Search results

RSS feed for this result

1,257 results

1 online resource (2,080 pages) : illustrations.
  • Fundamental concepts and theories
  • Development and design methodologies
  • Tools and technologies
  • Utilization and application
  • Issues and challenges
  • Emerging trends.
Medical imaging has transformed the ways in which various conditions, injuries, and diseases are identified, monitored, and treated. As various types of digital visual representations continue to advance and improve, new opportunities for their use in medical practice will likewise evolve. Medical Imaging: Concepts, Methodologies, Tools, and Applications presents a compendium of research on digital imaging technologies in a variety of healthcare settings. This multi-volume work contains practical examples of implementation, emerging trends, case studies, and technological innovations essential for using imaging technologies for making medical decisions. This comprehensive publication is an essential resource for medical practitioners, digital imaging technologists, researchers, and medical students.
(source: Nielsen Book Data)9781522505716 20161213
1 online resource.
EBSCOhost Access limited to 1 user
1 online resource (1 streaming video file (47 min.) : color, sound).
  • Contents: Properties of GCase: structure and function
  • Enzymology and cell biology of GCase
  • Requirements for GCase activity
  • GCase and its role in Gaucher disease
  • Genotype/Phenotype and molecular correlations
  • Therapies for Gaucher disease (enzymes, genes, chaperones).
8 p. : digital, PDF file.
<i>Escherichia coli</i> plays an important role as a member of the gut microbiota; however, pathogenic strains also exist, including various diarrheagenic <i>E. coli</i> pathotypes and extraintestinal pathogenic <i>E. coli</i> that cause illness outside of the GI-tract. <i>E. coli</i> have traditionally been serotyped using antisera against the ca. 186 O-antigens and 53 H-flagellar antigens. Phenotypic methods, including bacteriophage typing and O- and H- serotyping for differentiating and characterizing <i>E. coli</i> have been used for many years; however, these methods are generally time consuming and not always accurate. Advances in next generation sequencing technologies have made it possible to develop genetic-based subtyping and molecular serotyping methods for <i>E. coli</i>, which are more discriminatory compared to phenotypic typing methods. Furthermore, whole genome sequencing (WGS) of <i>E. coli</i> is replacing established subtyping methods such as pulsedfield gel electrophoresis, providing a major advancement in the ability to investigate food-borne disease outbreaks and for trace-back to sources. Furthermore, a variety of sequence analysis tools and bioinformatic pipelines are being developed to analyze the vast amount of data generated by WGS and to obtain specific information such as O- and H-group determination and the presence of virulence genes and other genetic markers.
1 online resource (vii, 182 pages) : color illustrations
  • Preface; Contents; 1: The Protein Data Bank; 2: Seeing Is Believing: Methods of Structure Solution; 3: Visualizing the Invisible World of Molecules; 4: The Twists and Turns of DNA; 5: The Central Dogma; 6: The Secret of Life: The Genetic Code; 7: Evolution in Action; 8: How Evolution Shapes Proteins; 9: The Universe of Protein Folds; 10: Order and Chaos in Protein Structure; 11: Molecular Electronics; 12: Green Energy; 13: Peak Performance; 14: Cellular Signaling Networks; 15: GPCRs Revealed; 16: Signaling with Hormones; 17: Single-Molecule Chemistry: Enzyme Action and the Transition State
  • 18: Seven Wonders of the World of Enzymes One: Perfect Enzymes; Two: Induced Fit; Three: Form-Fitting Active Sites; Four: Allostery; Five: Substrate Channeling; Six: Chemical Cofactors; Seven: Ribozymes; 19: Building Bodies; 20: Coloring the Biological World; 21: Amazing Antibodies; 22: Attack and Defense:Weapons of the ImmuneSystem; 23: Reconstructing HIV
This book will take an evidence-based approach to current knowledge about biomolecules and their place in our lives, inviting readers to explore how we know what we know, and how current gaps in knowledge may influence the way we approach the information. Biomolecular science is increasingly important in our everyday life, influencing the choices we make about our diet, our health, and our wellness. Often, however, information about biomolecular science is presented as a list of immutable facts, discouraging critical thought. The book will introduce the basic tools of structural biology, supply real-life examples, and encourage critical thought about aspects of biology that are still not fully understood.
1 online resource (1 streaming video file (24 min.) : color, sound).
  • Contents: Uniformitarianism, Lamarckism and Darwin's theory
  • Mendel’s work and the science of genetics
  • The modern synthesis: a mechanistic basis for variation and heredity
  • Molecular biology: the age of biological information
  • Rethinking gradual progressive evolution
  • Evolutionary biology in the age of genomics
  • Eugenics, the dark chapter of evolutionary biology
  • Group-level selection and evolution of morality.
1 online resource (1 streaming video file (36 min.) : color, sound).
  • Contents: Cardiac aging in human and animal models
  • Molecular mechanisms for cardiac aging
  • Recent advances on potential interventions for cardiac aging
  • Future perspectives of cardiac aging interventions.
1 online resource (1 streaming video file (16 min.) : color, sound).
  • Contents: Niche construction: definitions and examples
  • The endomembrane system
  • Advent of cholesterol depended on oxygen
  • Ecosystems and the process of death
  • Internal niche construction
  • The swim-bladder, the lung and PTHrP
  • Niche construction and epigenetics interactions
  • Gaia hypothesis.
10 p. : digital, PDF file.
Similar to ruminants, swine have been shown to be a reservoir for Shiga toxin-producing Escherichia coli (STEC), and pork products have been linked with outbreaks associated with STEC O157 and O111:H-. STEC strains, isolated in a previous study from fecal samples of late-finisher pigs, belonged to a total of 56 serotypes, including O15:H27, O91:H14, and other serogroups previously associated with human illness. The isolates were tested by polymerase chain reaction (PCR) and a high-throughput real-time PCR system to determine the Shiga toxin (Stx) subtype and virulence-associated and putative virulence-associated genes they carried. Select STEC strains were further analyzed using a Minimal Signature E. coli Array Strip. As expected, stx<sub>2e</sub> (81%) was the most common Stx variant, followed by stx<sub>1a</sub> (14%), stx<sub>2d</sub> (3%), and stx<sub>1c</sub> (1%). The STEC serogroups that carried stx<sub>2d</sub> were O15:H27, O159:H16 and O159:H-. Similar to stx<sub>2a</sub> and stx<sub>2c</sub>, the stx<sub>2d</sub> variant is associated with development of hemorrhagic colitis and hemolytic uremic syndrome, and reports on the presence of this variant in STEC strains isolated from swine are lacking. Moreover, the genes encoding heat stable toxin (estIa) and enteroaggregative E. coli heat stable enterotoxin-1 (astA) were commonly found in 50 and 44% of isolates, respectively. The hemolysin genes, hlyA and ehxA, were both detected in 7% of the swine STEC strains. Although the eae gene was not found, other genes involved in host cell adhesion, including lpfA<sub>O113</sub> and paa were detected in more than 50% of swine STEC strains, and a number of strains also carried iha, lpfA<sub>O26</sub>, lpfA<sub>O157</sub>, fedA, orfA, and orfB. Furthermore, the present work provides new insights on the distribution of virulence factors among swine STEC strains and shows that swine may carry Stx1a-, Stx2e-, or Stx2d-producing E. coli with virulence gene profiles associated with human infections.
1 online resource (1 streaming video file (52 min.) : color, sound).
  • Contents: Application of new diagnostic techniques in clinical medicine, mainly in molecular cytogenetics of neoplasia
  • Relevant chromosomal abnormalities that impact the diagnosis and prognosis of patients with acute lymphoblastic leukemia and acute myeloblastic leukemia.
25 p. : digital, PDF file.
Microbial-mat communities in the effluent channels of Octopus and Mushroom Springs within the Lower Geyser Basin at Yellowstone National Park have been studied for nearly 50 years. The emphasis has mostly focused on the chlorophototrophic bacterial organisms of the phyla <i>Cyanobacteria</i> and <i>Chloroflexi</i>. In contrast, the diversity and metabolic functions of the heterotrophic community in the microoxic/anoxic region of the mat are not well understood. In this study we analyzed the orange-colored undermat of the microbial community of Mushroom Spring using metagenomic and rRNA-amplicon (iTag) analyses. Our analyses disclosed a highly diverse community exhibiting a high degree of unevenness, strongly dominated by a single taxon, the filamentous anoxygenic phototroph, <i>Roseiflexus</i> spp. The second most abundant organisms belonged to the <i>Thermotogae</i>, which have been hypothesized to be a major source of H-2 from fermentation that could enable photomixotrophic metabolism by <i>Chloroflexus</i> and <i>Roseiflexus</i> spp. Other abundant organisms include two members of the <i>Armatimonadetes</i> (OP10); <i>Thermocrinis</i> sp.; and phototrophic and heterotrophic members of the <i>Chloroflexi</i>. Further, an <i>Atribacteria</i> (OP9/JS1) member; a sulfate-reducing <i>Therrnodesulfovibrio</i> sp.; a <i>Planctomycetes</i> member; a member of the EM3 group tentatively affiliated with the <i>Thermotogae</i>, as well as a putative member of the <i>Arrninicenantes</i> (OP8) represented ≥ 1% of the reads. <i>Archaea</i> were not abundant in the iTag analysis, and no metagenomic bin representing an archaeon was identified. A high microdiversity of 16S rRNA gene sequences was identified for the dominant taxon, <i>Roseiflexus</i> spp. Previous studies demonstrated that highly similar <i>Synechococcus</i> variants in the upper layer of the mats represent ecological species populations with specific ecological adaptations. In conclusion, this study suggests that similar putative ecotypes specifically adapted to different niches occur within the undermat community, particularly for <i>Roseiflexus</i> spp.
1 online resource (1 streaming video file (11 min.) : color, sound).
  • Contents: History of descriptive physiology
  • Systems biology
  • The biota expansion
  • Downward causation vs. cell-cell signaling
  • Holism vs. Reductionism: philosophical views about nature
  • Molecular changes mediating evolution
  • Cell communication as mechanism of novelty
  • From phylogeny-ontogeny to homeostasis & repair
  • Homeostasis as the mechanism for evolution
  • Explicate/Implicate order.
1 online resource (1 streaming video file (10 min.) : color, sound).
  • Contents: Select epigenetic "marks" are retained from generation to generation
  • Inter- and transgenerational transmission of epigenetic marks is via germline cells
  • approximately 97 per cent of human genetic diseases are likely caused by epigenetic inheritance
  • Epigenetics allows for redefinition of terms in descriptive biology
  • Epigenetic inheritance leads to the zygote as the primary level of selection
  • The cellular-molecular approach to biology is predictive.
1 online resource (1 streaming video file (15 min.) : color, sound).
  • Contents: Tissue interactions during morphogenesis
  • Automaturation due to mechanotransduction
  • PTHrP is stretch-regulated
  • Dissociation of endoderm from mesoderm and fibrosis
  • Co-culture of endoderm and mesoderm lead to homeostasis
  • Neutral Lipid Trafficking.
1 online resource (1 streaming video file (33 min.) : color, sound).
  • Contents: Evolution of endothermy
  • PTHrP, Glucocorticoid and β-Adrenergic Receptor gene duplications
  • Hypoxia integrates respiratory and endocrine systems
  • Selection pressure for integrated physiology: lung, kidney, heart
  • Ontogeny-phylogeny of lung cell evolution
  • Swim bladder-lung functional homology
  • PTHrP is stretch-regulated
  • Chemiosmosis-homeostasis and the origins of life
  • Vertical integration of the effect of cholesterol on homeostasis
  • Cell-cell interactions and adaptation to oxygen
  • Endothermy as exaptation of oxygen adaptation
  • Physiologic homology based on cell-cell interactions.
1 online resource (1 streaming video file (5 min.) : color, sound).
  • Contents: Basis for predictive medicine
  • Utility in rational drug design & improving medical practices
  • Bioethics based on physiologic principles
  • A universal database for the natural sciences
  • The ideal human living environment.
1 online resource (1 streaming video file (41 min.) : color, sound).
  • Contents: Overview of lens anatomy and function
  • Lens macrostructure/microanatomy and lens transparency
  • Molecular mechanisms of the vertebrate lens development
  • Factors contributing to normal lens physiology
  • The role of proteins integral to lenticular transparency
  • Genetics of lens abnormalities
  • The importance of precision diagnoses in congenital lens abnormality cases
  • Next generation sequencing technologies in the diagnosis of lens abnormalities.
1 online resource (1 streaming video file (32 min.) : color, sound).
  • Contents: Graph theory and molecular structure representations
  • Molecular descriptors
  • High-throughput and virtual screening
  • Clustering and diversity selection methods
  • QSAR: quantitative structure-activity relationship models
  • Multiobjective de novo design.
1 online resource (1 streaming video file (26 min.) : color, sound).
  • Contents: The origin of life
  • Major transitions and size increase
  • Formation of cells
  • Molecules in the cellular environment
  • Complex cells
  • Conflict mediation
  • Multi level selection
  • Multicellularity
  • Origin of societies.
1 online resource (1 streaming video file (27 min.) : color, sound).
  • Contents: Functions of the kidney
  • Locations of mutations affecting renal function and homeostasis
  • Genetically linked glomerular diseases.