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1 online resource (vi, 300 p.) : ill. (some col.). Digital: text file; PDF.
  • Forward.- Past.- mTOR inhibitors: a little bit of history.- Present.- The mTOR pathway .- The evolving role of mTOR inhibitors in renal cell carcinoma.- The role of mTOR inhibitors in breast cancer.- The role of mTOR inhibitors in neuroendocrine tumors.- New indications of mTOR inhibitors in rare tumors.- The role of mTOR inhibitors in the treatment of hematological malignancies.- The clinical pharmacology and toxicity profile of rapalogs.- Resistance to mTOR inhibitors.- Rational combinations of mTOR inhibitors as anticancer strategies.- Future.- Predictive biomarkers of response to mTOR inhibitors.- The potential future indication of rapamycin analogs for the treatment of other solid tumors.- mTOR inhibition beyond rapalogs.- mTOR, aging and cancer: the missing link?.- New study design for mTOR inhibitors and other biological agents.- Future directions for the development of mTOR inhibitors.
  • (source: Nielsen Book Data)
This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs. Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compounds currently under evaluation.
(source: Nielsen Book Data)
1 online resource (592 p.) : ill. (some col.).
"The Pacific Symposium on Biocomputing (PSB) 2016 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2016 will be held on January 4 – 8, 2016 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference. PSB 2016 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field."-- Provided by publisher.
online resource (xi, 395 pages) : illustrations (some color)
  • Time-lapse fluorescence microscopy of budding yeast cells / Arun Kumar and Manuel Mendoza
  • Real-time visualization and quantification of contractile ring proteins in single living cells / Reshma Davidson ... [et al.]
  • Fluorescence recovery after photo-bleaching (FRAP) and fluorescence loss in photo-bleaching (FLIP) experiments to study protein dynamics during budding yeast cell division / Alessio Bolognesi ... [et al.]
  • High-speed super-resolution imaging of live fission yeast cells / Caroline Laplante ... [et al.]
  • Monitoring chitin deposition during septum assembly in budding yeast / Irene Arcones and Cesar Roncero
  • Imaging septum formation by fluorescence microscopy / Juan Carlos Ribas and Juan Carlos G. Cortés
  • Visualization of cytokinesis events in budding yeast by transmission electron microscopy / Franz Meitinger and Gislene Pereira
  • Visualization of fission yeast cells by transmission electron microscopy / Matthias Sipiczki
  • Characterization of septin ultrastructure in budding yeast using electron tomography / Aurélie Bertin and Eva Nogales
  • Isolation of cytokinetic actomyosin rings from Saccharomyces cerevisiae and Schizosaccharomyces pombe / Junqi Huang ... [et al.]
  • Measurements of myosin-II motor activity during cytokinesis in fission yeast / Qing Tang, Luther W. Pollard, and Matthew Lord
  • In vitro biochemical characterization of cytokinesis actin-binding proteins / Dennis Zimmermann ... [et al.]
  • Characterization of cytokinetic F-BARs and other membrane-binding proteins / Nathan A. McDonald and Kathleen L. Gould
  • Analysis of three-dimensional structures of exocyst components / Johannes Lesigang and Gang Dong
  • Analysis of Rho-GTPase activity during budding yeast cytokinesis / Masayuki Onishi and John R. Pringle
  • Detection of phosphorylation status of cytokinetic components / Franz Meitinger, Saravanan Palani, and Gislene Pereira
  • Studying protein-protein interactions in budding yeast using co-immunoprecipitation / Magdalena Foltman and Alberto Sanchez-Diaz
  • Conditional budding yeast mutants with temperature-sensitive and auxin-inducible degrons for screening of suppressor genes / Asli Devrekanli and Masato T. Kanemaki
  • Synchronization of the budding yeast Saccharomyces cerevisiae / Magdalena Foltman, Iago Molist, and Alberto Sanchez-Diaz
  • Fission yeast cell cycle synchronization methods / Marta Tormos-Pérez, Livia Pérez-Hidalgo, and Sergio Moreno
  • Review of fluorescent proteins for use in yeast / Maja Bialecka-Fornal, Tatyana Makushok, and Susanne M. Rafelski
  • Visualization and image analysis of yeast cells / Steve Bagley
  • Toolbox for protein structure prediction / Daniel Barry Roche and Liam James McGuffin
  • From structure to function : a comprehensive compendium of tools to unveil protein domains and understand their role in cytokinesis / Sergio A. Rincon and Anne Paoletti.
Medical Library (Lane)
1 online resource (Page 54 ) : digital, PDF file.
Background: The established methods for detecting prostate cancer (CaP) are based on tests using PSA (blood), PCA3 (urine), and AMACR (tissue) as biomarkers in patient samples. The demonstration of ERG oncoprotein overexpression due to gene fusion in CaP has thus provided ERG as an additional biomarker. Based on this, we hypothesized that ERG protein quantification methods can be of use in the diagnosis of prostate cancer. Methods: Therefore, an antibody-free assay for ERG3 protein detection was developed based on PRISM (high-pressure high-resolution separations with intelligent selection and multiplexing)-SRM (selected reaction monitoring) mass spectrometry. We utilized TMPRSS2-ERG positive VCaP and TMPRSS2-ERG negative LNCaP cells to simulate three different sample types (cells, tissue, and post-DRE urine sediment). Results: Recombinant ERG3 protein spiked into LNCaP cell lysates could be detected at levels as low as 20 pg by PRISM-SRM analysis. The sensitivity of the PRISM-SRM assay was around approximately 10,000 VCaP cells in a mixed cell population model of VCaP and LNCaP cells. Interestingly, ERG protein could be detected in as few as 600 VCaP cells spiked into female urine. The sensitivity of the in-house enzyme-linked immunosorbent assay (ELISA) was similar to the PRISM-SRM assay, with detection of 30 pg of purified recombinant ERG3 protein and 10,000 VCaP cells. On the other hand, qRT-PCR exhibited a higher sensitivity, as TMPRSS2-ERG transcripts were detected in as few as 100 VCaP cells, in comparison to NanoString methodologies which detected ERG from 10,000 cells. Conclusions: Based on this data, we propose that the detection of both ERG transcriptional products with RNA-based assays, as well as protein products of ERG using PRISM-SRM assays, may be of clinical value in developing diagnostics and prognostics assays for prostate cancer given their sensitivity, specificity, and reproducibility.
1 online resource (1 streaming video file (40 min.) : color, sound).
  • Contents: Patterns of genetic variation in Europe and the Neolithic
  • Ancient DNA and anatomically modern humans (Challenges & Potential)
  • The Neolithic transition in Europe (Scandinavia, Iberia and Eastern Europe).
1 online resource (p.117-123 ) : digital, PDF file.
In this study, the interaction of nanomaterials with biomolecules, cells, and organisms is an enormously vital area of current research, with applications in nanoenabled diagnostics, imaging agents, therapeutics, and contaminant removal technologies. Yet the potential for adverse biological and environmental impacts of nanomaterial exposure is considerable and needs to be addressed to ensure sustainable development of nanomaterials. In this Outlook four research needs for the next decade are outlined: (i) measurement of the chemical nature of nanomaterials in dynamic, complex aqueous environments; (ii) real-time measurements of nanomaterial-biological interactions with chemical specificity; (iii) delineation of molecular modes of action for nanomaterial effects on living systems as functions of nanomaterial properties; and (iv) an integrated systems approach that includes computation and simulation across orders of magnitude in time and space.
online resource (xii, 252 pages) : illustrations (some color)
  • Library construction for mutation identification by whole-genome sequencing / Harold E. Smith
  • Fundamentals of comparative genome analysis in caenorhabditis nematodes / Eric S. Haag and Cristel G. Thomas
  • Genetic methods for cellular manipulations in C. elegans / Menachem Katz
  • Fusion PCR method for expressing genetic tools in C. elegans / Yifat Eliezer and Alon Zaslaver
  • Transposon-assisted genetic engineering with Mos1- mediated single-copy insertion (MosSCI) / Christian Frøkjær-Jensen
  • Creating genome modifications in C. elegans using the CRISPR/Cas9 system / John A. Calarco and Ari E. Friedland
  • Observing and quantifying fluorescent reporters / Michael Hendricks
  • Microbial rhodopsin optogenetic tools : application for analyses of synaptic transmission and of neuronal network activity in behavior / Caspar Glock, Jatin Nagpal, and Alexander Gottschalk
  • Simultaneous optogenetic stimulation of individual pharyngeal neurons and monitoring of feeding behavior in intact C. elegans / Nicholas F. Trojanowski and Christopher Fang-Yen
  • High-pressure freeze and freeze substitution electron microscopy in C. elegans / Laura Manning and Janet Richmond
  • Electron tomography methods for C. elegans / David H. Hall and William J. Rice
  • Microfluidic devices for behavioral analysis, microscopy, and neuronal imaging in Caenorhabditis elegans / Ross C. Lagoy and Dirk R. Albrecht
  • Tracking single C. elegans using a USB microscope on a motorized stage / Eviatar I. Yemini and André E. X. Brown
  • Imaging system for C. elegans behavior / Matthew A. Churgin and Christopher Fang-Yen
  • Method for obtaining large populations of synchronized Caenorhabditis elegans dauer larvae / Maria C. Ow and Sarah E. Hall
  • Sampling and isolation of C. elegans from the natural habitat / Nausicaa Poullet and Christian Braendle
  • Primer on prototyping / Dylan Lynch and David Biron
  • Primer on quantitative modeling / Iulia Neagu and Erel Levine.
Medical Library (Lane)
online resource (xvi, 472 pages) : illustrations ; 26 cm
  • Classes of cell-penetrating peptides / Margus Pooga and Ülo Langel
  • Penetratin story : an overview / Edmond Dupont, Alain Prochiantz, and Alain Joliot
  • Prediction of cell-penetrating peptides / Mattias Hällbrink and Mati Karelson
  • Computer-aided virtual screening and designing of cell- penetrating peptides / Ankur Gautam, Kumardeep Chaudhary, Rahul Kumar, and Gajendra Pal Singh Raghava
  • Investigating membrane interactions and structures of CPPs / Fatemeh Madani and Astrid Gräslund
  • Determining the effects of membrane-interacting peptides on membrane integrity / William C. Wimley
  • Study of CPP mechanisms by mass spectrometry / Sandrine Sagan, Chérine Bechara, and Fabienne Burlina
  • Methods to study the role of the glycocalyx in the uptake of cell-penetrating peptides / Samuel Schmidt, Rike Wallbrecher, Toin H. van Kuppevelt, and Roland Brock
  • Toxicity, immunogenicity, uptake, and kinetics methods for CPPs / Julia Uusna, Kent Langel, and Ülo Langel
  • Unraveling the mechanisms of peptide-mediated delivery of nucleic acids using electron microscopy / Helerin Margus, Carmen Juks, and Margus Pooga
  • SCARA involvement in the uptake of nanoparticles formed by cell-penetrating peptides / Henrik Helmfors, Staffan Lindberg, and Ülo Langel
  • Protein mimicry and the design of bioactive Cell- penetrating peptides / John Howl and Sarah Jones
  • Pepducins and other lipidated peptides as mechanistic probes and therapeutics / Ping Zhang, Lidija Covic, and Athan Kuliopulos
  • Identification and characterization of homing peptides using in vivo peptide phage display / Maija Hyvönen and Pirjo Laakkonen
  • Antimicrobial and antiviral applications of cell- penetrating peptides / Kalle Pärn, Elo Eriste, and Ülo Langel
  • Visualizing actin architectures in cells incubated with cell-penetrating peptides / Lin He, Peter D. Watson, and Arwyn T. Jones
  • Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro / Stine Rønholt, Mie Kristensen, and Hanne Mørck Nielsen
  • Pathway toward tumor cell-selective CPPs? / Isabel D. Alves, Manon Carré, and Solange Lavielle
  • PepFects and nickFects for the intracellular delivery of nucleic acids / Piret Arukuusk, Ly Pärnaste, Mattias Hällbrink, and Ülo Langel
  • In vitro assays to assess exon skipping in duchenne muscular dystrophy / Prisca Boisguerin, Liz O'Donovan, Michael J. Gait, and Bernard Lebleu
  • Applications of ApoB LDLR-binding domain approach for the development of CNS-penetrating peptides for alzheimer's disease / Eliezer Masliah and Brian Spencer
  • CPP-based delivery system for in vivo gene delivery / Kaido Kurrikoff, Kadi-Liis Veiman, and Ülo Langel
  • Application of CPPs for brain delivery / Artita Srimanee, Jakob Regberg, and Ülo Langel
  • Intracellular delivery of nanoparticles with cell penetrating peptides / Giuseppina Salzano and Vladimir P. Torchilin
  • Multifunctional oligoaminoamides for the receptor-specific delivery of therapeutic RNA / Judith Weber, Ulrich Lächelt, and Ernst Wagner
  • Cell penetrating peptides for chemical biological studies / Ikuhiko Nakase, Toshihide Takeuchi, and Shiroh Futaki
  • Experiences with CPP-based self assembling peptide systems for topical delivery of botulinum toxin / Jane Lee, Phil Kennedy, and Jacob M. Waugh
  • Applications of CPPs in genome modulation of plants / Alicja Ziemienowicz, Jordan Pepper, and François Eudes
  • DNA transfer into animal cells using stearylated CPP based Transfection Reagent / Kristiina Karro, Tiiu Männik, Andres Männik, and Mart Ustav
  • Live cell genomics : cell-specific transcriptome capture in live tissues and cells / Thomas J. Bell and James Eberwine
  • Live cell genomics : RNA exon-specific RNA-binding protein isolation / Thomas J. Bell and James Eberwine.
Medical Library (Lane)
1 online resource (1 streaming video file (55 min.) : color, sound).
  • Contents: Ciliopathies: multisystemic disorders caused by structural and/or functional defects of the primary cilium
  • Mutations in almost 100 genes discovered to date, no clear pattern between specific genes and specific phenotypes
  • Functional interpretation of variants critical for understanding the contribution of alleles to disease severity and pleiotropy
  • A systems-based consideration for the total amount of pathogenic variation in the ciliary proteome begins to predict clinical substructure.
1 online resource (Article No. 031003 ) : digital, PDF file.
Widespread use of silver nanoparticles raises questions of environmental impact and toxicity. Both silver particles and silver ions formed by particle dissolution may impact biological systems. Therefore it is important to understand the characteristics of silver nanoparticles and their stability in relevant media. The synthesis route can impact physical and chemical characteristics of the particles and we report the characterization and solution stability of three types of silver nanoparticles (20 nm particles with and without gold cores and 110 nm particles with gold cores) in cell culture media with serum proteins: FBS10%/RPMI. These nanoparticles were synthesized in aqueous solution and characterized using both in situ and ex situ analysis methods. Dissolution studies were carried at particle concentrations from 1 µg/ml to 50 µg/ml. Particles with gold cores had smaller crystallite size and higher apparent solubility than pure silver particles. A dissolution model was found to describe the time variation of particle size and amount of dissolved silver for particle loadings above 9 µg/ml. An effective solubility product obtained from fitting the data was higher for the 20 nm gold core particles in comparison to the pure silver or 110 nm particles. Dissolution of the nanoparticles was enhanced by presence of serum proteins contained in fetal bovine serum. In addition, the protocol of the dispersion in the medium was found to influence particle agglomeration and dissolution. Results show that particle structure can impact the concentration of dissolved silver and the dose to which cells would be exposed during in vitro studies.
1 online resource.
Yarrowia lipolytica is an oleaginous ascomycete yeast that accumulates large amounts of lipids and has potential as a biofuel producing organism. Despite a growing scientific literature focused on lipid production by Y. lipolytica, there remain significant knowledge gaps regarding the key biological processes involved. We applied a combination of metabolomic and lipidomic profiling approaches as well as microscopic techniques to identify and characterize the key pathways involved in de novo lipid accumulation from glucose in batch cultured, wild-type Y. lipolytica. We found that lipids accumulated rapidly and peaked at 48 hours during the five day experiment, concurrent with a shift in amino acid metabolism. We also report that Y. lipolytica secretes disaccharides early in batch culture and reabsorbs them when extracellular glucose is depleted. Exhaustion of extracellular sugars coincided with thickening of the cell wall, suggesting that genes involved in cell wall biogenesis may be a useful target for improving the efficiency of lipid producing yeast strains.
1 online resource.
Initial proposal summary: The evolution of antibiotic-resistant mutants among bacteria (superbugs) is a persistent and growing threat to public health. In many ways, we are engaged in a war with these microorganisms, where the corresponding arms race involves chemical weapons and biological targets. Just as advances in microelectronics, imaging technology and feature recognition software have turned conventional munitions into smart bombs, the long-term objectives of this proposal are to develop highly effective antibiotics using next-generation biomolecular modeling capabilities in tandem with novel subatomic feature detection software. Using model compounds and targets, our design methodology will be validated with correspondingly ultra-high resolution structure-determination methods at premier DOE facilities (single-crystal X-ray diffraction at Argonne National Laboratory, and neutron diffraction at Oak Ridge National Laboratory). The objectives and accomplishments are summarized.
online resource (xiii, 509 pages) : illustrations (some color)
  • Principles of cryopreservation / David E. Pegg
  • Principles of cryopreservation by vitrification / Gregory M. Fahy and Brian Wowk
  • Modeling and optimization of cryopreservation / James D. Benson
  • Principles of freeze-drying / Gerald D. J. Adams, Isobel Cook, and Kevin R. Ward
  • Use of in situ fourier transform infrared spectroscopy to study freezing and drying of cells / Willem F. Wolkers and Harriëtte Oldenhof
  • Calorimetric analysis of cryopreservation and freeze-drying formulations / Wendell Q. Sun
  • Measurement of intracellular ice formation kinetics by high-speed video cryomicroscopy / Jens O. M. Karlsson
  • Laser scanning microscopy in cryobiology / Frank Stracke, Asger Kreiner-Møller, and Heiko Zimmermann
  • Low-temperature electron microscopy : techniques and protocols / Roland A. Fleck
  • Cryopreservation of semen from domestic livestock / Harald Sieme and Harriëtte Oldenhof
  • Cryopreservation of mammalian oocytes / Victoria Keros and Barry J. Fuller
  • Vitrification : a simple and successful method for cryostorage of human blastocysts / Juergen Liebermann
  • Efficient cryopreservation of human pluripotent stem cells by surface-based vitrification / Julia C. Neubauer [and 3 others]
  • Cryopreservation of Greenshell mussel (Perna canaliculus) sperm / Serean L. Adams [and 4 others]
  • Membrane modification strategies for cryopreservation / Phillip H. Purdy and James K. Graham
  • Sperm cleanup and centrifugation processing for cryopreservation / Harald Sieme and Harriëtte Oldenhof
  • Cryopreservation of red blood cells / Johan W. Lagerberg
  • Cord blood clinical processing, cryopreservation, and storage / Heidi Elmoazzen and Jelena L. Holovati
  • Directional freezing for large volume cryopreservation / Joseph Saragusty
  • Vitrification of heart valve tissues / Kelvin G. M. Brockbank [and 3 others]
  • Cryopreservation of plant cell lines / Heinz Martin Schumacher, Martina Westphal, and Elke Heine-Dobbernack
  • Writing standard operating procedures (SOPs) for cryostorage protocols : using shoot meristem cryopreservation as an example / Keith Harding and Erica E. Benson
  • Freeze-drying of proteins / Baolin Liu and Xinli Zhou
  • Freeze-drying of lactic acid Bbacteria / Fernanda Fonseca , Stéphanie Cenard , and Stéphanie Passot
  • Freeze-drying of mammalian sperm / Levent Keskintepe and Ali Eroglu
  • Freeze-drying of decellularized deart valve tissues / Willem F. Wolkers and Andres Hilfiker.
This volume provides a variety of standard protocols used to cryopreserve or freeze-dry different types of specimens. In addition, it provides chapters focused on the fundamental principles of cryopreservation, vitrification, and freeze-drying. Several state of the art microscopic, spectroscopic as well as calorimetric methods are highlighted that can be used to study cellular and macromolecular changes in response to freezing or drying. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cryopreservation and Freeze-Drying Protocols, Third Edition serves as a practical guideline for studies on freezing and drying processes as well as preservation strategies for biological specimens.
Medical Library (Lane)
1 online resource (e0121177 ) : digital, PDF file.
More than 30% of acute myeloid leukemia (AML) patients possess activating mutations in the receptor tyrosine kinase FMS-like tyrosine kinase 3 or FLT3. A small-molecule inhibitor of FLT3 (known as quizartinib or AC220) that is currently in clinical trials appears promising for the treatment of AML. Here, we report the co-crystal structure of the kinase domain of FLT3 in complex with quizartinib. FLT3 with quizartinib bound adopts an “Abl-like” inactive conformation with the activation loop stabilized in the “DFG-out” orientation and folded back onto the kinase domain. This conformation is similar to that observed for the uncomplexed intracellular domain of FLT3 as well as for related receptor tyrosine kinases, except for a localized induced fit in the activation loop. The co-crystal structure reveals the interactions between quizartinib and the active site of FLT3 that are key for achieving its high potency against both wild-type FLT3 as well as a FLT3 variant observed in many AML patients. This co-complex further provides a structural rationale for quizartinib-resistance mutations.
1 online resource.
  • .-1 New insight of peptide vaccination in cancer immunotherapy .-2 The determinants of T cell function for effective anticancer vaccine .-3 T cell fate in the tumor microenvironment .-4 T cell receptor avidity and affinity and tumor specific TCR engineer .-5 Host genetic variation and somatic alteration associated with favorable or compromised T cell function .-6 Production of Clinical T Cell Therapies .-7 Clinical success of adoptive cell transfer therapy using tumor infiltrating lymphocytes .-8 Harnessing stem cell-like memory T cells for adoptive cell transfer therapy of cancer .-9 T cell blockade- anti-CTLA4 immunotherapy against cancer and Abscopal effect in combination therapy .-10 T cell modulation- anti-OD-1 antibodies for the treatment of cancer .-11 T cell based therapies in combination with other procedures .-12 Chimeric antigen receptor T cells CD19 CAR .-13 Hematopoietic Stem Cell transplantation as immune therapy of malignancies.
  • (source: Nielsen Book Data)
This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.
(source: Nielsen Book Data)
1 online resource (1 streaming video file (35 min.) : color, sound).
  • Contents: Introduction to genetic drift
  • Hardy-Weinberg equilibrium
  • Experimental observations of genetic drift
  • Wright-Fisher model
  • Computational simulations.
1 online resource (1 streaming video file (28 min.) : color, sound).
  • Contents: Quantifying human skeletal variation
  • Genetic & environmental basis of human skeletal variation
  • Observations about human genetic variation
  • Patterns of cranial variation vs. patterns of genetic variation
  • Evolutionary processes that shaped patterns of cranial variation
  • Humans in comparison with other taxa.
1 online resource. Digital: text file; PDF.
  • Introduction.- Introduction and prospects of Marine natural compounds.- Development of Anticancer Drugs from Marine Sources.- Seaweeds.- Bacteria and Cyanobacteria Fungal metabolites.- Sponge derived bioactive compounds Mollusk.- Soft corals.- Algae.- Tunicate.- Other marine organisms derived compounds.
  • (source: Nielsen Book Data)
This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.
(source: Nielsen Book Data)
1 online resource (1 streaming video file (37 min.) : color, sound).
  • Contents: Genetic admixture processes
  • Statistical approach to allele frequencies in admixed populations
  • General mechanistic approach to complex admixture processes
  • Human admixture: isolation, migration and sociocultural behavior
  • Genetic admixture in the evolutionary history of Homo sapiens.
1 online resource (1 streaming video file (24 min.) : color, sound).
  • Contents: Human-chimpanzee similarities
  • Human-chimpanzee genomic comparison
  • DNA duplication in human evolution
  • DNA substitution in human evolution
  • Modeling molecular evolution
  • 2 goals of comparative genomics
  • Identifying human accelerated regions (HARs).