Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters.
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- Authors:
- Xingkuan Chen
Jacqueline Zi Mei Fong
Jianfeng Xu
Chengli Mou
Yunpeng Lu
Song Yang
Bao-An Song
Yonggui Robin Chi - Source:
-
Journal of the American Chemical Society . 6/15/2016, Vol. 138 Issue 23, p7212-7215. 4p. - Publication Date:
- 2016-06-15
- Language:
- English
- Abstract:
- Carbene-catalyzed reaction of carboxylic esters has the potential to offer effective synthetic solutions that cannot be readily achieved by using the more conventional aldehyde-type substrates. Here we report the first carbene-catalyzed dynamic kinetic resolution of a,a-disubstituted carboxylic esters with up to 99:1 er and 99% yield. The present study clearly illustrates the unique power of carbene-catalyzed reactions of readily available and easy to handle carboxylic esters. [ABSTRACT FROM AUTHOR]
- Format:
- Academic Journal
- DOI:
- 10.1021/jacs.6b00406
- Database:
- Academic Search Premier
- Journal:
- Journal of the American Chemical Society
- Volume:
- 138
- Issue:
- 23
- Page Start:
- 7212
- Page Count:
- 4
- ISSN:
- 00027863
