Abstract
Abstract:
The first cases of intractable hiccups associated with demyelinating diseases were reported in 1979.[2] Three cases of patients with multiple sclerosis (MS) presenting with hiccups were described, and the symptom was thought to reflect disinhibition of a primitive gastrointestinal reflex by demyelinating lesions. In one such study, 8 out of 47 cases of relapsing NMOSD had intractable hiccups, compared to none in 130 cases of MS.[4] In 75% of patients with intractable hiccups, MRI detected linear medullary lesions involving the pericanal region, the AP, and the NTS. [Extracted from the article]
