S-phase fraction and survival benefit from adjuvant chemotherapy or radiotherapy of breast cancer
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- Authors:
- STÅL, O
SKOOG, L
RUTQVIST, L. E
CARSTENSEN, J. M
WINGREN, S
SULLIVAN, S
ANDERSSON, C
DUFMATS, M
NORDENSKJÖLD, B - Author Affiliations:
- Linköping univ., fac. health sci., dep. oncology, 581 85 Linköping, Sweden
- Source:
- British journal of cancer. 70(6):1258-1262
- Publication Date:
- 1994-01-01
- Language:
- English
- Abstract:
- Cancer chemotherapy interacts with cell proliferation, but data on the relationship between cancer cell replication and the effect of adjuvant chemotherapy are scarce. We have investigated the S-phase fractions of the primary tumour from premenopausal breast cancer patients who participated in a randomised trial comparing 12 cycles of polychemotherapy (CMF) with post-operative radiotherapy. DNA flow cytometry was performed on frozen tissues from 208 primary breast carcinomas, of which the S-phase fraction was estimated in 176 cases. There was a significantly higher benefit from CMF among patients with a high S-phase fraction (P=0.0033).
- Notes:
- Pharmacological treatments
- Subjects:
- Medical oncology
Cancérologie
Sciences biologiques et medicales
Biological and medical sciences
Sciences medicales
Medical sciences
Pharmacologie. Traitements medicamenteux
Pharmacology. Drug treatments
Anticancéreux
Antineoplastic agents
Chimiothérapie
Chemotherapy
Anticancéreux
Antineoplastic agent
Anticanceroso
Chimiothérapie
Chemotherapy
Quimioterapia
Cycle cellulaire
Cell cycle
Ciclo celular
Cytométrie flux
Flow cytometry
Citometría flujo
Etude cas
Case study
Estudio caso
Exploration
Exploración
Glande mammaire
Mammary gland
Glándula mamaria
Homme
Human
Hombre
Phase S
S Phase
Fase S
Pronostic
Prognosis
Pronóstico
Préménopause
Premenopause
Premenopausia
Radiothérapie
Radiotherapy
Radioterapia
Traitement adjuvant
Adjuvant treatment
Tratamiento adyuvante
Traitement
Treatment
Tratamiento
Tumeur maligne
Malignant tumor
Tumor maligno - Format:
- Academic Journal
- Database:
- PASCAL Archive
- Journal:
- British journal of cancer
- Volume:
- 70
- Issue:
- 6
- Page Start:
- 1258
- Page Count:
- 5
- ISSN:
- 00070920
- Publisher:
- Basingstoke: Nature Publishing Group, 1994.
- Document Type:
- Article
- Physical Description:
- print, 1 p
