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Software/Multimedia
1 online resource (701 p.) : ill. (some col.)
"All coordination between cells, organs, and organisms depends on successful biocommunicative processes. There are abundant cases of communication in the biological world, both within (intraspecific) and between (interspecific) single-cell and multicellular microorganisms and higher animal forms. Split into two parts, this book first looks at the history, development and progress within the field of biocommunication. The second part presents real-life case studies and investigation into examples of biocommunication in the biological world. Among the organisms covered are bacteria, fungi, plants, terrestrial and marine animals, including bonobos, chimpanzees and dolphins, as well as a new theory of communication between parts in developing embryos (cybernetic embryos). Contributions from international experts in the field provide up-to-date research and results, while in depth analysis expands on these findings to pave the way for future discoveries. As the first comprehensive review of its kind, it is perfect for undergraduates, graduates, professionals and researchers in the field of life sciences."--Publisher's website.
Book
1 online resource
Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines.ïŽ By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences.
Book
1 online resource (76 p. ) : digital, PDF file.
This report provides a status of the markets and technology development involved in growing a domestic bioenergy economy as it existed at the end of 2013. It compiles and integrates information to provide a snapshot of the current state and historical trends influencing the development of bioenergy markets. This information is intended for policy-makers as well as technology developers and investors tracking bioenergy developments. It also highlights some of the key energy and regulatory drivers of bioenergy markets.
Book
1 online resource (33 p. ) : digital, PDF file.
In order to understand the anticipated status of the industry for non-starch ethanol and renewable hydrocarbon biofuels as of the end of calendar year 2015, the National Renewable Energy Laboratory (NREL) conducted its first annual survey update of U.S. non-starch ethanol and renewable hydrocarbon biofuels producers. This report presents the results of this survey, describes the survey methodology, and documents important changes since the 2013 survey.
Book
p. 1049-1062 : digital, PDF file.
Switchgrass is a relatively high-yielding and environmentally sustainable biomass crop, but further genetic gains in biomass yield must be achieved to make it an economically viable bioenergy feedstock. Genomic selection (GS) is an attractive technology to generate rapid genetic gains in switchgrass, and meet the goals of a substantial displacement of petroleum use with biofuels in the near future. In this study, we empirically assessed prediction procedures for genomic selection in two different populations, consisting of 137 and 110 half-sib families of switchgrass, tested in two locations in the United States for three agronomic traits: dry matter yield, plant height, and heading date. Marker data were produced for the families’ parents by exome capture sequencing, generating up to 141,030 polymorphic markers with available genomic-location and annotation information. We evaluated prediction procedures that varied not only by learning schemes and prediction models, but also by the way the data were preprocessed to account for redundancy in marker information. More complex genomic prediction procedures were generally not significantly more accurate than the simplest procedure, likely due to limited population sizes. Nevertheless, a highly significant gain in prediction accuracy was achieved by transforming the marker data through a marker correlation matrix. Our results suggest that marker-data transformations and, more generally, the account of linkage disequilibrium among markers, offer valuable opportunities for improving prediction procedures in GS. Furthermore, some of the achieved prediction accuracies should motivate implementation of GS in switchgrass breeding programs.
Video
1 online resource (1 streaming video file (47 min.) : color, sound).
  • Contents: Properties of GCase: structure and function
  • Enzymology and cell biology of GCase
  • Requirements for GCase activity
  • GCase and its role in Gaucher disease
  • Genotype/Phenotype and molecular correlations
  • Therapies for Gaucher disease (enzymes, genes, chaperones).
Book
13 p. : digital, PDF file.
CouR, a MarR-type transcriptional repressor, regulates the cou genes, encoding p-hydroxycinnamate catabolism in the soil bacterium Rhodococcus jostii RHA1. The CouR dimer bound two molecules of the catabolite p-coumaroyl-CoA (K<sub>d</sub> = 11 ± 1 μM). The presence of p-coumaroyl-CoA, but neither p-coumarate nor CoASH, abrogated CouR's binding to its operator DNA <i>in vitro</i>. The crystal structures of ligand-free CouR and its p-coumaroyl-CoA-bound form showed no significant conformational differences, in contrast to other MarR regulators. The CouR-p-coumaroyl-CoA structure revealed two ligand molecules bound to the CouR dimer with their phenolic moieties occupying equivalent hydrophobic pockets in each protomer and their CoA moieties adopting non-equivalent positions to mask the regulator's predicted DNA-binding surface. More specifically, the CoA phosphates formed salt bridges with predicted DNA-binding residues Arg36 and Arg38, changing the overall charge of the DNA-binding surface. The substitution of either arginine with alanine completely abrogated the ability of CouR to bind DNA. By contrast, the R36A/R38A double variant retained a relatively high affinity for p-coumaroyl-CoA (K<sub>d</sub> = 89 ± 6 μM). Altogether, our data point to a novel mechanism of action in which the ligand abrogates the repressor's ability to bind DNA by steric occlusion of key DNA-binding residues and charge repulsion of the DNA backbone.
Book
1 online resource (p. 1-7 ) : digital, PDF file.
Illumina is the most widely used next generation sequencing technology and produces millions of short reads that contain errors. These sequencing errors constitute a major problem in applications such as de novo genome assembly, metagenomics analysis and single nucleotide polymorphism discovery. In this study, we present ADEPT, a dynamic error detection method, based on the quality scores of each nucleotide and its neighboring nucleotides, together with their positions within the read and compares this to the position-specific quality score distribution of all bases within the sequencing run. This method greatly improves upon other available methods in terms of the true positive rate of error discovery without affecting the false positive rate, particularly within the middle of reads. We conclude that ADEPT is the only tool to date that dynamically assesses errors within reads by comparing position-specific and neighboring base quality scores with the distribution of quality scores for the dataset being analyzed. The result is a method that is less prone to position-dependent under-prediction, which is one of the most prominent issues in error prediction. The outcome is that ADEPT improves upon prior efforts in identifying true errors, primarily within the middle of reads, while reducing the false positive rate.
Book
1 online resource ( p.)
  • Chapter 1: Introduction Chapter 2: Diversity and cooperative communications in body area networks Chapter 3: Ultra wideband radio channel characterisation for body-centric wireless communication Chapter 4: Sparse characterization of body-centric radio channels Chapter 5: Antenna/human body interactions in the 60 GHz band: state of knowledge and recent advances Chapter 6: Antennas for ingestible capsule telemetry Chapter 7: In vivo wireless channel modeling Chapter 8: Diversity and MIMO for efficient front-end design of body-centric wireless communications devices Chapter 9: On-body antennas and radio channels for GPS applications Chapter 10: Textile substrate integrated waveguide technology for the next-generation wearable microwave systems Chapter 11: Ultra wideband body-centric networks for localisation and motion capture applications Chapter 12: Down scaling to the nano-scale in body-centric nano-networks Chapter 13: The road ahead for body-centric wireless communication and networks .
  • (source: Nielsen Book Data)9781849199902 20161003
Body centric wireless networking and communications is an emerging 4G technology for short (1-5 m) and very short (below 1 m) range communications systems, used to connect devices worn on (or in) the body, or between two people in close proximity. It has great potential for applications in healthcare delivery, entertainment, surveillance, and emergency services. This book brings together contributions from a multidisciplinary team of researchers in the field of wireless and mobile communications, signal processing and medical measurements to present the underlying theory, implementation challenges and applications of this exciting new technology. Topics covered include: diversity and cooperative communications in body area networks; ultra wideband radio channel characterisation for body-centric wireless communication; sparse characterisation of body-centric radio channels; antenna / human body interactions in the 60 GHz band; antennas for ingestible capsule telemetry; in vivo wireless channel modelling; diversity and MIMO for efficient front-end design of body-centric wireless communications devices; on-body antennas and radio channels for GPS applications; textile substrate integrated waveguide technology for the next-generation wearable microwave systems; ultra wideband body-centric networks for localisation and motion capture application; down scaling to the nano-scale in body-centric nano-networks; and the road ahead for body-centric wireless communication and networks. .
(source: Nielsen Book Data)9781849199902 20161003
Book
8 p. : digital, PDF file.
<i>Escherichia coli</i> plays an important role as a member of the gut microbiota; however, pathogenic strains also exist, including various diarrheagenic <i>E. coli</i> pathotypes and extraintestinal pathogenic <i>E. coli</i> that cause illness outside of the GI-tract. <i>E. coli</i> have traditionally been serotyped using antisera against the ca. 186 O-antigens and 53 H-flagellar antigens. Phenotypic methods, including bacteriophage typing and O- and H- serotyping for differentiating and characterizing <i>E. coli</i> have been used for many years; however, these methods are generally time consuming and not always accurate. Advances in next generation sequencing technologies have made it possible to develop genetic-based subtyping and molecular serotyping methods for <i>E. coli</i>, which are more discriminatory compared to phenotypic typing methods. Furthermore, whole genome sequencing (WGS) of <i>E. coli</i> is replacing established subtyping methods such as pulsedfield gel electrophoresis, providing a major advancement in the ability to investigate food-borne disease outbreaks and for trace-back to sources. Furthermore, a variety of sequence analysis tools and bioinformatic pipelines are being developed to analyze the vast amount of data generated by WGS and to obtain specific information such as O- and H-group determination and the presence of virulence genes and other genetic markers.
Book
70 p. ; 21 x 30 cm.
Germ cell/heritable mutations are important regulatory endpoints for international agencies interested in protecting the health of future generations. However, germ cell mutation analysis has been hampered by a lack of efficient tools. The motivation for developing this AOP was to provide context for new assays in this field, identify research gaps and facilitate the development of new methods. In this AOP, a compound capable of alkylating DNA is delivered to the testes causing germ cell mutations and subsequent mutations in the offspring of the exposed parents. Although there are some gaps surrounding some mechanistic aspects of this AOP, the overarching AOP is widely accepted and applies broadly to any species that produces sperm.
Book
51 p. ; 21 x 30 cm.
This adverse outcome pathway details the linkage between inhibition of gonadal aromatase activity in females and reproductive dysfunction, as measured through the adverse effect of reduced cumulative fecundity and spawning. Initial development of this AOP draws heavily on evidence collected using repeat-spawning fish species. Cumulative fecundity is the most apical endpoint considered in the OECD 229 Fish Short Term Reproduction Assay. The OECD 229 assay serves as screening assay for endocrine disruption and associated reproductive impairment (OECD 2012). Cumulative fecundity is one of several variables known to be of demographic significance in forecasting fish population trends. Therefore, this AOP has utility in supporting the application of measures of aromatase, or in silico predictions of the ability to inhibit aromatase, as a means to identify chemicals with known potential to adversely affect fish populations and potentially other oviparous vertebrates.
Book
119 p. ; 21 x 30 cm.
Under physiological conditions activation of glutamate ionotropic receptors such as N-methyl-D-aspartate (NMDARs), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPARs) and kainate (KARs) is responsible for basal excitatory synaptic transmission and synaptic plasticity. However, sustained over-activation of these receptors can induce excitotoxic neuronal cell death. Increased Ca2+ influx through NMDARs promotes many pathways of toxicity due to generation of free radical species, reduced ATP production, endoplasmic reticulum (ER) stress and protein aggregation. Neuronal injury induced by over-activation of these receptors and the excessive Ca2+ influx is considered an early key event of excitotoxicity. The proposed AOP is relevant to adult neurotoxicity. The MIE has been defined as a direct binding of agonists to NMDARs or indirect, through prior activation of AMPARs and/or KARs resulting in sustained NMDARs over-activation causing excitotoxic neuronal cell death, mainly in hippocampus and cortex, two brain structures fundamental for learning and memory processes.
Book
100 p. ; 21 x 30 cm.
It is well documented and accepted that learning and memory processes rely on physiological functioning of the glutamate receptor N-methyl-D-aspartate (NMDAR). Both animal and human studies investigating NMDA itself, experiments with NMDAR antagonists and mutant mice lacking NMDAR subunits strongly support this statement (Rezvani, 2006). Activation of NMDARs results in long-term potentiation (LTP), which is related to increased synaptic strength, plasticity and memory formation in the hippocampus (Johnston et al., 2009). LTP induced by activation of NMDA receptors has been found to be elevated in the developing rodent brain compared to the mature brain, partially due to 'developmental switch' of the NMDAR 2A and 2B subunits (Johnston et al., 2009). Activation of the NMDAR also enhances brain derived neurotrophic factor (BDNF) release, which promotes neuronal survival, differentiation and synaptogenesis (Tyler et al., 2002; Johnston et al., 2009). Consequently, the blockage of NMDAR by chemical substances during synaptogenesis disrupts neuronal network formation resulting in the impairment of learning and memory processes (Toscano and Guilarte, 2005). This AOP is relevant to developmental neurotoxicity (DNT). The molecular initiating event (MIE) is described as the chronic binding of antagonist to NMDAR in neurons during synaptogenesis (development) in hippocampus (one of the critical brain structures for learning and memory formation). One of the chemicals that blocks NMDAR after chronic exposure is lead (Pb2+), a well-known developmental neurotoxicant.
Book
73 p. ; 21 x 30 cm.
Liver fibrosis is an important human health issue associated with chemical exposure. It is a typical result of chronic toxic injury and one of the considered endpoints for regulatory purposes. This AOP describes the linkage between hepatic injury caused by protein alkylation and the formation of liver fibrosis. Fibrogenesis is a long-term and complex process for which an adequate cell model is not available and an in vitro evaluation of fibrogenic potential is therefore not feasible yet. This systematic and coherent display of currently available mechanistic-toxicological information can serve as a knowledge-based repository for identification/selection/development of in vitro methods suitable for measuring key events and their relationships along the AOP and to facilitate the use of alternative data for regulatory purposes. Identified uncertainties and knowledge gaps can indicate priorities for future research.
Book
34 p. ; 21 x 30 cm.
This paper identifies opportunities to refine OECD’s indicators of air pollution and population exposure to air pollution, and their periodic production for OECD and G20 countries. First, a comprehensive review is conducted of the publicly available ground-level air monitoring data for the selected countries, including their geographic coverage, data quality, comparability, etc. Second, the paper evaluates the potential applications of ground monitoring measurements for the construction of policy-relevant and internationally comparable indicators across OECD and G20 countries. Given the limited public availability of data and the incomplete geographic coverage in countries outside of Europe and North America, this paper concludes that such data are not suitable for the development of the OECD indicators of air pollution and population exposure to air pollution that need to be harmonised across countries and over time. A hybrid approach is instead recommended as a superior alternative that draws on both satellite data combined with a chemical transport model calibrated using ground-based measurements.
Book
1 online resource.
Embodiments of the invention include methods of altering the enzymatic activity or solubility of an extremophilic enzyme or post-translationally modifying a protein of interest via using isolated or partially purified glycosyltransferases and/or post-translational modification proteins, extracts of cells comprising glycosyltransferases and/or post-translational modification proteins, and/or in cells comprising one or more glycosyltransferases and/or post-translational modification proteins.
Book
254 p. ; 21x28 cm
El programa de la OCDE sobre Análisis de los resultados medioambientales proporciona una evaluación independiente del progreso de los países para cumplir los compromisos nacionales e internacionales en materia de políticas ambientales junto con recomendaciones relevantes a dichas políticas. Las evaluaciones están dirigidas para promover el aprendizaje entre pares, estimular una mayor rendición de cuentas entre países y ante la opinión pública y para que los países mejoren su comportamiento individual y colectivo en la gestión del medio ambiente. Los análisis están avalados por un amplio espectro de datos económicos y ambientales. Cada ciclo de Análisis de los resultados medioambientales cubre todos los países miembros de la OCDE y algunos países socios. Entre las más recientes evaluaciones se encuentran: Islandia (2014), Suecia (2014) y Colombia (2014). Este informe es el tercer análisis de los resultados medioambientales de España. Evalúa el progreso hacia el desarrollo sostenible y el crecimiento verde y se centra en políticas sobre biodiversidad y resultados medioambientales del sector industrial. Contenido: Parte I. Progreso hacia el desarrollo sostenible Capítulo 1. Principales tendencias medioambientales Capítulo 2. Entorno decisorio Capítulo 3. Hacia el crecimiento verde Parte II. Progreso hacia objetivos medioambientales seleccionados Capítulo 4. Conservación y uso sostenible del medio ambiente marino y terrestre Capítulo 5. Resultados medioambientales del sector industrial