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United States. National Institutes of Health -- Analysis, Lipids -- Analysis, Genetic research -- Analysis -- Genetic aspects, Biological sciences, University of Oxford, University of Pennsylvania. Perelman School of Medicine, University of North Carolina at Chapel Hill, Harvard University. Harvard Medical School, University of Michigan, Boston University. School of Public Health, Rush University. Medical Center, and Stanford University. School of Medicine

Million Veterans Program Keywords lipid biology; fine-mapping; functional genomics; post-GWAS; regulatory mechanism; complex traits; variant prioritization Summary A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow the search for functional genes. Polygenic enrichment analysis across 697 annotations from a host of tissues and cell types confirms the central role of the liver in lipid levels and highlights the selective enrichment of adipose-specific chromatin marks in high-density lipoprotein cholesterol and triglycerides. Overlapping transcription factor (TF) binding sites with lipid-associated loci identifies TFs relevant in lipid biology. In addition, we present an integrative framework to prioritize causal variants at GWAS loci, producing a comprehensive list of candidate causal genes and variants with multiple layers of functional evidence. We highlight two of the prioritized genes, CREBRF and RRBP1, which show convergent evidence across functional datasets supporting their roles in lipid biology. Author Affiliation: (1) Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA (2) Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA (3) Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, USA (4) William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK (5) Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA 02118, USA (6) VA Palo Alto Health Care Systems, Palo Alto, CA, USA (7) Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA (8) Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA (9) Endocrinology, Boston Childrens Hospital, Boston, MA 02115, USA (10) Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA (11) Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany (12) McDonnell Genome Institute and Department of Medicine, Washington University, St. Louis, MO 63108, USA (13) Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA (14) Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA (15) Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ London, UK (16) Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA (17) Atlanta VA Health Care System, Decatur, GA, USA (18) Malcolm Randall VA Medical Center, Gainesville, FL, USA (19) Division of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL, USA (20) deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik 102, Iceland (21) School of Engineering and Natural Sciences, University of Iceland, Sæmundargötu 2, Reykjavik 102, Iceland (22) Department of Clinical Biochemistry, Landspitali - National University Hospital of Iceland, Hringbraut, Reykjavik 101, Iceland (23) Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungbuk, South Korea (24) Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (25) Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (26) Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan (27) Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, The University of Tokyo, Tokyo, Japan (28) Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (29) Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (30) Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA (31) Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA (32) K.G. 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Graham (3,420), Stavroula Kanoni (4,420), Yuxuan Wang (5,420), Ida Surakka (3), Brandon Wenz (1), Shoa L. Clarke (6,7), Alessandra Chesi (8), Andrew Wells (1), Konain Fatima Bhatti (4), Sailaja Vedantam (9,10), Thomas W. Winkler (11), Adam E. Locke (12), Eirini Marouli (4), Greg J.M. Zajac (13), Kuan-Han H. Wu (14), Ioanna Ntalla (15), Qin Hui (16,17), Derek Klarin (10,18,19), Austin T. Hilliard (6), Zeyuan Wang (16,17), Chao Xue (3), Gudmar Thorleifsson (20), Anna Helgadottir (20), Daniel F. Gudbjartsson (20,21), Hilma Holm (20), Isleifur Olafsson (22), Mi Yeong Hwang (23), Sohee Han (23), Masato Akiyama (24,25), Saori Sakaue (26,27,28), Chikashi Terao (29), Masahiro Kanai (10,24,30), Wei Zhou (10,14,31), Ben M. Brumpton (32,33,34), Humaira Rasheed (32,33,35), Aki S. Havulinna (36,37), Yogasudha Veturi (38), Jennifer Allen Pacheco (39), Elisabeth A. Rosenthal (40), Todd Lingren (41), QiPing Feng (42), Iftikhar J. Kullo (43), Akira Narita (44), Jun Takayama (44), Hilary C. 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Chandak (152,153,307), Josep M. Mercader (308,309,310), Clicerio Gonzalez Villalpando (312), Lorena Orozco (313), Myriam Fornage (148,314), E. Shyong Tai (78,315), Rob M. van Dam (78,315), Terho Lehtimäki (216,217), Nish Chaturvedi (316), Mitsuhiro Yokota (317), Jianjun Liu (144), Dermot F. Reilly (318), Amy Jayne McKnight (139), Frank Kee (139), Karl-Heinz Jöckel (138), Mark I. McCarthy (60,208), Colin N.A. Palmer (319), Veronique Vitart (137), Caroline Hayward (137), Eleanor Simonsick (320), Cornelia M. van Duijn (132,133), Zi-Bing Jin (173,321), Fan Lu (321), Haretsugu Hishigaki (129), Xu Lin (128), Winfried März (126,322,323), Vilmundur Gudnason (125,324), Jean-Claude Tardif (124), Guillaume Lettre (124), Leen M. t Hart (122,123,325), Petra J.M. Elders (326), Daniel J. Rader (327,407), Scott M. Damrauer (121,328), Meena Kumari (329), Mika Kivimaki (120), Pim van der Harst (118), Tim D. Spector (116), Ruth J.F. Loos (86,115,330), Michael A. Province (108), Esteban J. Parra (113), Miguel Cruz (331), Bruce M. Psaty (112,226,332), Ivan Brandslund (111,333), Peter P. Pramstaller (110), Charles N. Rotimi (334), Kaare Christensen (335), Samuli Ripatti (36,336,337), Elisabeth Widén (36), Hakon Hakonarson (338,339), Struan F.A. Grant (327,339,340), Lambertus Kiemeney (106), Jacqueline de Graaf (106), Markus Loeffler (104,105), Florian Kronenberg (103), Dongfeng Gu (101,341), Jeanette Erdmann (98), Heribert Schunkert (99,100), Paul W. Franks (102), Allan Linneberg (79,80), J. Wouter Jukema (96,342), Amit V. Khera (10,343,345,346), Minna Männikkö (346), Marjo-Riitta Jarvelin (62,347,348), Zoltan Kutalik (93,94), Cucca Francesco (349,350), Dennis O. Mook-Kanamori (351,352), Ko Willems van Dijk (353,354,355), Hugh Watkins (87,88), David P. Strachan (356), Niels Grarup (86), Peter Sever (357), Neil Poulter (358), Wayne Huey-Herng Sheu (359,360), Jerome I. Rotter (81), Thomas M. Dantoft (79), Fredrik Karpe (361,362), Matt J. Neville (361,362), Nicholas J. Timpson (33,77), Ching-Yu Cheng (363,364), Tien-Yin Wong (363,364), Chiea Chuen Khor (144), Hengtong Li (365), Charumathi Sabanayagam (363,364), Annette Peters (75,100,366), Christian Gieger (74,75,366), Andrew T. Hattersley (367), Nancy L. Pedersen (368), Patrik K.E. Magnusson (368), Dorret I. Boomsma (70,301), Eco J.C. de Geus (70,301), L. Adrienne Cupples (5,369), Joyce B.J. van Meurs (69,133), Arfan Ikram (133), Mohsen Ghanbari (133,370), Penny Gordon-Larsen (284,285), Wei Huang (371), Young Jin Kim (23), Yasuharu Tabara (68), Nicholas J. Wareham (66), Claudia Langenberg (66), Eleftheria Zeggini (45,207,372), Jaakko Tuomilehto (37,336,373), Johanna Kuusisto (374), Markku Laakso (374), Erik Ingelsson (7,65,375,376), Goncalo Abecasis (13,377), John C. Chambers (62,63,64,378), Jaspal S. Kooner (63,64,357,379), Paul S. de Vries (61), Alanna C. Morrison (61), Scott Hazelhurst (59,380), Michèle Ramsay (59), Kari E. North (58), Martha Daviglus (381), Peter Kraft (57,382), Nicholas G. Martin (383), John B. Whitfield (383), Shahid Abbas (53), Danish Saleheen (53,384,385), Robin G. Walters (51,52,386), Michael V. Holmes (51,52,362), Corri Black (387), Blair H. Smith (319), Aris Baras (377), Anne E. Justice (388), Julie E. Buring (48,310), Paul M. Ridker (48,310), Daniel I. Chasman (48,310), Charles Kooperberg (47), Gen Tamiya (44), Masayuki Yamamoto (44), David A. van Heel (46), Richard C. Trembath (389), Wei-Qi Wei (390), Gail P. Jarvik (391), Bahram Namjou (392), M. Geoffrey Hayes (39,393,394), Marylyn D. Ritchie (38), Pekka Jousilahti (37), Veikko Salomaa (37), Kristian Hveem (32,395,396), Bjørn Olav Åsvold (32,395,397), Michiaki Kubo (398), Yoichiro Kamatani (24,399), Yukinori Okada (24,26,400,401), Yoshinori Murakami (402), Bong-Jo Kim (403), Unnur Thorsteinsdottir (20,324), Kari Stefansson (20,324), Jifeng Zhang (3), Y. Eugene Chen (3), Yuk-Lam Ho (404), Julie A. Lynch (405,406), Philip S. Tsao (6,7,408), Kyong-Mi Chang (328,407), Kelly Cho (404,409), Christopher J. O'Donnell (404,409), John M. Gaziano (404,409), Peter Wilson (17,410), Karen L. Mohlke (168), Timothy M. Frayling (72), Joel N. Hirschhorn (9,10,411), Sekar Kathiresan (10,344,345), Michael Boehnke (13), Struan Grant (1,340), Pradeep Natarajan (10,343,412,413), Yan V. Sun (16,17), Andrew P. Morris (414), Panos Deloukas (4,415), Gina Peloso (5), Themistocles L. Assimes (6,7,408), Cristen J. Willer (3,14,416), Xiang Zhu [xiangzhu@psu.edu] (6,417,418,419,*), Christopher D. Brown [chrbro@upenn.edu] (1,**)

MATURITY onset diabetes of the young, GRANULE cells, INSULIN, STEM cells, and INTRACELLULAR calcium

Mutations in HNF1A cause Maturity Onset Diabetes of the Young (HNF1A-MODY). To understand mechanisms of β-cell dysfunction, we generated stem cell-derived pancreatic endocrine cells with hypomorphic mutations in HNF1A. HNF1A-deficient β-cells display impaired basal and glucose stimulated-insulin secretion, reduced intracellular calcium levels in association with a reduction in CACNA1A expression, and accumulation of abnormal insulin granules in association with SYT13 down-regulation. Knockout of CACNA1A and SYT13 reproduce the relevant phenotypes. In HNF1A deficient β-cells, glibenclamide, a sulfonylurea drug used in the treatment of HNF1A-MODY patients, increases intracellular calcium, and restores insulin secretion. While insulin secretion defects are constitutive in β-cells null for HNF1A, β-cells heterozygous for hypomorphic HNF1A (R200Q) mutations lose the ability to secrete insulin gradually; this phenotype is prevented by correction of the mutation. Our studies illuminate the molecular basis for the efficacy of treatment of HNF1A-MODY with sulfonylureas, and suggest promise for the use of cell therapies. hPSCs model of Maturity Onset Diabetes of the Young caused by mutations in the transcription factor HNF1A (HNF1A-MODY), regulates the expression of genes required for the formation of dense-core insulin granules and calcium-dependent insulin secretion, demonstrating a basis to treat HNF1A-MODY patients with sulfonylureas. [ABSTRACT FROM AUTHOR]

Aims This study aimed to examine perceived social norms, the effect of parental drinking on these norms, alcohol use in front of children, and how norms and consumption vary based on child age and gender of the parent. Methods A cross-sectional online panel survey was undertaken with n  = 1000 Australian adults (including 670 parents) aged 18–59 years. The survey assessed: alcohol consumption in front of children; normative attitudes towards drinking in the presence of children; and perceived social norms. Results Overall, 33.9% of parents reported drinking a glass of alcohol each day or a couple of times a week, 18.2% reported getting slightly drunk and 7.8% indicated getting visibly drunk each day or a couple of times a week with their children present. In total, 37.5% reported drinking in front of their children at least weekly. Fathers were more likely to drink in front of children than mothers. Most parents deemed drinking small amounts of alcohol in front of children as acceptable but did not accept drunkenness. Respondents were less concerned about a father drinking one or two drinks in front of their children than a mother. Social expectations were not related to child age, but norms related to others' perceived behaviour were. Conclusions Many parents, particularly fathers consume alcohol in front of their children. There is a need to target health promotion strategies to adults and parents consuming in excess of health guidelines, and to the many parents who are consuming alcohol at higher levels in front of their children. [ABSTRACT FROM AUTHOR]

BLACK feminism, HISTORY of feminism, FEMINISM, BLACK feminists, WORLD history, CONVERSATION, and RACISM

This roundtable stems from a Zoom event, "New Directions in Feminism and Global Race Studies (a Book Conversation)" with authors Tiffany N. Florvil, Kaiama L. Glover, Annette K. Joseph-Gabriel, Katherine M. Marino, Robin Mitchell, and Jacqueline-Bethel Tchouta Mougoué, hosted by Samantha Pinto. These scholars discussed their recently published books, which expand how we think about transnational feminism and global Black feminisms in the Americas, the Caribbean, Africa, and Europe. The lightly edited transcript of the conversation explores how putting Black women at the center of histories of global feminisms and race studies transforms these fields and the questions that are usually asked. The authors also discussed navigating research challenges and confronting racism in the sources and in the archives. The conversation underscores the importance of intellectual community, as well as the relevance and urgency of Black feminist scholarship today. [ABSTRACT FROM AUTHOR]

Controversial topics may be uncomfortable for teachers to include in their in-class discussions. However, there are considerable cognitive and social-emotional benefits to engagement in controversial conversations, or classroom discussion about controversial topics. It is critical that teachers support students in respectful discussion to help them develop skills such as problem solving, critical thinking, and the ability to consider issues from multiple perspectives. These skills can enable students to meet larger educational goals such as engaged citizenship. The goal of this article is to highlight the benefits of controversial conversations in the classroom and describe teaching approaches that facilitate effective controversial conversations. First, we identify important factors for teachers’ consideration in supporting effective and beneficial controversial conversations. Second, we provide examples of topics of conversations that may be appropriate for students of varying ages. Third, we review how the structure of conversation, scaffolding, classroom context, relationships, and students’ individual differences can shape controversial conversations. [ABSTRACT FROM AUTHOR]

The left atrium is an early sensor of left ventricular (LV) dysfunction. Still, the prognostic value of left atrial (LA) function (strain) on cardiac magnetic resonance (CMR) in dilated cardiomyopathy (DCM) remains unknown. The goal of this study was to evaluate the prognostic value of CMR-derived LA strain in DCM. Patients with DCM from the Maastricht Cardiomyopathy Registry with available CMR imaging were included. The primary endpoint was the combination of sudden or cardiac death, heart failure (HF) hospitalization, or life-threatening arrhythmias. Given the nonlinearity of continuous variables, cubic spline analysis was performed to dichotomize. A total of 488 patients with DCM were included (median age: 54 [IQR: 46-62] years; 61% male). Seventy patients (14%) reached the primary endpoint (median follow-up: 6 [IQR: 4-9] years). Age, New York Heart Association (NYHA) functional class >II, presence of late gadolinium enhancement (LGE), LV ejection fraction (LVEF), LA volume index (LAVI), LV global longitudinal strain (GLS), and LA reservoir and conduit strain were univariably associated with the outcome (all P < 0.02). LA conduit strain was a stronger predictor of outcome compared with reservoir strain. LA conduit strain, NYHA functional class >II, and LGE remained associated in the multivariable model (LA conduit strain HR: 3.65 [95% CI: 2.01-6.64; P < 0.001]; NYHA functional class >II HR: 1.81 [95% CI: 1.05-3.12; P = 0.033]; and LGE HR: 2.33 [95% CI: 1.42-3.85; P < 0.001]), whereas age, N-terminal pro–B-type natriuretic peptide, LVEF, left atrial ejection fraction, LAVI, and LV GLS were not. Adding LA conduit strain to other independent predictors (NYHA functional class and LGE) significantly improved the calibration, accuracy, and reclassification of the prediction model (P < 0.05). LA conduit strain on CMR is a strong independent prognostic predictor in DCM, superior to LV GLS, LVEF, and LAVI and incremental to LGE. Including LA conduit strain in DCM patient management should be considered to improve risk stratification. [Display omitted] [ABSTRACT FROM AUTHOR]

COVID-19, SARS-CoV-2, and REMDESIVIR

Profoundly B-cell-depleted patients can have prolonged severe acute respiratory syndrome coronavirus 2 infections with evidence of active viral replication, due to inability to mount an adequate humoral response to clear the virus. We present 3 B-cell-depleted patients with prolonged coronavirus disease 2019 infection who were successfully treated with a combination of casirivimab/imdevimab and remdesivir. [ABSTRACT FROM AUTHOR]

SOFT robotics, LYMPHEDEMA, SLEEVES, AIR pressure, MICROFLUIDICS, VALVES, MICROFLUIDIC devices, and DRAINAGE

A proof of concept of a novel air microfluidics-enabled soft robotic sleeve to enable lymphedema treatment is presented. Compression sleeves represent the current, suboptimal standard of care, and stationary pumps assist with lymph drainage; however, effective systems that are truly wearable while performing daily activities are very scarce. This problematic trade-off between performance and wearability requires a new solution, which is addressed by an innovative microfluidic device. Its novelty lies in the use of light, small, and inexpensive air microfluidic chips (35 × 20 × 5 mm3 in size) that bring three major advantages compared to their traditional counterparts. First, each chip is designed with 16 fluidic channels with a cross-sectional area varying from 0.04 to 1 mm2, providing sequential inflation and uniform deflation capability to eight air bladders, thereby producing intentional gradient compression to the arm to facilitate lymph fluid circulation. The design is derived from the fundamentals of microfluidics, in particular, hydraulic resistance and paths of least resistance. Second, the air microfluidic chip enables miniaturization of at least eight bulky energy-consuming valves to two miniature solenoid valves for control increasing wearability. Third, the air microfluidic chip has no moving parts, which reduces the noise and energy needed. The cost, simplicity, and scale-up potential of developing methods for making the system are also detailed. The sequential inflation, uniform deflation, and pressure gradient are demonstrated, and the resulted compression and internal air bladder pressure were evaluated. This air microfluidics-enabled sleeve presents tremendous potential toward future improvements in self-care lymphedema management. [ABSTRACT FROM AUTHOR]

COMMUNICABLE diseases, INFECTIOUS arthritis, HOSPITAL patients, CELLULITIS, DRUG abuse, DRUGS, and FISHER exact test

Injection drug use poses a public health challenge. Clinical experience indicates that people who inject drugs (PWID) are hospitalized frequently for infectious diseases, but little is known about outcomes when admitted. Charts were identified from local hospitals between 2013–2018 using consultation lists and hospital record searches. Included individuals injected drugs in the past six months and presented with infection. Charts were accessed using the hospital information system, undergoing primary and secondary reviews using Research Electronic Data Capture (REDCap). The Wilcoxon rank-sum test was used for comparisons between outcome categories. Categorical data were summarized as count and frequency, and compared using Fisher's exact test. Of 240 individuals, 33% were admitted to the intensive care unit, 36% underwent surgery, 12% left against medical advice (AMA), and 9% died. Infectious diagnoses included bacteremia (31%), abscess (29%), endocarditis (29%), cellulitis (20%), sepsis (10%), osteomyelitis (9%), septic arthritis (8%), pneumonia (7%), discitis (2%), meningitis/encephalitis (2%), or other (7%). Sixty-six percent had stable housing and 60% had a family physician. Fifty-four percent of patient-initiated discharges were seen in the emergency department within 30 days and 29% were readmitted. PWID are at risk for infections. Understanding their healthcare trajectory is essential to improve their care. [ABSTRACT FROM AUTHOR]

Heterologous vaccination (“mixing platforms”) for the third (D3) dose of SARS‐CoV‐2 vaccine is a potential strategy to improve antibody responses in solid organ transplant recipients (SOTRs), but data are mixed regarding potential differential immunogenicity. We assessed for differences in immunogenicity and tolerability of homologous (BNT162b2 or mRNA‐1273; D3‐mRNA) versus heterologous (Ad.26.COV2.S; D3‐JJ) D3 among 377 SARS‐CoV‐2‐infection naïve SOTRs who remained seronegative after two mRNA vaccines. We measured anti‐spike titers and used weighted Poisson regression to evaluate seroconversion and development of high‐titers, comparing D3‐JJ to D3‐mRNA, at 1‐, 3‐, and 6 month post‐D3. 1‐month post‐D3, seroconversion (63% vs. 52%, p = .3) and development of high‐titers (29% vs. 25%, p = .7) were comparable between D3‐JJ and D3‐mRNA recipients. 3 month post‐D3, D3‐JJ recipients were 1.4‐fold more likely to seroconvert (80% vs. 57%, weighted incidence‐rate‐ratio: wIRR = 1.101.401.77, p = .006) but not more likely to develop high‐titers (27% vs. 22%, wIRR = 0.440.921.93, p = .8). 6 month post‐D3, D3‐JJ recipients were 1.41‐fold more likely to seroconvert (88% vs. 59%, wIRR = 1.04 1.411.93, p = .029) and 2.63‐fold more likely to develop high‐titers (59% vs. 21%, wIRR = 1.382.635.00, p = .003). There was no differential signal in alloimmune events or reactogenicity between platforms. SOTRs without antibody response after two mRNA vaccines may derive benefit from heterologous Ad.26.COV2.S D3. [ABSTRACT FROM AUTHOR]

COVID-19, SEDENTARY behavior, PHYSICAL activity, HOSPITAL care, and PATIENTS' attitudes

Many patients with COVID-19 experience severe and even fatal disease. Survivors may have long-term health consequences, but data on physical activity and sedentary behaviour are scarce. Therefore, we objectively assessed physical activity (PA) patterns among post-hospitalised patients with COVID-19 and explored associations with patient characteristics, disease severity and cardiac dysfunction. We objectively assessed PA, sedentary behaviour and sleep duration for 24 h/day during 8 days at 3-6 months after COVID-19 hospitalisation. PA and sedentary time were compared across pre-defined subgroups based on patient and disease characteristics, cardiac biomarker release during hospitalisation, abnormal transthoracic echocardiogram at 3-6 months post-hospitalisation and persistence of symptoms post-discharge. PA and sedentary behaviour were assessed in 37 patients (60 ± 10 years old; 78% male). Patients spent 4.2 [3.2; 5.3] h/day light-intensity PA and 1.0 [0.8; 1.4] h/day moderate-to-vigorous intensity PA. Time spent sitting was 9.8 [8.7; 11.2] h/day, which was accumulated in 6 [5; 7] prolonged sitting bouts (≥30 min) and 41 [32; 48] short sitting bouts (<30 min). No differences in PA and sedentary behaviour were found across subgroups, but sleep duration was higher in patients with versus without persistent symptoms (9.1 vs. 8.3 h/day, p = 0.02). Taken together, high levels of sedentary time are common at 3–6 months after COVID-19 hospitalisation, whilst PA and sedentary behaviour are not impacted by patient or disease characteristics. [ABSTRACT FROM AUTHOR]

DISABILITY awareness, PEOPLE with social disabilities, PEOPLE with disabilities, CRITICAL thinking, RESEARCH personnel, and STRATEGIC planning

Objective: The main objectives were to 1) search and map current disability awareness and training activities in Quebec, Canada, 2) collectively reflect on these practices, and 3) develop a five-year strategic plan.Methods: We used an integrated knowledge translation approach whereby researchers and community partners were involved in all stages. This project consisted of two sequential phases: 1) an environmental scan (web review and interview) of current practices, and 2) a reflection process with an external expert-facilitator in social transformation. Outcome results and process data are reported.Results: We identified 129 activities (71 training, 58 awareness) from 39 organizations (from 123 organizations initially invited). A wide range of characteristics were collected for each activity which allowed for the identification of gaps. The working group met seven times in one year to discuss results from phase 1 and co-create a five-year strategic plan. Main priorities are 1) the development of a methodology for measuring collective impact and 2) content synchronization of activities.Conclusion: Involvement of partners and researchers enabled a concerted and efficient approach to the development of a five-year strategic plan.Practice Implications: A transition committee led by partners will ensure implementation and sustainability of the plan across the province. [ABSTRACT FROM AUTHOR]