1 online resource (V, 239 p. 96 ill., 79 illus. in color.) : online resource. Digital: text file; PDF.
  • Spinal dural arteriovenous fistula - A review.- Intracranial Meningiomas-a 30 year experience and literature review.- Arteries and veins of the Sylvian fissure and Insula.- Hearing outcomes after stereotactic radiosurgery for vestibular schwannomas: Mechanism of hearing loss and how to preserve hearing.- Merits and Limits of various Tractography Techniques for the Un-initiated.- ALA guided surgery of high grade gliomas.- Clinical relevance of prognostic and predictive molecular markers in gliomas.
  • (source: Nielsen Book Data)9783319213583 20160619
This volume reviews standard treatments for spinal dural arteriovenous fistulas, examining the anatomy of arteries and veins of the sylvian fissure, as well as microsurgical advances and the development of modern therapeutic strategies in intracranial meningiomas. The advances section presents a strategy for minimizing hearing loss after stereotactic radiosurgery for vestibular schwannomas, as well as a description of the mode of action and biology of ALA, including its interaction with tumor cells and the limits of this method. A dedicated chapter addresses the essential question of the limits (and merits) of various tractography techniques and of their importance for non-specialists, who may be tempted to use them uncritically. A further chapter examines molecular markers, which have become standard in neuropathological reports on intracranial tumors, reviewing the prognostic and predictive value of these modern molecular markers in gliomas. Additional chapters round out the coverage, offering a comprehensive overview of standard and advanced techniques.
(source: Nielsen Book Data)9783319213583 20160619
1 online resource (Article No. 11313 ) : digital, PDF file.
Persistent neurogenesis in the dentate gyrus produces immature neurons with high intrinsic excitability and low levels of inhibition that are predicted to be more broadly responsive to afferent activity than mature neurons. Mounting evidence suggests that these immature neurons are necessary for generating distinct neural representations of similar contexts, but it is unclear how broadly responsive neurons help distinguish between similar patterns of afferent activity. Here we show that stimulation of the entorhinal cortex in mouse brain slices paradoxically generates spiking of mature neurons in the absence of immature neuron spiking. Immature neurons with high intrinsic excitability fail to spike due to insufficient excitatory drive that results from low innervation rather than silent synapses or low release probability. Here, our results suggest that low synaptic connectivity prevents immature neurons from responding broadly to cortical activity, potentially enabling excitable immature neurons to contribute to sparse and orthogonal dentate representations.
1 online resource.
  • Introduction
  • Bio-electronics Interfaces
  • Organic Devices for Electrophysiological Applications
  • The Micro Organic Charge Modulated FET Array
  • Experimental Results.-Conclusions.
This thesis reports on the Micro OCMFET Array, a novel, reference-less system for extracellular recordings of action potentials. The book provides readers with a full description of the system, together with an extensive report of the successful experimental trials carried out on both cardiac and nerve cells. Moreover, it offers a concise yet comprehensive overview of both bioelectronic interfaces, such as Micro Electrode Arrays (MEAs) and Field Effect Devices (FEDs), and organic sensors for electro- physiological applications, including Organic Charge-Modulated FETs (OCMFET), Electrolyte-Gated Organic FETs (EGOFETs), and Organic Electrochemical Transistors (OECTs).
1 online resource (444 p.)
  • Preface Acknowledgement Introduction Rapid Unsupervised Effective Causal Learning A General Noological Framework Conceptual Grounding and Operational Representation Causal Rules, Problem Solving, and Operational Representation The Causal Role of Sensory Information. Application to the StarCraft Game Environment A Grand Challenge for Noology and Computational Intelligence Affect Driven Noological Processes Summary and Beyond Appendix A: Causal vs Reinforcement Learning Appendix B: Rapid Effective Causal Learning Algorithm Index.
  • (source: Nielsen Book Data)9783319321110 20160815
The idea of this book is to establish a new scientific discipline, "noology, " under which a set of fundamental principles are proposed for the characterization of both naturally occurring and artificial intelligent systems. The methodology adopted in Principles of Noology for the characterization of intelligent systems, or "noological systems, " is a computational one, much like that of AI. Many AI devices such as predicate logic representations, search mechanisms, heuristics, and computational learning mechanisms are employed but they are recast in a totally new framework for the characterization of noological systems. The computational approach in this book provides a quantitative and high resolution understanding of noological processes, and at the same time the principles and methodologies formulated are directly implementable in AI systems. In contrast to traditional AI that ignores motivational and affective processes, under the paradigm of noology, motivational and affective processes are central to the functioning of noological systems and their roles in noological processes are elucidated in detailed computational terms. In addition, a number of novel representational and learning mechanisms are proposed, and ample examples and computer simulations are provided to show their applications. These include rapid effective causal learning (a novel learning mechanism that allows an AI/noological system to learn causality with a small number of training instances), learning of scripts that enables knowledge chunking and rapid problem solving, and learning of heuristics that further accelerates problem solving. Semantic grounding allows an AI/noological system to "truly understand" the meaning of the knowledge it encodes. This issue is extensively explored. This is a highly informative book providing novel and deep insights into intelligent systems which is particularly relevant to both researchers and students of AI and the cognitive sciences.
(source: Nielsen Book Data)9783319321110 20160815
1 online resource (VII, 59 p. 17 ill., 1 illus. in color.) : online resource. Digital: text file; PDF.
  • Preface.- Chapter 1 Introduction.-Chapter 2 Formation of phantom limbs following ischemic nerve block.- Chapter 3 A new type of hand-object illusion.- Chapter 4 Visual and proprioceptive adaptation of arm position in a virtual environment.- Chapter 5 Conclusion.- Acknowledgement.
  • (source: Nielsen Book Data)9789811014598 20160815
This book presents new findings on body image and also introduces new neuroscience-based methods for the fields of neurology and neurorehabilitation. Even when the hand is stationary we know its position - information that is needed by the brain to plan movements. If the sensory input from a limb is removed as the result of an accident, or as part of an experiment with local anesthesia, then a 'phantom' limb commonly develops. We used ischemic anesthesia of one limb to study the mechanisms that define this phenomenon. Surprisingly, if the fingers, wrist, elbow, ankle, and knee are extended before and during an ischemic block, then the perceived limb is flexed at the joint and vice versa. Furthermore, the limb is perceived to move continuously with no default position. The key parameter for these illusory changes in limb position is the difference in discharge rates between afferents in the flexor and extensor muscles at a joint. The final position of the phantom limb depends on its initial position, suggesting that a body image uses incoming proprioceptive information for determination of starting points and endpoints when generating movements. In addition, the change in position does not involve limb postures that are anatomically impossible, suggesting that illusory posture is constrained by body maps. These results provide new information about how the brain generates phantom limbs.
(source: Nielsen Book Data)9789811014598 20160815
1 online resource.
  • The Analyses of Global Gene Expression and Transcription Factor Regulation.- Global Approaches to Alternative Splicing and its Regulation - Recent Advances and Open Questions.- Long Non-coding RNAs: Critical Regulators for Cell Lineage Commitment in the Central Nervous System.- Gene expression models of signaling pathways.- From Gene Expression to Disease Phenotypes: Network-Based Approaches to Study Complex Human Diseases.- Introduction to Isoform Sequencing using Pacific Biosciences Technology (Iso-Seq).- Systematic and Integrative Analysis of Gene Expression to Identify Feature Genes Underlying Human Diseases.
  • (source: Nielsen Book Data)9789401774482 20160619
This volume focuses on modern computational and statistical tools for translational gene expression and regulation research to improve prognosis, diagnostics, prediction of severity, and therapies for human diseases. It introduces some of state of the art technologies as well as computational and statistical tools for translational bioinformatics in the areas of gene transcription and regulation, including the tools for next generation sequencing analyses, alternative spicing, the modeling of signaling pathways, network analyses in predicting disease genes, as well as protein and gene expression data integration in complex human diseases etc. The book is particularly useful for researchers and students in the field of molecular biology, clinical biology and bioinformatics, as well as physicians etc. Dr. Jiaqian Wu is assistant professor in the Vivian L. Smith Department of Neurosurgery and Center for Stem Cell and Regenerative Medicine, University of Texas Health Science Centre, Houston, TX, USA.
(source: Nielsen Book Data)9789401774482 20160619
1 online resource. Digital: text file; PDF.
  • Biomedical Signal Processing.- Biomedical Imaging and Image Processing.- Biosensors and Bioinstrumentation.- Bio-micro/nano Technologies.- Biomaterials.- Biomechanics, Robotics and Minimally Invasive Surgery.- Cardiovascular, Respiratory and Endocrine Systems Engineering.- Neural and Rehabilitation Engineering.- Molecular, Cellular and Tissue Engineering.- Bioinformatics and Computational Biology.- Clinical Engineering and Health Technology Assessment.- Health Informatics, E-health and Telemedicine.- Biomedical Engineering Education.- Biomimetic Organ-on-Chip Systems.- Nanotechnology and Pulsed Electric Fields.- Advanced techniques for treating deep seated tumor using Electrochemotherapy (ECT) and Irreversible Electroporation (IRE). Bioimpedance.- Workshop: Radiological Equipment Maintenance Issues.- Real-time neuroimaging of the human brain: Methods and applications.- Certification of clinical biomedical engineers: national and international perspectives.- AHP in healthcare decision making and user need elicitation.- Education BME-ENA.- Disaster Preparedness Program for Health Facility's Technology Managers.
  • (source: Nielsen Book Data)9783319111278 20160618
This volume presents the Proceedings of the 6th European Conference of the International Federation for Medical and Biological Engineering (MBEC2014), held in Dubrovnik September 7 - 11, 2014. The general theme of MBEC 2014 is "Towards new horizons in biomedical engineering" The scientific discussions in these conference proceedings include the following themes: - Biomedical Signal Processing - Biomedical Imaging and Image Processing - Biosensors and Bioinstrumentation - Bio-Micro/Nano Technologies - Biomaterials - Biomechanics, Robotics and Minimally Invasive Surgery - Cardiovascular, Respiratory and Endocrine Systems Engineering - Neural and Rehabilitation Engineering - Molecular, Cellular and Tissue Engineering - Bioinformatics and Computational Biology - Clinical Engineering and Health Technology Assessment - Health Informatics, E-Health and Telemedicine - Biomedical Engineering Education.
(source: Nielsen Book Data)9783319111278 20160618
p. 409-415 : digital, PDF file.
Visual function in vertebrates is dependent on the membrane-bound retinoid isomerase RPE65, an essential component of the retinoid cycle pathway that regenerates 11-cis-retinal for rod and cone opsins. The mechanism by which RPE65 catalyzes stereoselective retinoid isomerization has remained elusive because of uncertainty about how retinoids bind to its active site. Here we present crystal structures of RPE65 in complex with retinoid-mimetic compounds, one of which is in clinical trials for the treatment of age-related macular degeneration. The structures reveal the active site retinoid-binding cavity located near the membrane-interacting surface of the enzyme as well as an Fe-bound palmitate ligand positioned in an adjacent pocket. With the geometry of the RPE65–substrate complex clarified, we delineate a mechanism of catalysis that reconciles the extensive biochemical and structural research on this enzyme. Finally, these data provide molecular foundations for understanding a key process in vision and pharmacological inhibition of RPE65 with small molecules.
1 online resource. Digital: text file; PDF.
  • Peroxynitrite induces degradation of myosin heavy chain via p38 MAPK and muscle-specific E3 ubiquitin ligases in C2 skeletal myotubes. O. Rom, S. Kaisari, A.Z. Reznick, and D. Aizenbud Alterations in the coagulation system of active smokers from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. G. Delgado, R. Siekmeier, T.B. Grammer, B.O. Boehm, W. Marz, and M.E. Kleber. C-reactive protein and lipoprotein-associated phospholipase A2 in smokers and nonsmokers of the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study. M.E. Kleber, R. Siekmeier, G. Delgado, T.B. Grammer, B.R. Winkelmann, H. Scharnagl, B.O. Boehm, and W. Marz Green tea drinking improves erythrocytes and saliva oxidative status in the elderly. B. Narotzki, A.Z. Reznick, T. Mitki, D. Aizenbud, and Y. Levy Cardiovascular effects of N-acetylcysteine in meconium-induced acute lung injury. D. Mokra, I. Tonhajzerova, H. Pistekova, Z. Visnovcova, A. Drgova, J. Mokry, and A. Calkovska Alterations in vagal-immune pathway in long-lasting mental stress. Z. Visnovcova, D. Mokra, P. Mikolka, M. Mestanik, A. Jurko, M. Javorka, A. Calkovska, and I. Tonhajzerova Nocturnal parasympathetic modulation of heart rate in obesity-hypoventilation patients. A. Brzecka, M. Pawelec-Winiarz, A. Teplicki, P. Piesiak, and R. Jankowska N-acetylcysteine Alleviates the Meconium-Induced Acute Lung Injury. D. Mokra, A. Drgova, M. Petras, J. Mokry, M. Antosova, and A. Calkovska.
  • (source: Nielsen Book Data)9783319097213 20160618
Cardiorespiratory function is prominently affected by oxidative stress. Cigarette smoking is the archetype of oxidative and nitrative stress and free radical formation. New adverse effects of smoking keep on propping up in research. The chapters provide the comprehensive view of new developments in this area regarding cardiovascular and lung function and muscle catabolism. Alterations in inflammatory cytokines and proteins as well as degradation of muscle proteins due to smoking, by far unrecognized, caused by oxidative stress also are presented. Much less is known about the effect of cognitive stress on vagally-mediated cardiorespiratory function and surprisingly, on vagal immune pathway. The experimental studies also show that clinically important meconium aspiration syndrome contains an oxidative trait which is amenable to antioxidative treatment. This volume creates a source of information on the damaging role of oxidative stress in cardiorespiratory function that has by far not been available.
(source: Nielsen Book Data)9783319097213 20160618
1 online resource : ill.
  • Part I. Childhood. Cognitive Abilities in Childhood and Adolescence / Sally J. Wadsworth, Robin P. Corley and John C. DeFries
  • Interactions Between Socioeconomic Status and Components of Variation in Cognitive Ability / Eric Turkheimer and Erin E. Horn
  • Genetic and Environmental Influences on Intellectual Disability in Childhood / Michèle Carlier and Pierre L. Roubertoux
  • Part II. Adulthood. Cognition in Middle Adulthood / William S. Kremen and Caitlin S. Moore, Carol E. Franz, Matthew S. Panizzon and Michael J. Lyons
  • Normative Cognitive Aging / Wendy Johnson, Matt McGue and Ian J. Deary
  • Gene by Environment Interplay in Cognitive Aging / Chandra A. Reynolds, Deborah Finkel and Catalina Zavala
  • Dementia: Genes, Environments, Interactions / Margaret Gatz, Jung Yun Jang, Ida K. Karlsson and Nancy L. Pedersen
  • Part III. Biology and Neurobiology. Brain Imaging and Cognition / Iván Chavarría-Siles, Guillén Fernández and Danielle Posthuma
  • Animal Models of General Cognitive Ability for Genetic Research into Cognitive Functioning / Michael J. Galsworthy, Rosalind Arden and Christopher F. Chabris
  • Part IV. Conclusion. Future Directions / Deborah Finkel and Chandra A. Reynolds.
Behavior Genetics of Cognition across the Lifespan Deborah Finkel and Chandra A. Reynolds, editors Series: Advances in Behavioral Genetics Series Editor: Yong-Kyu Kim One of the primary advances for the 21st century is progress beyond the need to defend the findings of behavioral genetic investigations of intelligence. With the advent of developmental behavioral genetics-and molecular genetics-researchers have taken their discoveries far beyond simple nature/nurture constructs to a finer understanding of how genes and environment intersect to affect cognitive function. Behavior Genetics of Cognition across the Lifespan presents the state of the field in well-documented detail as noted experts examine gene-environment interactions in cognitive function from childhood into old age. Fluidity is at the heart of this coverage: normative and non-normative brain development get equal attention, and statistical, molecular, biological, brain imaging, and neurobiological approaches contribute separately and in combination to the findings. All major life stages are examined as periods of gene-based cognitive change, including midlife, which until recently has been considered a period for marking time until "real" age-related change occurs. And the book is written so that individual chapters can be as useful on their own as the volume is as a whole. Among the topics covered in depth: Cognitive abilities in childhood and adolescence Genetic and environmental influences on intellectual disabilities in childhood Cognition in middle adulthood Gene by environment interplay in cognitive aging Dementia: genes, environments, interactions Brain imaging and cognition By synthesizing where the field is today--and identifying issues that need further attention--Behavior Genetics of Cognition across the Lifespan is a bedrock text for behavioral geneticists, cognitive psychologists and neuroscientists.
1 online resource (295 pages)
Calculus of Thought: Neuromorphic Logistic Regression in Cognitive Machines is a must-read for all scientists about a very simple computation method designed to simulate big-data neural processing. This book is inspired by the Calculus Ratiocinator idea of Gottfried Leibniz, which is that machine computation should be developed to simulate human cognitive processes, thus avoiding problematic subjective bias in analytic solutions to practical and scientific problems. The reduced error logistic regression (RELR) method is proposed as such a "Calculus of Thought." This book reviews how RELR's completely automated processing may parallel important aspects of explicit and implicit learning in neural processes. It emphasizes the fact that RELR is really just a simple adjustment to already widely used logistic regression, along with RELR's new applications that go well beyond standard logistic regression in prediction and explanation. Readers will learn how RELR solves some of the most basic problems in today's big and small data related to high dimensionality, multi-colinearity, and cognitive bias in capricious outcomes commonly involving human behavior. Features include: provides a high-level introduction and detailed reviews of the neural, statistical and machine learning knowledge base as a foundation for a new era of smarter machines; argues that smarter machine learning to handle both explanation and prediction without cognitive bias must have a foundation in cognitive neuroscience and must embody similar explicit and implicit learning principles that occur in the brain; and offers a new neuromorphic foundation for machine learning based upon the reduced error logistic regression (RELR) method and provides simple examples of RELR computations in toy problems that can be accessed in spreadsheet workbooks through a companion website.
(source: Nielsen Book Data)9780124104075 20160612
online resource (xiii, 585 pages) : illustrations (some color) ; 26 cm
  • Part I. Neurohistological Techniques
  • Brain Tissue Preparation, Sectioning, and Staining / Jingdong Zhang and Huangui Xiong
  • Brain Stereotaxic Injection / Jingdong Zhang and Huangui Xiong
  • Neuronal Tract Tracing with Light and Electron Microscopy / Jingdong Zhang and Huangui Xiong
  • Stereological Analysis / Kristi M. Anderson, Adam M. Szlachetka and R. Lee Mosley
  • Part II. In Vitro Preparations
  • Preparation and Use of Rodent Hippocampal Slices / Huangui Xiong and Jianxun Xia
  • Single-Cell Neuronal Dissociation for Electrophysiological Studies / Yu-Long Li
  • Isolation and Culture of Human Neurons, Microglia, and Astrocytes / Li Wu and Santhi Gorantla
  • Isolation and Culture of Neural Stem/Progenitor Cells / Hui Peng, Qiang Chen and Jialin Zheng
  • Isolation of Mitochondria from Brain Tissue and Cells / Changhai Tian and Jialin Zheng
  • Isolation of Synaptosomes from Archived Brain Tissues / Gurudutt Pendyala, James L. Buescher and Howard S. Fox
  • Xenopus Oocytes Isolation and Microinjection / Huangui Xiong
  • Part III. Leukocyte Isolation and Application in Neuroscience
  • Centrifugal Elutriation for Studies of Neuroimmunity / Santhi Gorantla, Myhanh Che and Howard E. Gendelman
  • Flow Cytometry in Neuroscience Research / Charles Kuszynski
  • Part IV. Standard Laboratory Nucleic Acid and Protein Detections
  • Western Blotting Technique in Biomedical Research / Jianuo Liu, James Haorah and Huangui Xiong
  • Polymerase Chain Reaction (PCR) and Real-Time PCR / Georgette D. Kanmogne
  • Part V. Nanomedicine
  • Nanoformulations / Xin-Ming Liu and Tatiana K. Bronich
  • Neuronanomedicine / JoEllyn M. McMillan, Xin-Ming Liu and Howard E. Gendelman
  • Part VI. Bioimaging
  • Confocal Imaging of Nerve Cells / You Zhou
  • Magnetic Resonance Imaging / Yutong Liu
  • X-Ray, Positron Emission, and Single Photon Emission Tomographic Bioimaging / Katherine A. Estes, Jacob C. Peterson, Adam M. Szlachetka and R. Lee Mosley
  • Noninvasive Neurophysiological Imaging with Magnetoencephalography / Tony W. Wilson
  • Multiphoton Brain Imaging / Anna Dunaevsky
  • Part VII. Neuroelectrophysiology
  • Techniques for Extracellular Recordings / Jingdong Zhang, Jianxun Xia and Huangui Xiong
  • Blind Patch-Clamp Recordings from Rodent Hippocampal Slices / Jianxun Xia and Huangui Xiong
  • Whole-Cell Patch-Clamp Recording / Matthew J. Van Hook and Wallace B. Thoreson
  • Part VIII. Immunohistochemistry and Autoradiography
  • Analysis of Receptor Binding and Quantitative Autoradiography / L. Charles Murrin
  • Techniques in Immunohistochemistry and Immunocytochemistry / Yang Yuan and Jyothi Arikkath
  • Part IX. Analysis of Gene Expression
  • Protein Identification by Mass Spectrometry: Proteomics / Melinda Wojtkiewicz, Kelley Barnett and Pawel Ciborowski
  • DNA Microarrays as a Tool for Neurosciences Research / James D. Eudy, Lynette Smith
  • Metabolomics / Yazen Alnouti
  • Bioinformatic Methods and Resources for Neuroscience Research / Chittibabu Guda
  • Part X. Animal Models: Behavior and Pathology
  • Motor Function in Rodent Models of Neurodegenerative Disorders / Jessica A. Hutter Saunders, Max V. Kuenstling, Robert A. Weir, R. Lee Mosley and Howard E. Gendelman
  • Humanized Mice / Larisa Y. Poluektova and Edward Makarov
  • Animal Models for PD and ALS / Max V. Kuenstling, Adam M. Szlachetka and R. Lee Mosley
  • Animal Models of Alzheimer's Disease / Tomomi Kiyota
  • Animal Models: Behavior and Pathology: Preclinical Assessment of the Putative Cognitive Deficits in HAND / Landhing M. Moran, Rosemarie M. Booze and Charles F. Mactutus.
Current Laboratory Methods in Neuroscience Research is a research manual for both students and seasoned researchers. It focuses on commonly-used techniques employed in neuroscience research, presented in a simple, step-by-step manner for laboratory use. The manual also offers a blueprint for bench-to-bedside research designed to facilitate multidisciplinary neuroscience pursuits. Sections include coverage of neurohistological techniques, in vitro preparations, leukocyte isolation and application in neuroscience, standard laboratory nucleic acid and protein detections, nanomedicine, bioimaging, neuroelectrophysiology, immunohistochemistry and autoradiography, analysis of gene expression, and animal models.
Medical Library (Lane)
1 online resource (2 ) : digital, PDF file.
DOE Solid-State Lighting program technology fact sheet that provides background on current science and considerations related to LED light and health.
1 online resource.
Mathematical Neuroscience is a book for mathematical biologists seeking to discover the complexities of brain dynamics in an integrative way. It is the first research monograph devoted exclusively to the theory and methods of nonlinear analysis of infinite systems based on functional analysis techniques arising in modern mathematics. Neural models that describe the spatio-temporal evolution of coarse-grained variables - such as synaptic or firing rate activity in populations of neurons - and often take the form of integro-differential equations would not normally reflect an integrative approach. This book examines the solvability of infinite systems of reaction diffusion type equations in partially ordered abstract spaces. It considers various methods and techniques of nonlinear analysis, including comparison theorems, monotone iterative techniques, a truncation method, and topological fixed point methods. Infinite systems of such equations play a crucial role in the integrative aspects of neuroscience modeling. The first focused introduction to the use of nonlinear analysis with an infinite dimensional approach to theoretical neuroscience. It combines functional analysis techniques with nonlinear dynamical systems applied to the study of the brain. It introduces powerful mathematical techniques to manage the dynamics and challenges of infinite systems of equations applied to neuroscience modeling.
(source: Nielsen Book Data)9780124114685 20160612
1 online resource (ix, 220 pages) : illustrations (some color)
  • Biological roots of aggression Animal aggression
  • Heritability and genetic bases
  • The aggressive brain
  • The hormonal milieu
  • Aggression across the lifespan
  • development and functions
  • Aggression as a factor of temperament
  • Human aggression Biological background and social functions
  • Deviations from the norm
  • Criminal aggression
  • Aggression-related psychiatric disorders
  • Treatments
  • from psychosurgery to medications.-Neural mechanisms of abnormal aggression Psychiatric disorders and laboratory models
  • theoretical considerations
  • Neural background of abnormal aggression in laboratory models
  • Genetic models
  • Neurodevelopmental models
  • Hormonal models
  • Neural backgrounds
  • common and distinctive features
  • Abnormal aggression in people
  • Gene polymorphisms
  • Brain imaging
  • Hormones
  • Biology and psychopathology
  • an integrative view on aggression.
Mechanisms controlling aggressive behavior started to be identified from late 20's of the 20th century, and subsequent research described such mechanisms in great detail. While the findings are of great relevance for the understanding of aggression per se, they provide limited insights into the mechanisms of abnormal aggression i.e. those mechanisms that underlie aggression-related psychopathologies. While basic phenomena and mechanism of aggression are presented in this book, it is the first that comprehensively describes ultimate and proximate mechanisms that transform normal (laboratory animals) or tolerable (humans) manifestations of aggressiveness into abnormal patterns in laboratory animals and aggression-related psychopathologies in humans. This book is written for behavioral neurobiologists and neuroscientists, interested in social behavior in general and aggressive behavior in particular. The book will also offer important information to neurologists and psychiatrists dealing with aggressive behavior in the clinic and ultimately, may provide means to understand, and on the long run, to discover novel approaches to the treatment of abnormal human aggression.
1 online resource (xii, 132 pages) : illustrations (some color) Digital: text file; PDF.
  • Opioid and Non-Opioid Drug Responding Under States of Chronic Pain: A Timeline Spanning 1980 to Present Day
  • Opioid Self-Administration in the Presence of Chronic Pain: Analgesia or Addiction
  • The Influence of Pain on Reward Processing: Current Literature and Prospects
  • Chronic Pain Stimuli Downregulate Mesolimbic Dopaminergic Transmission: Possible Mechanism of the Suppression of Opioid Reward
  • Drug Addiction and Chronic Pain: A Review of Animal Models
  • Biopharmaceutical Considerations of Opioid Analgesics in Models of Self-Administration: Review and Summary
  • Prenatal Exposure to Opioids
  • Opioids in an Evidence-Based World.
Using rodent models, this volume explores the basic neurobiology of the relationship among chronic pain, opioid pharmacology, and addiction.
(source: Nielsen Book Data)9781493918553 20160618
1 online resource (1 v.) : ill.
The world of coaching is competitive. Organisations want coaches who deliver results, and can prove it. Many coaching tools and techniques are now fairly well established - but how do they actually work? The coach who can answer this question credibly and convincingly is sought after. This ground-breaking book equips coaches with cutting edge neuroscience information that will help them deliver greater value to their clients. It covers the foundations that coaches need to be aware of and crucially, the ways they can use this new information effectively and practically in their everyday work. Readers will strengthen their kitbag of coaching tools and will be able to explain to their clients the neurological underpinning of the techniques they are using. No forward-thinking coach can afford to be ignorant of recent scientific developments: Neuroscience for Coaches will give them the practical knowledge they need.
(source: Nielsen Book Data)9780749472368 20160617
1 online resource (x, 174 pages) : illustrations (some color)
  • 1 Introduction (Kazunori Sango and Junji Yamauchi)
  • 2 Recent insights into molecular mechanisms that control growth factor receptor-mediated Schwann cell morphological changes during development (Yuki Miyamoto and Junji Yamauchi)
  • 3 Membrane Skeleton in Schmidt-Lanterman Incisure in Schwann cells of Peripheral Nervous System (Nobuo Terada, Yurika Saitoh, Nobuhiko Ohno, and Shinichi Ohno)
  • 4 Schwann cell-axon interactions: the molecular and metabolic link between Schwann cells and axons (Nobuhiko Ohno, Takashi Sakoh, Yurika Saitoh, Nobuo Terada, and Shinichi Ohno)
  • 5 Schwann cell-dependent regulation of peripheral nerve injury and repair (Keiichiro Susuki)
  • 6 Charcot-Marie-Tooth disease (Toru Ogata)
  • 7 Expression of the transthyretin gene in Schwann cells, and familial amyloidotic polyneuropathy-mediated neurodegeneration (Tatsufumi Murakami and Yoshihide Sunada)
  • 8 Node of Ranvier disruption: a key pathophysiology in immune-mediated neuropathies (Keiichiro Susuki)
  • 9 Pathogenesis of diabetic neuropathy from the viewpoint of Schwann cell abnormalities (Koichi Kato, Eva L. Feldman, and Jiro Nakamura)
  • 10 Spontaneously immortalized adult rodent Schwann cells as valuable tools for the study of peripheral nerve degeneration and regeneration (Kazunori Sango, Masami Tsukamoto, Kazunori Utsunomiya, and Kazuhiko Watabe)
  • BM Index.
This book presents recent topics on the development, differentiation, and myelination of Schwann cells, as well as pathological mechanisms and therapeutic approaches for peripheral neuropathies, such as Charcot?Marie?Tooth diseases, amyloid polyneuropathy, immune-mediated neuropathy, and diabetic neuropathy. The rapid progress of molecular biological techniques in the last decades, especially for RNA techniques and gene modification technologies, have allowed us to investigate the pathobiology of Schwann cells in vivo and in vitro. Studies combining recent stem cell biology with recent biotechnology, which is now closely linked to physicochemical fields, further explain how Schwann cell lineages develop, a process that has long been thought to be very complicated in vivo. The findings contribute to the elucidation of fundamental mechanisms during development and under pathological conditions. We now know that these are closely tied to each other. This book also introduces unique coculture systems to reproduce the neuron Schwann cell interplay during development, degeneration, and regeneration. Up-to-date research topics with high-quality immunofluorescence and electron micrographs introduced by young and energetic contributors are sure to arouse the readers' interest in Schwann cell biology. Discussion from the viewpoint of basic and clinical neuroscience makes the book educational for researchers, medical students, and young clinicians.