Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system
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- Authors:
- Yue Wu
Zhenling Cui
Yen-Hua Huang
Simon J. de Veer
Andrey V. Aralov
Zhong Guo
Shayli V. Moradi
Alexandra O. Hinton
Jennifer R. Deuis
Shaodong Guo
Kai-En Chen
Brett M. Collins
Irina Vetter
Volker Herzig
Alun Jones
Matthew A. Cooper
Glenn F. King
David J. Craik
Kirill Alexandrov
Sergey Mureev - Source:
- Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
- Publication Date:
- 2022-01-01
- Language:
- English
- Abstract:
- Generic approach for rapid prototyping is essential for the progress of synthetic biology. Here the authors modify the cell-free translation system to control protein aggregation and folding and validate the approach by using single conditions for prototyping of various disulfide-constrained polypeptides.
- Subjects:
- Science
- Format:
- Academic Journal
- DOI:
- 10.1038/s41467-021-27854-9
- Database:
- Directory of Open Access Journals
- Journal:
- Nature Communications
- Volume:
- 13
- Issue:
- 1
- Page Start:
- 1
- Page Count:
- 17
- ISSN:
- 20411723
- Publisher:
- Nature Portfolio, 2022.
- Document Type:
- article
