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1 online resource.
  • 1. Future Cities: The Blue and Biophilic .- 2. Planning the Balance of Danger and Delight .- 3. Unsustainable Bounties for the Blue: Cities to the Rescue? .- 4. Making the Marine World Visible - Fostering Emotional Connections to the Sea .- 5. Reimagining the Blue Edge .- 6. Just Blue (and Biophilic) Cities .- 7. Conclusions and Trajectories: Final Reflection on Blue, Biophilic Urbanism.
  • (source: Nielsen Book Data)9783319679549 20180122
There is a growing recognition of the contact we need with nature to be happy, healthy and to lead meaningful lives. We need that nature daily, if not hourly, and so it must be nearby to where we live and work. This is central to the concept of `biophilic cities' which is emerging as a global movement and guiding framework for city design and planning. Blue Biophilic Cities is about the promise of this movement and a kind of biophilic urbanism that is possible for cities perched on the edge of harbours and seas. In blue biophilic cities, much of the nearby nature is to be found in the marine realm. This book explores the efforts underway in a number of cities to foster new marine connections through a variety of innovative programs and initiatives. It also discusses a number of design ideas, from dynamic shoreline edges and floodable parks to living breakwaters, in order to emphasise the possibility of designing for resilience while also supporting marine biodiversity and strengthening biophilic connections to the marine world.
(source: Nielsen Book Data)9783319679549 20180122
1 online resource (xvii, 645 pages) : illustrations (chiefly color).
  • An introduction to the disease. Alzheimer’s disease therapy: present and future molecules / Awanish Kumar, Ashwini Kumar
  • Computational modeling methods for anti-Alzheimer agents. Recent advances in computational approaches for designing potential anti-Alzheimer’s agents / Sergi Gómez-Ganau, Jesús Vicente de Julián-Ortiz, Rafael Gozalbes
  • Computer-aided drug design approaches to study key therapeutic targets in Alzheimer’s disease / Agostinho Lemos, Rita Melo, Irina S. Moreira, M. Natália D. S. Cordeiro
  • Virtual screening in the search of new and potent anti-Alzheimer agents / Livia Basile
  • Molecular field topology analysis (MFTA) in the design of neuroprotective compounds / Eugene V. Radchenko, Vladimir A. Palyulin, Nikolay S. Zefirov
  • Modeling of ligands acting against specific anti-Alzheimer drug targets. Galantamine derivatives as acetylcholinesterase inhibitors: docking, design, synthesis, and inhibitory activity / Irini Doytchinova, Mariyana Atanasova, Georgi Stavrakov, Irena Philipova, Dimitrina Zheleva-Dimitrova
  • Modeling of BACE-1 inhibitors as anti-Alzheimer’s agents / Odailson Santos Paz, Thamires Quadros Froes, Franco Henrique Leite, Marcelo Santos Castilho
  • Design of anti-Alzheimer’s disease agents focusing on a specific interaction with target biomolecules / Yoshio Hamada, Kenji Usui
  • Molecular docking and molecular dynamics simulation to evaluate compounds that avoid the amyloid beta aggregation / Maricarmen Hernández Rodríguez, Leticia Guadalupe Fragoso Morales, José Correa Basurto, Martha Cecilia Rosales Hernández
  • In silico strategies to design small molecules to study beta-amyloid aggregation / Praveen P. N. Rao, Deguo Du
  • Computational approaches to understand cleavage mechanism of amyloid beta (A[beta]) peptide / Kailas Dashrath Sonawane, Maruti Jayaram Dhanavade
  • Computational modeling of gamma-secretase inhibitors as anti-Alzheimer agents / Prabu Manoharan, Nanda Ghoshal
  • Molecular modeling of tau proline-directed protein kinase (PDPK) inhibitors / Carlos Navarro-Retamal, Julio Caballero
  • Computational modelling of kinase inhibitors as anti-Alzheimer agents / Mange Ram Yadav, Mahesh A. Barmade, Rupesh V. Chikhale, Prashant R. Murumkar
  • Computational modeling of drugs for Alzheimer’s disease: design of serotonin 5-HT6 antagonists / Ádám A. Kelemen, Stefan Mordalski, Andrzej J. Bojarski, György M. Keserű
  • Computational modeling of diagnostic imaging agents for Alzheimer’s disease: molecular imaging agents for the in vivo detection of amyloid plaques in Alzheimer’s disease / Dionysia Papagiannopoulou, Dimitra Hadjipavlou-Litina
  • Special topics. Computational approaches for therapeutic application of natural products in Alzheimer’s disease / Manika Awasthi, Swati Singh, Sameeksha Tiwari, Veda P. Pandey, Upendra N. Dwivedi
  • In silico studies applied to natural products with potential activity against Alzheimer’s disease / Luciana Scotti, Marcus T. Scotti
  • Computational modeling of multi-target-directed inhibitors against Alzheimer’s disease / Akhil Kumar, Ashok Sharma
  • Neuropharmacology in flux: molecular modeling tools for understanding protein conformational shifts in Alzheimer’s disease and related disorders / Gerald H. Lushington, Frances E. S. Parker, Thomas H. W. Lushington, Nora M. Wallace
  • Computational nanotechnology: a tool for screening therapeutic nanomaterials against Alzheimer’s disease / R. Navanietha Krishnaraj, Dipayan Samanta, Rajesh K. Sani.
"This volume describes different computational methods encompassing ligand-based approaches (QSAR, pharmcophore), structure-based approaches (homology modeling, docking, molecular dynamics simulation), and combined approaches (virtual screening) with applications in anti-Alzheimer drug design. Different background topics like molecular etiologies of Alzheimer’s disease, targets for new drug development, and different cheminformatic modeling strategies are covered for completeness. Special topics like multi-target drug development, natural products, protein misfolding, and nanomaterials are also included in connection with computational modeling of anti-Alzheimer drug development. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Computational Modeling of Drugs Against Alzheimer’s Disease is a valuable resource for learning about the latest computational techniques used to study this disease"--Publisher's description.
1 online resource.
  • Introduction. Biosecurity and Risk Management. Economics of Invasive Species Damage and Damage Management. Policy and Regulation. Ecological Issues. Feeding a Hungry World: Threats to Agriculture by Invasive Vertebrate Species in the United States. Brown Tree Snakes: Methods and Approaches for Control. Burmese Pythons. Frogs (Coqui Frogs, Greenhouse Frogs, Cuban Tree Frogs, and Cane Toads). Ecology, Impacts, and Management of Invasive Rodents in the United States. Wild Pigs. Ecology of the Small Indian Mongoose (Herpestes auropunctatus) in North America. Feral Cats. Feral Goats and Sheep. European Starlings. Monk and Rose-Ringed Parakeets. Introduction History, Impacts, and Management of House Sparrows in North America. Conclusions, Challenges, and Research Needs.
  • (source: Nielsen Book Data)9781498704847 20171211
Vertebrate invasive species are important ecologically, socially, and scientifically throughout much of the globe. However, the interdiction and options for management of invasive species are driven by localized regulation at the country or even state level and thus the management of species must be framed within that context. This book is focused around the management of invasive vertebrate species in the United States, although readers will find much of the material broadly applicable to invasive species in other regions. Vertebrate invasive species cause damage to agriculture, property, natural resources, and threaten human health and safety. However, most of these species occur in the United States resulting from human-mediated activities, often being released intentionally. For the first time, the wealth of scientific information about vertebrate invasive species in the United States is summarized and synthesized in a single volume to be easily accessible to ecologists and natural resource managers. With a focus on prominent terrestrial invasive species that have a history of policy and management and highlighting contemporary issues and management, this book consists of 18 chapters written by experts from across the United States. The first section of the book focuses on overarching policy and management topics associated with vertebrate invasive species; including biosecurity threats and risk assessment, policy and regulation, and the economics of their management. The second section provides in-depth reviews of noteworthy invasive mammals, birds, amphibians, and reptiles. After finishing this book, the reader should understand the complexity of managing invasive species, the unique challenges that each new species may present, and the steps forward that may decrease the impact of these species on the environment, human health, and the economy.
(source: Nielsen Book Data)9781498704847 20171211
1 online resource.
  • (source: Nielsen Book Data)9780198808978 20180115
This edited volume assembles some of the most intriguing voices in modern conservation biology. Collectively they highlight many of the most challenging questions being asked in conservation science today, each of which will benefit from new experiments, new data, and new analyses. The book's principal aim is to inspire readers to tackle these uncomfortable issues head-on. A second goal is to be reflective and consider how the field has reacted to challenges, and to what extent these challenges advance conservation science. A concluding chapter will synthesize common themes that emerge from the experiences of the authors in these debates and discuss how best to guard against confirmation bias. The hope is that this book will lead to greater conservation of ecosystems and biodiversity by harnessing the engine of constructive scientific scepticism in service of better results.
(source: Nielsen Book Data)9780198808978 20180115
EBSCOhost Access limited to 1 user
1 online resource (567 p.) : ill. (some col.)
  • Mesenchymal stem cells for tissue regeneration / Guang Yang, Song Li and Ngan F. Huang
  • Delivery vehicles for deploying mesenchymal stem cells in tissue repair / Ben P. Hung, Michael S. Friedman and J. Kent Leach
  • Stem cells for cardiac tissue engineering / Jennifer L. Young, Karen L. Christman and Adam J. Engler
  • Engineered mechanical factors to mature pluripotent stem cell-derived cardiomyocytes / Alexandre J.S. Ribeiro, Robin E. Wilson and Beth L. Pruitt
  • Cardiovascular system : stem cells in tissue-engineered blood vessels / Rajendra Sawh-Martinez [and 5 others]
  • Stem cell-derived endothelial cells for cardiovascular regeneration / Luqia Hou and Ngan F. Huang
  • Angiogenic cytokines in the treatment of ischemic heart disease / Michael J. Paulsen and Y. Joseph Woo
  • Adipose tissue engineering and stem cells / D. Adam Young, Brian Mailey, Jennifer Baker, Anne M. Wallace and Karen L. Christman
  • Engineering cartilage : from materials to small molecules / Jeannine M. Coburn and Jennifer H. Elisseeff
  • Adult stem cells for articular cartilage tissue engineering / Sushmita Saha, Jennifer Kirkham, David Wood, Stephen Curran and Xuebin B. Yang
  • Stem cells for disc repair / Ann Ouyang, Aliza A Allon, Zorica Buser, Sigurd Berven and Jeffrey C. Lotz
  • Clinical applications of a stem cell-based therapy for oral bone reconstruction / Thomas Eshraghi and Bradley McAllister
  • Skeletal tissue engineering : progress and prospects / Nicholas J. Panetta, Deepak M. Gupta and Michael T. Longaker
  • Recent advances and future perspectives on cell reprogramming / Bilal Cakir, Kun-Yong Kim and In-Hyun Park
  • High-throughput systems for stem cell engineering / David A. Brafman, Karl Willert and Shu Chien
  • Novel methods for characterizing and sorting single stem cells from their tissue niches / Ju Li, Eric Jabart, Sachin Rangarajan and Irina Conboy
  • Label-free microfluidic techniques to isolate and screen single stem cells / Eric Jabart, Karthik Balakrishnan and Lydia L. Sohn
  • Microscale technologies for tissue engineering and stem cell differentiation / Jason W. Nichol [and 5 others]
  • Designing protein-engineered biomaterials for stem cell therapy / Lei Cai and Sarah C. Heilshorn
  • Quality control of autologous cell and tissue-based therapies / Nathalie Dusserre, Todd McAllister and Nicolas L'Heureux
  • Regulatory challenges for cell-based therapeutics / Todd McAllister, Corey Iyican and Nicolas L'Heureux.
"Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary. This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs, including cardiovascular, musculoskeletal, neurological and skin tissues. The technology platforms for studying and engineering stem cells, such as hydrogel and biomaterials development, microfluidics system and microscale patterning, are also illustrated. Regulatory challenges and quality control for clinical translation are also detailed. This book provides an comprehensive update on the advancement in the field of stem cells and regenerative medicine, and serves as a valuable resource for both researchers and students."-- Provided by publisher.
317 p. : ill. ; 21x28 cm.
  • Parte 1. El progreso hacia el desarrollo sostenible Capítulo I. Contexto y principales tendencias ambientales Capítulo II. Entorno de formulación de políticas Capítulo III. Economía y ambiente Capítulo IV. Sociedad y medio ambiente Capítulo V. Cooperación y compromisos internacionales Parte 2. Calidad ambiental de vida Capítulo VI. Aire Capítulo VII. Gestión de residuos y sustancias químicas Capítulo VIII. Recursos hídricos Capítulo IX. Biodiversidad Parte 3. Aprovechamiento de la base de recursos naturales Capítulo X. Sector agropecuario y silvicultura Capítulo XI. Sector de la pesca y los recursos hidrobiológicos Capítulo XII. Sector minero
El Programa de Evaluaciones del desempeño ambiental de la Organización de Cooperación y Desarrollo Económicos (OCDE) proporciona análisis independientes de los avances de cada país en el cumplimiento de los compromisos de sus políticas ambientales nacionales e internacionales y formula las recomendaciones pertinentes sobre esas políticas. El objetivo de las evaluaciones es promover el aprendizaje mutuo, fortalecerla rendición de cuentas de los gobiernos ante otros gobiernos y ante los ciudadanos y mejorar el desempeño ambiental de los países, tanto de forma individual como colectiva. Desde 1992, la OCDE viene realizando estas evaluaciones sobre la base de una amplia gama de datos económicos y ambientales, y cada ciclo abarca atodos los Estados miembros de esta Organización y a una serie de países socios. Algunas de las evaluaciones más recientes se han centrado en Colombia (2014), España (2015), el Brasil (2015) y Chile (2016). La Comisión Económica para América Latina y el Caribe (CEPAL) ha impulsado evaluaciones ambientales en América Latina y el Caribe en cooperación con la OCDE y ha llevado a cabo análisis similares en los estados de Amazonas y Acre en el Brasil. Este informe corresponde a la primera evaluación del desempeño ambiental del Perú. En él se examinan los avances logrados en el ámbito del desarrollo sostenible y el crecimiento verde, prestando especial atención a la ordenación ambiental (aire, residuos y sustancias químicas, agua y biodiversidad) y al aprovechamiento sostenible de la base de recursos naturales. Se analiza con mayor detenimiento el desempeño ambiental de los sectores agropecuario, pesquero y minero. Esta publicación se encuentra disponible en www.cepal.org y en www.oecd.org/env/countryreviews.
1 online resource.
  • Preface Introduction 1. Big Questions 2. What This Book Is About 3. Scientific Acronyms 4. Molecular Graphics Section I: The Old Testament of Gene Regulation 5. Evolution as a Cutout Doll Problem I 6. Evolution as a Cutout Doll Problem II 7. The Best Art 8. Intelligent Design 9. Polymers 10. LEGO (Trademark) Life 11. α/ss Proteins 12. The Inevitability of α/ss Folds 13. Evolution Puts the Y (Why) in Biology 14. Evolution Is Not Anti-Religion 15. Computers in Biology 16. The Old and New Testaments of Gene Regulation 17. Evolution as a Cutout Doll Problem III 18. Multi-subunit RNA Polymerases Book I 19. Multi-Subunit RNA Polymerases Book II 20. The Chemical Synthesis of Life 21. The RNA World 22. Ribosomes 23. The RNA-Protein World 24. Transfer RNA 25. The Three Domains of Life on Earth and Scientific Working Hypotheses 26. LUCA 27. General Transcription Factors and Promoters 28. Archaea 29. Bacteria 30. Methane and Oxygen Section II: The New Testament of Gene Regulation 31. LECA 32. Eukaryotic Multi-Subunit RNA Polymerases, General Transcription Factors and the CTD 33. Patchwork Eukaryotic Phylogenomics 34. Plants 35. The Permian-Triassic Extinction 36. The Triassic-Jurassic Extinction 37. The Cretaceous-Paleogene Extinction 38. The Paleocene-Eocene Thermal Maximum 39. Promoter Proximal Pausing and the CTD Interactome 40. Human Evolution 41. Human Cancer 42. Homology Modeling and Cryoelectron Microscopy 43. Human Extinction 44. Evolution Versus Faith 45. Concept in Biology 46. Other Books and Studies References.
  • (source: Nielsen Book Data)9780128130339 20180213
Evolution since Coding: Cradles, Halos, Barrels, and Wings describes genesis of metabolism, transcription, translation, cell structure, eukaryotic complexity, LUCA (the last universal common (cellular) ancestor), the great divergence of archaea and bacteria, LECA (the last eukaryotic common ancestor), extinction, and cancer in very simple ways. The work (almost) "synthesizes life from scratch" (since coding) and describes the tools for readers to check the author's work. As a result, readers understand living systems and their evolution in a conceptual way and are empowered to utilize powerful but accessible tools in computer-based biology. The work serves as foundational reading for a variety of researchers, academics, and students in life sciences, for example in evolution/evolutionary biology, biochemistry, genetics/molecular genetics, molecular biology, cell biology, and microbiology, as well as disciplines beyond biological science. Its approachable style makes the book accessible for introductory students and educated laypersons. Evolution since Coding is suitable to supplement college courses that mix computers, evolution, and biology from freshman to senior level.
(source: Nielsen Book Data)9780128130339 20180213
1 online resource.
  • 1. Biodiversity and taxonomy 2. Abiotic factors and ecophysiology 3. Ecosystems, energy and nutrients 4. Determining abundance and distribution 5. Population growth 6. Species interactions 7. Behavioural ecology and ecological genetics 8. Environmental pollution and perturbations 9. Conservation Biology 10. Statistics 11. Multiple choice questions 12. Answers to exercises and multiple choice questions.
  • (source: Nielsen Book Data)9780128093542 20180213
Examining Ecology: Exercises in Environmental Biology and Conservation explains foundational ecological principles using a hands-on approach that features analyzing data, drawing graphs, and undertaking practical exercises that simulate field work. The book provides students and lecturers with real life examples to demonstrate basic principles. The book helps students, instructors, and those new to the field learn about the principles of ecology and conservation by completing a series of problems. Prior knowledge of the subject is not assumed; the work requires users to be able to perform simple calculations and draw graphs. Most of the exercises in the book have been used widely by the author's own students over a number of years, and many are based on real data from published research. Exercises are succinct with a broad number of options, which is a unique feature among similar books on this topic. The book is primarily intended as a resource for students, academics, and instructors studying, teaching, and working in zoology, ecology, biology, wildlife conservation and management, ecophysiology, behavioural ecology, population biology and ecology, environmental biology, or environmental science. Students will be able to progress through the book attempting each exercise in a logical sequence, beginning with basic principles and working up to more complex exercises. Alternatively they may wish to focus on specific chapters on specialist areas, e.g., population dynamics. Many of the exercises introduce students to mathematical methods (calculations, use of formulae, drawing of graphs, calculating simple statistics). Other exercises simulate fieldwork projects, allowing users to `collect' and analyze data which would take considerable time and effort to collect in the field.
(source: Nielsen Book Data)9780128093542 20180213
1 online resource. Digital: text file; PDF.
  • Composition and Function of Cell Membranes.- History and Traditional Techniques of Studying the Structure of Cell Membranes.- Imaging membranes by High resolution Atomic Force Microscopy.- Detection of Membrane Mechanical Properties and Endocytosis by Single Molecule Force Spectroscopy.- Super-resolution Imaging of Membrane Heterogeneity.- Analysis and Applications of Single Molecule Fluorescence in Live Cell Membranes.- Lipid Cubic Phase for Membrane Protein X-ray Crystallography.- Electron Microscopic Analysis of the Plasma Membrane and Cell Surface Molecules.- Solid-state Nuclear Magnetic Resonance Spectroscopy of Membrane Proteins.- Mass Spectrometry of Membrane Proteins.- Infrared Spectroscopy for Studying Plasma Membranes.- Computer simulations to explore membrane organization and transport.- Other Modern Methods for Studying Biomembranes.
  • (source: Nielsen Book Data)9789811068225 20180129
This book highlights recent advances in and diverse techniques for exploring the plasma membrane's structure and function. It starts with two chapters reviewing the history of membrane research and listing recent advances regarding membrane structure, such as the semi-mosaic model for red blood cell membranes and the protein layer-lipid-protein island model for nucleated tissue cell membranes. It subsequently focuses on the localization and interactions of membrane components, dynamic processes of membrane transport and transmembrane signal transduction. Classic and cutting-edge techniques (e.g. high-resolution atomic force microscopy and super-resolution fluorescence microscopy) used in biophysics and chemistry are presented in a very comprehensive manner, making them useful and accessible to both researchers in the field and novices studying cell membranes. This book provides readers a deeper understanding of the plasma membrane's organization at the single molecule level and opens a new way to reveal the relationship between the membrane's structure and functions, making it essential reading for researchers in various fields.
(source: Nielsen Book Data)9789811068225 20180129
28 p. ; 21x28 cm
Le risque d’inondation de la Seine en Île-de-France constitue un risque majeur. L’OCDE estimait en 2014 qu’une inondation comparable à la crue historique de 1910 pourrait affecter jusqu'au 5 millions de citoyens et causer de 3 à 30 milliards d’euros de dommages directs selon les scénarios. Cette publication suit les progrès réalisés depuis 2014 et identifie les défis restants.
1 online resource : illustrations.
  • PART I - CHROMATIN ORGANIZATION AND DYNAMICS 1. DNA mechanics 2. DNA supercoiling (omics) 3. Chromatin and chromosome folding (experiments) 4. Chromatin and chromosome folding (modeling) 5. Chromatin and chromosome physics 6. ncRNA in chromatin folding 7. Insulators 8. Condensins and cohesins 9. Long range interactions 10. Crowding PART II - NUCLEAR ENVELOPE, NUCLEAR BODIES AND NUCLEOCYTOPLASMIC TRAFFICKING 11. Nuclear bodies 12. Nucleolus 13. Transcription factories 14. Polycomb bodies 15. Nuclear lamina 16. Other components of the nucleoskeleton 17. Nuclear pores 18. Nuclear traffic PART III - MAIN NUCLEAR FUNCTIONS 19. Chromatin folding and DNA replication 20. Chromatin folding and DNA repair 21. Chromatin folding and transcription 22. Chromatin folding and recombination 23. Chromatin folding and differentiation 24. Nuclear mechanics and mechanotransduction 25. Altered nucleus and disease PART IV - SPECIFIC FEATURES OF NUCLEAR ORGANIZATION IN MAIN MODEL ORGANISMS 26. Yeast nucleus 27. Nematode nucleus 28. Drosophila nucleus 29. Plant nucleus Conclusion and perspectives by the editors.
  • (source: Nielsen Book Data)9780128034804 20171211
Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines.
(source: Nielsen Book Data)9780128034804 20171211
1 online resource (381 p.) : ill. (some col.)
"All sorts of biological activities are processed thermodynamically, and at the utmost fundamental level, the laws of biology must be thermodynamics. However, the current laws of thermodynamics are unable to give reasonable explanation of biological processes. In order to do so, irreversible thermodynamics has been theorized to describe the basic mechanism for the origin of natural order or the development of things (related to developmental biology). The scientific definition of the system theory concept has been obtained and the properties of a biological system can be analyzed by applying principles of it. Irreversible thermodynamics and system theory act as the theoretical foundation for theoretical biology. By applying principles of irreversible thermodynamics and system theory, the axiomatic theory of biology has been developed."--Publisher's website.
1 online resource (649 p.) : ill. (chiefly col.)
"The Pacific Symposium on Biocomputing (PSB) 2018 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2018 will be held on January 3 – 7, 2018 in Kohala Coast, Hawaii. PSB 2018 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field."--Publisher's website.
1 online resource.
  • INTRODUCTION BY THE EDITORS. Introducing the New Biosocial Landscape-- Meloni, Cromby, Fitzgerald, and Lloyd.- SECTION I: History of the Biology/Society Relationship.- Chapter 1.Models, Metaphors, Lamarckisms and the Emergence of `Scientific Sociology'-- Snait Gissis.- Chapter 2.The transcendence of the social: Durkheim, Weismann and the Purification of Sociology-- Maurizio Meloni.- Chapter 3. Biology, Social Science, and Population in Late Nineteenth- and Early Twentieth-Century Britain-- Chris Renwick.- Chapter 4. The concept of plasticity in the history of the nature-nurture debate in the early 20th century-- Antonine Nicoglou.- Chapter 5. An Evolving, Evolutionary Science of Human Differences-- Jonathan Marks.- Chapter 6. Experimenting in the Biosocial: The Strange Case of Twin Research-- Will Viney.- Chapter 7. Histories and meanings of Epigenetics-- Tatjana Buklijas.- SECTION II. Genomics, Postgenomics, Epigenetics and Society.- Chapter 8. Scrutinizing the Epigenetics Revolution-- Maurizio Meloni and Giuseppe Testa, .- Chapter 9. Social & Behavioral Epigenetics: Evolving Perspectives on Nature-Nurture Interplay, Plasticity, and Inheritance-- Frances Champagne.- Chapter 10. Molecular Multicultures-- Amy Hinterberger.- Chapter 11. The First Thousand Days: Epigenetics in the Age of Global Health-- Michelle Pentecost.- Chapter 12. Genetics, epigenetics and social justice in education: learning as a complex biosocial phenomenon-- Deborah Youdell.- Chapter 13. Genetics, epigenetics and social justice in education: learning as a complex biosocial phenomenon-- Sabina Leonelli.- SECTION III. Neuroscience: brain, culture and social relations.- Chapter 14. Proposal for a Critical Neuroscience-- Jan Slaby and Suparna Choudhury.- Chapter 15. On the Neurodisciplines of Culture-- Fernando Vidal and Francisco Ortega.- Chapter 16. Affective Neuroscience as Sociological Inquiry?-- - Christian Von Scheve.- Chapter 17. Mechanisms of Embodiment in Religious Belief and Practice: "Bio-looping" in Candomble Trance and Possession-- Rebecca Seligman.- Chapter 18. Experimental Entanglements: Social Science and Neuroscience beyond Interdisciplinarity-- Des Fitzgerald and Felicity Callard.- Chapter 19 Developing Schizophrenia-- John Cromby.- Chapter 20. Epigenetics and the suicidal brain: reconsidering context in an emergent style of reasoning-- Stephanie Lloyd and Eugene Raikhel.- SECTION IV. Social Epidemiology.- Chapter 21. The embodiment dynamic over the lifecourse: a case for examining cancer aetiology-- Michelle Kelly-Irving & Cyrille Delpierre.- Chapter 22. Epigenetic signatures of socioeconomic status across the lifecourse-- Silvia Stringhini and Paolo Vineis.- Chapter 23. An intergenerational perspective on social inequality in health and life opportunities: the maternal capital model-- Jonathan Wells and Akanksha Marphatia.- Chapter 24. Quantifying social influences throughout the life-course: action, structure and `omics'-- Mike Kelly and Rachel Kelly.- Chapter 25 Health inequalities and the interplay of socioeconomic factors and health in the life course-- Rasmus Hoffmann, Hannes Kroger, Eduwin Pakpahan.- SECTION V. Medicine and Society.- Chapter 26. Universal Biology, Local Society? Notes from Anthropology-- Patrick Bieler, Jorg Niewohner.- Chapter 27.Big Data and Biomedicine-- Nadine Levin.- Chapter 28. Personalised and Precision Medicine: What kind of society does it take?-- Barbara Prainsack.- Chapter 29. Emergent postgenomic bodies and their (non)scalable environments-- Megan Warin and Aryn Martin.- Chapter 30. The vitality of disease-- Ayo Wahlberg.- Chapter 31. Bioethnography: A How-To Guide for the Twenty-First Century-- Liz Roberts and Camilo Sanz.- SECTION VI.Contested Sites/Future Perspectives.- Chapter 32. The Postgenomic Politics of Race-- Catherine Bliss.- Chapter 33. Of Rats and Women: Narratives of Motherhood in Environmental Epigenetics-- Martha Kenney and Ruth Muller.- Chapter 34. Ancestors and Identities: DNA, Genealogy, and Stories-- Jessica Bardill.- Chapter 35. Species of Biocapital, 2008 and Speciating Biocapital, 2017-- Stefan Helmreich with a postcript by Nicole Labruto.- Chapter 36. Human Tendencies-- Ed Cohen.- Chapter 37. Ten theses on the subject of biology and politics: conceptual, methodological, and biopolitical considerations-- Samantha Frost.
  • (source: Nielsen Book Data)9781137528780 20171211
This comprehensive handbook synthesizes the often-fractured relationship between the study of biology and the study of society. Bringing together a compelling array of interdisciplinary contributions, the authors demonstrate how nuanced attention to both the biological and social sciences opens up novel perspectives upon some of the most significant sociological, anthropological, philosophical and biological questions of our era. The six sections cover topics ranging from genomics and epigenetics, to neuroscience and psychology to social epidemiology and medicine. The authors collaboratively present state-of-the-art research and perspectives in some of the most intriguing areas of what can be called biosocial and biocultural approaches, demonstrating how quickly we are moving beyond the acrimonious debates that characterized the border between biology and society for most of the twentieth century. This landmark volume will be an extremely valuable resource for scholars and practitioners in all areas of the social and biological sciences.The chapter 'Ten Theses on the Subject of Biology and Politics: Conceptual, Methodological, and Biopolitical Considerations' is open access under a CC BY 4.0 license via link.springer.com.Versions of the chapters 'The Transcendence of the Social', 'Scrutinizing the Epigenetics Revolution', 'Species of Biocapital, 2008, and Speciating Biocapital, 2017' and 'Experimental Entanglements: Social Science and Neuroscience Beyond Interdisciplinarity' are available open access via third parties. For further information please see license information in the chapters or on link.springer.com.
(source: Nielsen Book Data)9781137528780 20171211
1 online resource.
  • 1. Fundamentals of protein and cell interactions in biomaterials Part 1 Proteins in biomaterials mimicking the extra cellular matrix 2. Extracellular matrix constitution and function for tissue regeneration and repair 3. Surface functionalization of biomaterials for tissue regeneration and repair 4. Bioengineered peptide biomaterials for tissue regeneration and repair Part 2 Protein-based biomaterials for tissue regeneration and repair 5. Collagen-based biomaterials for tissue regeneration and repair 6. Fibrin-Based Biomaterials for tissue regeneration and repair 7. Fibrous protein-based biomaterials (silk, keratin, elastin and resilin proteins) for tissue regeneration and repair Part 3 Processing of peptides and proteins as biomaterials 8. Fabrication of nanofibres and nanotubes for tissue regeneration and repair 9. Peptide and protein printing for tissue regeneration and repair Part 4 Bioengineering of proteins and peptides 10. Self-assembled peptides for tissue regeneration and repair 11. Collagen-like materials for tissue regeneration and repair 12. Elastin-like materials for tissue regeneration and repair 13. Mussel inspired Biomaterials (bioadhesives) for tissue regeneration and repair Part 5 Antimicrobial peptides (AMP) based biomaterial 14. AMP biomaterial coatings for tissue regeneration and repair 15. AMP as hydrogels for tissue regeneration and repair.
  • (source: Nielsen Book Data)9780081008034 20171204
Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology.
(source: Nielsen Book Data)9780081008034 20171204
1 online resource (153 p.) : ill. (some col.)
"Systems biology combines computational and experimental approaches to analyze complex biological systems and focuses on understanding functional activities from a systems-wide perspective. It provides an iterative process of experimental measurements, data analysis, and computational simulation to model biological behavior. This book provides explained protocols for high-throughput experiments and computational analysis procedures central to cancer systems biology research and education. Readers will learn how to generate and analyze high-throughput data, therapeutic target protein structure modeling and docking simulation for drug discovery. This is the first practical guide for students and scientists who wish to become systems biologists or utilize the approach for cancer research."-- Provided by publisher.
28 p. ; 21x28 cm
The risk of the Seine flooding the Ile de France region is a major one. In 2014, the OECD estimated that flooding comparable to the historic 1910 flood could affect up to 5 million citizens and cause damage costing up to 30 billion euros. This update tracks the progress made since 2014 and identifies remaining challenges.
1 online resource.
  • ""Cover""; ""Title Page""; ""Copyright Page""; ""Contents""; ""List of Contributors""; ""Preface""; ""References""; ""Chapter 1
  • Reproducibility in Biomedical Research""; ""1.1
  • Introduction""; ""1.2
  • Defining Reproducibility""; ""1.2.1
  • A New Lexicon for Reproducibility""; ""
  • Methods Reproducibility""; ""
  • Results Reproducibility""; ""
  • Inferential Reproducibility""; ""
  • Bayesian Paradigms in Reproducibility""; ""1.3
  • Discipline Specific Terminology in the Biomedical Sciences?""
  • ""1.4
  • Experimental Factors in Addition to Statistics That Affect Reproducibility""""1.4.1
  • Unknown Unknowns Affecting Reproducibility""; ""
  • The Crabbe Mouse Study""; ""
  • Reproducibility Confounds in RNA Interference""; ""
  • Caenorhabditis Lifespan""; ""1.4.2
  • Known Unknowns: Tacit Expertize""; ""1.4.3
  • Diminishing Effects: Regression to the Mean""; ""1.4.4
  • Overinterpretation of Effects on Secondary Endpoints in Studies""; ""1.5
  • The Impact of the Internet on the Evolution of Research Practicesâ#x80; #x94; Databases and Third Party Analyses""; ""1.5.1
  • Data Input""
  • ""1.5.2
  • Data Curation""""1.5.3
  • Cross-Database Integration""; ""1.5.4
  • Analytical Tools""; ""1.6
  • The Reproducibility Problem""; ""1.6.1
  • Factors Contributing to the Reproducibility Problem""; ""1.6.2
  • Human Contributions to the Reproducibility Problem""; ""
  • Litigation in Basic Biomedical Research""; ""1.6.3
  • The Impact of the Internet on Publishing and Disseminating Information""; ""
  • High and Low Profile Journals""; ""1.7
  • The Literature on Reproducibility in Biomedical Research""; ""1.7.1
  • An Age-Old Concern""; ""1.7.2
  • Concerns in the 21st Century""
  • ""1.7.3
  • Reproducibility in the 21st Century: Origins, Scope and Momentum""""
  • Why Most Published Research Findings are False""; ""
  • Believe it or not: How Much can we Rely on Published Data on Potential Drug Targets?""; ""
  • Drug Development: Raise Standards for Preclinical Cancer Research""; ""
  • Reproducibility: An Academic Viewpoint""; ""
  • Reproducibility in the Psychological Sciences""; ""
  • Researcher Awareness of Fraud""; ""1.8
  • Is There a Reproducibility Crisis?""; ""1.9
  • Trouble at the Laboratory?""; ""1.10
  • Retractions""
  • ""1.10.1
  • RetractionWatch""""1.10.2
  • Continued Citation of Retracted Publications""; ""1.10.3
  • The Spectrum of Irreproducibility""; ""1.10.4
  • Research Misconduct""; ""1.10.5
  • Fraud""; ""1.10.6
  • Notable Examples of Fraudâ#x80; #x94; Biomedical Researchers Behaving Badly""; ""
  • MMR Vaccine: Andrew Wakefieldâ#x80; #x94; Royal Free Hospital""; ""
  • Embryonic Stem Cells: Hwang Woo-Sukâ#x80; #x94; Seoul National University""; ""
  • Environment and Human Behavior: Diederik Stapelâ#x80; #x94; Tilburg University""
  • ""
  • Stimulus-Triggered Acquisition of Pluripotency (STAP): Haruko Obokataâ#x80; #x94; RIKEN Institute""
Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences.
1 online resource (541 p.) : ill. (some col.)
"This unique story offers an introductory conversation to genetics, embryology and evolution, taking us on a historical journey of biology through the ages. Using a series of dialogues between the Greek philosopher Democritus and his disciple Alkimus, we travel through time visiting eminent scientists throughout the centuries, from Lazzaro Spallanzani and Theodor Boveri to Francis Crick, Max Perutz and Christiane Nüsslein–Volhard. We find ourselves at the intersection of competing theories in biology and witness the progression from the debunking the theory of spontaneous generation to the mapping of the genome. Attention is given not only to the great successes in the field but also to the equally important and exciting failures. Originally published in Hungarian, The Story of Genetics, Development and Evolution provides a historical background to the life sciences, with complex scientific concepts stripped down and explained carefully for academics and anyone interested in going back to the roots and philosophies of scientific progress."-- Provided by publisher.
VIII, 322 p. 40 ill., 34 illus. in color : online resource. Digital: text file; PDF.
  • Promoters and terminator discovery and engineering.- Engineering and Evolution of Saccharomyces cerevisiae to Produce Biofuels and Chemicals.- Corynebacterium glutamicum for Sustainable Bioproduction: From Metabolic Physiology to Systems Metabolic Engineering.- Orthogonal Protein Translation Using Pyrrolysyl-tRNA Synthetases for Single and Multiple-Noncanonical Amino Acid Mutagenesis.- Synthetic Biology for Cell-Free Biosynthesis: Fundamentals of Designing Novel In Vitro Multi-Enzyme Reaction Networks.- Molecular engineering of synthetic metabolic pathways.- Pathway Design, Engineering and Optimization.- Xenobiology: State-of-the-art, Ethics and Philosophy of new-to-nature organisms.
  • (source: Nielsen Book Data)9783319553177 20171211
This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science.Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification.In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
(source: Nielsen Book Data)9783319553177 20171211