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1. Antibody Response to a Fourth Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients: An Update. [2022]

  • Mitchell J, Alejo JL, Chiang TPY, Kim J, Chang A, Abedon AT, Avery RK, Tobian AAR, Massie AB, Levan ML, Warren DS, Garonzik-Wang JM, Segev DL, and Werbel WA
  • Transplantation [Transplantation] 2022 Jul 01; Vol. 106 (7), pp. e338-e340. Date of Electronic Publication: 2022 Apr 15.

2. New Directions in Feminism and Global Race Studies: A Book Conversation. [2022]

  • Florvil, Tiffany N., Glover, Kaiama L., Joseph-Gabriel, Annette K., Marino, Katherine M., Mitchell, Robin, Mogoué, Jacqueline-Bethel, and Pinto, Samantha
  • Signs: Journal of Women in Culture & Society. Summer2022, Vol. 47 Issue 4, p1013-1040. 28p.
Subjects
BLACK feminism, HISTORY of feminism, FEMINISM, BLACK feminists, WORLD history, CONVERSATION, and RACISM
Abstract
This roundtable stems from a Zoom event, "New Directions in Feminism and Global Race Studies (a Book Conversation)" with authors Tiffany N. Florvil, Kaiama L. Glover, Annette K. Joseph-Gabriel, Katherine M. Marino, Robin Mitchell, and Jacqueline-Bethel Tchouta Mougoué, hosted by Samantha Pinto. These scholars discussed their recently published books, which expand how we think about transnational feminism and global Black feminisms in the Americas, the Caribbean, Africa, and Europe. The lightly edited transcript of the conversation explores how putting Black women at the center of histories of global feminisms and race studies transforms these fields and the questions that are usually asked. The authors also discussed navigating research challenges and confronting racism in the sources and in the archives. The conversation underscores the importance of intellectual community, as well as the relevance and urgency of Black feminist scholarship today. [ABSTRACT FROM AUTHOR]

3. Improved humoral immunogenicity with mRNA-1273 versus BNT162b2 as third vaccine dose among solid organ transplant recipients seronegative after two BNT162b2 doses. [2022]

  • Chang A, Chiang TP, Kim JD, Mitchell J, Alejo JL, Jefferis AA, Avery RK, Tobian AAR, Levan ML, Warren DS, Garonzik-Wang JM, Massie AB, Segev DL, and Werbel WA
  • Clinical transplantation [Clin Transplant] 2022 Jun 07, pp. e14738. Date of Electronic Publication: 2022 Jun 07.

4. Incidence and Severity of COVID-19 Among Vaccinated Solid Organ Transplant Recipients During the Omicron Wave. [2022]

  • Alejo JL, Chiang TPY, Bowles Zeiser L, Kim JD, Mitchell J, Avery RK, Tobian AAR, Abedon RR, Levan ML, Warren DS, Garonzik-Wang JM, Massie AB, Segev DL, and Werbel WA
  • Transplantation [Transplantation] 2022 Jun 03. Date of Electronic Publication: 2022 Jun 03.

5. Decade-long disease, secondary malignancy, and brainstem injury outcomes in pediatric and young adult medulloblastoma patients treated with proton radiotherapy. [2022]

  • Baliga S, Gallotto S, Bajaj B, Lewy J, Weyman E, Lawell MP, Yeap BY, Ebb DE, Huang M, Caruso P, Perry A, Jones RM, MacDonald SM, Tarbell NJ, and Yock TI
  • Neuro-oncology [Neuro Oncol] 2022 Jun 01; Vol. 24 (6), pp. 1010-1019.
Subjects
Brain Stem, Child, Cohort Studies, Humans, Protons, Young Adult, Cerebellar Neoplasms drug therapy, and Medulloblastoma drug therapy
Abstract
Background: Survivors of pediatric medulloblastoma experience long-term morbidity associated with the toxic effects of postoperative radiotherapy (RT). Proton RT limits radiation dose to normal tissues thereby reducing side effects of treatment while maintaining high cure rates. However, long-term data on disease outcomes and long-term effects of proton RT remain limited.
Methods: One hundred seventy-eight pediatric medulloblastoma patients treated with proton RT between 2002 and 2016 at the Massachusetts General Hospital comprise the cohort of patients who were treated with surgery, radiation therapy, and chemotherapy. We evaluated event-free survival (EFS), overall survival (OS), and local control using the Kaplan-Meier method. The cumulative incidence of brainstem injury and secondary malignancies was assessed.
Results: Median follow-up was 9.3 years. One hundred fifty-nine patients (89.3%) underwent a gross total resection (GTR). The 10-year OS for the entire cohort, standard-risk (SR), and intermediate/high-risk (IR/HR) patients was 79.3%, 86.9%, and 68.9%, respectively. The 10-year EFS for the entire cohort, SR, and IR/HR cohorts was 73.8%, 79.5%, and 66.2%. The 10-year EFS and OS for patients with GTR/NTR were 75.3% and 81.0% vs 57.7% and 61.0% for subtotal resection (STR). On univariate analysis, IR/HR status was associated with inferior EFS, while both anaplastic histology and IR/HR status were associated with worse OS. The 10-year cumulative incidence of secondary tumors and brainstem injury was 5.6% and 2.1%, respectively.
Conclusions: In this cohort study of pediatric medulloblastoma, proton RT was effective, and disease outcomes were comparable to historically treated photon cohorts. The incidence of secondary malignancies and brainstem injury was low in this cohort with mature follow-up.
(© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

6. Left Atrial Strain Has Superior Prognostic Value to Ventricular Function and Delayed-Enhancement in Dilated Cardiomyopathy. [2022]

  • Raafs AG, Vos JL, Henkens MTHM, Slurink BO, Verdonschot JAJ, Bossers D, Roes K, Gerretsen S, Knackstedt C, Hazebroek MR, Nijveldt R, and Heymans SRB
  • JACC. Cardiovascular imaging [JACC Cardiovasc Imaging] 2022 Jun; Vol. 15 (6), pp. 1015-1026. Date of Electronic Publication: 2022 May 11.
Subjects
Contrast Media, Female, Gadolinium, Heart Atria, Humans, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Predictive Value of Tests, Prognosis, Stroke Volume, Ventricular Function, Left, Cardiomyopathy, Dilated, and Ventricular Dysfunction, Left
Abstract
Background: The left atrium is an early sensor of left ventricular (LV) dysfunction. Still, the prognostic value of left atrial (LA) function (strain) on cardiac magnetic resonance (CMR) in dilated cardiomyopathy (DCM) remains unknown.
Objectives: The goal of this study was to evaluate the prognostic value of CMR-derived LA strain in DCM.
Methods: Patients with DCM from the Maastricht Cardiomyopathy Registry with available CMR imaging were included. The primary endpoint was the combination of sudden or cardiac death, heart failure (HF) hospitalization, or life-threatening arrhythmias. Given the nonlinearity of continuous variables, cubic spline analysis was performed to dichotomize.
Results: A total of 488 patients with DCM were included (median age: 54 [IQR: 46-62] years; 61% male). Seventy patients (14%) reached the primary endpoint (median follow-up: 6 [IQR: 4-9] years). Age, New York Heart Association (NYHA) functional class >II, presence of late gadolinium enhancement (LGE), LV ejection fraction (LVEF), LA volume index (LAVI), LV global longitudinal strain (GLS), and LA reservoir and conduit strain were univariably associated with the outcome (all P < 0.02). LA conduit strain was a stronger predictor of outcome compared with reservoir strain. LA conduit strain, NYHA functional class >II, and LGE remained associated in the multivariable model (LA conduit strain HR: 3.65 [95% CI: 2.01-6.64; P < 0.001]; NYHA functional class >II HR: 1.81 [95% CI: 1.05-3.12; P = 0.033]; and LGE HR: 2.33 [95% CI: 1.42-3.85; P < 0.001]), whereas age, N-terminal pro-B-type natriuretic peptide, LVEF, left atrial ejection fraction, LAVI, and LV GLS were not. Adding LA conduit strain to other independent predictors (NYHA functional class and LGE) significantly improved the calibration, accuracy, and reclassification of the prediction model (P < 0.05).
Conclusions: LA conduit strain on CMR is a strong independent prognostic predictor in DCM, superior to LV GLS, LVEF, and LAVI and incremental to LGE. Including LA conduit strain in DCM patient management should be considered to improve risk stratification.
(Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)

7. Combination Therapy With Casirivimab/Imdevimab and Remdesivir for Protracted SARS-CoV-2 Infection in B-cell-Depleted Patients. [2022]

  • Dioverti, M Veronica, Gaston, David C, Morris, C Paul, Huff, Carol Ann, Jain, Tania, Jones, Richard, Anders, Viki, Lederman, Howard, Saunders, Jacqueline, Mostafa, Heba H, and Avery, Robin K
  • Open Forum Infectious Diseases. Jun2022, Vol. 9 Issue 6, p1-5. 5p.
Subjects
COVID-19, SARS-CoV-2, and REMDESIVIR
Abstract
Profoundly B-cell-depleted patients can have prolonged severe acute respiratory syndrome coronavirus 2 infections with evidence of active viral replication, due to inability to mount an adequate humoral response to clear the virus. We present 3 B-cell-depleted patients with prolonged coronavirus disease 2019 infection who were successfully treated with a combination of casirivimab/imdevimab and remdesivir. [ABSTRACT FROM AUTHOR]

8. Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000–14 (CONCORD-3): analysis of individual data from 258 cancer registries in 61 countries [2022]

  • Ssenyonga, Naomi, Stiller, Charles, Nakata, Kayo, Shalkow, Jaime, Redmond, Sheilagh, Bulliard, Jean-Luc, Girardi, Fabio, Fowler, Christine, Marcos-Gragera, Raphael, Bonaventure, Audrey, Saint-Jacques, Nathalie, Minicozzi, Pamela, De, Prithwish, Rodríguez-Barranco, Miguel, Larønningen, Siri, Di Carlo, Veronica, Mägi, Margit, Valkov, Mikhail, Seppä, Karri, Wyn Huws, Dyfed, Coleman, Michel P, Allemani, Claudia, Bouzbid, Sabiha, Hamdi-Chérif, Mokhtar, Kara, Lamia, Meguenni, Kaouel, Regagba, Derbali, Bayo, Sine, Cheick Bougadari, Traore, Manraj, Shyam Shunker, Bendahhou, Karima, Ladipo, Akinade, Ogunbiyi, Olufemi, Somdyala, Nontuthuzelo, Chaplin, María Agustina, Moreno, Florencia, Calabrano, Gladis, Espinola, Silvia, Carballo Quintero, Beatriz, Fita, Rosalba, Laspada, Walter, Ibañez, Susana, Lima, Carlos, Mafra Da Costa, Allini, De Souza, Paulo César, Chaves, Juliana, Laporte, Cyntia, Curado, Maria Paula, de Oliveira, Jose Carlos, Veneziano, Claudia, Veneziano, Donaldo, Almeida, Ana Beatriz, Latorre, Maria, Azevedo e Silva, Gulnar, Rebelo, Marise, Santos, Marceli, Galaz, Juan, Aparicio Aravena, Mackarena, Sanhueza Monsalve, Jocelyn, Herrmann, Denise, Vargas, Solange, Herrera, Victor, Uribe, Claudia, Bravo, Luis Eduardo, Garcia, Luz Stella, Arias-Ortiz, Nelson, Morantes, Daniela, Jurado, Daniel, Yépez Chamorro, María, Delgado, Sandra, Ramirez, Melissa, Galán Alvarez, Yaima, Torres, Priscila, Martínez-Reyes, Fray, Jaramillo, Leyda, Quinto, Rina, Castillo, Jhoanna, Mendoza, Mariela, Cueva, Patricia, Yépez, José, Bhakkan, Bernard, Deloumeaux, Jacqueline, Joachim, Clarisse, Macni, Jonathan, Carrillo, Rodolfo, Shalkow Klincovstein, Jaime, Rivera Gomez, Rebeca, Perez, Patricia, Poquioma, Ebert, Tortolero-Luna, Guillermo, Zavala, Diego, Alonso, Rafael, Barrios, Enrique, Eckstrand, Angela, Nikiforuk, Cindy, Woods, Ryan, Noonan, Gail, Turner, Donna, Kumar, Eshwar, Zhang, Bin, Dowden, Jeff, Doyle, Gregory, Saint-Jacques, Nathalie, Walsh, Gordon, Anam, Aniq, De, Prithwish, McClure, Carol, Vriends, Kim, Bertrand, Christine, Ramanakumar, Agnihotram, Kozie, Serena, Stuart-Panko, Heather, Freeman, Tara, George, Justin, Avila, Rosa, O'Brien, David, Holt, Abby, Almon, Lyn, Ward, Kevin, Kwong, Sandy, Morris, Cyllene, Rycroft, Randi, Mueller, Lloyd, Phillips, Cathryn, Brown, Heather, Cromartie, Betsy, Ruterbusch, Julie, Schwartz, Ann, Levin, Gary, Wohler, Brad, Bayakly, Rana, Gomez, Scarlett, McKinley, Meg, Cress, Rosemary, Davis, Joni, Hernandez, Brenda, Johnson, Christopher, Morawski, Bozena, Ruppert, Laura, Bentler, Suzanne, Charlton, Mary, Huang, Bin, Tucker, Thomas, Deapen, Dennis, Liu, Lihua, Hsieh, Mei-Chin, Wu, Xiao-Cheng, Schwenn, Molly, Stern, Kimberly, Gershman, Susan, Knowlton, Richard, Alverson, Georgetta, Weaver, Tamara, Desai, Jay, Rogers, Deirdre, Jackson-Thompson, Jeanette, Lemons, Debbi, Zimmerman, Heather, Hood, Michelle, Roberts-Johnson, Jenifer, Hammond, Whitney, Rees, Judith, Pawlish, Karen, Stroup, Antoinette, Key, Charles, Wiggins, Charles, Kahn, Amy, Schymura, Maria, Radhakrishnan, Soundarya, Rao, Chandrika, Giljahn, Lynn, Slocumb, Roberta, Dabbs, Christy, Espinoza, Raffaella, Aird, Karen, Beran, Todd, Rubertone, Jim, Slack, Stephen, Oh, Junhie, Janes, Tiffany, Schwartz, Stephen, Chiodini, Stephanie, Hurley, Deborah, Whiteside, Martin, Rai, Saroj, Williams, Melanie, Herget, Kim, Sweeney, Carol, Johnson, Alison, Keitheri Cheteri, Mahesh, Migliore Santiago, Patti, Blankenship, Steven, Farley, Shawn, Borchers, Robert, Malicki, Robin, Espinoza, Julia, Grandpre, Joseph, Edwards, Brenda, Mariotto, Angela, Weir, Hannah, Wilson, Reda, Wang, Ning, Yang, Lei, Chen, Jian-Shun, He, Yu-Tong, Song, Guo-Hui, Gu, Xiao-Ping, Mei, Dan, Ge, Heng-Ming, Wu, Tong-Hao, Li, Yan-Yan, Zhao, De-Li, Jin, Feng, Zhang, Jian-Hua, Zhu, Feng-Dong, Junhua, Qian, Yang, Yan Lei, Jiang, Chun-Xiao, Biao, Wang, Wang, Jian, Li, Qi-Long, Yi, He, Zhou, Xin, Dong, JianMei, Li, WeiWei, Fu, Fang-Xian, Chen, Jian-Guo, Zhu, Jian, Li, Yan-Hua, Lu, Yu-Qiang, Fan, Min, Huang, Su-Qin, Guo, Guo-Ping, Zhaolai, Hua, Wei, Kuangrong, Chen, Wan-Qing, Wei, Wenqiang, Zeng, Hongmei, Demetriou, Anna, Mang, Wai Kong, Ngan, Kai Cheong, Kataki, Amal, Krishnatreya, Manigreeva, Jayalekshmi, Padmavathi Amma, Sebastian, Paul, George, Preethi, Mathew, Aleyamma, Nandakumar, Ambakumar, Malekzadeh, Reza, Roshandel, Gholamreza, Keinan-Boker, Lital, Silverman, Barbara, Ito, Hidemi, Koyanagi, Yuriko, Sato, Masako, Tobori, Fumio, Nakata, Ichiro, Teramoto, Norihiro, Hattori, Masakazu, Kaizaki, Yasuharu, Moki, Fumitaka, Sugiyama, Hiromi, Utada, Mai, Nishimura, Makiko, Yoshida, Keiichi, Kurosawa, Katsuki, Nemoto, Yuji, Narimatsu, Hiroto, Sakaguchi, Masahiko, Kanemura, Seiki, Naito, Michiko, Narisawa, Rintaro, Miyashiro, Isao, Nakata, Kayo, Mori, Daisuke, Yoshitake, Mayuko, Oki, Izumi, Fukushima, Norimasa, Shibata, Akiko, Iwasa, Keiichiro, Ono, Chie, Matsuda, Tomohiro, Nimri, Omar, Jung, Kyu-Won, Won, Young-Joo, Alawadhi, Eiman, Elbasmi, Amani, Ab Manan, Azizah, Adam, Farzaana, Nansalmaa, Erdenekhuu, Tudev, Undarmaa, Ochir, Chimedsuren, Al Khater, Al Hareth, El Mistiri, Mufid, Lim, Gek Hsiang, Teo, Yik Ying, Chiang, Chun-Ju, Lee, Wen-Chung, Buasom, Rangsiya, Sangrajrang, Suleeporn, Suwanrungruang, Krittika, Vatanasapt, Patravoot, Daoprasert, Karnchana, Pongnikorn, Donsuk, Leklob, Atit, Sangkitipaiboon, Somphob, Geater, Sarayut, Sriplung, Hutcha, Ceylan, Okan, Kög, Iskender, Dirican, Oya, Köse, Tülay, Gurbuz, Tulın, Karašahin, Füsun Emine, Turhan, Duygu, Aktaş, Umut, Halat, Yakup, Eser, Sultan, Yakut, Cankut, Altinisik, Merve, Cavusoglu, Yasar, Türkköylü, Ayşe, Üçüncü, Nuršen, Hackl, Monika, Zborovskaya, Anna, Aleinikova, Olga, Henau, Kris, Van Eycken, Liesbet, Atanasov, Trayan, Valerianova, Zdravka, Šekerija, Mario, Dušek, Ladislav, Zvolský, Miroslav, Steinrud Mørch, Lina, Storm, Hans, Wessel Skovlund, Charlotte, Innos, Kaire, Mägi, Margit, Malila, Nea, Seppä, Karri, Jégu, Jérémie, Velten, Michel, Cornet, Edouard, Troussard, Xavier, Bouvier, Anne-Marie, Guizard, Anne-Valérie, Bouvier, Véronique, Launoy, Guy, Dabakuyo Yonli, Sandrine, Poillot, Marie-Laure, Maynadié, Marc, Mounier, Morgane, Vaconnet, Lina, Woronoff, Anne-Sophie, Daoulas, Mélanie, Robaszkiewicz, Michel, Clavel, Jacqueline, Poulalhon, Claire, Desandes, Emmanuel, Lacour, Brigitte, Baldi, Isabelle, Pouchieu, Camille, Amadeo, Brice, Coureau, Gaëlle, Monnereau, Alain, Audoin, Magali, D'Almeida, Tania, Boyer, Séverine, Hammas, Karima, Trétarre, Brigitte, Colonna, Marc, Delafosse, Patricia, Plouvier, Sandrine, Cowppli-Bony, Anne, Molinié, Florence, Bara, Simona, Ganry, Olivier, Lapôtre-Ledoux, Bénédicte, Daubisse-Marliac, Laetitia, Bossard, Nadine, Estève, Jacques, Uhry, Zoé, Stabenow, Roland, Wilsdorf-Köhler, Heide, Eberle, Andrea, Luttmann, Sabine, Löhden, Imma, Nennecke, Alice, Kieschke, Joachim, Sirri, Eunice, Justenhoven, Christina, Zeissig, Sylke, Holleczek, Bernd, Eisemann, Nora, Katalinic, Alexander, Asquez, Rachelle, Kumar, Vijay, Petridou, Eleni, Ólafsdóttir, Elínborg, Tryggvadóttir, Laufey, Murray, Deirdre, Walsh, Paul, Sundseth, Hildrun, Mazzoleni, Guido, Vittadello, Fabio, Coviello, Enzo, Cuccaro, Francesco, Galasso, Rocco, Sampietro, Giuseppe, Magoni, Michele, Ardizzone, Antonino, D'Argenzio, Angelo, Di Prima, Alessia Anna, Ippolito, Antonella, Lavecchia, Anna Maria, Sutera Sardo, Antonella, Gola, Gemma, Ballotari, Paola, Giacomazzi, Erica, Ferretti, Stefano, Dal Maso, Luigino, Serraino, Diego, Celesia, Maria Vittoria, Filiberti, Rosa Angela, Pannozzo, Fabio, Melcarne, Anna, Quarta, Fabrizio, Andreano, Anita, Russo, Antonio Giampiero, Carrozzi, Giuliano, Cirilli, Claudia, Cavalieri d'Oro, Luca, Rognoni, Magda, Fusco, Mario, Vitale, Maria Francesca, Usala, Mario, Cusimano, Rosanna, Mazzucco, Walter, Michiara, Maria, Sgargi, Paolo, Boschetti, Lorenza, Chiaranda, Giorgio, Seghini, Pietro, Maule, Milena, Merletti, Franco, Spata, Eugenia, Tumino, Rosario, Mancuso, Pamela, Vicentini, Massimo, Cassetti, Tiziana, Sassatelli, Romano, Falcini, Fabio, Giorgetti, Stefania, Caiazzo, Anna Luisa, Cavallo, Rossella, Piras, Daniela, Bella, Francesca, Madeddu, Anselmo, Fanetti, Anna Clara, Maspero, Sergio, Carone, Simona, Mincuzzi, Antonia, Candela, Giuseppa, Scuderi, Tiziana, Gentilini, Maria Adalgisa, Rizzello, Roberto, Rosso, Stefano, Zanetti, Roberto, Caldarella, Adele, Intrieri, Teresa, Bianconi, Fortunato, Stracci, Fabrizio, Contiero, Paolo, Tagliabue, Giovanna, Rugge, Massimo, Zorzi, Manuel, Beggiato, Simonetta, Brustolin, Angelita, De Angelis, Roberta, Gatta, Gemma, Maurina, Anita, Oniščuka, Marija, Mousavi, Mohsen, Lipunova, Nadezda, Vincerzevskienė, Ieva, Agius, Dominic, Calleja, Neville, Siesling, Sabine, Visser, Otto, Johannesen, Tom, Larønningen, Siri, Trojanowski, Maciej, Mierzwa, Tomasz, Rachtan, Jadwiga, Kępska, Kamila, Kościańska, Beata, Wójcik-Tomaszewska, Joanna, Motnyk, Marcin, Gos, Anna, Bielska-Lasota, Magdalena, Didkowska, Joanna, Wojciechowska, Urszula, Forjaz de Lacerda, Gonçalo, Rego, Raul, Carrito, Branca, Pais, Ana, Bento, Maria José, Rodrigues, Jessica, Lourenço, Antonio, Mayer-da-Silva, Alexandra, Blaga, Luminita, Coza, Daniela, Valkov, Mikhail, Gusenkova, Lubov, Lazarevich, Olga, Prudnikova, Olga, Vjushkov, Dmitri Mikhailovich, Egorova, Alla, Orlov, Andrey, Pikalova, Lidiya, Zhuikova, Lilia, Adamcik, Juraj, Safaei Diba, Chakameh, Zadnik, Vesna, Zagar, Tina, De-La-Cruz, Marta, Lopez-de-Munain, Arantza, Aleman, Araceli, Rojas, Dolores, Chillarón, Rosario Jiménez, Navarro, Ana Isabel Marcos, Marcos-Gragera, Rafael, Puigdemont, Montse, Rodríguez-Barranco, Miguel, Sánchez Perez, María-José, Franch Sureda, Paula, Ramos Montserrat, Maria, Chirlaque López, Maria Dolores, Sánchez Gil, Antonia, Ardanaz, Eva, Guevara, Marcela, Cañete-Nieto, Adela, Peris-Bonet, Rafael, Carulla, Marià, Galceran, Jaume, Almela, Fernando, Sabater, Consol, Khan, Staffan, Pettersson, David, Dickman, Paul, Staehelin, Katharina, Struchen, Benjamin, Herrmann, Christian, Mousavi, Seyed Mohsen, Egger Hayoz, Céline, Bouchardy, Christine, Schaffar, Robin, Went, Philip, Bulliard, Jean-Luc, Maspoli-Conconi, Manuela, Kuehni, Claudia, Redmond, Shelagh, Bordoni, Andrea, Ortelli, Laura, Chiolero, Arnaud, Konzelmann, Isabelle, Rohrmann, Sabine, Wanner, Miriam, Broggio, John, Rashbass, Jem, Stiller, Charles, Fitzpatrick, Deirdre, Gavin, Anna, Morrison, David, Thomson, Catherine, Greene, Giles, Huws, Dyfed, Allemani, Claudia, Coleman, Michel, Di Carlo, Veronica, Girardi, Fabio, Matz, Melissa, Minicozzi, Pamela, Sanz, Natalia, Ssenyonga, Naomi, Stephens, Richard, Chalker, Elizabeth, Smith, Mirka, Gugusheff, Jessica, You, Hui, Qin Li, Shu, Dugdale, Sarah, Moore, Julie, Philpot, Shoni, Pfeiffer, Rhonda, Thomas, Helen, Silva Ragaini, Bruna, Venn, Alison, Evans, Sue, Te Marvelde, Luc, Savietto, Vedrana, Trevithick, Richard, Currow, David, Fowler, Christine, and Lewis, Chris
  • The Lancet Child & Adolescent Health; June 2022, Vol. 6 Issue: 6 p409-431, 23p
Abstract
Leukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed data for children (aged 0–14 years) and adults (aged 15–99 years) diagnosed with a haematological malignancy during 2000–14 in 61 countries. Here, we aimed to examine worldwide trends in survival from leukaemia, by age and morphology, in young patients (aged 0–24 years).

9. A novel air microfluidics-enabled soft robotic sleeve: Toward realizing innovative lymphedema treatment. [2022]

  • Gao RZ, Mai VNT, Levinski N, Kormylo JM, Murdock RW, Dickerson CR, and Ren CL
  • Biomicrofluidics [Biomicrofluidics] 2022 May 03; Vol. 16 (3), pp. 034101. Date of Electronic Publication: 2022 May 03 (Print Publication: 2022).
Abstract
A proof of concept of a novel air microfluidics-enabled soft robotic sleeve to enable lymphedema treatment is presented. Compression sleeves represent the current, suboptimal standard of care, and stationary pumps assist with lymph drainage; however, effective systems that are truly wearable while performing daily activities are very scarce. This problematic trade-off between performance and wearability requires a new solution, which is addressed by an innovative microfluidic device. Its novelty lies in the use of light, small, and inexpensive air microfluidic chips (35 × 20 × 5 mm 3 in size) that bring three major advantages compared to their traditional counterparts. First, each chip is designed with 16 fluidic channels with a cross-sectional area varying from 0.04 to 1 mm 2 , providing sequential inflation and uniform deflation capability to eight air bladders, thereby producing intentional gradient compression to the arm to facilitate lymph fluid circulation. The design is derived from the fundamentals of microfluidics, in particular, hydraulic resistance and paths of least resistance. Second, the air microfluidic chip enables miniaturization of at least eight bulky energy-consuming valves to two miniature solenoid valves for control increasing wearability. Third, the air microfluidic chip has no moving parts, which reduces the noise and energy needed. The cost, simplicity, and scale-up potential of developing methods for making the system are also detailed. The sequential inflation, uniform deflation, and pressure gradient are demonstrated, and the resulted compression and internal air bladder pressure were evaluated. This air microfluidics-enabled sleeve presents tremendous potential toward future improvements in self-care lymphedema management.
(© 2022 Author(s).)

10. Improved Antibody Response After a Fifth Dose of a SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients: A Case Series. [2022]

  • Abedon AT, Teles MS, Alejo JL, Kim JD, Mitchell J, Chiang TPY, Avery RK, Tobian AAR, Levan ML, Warren DS, Massie AB, Garonzik-Wang JM, Segev DL, and Werbel WA
  • Transplantation [Transplantation] 2022 May 01; Vol. 106 (5), pp. e262-e263. Date of Electronic Publication: 2022 Feb 15.
Subjects
Antibodies, Viral, Antibody Formation, COVID-19 Vaccines, Humans, SARS-CoV-2, Transplant Recipients, COVID-19 prevention control, and Organ Transplantation adverse effects

11. Humoral and Cellular Immune Response to a Third Dose of SARS-CoV-2 Vaccine in Kidney Transplant Recipients Taking Belatacept. [2022]

  • Mitchell J, Kim J, Alejo JL, Chiang TP, Karaba AH, Blankson JN, Aytenfisu TY, Chang A, Abedon AT, Avery RK, Tobian AA, Massie AB, Levan ML, Warren DS, Garonzik-Wang JM, Segev DL, and Werbel WA
  • Transplantation [Transplantation] 2022 May 01; Vol. 106 (5), pp. e264-e265. Date of Electronic Publication: 2022 Mar 14.
Subjects
Abatacept therapeutic use, Antibodies, Viral, COVID-19 Vaccines, Humans, Immunity, Cellular, SARS-CoV-2, Transplant Recipients, COVID-19 prevention control, and Kidney Transplantation adverse effects

12. Effect of Mycophenolate Mofetil Dosing on Antibody Response to SARS-CoV-2 Vaccination in Heart and Lung Transplant Recipients. [2022]

  • Mitchell J, Chiang TP, Alejo JL, Chang A, Abedon AT, Avery RK, Tobian AAR, Massie AB, Levan ML, Warren DS, Garonzik-Wang JM, Segev DL, and Werbel WA
  • Transplantation [Transplantation] 2022 May 01; Vol. 106 (5), pp. e269-e270. Date of Electronic Publication: 2022 Mar 03.
Subjects
Antibodies, Viral, Antibody Formation, COVID-19 Vaccines, Humans, Immunosuppressive Agents adverse effects, Lung, Mycophenolic Acid, SARS-CoV-2, Vaccination, COVID-19 prevention control, and Transplant Recipients

13. Six-month Antibody Kinetics and Durability After 3 Doses of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients: A Case Series. [2022]

  • Abedon AT, Alejo JL, Kim JD, Thomas L, Mitchell J, Chiang TPY, Avery RK, Tobian AAR, Levan ML, Warren DS, Massie AB, Garonzik-Wang JM, Segev DL, and Werbel WA
  • Transplantation [Transplantation] 2022 May 01; Vol. 106 (5), pp. e281-e283. Date of Electronic Publication: 2022 Jan 19.
Subjects
Antibodies, Viral, COVID-19 Vaccines, Humans, Kinetics, SARS-CoV-2, Transplant Recipients, COVID-19 prevention control, and Organ Transplantation adverse effects

14. Dental management of a pediatric patient with Kohlschutter-Tonz syndrome: A case report. [2022]

  • Kulkarni R, Caster JM, Robin A, Hajishengallis E, Stoopler ET, and Tanaka TI
  • Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [Spec Care Dentist] 2022 May; Vol. 42 (3), pp. 308-311. Date of Electronic Publication: 2021 Nov 12.
Subjects
Child, Dementia, Dental Care, Humans, Amelogenesis Imperfecta therapy, Epilepsy, and Intellectual Disability
Abstract
Introduction: Kohlschutter-Tonz syndrome (KTS) is a rare, genetic condition, which typically manifests as a triad of symptoms: 1) amelogenesis imperfecta, 2) infantile onset epilepsy, and 3) intellectual disability. The condition poses dental treatment challenges given the manifestation of amelogenesis imperfecta. Additional considerations are needed to medically manage these patients who present with epilepsy and intellectual disability.
Case Report: Our patient presented with multiple restorative needs, was treated under general anesthesia, and maintained good oral outcomes with close follow-up.
Discussion: To the best of our knowledge, this is the first case report which documents comprehensive dental management of a pediatric patient with KTS.
(© 2021 Special Care Dentistry Association and Wiley Periodicals LLC.)

15. Implementing Gentle Persuasive Approaches dementia education for staff on in-patient medicine units: A program evaluation. [2022]

  • Crandall J, Coatsworth-Puspoky R, Schlegel K, Beker L, McLelland VC, and Martin LS
  • Dementia (London, England) [Dementia (London)] 2022 May; Vol. 21 (4), pp. 1173-1199. Date of Electronic Publication: 2022 Jan 26.
Subjects
Aged, Canada, Hospitals, Humans, Program Evaluation, Dementia therapy, and Education, Distance
Abstract
Older adults with dementia, when hospitalised, frequently experience responsive behaviours. Staff struggle to manage responsive behaviours without specific education. We aimed to enhance staff knowledge and confidence with care for older adults with dementia and responsive behaviours on medicine units at a Canadian hospital. An online dementia education program was disseminated to staff as part of a broader quality improvement project. Gentle Persuasive Approaches (GPA) encourages staff to reframe responsive behaviours as self-protective expressions of unmet needs and learn to assess their meaning. Participants completed online quantitative and qualitative measures of self-efficacy, competence and knowledge in dementia care at three times: immediate pre-, immediate post- and six to eight weeks post-GPA eLearning. Immediately post-GPA, participants showed significant increases relative to baseline in dementia care self-efficacy, competence and knowledge. Self-efficacy scores increased further eight weeks post-GPA. Before GPA, few participants described dementia-specific strategies for de-escalating a patient's agitation. Eight weeks post-GPA, participants described application of tailored, person-centred, non-pharmacological interventions and successful application of GPA strategies. GPA eLearning strengthened staff preparedness to interact with older adults experiencing responsive behaviours, thus enhancing their care.

16. Evaluation of Left Cardiac Chamber Function with Cardiac Magnetic Resonance and Association with Outcome in Patients with Systemic Sclerosis. [2022]

  • Butcher SC, Vos JL, Fortuni F, Galloo X, Liem SIE, Bax JJ, Delgado V, Vonk MC, van Leuven SI, Snoeren M, El Messaoudi S, de Vries-Bouwstra JK, Nijveldt R, and Ajmone Marsan N
  • Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2022 Apr 28. Date of Electronic Publication: 2022 Apr 28.
Abstract
Objective: This study aimed to determine whether lower values of feature-tracking cardiovascular magnetic resonance (CMR)-derived left atrial (LA) reservoir strain (LARS) and impaired left ventricular (LV) global longitudinal strain (GLS) were associated with the presence of symptoms and long-term prognosis in patients with systemic sclerosis (SSc).
Methods: A total of 100 patients (54[IQR 46-64] years, 42% male) with SSc who underwent CMR imaging at two tertiary referral centres were included. All patients underwent analysis of LARS and LV GLS using feature-tracking on CMR and were followed-up for the occurrence of all-cause mortality.
Results: The median LV GLS was -21.8% and the median LARS was 36%. On multivariable logistic regression, LARS (OR 0.964 per %, 95%CI 0.929-0.998, p = 0.049) was independently associated with New York Heart Association (NYHA) class II-IV heart failure symptoms. Over a median follow-up of 37 (21-62) months, a total of 24 (24%) patients died. Univariable Cox regression analysis demonstrated that LARS (HR 0.94 per %, 95%CI 0.91-0.97, P < 0.0001) and LV GLS (HR 1.10 per %, 95%CI 1.03- 1.17, P = 0.005) were associated with all-cause mortality, while LV ejection fraction was not. Likelihood ratio tests demonstrated that LARS provided incremental value over prognostically important clinical and imaging parameters, including late gadolinium enhancement.
Conclusion: In patients with SSc, LARS was independently associated with the presence of NYHA class II-IV heart failure symptoms. Although both LARS and LV GLS were associated with all-cause mortality, only LARS provided incremental value over all evaluated variables known to be prognostically important in patients with SSc.
(© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

17. Disseminated Intravascular Coagulation in Varying Age Groups Based on Clinical Conditions. [2022]

  • Geyer-Roberts E, Akhand T, Blanco A, Jose R, Chowdhury N, Ea M, Gutierrez E, Balbuena J, Anagnostis S, Henderson C, Fazio A, Burpee A, and Jacobs RJ
  • Cureus [Cureus] 2022 Apr 21; Vol. 14 (4), pp. e24362. Date of Electronic Publication: 2022 Apr 21 (Print Publication: 2022).
Abstract
Disseminated intravascular coagulation (DIC) is a serious syndrome characterized by the systemic activation of blood coagulation resulting in the thrombosis of vessels leading to organ dysfunction and severe bleeding. When physicians try to treat DIC, it is imperative to diagnose and treat the underlying conditions. Anyone can be affected by DIC, but vulnerable groups such as pediatric populations, pregnant women and the elderly may be at higher risk. In this review, the current literature on DIC in pregnancy, the pediatric population, and the elderly is reported. This review also highlights the similarities and differences in the etiology, clinical presentation, diagnosis, and management of DIC in the aforementioned groups (i.e., pediatrics, pregnant women, and the elderly). Findings from this study may help increase awareness about various presentations of DIC in these groups to facilitate rapid recognition of symptoms leading to correct diagnoses.
(Copyright © 2022, Geyer-Roberts et al.)

18. Infectious diseases, comorbidities and outcomes in hospitalized people who inject drugs (PWID) infections in persons who inject drugs. [2022]

  • Lim J, Pavalagantharajah S, Verschoor CP, Lentz E, Loeb M, Levine M, Smieja M, Mbuagbaw L, Kalina D, Tarride JE, O'Shea T, Cvetkovic A, van Gaalen S, Findlater AR, Lennox R, Bassim C, Lokker C, and Alvarez E
  • PloS one [PLoS One] 2022 Apr 20; Vol. 17 (4), pp. e0266663. Date of Electronic Publication: 2022 Apr 20 (Print Publication: 2022).
Subjects
Hospitalization, Humans, Communicable Diseases complications, Communicable Diseases epidemiology, Drug Users, Endocarditis complications, Substance Abuse, Intravenous complications, and Substance Abuse, Intravenous epidemiology
Abstract
Injection drug use poses a public health challenge. Clinical experience indicates that people who inject drugs (PWID) are hospitalized frequently for infectious diseases, but little is known about outcomes when admitted. Charts were identified from local hospitals between 2013-2018 using consultation lists and hospital record searches. Included individuals injected drugs in the past six months and presented with infection. Charts were accessed using the hospital information system, undergoing primary and secondary reviews using Research Electronic Data Capture (REDCap). The Wilcoxon rank-sum test was used for comparisons between outcome categories. Categorical data were summarized as count and frequency, and compared using Fisher's exact test. Of 240 individuals, 33% were admitted to the intensive care unit, 36% underwent surgery, 12% left against medical advice (AMA), and 9% died. Infectious diagnoses included bacteremia (31%), abscess (29%), endocarditis (29%), cellulitis (20%), sepsis (10%), osteomyelitis (9%), septic arthritis (8%), pneumonia (7%), discitis (2%), meningitis/encephalitis (2%), or other (7%). Sixty-six percent had stable housing and 60% had a family physician. Fifty-four percent of patient-initiated discharges were seen in the emergency department within 30 days and 29% were readmitted. PWID are at risk for infections. Understanding their healthcare trajectory is essential to improve their care.

19. How to evaluate cardiomyopathies by cardiovascular magnetic resonance parametric mapping and late gadolinium enhancement. [2022]

  • Menghoum N, Vos JL, Pouleur AC, Nijveldt R, and Gerber BL
  • European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2022 Apr 18; Vol. 23 (5), pp. 587-589.
Subjects
Contrast Media, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Myocardium pathology, Predictive Value of Tests, Cardiomyopathies diagnostic imaging, Cardiomyopathies pathology, and Gadolinium

20. Heterologous Ad.26.COV2.S versus homologous BNT162b2/mRNA-1273 as a third dose in solid organ transplant recipients seronegative after two-dose mRNA vaccination. [2022]

  • Chiang TP, Alejo JL, Mitchell J, Kim JD, Abedon AT, Karaba AH, Thomas L, Levan ML, Garonzik-Wang JM, Avery RK, Pekosz A, Clarke WA, Warren DS, Tobian AAR, Massie AB, Segev DL, and Werbel WA
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2022 Apr 16. Date of Electronic Publication: 2022 Apr 16.
Abstract
Heterologous vaccination ("mixing platforms") for the third (D3) dose of SARS-CoV-2 vaccine is a potential strategy to improve antibody responses in solid organ transplant recipients (SOTRs), but data are mixed regarding potential differential immunogenicity. We assessed for differences in immunogenicity and tolerability of homologous (BNT162b2 or mRNA-1273; D3-mRNA) versus heterologous (Ad.26.COV2.S; D3-JJ) D3 among 377 SARS-CoV-2-infection naïve SOTRs who remained seronegative after two mRNA vaccines. We measured anti-spike titers and used weighted Poisson regression to evaluate seroconversion and development of high-titers, comparing D3-JJ to D3-mRNA, at 1-, 3-, and 6 month post-D3. 1-month post-D3, seroconversion (63% vs. 52%, p = .3) and development of high-titers (29% vs. 25%, p = .7) were comparable between D3-JJ and D3-mRNA recipients. 3 month post-D3, D3-JJ recipients were 1.4-fold more likely to seroconvert (80% vs. 57%, weighted incidence-rate-ratio: wIRR =  1.10 1.40 1.77 , p = .006) but not more likely to develop high-titers (27% vs. 22%, wIRR =  0.44 0.92 1.93 , p = .8). 6 month post-D3, D3-JJ recipients were 1.41-fold more likely to seroconvert (88% vs. 59%, wIRR =  1.04 1.41 1.93 , p = .029) and 2.63-fold more likely to develop high-titers (59% vs. 21%, wIRR =  1.38 2.63 5.00 , p = .003). There was no differential signal in alloimmune events or reactogenicity between platforms. SOTRs without antibody response after two mRNA vaccines may derive benefit from heterologous Ad.26.COV2.S D3.
(© 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.)

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