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Book
1 online resource () : color illustrations.
Book
1 online resource (xvii, 645 pages) : illustrations (chiefly color).
  • An introduction to the disease. Alzheimer’s disease therapy: present and future molecules / Awanish Kumar, Ashwini Kumar
  • Computational modeling methods for anti-Alzheimer agents. Recent advances in computational approaches for designing potential anti-Alzheimer’s agents / Sergi Gómez-Ganau, Jesús Vicente de Julián-Ortiz, Rafael Gozalbes
  • Computer-aided drug design approaches to study key therapeutic targets in Alzheimer’s disease / Agostinho Lemos, Rita Melo, Irina S. Moreira, M. Natália D. S. Cordeiro
  • Virtual screening in the search of new and potent anti-Alzheimer agents / Livia Basile
  • Molecular field topology analysis (MFTA) in the design of neuroprotective compounds / Eugene V. Radchenko, Vladimir A. Palyulin, Nikolay S. Zefirov
  • Modeling of ligands acting against specific anti-Alzheimer drug targets. Galantamine derivatives as acetylcholinesterase inhibitors: docking, design, synthesis, and inhibitory activity / Irini Doytchinova, Mariyana Atanasova, Georgi Stavrakov, Irena Philipova, Dimitrina Zheleva-Dimitrova
  • Modeling of BACE-1 inhibitors as anti-Alzheimer’s agents / Odailson Santos Paz, Thamires Quadros Froes, Franco Henrique Leite, Marcelo Santos Castilho
  • Design of anti-Alzheimer’s disease agents focusing on a specific interaction with target biomolecules / Yoshio Hamada, Kenji Usui
  • Molecular docking and molecular dynamics simulation to evaluate compounds that avoid the amyloid beta aggregation / Maricarmen Hernández Rodríguez, Leticia Guadalupe Fragoso Morales, José Correa Basurto, Martha Cecilia Rosales Hernández
  • In silico strategies to design small molecules to study beta-amyloid aggregation / Praveen P. N. Rao, Deguo Du
  • Computational approaches to understand cleavage mechanism of amyloid beta (A[beta]) peptide / Kailas Dashrath Sonawane, Maruti Jayaram Dhanavade
  • Computational modeling of gamma-secretase inhibitors as anti-Alzheimer agents / Prabu Manoharan, Nanda Ghoshal
  • Molecular modeling of tau proline-directed protein kinase (PDPK) inhibitors / Carlos Navarro-Retamal, Julio Caballero
  • Computational modelling of kinase inhibitors as anti-Alzheimer agents / Mange Ram Yadav, Mahesh A. Barmade, Rupesh V. Chikhale, Prashant R. Murumkar
  • Computational modeling of drugs for Alzheimer’s disease: design of serotonin 5-HT6 antagonists / Ádám A. Kelemen, Stefan Mordalski, Andrzej J. Bojarski, György M. Keserű
  • Computational modeling of diagnostic imaging agents for Alzheimer’s disease: molecular imaging agents for the in vivo detection of amyloid plaques in Alzheimer’s disease / Dionysia Papagiannopoulou, Dimitra Hadjipavlou-Litina
  • Special topics. Computational approaches for therapeutic application of natural products in Alzheimer’s disease / Manika Awasthi, Swati Singh, Sameeksha Tiwari, Veda P. Pandey, Upendra N. Dwivedi
  • In silico studies applied to natural products with potential activity against Alzheimer’s disease / Luciana Scotti, Marcus T. Scotti
  • Computational modeling of multi-target-directed inhibitors against Alzheimer’s disease / Akhil Kumar, Ashok Sharma
  • Neuropharmacology in flux: molecular modeling tools for understanding protein conformational shifts in Alzheimer’s disease and related disorders / Gerald H. Lushington, Frances E. S. Parker, Thomas H. W. Lushington, Nora M. Wallace
  • Computational nanotechnology: a tool for screening therapeutic nanomaterials against Alzheimer’s disease / R. Navanietha Krishnaraj, Dipayan Samanta, Rajesh K. Sani.
"This volume describes different computational methods encompassing ligand-based approaches (QSAR, pharmcophore), structure-based approaches (homology modeling, docking, molecular dynamics simulation), and combined approaches (virtual screening) with applications in anti-Alzheimer drug design. Different background topics like molecular etiologies of Alzheimer’s disease, targets for new drug development, and different cheminformatic modeling strategies are covered for completeness. Special topics like multi-target drug development, natural products, protein misfolding, and nanomaterials are also included in connection with computational modeling of anti-Alzheimer drug development. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Computational Modeling of Drugs Against Alzheimer’s Disease is a valuable resource for learning about the latest computational techniques used to study this disease"--Publisher's description.
Book
1 online resource.
  • Introduction. Biosecurity and Risk Management. Economics of Invasive Species Damage and Damage Management. Policy and Regulation. Ecological Issues. Feeding a Hungry World: Threats to Agriculture by Invasive Vertebrate Species in the United States. Brown Tree Snakes: Methods and Approaches for Control. Burmese Pythons. Frogs (Coqui Frogs, Greenhouse Frogs, Cuban Tree Frogs, and Cane Toads). Ecology, Impacts, and Management of Invasive Rodents in the United States. Wild Pigs. Ecology of the Small Indian Mongoose (Herpestes auropunctatus) in North America. Feral Cats. Feral Goats and Sheep. European Starlings. Monk and Rose-Ringed Parakeets. Introduction History, Impacts, and Management of House Sparrows in North America. Conclusions, Challenges, and Research Needs.
  • (source: Nielsen Book Data)9781498704847 20171211
Vertebrate invasive species are important ecologically, socially, and scientifically throughout much of the globe. However, the interdiction and options for management of invasive species are driven by localized regulation at the country or even state level and thus the management of species must be framed within that context. This book is focused around the management of invasive vertebrate species in the United States, although readers will find much of the material broadly applicable to invasive species in other regions. Vertebrate invasive species cause damage to agriculture, property, natural resources, and threaten human health and safety. However, most of these species occur in the United States resulting from human-mediated activities, often being released intentionally. For the first time, the wealth of scientific information about vertebrate invasive species in the United States is summarized and synthesized in a single volume to be easily accessible to ecologists and natural resource managers. With a focus on prominent terrestrial invasive species that have a history of policy and management and highlighting contemporary issues and management, this book consists of 18 chapters written by experts from across the United States. The first section of the book focuses on overarching policy and management topics associated with vertebrate invasive species; including biosecurity threats and risk assessment, policy and regulation, and the economics of their management. The second section provides in-depth reviews of noteworthy invasive mammals, birds, amphibians, and reptiles. After finishing this book, the reader should understand the complexity of managing invasive species, the unique challenges that each new species may present, and the steps forward that may decrease the impact of these species on the environment, human health, and the economy.
(source: Nielsen Book Data)9781498704847 20171211
Book
1 online resource.
  • REPRODUCIBILITY, BIAS, AND OBJECTIVITY IN CONSERVATION SCIENCE-- CHALLENGES TO FOUNDATIONAL PREMISES IN CONSERVATION-- ICONIC CONSERVATION TALES: SORTING TRUTH FROM FICTION-- QUESTIONING ACCEPTED STRATEGIES AND INTERVENTIONS-- CONCLUSION.
  • (source: Nielsen Book Data)9780198808978 20180115
This edited volume assembles some of the most intriguing voices in modern conservation biology. Collectively they highlight many of the most challenging questions being asked in conservation science today, each of which will benefit from new experiments, new data, and new analyses. The book's principal aim is to inspire readers to tackle these uncomfortable issues head-on. A second goal is to be reflective and consider how the field has reacted to challenges, and to what extent these challenges advance conservation science. A concluding chapter will synthesize common themes that emerge from the experiences of the authors in these debates and discuss how best to guard against confirmation bias. The hope is that this book will lead to greater conservation of ecosystems and biodiversity by harnessing the engine of constructive scientific scepticism in service of better results.
(source: Nielsen Book Data)9780198808978 20180115
EBSCOhost Access limited to 1 user
Book
1 online resource : illustrations.
  • PART I - CHROMATIN ORGANIZATION AND DYNAMICS 1. DNA mechanics 2. DNA supercoiling (omics) 3. Chromatin and chromosome folding (experiments) 4. Chromatin and chromosome folding (modeling) 5. Chromatin and chromosome physics 6. ncRNA in chromatin folding 7. Insulators 8. Condensins and cohesins 9. Long range interactions 10. Crowding PART II - NUCLEAR ENVELOPE, NUCLEAR BODIES AND NUCLEOCYTOPLASMIC TRAFFICKING 11. Nuclear bodies 12. Nucleolus 13. Transcription factories 14. Polycomb bodies 15. Nuclear lamina 16. Other components of the nucleoskeleton 17. Nuclear pores 18. Nuclear traffic PART III - MAIN NUCLEAR FUNCTIONS 19. Chromatin folding and DNA replication 20. Chromatin folding and DNA repair 21. Chromatin folding and transcription 22. Chromatin folding and recombination 23. Chromatin folding and differentiation 24. Nuclear mechanics and mechanotransduction 25. Altered nucleus and disease PART IV - SPECIFIC FEATURES OF NUCLEAR ORGANIZATION IN MAIN MODEL ORGANISMS 26. Yeast nucleus 27. Nematode nucleus 28. Drosophila nucleus 29. Plant nucleus Conclusion and perspectives by the editors.
  • (source: Nielsen Book Data)9780128034804 20171211
Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines.
(source: Nielsen Book Data)9780128034804 20171211
Book
1 online resource (381 p.) : ill. (some col.)
"All sorts of biological activities are processed thermodynamically, and at the utmost fundamental level, the laws of biology must be thermodynamics. However, the current laws of thermodynamics are unable to give reasonable explanation of biological processes. In order to do so, irreversible thermodynamics has been theorized to describe the basic mechanism for the origin of natural order or the development of things (related to developmental biology). The scientific definition of the system theory concept has been obtained and the properties of a biological system can be analyzed by applying principles of it. Irreversible thermodynamics and system theory act as the theoretical foundation for theoretical biology. By applying principles of irreversible thermodynamics and system theory, the axiomatic theory of biology has been developed."--Publisher's website.
Software/Multimedia
1 online resource (649 p.) : ill. (chiefly col.)
"The Pacific Symposium on Biocomputing (PSB) 2018 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2018 will be held on January 3 – 7, 2018 in Kohala Coast, Hawaii. PSB 2018 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field."--Publisher's website.
Book
1 online resource.
  • INTRODUCTION BY THE EDITORS. Introducing the New Biosocial Landscape-- Meloni, Cromby, Fitzgerald, and Lloyd.- SECTION I: History of the Biology/Society Relationship.- Chapter 1.Models, Metaphors, Lamarckisms and the Emergence of `Scientific Sociology'-- Snait Gissis.- Chapter 2.The transcendence of the social: Durkheim, Weismann and the Purification of Sociology-- Maurizio Meloni.- Chapter 3. Biology, Social Science, and Population in Late Nineteenth- and Early Twentieth-Century Britain-- Chris Renwick.- Chapter 4. The concept of plasticity in the history of the nature-nurture debate in the early 20th century-- Antonine Nicoglou.- Chapter 5. An Evolving, Evolutionary Science of Human Differences-- Jonathan Marks.- Chapter 6. Experimenting in the Biosocial: The Strange Case of Twin Research-- Will Viney.- Chapter 7. Histories and meanings of Epigenetics-- Tatjana Buklijas.- SECTION II. Genomics, Postgenomics, Epigenetics and Society.- Chapter 8. Scrutinizing the Epigenetics Revolution-- Maurizio Meloni and Giuseppe Testa, .- Chapter 9. Social & Behavioral Epigenetics: Evolving Perspectives on Nature-Nurture Interplay, Plasticity, and Inheritance-- Frances Champagne.- Chapter 10. Molecular Multicultures-- Amy Hinterberger.- Chapter 11. The First Thousand Days: Epigenetics in the Age of Global Health-- Michelle Pentecost.- Chapter 12. Genetics, epigenetics and social justice in education: learning as a complex biosocial phenomenon-- Deborah Youdell.- Chapter 13. Genetics, epigenetics and social justice in education: learning as a complex biosocial phenomenon-- Sabina Leonelli.- SECTION III. Neuroscience: brain, culture and social relations.- Chapter 14. Proposal for a Critical Neuroscience-- Jan Slaby and Suparna Choudhury.- Chapter 15. On the Neurodisciplines of Culture-- Fernando Vidal and Francisco Ortega.- Chapter 16. Affective Neuroscience as Sociological Inquiry?-- - Christian Von Scheve.- Chapter 17. Mechanisms of Embodiment in Religious Belief and Practice: "Bio-looping" in Candomble Trance and Possession-- Rebecca Seligman.- Chapter 18. Experimental Entanglements: Social Science and Neuroscience beyond Interdisciplinarity-- Des Fitzgerald and Felicity Callard.- Chapter 19 Developing Schizophrenia-- John Cromby.- Chapter 20. Epigenetics and the suicidal brain: reconsidering context in an emergent style of reasoning-- Stephanie Lloyd and Eugene Raikhel.- SECTION IV. Social Epidemiology.- Chapter 21. The embodiment dynamic over the lifecourse: a case for examining cancer aetiology-- Michelle Kelly-Irving & Cyrille Delpierre.- Chapter 22. Epigenetic signatures of socioeconomic status across the lifecourse-- Silvia Stringhini and Paolo Vineis.- Chapter 23. An intergenerational perspective on social inequality in health and life opportunities: the maternal capital model-- Jonathan Wells and Akanksha Marphatia.- Chapter 24. Quantifying social influences throughout the life-course: action, structure and `omics'-- Mike Kelly and Rachel Kelly.- Chapter 25 Health inequalities and the interplay of socioeconomic factors and health in the life course-- Rasmus Hoffmann, Hannes Kroger, Eduwin Pakpahan.- SECTION V. Medicine and Society.- Chapter 26. Universal Biology, Local Society? Notes from Anthropology-- Patrick Bieler, Jorg Niewohner.- Chapter 27.Big Data and Biomedicine-- Nadine Levin.- Chapter 28. Personalised and Precision Medicine: What kind of society does it take?-- Barbara Prainsack.- Chapter 29. Emergent postgenomic bodies and their (non)scalable environments-- Megan Warin and Aryn Martin.- Chapter 30. The vitality of disease-- Ayo Wahlberg.- Chapter 31. Bioethnography: A How-To Guide for the Twenty-First Century-- Liz Roberts and Camilo Sanz.- SECTION VI.Contested Sites/Future Perspectives.- Chapter 32. The Postgenomic Politics of Race-- Catherine Bliss.- Chapter 33. Of Rats and Women: Narratives of Motherhood in Environmental Epigenetics-- Martha Kenney and Ruth Muller.- Chapter 34. Ancestors and Identities: DNA, Genealogy, and Stories-- Jessica Bardill.- Chapter 35. Species of Biocapital, 2008 and Speciating Biocapital, 2017-- Stefan Helmreich with a postcript by Nicole Labruto.- Chapter 36. Human Tendencies-- Ed Cohen.- Chapter 37. Ten theses on the subject of biology and politics: conceptual, methodological, and biopolitical considerations-- Samantha Frost.
  • (source: Nielsen Book Data)9781137528780 20171211
This comprehensive handbook synthesizes the often-fractured relationship between the study of biology and the study of society. Bringing together a compelling array of interdisciplinary contributions, the authors demonstrate how nuanced attention to both the biological and social sciences opens up novel perspectives upon some of the most significant sociological, anthropological, philosophical and biological questions of our era. The six sections cover topics ranging from genomics and epigenetics, to neuroscience and psychology to social epidemiology and medicine. The authors collaboratively present state-of-the-art research and perspectives in some of the most intriguing areas of what can be called biosocial and biocultural approaches, demonstrating how quickly we are moving beyond the acrimonious debates that characterized the border between biology and society for most of the twentieth century. This landmark volume will be an extremely valuable resource for scholars and practitioners in all areas of the social and biological sciences.The chapter 'Ten Theses on the Subject of Biology and Politics: Conceptual, Methodological, and Biopolitical Considerations' is open access under a CC BY 4.0 license via link.springer.com.Versions of the chapters 'The Transcendence of the Social', 'Scrutinizing the Epigenetics Revolution', 'Species of Biocapital, 2008, and Speciating Biocapital, 2017' and 'Experimental Entanglements: Social Science and Neuroscience Beyond Interdisciplinarity' are available open access via third parties. For further information please see license information in the chapters or on link.springer.com.
(source: Nielsen Book Data)9781137528780 20171211
Book
1 online resource.
  • 1. Fundamentals of protein and cell interactions in biomaterials Part 1 Proteins in biomaterials mimicking the extra cellular matrix 2. Extracellular matrix constitution and function for tissue regeneration and repair 3. Surface functionalization of biomaterials for tissue regeneration and repair 4. Bioengineered peptide biomaterials for tissue regeneration and repair Part 2 Protein-based biomaterials for tissue regeneration and repair 5. Collagen-based biomaterials for tissue regeneration and repair 6. Fibrin-Based Biomaterials for tissue regeneration and repair 7. Fibrous protein-based biomaterials (silk, keratin, elastin and resilin proteins) for tissue regeneration and repair Part 3 Processing of peptides and proteins as biomaterials 8. Fabrication of nanofibres and nanotubes for tissue regeneration and repair 9. Peptide and protein printing for tissue regeneration and repair Part 4 Bioengineering of proteins and peptides 10. Self-assembled peptides for tissue regeneration and repair 11. Collagen-like materials for tissue regeneration and repair 12. Elastin-like materials for tissue regeneration and repair 13. Mussel inspired Biomaterials (bioadhesives) for tissue regeneration and repair Part 5 Antimicrobial peptides (AMP) based biomaterial 14. AMP biomaterial coatings for tissue regeneration and repair 15. AMP as hydrogels for tissue regeneration and repair.
  • (source: Nielsen Book Data)9780081008034 20171204
Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology.
(source: Nielsen Book Data)9780081008034 20171204
Software/Multimedia
1 online resource (153 p.) : ill. (some col.)
"Systems biology combines computational and experimental approaches to analyze complex biological systems and focuses on understanding functional activities from a systems-wide perspective. It provides an iterative process of experimental measurements, data analysis, and computational simulation to model biological behavior. This book provides explained protocols for high-throughput experiments and computational analysis procedures central to cancer systems biology research and education. Readers will learn how to generate and analyze high-throughput data, therapeutic target protein structure modeling and docking simulation for drug discovery. This is the first practical guide for students and scientists who wish to become systems biologists or utilize the approach for cancer research."-- Provided by publisher.
Book
1 online resource.
  • ""Cover""; ""Title Page""; ""Copyright Page""; ""Contents""; ""List of Contributors""; ""Preface""; ""References""; ""Chapter 1
  • Reproducibility in Biomedical Research""; ""1.1
  • Introduction""; ""1.2
  • Defining Reproducibility""; ""1.2.1
  • A New Lexicon for Reproducibility""; ""1.2.1.1
  • Methods Reproducibility""; ""1.2.1.2
  • Results Reproducibility""; ""1.2.1.3
  • Inferential Reproducibility""; ""1.2.1.4
  • Bayesian Paradigms in Reproducibility""; ""1.3
  • Discipline Specific Terminology in the Biomedical Sciences?""
  • ""1.4
  • Experimental Factors in Addition to Statistics That Affect Reproducibility""""1.4.1
  • Unknown Unknowns Affecting Reproducibility""; ""1.4.1.1
  • The Crabbe Mouse Study""; ""1.4.1.2
  • Reproducibility Confounds in RNA Interference""; ""1.4.1.3
  • Caenorhabditis Lifespan""; ""1.4.2
  • Known Unknowns: Tacit Expertize""; ""1.4.3
  • Diminishing Effects: Regression to the Mean""; ""1.4.4
  • Overinterpretation of Effects on Secondary Endpoints in Studies""; ""1.5
  • The Impact of the Internet on the Evolution of Research Practicesâ#x80; #x94; Databases and Third Party Analyses""; ""1.5.1
  • Data Input""
  • ""1.5.2
  • Data Curation""""1.5.3
  • Cross-Database Integration""; ""1.5.4
  • Analytical Tools""; ""1.6
  • The Reproducibility Problem""; ""1.6.1
  • Factors Contributing to the Reproducibility Problem""; ""1.6.2
  • Human Contributions to the Reproducibility Problem""; ""1.6.2.1
  • Litigation in Basic Biomedical Research""; ""1.6.3
  • The Impact of the Internet on Publishing and Disseminating Information""; ""1.6.3.1
  • High and Low Profile Journals""; ""1.7
  • The Literature on Reproducibility in Biomedical Research""; ""1.7.1
  • An Age-Old Concern""; ""1.7.2
  • Concerns in the 21st Century""
  • ""1.7.3
  • Reproducibility in the 21st Century: Origins, Scope and Momentum""""1.7.3.1
  • Why Most Published Research Findings are False""; ""1.7.3.2
  • Believe it or not: How Much can we Rely on Published Data on Potential Drug Targets?""; ""1.7.3.3
  • Drug Development: Raise Standards for Preclinical Cancer Research""; ""1.7.3.4
  • Reproducibility: An Academic Viewpoint""; ""1.7.3.5
  • Reproducibility in the Psychological Sciences""; ""1.7.3.6
  • Researcher Awareness of Fraud""; ""1.8
  • Is There a Reproducibility Crisis?""; ""1.9
  • Trouble at the Laboratory?""; ""1.10
  • Retractions""
  • ""1.10.1
  • RetractionWatch""""1.10.2
  • Continued Citation of Retracted Publications""; ""1.10.3
  • The Spectrum of Irreproducibility""; ""1.10.4
  • Research Misconduct""; ""1.10.5
  • Fraud""; ""1.10.6
  • Notable Examples of Fraudâ#x80; #x94; Biomedical Researchers Behaving Badly""; ""1.10.6.1
  • MMR Vaccine: Andrew Wakefieldâ#x80; #x94; Royal Free Hospital""; ""1.10.6.2
  • Embryonic Stem Cells: Hwang Woo-Sukâ#x80; #x94; Seoul National University""; ""1.10.6.3
  • Environment and Human Behavior: Diederik Stapelâ#x80; #x94; Tilburg University""
  • ""1.10.6.4
  • Stimulus-Triggered Acquisition of Pluripotency (STAP): Haruko Obokataâ#x80; #x94; RIKEN Institute""
Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences.
Software/Multimedia
1 online resource (541 p.) : ill. (some col.)
"This unique story offers an introductory conversation to genetics, embryology and evolution, taking us on a historical journey of biology through the ages. Using a series of dialogues between the Greek philosopher Democritus and his disciple Alkimus, we travel through time visiting eminent scientists throughout the centuries, from Lazzaro Spallanzani and Theodor Boveri to Francis Crick, Max Perutz and Christiane Nüsslein–Volhard. We find ourselves at the intersection of competing theories in biology and witness the progression from the debunking the theory of spontaneous generation to the mapping of the genome. Attention is given not only to the great successes in the field but also to the equally important and exciting failures. Originally published in Hungarian, The Story of Genetics, Development and Evolution provides a historical background to the life sciences, with complex scientific concepts stripped down and explained carefully for academics and anyone interested in going back to the roots and philosophies of scientific progress."-- Provided by publisher.
Book
VIII, 322 p. 40 ill., 34 illus. in color : online resource. Digital: text file; PDF.
  • Promoters and terminator discovery and engineering.- Engineering and Evolution of Saccharomyces cerevisiae to Produce Biofuels and Chemicals.- Corynebacterium glutamicum for Sustainable Bioproduction: From Metabolic Physiology to Systems Metabolic Engineering.- Orthogonal Protein Translation Using Pyrrolysyl-tRNA Synthetases for Single and Multiple-Noncanonical Amino Acid Mutagenesis.- Synthetic Biology for Cell-Free Biosynthesis: Fundamentals of Designing Novel In Vitro Multi-Enzyme Reaction Networks.- Molecular engineering of synthetic metabolic pathways.- Pathway Design, Engineering and Optimization.- Xenobiology: State-of-the-art, Ethics and Philosophy of new-to-nature organisms.
  • (source: Nielsen Book Data)9783319553177 20171211
This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science.Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification.In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
(source: Nielsen Book Data)9783319553177 20171211
Book
1 online resource (p. 676-683) : digital, PDF file.
We present 1,003 reference genomes that were sequenced as part of the Genomic Encyclopedia of Bacteria and Archaea (GEBA) initiative, selected to maximize sequence coverage of phylogenetic space. These genomes double the number of existing type strains and expand their overall phylogenetic diversity by 25%. Comparative analyses with previously available finished and draft genomes reveal a 10.5% increase in novel protein families as a function of phylogenetic diversity. The GEBA genomes recruit 25 million previously unassigned metagenomic proteins from 4,650 samples, improving their phylogenetic and functional interpretation. We identify numerous biosynthetic clusters and experimentally validate a divergent phenazine cluster with potential new chemical structure and antimicrobial activity. This Resource is the largest single release of reference genomes to date. Bacterial and archaeal isolate sequence space is still far from saturated, and future endeavors in this direction will continue to be a valuable resource for scientific discovery.
Book
1 online resource () : illustrations.
  • Processing 2D gel electrophoresis images for efficient Gaussian mixture modeling.- Development of text mining tools for information retrieval from patents.- Multidimensional Feature Selection and Interaction Mining with Decision Tree based ensemble methods.- Study of the Epigenetic Signals in the Human Genome.- An Ensemble Approach for Gene Selection in Gene Expression Data.- Dissimilar Symmetric Word Pairs in the Human Genome.
  • (source: Nielsen Book Data)9783319608150 20170814
Biological and biomedical research are increasingly driven by experimental techniques that challenge our ability to analyse, process and extract meaningful knowledge from the underlying data. The impressive capabilities of next-generation sequencing technologies, together with novel and constantly evolving, distinct types of omics data technologies, have created an increasingly complex set of challenges for the growing fields of Bioinformatics and Computational Biology. The analysis of the datasets produced and their integration call for new algorithms and approaches from fields such as Databases, Statistics, Data Mining, Machine Learning, Optimization, Computer Science and Artificial Intelligence. Clearly, Biology is more and more a science of information and requires tools from the computational sciences. In the last few years, we have seen the rise of a new generation of interdisciplinary scientists with a strong background in the biological and computational sciences. In this context, the interaction of researchers from different scientific fields is, more than ever, of foremost importance in boosting the research efforts in the field and contributing to the education of a new generation of Bioinformatics scientists. The PACBB'17 conference was intended to contribute to this effort and promote this fruitful interaction, with a technical program that included 39 papers spanning many different sub-fields in Bioinformatics and Computational Biology. Further, the conference promoted the interaction of scientists from diverse research groups and with a distinct background (computer scientists, mathematicians, biologists).
(source: Nielsen Book Data)9783319608150 20170814
EBSCOhost Access limited to 1 user
Book
1 online resource (70 p.) : digital, PDF file.
This report is an update to the 2013 report and provides a status of the markets and technology development involved in growing a domestic bioenergy economy as it existed at the end of 2015. It compiles and integrates information to provide a snapshot of the current state and historical trends influencing the development of bioenergy markets. This version features details on the two major bioenergy markets: biofuels and biopower and an overview of bioproducts that enable bioenergy production. The information is intended for policy-makers as well as technology developers and investors tracking bioenergy developments. It also highlights some of the key energy and regulatory drivers of bioenergy markets.
Los Alamos National Security, LLC (LANS) biologists in the Environmental Compliance and Protection Division at Los Alamos National Laboratory (LANL) initiated a multi-year program in 2013 to monitor avifauna at two open detonation sites and one open burn site on LANL property. Monitoring results from these efforts are compared among years and with avifauna monitoring conducted at other areas across LANL. The objectives of this study are to determine whether LANL firing site operations impact bird abundance or diversity. LANS biologists completed the fourth year of this effort in 2016. The overall results from 2016 continue to indicate that operations are not negatively affecting bird populations. Data suggest that community structure may be changing at some sites and this trend will continue to be monitored.
Book
online resource (xii, 367 pages, 12 unnumbered pages of plates) : illustrations
  • Durban and Johannesburg
  • Cape Town
  • Cambridge
  • The first visit to Israel
  • Back to Cambridge
  • Birkbeck-1
  • Birkbeck-2
  • The Laboratory of Molecular Biology
  • Image analysis in electron microscopy
  • Spherical virus structure
  • Tobacco mosaic virus
  • From thon rings to modern dance
  • Tomography
  • Transfer RNA
  • Chromatin and nucleosomes
  • Zinc fingers
  • Peterhouse
  • Director of the Laboratory of Molecular Biology
  • Presidency of the Royal Society
  • Ben Gurion University
  • Prizes
  • Envoi.
The atomic structures of macromolecules provide the key to understanding how life works. Aaron Klug led the way in the development of methods for solving such structures and is one of the pioneers of structural molecular biology. He was awarded a Nobel Prize in 1982 for his work. Illuminating both his personal life and scientific achievements, this unique biography begins with Klug's youth in Durban and his studies at Johannesburg, Cape Town and then Trinity College, Cambridge. Holmes proceeds to explore Klug's career from his work on the structure of viruses with Rosalind Franklin at Birkbeck College, London to his time as Director of the MRC Laboratory of Molecular Biology (LMB) in Cambridge and as President of the Royal Society. Drawing on their long-term collaboration, interviews and unique access to Klug's archives, Holmes provides a fascinating account of an innovative man and his place in the history of structural molecular biology.
Medical Library (Lane)
Book
1 online resource (12 p.) : digital, PDF file.
Fungi interact closely with bacteria, both on the surfaces of the hyphae and within their living tissues (i.e. endohyphal bacteria, EHB). These EHB can be obligate or facultative symbionts and can mediate diverse phenotypic traits in their hosts. Although EHB have been observed in many lineages of fungi, it remains unclear how widespread and general these associations are, and whether there are unifying ecological and genomic features can be found across EHB strains as a whole. We cultured 11 bacterial strains after they emerged from the hyphae of diverse Ascomycota that were isolated as foliar endophytes of cupressaceous trees, and generated nearly complete genome sequences for all. Unlike the genomes of largely obligate EHB, the genomes of these facultative EHB resembled those of closely related strains isolated from environmental sources. Although all analysed genomes encoded structures that could be used to interact with eukaryotic hosts, pathways previously implicated in maintenance and establishment of EHB symbiosis were not universally present across all strains. Independent isolation of two nearly identical pairs of strains from different classes of fungi, coupled with recent experimental evidence, suggests horizontal transfer of EHB across endophytic hosts. Given the potential for EHB to influence fungal phenotypes, these genomes could shed light on the mechanisms of plant growth promotion or stress mitigation by fungal endophytes during the symbiotic phase, as well as degradation of plant material during the saprotrophic phase. As such, these findings contribute to the illumination of a new dimension of functional biodiversity in fungi.
Book
1 online resource (p. 3103-3108) : digital, PDF file.
Electron cryomicroscopy (cryo-EM) has been used to determine the atomic coordinates (models) from density maps of biological assemblies. These models can be assessed by their overall fit to the experimental data and stereochemical information. However, these models do not annotate the actual density values of the atoms nor their positional uncertainty. Here, we introduce a computational procedure to derive an atomic model from a cryo- EM map with annotated metadata. The accuracy of such a model is validated by a faithful replication of the experimental cryo-EM map computed using the coordinates and associated metadata. The functional interpretation of any structural features in the model and its utilization for future studies can be made in the context of its measure of uncertainty. We applied this protocol to the 3.3-Å map of the mature P22 bacteriophage capsid, a large and complex macromolecular assembly. With this protocol, we identify and annotate previously undescribed molecular interactions between capsid subunits that are crucial to maintain stability in the absence of cementing proteins or cross-linking, as occur in other bacteriophages.