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1 online resource () : illustrations.
  • Processing 2D gel electrophoresis images for efficient Gaussian mixture modeling.- Development of text mining tools for information retrieval from patents.- Multidimensional Feature Selection and Interaction Mining with Decision Tree based ensemble methods.- Study of the Epigenetic Signals in the Human Genome.- An Ensemble Approach for Gene Selection in Gene Expression Data.- Dissimilar Symmetric Word Pairs in the Human Genome.
  • (source: Nielsen Book Data)9783319608150 20170814
Biological and biomedical research are increasingly driven by experimental techniques that challenge our ability to analyse, process and extract meaningful knowledge from the underlying data. The impressive capabilities of next-generation sequencing technologies, together with novel and constantly evolving, distinct types of omics data technologies, have created an increasingly complex set of challenges for the growing fields of Bioinformatics and Computational Biology. The analysis of the datasets produced and their integration call for new algorithms and approaches from fields such as Databases, Statistics, Data Mining, Machine Learning, Optimization, Computer Science and Artificial Intelligence. Clearly, Biology is more and more a science of information and requires tools from the computational sciences. In the last few years, we have seen the rise of a new generation of interdisciplinary scientists with a strong background in the biological and computational sciences. In this context, the interaction of researchers from different scientific fields is, more than ever, of foremost importance in boosting the research efforts in the field and contributing to the education of a new generation of Bioinformatics scientists. The PACBB'17 conference was intended to contribute to this effort and promote this fruitful interaction, with a technical program that included 39 papers spanning many different sub-fields in Bioinformatics and Computational Biology. Further, the conference promoted the interaction of scientists from diverse research groups and with a distinct background (computer scientists, mathematicians, biologists).
(source: Nielsen Book Data)9783319608150 20170814
EBSCOhost Access limited to 1 user
1 online resource (70 p.) : digital, PDF file.
This report is an update to the 2013 report and provides a status of the markets and technology development involved in growing a domestic bioenergy economy as it existed at the end of 2015. It compiles and integrates information to provide a snapshot of the current state and historical trends influencing the development of bioenergy markets. This version features details on the two major bioenergy markets: biofuels and biopower and an overview of bioproducts that enable bioenergy production. The information is intended for policy-makers as well as technology developers and investors tracking bioenergy developments. It also highlights some of the key energy and regulatory drivers of bioenergy markets.
1 online resource ( x, 342 pages) : illustrations (some color).
  • 1.Physico-chemical boundaries of life.- 2.Microbial diversity in deep hypersaline anoxic basins.- 3.Microbial speciation in the geothermal ecosystem.- 4.Bacterial adaptation to hot and dry deserts.- 5.Extremophiles in Antarctica: Life at low temperatures.- 6.Anhydrobiotic rock-inhabiting cyanobacteria: Potential for astrobiology and biotechnology.- 7.Psychrophilic microorganisms as important source for biotechnological processes.- 8.Halophilic microorganisms from man-made and natural hypersaline environments: Physiology, ecology, and biotechnological potential.- 9.Applications of extremophiles in astrobiology: Habitability and life detection strategies.- 10.Extremophiles in spacecraft assembly clean rooms.- 11.The Extreme Biology of Meteorites: Their Role in Understanding the Origin and Distribution of Life on Earth and in the Universe.
  • (source: Nielsen Book Data)9783319483252 20170502
This entirely updated second edition provides an overview on the biology, ecology and biodiversity of extremophiles. Unusual and less explored ecosystems inhabited by extremophiles such as marine hypersaline deeps, extreme cold, desert sands, and man-made clean rooms for spacecraft assembly are presented. An additional focus is put on the role of these highly specialized microorganism in applied research fields, ranging from biotechnology and nanotechnology to astrobiology. Examples such as novel psychrophilic enzymes, compounds from halophiles, and detection strategies for potential extraterrestrial life forms are discussed in detail. The book addresses researchers and advanced students in the fields of microbiology, microbial ecology and biotechnology.
(source: Nielsen Book Data)9783319483252 20170502
EBSCOhost Access limited to 1 user
1 online resource (xii, 404 pages.) :.
The book presents recent developments and application of fluorescent protein-labelling techniques and two-photon molecular probes. It introduces research of super-resolution localization microscopy, photoacoustic molecular (functional) imaging, and optical molecular tomography for small animal in vivo. The book illustrates optical labeling techniques and imaging instruments and their application in biological studies.
(source: Nielsen Book Data)9783110304381 20170814
The invention relates to virus-like particles of bacteriophage MS2 (MS2 VLPs) displaying peptide epitopes or peptide mimics of epitopes of Nipah Virus envelope glycoprotein that elicit an immune response against Nipah Virus upon vaccination of humans or animals. Affinity selection on Nipah Virus-neutralizing monoclonal antibodies using random sequence peptide libraries on MS2 VLPs selected peptides with sequence similarity to peptide sequences found within the envelope glycoprotein of Nipah itself, thus identifying the epitopes the antibodies recognize. The selected peptide sequences themselves are not necessarily identical in all respects to a sequence within Nipah Virus glycoprotein, and therefore may be referred to as epitope mimics VLPs displaying these epitope mimics can serve as vaccine. On the other hand, display of the corresponding wild-type sequence derived from Nipah Virus and corresponding to the epitope mapped by affinity selection, may also be used as a vaccine.
A method for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method comprises attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to the antigens in the array to form immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, to form an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.
A subject afflicted with a cancer or precancerous condition is treated by administering an agent that increases expression of somatostatin receptors, and a cytotoxic recognition ligand. In an alternative embodiment, somatostatin analogs, which are radiolabeled are used to treat cancer or precancerous conditions.
1 online resource (Article No. 13972 ): digital, PDF file.
Photosynthesis uses a limited range of the solar spectrum, so enhancing spectral coverage could improve the efficiency of light capture. Here, we show that a hybrid reaction centre (RC)/yellow fluorescent protein (YFP) complex accelerates photosynthetic growth in the bacterium <i>Rhodobacter sphaeroides</i>. The structure of the RC/YFP-light-harvesting 1 (LH1) complex shows the position of YFP attachment to the RC-H subunit, on the cytoplasmic side of the RC complex. Fluorescence lifetime microscopy of whole cells and ultrafast transient absorption spectroscopy of purified RC/YFP complexes show that the YFP–RC intermolecular distance and spectral overlap between the emission of YFP and the visible-region (Q<sub>X</sub>) absorption bands of the RC allow energy transfer via a Fo¨rster mechanism, with an efficiency of 40±10%. Finally, this proof-of-principle study demonstrates the feasibility of increasing spectral coverage for harvesting light using non-native genetically-encoded light-absorbers, thereby augmenting energy transfer and trapping in photosynthesis.
1 online resource ( viii, 288 pages) : illustrations (some color).
  • ForewordLidia Mariana Fiuza, Ricardo Polanczyk and Neil Crickmore (Editors of the book)PrefaceLeon RabinovitchChapter 1. Bacillus thuringiensis characterization: morphology, physiology, biochemistry, pathotype, cellular and molecular aspectsLeon Rabinovitch, Vilmar Machado, Neiva Knaak, Diouneia Lisiane Berlitz, Ricardo Polanczyk and Lidia Mariana Fiuza Chapter 2. The biology, ecology and taxonomy of Bacillus thuringiensis and related bacteriaBen Raymond Chapter 3. Bacillus thuringiensis toxin classificationNeil Crickmore Chapter 4. Insecticidal proteins from Bacillus thuringiensis and their mechanism of action Alejandra Bravo, Sabino Pacheco, Isabel Gomez, Blanca Garcia-Gomez, Janette Onofre and Mario Soberon Chapter 5. Effect of Bacillus thuringiensis on parasitoids and predatorsSergio Antonio De Bortoli, Alessandra Marieli Vacari, Ricardo Antonio Polanczyk, Ana Carolina Pires Veiga and Roberto Marchi Goulart Chapter 6. Characterization of Bacillus thuringiensis using plasmid patterns, AFLP and rep-PCRFernando Hercos Valicente and Rosane Bezerra da Silva Chapter 7. New sequencing technologies and genomic analysis applied to Bacillus thuringiensisRoberto Franco Teixeira Correia, Anne Caroline Mascarenhas dos Santos, Raimundo Wagner de Souza Aguiar, Bergmann Morais Ribeiro and Fernando Lucas Melo Chapter 8. Expression of Bacillus thuringiensis in insect cellsBergmann Morais Ribeiro, Erica Soares Martins, Raimundo Wagner de Souza Aguiar and Roberto Franco Teixeira Correia Chapter 9. Bacillus thuringiensis: Different Targets and InteractionsLidia Mariana Fiuza, Diouneia Lisiane Berlitz, Jaime Vargas de Oliveira and Neiva Knaak Chapter 10. Specificity and cross-order activity of Bacillus thuringiensis pesticidal proteinsKees van Frankenhuyzen Chapter 11. The American Bacillus thuringiensis based biopesticides market Ricardo Antonio Polanczyk, Kees van Frankenhuyzen and Giuliano Pauli Chapter 12. Mass production, application, and market development of Bacillus thuringiensis Biopesticides in China Lin Li, Zhenmin Chen and Ziniu Yu Chapter 13. The role of Embrapa in the development of tools to control biological pests: a case of successRose Gomes Monnerat, Glaucia de Figueiredo Nachtigal, Ivan Cruz, Wagner Bettiol and Clara Beatriz Hoffman Campo Chapter 14. Bacillus entomopathogenic based biopesticides in vector control programs in BrazilClara Fatima Gomes Cavados, Wanderli Pedro Tadei, Rosemary Aparecida Roque, Leda Narcisa Regis, Claudia Maria Fontes de Oliveira, Helio Benites Gil and Carlos Jose Pereira da Cunha de Araujo-Coutinho Chapter 15. Resistance of mosquitoes to entomopathogenic bacterial based larvicides: current status and strategies for management Maria Helena Neves Lobo Silva-Filha Chapter 16. The importance of Bacillus thuringiensis in the context of genetically modified plants in Brazil Deise Maria Fontana Capalbo and Marise Tanaka Suzuki Chapter 17.Resistance of Spodoptera frugiperda to Bacillus thuringiensis proteins in in the Western Hemisphere Samuel Martinelli, Renato Assis de Carvalho, Patrick Marques Dourado and Graham Phillip Headâ .
  • (source: Nielsen Book Data)9783319566771 20170814
This volume presents a comprehensive perspective of the biopesticides Bacillus thuringiensis and Lysinibacillus sphaericus, from their basic biology to agriculture, forestry and public-health applications. It covers their ecology, virulence factors, and genetic characterization. The topics related to agriculture and forestry include mode of action, receptors of insect pests, and heterologous expression of toxins in insect cells and plants. Public-health researchers will find information on vector control programs with an emphasis on the Neotropical region. The book also discusses new products and the global market.
(source: Nielsen Book Data)9783319566771 20170814
EBSCOhost Access limited to 1 user
The present invention relates to methods and compositions for increasing production of methyl ketones in a genetically modified host cell that overproduces .beta.-ketoacyl-CoAs through a re-engineered .beta.-oxidation pathway and overexpresses FadM.
1 online resource (701 p.) : ill. (some col.)
"All coordination between cells, organs, and organisms depends on successful biocommunicative processes. There are abundant cases of communication in the biological world, both within (intraspecific) and between (interspecific) single-cell and multicellular microorganisms and higher animal forms. Split into two parts, this book first looks at the history, development and progress within the field of biocommunication. The second part presents real-life case studies and investigation into examples of biocommunication in the biological world. Among the organisms covered are bacteria, fungi, plants, terrestrial and marine animals, including bonobos, chimpanzees and dolphins, as well as a new theory of communication between parts in developing embryos (cybernetic embryos). Contributions from international experts in the field provide up-to-date research and results, while in depth analysis expands on these findings to pave the way for future discoveries. As the first comprehensive review of its kind, it is perfect for undergraduates, graduates, professionals and researchers in the field of life sciences."--Publisher's website.
1 online resource ( xiv, 366 pages) : illustrations (some color).
  • Foreword; Preface; Acknowledgments; Contents of Volume 1; Contents of Volume 2; Part I: Biological Invasions in China: Outline; Chapter 1: Biological Invasion and Its Research in China: An Overview; 1.1 Introduction; 1.2 A Glance at IAS Occurrence and Damage in China; 1.3 What Have Been Studied Mostly; 1.3.1 Research Attention to Various Kinds of Ecosystems and IAS; 1.3.2 Major Research Topics; 1.4 What Achievements We Already Had; 1.4.1 Current Status and Biological Background of IAS; 1.4.2 Novel Invasion Mechanisms; 1.4.3 Ecosystem Invasibility; 1.4.4 Risk Assessment and Early Warning
  • 1.4.5 Detection and Monitoring1.4.6 Early Prevention and Efficient Interception; 1.4.7 Sustainable Control Methods; 1.4.8 Database of Invasive Alien Species; 1.4.9 Education to the Public; 1.4.10 Framework of Biological-Invasion Research and Management; 1.4.11 Contributions to National Policy Making; 1.5 Government's Role; 1.6 International Cooperation; 1.7 About This Book; 1.7.1 Why We Want to Publish This Book; 1.7.2 What Are in This Book; 1.8 Conclusions; References; Chapter 2: Biological Invasions in Agricultural Ecosystems in China; 2.1 Introduction
  • 2.2 Historical and Current Status of Biological Invasions in China Agroecosystem2.2.1 Diversity and Source of IAS; 2.2.2 Geographic Distribution and Spread of IAS; 2.2.3 Damage; 2.3 Invasibility of China Agroecosystems; 2.4 Invasiveness and Underlying Invasion Mechanisms of IAS in China; 2.4.1 Adaptation to Physical Stresses; 2.4.2 Allelopathic Effects; 2.4.3 Phenotypic Plasticity; 2.4.4 Natural Enemy Release and Corresponding Changes in Growth and Defence Characters; 2.4.5 Energy-Use Capacity and Strategy; 2.4.6 Associations with Microbial Community; 2.4.7 Clonal Integration
  • 2.5 Management of IAS in China Agroecosystems2.5.1 Risk Analysis; 2.5.2 Detection and Monitoring; 2.5.3 Regional Prevention; 2.5.4 Biological Control; 2.5.5 Replacement of Invasive Plants; 2.5.6 Breeding and Use of Resistant Crop Cultivars; 2.5.7 Integrated Use of Invasive Plants; 2.6 Conclusion and Future Perspectives; References; Chapter 3: Biological Invasions in Forest Ecosystem in China; 3.1 Introduction; 3.2 Several Forest Invasive Species in China; 3.2.1 Fall Webworm Hyphantria cunea (Drury); 3.2.2 Sirex Woodwasp Sirex noctilio F.
  • 3.2.3 Blue Gum Chalcid Leptocybe invasa Fisher & La Salle3.2.4 Loblolly Pine Mealybug Oracella acuta (Lobdell); 3.3 Basic Theoretical Research on Biological Invasions in Forest Ecosystem in China; 3.3.1 Multi-species Synergy in Biological Invasions; 3.3.2 Microevolution in Invasive Species; 3.4 Strategies and Policies for Management of Forest Pest Invasions; 3.5 Conclusion and Perspectives; References; Chapter 4: Biological Invasions in Aquatic Ecosystems in China; 4.1 Introduction; 4.2 Non-native Species and Their Distributions in Aquatic Ecosystems; 4.2.1 Aquatic Non-native Species
ProQuest Ebook Central Access limited to 1 user
1 online resource (61 p.) : digital, PDF file.
U.S. military influenza surveillance uses electronic reporting of clinical diagnoses to monitor health of military personnel and detect naturally occurring and bioterrorism-related epidemics. While accurate, these systems lack in timeliness. More recently, researchers have used novel data sources to detect influenza in real time and capture nontraditional populations. With data-mining techniques, military social media users are identified and influenza-related discourse is integrated along with medical data into a comprehensive disease model. By leveraging heterogeneous data streams and developing dashboard biosurveillance analytics, the researchers hope to increase the speed at which outbreaks are detected and provide accurate disease forecasting among military personnel.
1 online resource.
  • Acknowledgments; Contents; About the Editors; Chapter 1: Introduction; 1.1 The Decline of Biodiversity in the Agro-ecosystems; 1.2 Differences Between Western and Eastern Europe Agriculture
  • The Role of History; 1.3 Conservation Tools: From the Protected Areas Approach and Nature2000 Network to the High Nature Value Areas in Europe; 1.3.1 A Concept of Protected Areas Application to Successful Conservation; 1.3.2 Theories for Fragmented Space; 1.3.3 Applying Ecological Terminology for Agricultural Landscapes of Whole Europe?; 1.4 HNV Farming Definition
  • 1.5 Approaches to Characterize HNV Farming1.5.1 Land Cover Approach; 1.5.2 Farm System Approach; 1.5.3 Species Approach; 1.6 The HNV as Support for Biodiversity and Public Goods; 1.7 This Book in Few Words; References; Chapter 2: Spread of the Concept of HNV Farmland in Europe: A Systematic Review; 2.1 Introduction; 2.2 Methods; 2.3 Results; 2.4 Discussion; Bibliography; Chapter 3: Identifying HNV Areas Using Geographic Information Systems and Landscape Metrics; 3.1 Introduction; 3.2 Simple Metrics for Identification of HNV Farmland; 3.3 Input Data for Calculation of Landscape Metrics
  • 3.4 Landscape Metrics Case Study: An Example of Using Landscape Metrics to Identify HNV FarmlandReferences; Chapter 4: Suitable Methods for Monitoring HNV Farmland Using Bird Species; 4.1 Bird Count Methods for Farmland Systems: Single-Habitat and Multi-habitat Species; 4.2 The Concept of Bioindicators or Environmental Surrogates and Common Measures of Diversity in Bird Communities; 4.2.1 The Concept of Bioindicators; 4.2.2 Common Diversity Metrics Useful for Bird Communities; 4.3 Species Distribution Models and Other Useful Statistical Tools; 4.3.1 SDMs in a Nutshell; 4.4 Other Useful Tools
  • 4.4.1 MRT-Multiregression Tree Analysis4.4.2 Indicator Species Analysis; References; Part I: Case Studies; Chapter 5: Case Study 1. Bird as Indicators of HNV: Case Study in Farmlands from Central Italy; 5.1 Methodology; 5.1.1 Study Area; 5.1.2 Species and Environmental Data; 5.1.3 Data Analysis; 5.2 Results; 5.2.1 Farmland Classification and Description; 5.2.2 Bird Indicators of HNV Farmland; 5.2.3 Relative Importance of HNV Farmland Characteristics for Bird Distribution; 5.3 Discussion; 5.3.1 Utility of the Proposed Methodology; References
  • Chapter 6: Case Study 2. Birds as Indicators of HNV: Case Study in Portuguese Cork Oak Montados6.1 Methodology; 6.1.1 Study Area; 6.1.2 Bird Census; 6.1.3 HNV Features and Explanatory Variables; 6.1.4 Data Analysis; 6.2 Results; 6.2.1 Environmental Variables; 6.2.2 Bird Guilds; 6.2.3 Modelling of Bird Guilds; 6.3 Discussion; 6.4 Conclusion; References; Chapter 7: Case Study 3. Using Indicator Species AnalysisIndVal to Identify Bird Indicators of HNV in Farmlands from Western P...; 7.1 Methodology; 7.1.1 Study Area; 7.1.2 Species and Environmental Data; 7.1.3 Data Analysis; 7.2 Results
EBSCOhost Access limited to 1 user
1 online resource (1 streaming video file (27 min.) : color, sound).
  • Contents: The phenomenon of ageing
  • Introducing Caenorhabditis elegans
  • C. elegans biology and ageing: features and advantages
  • Key discoveries and milestones
  • An example: mitochondrial turnover and ageing.
The present invention relates to variants of a parent cellobiohydrolase II. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
1 online resource (Article No. 41121 ): digital, PDF file.
N-Acylethanolamines (NAEs) are a group of fatty acid amides that play signaling roles in diverse physiological processes in eukaryotes. We used fatty acid amide hydrolase (FAAH) degrades NAE into ethanolamine and free fatty acid to terminate its signaling function. In animals, chemical inhibitors of FAAH for therapeutic treatment of pain and as tools to probe deeper into biochemical properties of FAAH. In a chemical genetic screen for small molecules that dampened the inhibitory effect of N-lauroylethanolamine (NAE 12:0) on Arabidopsis thaliana seedling growth, we identified 6-(2-methoxyphenyl)-1,3-dimethyl-5-phenyl-1H-pyrrolo[3,4-d]pyrim idine-2,4(3 H, 6 H)-dione (or MDPD). MDPD alleviated the growth inhibitory effects of NAE 12:0, in part by enhancing the enzymatic activity of Arabidopsis FAAH (AtFAAH). In vitro, biochemical assays showed that MDPD enhanced the apparent Vmax of AtFAAH but did not alter the affinity of AtFAAH for its NAE substrates. Furthermore, structural analogs of MDPD did not affect AtFAAH activity or dampen the inhibitory effect of NAE 12:0 on seedling growth indicating that MDPD is a specific synthetic chemical activator of AtFAAH. Our study demonstrates the feasibility of using an unbiased chemical genetic approach to identify new pharmacological tools for manipulating FAAH- and NAE-mediated physiological processes in plants.
48 p.
The purpose of this working paper is to review existing chemical risk assessment methods in the context of supporting socio-economic cost-benefit analysis, focusing on more “typical” risk assessments that may not have strong epidemiologic data and/or were not originally designed to support socio-economic analyses. A number of case studies of such “typical” chemical risk assessments were reviewed with respect to their suitability for supporting socio-economic analyses.
Methods for preparing an antibody are provided with the method including incorporating 3-bromo-4-hydroxy-benzoic acid into a protein to form an antigen, immunizing a mammalian host with the antigen, and recovering an antibody having an affinity for the antigen from the host. Antibodies having a binding affinity for a monohalotyrosine are provided as well as composition comprising an antibody bound with monohalotyrosine. Compositions comprising a protein having a 3-bromo-4-hydroxy-benzoic acid moiety are also provided. Methods for evaluating the severity of asthma are provide with the methods including analyzing sputum of a patient using an antibody having a binding affinity for monohalotyrosine, and measuring the amount of antibody bound to protein. Methods for determining eosinophil activity in bodily fluid are also provided with the methods including exposing bodily fluid to an antibody having a binding affinity for monohalotyrosine, and measuring the amount of bound antibody to determine the eosinophil activity.
The present invention relates to enzyme compositions for high temperature saccharification of cellulosic material and to uses thereof.