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1 online resource (701 p.) : ill. (some col.)
"All coordination between cells, organs, and organisms depends on successful biocommunicative processes. There are abundant cases of communication in the biological world, both within (intraspecific) and between (interspecific) single-cell and multicellular microorganisms and higher animal forms. Split into two parts, this book first looks at the history, development and progress within the field of biocommunication. The second part presents real-life case studies and investigation into examples of biocommunication in the biological world. Among the organisms covered are bacteria, fungi, plants, terrestrial and marine animals, including bonobos, chimpanzees and dolphins, as well as a new theory of communication between parts in developing embryos (cybernetic embryos). Contributions from international experts in the field provide up-to-date research and results, while in depth analysis expands on these findings to pave the way for future discoveries. As the first comprehensive review of its kind, it is perfect for undergraduates, graduates, professionals and researchers in the field of life sciences."--Publisher's website.
48 p. : ill. ; 21x28 cm.
Les Examens environnementaux de l’OCDE sont des évaluations indépendantes des progrès accomplis par les pays pour tenir leurs objectifs environnementaux. Ces examens sont destinés à favoriser les échanges de bonnes pratiques, à aider les gouvernements à rendre compte de leurs politiques et à améliorer la performance environnementale, individuelle et collective, des pays. Les analyses s’appuient sur un large éventail de données économiques et environnementales. Au cours de chaque cycle d’examens environnementaux, l’OCDE passe en revue l’ensemble de ses pays membres ainsi que certains pays partenaires. Les derniers pays examinés sont le Brésil (2015), les Pays-Bas (2015) et la France (2016). Ce rapport est le deuxième examen environnemental du Chili. Il évalue ses progrès en matière de développement durable et de croissance verte, avec un accent particulier sur le changement climatique et sur la conservation et l’exploitation durable de la biodiversité. Cette version française est une version abrégée de la version originale de la publication, OECD Environmental Performance Reviews: Chile 2016. Elle inclut notamment l'avant-propos, le résumé et les recommandations qui donne une vue d'ensemble du rapport.
1 online resource (326 pages) : illustrations.
  • History of infectious diseases / Maria Ines Zanoli Sato
  • Global environmental change and emerging infectious diseases: macrolevel drivers and policy responses / Catherine Machalaba, Cristina Romanelli, Peter Stoett
  • Climate change-associated conflict and infectious disease / Devin C. Bowles
  • Waterborne diseases and climate change: impact and implications / Maha Bouzid
  • Environmental change and the emergence of infectious diseases: a regional perspective from South America / Ulisses Confalonieri, Júlia Alves Menezes, Carina Margonari
  • Infectious diseases and climate vulnerability in Morocco: governance and adaptation options / Mohamed Behnassi [and 4 others]
  • Emergence of the Ebola virus disease in West Africa / Samir Dervisevic
  • Rift Valley Fever and the changing environment: a case study in East Africa / Johanna Lindahl [and 3 others]
  • Climate change effects on human health with a particular focus on vector-borne diseases and malaria in Africa: a case study from Kano State, Nigeria investigating perceptions about links between malaria epidemics, weather variables, and climate change / Salisu Lawal Halliru
  • Are climate change adaptation policies a game changer?: a case study of perspectives from public health officials in Ontario, Canada / Chris G. Buse.
Climate change is one of the most widely debated and worrisome topics of our time. As environmental changes become more prevalent, there has been evidence to suggest that there is a correlation between the environment and a substantial increase of infectious diseases and viruses around the globe. Examining the Role of Environmental Change on Emerging Infectious Diseases and Pandemics investigates the impact of climate change in relation to the emergence and spread of global diseases. Highlighting epidemiological factors and policies to govern epidemics and pandemics, this publication is a critical reference source for medical professionals, students, environmental scientists, advocates, policy makers, academics, and researchers.
(source: Nielsen Book Data)9781522505532 20161213
20 p.
This Policy Paper describes the relatively new phenomenon of publicly-capitalised green investment banks and examines why they are being created and how they are mobilising private investment. It draws on the OECD report “Green Investment Banks: Scaling up Private Investment in Low-carbon, Climate-resilient Infrastructure".
1 online resource
Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines.ïŽ By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences.
72 p. : ill. ; 21x28 cm.
  • Foreword
  • Abbreviations
  • Executive summary
  • Increasing the longevity of wearing courses
  • Epoxy-asphalt road surfacing field trials
  • Field trials with high-performance cementitious materials
  • Working Group members.
This report is the third and final output of a ten-year international research project studying the costs and viability of long-life road pavement surfacings. It describes the results of tests conducted with epoxy asphalt and high performance cementitious materials (HPCM) on real road sections in France, New Zealand and the United Kingdom. The project was initiated to address a growing problem for road administrations and road users: frequent closures of roadways for repairs and repaving as a result of surface pavements that have improved but still barely kept up with increased loads and traffic density.
1 online resource (2,080 pages) : illustrations.
  • Fundamental concepts and theories
  • Development and design methodologies
  • Tools and technologies
  • Utilization and application
  • Issues and challenges
  • Emerging trends.
Medical imaging has transformed the ways in which various conditions, injuries, and diseases are identified, monitored, and treated. As various types of digital visual representations continue to advance and improve, new opportunities for their use in medical practice will likewise evolve. Medical Imaging: Concepts, Methodologies, Tools, and Applications presents a compendium of research on digital imaging technologies in a variety of healthcare settings. This multi-volume work contains practical examples of implementation, emerging trends, case studies, and technological innovations essential for using imaging technologies for making medical decisions. This comprehensive publication is an essential resource for medical practitioners, digital imaging technologists, researchers, and medical students.
(source: Nielsen Book Data)9781522505716 20161213
48 p.
This study was one of the first attempts to evaluate and quantify the benefits of transboundary co-operation between Georgia and Azerbaijan. A specific framework for inventorying these benefits, taking into account all the different dimensions of transboundary water management, was built and applied to the major transboundary water bodies. Though a thorough assessment of the costs and benefits of transboundary co-operation in the two selected cases was not possible due to the lack of some quantitative and economic data, the assessment results highlighted the importance of promoting the integration of economic thinking in transboundary water management. The present and future prospects for transboundary co-operation on water management are still very positive: the two countries are working on a Transboundary Agreement, which will provide the necessary regulatory framework for co-operation and, most importantly, will set up a Joint Commission on Sustainable Use and Protection of the Kura River Basin. The outcomes of this study allowed for the identification of priorities for future work on transboundary co-operation between Georgia and Azerbaijan, and namely, support to developing guidelines on mechanisms to update databases, but also on new tools and systems.
1 online resource (31 p).
Global poverty is becoming increasingly concentrated in Sub-Saharan Africa and among households engaged in subsistence agriculture in environments characterized by uncertainty. Understanding how to achieve sustainable increases in household incomes in this context is key to ending extreme poverty. Uganda offers important lessons in this regard. Uganda experienced conflict, drought, and price volatility in the decade from 2003 to 2013, while at the same time experiencing the second fastest percentage point reduction in extreme poverty per year in Sub-Saharan Africa. This study analyzes a nationally representative panel of 2,356 households visited four times between 2006 to 2012, in combination with data on conflict events, weather, and prices. The study describes the type of income growth households experienced and assesses the importance of these external events in determining progress. The study finds substantial growth in agricultural incomes, particularly among poorer households. Many of the gains in agricultural income growth came about because of good weather, peace, and prices, and not technological change or profound changes in agricultural production. Therefore, although overall progress during this period was good, there were years in which average income growth was negative. This was particularly the case in the poorer and more vulnerable Northern and Eastern regions, and thus their overall income growth was also slower.
1 online resource (76 p. ) : digital, PDF file.
This report provides a status of the markets and technology development involved in growing a domestic bioenergy economy as it existed at the end of 2013. It compiles and integrates information to provide a snapshot of the current state and historical trends influencing the development of bioenergy markets. This information is intended for policy-makers as well as technology developers and investors tracking bioenergy developments. It also highlights some of the key energy and regulatory drivers of bioenergy markets.
1 online resource (33 p. ) : digital, PDF file.
In order to understand the anticipated status of the industry for non-starch ethanol and renewable hydrocarbon biofuels as of the end of calendar year 2015, the National Renewable Energy Laboratory (NREL) conducted its first annual survey update of U.S. non-starch ethanol and renewable hydrocarbon biofuels producers. This report presents the results of this survey, describes the survey methodology, and documents important changes since the 2013 survey.
p. 1049-1062 : digital, PDF file.
Switchgrass is a relatively high-yielding and environmentally sustainable biomass crop, but further genetic gains in biomass yield must be achieved to make it an economically viable bioenergy feedstock. Genomic selection (GS) is an attractive technology to generate rapid genetic gains in switchgrass, and meet the goals of a substantial displacement of petroleum use with biofuels in the near future. In this study, we empirically assessed prediction procedures for genomic selection in two different populations, consisting of 137 and 110 half-sib families of switchgrass, tested in two locations in the United States for three agronomic traits: dry matter yield, plant height, and heading date. Marker data were produced for the families’ parents by exome capture sequencing, generating up to 141,030 polymorphic markers with available genomic-location and annotation information. We evaluated prediction procedures that varied not only by learning schemes and prediction models, but also by the way the data were preprocessed to account for redundancy in marker information. More complex genomic prediction procedures were generally not significantly more accurate than the simplest procedure, likely due to limited population sizes. Nevertheless, a highly significant gain in prediction accuracy was achieved by transforming the marker data through a marker correlation matrix. Our results suggest that marker-data transformations and, more generally, the account of linkage disequilibrium among markers, offer valuable opportunities for improving prediction procedures in GS. Furthermore, some of the achieved prediction accuracies should motivate implementation of GS in switchgrass breeding programs.
1 online resource (1 streaming video file (47 min.) : color, sound).
  • Contents: Properties of GCase: structure and function
  • Enzymology and cell biology of GCase
  • Requirements for GCase activity
  • GCase and its role in Gaucher disease
  • Genotype/Phenotype and molecular correlations
  • Therapies for Gaucher disease (enzymes, genes, chaperones).
13 p. : digital, PDF file.
CouR, a MarR-type transcriptional repressor, regulates the cou genes, encoding p-hydroxycinnamate catabolism in the soil bacterium Rhodococcus jostii RHA1. The CouR dimer bound two molecules of the catabolite p-coumaroyl-CoA (K<sub>d</sub> = 11 ± 1 μM). The presence of p-coumaroyl-CoA, but neither p-coumarate nor CoASH, abrogated CouR's binding to its operator DNA <i>in vitro</i>. The crystal structures of ligand-free CouR and its p-coumaroyl-CoA-bound form showed no significant conformational differences, in contrast to other MarR regulators. The CouR-p-coumaroyl-CoA structure revealed two ligand molecules bound to the CouR dimer with their phenolic moieties occupying equivalent hydrophobic pockets in each protomer and their CoA moieties adopting non-equivalent positions to mask the regulator's predicted DNA-binding surface. More specifically, the CoA phosphates formed salt bridges with predicted DNA-binding residues Arg36 and Arg38, changing the overall charge of the DNA-binding surface. The substitution of either arginine with alanine completely abrogated the ability of CouR to bind DNA. By contrast, the R36A/R38A double variant retained a relatively high affinity for p-coumaroyl-CoA (K<sub>d</sub> = 89 ± 6 μM). Altogether, our data point to a novel mechanism of action in which the ligand abrogates the repressor's ability to bind DNA by steric occlusion of key DNA-binding residues and charge repulsion of the DNA backbone.
136 p. : ill. ; 21x28 cm.
  • Foreword
  • Abbreviations
  • Executive summary
  • The potential effects of climate change on transport infrastructure
  • Transport infrastructure: Climate and extreme weather impacts and costs
  • Adaptation frameworks for transport infrastructure: Linking vulnerability assessment, risk management and performance objectives
  • Managing climate change uncertainty in transport infrastructure design and network planning
  • Glossary
  • Working Group Members.
This report addresses the fundamental challenges that climate change poses to infrastructure owners, who face two major challenges. First, they must ensure continued asset performance under sometimes significantly modified climate conditions that may decrease the present value of their networks or increase maintenance and refurbishment costs. Second, they must build new assets in the context of changing and uncertain climate variables. This creates a risk of over- or under-specification of infrastructure design standards, potentially resulting in non-productive investments or network service degradation. This report investigates strategies that can help transport authorities contain network performance risks inherent in changing patterns of extreme weather.
1 online resource (p. 1-7 ) : digital, PDF file.
Illumina is the most widely used next generation sequencing technology and produces millions of short reads that contain errors. These sequencing errors constitute a major problem in applications such as de novo genome assembly, metagenomics analysis and single nucleotide polymorphism discovery. In this study, we present ADEPT, a dynamic error detection method, based on the quality scores of each nucleotide and its neighboring nucleotides, together with their positions within the read and compares this to the position-specific quality score distribution of all bases within the sequencing run. This method greatly improves upon other available methods in terms of the true positive rate of error discovery without affecting the false positive rate, particularly within the middle of reads. We conclude that ADEPT is the only tool to date that dynamically assesses errors within reads by comparing position-specific and neighboring base quality scores with the distribution of quality scores for the dataset being analyzed. The result is a method that is less prone to position-dependent under-prediction, which is one of the most prominent issues in error prediction. The outcome is that ADEPT improves upon prior efforts in identifying true errors, primarily within the middle of reads, while reducing the false positive rate.
1 online resource ( p.)
  • Chapter 1: Introduction Chapter 2: Diversity and cooperative communications in body area networks Chapter 3: Ultra wideband radio channel characterisation for body-centric wireless communication Chapter 4: Sparse characterization of body-centric radio channels Chapter 5: Antenna/human body interactions in the 60 GHz band: state of knowledge and recent advances Chapter 6: Antennas for ingestible capsule telemetry Chapter 7: In vivo wireless channel modeling Chapter 8: Diversity and MIMO for efficient front-end design of body-centric wireless communications devices Chapter 9: On-body antennas and radio channels for GPS applications Chapter 10: Textile substrate integrated waveguide technology for the next-generation wearable microwave systems Chapter 11: Ultra wideband body-centric networks for localisation and motion capture applications Chapter 12: Down scaling to the nano-scale in body-centric nano-networks Chapter 13: The road ahead for body-centric wireless communication and networks .
  • (source: Nielsen Book Data)9781849199902 20161003
Body centric wireless networking and communications is an emerging 4G technology for short (1-5 m) and very short (below 1 m) range communications systems, used to connect devices worn on (or in) the body, or between two people in close proximity. It has great potential for applications in healthcare delivery, entertainment, surveillance, and emergency services. This book brings together contributions from a multidisciplinary team of researchers in the field of wireless and mobile communications, signal processing and medical measurements to present the underlying theory, implementation challenges and applications of this exciting new technology. Topics covered include: diversity and cooperative communications in body area networks; ultra wideband radio channel characterisation for body-centric wireless communication; sparse characterisation of body-centric radio channels; antenna / human body interactions in the 60 GHz band; antennas for ingestible capsule telemetry; in vivo wireless channel modelling; diversity and MIMO for efficient front-end design of body-centric wireless communications devices; on-body antennas and radio channels for GPS applications; textile substrate integrated waveguide technology for the next-generation wearable microwave systems; ultra wideband body-centric networks for localisation and motion capture application; down scaling to the nano-scale in body-centric nano-networks; and the road ahead for body-centric wireless communication and networks. .
(source: Nielsen Book Data)9781849199902 20161003
8 p. : digital, PDF file.
<i>Escherichia coli</i> plays an important role as a member of the gut microbiota; however, pathogenic strains also exist, including various diarrheagenic <i>E. coli</i> pathotypes and extraintestinal pathogenic <i>E. coli</i> that cause illness outside of the GI-tract. <i>E. coli</i> have traditionally been serotyped using antisera against the ca. 186 O-antigens and 53 H-flagellar antigens. Phenotypic methods, including bacteriophage typing and O- and H- serotyping for differentiating and characterizing <i>E. coli</i> have been used for many years; however, these methods are generally time consuming and not always accurate. Advances in next generation sequencing technologies have made it possible to develop genetic-based subtyping and molecular serotyping methods for <i>E. coli</i>, which are more discriminatory compared to phenotypic typing methods. Furthermore, whole genome sequencing (WGS) of <i>E. coli</i> is replacing established subtyping methods such as pulsedfield gel electrophoresis, providing a major advancement in the ability to investigate food-borne disease outbreaks and for trace-back to sources. Furthermore, a variety of sequence analysis tools and bioinformatic pipelines are being developed to analyze the vast amount of data generated by WGS and to obtain specific information such as O- and H-group determination and the presence of virulence genes and other genetic markers.
70 p. ; 21 x 30 cm.
Germ cell/heritable mutations are important regulatory endpoints for international agencies interested in protecting the health of future generations. However, germ cell mutation analysis has been hampered by a lack of efficient tools. The motivation for developing this AOP was to provide context for new assays in this field, identify research gaps and facilitate the development of new methods. In this AOP, a compound capable of alkylating DNA is delivered to the testes causing germ cell mutations and subsequent mutations in the offspring of the exposed parents. Although there are some gaps surrounding some mechanistic aspects of this AOP, the overarching AOP is widely accepted and applies broadly to any species that produces sperm.
51 p. ; 21 x 30 cm.
This adverse outcome pathway details the linkage between inhibition of gonadal aromatase activity in females and reproductive dysfunction, as measured through the adverse effect of reduced cumulative fecundity and spawning. Initial development of this AOP draws heavily on evidence collected using repeat-spawning fish species. Cumulative fecundity is the most apical endpoint considered in the OECD 229 Fish Short Term Reproduction Assay. The OECD 229 assay serves as screening assay for endocrine disruption and associated reproductive impairment (OECD 2012). Cumulative fecundity is one of several variables known to be of demographic significance in forecasting fish population trends. Therefore, this AOP has utility in supporting the application of measures of aromatase, or in silico predictions of the ability to inhibit aromatase, as a means to identify chemicals with known potential to adversely affect fish populations and potentially other oviparous vertebrates.