Complete resolution of a mitral valve vegetation with anticoagulation in seronegative antiphospholipid syndrome.
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- Authors:
- Ruan Y
Bridges JS
Kumar K
Raphael JA
Acharjee S
Welty FK - Source:
-
Clinical rheumatology [Clin Rheumatol] 2008 Dec; Vol. 27 (12), pp. 1577-9. Date of Electronic Publication: 2008 Aug 21. - Publication Date:
- 2008-12-01
- Language:
- English
- Abstract:
- Antiphospholipid syndrome (APS) is a disorder characterized by recurrent venous or arterial thrombosis and/or fetal loss; involvement of cardiac valves is also seen. A seronegative variant has been described previously. We report a case of a woman with recurrent pregnancy loss, prior strokes, and a negative workup for known antiphospholipid antibodies. During her current pregnancy, she presented with acute stroke and mitral valve vegetation. Her workup for antiphospholipid syndrome and other thrombophilias remained negative even after the stroke. Her mitral valve vegetation resolved completely with aspirin, heparin, and warfarin. We believe this to be the first report of complete resolution of valvular vegetation with antiplatelet and anticoagulant therapy alone in a patient with seronegative antiphospholipid syndrome. Moreover, this appears to be the first report of stroke associated with this condition.
- Subjects:
- Abortion, Habitual drug therapy
Abortion, Habitual etiology
Adult
Antiphospholipid Syndrome diagnosis
Aspirin therapeutic use
Cesarean Section
Female
Heparin therapeutic use
Humans
Infant, Newborn
Male
Pregnancy
Pregnancy Complications, Hematologic diagnosis
Stroke etiology
Warfarin therapeutic use
Anticoagulants therapeutic use
Antiphospholipid Syndrome complications
Antiphospholipid Syndrome drug therapy
Mitral Valve Insufficiency complications
Mitral Valve Insufficiency drug therapy
Pregnancy Complications, Hematologic drug therapy - Format:
- Academic Journal
- DOI:
- 10.1007/s10067-008-0991-0
- Database:
- MEDLINE
- Journal:
- Clinical rheumatology
- Volume:
- 27
- Issue:
- 12
- Page Start:
- 1577
- ISSN:
- 1434-9949
