Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters.

Authors:: Chen X
Fong JZ
Xu J
Mou C
Lu Y
Yang S
Song BA
Chi YR
Source:: Journal of the American Chemical Society [J Am Chem Soc] 2016 Jun 15; Vol. 138 (23), pp. 7212-5. Date of Electronic Publication: 2016 Jun 02.
Publication Date:: 2016-06-15
Language:: English
Abstract:: Carbene-catalyzed reaction of carboxylic esters has the potential to offer effective synthetic solutions that cannot be readily achieved by using the more conventional aldehyde-type substrates. Here we report the first carbene-catalyzed dynamic kinetic resolution of α,α-disubstituted carboxylic esters with up to 99:1 er and 99% yield. The present study clearly illustrates the unique power of carbene-catalyzed reactions of readily available and easy to handle carboxylic esters.
Format:: Academic Journal
DOI:: 10.1021/jacs.6b00406
Database:: MEDLINE
Journal:: Journal of the American Chemical Society
Volume:: 138
Issue:: 23
Page Start:: 7212
ISSN:: 1520-5126

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