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1. d-Amino acids: new clinical pathways for brain diseases. [2023]

  • Souza, Isis Nem de Oliveira, Roychaudhuri, Robin, de Belleroche, Jacqueline, and Mothet, Jean-Pierre
  • Trends in Molecular Medicine. Dec2023, Vol. 29 Issue 12, p1014-1028. 15p.
Subjects
BRAIN diseases, ALZHEIMER'S disease, AMYOTROPHIC lateral sclerosis, CENTRAL nervous system, ENDOCRINE system, and CYSTEINE
Abstract
d -Amino acids (d- AAs) form a novel class of vital signaling molecules that control brain homeostasis. Abnormal d -AAs levels in biofluids and tissues occur in various brain disorders. d -AAs can be used as biomarkers for disease diagnosis, prognosis, and treatment monitoring. d -AA signaling and metabolic pathways are promising druggable targets for chronic and acute neuropathologies. Free d -amino acids (d -AAs) are emerging as a novel and important class of signaling molecules in many organs, including the brain and endocrine systems. There has been considerable progress in our understanding of the fundamental roles of these atypical messengers, with increasingly recognized implications in a wide range of neuropathologies, including schizophrenia (SCZ), epilepsy, Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), substance abuse, and chronic pain, among others. Research has enabled the discovery that d -serine, d -aspartate and more recently d -cysteine are essential for the healthy development and function of the central nervous system (CNS). We discuss recent progress that has profoundly transformed our vision of numerous physiological processes but has also shown how d -AAs are now offering therapeutic promise in clinical settings for several human diseases. [ABSTRACT FROM AUTHOR]

2. Patient‐reported outcome measures and patient engagement in heart failure clinical trials: multi‐stakeholder perspectives. [2023]

  • Zannad, Faiez, Alikhaani, Jacqueline, Alikhaani, Sadegh, Butler, Javed, Gordon, Jason, Jensen, Klaus, Khatib, Rani, Mantovani, Lorenzo, Martinez, Robin, Moore, Wanda F., Murakami, Masahiro, Roessig, Lothar, Stockbridge, Norman, Van Spall, Harriette G.C., Yancy, Clyde, and Spertus, John A.
  • European Journal of Heart Failure. Apr2023, Vol. 25 Issue 4, p478-487. 10p. 1 Diagram, 2 Charts, 1 Graph.
Subjects
HEART failure patients, PATIENT reported outcome measures, PATIENTS' attitudes, CLINICAL trials, HEART failure, and QUALITY of life
Abstract
There are many consequences of heart failure (HF), including symptoms, impaired health‐related quality of life (HRQoL), and physical and social limitations (functional status). These have a substantial impact on patients' lives, yet are not routinely captured in clinical trials. Patient‐reported outcomes (PROs) can quantify patients' experiences of their disease and its treatment. Steps can be taken to improve the use of PROs in HF trials, in regulatory and payer decisions, and in patient care. Importantly, PRO measures (PROMs) must be developed with involvement of patients, family members, and caregivers from diverse demographic groups and communities. PRO data collection should become more routine not only in clinical trials but also in clinical practice. This may be facilitated by the use of digital tools and interdisciplinary patient advocacy efforts. There is a need for standardization, not only of the PROM instruments, but also in procedures for analysis, interpretation and reporting PRO data. More work needs to be done to determine the degree of change that is important to patients and that is associated with increased risks of clinical events. This 'minimal clinically important difference' requires further research to determine thresholds for different PROMs, to assess consistency across trial populations, and to define standards for improvement that warrant regulatory and reimbursement approvals. PROs are a vital part of patient care and drug development, and more work should be done to ensure that these measures are both reflective of the patient experience and that they are more widely employed. [ABSTRACT FROM AUTHOR]

3. Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial. [2023]

  • Daix, Thomas, Mathonnet, Armelle, Brakenridge, Scott, Dequin, Pierre-François, Mira, Jean-Paul, Berbille, Frederique, Morre, Michel, Jeannet, Robin, Blood, Teresa, Unsinger, Jacqueline, Blood, Jane, Walton, Andrew, Moldawer, Lyle L., Hotchkiss, Richard, and François, Bruno
  • Annals of Intensive Care. 3/12/2023, Vol. 13 Issue 1, p1-11. 11p.
Subjects
SEPTIC shock, INTERLEUKIN-7, LYMPHOCYTE count, LYMPHOPENIA, T cells, and INTRAVENOUS therapy
Abstract
Background: Profound lymphopenia is an independent predictor of adverse clinical outcomes in sepsis. Interleukin-7 (IL-7) is essential for lymphocyte proliferation and survival. A previous phase II study showed that CYT107, a glycosylated recombinant human IL-7, administered intramuscularly reversed sepsis-induced lymphopenia and improved lymphocyte function. Thepresent study evaluated intravenous administration of CYT107. This prospective, double-blinded, placebo-controlled trial was designed to enroll 40 sepsis patients, randomized 3:1 to CYT107 (10 µg/kg) or placebo, for up to 90 days. Results: Twenty-one patients were enrolled (fifteen CYT107 group, six placebo group) at eight French and two US sites. The study was halted early because three of fifteen patients receiving intravenous CYT107 developed fever and respiratory distress approximately 5–8 h after drug administration. Intravenous administration of CYT107 resulted in a two–threefold increase in absolute lymphocyte counts (including in both CD4+ and CD8+ T cells (all p < 0.05)) compared to placebo. This increase was similar to that seen with intramuscular administration of CYT107, was maintained throughout follow-up, reversed severe lymphopenia and was associated with increase in organ support free days (OSFD). However, intravenous CYT107 produced an approximately 100-fold increase in CYT107 blood concentration compared with intramuscular CYT107. No cytokine storm and no formation of antibodies to CYT107 were observed. Conclusion: Intravenous CYT107 reversed sepsis-induced lymphopenia. However, compared to intramuscular CYT107 administration, it was associated with transient respiratory distress without long-term sequelae. Because of equivalent positive laboratory and clinical responses, more favorable pharmacokinetics, and better patient tolerability, intramuscular administration of CYT107 is preferable. Trial registration: Clinicaltrials.gov, NCT03821038. Registered 29 January 2019, https://clinicaltrials.gov/ct2/show/NCT03821038?term=NCT03821038&draw=2&rank=1. [ABSTRACT FROM AUTHOR]

4. Patterns of failure in pediatric medulloblastoma and implications for hippocampal sparing. [2023]

  • Baliga, Sujith, Adams, Judith A., Bajaj, Benjamin V. M., Van Benthuysen, Liam, Daartz, Juliane, Gallotto, Sara L., Lewy, Jacqueline R., DeNunzio, Nicholas, Weyman, Elizabeth A., Lawell, Miranda P., Palmer, Joshua D., Yeap, Beow Y., Ebb, David H., Huang, Mary S., Perry, Alisa F., MacDonald, Shannon M., Jones, Robin M., Tarbell, Nancy J., and Yock, Torunn I.
  • Cancer (0008543X). Mar2023, Vol. 129 Issue 5, p764-770. 7p.
Subjects
MEDULLOBLASTOMA, HIPPOCAMPUS (Brain), CHILD patients, VOLUMETRIC-modulated arc therapy, BRAIN tumors, and SUBSTANCE abuse relapse
Abstract
Background: Hippocampal avoidance (HA) has been shown to preserve cognitive function in adult patients with cancer treated with whole‐brain radiation therapy for brain metastases. However, the feasibility of HA in pediatric patients with brain tumors has not been explored because of concerns of increased risk of relapse in the peri‐hippocampal region. Our aim was to determine patterns of recurrence and incidence of peri‐hippocampal relapse in pediatric patients with medulloblastoma (MB). Methods and materials: We identified pediatric patients with MB treated with protons between 2002 and 2016 and who had recurrent disease. To estimate the risk of peri‐hippocampal recurrence, three hippocampal zones (HZs) were delineated corresponding to ≤5 mm (HZ‐1), 6 to 10 mm (HZ‐2), and >10 mm (HZ‐3) distance of the recurrence from the contoured hippocampi. To determine the feasibility of HA, three standard‐risk patients with MB were planned using either volumetric‐modulated arc therapy (VMAT) or intensity‐modulated proton therapy (IMPT) plans. Results: Thirty‐eight patients developed a recurrence at a median of 1.6 years. Of the 25 patients who had magnetic resonance imaging of the recurrence, no patients failed within the hippocampus and only two patients failed within HZ‐1. The crude incidence of peri‐hippocampal failure was 8%. Both HA‐VMAT and HA‐IMPT plans were associated with significantly reduced mean dose to the hippocampi (p <.05). HA‐VMAT and HA‐IMPT plans were associated with decreased percentage of the third and lateral ventricles receiving the prescription craniospinal dose of 23.4 Gy. Conclusions: Peri‐hippocampal failures are uncommon in pediatric patients with MB. Hippocampal avoidance should be evaluated in a prospective cohort of pediatric patients with MB. Plain Language Summary: In this study, the patterns of disease recurrence in patients with a pediatric brain tumor known as medulloblastoma treated with proton radiotherapy were examined. The majority of failures occur outside of an important structure related to memory formation called the hippocampus. Hippocampal sparing radiation plans using proton radiotherapy were generated and showed that dose to the hippocampus was able to be significantly reduced. The study provides the rationale to explore hippocampal sparing in pediatric medulloblastoma in a prospective clinical trial. The incidence of peri‐hippocampal failures in patients treated with proton radiotherapy for pediatric medulloblastoma was 8%.Hippocampal sparing plans were associated with significant reduction in the mean dose to the right and left hippocampi. [ABSTRACT FROM AUTHOR]

5. Implementation of a Web-Based Communication System for Primary Care Providers and Cancer Specialists. [2023]

  • Petrovic, Bojana, Bender, Jacqueline L., Liddy, Clare, Afkham, Amir, McGee, Sharon F., Morgan, Scott C., Segal, Roanne, O'Brien, Mary Ann, Julian, Jim A., Sussman, Jonathan, Urquhart, Robin, Fitch, Margaret, Schneider, Nancy D., and Grunfeld, Eva
  • Current Oncology. Mar2023, Vol. 30 Issue 3, p3537-3548. 12p. 2 Charts, 2 Graphs.
Subjects
TELECOMMUNICATION, DIGITAL technology, PRIMARY care, ONCOLOGISTS, and ELECTRONIC health records
Abstract
Healthcare providers have reported challenges with coordinating care for patients with cancer. Digital technology tools have brought new possibilities for improving care coordination. A web- and text-based asynchronous system (eOncoNote) was implemented in Ottawa, Canada for cancer specialists and primary care providers (PCPs). This study aimed to examine PCPs' experiences of implementing eOncoNote and how access to the system influenced communication between PCPs and cancer specialists. As part of a larger study, we collected and analyzed system usage data and administered an end-of-discussion survey to understand the perceived value of using eOncoNote. eOncoNote data were analyzed for 76 shared patients (33 patients receiving treatment and 43 patients in the survivorship phase). Thirty-nine percent of the PCPs responded to the cancer specialist's initial eOncoNote message and nearly all of those sent only one message. Forty-five percent of the PCPs completed the survey. Most PCPs reported no additional benefits of using eOncoNote and emphasized the need for electronic medical record (EMR) integration. Over half of the PCPs indicated that eOncoNote could be a helpful service if they had questions about a patient. Future research should examine opportunities for EMR integration and whether additional interventions could support communication between PCPs and cancer specialists. [ABSTRACT FROM AUTHOR]

6. Kinetics of the Antibody Response to Symptomatic SARS-CoV-2 Infection in Vaccinated and Unvaccinated Individuals in the Blinded Phase of the mRNA-1273 COVID-19 Vaccine Efficacy Trial. [2023]

  • Follmann, Dean, Janes, Holly E, Chu, Eric, Jayashankar, Lakshmi, Petropoulos, Christos J, Serebryannyy, Leonid, Carroll, Robin, Jean-Baptiste, Naz, Narpala, Sandeep, Lin, Bob C, McDermott, Adrian, Novak, Richard M, Graciaa, Daniel S, Rolsma, Stephanie, Magaret, Craig A, Doria-Rose, Nicole, Corey, Lawrence, Neuzil, Kathleen M, Pajon, Rolando, and Miller, Jacqueline M
  • Open Forum Infectious Diseases. Mar2023, Vol. 10 Issue 3, p1-8. 8p.
Abstract
Background Hybrid immunity is associated with more durable protection against coronavirus disease 2019 (COVID-19). We describe the antibody responses following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in vaccinated and unvaccinated individuals. Methods The 55 vaccine arm COVID-19 cases diagnosed during the blinded phase of the Coronavirus Efficacy trial were matched with 55 placebo arm COVID-19 cases. Pseudovirus neutralizing antibody (nAb) activity to the ancestral strain and binding antibody (bAb) responses to nucleocapsid and spike antigens (ancestral and variants of concern [VOCs]) were assessed on disease day 1 (DD1) and 28 days later (DD29). Results The primary analysis set was 46 vaccine cases and 49 placebo cases with COVID-19 at least 57 days post–first dose. For vaccine group cases, there was a 1.88-fold rise in ancestral antispike bAbs 1 month post–disease onset, although 47% had no increase. The vaccine-to-placebo geometric mean ratios for DD29 antispike and antinucleocapsid bAbs were 6.9 and 0.04, respectively. DD29 mean bAb levels were higher for vaccine vs placebo cases for all VOCs. DD1 nasal viral load positively correlated with bAb levels in the vaccine group. Conclusions Following COVID-19, vaccinated participants had higher levels and greater breadth of antispike bAbs and higher nAb titers than unvaccinated participants. These were largely attributable to the primary immunization series. [ABSTRACT FROM AUTHOR]

7. Evaluation of left cardiac chamber function with cardiac magnetic resonance and association with outcome in patients with systemic sclerosis. [2023]

  • Butcher, Steele C, Vos, Jacqueline L, Fortuni, Federico, Galloo, Xavier, Liem, Sophie I E, Bax, Jeroen J, Delgado, Victoria, Vonk, Madelon C, Leuven, Sander I van, Snoeren, Miranda, Messaoudi, Saloua El, Vries-Bouwstra, Jeska K de, Nijveldt, Robin, and Marsan, Nina Ajmone
  • Rheumatology. 2023 Supplement, Vol. 62, pSI20-SI31. 12p.
Subjects
LEFT heart ventricle, PATIENT aftercare, CAUSES of death, CONFIDENCE intervals, MAGNETIC resonance imaging, GLOBAL longitudinal strain, SYSTEMIC scleroderma, TERTIARY care, DESCRIPTIVE statistics, RESEARCH funding, LOGISTIC regression analysis, ODDS ratio, LEFT heart atrium, HEART failure, and PROPORTIONAL hazards models
Abstract
Objective This study aimed to determine whether lower values of feature-tracking cardiovascular magnetic resonance (CMR)-derived left atrial reservoir strain (LARS) and impaired left ventricular (LV) global longitudinal strain (GLS) were associated with the presence of symptoms and long-term prognosis in patients with SSc. Methods A total of 100 patients {54 [interquartile range (IQR) 46–64] years, 42% male} with SSc who underwent CMR imaging at two tertiary referral centres were included. All patients underwent analysis of LARS and LV GLS using feature-tracking on CMR and were followed-up for the occurrence of all-cause mortality. Results The median LV GLS was –21.8% and the median LARS was 36%. On multivariable logistic regression, LARS [odds ratio (OR) 0.964 per %, 95% CI 0.929, 0.998, P  = 0.049] was independently associated with New York Heart Association (NYHA) class II–IV heart failure symptoms. Over a median follow-up of 37 (21–62) months, a total of 24 (24%) patients died. Univariable Cox regression analysis demonstrated that LARS [hazard ratio (HR) 0.94 per 1%, 95% CI 0.91, 0.97, P  < 0.0001) and LV GLS (HR 1.10 per %, 95% CI 1.03, 1.17, P  = 0.005) were associated with all-cause mortality, while LV ejection fraction was not. Likelihood ratio tests demonstrated that LARS provided incremental value over prognostically important clinical and imaging parameters, including late gadolinium enhancement. Conclusion In patients with SSc, LARS was independently associated with the presence of NYHA class II–IV heart failure symptoms. Although both LARS and LV GLS were associated with all-cause mortality, only LARS provided incremental value over all evaluated variables known to be prognostically important in patients with SSc. [ABSTRACT FROM AUTHOR]

8. A phase 1b study of venetoclax and azacitidine combination in patients with relapsed or refractory myelodysplastic syndromes [2023]

  • Zeidan, Amer M., Borate, Uma, Pollyea, Daniel A., Brunner, Andrew M., Roncolato, Fernando, Garcia, Jacqueline S., Filshie, Robin, Odenike, Olatoyosi, Watson, Anne Marie, Krishnadasan, Ravitharan, Bajel, Ashish, Naqvi, Kiran, Zha, Jiuhong, Cheng, Wei‐Han, Zhou, Ying, Hoffman, David, Harb, Jason G., Potluri, Jalaja, and Garcia‐Manero, Guillermo
  • American journal of hematology. 98(2):272-281

9. 6‐month antibody kinetics and durability after four doses of a SARS‐CoV‐2 vaccine in solid organ transplant recipients [2023]

  • Mitchell, Jonathan, Chiang, Teresa PY, Alejo, Jennifer L., Kim, Jake D., Chang, Amy, Abedon, Aura T., Avery, Robin K., Tobian, Aaron A. R., Levan, Macey L., Warren, Daniel S., Garonzik‐Wang, Jacqueline M., Segev, Dorry L., Massie, Allan B., and Werbel, William A.
  • Clinical transplantation. 37(1)

10. MP-453090-9 FINDINGS FROM TWELVE YEARS OF FAMILY SCREENING AFTER SUDDEN CARDIAC DEATH [2023]

  • Brown, Stewart, Bailey, Janice, Wang, Robin, Kemp, Jacqueline, Strawbridge, Martyn, Sheppard, Mary, Dayer, Mark J., and Furniss, Guy O.
  • Heart rhythm. 20(S):S117-S118

11. Left Atrial Strain Is an Independent Predictor of New-Onset Atrial Fibrillation in Dilated Cardiomyopathy [2023]

  • Raafs, Anne G., Vos, Jacqueline L., Henkens, Michiel T.H.M., Verdonschot, Job A.J., Sikking, Maurits, Stroeks, Sophie, Gerretsen, Suzanne, Hazebroek, Mark R., Knackstedt, Christian, Nijveldt, Robin, and Heymans, Stephane R.B.
  • JACC.Cardiovascular imaging. 16(7):991-992

12. Vergence/accommodative therapy for symptomatic convergence insufficiency in children: Time course of improvements in convergence function [2023]

  • Jenewein, Erin C., Cotter, Susan, Roberts, Tawna, Kulp, Marjean, Mitchell, G. Lynn, Jones‐Jordan, Lisa A., Chen, Angela M., Hopkins, Kristine, Huang, Kristine, Amster, Deborah, Fecho, Gregory, Tyler, Julie, Meiyeppen, Shivakhaami, Scheiman, Mitchell, Cooper, Jeffrey, Schulman, Erica, Hamian, Kimberly, Iacono, Danielle, Larson, Steven, Leung, Valerie, Meeder, Sara, Ramos, Elaine, Ritter, Steven, Steiner, Audra, Stormann, Alexandria, Vricella, Marilyn, Zhu, Xiaoying, Tamkins, Susanna, Aguilera, Naomi, Brafman, Elliot, Capo, Hilda, Cavuoto, Kara, Crespo, Isaura, Dowling, Monica, Draskovic, Kristie, Farag, Miriam, Fischer, Vicky, Grace, Sara, Gutierrez, Ailen, Manchola‐Orozco, Carolina, Martinez, Maria, McKeown, Craig, Osigian, Carla, Pham, Tuyet‐Suong, Small, Leslie, Townsend, Natalie, Gallaway, Michael, Boas, Mark, Calvert, Christine, Franz, Tara, Gerrouge, Amanda, Hayden, Donna, Margolies, Zachary, Myung, Jenny, Pollack, Karen, Shoge, Ruth, Tang, Andrew, Tannen, Noah, Trieu, Lynn, Trujillo, Luis, Buckland, Michelle, Ellis, Allison, Fogt, Jennifer, McDaniel, Catherine, McGann, Taylor, Morrison, Ann, Mulvihill, Shane, Peiffer, Adam, Plaumann, Maureen, Pierce, Gil, Preston, Julie, Reuter, Kathleen, Stevens, Nancy, Teeny, Jake, Toole, Andrew, Widmer, Douglas, Zimmerman, Aaron, Barnhardt, Carmen, Borsting, Eric, Chu, Raymond, Parker, Susan, Retnasothie, Dashaini, Wu, Judith, Hertle, Richard, Clark, Penny, Culp, Kelly, Fraley, Kathy, Grant, Drusilla, Hanna, Nancy, Knox, Stephanie, Lawhon, William, Li, Lan, Mitcheff, Sarah, Ricker, Isabel, Solis, Casandra, Wall, Palak, Zaczyk, Samantha, Marsh‐Tootle, Wendy, Bowen, Michelle, Call, Terri, Domnanovich, Kristy, Frazier, Marcela, Guyette, Nicole, Hayes, Oakley, Houser, John, Lee, Sarah, Montejo, Jenifer, Oechslin, Tamara, Turner, Candace, Weise, Katherine, Coulter, Rachel, Bade, Annette, Bansal, Surbhi, Falco, Laura, Green, Katherine, Irizarry, Gabriela, Jhajj, Jasleen, Patterson, Nicole, Rodena, Jacqueline, Tea, Yin, Weiss, Dana, Zakaib, Lauren, Lorenzana, Ingryd, Meza, Yesena, Mann, Ryan, Quezada, Mariana, Rein, Scott, Rudaitis, Indre, Stepleton, Susan, Wajs, Beata, Redford, Maryann, Denton, Carolyn, Arnold, Eugene, Chase, Christopher, Wee, Sharyl, Dahl‐Leonard, Katlynn, Powers, Kenneth, Alaniz, Amber, Diener‐West, Marie, Good, William V., Grisham, David, Kratochvil, Christopher J., Revicki, Dennis, Wanzek, Jeanne, Abraham, Mustafa, Dangelo, Julianne, Hegedus, Jordan, Jones, Ian, Junglas, Alexander, Lee, Jihyun, Nettles, Jadin, Mitchell, Curtis, Osman, Mawada, Scott‐Tibbs, Gloria, Sinnott, Loraine, Teasley, Chloe, Vang, Victor, and Varghese, Robin
  • Ophthalmic and physiological optics. 43(1):105-115

13. Antibody response to a third dose of SARS‐CoV‐2 vaccine in heart and lung transplant recipients. [2022]

  • Alejo, Jennifer L., Ruck, Jessica M., Chiang, Teresa P. Y., Abedon, Aura T., Kim, Jake D., Avery, Robin K., Tobian, Aaron A. R., Warren, Daniel S., Levan, Macey L., Massie, Allan B., Garonzik‐Wang, Jacqueline M., Segev, Dorry L., and Werbel, William A.
  • Clinical Transplantation. Nov2022, Vol. 36 Issue 11, p1-3. 3p.
Subjects
COVID-19 vaccines, ANTIBODY formation, HEART transplant recipients, LUNG transplantation, HIV seroconversion, and BOOSTER vaccines
Abstract
Antibody response to a third dose of SARS-CoV-2 vaccine in heart and lung transplant recipients Morbidity and mortality from SARS-CoV-2 infection in heart (HT) and lung transplant (LT) recipients are high, especially for LT recipients, despite vaccination.[1] Despite severe COVID-19 outcomes, HT/LT recipients represent <10% of solid organ transplant recipients (SOTRs) included in cohort studies evaluating two and three dose regimens.[2] There is now strong evidence to support that SOTRs in a greater immunosuppressed state (common among HT/LT recipients) are at increased risk for persistent seronegative state post-D3.[[3]] Therefore, we evaluated antispike antibody responses before and after a third vaccine dose (D3) in HT/LT recipients to quantify post-D3 antibody responses. Effect of Mycophenolate mofetil dosing on antibody response to SARS-CoV-2 vaccination in heart and lung transplant recipients. [Extracted from the article]

14. Patient and Healthcare Provider Perspectives on the Implementation of a Web-Based Clinical Communication System for Cancer: A Qualitative Study. [2022]

  • Petrovic, Bojana, O'Brien, Mary Ann, Liddy, Clare, Afkham, Amir, McGee, Sharon F., Morgan, Scott C., Segal, Roanne, Bender, Jacqueline L., Sussman, Jonathan, Urquhart, Robin, Fitch, Margaret, Schneider, Nancy D., and Grunfeld, Eva
  • Current Oncology. Nov2022, Vol. 29 Issue 11, p8401-8414. 14p. 1 Diagram, 2 Charts.
Subjects
TELECOMMUNICATION, CANCER, PRIMARY care, ELECTRONIC health records, and MEDICAL personnel
Abstract
Previous research has identified communication and care coordination problems for patients with cancer. Healthcare providers (HCPs) have reported communication issues due to the incompatibility of electronic medical records (EMR) software and not being consistently copied on patient reports. We evaluated an asynchronous web-based communication system ("eOncoNote") for primary care providers and cancer specialists to improve cancer care coordination. The objectives were to examine patients' perceptions of the role of eOncoNote in their healthcare, and HCPs' experiences of implementing eOncoNote. Qualitative interviews were conducted with patients with breast and prostate cancer, primary care providers, and cancer specialists. Eighteen patients and fourteen HCPs participated. Six themes were identified from the patient interviews focusing on HCP and patient roles related to care coordination and patient awareness of communication among their HCPs. Four themes were identified from HCP interviews related to the context of care coordination and experience with eOncoNote. Both patients and HCPs described the important role patients and caregivers play in care coordination. The results show that patients were often unaware of the communication between their HCPs and assumed they were communicating. HCPs encountered challenges incorporating eOncoNote into their workflow. [ABSTRACT FROM AUTHOR]

15. An innovative interprofessional education simulation for athletic training and prelicensure nursing students: Development, implementation, and student perspectives. [2022]

  • Vaughn, Jacqueline, Cunningham, Robin, Schroeder, Lindsey H., Waddill, Colette, Peterson, Matthew J., Gambacorta, Mia Rose, and Sims, Stephanie
  • Nursing Forum. Nov2022, Vol. 57 Issue 6, p1373-1380. 8p.
Subjects
NURSING licensure, OCCUPATIONAL roles, PROFESSIONAL ethics, TEAMS in the workplace, STATISTICS, EVALUATION of human services programs, NURSING, PROFESSIONS, RESEARCH methodology, HUMAN services programs, PRE-tests & post-tests, LEARNING strategies, INTERPROFESSIONAL relations, COMMUNICATION, QUESTIONNAIRES, DESCRIPTIVE statistics, INTERDISCIPLINARY education, NURSING students, STUDENT attitudes, STATISTICAL sampling, DATA analysis software, THEMATIC analysis, and TRAINING of athletic trainers
Abstract
Background: The purpose of this article is to describe the development, implementation, and evaluation of a Simulation Interprofessional Education (Sim‐IPE) activity for healthcare students from different disciplines (athletic training [AT] and nursing). The objective for the Sim‐IPE activity was to engage AT and prelicensure nursing students in a realistic healthcare scenario to enhance knowledge about one another's profession, develop interprofessional skills, collaborate with one another, and communicate effectively as a team as they performed care. Methods: This mixed methods study employed a one‐time posttest design for a convenience sample of AT and prelicensure nursing students following a simulation intervention. Students completed the Student Perceptions of Interprofessional Clinical Education‐Revised (SPICE‐R) survey and answered open‐ended response questions. Results: Thirteen students (N = 13) from Cohort 1 and 12 students (N = 12) from Cohort 2 completed the SPICE‐R survey. Most students strongly agreed/agreed for each of the SPICE‐R survey questions. Qualitative findings indicated the students positively perceived the Sim‐IPE activity as it helped them discover the value of interprofessional patient care. Discussion: The quantitative findings indicated that the students found the Sim‐IPE an effective learning methodology to achieve the objectives while the qualitative findings gave further insight into the students' perceptions of interprofessional teamwork and the value of the prebrief session conducted before the simulation. The findings will inform future Sim‐IPE activities involving additional groups of healthcare students. [ABSTRACT FROM AUTHOR]

16. The impact of Mendelian sleep and circadian genetic variants in a population setting. [2022]

  • Weedon, Michael N., Jones, Samuel E., Lane, Jacqueline M., Lee, Jiwon, Ollila, Hanna M., Dawes, Amy, Tyrrell, Jess, Beaumont, Robin N., Partonen, Timo, Merikanto, Ilona, Rich, Stephen S., Rotter, Jerome I., Frayling, Timothy M., Rutter, Martin K., Redline, Susan, Sofer, Tamar, Saxena, Richa, and Wood, Andrew R.
  • PLoS Genetics. 9/22/2022, Vol. 18 Issue 9, p1-17. 17p.
Subjects
GENETIC variation, SLEEP, MISSENSE mutation, GENETIC testing, CLOCK genes, SLEEP disorders, and EXOMES
Abstract
Rare variants in ten genes have been reported to cause Mendelian sleep conditions characterised by extreme sleep duration or timing. These include familial natural short sleep (ADRB1, DEC2/BHLHE41, GRM1 and NPSR1), advanced sleep phase (PER2, PER3, CRY2, CSNK1D and TIMELESS) and delayed sleep phase (CRY1). The association of variants in these genes with extreme sleep conditions were usually based on clinically ascertained families, and their effects when identified in the population are unknown. We aimed to determine the effects of these variants on sleep traits in large population-based cohorts. We performed genetic association analysis of variants previously reported to be causal for Mendelian sleep and circadian conditions. Analyses were performed using 191,929 individuals with data on sleep and whole-exome or genome-sequence data from 4 population-based studies: UK Biobank, FINRISK, Health-2000-2001, and the Multi-Ethnic Study of Atherosclerosis (MESA). We identified sleep disorders from self-report, hospital and primary care data. We estimated sleep duration and timing measures from self-report and accelerometery data. We identified carriers for 10 out of 12 previously reported pathogenic variants for 8 of the 10 genes. They ranged in frequency from 1 individual with the variant in CSNK1D to 1,574 individuals with a reported variant in the PER3 gene in the UK Biobank. No carriers for variants reported in NPSR1 or PER2 were identified. We found no association between variants analyzed and extreme sleep or circadian phenotypes. Using sleep timing as a proxy measure for sleep phase, only PER3 and CRY1 variants demonstrated association with earlier and later sleep timing, respectively; however, the magnitude of effect was smaller than previously reported (sleep midpoint ~7 mins earlier and ~5 mins later, respectively). We also performed burden tests of protein truncating (PTVs) or rare missense variants for the 10 genes. Only PTVs in PER2 and PER3 were associated with a relevant trait (for example, 64 individuals with a PTV in PER2 had an odds ratio of 4.4 for being "definitely a morning person", P = 4x10-8; and had a 57-minute earlier midpoint sleep, P = 5x10-7). Our results indicate that previously reported variants for Mendelian sleep and circadian conditions are often not highly penetrant when ascertained incidentally from the general population. Author summary: Clinically ascertained family-based studies have previously identified rare genetic variation associated with causing life-long sleep conditions, specifically shorter sleep, and earlier or later sleep timing. However, the effects of previously reported genetic variants on sleep duration and timing when identified incidentally through population-based studies are not known. Here, we take advantage of up to 191,929 individuals from four population-based studies, including the UK Biobank, to estimate the effects of these variants on sleep duration and timing using self-reported and accelerometer-based sleep estimates coupled with sequencing data. Our analysis revealed no association between variants previously reported and extreme sleep conditions. Two variants located in two genes (PER3 and CRY1) showed evidence of association with sleep timing, but their estimated effects (~5 to 7 minutes) on sleep timing are much smaller relative to those previously reported. Our results indicate that previously reported variants are not causal for extreme sleep conditions in the general population. Finally, although we were unable to analyse a previously reported variant in the PER2 gene associated with sleep timing, additional analysis in the UK Biobank revealed carries of protein-truncating variants in this gene have an approximately 1-hour earlier sleep midpoint compared to non-carriers. These population-based estimates are important because of the recent dramatic increase in direct-to-consumer and health service genome-wide genetic testing. [ABSTRACT FROM AUTHOR]

17. Which drinkers have changed their alcohol consumption due to energy content concerns? An Australian survey. [2022]

  • Bowden, Jacqueline, Harrison, Nathan J., Caruso, Joanna, Room, Robin, Pettigrew, Simone, Olver, Ian, and Miller, Caroline
  • BMC Public Health. 9/19/2022, Vol. 22 Issue 1, p1-13. 13p. 3 Charts.
Subjects
ALCOHOL drinking, ENERGY consumption, WARNING labels, INCOME, WEIGHT gain, and CONSUMPTION (Economics)
Abstract
Background: Alcohol is a discretionary, energy dense, dietary component. Compared to non-drinkers, people who consume alcohol report higher total energy intake and may be at increased risk of weight gain, overweight, and obesity, which are key preventable risk factors for illness. However, accurate consumer knowledge of the energy content in alcohol is low. To inform future behaviour change interventions among drinkers, this study investigated individual characteristics associated with changing alcohol consumption due to energy-related concerns.Methods: An online survey was undertaken with 801 Australian adult drinkers (18-59 years, 50.2% female), i.e. who consumed alcohol at least monthly. In addition to demographic and health-related characteristics, participants reported past-year alcohol consumption, past-year reductions in alcohol consumption, frequency of harm minimisation strategy use (when consuming alcohol), and frequency of changing alcohol consumption behaviours because of energy-related concerns.Results: When prompted, 62.5% of participants reported changing alcohol consumption for energy-related reasons at least 'sometimes'. Women, those aged 30-44 years, metropolitan residents, those with household income $80,001-120,000, and risky/more frequent drinkers had increased odds of changing consumption because of energy-related concerns, and unemployed respondents had reduced odds.Conclusions: Results indicate that some sociodemographic groups are changing alcohol consumption for energy-related reasons, but others are not, representing an underutilised opportunity for health promotion communication. Further research should investigate whether messaging to increase awareness of alcohol energy content, including through systems-based policy actions such as nutritional/energy product labelling, would motivate reduced consumption across a broader range of drinkers. [ABSTRACT FROM AUTHOR]

18. Immunogenicity of Ad26.COV2.S prime and two subsequent doses of mRNA SARS‐CoV‐2 vaccines in solid organ transplant recipients: A case series. [2022]

  • Chang, Amy, Mitchell, Jonathan, Alejo, Jennifer L., Chiang, Teresa P.Y., Abedon, Aura T, Kim, Jake D., Avery, Robin K., Tobian, Aaron A.R., Levan, Macey L., Warren, Daniel S., Garonzik‐Wang, Jacqueline M., Massie, Allan B., Segev, Dorry L., and Werbel, William A.
  • Clinical Transplantation. Sep2022, Vol. 36 Issue 9, p1-3. 3p.
Subjects
COVID-19 vaccines, TRANSPLANTATION of organs, tissues, etc., IMMUNE response, MESSENGER RNA, and SARS-CoV-2 Delta variant
Abstract
Heterologous vaccination has been explored in small populations of solid organ transplant recipients (SOTRs),1-4 yet 38% of participants had persistently suboptimal response indicating potential role for further vaccine doses.1 The US CDC currently recommends immunocompromised adults who received an Ad26.COV2.S prime to receive one additional dose of SARS-CoV-2 mRNA vaccine, either BNT162b2 or mRNA-1273, followed by two mRNA vaccine boosters, although the efficacy of this strategy in immunocompromised persons is not known. A third dose of SARS-CoV-2 vaccine increases neutralizing antibodies against variants of concern in solid organ transplant recipients. Immunogenicity of Ad26.COV2.S prime and two subsequent doses of mRNA SARS-CoV-2 vaccines in solid organ transplant recipients: A case series. [Extracted from the article]

19. Location-specific psychosocial and environmental correlates of physical activity and sedentary time in young adolescents: preliminary evidence for location-specific approaches from a cross-sectional observational study. [2022]

  • Ortega, Adrian, Bejarano, Carolina M., Cushing, Christopher C., Staggs, Vincent S., Papa, Amy E., Steel, Chelsea, Shook, Robin P., Conway, Terry L., Saelens, Brian E., Glanz, Karen, Cain, Kelli L., Frank, Lawrence D., Kerr, Jacqueline, Schipperijn, Jasper, Sallis, James F., and Carlson, Jordan A.
  • International Journal of Behavioral Nutrition & Physical Activity. 8/26/2022, Vol. 19 Issue 1, p1-17. 17p.
Subjects
SEDENTARY lifestyles, GLOBAL Positioning System, HOME environment, SCHOOL environment, BUILT environment, SOCIAL support, CROSS-sectional method, SELF-evaluation, POPULATION geography, PHYSICAL activity, SOCIAL context, ACCELEROMETRY, SELF-efficacy, QUESTIONNAIRES, DESCRIPTIVE statistics, STATISTICAL models, and ADOLESCENCE
Abstract
Background: A better understanding of the extent to which psychosocial and environmental correlates of physical activity are specific to locations would inform intervention optimization. Purpose: To investigate cross-sectional associations of location-general and location-specific variables with physical activity and sedentary time in three common locations adolescents spend time. Methods: Adolescents (N = 472,Mage = 14.1,SD = 1.5) wore an accelerometer and global positioning systems (GPS) tracker and self-reported on psychosocial (e.g., self-efficacy) and environmental (e.g., equipment) factors relevant to physical activity and sedentary time. We categorized each survey item based on whether it was specific to a location to generate psychosocial and environmental indices that were location-general or specific to either school, non-school, or home location. Physical activity (MVPA) and sedentary time were based on time/location match to home, school, or all "other" locations. Mixed-effects models investigated the relation of each index with location-specific activity. Results: The location-general and non-school physical activity psychosocial indices were related to greater MVPA at school and "other" locations. The school physical activity environment index was related to greater MVPA and less sedentary time at school. The home activity environment index was related to greater MVPA at home. The non-school sedentary psychosocial index was related to less sedentary time at home. Interactions among indices revealed adolescents with low support on one index benefited (i.e., exhibited more optimal behavior) from high support on another index (e.g., higher scores on the location-general PA psychosocial index moderated lower scores on the home PA environment index). Concurrent high support on two indices did not provide additional benefit. Conclusions: No psychosocial or environment indices, including location-general indices, were related to activity in all locations. Most of the location-specific indices were associated with activity in the matching location(s). These findings provide preliminary evidence that psychosocial and environmental correlates of activity are location specific. Future studies should further develop location-specific measures and evaluate these constructs and whether interventions may be optimized by targeting location-specific psychosocial and environmental variables across multiple locations. [ABSTRACT FROM AUTHOR]

20. Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency. [2022]

  • González, Bryan J., Zhao, Haoquan, Niu, Jacqueline, Williams, Damian J., Lee, Jaeyop, Goulbourne, Chris N., Xing, Yuan, Wang, Yong, Oberholzer, Jose, Blumenkrantz, Maria H., Chen, Xiaojuan, LeDuc, Charles A., Chung, Wendy K., Colecraft, Henry M., Gromada, Jesper, Shen, Yufeng, Goland, Robin S., Leibel, Rudolph L., and Egli, Dieter
  • Communications Biology. 8/2/2022, Vol. 5 Issue 1, p1-17. 17p.
Subjects
MATURITY onset diabetes of the young, GRANULE cells, INSULIN, STEM cells, and INTRACELLULAR calcium
Abstract
Mutations in HNF1A cause Maturity Onset Diabetes of the Young (HNF1A-MODY). To understand mechanisms of β-cell dysfunction, we generated stem cell-derived pancreatic endocrine cells with hypomorphic mutations in HNF1A. HNF1A-deficient β-cells display impaired basal and glucose stimulated-insulin secretion, reduced intracellular calcium levels in association with a reduction in CACNA1A expression, and accumulation of abnormal insulin granules in association with SYT13 down-regulation. Knockout of CACNA1A and SYT13 reproduce the relevant phenotypes. In HNF1A deficient β-cells, glibenclamide, a sulfonylurea drug used in the treatment of HNF1A-MODY patients, increases intracellular calcium, and restores insulin secretion. While insulin secretion defects are constitutive in β-cells null for HNF1A, β-cells heterozygous for hypomorphic HNF1A (R200Q) mutations lose the ability to secrete insulin gradually; this phenotype is prevented by correction of the mutation. Our studies illuminate the molecular basis for the efficacy of treatment of HNF1A-MODY with sulfonylureas, and suggest promise for the use of cell therapies. hPSCs model of Maturity Onset Diabetes of the Young caused by mutations in the transcription factor HNF1A (HNF1A-MODY), regulates the expression of genes required for the formation of dense-core insulin granules and calcium-dependent insulin secretion, demonstrating a basis to treat HNF1A-MODY patients with sulfonylureas. [ABSTRACT FROM AUTHOR]

21. Improved humoral immunogenicity with mRNA‐1273 versus BNT162b2 as third vaccine dose among solid organ transplant recipients seronegative after two BNT162b2 doses. [2022]

  • Chang, Amy, Chiang, Teresa PY., Kim, Jake D., Mitchell, Jonathan, Alejo, Jennifer L., Jefferis, Alexa A., Avery, Robin K., Tobian, Aaron A. R., Levan, Macey L., Warren, Daniel S., Garonzik‐Wang, Jacqueline M., Massie, Allan B., Segev, Dorry L., and Werbel, William A.
  • Clinical Transplantation. Aug2022, Vol. 36 Issue 8, p1-4. 4p.
Subjects
COVID-19 vaccines, TRANSPLANTATION of organs, tissues, etc., VACCINES, and IMMUNE response
Abstract
Fewer than 45% of solid organ transplant recipients (SOTRs) mount a detectable antispike antibody level after two doses of mRNA SARS-CoV-2 vaccination (D2).1 Various vaccination strategies, including mixing platforms, have been proposed, but there is no consensus on the optimal vaccination sequence to improve immunogenicity.2,3 Although using similar technology, the mRNA-1273 vaccine has been associated with higher peak antibody responses than the use of BNT162b2 in immunosuppressed populations, potentially related to a higher vaccine antigen dose.3,4 We therefore studied whether the use of mRNA-1273 versus BNT162b2 as a third primary vaccine dose (D3) might generate a more robust antibody response in SOTR who remained seronegative after two doses of BNT162b2. Improved humoral immunogenicity with mRNA-1273 versus BNT162b2 as third vaccine dose among solid organ transplant recipients seronegative after two BNT162b2 doses METHODS From our national observational study, approved by the Johns Hopkins Institutional Review Board (IRB00248540),4 we included adult SOTRs who tested seronegative after two doses of BNT162b2 and received either a D3-BNT162b2 or D3-mRNA-1273. [Extracted from the article]

22. Levels of Parental Drinking in the Presence of Children: An Exploration of Attitudinal Correlates. [2022]

  • Bowden, Jacqueline A, Delfabbro, Paul, Room, Robin, Miller, Caroline L, and Wilson, Carlene
  • Alcohol & Alcoholism. Jul2022, Vol. 57 Issue 4, p460-469. 10p.
Subjects
MOTHERS, PARENT attitudes, SOCIAL norms, AGE distribution, CROSS-sectional method, INTERNET, FATHERS, SEX distribution, PARENTING, ALCOHOL drinking, DESCRIPTIVE statistics, PARENT-child relationships, and PARENTS
Abstract
Aims This study aimed to examine perceived social norms, the effect of parental drinking on these norms, alcohol use in front of children, and how norms and consumption vary based on child age and gender of the parent. Methods A cross-sectional online panel survey was undertaken with n  = 1000 Australian adults (including 670 parents) aged 18–59 years. The survey assessed: alcohol consumption in front of children; normative attitudes towards drinking in the presence of children; and perceived social norms. Results Overall, 33.9% of parents reported drinking a glass of alcohol each day or a couple of times a week, 18.2% reported getting slightly drunk and 7.8% indicated getting visibly drunk each day or a couple of times a week with their children present. In total, 37.5% reported drinking in front of their children at least weekly. Fathers were more likely to drink in front of children than mothers. Most parents deemed drinking small amounts of alcohol in front of children as acceptable but did not accept drunkenness. Respondents were less concerned about a father drinking one or two drinks in front of their children than a mother. Social expectations were not related to child age, but norms related to others' perceived behaviour were. Conclusions Many parents, particularly fathers consume alcohol in front of their children. There is a need to target health promotion strategies to adults and parents consuming in excess of health guidelines, and to the many parents who are consuming alcohol at higher levels in front of their children. [ABSTRACT FROM AUTHOR]

23. New Directions in Feminism and Global Race Studies: A Book Conversation. [2022]

  • Florvil, Tiffany N., Glover, Kaiama L., Joseph-Gabriel, Annette K., Marino, Katherine M., Mitchell, Robin, Mogoué, Jacqueline-Bethel, and Pinto, Samantha
  • Signs: Journal of Women in Culture & Society. Summer2022, Vol. 47 Issue 4, p1013-1040. 28p.
Subjects
BLACK feminism, HISTORY of feminism, FEMINISM, BLACK feminists, WORLD history, CONVERSATION, and RACISM
Abstract
This roundtable stems from a Zoom event, "New Directions in Feminism and Global Race Studies (a Book Conversation)" with authors Tiffany N. Florvil, Kaiama L. Glover, Annette K. Joseph-Gabriel, Katherine M. Marino, Robin Mitchell, and Jacqueline-Bethel Tchouta Mougoué, hosted by Samantha Pinto. These scholars discussed their recently published books, which expand how we think about transnational feminism and global Black feminisms in the Americas, the Caribbean, Africa, and Europe. The lightly edited transcript of the conversation explores how putting Black women at the center of histories of global feminisms and race studies transforms these fields and the questions that are usually asked. The authors also discussed navigating research challenges and confronting racism in the sources and in the archives. The conversation underscores the importance of intellectual community, as well as the relevance and urgency of Black feminist scholarship today. [ABSTRACT FROM AUTHOR]

24. Combination Therapy With Casirivimab/Imdevimab and Remdesivir for Protracted SARS-CoV-2 Infection in B-cell-Depleted Patients. [2022]

  • Dioverti, M Veronica, Gaston, David C, Morris, C Paul, Huff, Carol Ann, Jain, Tania, Jones, Richard, Anders, Viki, Lederman, Howard, Saunders, Jacqueline, Mostafa, Heba H, and Avery, Robin K
  • Open Forum Infectious Diseases. Jun2022, Vol. 9 Issue 6, p1-5. 5p.
Subjects
COVID-19, SARS-CoV-2, and REMDESIVIR
Abstract
Profoundly B-cell-depleted patients can have prolonged severe acute respiratory syndrome coronavirus 2 infections with evidence of active viral replication, due to inability to mount an adequate humoral response to clear the virus. We present 3 B-cell-depleted patients with prolonged coronavirus disease 2019 infection who were successfully treated with a combination of casirivimab/imdevimab and remdesivir. [ABSTRACT FROM AUTHOR]

25. Should we "just stick to the facts"? The benefit of controversial conversations in classrooms. [2022]

  • Kraatz, Elizabeth, von Spiegel, Jacqueline, Sayers, Robin, and Brady, Anna C.
  • Theory Into Practice. Summer2022, Vol. 61 Issue 3, p312-324. 13p. 1 Chart.
Subjects
TEACHERS, TEACHING of controversial topics, STUDENTS, DISCUSSION in education, and SOCIAL conditions of students
Abstract
Controversial topics may be uncomfortable for teachers to include in their in-class discussions. However, there are considerable cognitive and social-emotional benefits to engagement in controversial conversations, or classroom discussion about controversial topics. It is critical that teachers support students in respectful discussion to help them develop skills such as problem solving, critical thinking, and the ability to consider issues from multiple perspectives. These skills can enable students to meet larger educational goals such as engaged citizenship. The goal of this article is to highlight the benefits of controversial conversations in the classroom and describe teaching approaches that facilitate effective controversial conversations. First, we identify important factors for teachers' consideration in supporting effective and beneficial controversial conversations. Second, we provide examples of topics of conversations that may be appropriate for students of varying ages. Third, we review how the structure of conversation, scaffolding, classroom context, relationships, and students' individual differences can shape controversial conversations. [ABSTRACT FROM AUTHOR]

26. A novel air microfluidics-enabled soft robotic sleeve: Toward realizing innovative lymphedema treatment. [2022]

  • Gao, Run Ze, Mai, Vivian Ngoc Tram, Levinski, Nicholas, Kormylo, Jacqueline Mary, Murdock, Robin Ward, Dickerson, Clark R., and Ren, Carolyn L.
  • Biomicrofluidics. May2022, Vol. 16 Issue 3, p1-11. 11p.
Subjects
SOFT robotics, LYMPHEDEMA, SLEEVES, AIR pressure, MICROFLUIDICS, VALVES, MICROFLUIDIC devices, and DRAINAGE
Abstract
A proof of concept of a novel air microfluidics-enabled soft robotic sleeve to enable lymphedema treatment is presented. Compression sleeves represent the current, suboptimal standard of care, and stationary pumps assist with lymph drainage; however, effective systems that are truly wearable while performing daily activities are very scarce. This problematic trade-off between performance and wearability requires a new solution, which is addressed by an innovative microfluidic device. Its novelty lies in the use of light, small, and inexpensive air microfluidic chips (35 × 20 × 5 mm3 in size) that bring three major advantages compared to their traditional counterparts. First, each chip is designed with 16 fluidic channels with a cross-sectional area varying from 0.04 to 1 mm2, providing sequential inflation and uniform deflation capability to eight air bladders, thereby producing intentional gradient compression to the arm to facilitate lymph fluid circulation. The design is derived from the fundamentals of microfluidics, in particular, hydraulic resistance and paths of least resistance. Second, the air microfluidic chip enables miniaturization of at least eight bulky energy-consuming valves to two miniature solenoid valves for control increasing wearability. Third, the air microfluidic chip has no moving parts, which reduces the noise and energy needed. The cost, simplicity, and scale-up potential of developing methods for making the system are also detailed. The sequential inflation, uniform deflation, and pressure gradient are demonstrated, and the resulted compression and internal air bladder pressure were evaluated. This air microfluidics-enabled sleeve presents tremendous potential toward future improvements in self-care lymphedema management. [ABSTRACT FROM AUTHOR]

27. Infectious diseases, comorbidities and outcomes in hospitalized people who inject drugs (PWID) infections in persons who inject drugs. [2022]

  • Lim, Jacqueline, Pavalagantharajah, Sureka, Verschoor, Chris P, Lentz, Eric, Loeb, Mark, Levine, Mitchell, Smieja, Marek, Mbuagbaw, Lawrence, Kalina, Dale, Tarride, Jean-Eric, O'Shea, Tim, Cvetkovic, Anna, van Gaalen, Sarah, Findlater, Aidan Reid, Lennox, Robin, Bassim, Carol, Lokker, Cynthia, and Alvarez, Elizabeth
  • PLoS ONE. 4/20/2022, Vol. 17 Issue 4, p1-12. 12p.
Subjects
COMMUNICABLE diseases, INFECTIOUS arthritis, HOSPITAL patients, CELLULITIS, DRUG abuse, DRUGS, and FISHER exact test
Abstract
Injection drug use poses a public health challenge. Clinical experience indicates that people who inject drugs (PWID) are hospitalized frequently for infectious diseases, but little is known about outcomes when admitted. Charts were identified from local hospitals between 2013–2018 using consultation lists and hospital record searches. Included individuals injected drugs in the past six months and presented with infection. Charts were accessed using the hospital information system, undergoing primary and secondary reviews using Research Electronic Data Capture (REDCap). The Wilcoxon rank-sum test was used for comparisons between outcome categories. Categorical data were summarized as count and frequency, and compared using Fisher's exact test. Of 240 individuals, 33% were admitted to the intensive care unit, 36% underwent surgery, 12% left against medical advice (AMA), and 9% died. Infectious diagnoses included bacteremia (31%), abscess (29%), endocarditis (29%), cellulitis (20%), sepsis (10%), osteomyelitis (9%), septic arthritis (8%), pneumonia (7%), discitis (2%), meningitis/encephalitis (2%), or other (7%). Sixty-six percent had stable housing and 60% had a family physician. Fifty-four percent of patient-initiated discharges were seen in the emergency department within 30 days and 29% were readmitted. PWID are at risk for infections. Understanding their healthcare trajectory is essential to improve their care. [ABSTRACT FROM AUTHOR]

28. High Levels of Sedentary Time in Patients with COVID-19 after Hospitalisation. [2022]

  • van Bakel, Bram M. A., van den Heuvel, Frederik M. A., Vos, Jacqueline L., Rotbi, Hajar, Bakker, Esmée A., Nijveldt, Robin, Thijssen, Dick H. J., and Eijsvogels, Thijs M. H.
  • Journal of Clinical Medicine. Feb2022, Vol. 11 Issue 4, pN.PAG-N.PAG. 1p.
Subjects
COVID-19, SEDENTARY behavior, PHYSICAL activity, HOSPITAL care, and PATIENTS' attitudes
Abstract
Many patients with COVID-19 experience severe and even fatal disease. Survivors may have long-term health consequences, but data on physical activity and sedentary behaviour are scarce. Therefore, we objectively assessed physical activity (PA) patterns among post-hospitalised patients with COVID-19 and explored associations with patient characteristics, disease severity and cardiac dysfunction. We objectively assessed PA, sedentary behaviour and sleep duration for 24 h/day during 8 days at 3-6 months after COVID-19 hospitalisation. PA and sedentary time were compared across pre-defined subgroups based on patient and disease characteristics, cardiac biomarker release during hospitalisation, abnormal transthoracic echocardiogram at 3-6 months post-hospitalisation and persistence of symptoms post-discharge. PA and sedentary behaviour were assessed in 37 patients (60 ± 10 years old; 78% male). Patients spent 4.2 [3.2; 5.3] h/day light-intensity PA and 1.0 [0.8; 1.4] h/day moderate-to-vigorous intensity PA. Time spent sitting was 9.8 [8.7; 11.2] h/day, which was accumulated in 6 [5; 7] prolonged sitting bouts (≥30 min) and 41 [32; 48] short sitting bouts (<30 min). No differences in PA and sedentary behaviour were found across subgroups, but sleep duration was higher in patients with versus without persistent symptoms (9.1 vs. 8.3 h/day, p = 0.02). Taken together, high levels of sedentary time are common at 3–6 months after COVID-19 hospitalisation, whilst PA and sedentary behaviour are not impacted by patient or disease characteristics. [ABSTRACT FROM AUTHOR]

29. Advancing social inclusion of people with disabilities through awareness and training activities: A collaborative process between community partners and researchers. [2022]

  • Rochette, Annie, Roberge-Dao, Jacqueline, Roche, Lise, Kehayia, Eva, Ménard, Lyne, Robin, Jean-Pierre, Sauvé, Méric, Shikako-Thomas, Keiko, St-Onge, Marc, Swaine, Bonnie, Thomas, Aliki, Vallée-Dumas, Catherine, and Fougeyrollas, Patrick
  • Patient Education & Counseling. Feb2022, Vol. 105 Issue 2, p416-425. 10p.
Subjects
DISABILITY awareness, PEOPLE with disabilities, CRITICAL thinking, RESEARCH personnel, and STRATEGIC planning
Abstract
Objective: The main objectives were to 1) search and map current disability awareness and training activities in Quebec, Canada, 2) collectively reflect on these practices, and 3) develop a five-year strategic plan.Methods: We used an integrated knowledge translation approach whereby researchers and community partners were involved in all stages. This project consisted of two sequential phases: 1) an environmental scan (web review and interview) of current practices, and 2) a reflection process with an external expert-facilitator in social transformation. Outcome results and process data are reported.Results: We identified 129 activities (71 training, 58 awareness) from 39 organizations (from 123 organizations initially invited). A wide range of characteristics were collected for each activity which allowed for the identification of gaps. The working group met seven times in one year to discuss results from phase 1 and co-create a five-year strategic plan. Main priorities are 1) the development of a methodology for measuring collective impact and 2) content synchronization of activities.Conclusion: Involvement of partners and researchers enabled a concerted and efficient approach to the development of a five-year strategic plan.Practice Implications: A transition committee led by partners will ensure implementation and sustainability of the plan across the province. [ABSTRACT FROM AUTHOR]

30. PART is part of SNAP‐MCI [2022]

  • Wisse, Laura EM, Xie, Long, Lyu, Xueying, Das, Sandhitsu R., de Flores, Robin, Lane, Jacqueline, Yushkevich, Paul A., Wolk, David A., and Initiative, Disease Neuroimaging
  • Alzheimer's & dementia. 18(6)

31. Drug therapy, imaging, and other aspects of clinical management change after Alzheimer's biomarker testing in routine practice: Findings from the IMPACT‐AD BC study [2022]

  • Yang, David, Best, John R., Chambers, Colleen, Feldman, Howard H., Pettersen, Jacqueline A, Henri‐Bhargava, Alexander, Lee, Philip E, Nygaard, Haakon B., Funnell, Clark R, Foti, Dean J, Hsiung, Ging‐Yuek Robin, and DeMarco, Mari L.
  • Alzheimer's & dementia. 18(6)

32. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids [2022]

  • Ramdas, Shweta, Judd, Jonathan, Graham, Sarah E., Kanoni, Stavroula, Wang, Yuxuan, Surakka, Ida, Wenz, Brandon, Clarke, Shoa L., Chesi, Alessandra, Wells, Andrew, Bhatti, Konain Fatima, Vedantam, Sailaja, Winkler, Thomas W., Locke, Adam E., Marouli, Eirini, Zajac, Greg J.M., Wu, Kuan-Han H., Ntalla, Ioanna, Hui, Qin, Klarin, Derek, Hilliard, Austin T., Wang, Zeyuan, Xue, Chao, Thorleifsson, Gudmar, Helgadottir, Anna, Gudbjartsson, Daniel F., Holm, Hilma, Olafsson, Isleifur, Hwang, Mi Yeong, Han, Sohee, Akiyama, Masato, Sakaue, Saori, Terao, Chikashi, Kanai, Masahiro, Zhou, Wei, Brumpton, Ben M., Rasheed, Humaira, Havulinna, Aki S., Veturi, Yogasudha, Pacheco, Jennifer Allen, Rosenthal, Elisabeth A., Lingren, Todd, Feng, QiPing, Kullo, Iftikhar J., Narita, Akira, Takayama, Jun, Martin, Hilary C., Hunt, Karen A., Trivedi, Bhavi, Haessler, Jeffrey, Giulianini, Franco, Bradford, Yuki, Miller, Jason E., Campbell, Archie, Lin, Kuang, Millwood, Iona Y., Rasheed, Asif, Hindy, George, Faul, Jessica D., Zhao, Wei, Weir, David R., Turman, Constance, Huang, Hongyan, Graff, Mariaelisa, Choudhury, Ananyo, Sengupta, Dhriti, Mahajan, Anubha, Brown, Michael R., Zhang, Weihua, Yu, Ketian, Schmidt, Ellen M., Pandit, Anita, Gustafsson, Stefan, Yin, Xianyong, Luan, Jian'an, Zhao, Jing-Hua, Matsuda, Fumihiko, Jang, Hye-Mi, Yoon, Kyungheon, Medina-Gomez, Carolina, Pitsillides, Achilleas, Hottenga, Jouke Jan, Wood, Andrew R., Ji, Yingji, Gao, Zishan, Haworth, Simon, Mitchell, Ruth E., Chai, Jin Fang, Aadahl, Mette, Bjerregaard, Anne A., Yao, Jie, Manichaikul, Ani, Lee, Wen-Jane, Hsiung, Chao Agnes, Warren, Helen R., Ramirez, Julia, Bork-Jensen, Jette, Kårhus, Line L., Goel, Anuj, Sabater-Lleal, Maria, Noordam, Raymond, Mauro, Pala, Matteo, Floris, McDaid, Aaron F., Marques-Vidal, Pedro, Wielscher, Matthias, Trompet, Stella, Sattar, Naveed, Møllehave, Line T., Munz, Matthias, Zeng, Lingyao, Huang, Jianfeng, Yang, Bin, Poveda, Alaitz, Kurbasic, Azra, Schönherr, Sebastian, Forer, Lukas, Scholz, Markus, Galesloot, Tessel E., Bradfield, Jonathan P., Ruotsalainen, Sanni E., Daw, E. Warwick, Zmuda, Joseph M., Mitchell, Jonathan S., Fuchsberger, Christian, Christensen, Henry, Brody, Jennifer A., Le, Phuong, Feitosa, Mary F., Wojczynski, Mary K., Hemerich, Daiane, Preuss, Michael, Mangino, Massimo, Christofidou, Paraskevi, Verweij, Niek, Benjamins, Jan W., Engmann, Jorgen, Noah, Tsao L., Verma, Anurag, Slieker, Roderick C., Lo, Ken Sin, Zilhao, Nuno R., Kleber, Marcus E., Delgado, Graciela E., Huo, Shaofeng, Ikeda, Daisuke D., Iha, Hiroyuki, Yang, Jian, Liu, Jun, Demirkan, Ayşe, Leonard, Hampton L., Marten, Jonathan, Emmel, Carina, Schmidt, Börge, Smyth, Laura J., Cañadas-Garre, Marisa, Wang, Chaolong, Nakatochi, Masahiro, Wong, Andrew, Hutri-Kähönen, Nina, Sim, Xueling, Xia, Rui, Huerta-Chagoya, Alicia, Fernandez-Lopez, Juan Carlos, Lyssenko, Valeriya, Nongmaithem, Suraj S., Sankareswaran, Alagu, Irvin, Marguerite R., Oldmeadow, Christopher, Kim, Han-Na, Ryu, Seungho, Timmers, Paul R.H.J., Arbeeva, Liubov, Dorajoo, Rajkumar, Lange, Leslie A., Prasad, Gauri, Lorés-Motta, Laura, Pauper, Marc, Long, Jirong, Li, Xiaohui, Theusch, Elizabeth, Takeuchi, Fumihiko, Spracklen, Cassandra N., Loukola, Anu, Bollepalli, Sailalitha, Warner, Sophie C., Wang, Ya Xing, Wei, Wen B., Nutile, Teresa, Ruggiero, Daniela, Sung, Yun Ju, Chen, Shufeng, Liu, Fangchao, Yang, Jingyun, Kentistou, Katherine A., Banas, Bernhard, Morgan, Anna, Meidtner, Karina, Bielak, Lawrence F., Smith, Jennifer A., Hebbar, Prashantha, Farmaki, Aliki-Eleni, Hofer, Edith, Lin, Maoxuan, Concas, Maria Pina, Vaccargiu, Simona, van der Most, Peter J., Pitkänen, Niina, Cade, Brian E., van der Laan, Sander W., Chitrala, Kumaraswamy Naidu, Weiss, Stefan, Bentley, Amy R., Doumatey, Ayo P., Adeyemo, Adebowale A., Lee, Jong Young, Petersen, Eva R.B., Nielsen, Aneta A., Choi, Hyeok Sun, Nethander, Maria, Freitag-Wolf, Sandra, Southam, Lorraine, Rayner, Nigel W., Wang, Carol A., Lin, Shih-Yi, Wang, Jun-Sing, Couture, Christian, Lyytikäinen, Leo-Pekka, Nikus, Kjell, Cuellar-Partida, Gabriel, Vestergaard, Henrik, Hidalgo, Bertha, Giannakopoulou, Olga, Cai, Qiuyin, Obura, Morgan O., van Setten, Jessica, He, Karen Y., Tang, Hua, Terzikhan, Natalie, Shin, Jae Hun, Jackson, Rebecca D., Reiner, Alexander P., Martin, Lisa Warsinger, Chen, Zhengming, Li, Liming, Kawaguchi, Takahisa, Thiery, Joachim, Bis, Joshua C., Launer, Lenore J., Li, Huaixing, Nalls, Mike A., Raitakari, Olli T., Ichihara, Sahoko, Wild, Sarah H., Nelson, Christopher P., Campbell, Harry, Jäger, Susanne, Nabika, Toru, Al-Mulla, Fahd, Niinikoski, Harri, Braund, Peter S., Kolcic, Ivana, Kovacs, Peter, Giardoglou, Tota, Katsuya, Tomohiro, de Kleijn, Dominique, de Borst, Gert J., Kim, Eung Kweon, Adams, Hieab H.H., Ikram, M. 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Geoffrey, Ritchie, Marylyn D., Jousilahti, Pekka, Salomaa, Veikko, Hveem, Kristian, Åsvold, Bjørn Olav, Kubo, Michiaki, Kamatani, Yoichiro, Okada, Yukinori, Murakami, Yoshinori, Kim, Bong-Jo, Thorsteinsdottir, Unnur, Stefansson, Kari, Zhang, Jifeng, Chen, Y. Eugene, Ho, Yuk-Lam, Lynch, Julie A., Tsao, Philip S., Chang, Kyong-Mi, Cho, Kelly, O'Donnell, Christopher J., Gaziano, John M., Wilson, Peter, Mohlke, Karen L., Frayling, Timothy M., Hirschhorn, Joel N., Kathiresan, Sekar, Boehnke, Michael, Natarajan, Pradeep, Sun, Yan V., Morris, Andrew P., Deloukas, Panos, Peloso, Gina, Assimes, Themistocles L., Willer, Cristen J., Zhu, Xiang, and Brown, Christopher D.
  • American journal of human genetics. 109(8):1366-1387

33. Virtual Ontogeny of Cortical Growth Preceding Mental Illness [2022]

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  • Biological psychiatry. 92(4):299-313

34. Potential missed opportunities for antenatal corticosteroid exposure and outcomes among periviable births: Observational cohort study [2022]

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Michael, Goldberg, Ronald N., Finkle, Joanne, Auten, Kathy J., Fisher, Kimberley A., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Kicklighter, Stephen D., Rhodes‐Ryan, Ginger, White, Donna, Patel, Ravi M., Carlton, David P., Stoll, Barbara J., Hale, Ellen C., Loggins, Yvonne, Bottcher, Diane I., Mackie, Colleen, Bremer, Andrew A., Higgins, Rosemary D., Archer, Stephanie Wilson, Sokol, Gregory M., Herron, Dianne E., Joyce, Jeff, Miller, Lucy, Wilson, Leslie Dawn, Tyson, Jon E., Khan, Amir M., Kennedy, Kathleen A., Eason, Elizabeth, Stephens, Emily K., McDavid, Georgia E., Arldt‐McAlister, Julie, Burson, Katrina, Garcia, Carmen, Hall, Donna, Harris, Beverly Foley, Lis, Anna E., Martin, Karen, Martin, Sara C., Rodgers, Shawna, Simmons, Maegan C., Pierce Tate, Patti L., Sanchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Baugher, Hallie, Clark, Erna, Fortney, Christine A., Gutentag, Julie, Park, Courtney, Shadd, Julie C., Stein, Melanie, Grothause, Jennifer L., McCool, Jacqueline, Parikh, Nehal A., Yosseff‐Salameh, Lina, Gantz, Marie G., Bann, Carla M., Wallace, Dennis, Crawford, Margaret M., Gabrio, Jenna, Leblond, David, O'Donnell Auman, Jeanette, Petrie Huitema, Carolyn M., Zaterka‐Baxter, Kristin M., Chock, Valerie Y., Stevenson, David K., Ball, M. 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Michael, Peters, Nancy, Shankaran, Seetha, Natarajan, Girija, Chawla, Sanjay, Sood, Beena G., Pappas, Athina, Barks, John, Bara, Rebecca, Childs, Kirsten, Christensen, Mary, Panaitescu, Bogdan, Wiggins, Stephanie A., White, Diane, Ehrenkranz, Richard A., Jacobs, Harris, Cervone, Patricia, Konstantino, Monica, Poulsen, Jo Ann, and Taft, Janet
  • BJOG. 129(12):2039-2051

35. Impact of the COVID‐19 pandemic on people with epilepsy: Findings from the US arm of the COV‐E study [2022]

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  • Epilepsia open. 7(4):645-656

36. Letter to the editor: Six‐month antibody kinetics and durability in liver transplant recipients after two doses of SARS‐CoV‐2 mRNA vaccination [2022]

  • Chang, Amy, Strauss, Alexandra T., Alejo, Jennifer L., Chiang, Teresa P.‐Y., Hernandez, Nicole F., Zeiser, Laura B., Boyarsky, Brian J., Avery, Robin K., Tobian, Aaron A. R., Levan, Macey L., Warren, Daniel S., Garonzik‐Wang, Jacqueline M., Massie, Allan B., Werbel, William A., and Segev, Dorry L.
  • Hepatology communications. 6(10):2990-2992

37. Left Atrial Strain Has Superior Prognostic Value to Ventricular Function and Delayed-Enhancement in Dilated Cardiomyopathy [2022]

  • Raafs, Anne G., Vos, Jacqueline L., Henkens, Michiel T.H.M., Slurink, Bram O., Verdonschot, Job A.J., Bossers, Daan, Roes, Kit, Gerretsen, Suzanne, Knackstedt, Christian, Hazebroek, Mark R., Nijveldt, Robin, and Heymans, Stephane R.B.
  • JACC.Cardiovascular imaging. 15(6):1015-1026

38. Reply [2022]

  • Raafs, Anne G., Henkens, Michiel T.H.M., Vos, Jacqueline L., Nijveldt, Robin, and Verdonschot, Job A.J.
  • JACC.Cardiovascular imaging. 15(12):2156-2157

39. A point prevalence study of palliative care need and referral rates in adult inpatients [2022]

  • Cooper, Alannah L., Mazzer, Jacqueline, Martin‐Robins, Dipna, and Brown, Janie A.
  • Journal of clinical nursing. 31(21-22):3144-3154

40. Severe acute respiratory syndrome coronavirus 2 antibody response to a third dose of homologous messenger RNA vaccination in liver transplantation recipients [2022]

  • Strauss, Alexandra T., Chang, Amy, Alejo, Jennifer L., Chiang, Teresa P.‐Y., Hernandez, Nicole F., Zeiser, Laura B., Boyarsky, Brian J., Avery, Robin K., Tobian, Aaron A. R., Levan, Macey L., Warren, Daniel S., Massie, Allan B., Garonzik‐Wang, Jacqueline M., Segev, Dorry L., and Werbel, William A.
  • Liver transplantation. 28(8):1393-1396

41. Claims-Based Relapse and Hospitalization Rates in Patients with Multiple Sclerosis Treated with Natalizumab or Ocrelizumab [2022]

  • Nicholas, Jacqueline, Belviso, Nick, Banerjee, Geentanjoli, Geremakis, Caroline, Avila, Robin, and Bodhinathan, Karthik
  • Multiple sclerosis and related disorders. 59

42. Does coexisting accommodative dysfunction impact clinical convergence measures, symptoms and treatment success for symptomatic convergence insufficiency in children? [2022]

  • Kulp, Marjean T, Sinnott, Loraine T, Cotter, Susan A, Borsting, Eric, Toole, Andrew J, Chen, Angela M, Jenewein, Erin C, Morrison, Ann M, Plaumann, Maureen D, Jones‐Jordan, Lisa, Mitchell, G Lynn, Tea, Yin C, Scheiman, Mitchell M, Cooper, Jeffrey, Schulman, Erica, Hamian, Kimberly, Iacono, Danielle, Larson, Steven, Leung, Valerie, Meeder, Sara, Ramos, Elaine, Ritter, Steven, Steiner, Audra, Stormann, Alexandria, Vricella, Marilyn, Zhu, Xiaoying, Tamkins, Susanna, Aguilera, Naomi, Brafman, Elliot, Capo, Hilda, Cavuoto, Kara, Crespo, Isaura, Dowling, Monica, Draskovic, Kristie, Farag, Miriam, Fischer, Vicky, Grace, Sara, Gutierrez, Ailen, Manchola‐Orozco, Carolina, Martinez, Maria, McKeown, Craig, Osigian, Carla, Pham, Tuyet‐Suong, Small, Leslie, Townsend, Natalie, Gallaway, Michael, Boas, Mark, Calvert, Christine, Franz, Tara, Gerrouge, Amanda, Hayden, Donna, Margolies, Zachary, Meiyeppen, Shivakhaami, Myung, Jenny, Pollack, Karen, Shoge, Ruth, Tang, Andrew, Tannen, Noah, Trieu, Lynn, Trujillo, Luis, Buckland, Michelle, Ellis, Allison, Fogt, Jennifer, McDaniel, Catherine, McGann, Taylor, Mulvihill, Shane, Peiffer, Adam, Pierce, Gil, Preston, Julie, Reuter, Kathleen, Stevens, Nancy, Teeny, Jake, Widmer, Douglas, Zimmerman, Aaron, Barnhardt, Carmen, Chu, Raymond, Huang, Kristine, Parker, Susan, Retnasothie, Dashaini, Wu, Judith, Hertle, Richard, Clark, Penny, Culp, Kelly, Fraley, Kathy, Grant, Drusilla, Hanna, Nancy, Knox, Stephanie, Lawhon, William, Li, Lan, Mitcheff, Sarah, Ricker, Isabel, Roberts, Tawna, Solis, Casandra, Wall, Palak, Zaczyk, Samantha, Hopkins, Kristine, Marsh‐Tootle, Wendy, Bowen, Michelle, Call, Terri, Domnanovich, Kristy, Frazier, Marcela, Guyette, Nicole, Hayes, Oakley, Houser, John, Lee, Sarah, Montejo, Jenifer, Oechslin, Tamara, Spain, Christian, Turner, Candace, Weise, Katherine, Coulter, Rachel, Amster, Deborah, Bade, Annette, Bansal, Surbhi, Falco, Laura, Fecho, Gregory, Green, Katherine, Irizarry, Gabriela, Jhajj, Jasleen, Patterson, Nicole, Rodena, Jacqueline, Tyler, Julie, Weiss, Dana, Zakaib, Lauren, Lorenzana, Ingryd, Meza, Yesena, Mann, Ryan, Quezada, Mariana, Rein, Scott, Rudaitis, Indre, Stepleton, Susan, Wajs, Beata, Redford, Maryann, Denton, Carolyn, Arnold, Eugene, Chase, Christopher, Wee, Sharyl, Dahl‐Leonard, Katlynn, Powers, Kenneth, Alaniz, Amber, Diener‐West, Marie, Good, William V, Grisham, David, Kratochvil, Christopher J, Revicki, Dennis, Wanzek, Jeanne, Alrahem, Mustafa, Dangelo, Julianne, Hegedus, Jordan, Jones, Ian, Junglas, Alexander, Lee, Jihyun, Nettles, Jadin, Mitchell, Curtis, Osman, Mawada, Scott‐Tibbs, Gloria, Teasley, Chloe, Vang, Victor, Varghese, Robin, Dunbar, Mark, Moshfeghi, Arlanna, Nelson, Kathryn, Perlman, Adam, Singh, Ronda, Olivares, Eva, Rosa, Ana, Rosado, Nidia, Silverman, Elias, Brunelli, Marta, Friedman, Stacy, Zhu, Lily, Wong, Lyndon, Chung, Ida, Colon, Kaity, Sims, Janene, Swanson, Marsha, Broadfoot, Adrienne, Anderson, Michelle, Baldwin, Catherine, Mahaphon, Tanya, Bartuccio, Mary, Scombordi, Brandy, Yamada, Tomohiko, Langan, Ryan, Earley, Michael, Gabriel, Gina, Biddle, Molly, Rouse, Michael, Bridgeford, Rebecca, Morris, Jamie, Villalobos, Javier, Granet, David, Hustana, Lara, Robbins, Shira, Castro, Erica, Gomi, Cintia, Mohney, Brian G, Holmes, Jonathan, Rice, Melissa, Karlsson, Virginia, Nielsen, Becky, Sease, Jan, Shevlin, Tracee, Kitts, Tracy, Bacher, Melanie, Barrett, Linda, Watson, Kelly, Wessel, Pam, Costello, Andrew, Hays, Ron D, Hillis, Argye, and Manny, Ruth
  • Ophthalmic and physiological optics. 42(1):59-70

43. Dental management of a pediatric patient with Kohlschutter‐Tonz syndrome: A case report [2022]

  • Kulkarni, Roopali, Caster, Jacqueline M., Robin, Alec, Hajishengallis, Evlambia, Stoopler, Eric T., and Tanaka, Takako I.
  • Special care in dentistry. 42(3):308-311

44. SARS-CoV-2 messenger RNA vaccine antibody response and reactogenicity in heart and lung transplant recipients. [2021]

  • Hallett, Andrew M., Greenberg, Ross S., Boyarsky, Brian J., Shah, Pali D., Ou, Michael T., Teles, Aura T., Krach, Michelle R., López, Julia I., Werbel, William A., Avery, Robin K., Bae, Sunjae, Tobian, Aaron A., Massie, Allan B., Higgins, Robert S.D., Garonzik-Wang, Jacqueline M., Segev, Dorry L., and Bush, Errol L.
  • Journal of Heart & Lung Transplantation. Dec2021, Vol. 40 Issue 12, p1579-1588. 10p.
Subjects
ANTIBODY formation, VACCINE effectiveness, HEART transplant recipients, SARS-CoV-2, and MESSENGER RNA
Abstract
While several studies have observed that solid organ transplant recipients experience diminished antibody responses to SARS-CoV-2 mRNA vaccination, data specific to heart and lung transplant (HT/LT) recipients remains sparse. US adult HT and LT recipients completed their vaccine series between January 7 and April 10, 2021. Reactogencity and SARS-CoV-2 anti-spike antibody were assessed after a priming dose (D1) and booster dose (D2). Modified Poisson regression with robust variance estimator was used to evaluate associations between participant characteristics and antibody development. Of 134 heart recipients, there were 38% non-responders (D1-/D2-), 48% booster responders (D1-/D2+), and 14% priming dose responders (D1+/D2+). Of 103 lung recipients, 64% were non-responders, 27% were booster responders, and 9% were priming dose responders. Lung recipients were less likely to develop antibodies (p <.001). Priming dose antibody response was associated with younger recipient age (p =.04), transplant-to-vaccination time ≥6 years (p <.01), and lack of anti-metabolite maintenance immunosuppression (p <.001). Pain at injection site was the most commonly reported reaction (85% after D1, 76% after D2). Serious reactions were rare, the most common being fatigue (2% after D1 and 3% after D2). No serious adverse events were reported. HT and LT recipients experienced diminished antibody response following vaccination; reactogenicity was comparable to that of the general population. LT recipients may exhibit a more impaired antibody response than HT recipients. While current recommendations are to vaccinate eligible candidates and recipients, further studies characterizing the cell-mediated immune response and clinical efficacy of these vaccines in this population are needed. [ABSTRACT FROM AUTHOR]

45. Observation, practice, and purpose: Recalibrating curriculum to enhance professional development. [2021]

  • Schwab, Jacqueline E., Murowchick, Elise, Yaure, Robin G., and Cruz, Laura
  • New Directions for Teaching & Learning. Winter2021, Vol. 2021 Issue 168, p59-68. 10p.
Subjects
PROFESSIONAL education, IDENTITY (Psychology), PROFESSIONAL identity, INTERPERSONAL conflict, CONFLICT management, and CURRICULUM
Abstract
This article describes the development and assessment of teaching strategies to enhance student professional identity development by shifting the pedagogical focus from content knowledge to the practice of interpersonal and conflict resolution skills, and reflection to create awareness, observe growth, and find meaning. [ABSTRACT FROM AUTHOR]

46. Why we need sex- and gender-based analyses in rehabilitation research now. [2021]

  • Quigley, Adria, McArthur, Caitlin, Parker, Robin, and Gahagan, Jacqueline
  • Annals of Physical & Rehabilitation Medicine. Nov2021, Vol. 64 Issue 6, pN.PAG-N.PAG. 1p.
Subjects
GENDER mainstreaming and REHABILITATION

47. Differential Effects of Film Genre on Viewers' Absorption, Identification, and Enjoyment. [2021]

  • Thompson, Jacqueline M., Teasdale, Ben, Duncan, Sophie, van Emde Boas, Evert, Budelmann, Felix, Maguire, Laurie, and Dunbar, Robin I. M.
  • Psychology of Aesthetics, Creativity & the Arts. Nov2021, Vol. 15 Issue 4, p697-709. 13p.
Abstract
Marketers, filmmakers, and cinema-goers assume that genre has a large effect on how the audience responds to and engages with a film. However, trait measures such as transportability suggest that, in some cases, individual differences may shape audience engagement more than genre does. To investigate this disparity, we compared viewers' enjoyment, identification with characters, and story world absorption (including three subscales: Transportation, Attention, and Emotional Engagement) for film clips from two very different genres (an emotional family film vs. an action chase scene) in a within-subjects design. Across two studies--an exploratory study and a preregistered replication--we found that participants' feelings of being transported into the narrative (a dimension of story world absorption) were more highly correlated across films than other measures were and tended to be less related to genre preference than the other audience response measures were. This pattern of results suggests that feelings of transportation may be more dependent on individual differences, and less sensitive to genre, than other forms of audience response. An exploratory analysis of a short scale measuring trait transportability suggested this measure was not the basis of the individual differences theorized to underlie transportation. Our results further highlight the importance of examining viewer engagement with narrative as a multidimensional, rather than unitary, concept. [ABSTRACT FROM AUTHOR]

48. Impact of the COVID-19 pandemic on people with epilepsy: Findings from the Brazilian arm of the COV-E study. [2021]

  • Andraus, Maria, Thorpe, Jennifer, Tai, Xin You, Ashby, Samantha, Hallab, Asma, Ding, Ding, Dugan, Patricia, Perucca, Piero, Costello, Daniel, French, Jacqueline A., O'Brien, Terence J., Depondt, Chantal, Andrade, Danielle M., Sengupta, Robin, Delanty, Norman, Jette, Nathalie, Newton, Charles R., Brodie, Martin J., Devinsky, Orrin, and Helen Cross, J.
  • Epilepsy & Behavior. Oct2021, Vol. 123, pN.PAG-N.PAG. 1p.
Subjects
COVID-19 pandemic, MEDICAL personnel, PEOPLE with epilepsy, SOCIAL distancing, and CAREGIVER attitudes
Abstract
• The COVID-19 and Epilepsy (COV-E) global surveys were launched in Brazil during the first wave of the pandemic. • People with epilepsy reported worsening seizure control, psychosocial stress, and impaired mental health. • There were difficulties in obtaining drug supplies because of canceled appointments. • Discussion of risk, including SUDEP, was infrequent even before the pandemic. • The surveys remain open to enable new participants to enter data providing insights as the pandemic evolves. The COVID-19 pandemic has had an unprecedented impact on people and healthcare services. The disruption to chronic illnesses, such as epilepsy, may relate to several factors ranging from direct infection to secondary effects from healthcare reorganization and social distancing measures. As part of the COVID-19 and Epilepsy (COV-E) global study, we ascertained the effects of COVID-19 on people with epilepsy in Brazil, based on their perspectives and those of their caregivers. We also evaluated the impact of COVID-19 on the care delivered to people with epilepsy by healthcare workers. We designed separate online surveys for people with epilepsy and their caregivers. A further survey for healthcare workers contained additional assessments of changes to working patterns, productivity, and concerns for those with epilepsy under their care. The Brazilian arm of COV-E initially collected data from May to November 2020 during the country's first wave. We also examined national data to identify the Brazilian states with the highest COVID-19 incidence and related mortality. Lastly, we applied this geographic grouping to our data to explore whether local disease burden played a direct role in difficulties faced by people with epilepsy. Two hundred and forty-one people returned the survey, 20% were individuals with epilepsy (n = 48); 22% were caregivers (n = 53), and 58% were healthcare workers (n = 140). Just under half (43%) of people with epilepsy reported health changes during the pandemic, including worsening seizure control, with specific issues related to stress and impaired mental health. Of respondents prescribed antiseizure medication, 11% reported difficulty taking medication on time due to problems acquiring prescriptions and delayed or canceled medical appointments. Only a small proportion of respondents reported discussing significant epilepsy-related risks in the previous 12 months. Analysis of national COVID-19 data showed a higher disease burden in the states of Sao Paulo and Rio de Janeiro compared to Brazil as a whole. There were, however, no geographic differences observed in survey responses despite variability in the incidence of COVID-19. Our findings suggest that Brazilians with epilepsy have been adversely affected by COVID-19 by factors beyond infection or mortality. Mental health issues and the importance of optimal communication are critical during these difficult times. Healthcare services need to find nuanced approaches and learn from shared international experiences to provide optimal care for people with epilepsy as the direct burden of COVID-19 improves in some countries. In contrast, others face resurgent waves of the pandemic. [ABSTRACT FROM AUTHOR]

49. TU54. GENETIC VARIATION IN THE 5-HTTLPR AND REWARD PROCESSING: A NEUROIMAGING GENETICS STUDY. [2021]

  • Swart, Patricia, Womersley, Jacqueline S., van den Heuvel, Leigh, Hemmings, Sian, Emsley, Robin, Carr, Jonathan, Seedat, Soraya, and Pleiss, Stefan Du
  • European Neuropsychopharmacology. Oct2021, Vol. 51, pe124-e124. 1p.
Subjects
GENETIC variation, REWARD (Psychology), and BRAIN imaging

50. Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis. [2021]

  • Anderson, Emma L, Richmond, Rebecca C, Jones, Samuel E, Hemani, Gibran, Wade, Kaitlin H, Dashti, Hassan S, Lane, Jacqueline M, Wang, Heming, Saxena, Richa, Brumpton, Ben, Korologou-Linden, Roxanna, Nielsen, Jonas B, Åsvold, Bjørn Olav, Abecasis, Gonçalo, Coulthard, Elizabeth, Kyle, Simon D, Beaumont, Robin N, Tyrrell, Jessica, Frayling, Timothy M, and Munafò, Marcus R
  • International Journal of Epidemiology. Jun2021, Vol. 50 Issue 3, p817-828. 12p.
Subjects
DROWSINESS, ALZHEIMER'S disease, GENOME-wide association studies, SLEEP, RESEARCH, SEQUENCE analysis, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, and RESEARCH funding
Abstract
Background: It is established that Alzheimer's disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset of AD.Methods: We used the largest published genome-wide association studies of self-reported and accelerometer-measured sleep traits (chronotype, duration, fragmentation, insomnia, daytime napping and daytime sleepiness), and AD. Mendelian randomization (MR) was used to estimate the causal effect of self-reported and accelerometer-measured sleep parameters on AD risk.Results: Overall, there was little evidence to support a causal effect of sleep traits on AD risk. There was some suggestive evidence that self-reported daytime napping was associated with lower AD risk [odds ratio (OR): 0.70, 95% confidence interval (CI): 0.50-0.99). Some other sleep traits (accelerometer-measured 'eveningness' and sleep duration, and self-reported daytime sleepiness) had ORs of a similar magnitude to daytime napping, but were less precisely estimated.Conclusions: Overall, we found very limited evidence to support a causal effect of sleep traits on AD risk. Our findings provide tentative evidence that daytime napping may reduce AD risk. Given that this is the first MR study of multiple self-report and objective sleep traits on AD risk, findings should be replicated using independent samples when such data become available. [ABSTRACT FROM AUTHOR]

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