Xingkuan Chen, Jacqueline Zi Mei Fong, Jianfeng Xu, Chengli Mou, Yunpeng Lu, Song Yang, Bao-An Song, and Yonggui Robin Chi
Journal of the American Chemical Society. June 15, 2016, Vol. 138 Issue 23, 7212-7215
Esters -- Chemical properties, Catalysis -- Research, and Chemistry
The article reports the first carbene-catalyzed dynamic kinetic resolution of alpha,alpha-disubstituted carboxylic esters with up to 99:1 er and 99% yield. The present study clearly illustrates the unique power of carbene-catalyzed reactions of readily available and easy to handle carboxylic esters.