Abstract
Abstract:
The guaianolide ester is a potent inhibitor of cancer cells. Lactucopicrin, a guaianolide, shows analgesic, antitussic, and sedative activities. In order to investigate its structure, ¹H and [sup 13]C NMR and 2D NMR have been carried out at a proton field strength of 400 MHz and a carbon field strength of 100 Mhz in DMSO-d[sub 6] at 20°C. Resonances for all protons and carbons have been assigned. The results of HMQC and HMBC experiments suggest that the structure of lactucopicrin is as shown in Fig. 1. Its stereostructure is verified by the X-ray experiment. ¹H and [sup 13]C NMR of lactucopicrin are reported. Its 2D NMR and X-ray are reported for the first time. KEY WORDS: NMR; HMQC; HMBC; X-ray diffraction; lactucopicrin. [ABSTRACT FROM AUTHOR]
