarkers; for those with an AD pre‐biomarkers diagnosis, 18% were changed to non‐AD post‐biomarkers. Conclusion: This study has revealed substantial changes in clinical management as a direct result of AD CSF biomarker testing in routine care. An understanding of the implications of biomarker testing will in turn help us: improve appropriate utilization, understand the broader impacts on persons living with dementia and on the health care system, and prepare for expanded use of this testing with the availability of disease‐modifying therapeutics. [ABSTRACT FROM AUTHOR]

46. Reply: Further Insights Into the Prognostic Value of Left Atrial Strain in Dilated Cardiomyopathy? [2022]

  • Raafs AG, Henkens MTHM, Vos JL, Nijveldt R, and Verdonschot JAJ
  • JACC. Cardiovascular imaging [JACC Cardiovasc Imaging] 2022 Dec; Vol. 15 (12), pp. 2156-2157.
Subjects
Humans, Prognosis, Predictive Value of Tests, Cardiomyopathy, Dilated diagnostic imaging, Atrial Fibrillation, and Atrial Appendage

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48. Incidence of VTE in Pregnant Women with Sickle Cell Gene Mutation(s): A Retrospective Database Analysis [2022]

  • Shaukat, Rimsha, Le Blanc, Kimberly, Brown, Tyiesha Sharron, Robin, Alida, Martinez, Shidestini, Walton, Jacqueline, Gutta, Pranavteja, Shi, Runhua, Master, Samip R, and Mansour, Richard Preston
  • Blood; November 2022, Vol. 140 Issue: 1, Number 1 Supplement 1 p2556-2557, 2p

49. Ruxolitinib and exemestane for estrogen receptor positive, aromatase inhibitor resistant advanced breast cancer. [2022]

  • Makhlin I, McAndrew NP, Wileyto EP, Clark AS, Holmes R, Bottalico LN, Mesaros C, Blair IA, Jeschke GR, Fox KR, Domchek SM, Matro JM, Bradbury AR, Feldman MD, Hexner EO, Bromberg JF, and DeMichele A
  • NPJ breast cancer [NPJ Breast Cancer] 2022 Nov 11; Vol. 8 (1), pp. 122. Date of Electronic Publication: 2022 Nov 11.
Abstract
Circulating IL-6, an activator of JAK/STAT signaling, is associated with poor prognosis and aromatase inhibitor (AI) resistance in hormone-receptor positive (HR+) breast cancer. Here we report the results of a phase 2 single-arm Simon 2-stage trial combining Ruxolitinib, an oral selective inhibitor of JAK1/2, with exemestane, a steroidal AI, in patients with HR+ metastatic breast cancer (MBC) after progression on non-steroidal AI (NSAI). Safety and efficacy were primary objectives, and analysis of inflammatory markers as predictors of response was a key secondary objective. Twenty-five subjects enrolled. The combination of ruxolitinib and exemestane was safe, though anemia requiring transfusion in 5/15 (33%) at the 25 mg dose in stage 1 led to a reduction to 15 mg twice daily in stage 2 (with no additional transfusions). Clinical benefit rate (CBR) in the overall study population was 24% (95% CI 9.4-45.1); 6/25 patients demonstrated stable disease for ≥6 months. Median progression-free survival was 2.8 months (95% CI 2.6-3.9). Exploratory biomarkers revealed high levels of systemic inflammation and 60% harbored a high-risk IL-6 genotype. Pharmacodynamics demonstrated modest on-target inhibition of phosphorylated-STAT3 by ruxolitinib at a tolerable dose. Thus, ruxolitinib combined with exemestane at a tolerable dose was safe but minimally active in AI-resistant tumors of patients with high levels of systemic inflammation. These findings highlight the need for more potent and specific therapies targeting inflammation in MBC.
(© 2022. The Author(s).)

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