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1 online resource (xvii, 978 pages) : illustrations (chiefly color)
  • Part 1. Endocrinology of Reproduction Chapter 1. Neuroendocrinology of Reproduction Chapter 2. Gonadotropin Hormones and Their Receptors Chapter 3. Prolactin in Human Reproduction Chapter 4. Steroid Hormones and Other Lipid Molecules Involved in Human Reproduction Chapter 5. Steroid Hormone Action Chapter 6. Growth Factors and Reproduction Chapter 7. Neuroendocrine Control of the Menstrual Cycle Chapter 8. The Ovarian Life Cycle Chapter 9. Structure, Function, and Evaluation of the Female Reproductive Tract Chapter 10. The Breast Chapter 11. Endocrinology of Human Pregnancy and Fetal-Placental Neuorendocrine Development Chapter 12. Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs Chapter 13. Immunology and Reproduction Chapter 14. Menopause and Aging Chapter 15. Male Reproductive Aging Part 2. Pathophysiology and Therapy: Pediatric, Adolescent, and Adult Chapter 16. Disorders of Sex Development Chapter 17. Puberty: Gonadarche and Adrenarche Chapter 18. Nutrition and Reproduction Chapter 19. Environmental Factors and Reproduction Chapter 20. Physiological and Pathophysiological Alterations of the Neuroendocrine Components of the Reproductive Axis Chapter 21. Polycystic Ovary Syndrome and Hyperandrogenic States Chapter 22. Female Infertility Chapter 23. Male Infertility Chapter 24. Endocrine Disturbances Affecting Reproduction Chapter 25. Endometriosis Chapter 26. Benign Uterine Diseases Chapter 27. Endocrine Diseases in Pregnancy Chapter 28. Transgender Hormonal Treatment Chapter 29. Hormone-Responsive Cancers Part 3. Reproductive Technologies Chapter 30. Medical Approaches to Ovarian Stimulation for Infertility Chapter 31. Assisted Reproduction Chapter 32. Gamete and Embryo Manipulation Chapter 33. Fertility Preservation Chapter 34. Laboratory Asessment Chapter 35. Pelvic Imaging in Reproductive Endocrinology Chapter 36. Contraception.
  • (source: Nielsen Book Data)9780323479127 20180416
Now celebrating its 40th anniversary, Yen & Jaffe's Reproductive Endocrinology, 8th Edition, by Drs. Jerome F. Strauss III, Robert L. Barbieri, and Antonio R. Gargiulo, keeps you up to date with the latest information on the diagnosis and management of the full range of female and male reproductive disorders. This cornerstone text thoroughly covers both basic science and clinical practice, making it a one-stop reference for all reproductive issues, including impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, and contraception. Every chapter has been completely revised and updated to reflect important changes in this fast-moving field. Covers key topics such as the role of genetics in reproductive endocrinology, environmental factors in reproductive endocrinology, and recent advances in surgical procedures. Features full-color, high-quality illustrations that clearly depict basic anatomic structures, endocrine processes, and cell function and dysfunction. Provides the knowledge and expertise of global experts who draw on the latest developments in the field to keep you abreast of current science and practice in endocrinology. Coverage includes molecular, cellular, and genetic concepts and their relevance to pathophysiology, diagnosis, and therapy. Features new bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section. Includes a new online video library that highlights surgical procedures, diagnostic imaging, and functional ultrasound imaging. Videos cover Disorders of Sex Development, Endometriosis, Benign Uterine Disorders, Gamete and Embryo Manipulation, and Fertility Preservation. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
(source: Nielsen Book Data)9780323479127 20180416
1 online resource (x, 495 pages) : illustrations (some color)
  • Section I Essential Concepts 1 Orientation to the Structure and Imaging of the Central Nervous System 2 The Cell Biology of Neurons and Glia 3 The Electrochemical Basis of Nerve Function 4 Chemical Signaling in the Nervous System 5 Development of the Nervous System Section II Regional Neurobiology 6 The Ventricles, Choroid Plexus, and Cerebrospinal Fluid 7 The Meninges 8 A Survey of the Cerebrovascular System 9 The Spinal Cord 10 An Overview of the Brainstem 11 The Medulla Oblongata 12 The Pons and Cerebellum 13 The Midbrain 14 A Synopsis of Cranial Nerves of the Brainstem 15 The Diencephalon 16 The Telencephalon Section III Systems Neurobiology 17 The Somatosensory System I: Tactile Discrimination and Position Sense 18 The Somatosensory System II: Nociception, Thermal Sense, and Touch 19 Viscerosensory Pathways 20 The Visual System 21 The Auditory System 22 The Vestibular System 23 Olfaction and Taste 24 Motor System I: Peripheral Sensory, Brainstem, and Spinal Influence on Anterior Horn Neurons 25 Motor System II: Corticofugal Systems and the Control of Movement 26 The Basal Nuclei 27 The Cerebellum 28 Visual Motor Systems 29 Visceral Motor Pathways 30 The Hypothalamus 31 The Limbic System 32 The Cerebral Cortex 33 The Neurologic Examination.
  • (source: Nielsen Book Data)9780323396325 20171211
Using a rigorous yet clinically-focused approach, Fundamental Neuroscience for Basic and Clinical Applications, 5th Edition, covers the fundamental neuroscience information needed for coursework, exams, and beyond. It integrates neuroanatomy, pharmacology, and physiology, and offers a full section devoted to systems neurobiology, helping you comprehend and retain the complex material you need to know. Highlights clinical content in blue throughout the text, helping you focus on what you need to know in the clinical environment.Presents thoroughly updated information in every chapter, with an emphasis on new clinical thinking as related to the brain and systems neurobiology. Features hundreds of correlated state-of-the-art imaging examples, anatomical diagrams, and histology photos - nearly half are new or improved for this edition. Pays special attention to the correct use of clinical and anatomical terminology, and provides new clinical text and clinical-anatomical correlations.
(source: Nielsen Book Data)9780323396325 20171211
1 online resource : color illustrations.
  • 1. Bubbles in the body: The not so good, the bad and the ugly 2. Driving force for gas bubble growth and dissolution 3. Rates of gas bubble growth and dissolution in simple liquids 4. Estimating the radii and lifetimes of small gas bubbles suspended in simple liquids 5. AGEs in scuba diving and in DCS-like problems in breath-hold diving 6. Gas bubbles in soft tissue-like solids 7. The evils that bubbles do 8. Compartmental decompression models and DCS risk estimation 9. Treating teh evils that bubbles do 10. Merging medicine and Mmath: Gas bubble dynamics in the treatment of gas-bubble disease.
  • (source: Nielsen Book Data)9780128105191 20171204
Gas Bubble Dynamics in the Human Body provides a broad range of professionals, from physicians working in a clinic, hospital or hyperbaric facility, to physical scientists trying to understand and predict the dynamics of gas bubble behavior in the body, with an interdisciplinary perspective on gas-bubble disease. Both iatrogenic and decompression-induced gas bubbles are considered. The basic medical and physiological aspects are described first, in plain language, with numerous illustrations that facilitate an intuitive grasp of the basic underlying medicine and physiology. Current issues in the field, particularly microbubbles and microparticles, and their possible role in gas-bubble disease are included. The physical and mathematical material is given at several levels of sophistication, with the "hard-core" math separated out in sections labelled "For the Math Mavens", so that the basic concepts can be grasped at a descriptive level. The field is large and multi-disciplinary, so that some of the discussion that is at a greater depth is given separately in sections labelled "In Greater Detail". Skipping these sections for whatever reason, shouldn't materially hamper acquiring an overall appreciation of the field.
(source: Nielsen Book Data)9780128105191 20171204
1 online resource (2 volumes : xxxvii, 1687, I24 pages) : illustrations (some color)
  • Volume 1 Section I: Basic Cell Physiology, Genetics, and Growth of the GI Tract Section II: Nerogastroenterology Section III: Host Defense Mechanisms Volume 2 Section IV: Physiology of Secretion Section V: Digestion and Absorption Section VI: Consequences of Disregulated Physiology.
  • (source: Nielsen Book Data)9780128099544 20180514
Physiology of the Gastrointestinal Tract, Sixth Edition, a Two-Volume set, covers the study of the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease and disorder, thus bridging the gap between clinical and laboratory medicine while also covering breakthroughs in gastroenterology, such as the brain-gut axis and microbiome. Additionally, information is provided at the organism level, including animal models of gastrointestinal disorders and therapeutic possibilities. The book covers a wide range of conditions, from food allergies, constipation, chronic liver disease and IBS, also exploring emerging techniques to diagnose and normalize functions of the GI tract. As a highly referenced book, this is a useful resource for gastroenterologists, physiologists, internists, professional researchers and instructors teaching courses for clinical and research students.
(source: Nielsen Book Data)9780128099544 20180514
1 online resource (xxxvii, pages) : illustrations (chiefly color), color portraits
  • Section I: History, chemistry metabolism, circulation & regulation. Historical overview of vitamin d
  • Evolutionary biology: mysteries of vitamin D in fish
  • Evolution of human skin color and vitamin D
  • Photobiology of vitamin D
  • The activating enzymes of vitamin D metabolism (25- and 1[alpha]-hydroxylases)
  • CYP24A1: structure, function, and physiological role
  • The vitamin D binding protein DBP
  • Regulation of renal and extra-renal 1[alpha]-hydroxylase
  • Section II. Mechanism of action. Genome-wide perspectives on vitamin D receptor-meditated control of gene expression in target cells
  • Diverse mechanisms of transcriptional regulation by the vitamin D receptor
  • Structural basis for ligand activity in VDR
  • Ligand independent actions of vitamin D receptor
  • Vitamin D and chromatin
  • Mesenchymal differentiation, epigenetic dynamics, and interactions with VDR
  • Vitamin D and microRNAs
  • Vitamin D sterol/VDR conformational dynamics and nongenomic actions
  • Section III. Mineral and bone homeostasis. Vitamin D regulation of osteoblast function
  • Osteoclastogenesis and vitamin D
  • Vitamin D activities in osteocytes
  • Regulation of intestinal calcium and phosphate absorption
  • Calbindin-D28K and calbindin-D9K and the epithelial calcium channels TRPV5 and TRPV6
  • Calcium homeostasis and eggshell biomineralization in female chicken
  • Mineralization in mammals
  • Cartilage
  • Vitamin D and bone: an integrated approach
  • Section IV. Extra-skeletal targets. Vitamin D and the kidney
  • Vitamin D and the parathyroids
  • The calcium-sensing receptor and vitamin d
  • Vitamin D in dentoalveolar and oral health
  • The role of vitamin D and its receptor in hair follicle biology
  • Vitamin D, calcium and the epidermis
  • Vitamin D and the cardiovascular system
  • Vitamin D brain development and function
  • Vitamin D, VDR and adipose tissue: focus on cellular mechanisms
  • Vitamin D and skeletal muscle
  • Understanding vitamin D from mouse knockout models
  • Section V. Human physiology. Pharmacology and pharmacokinetics
  • Vitamin D role in the calcium and phosphorus economies
  • Fetus, neonate and infant
  • Consequences of perinatal vitamin D deficiency on later bone health
  • Adolescence and acquisition of peak bone mass
  • Pregnancy, lactation, and post-weaning recovery
  • Role in reproductive biology and reproductive dysfunction in women
  • Vitamin d, reproductive biology, and dysfunction in men
  • Vitamin D and the renin-angiotensin system
  • Parathyroid hormone, parathyroid hormone-related protein, and calcitonin
  • FGF23 counter regulatory hormone for vitamin D actions on mineral metabolism, hemodynamics, and innate immunity
  • Section VI. Diagnosis and management. Approach to the patient with metabolic bone disease
  • Detection of 1,25-dihydroxyvitamin D in human serum using receptor assisted chemiluminescent hormone assay (REACH) technology
  • Mass spectrometry assays of vitamin D metabolites
  • Free vitamin d: concepts, assays, outcomes and prospects
  • 25-hydroxyvitamin D assays: standardization guidelines, problems and interpretation
  • Bone histomorphometry
  • Radiology of rickets and osteomalcia
  • High-resolution imaging techniques for bone quality assessment
  • The role of vitamin D in orthopedic surgery
  • The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the IOM Position
  • The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the endocrine society position
"Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin DSaves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articlesTargets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency. Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications"--Publisher's description.
1 online resource.
  • 1. Biometals and Alzheimer's Disease 2. Copper in Alzheimer's Disease 3. The Role of Selenium in Neurodegenerative Diseases 4. Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response? 5. Chemical Elements and Oxidative Status in Neuroinflammation 6. Metals and Neuroinflammation 7. Metals and Prions: Twenty Years of Mining the Awe 8. Manganese and Neurodegeneration 9. Zinc in Autism 10. Metals and Motor Neuron Disease 11. Metals and Lysosomal Storage Disorders 12. Developmental Exposure to Metals and its Contribution to Age-Related Neurodegeneration 13. Metal Biology Associated with Huntington's Disease 14. Metal-Binding to Amyloid-ss Peptide: Coordination, Aggregation, and Reactive Oxygen Species Production 15. Metals and Mitochondria in Neurodegeneration 16. Metal Transporters in Neurodegeneration 17. Metal Imaging in the Brain 18. Metalloregulation of Protein Clearance: New Therapeutic Avenues for Neurodegenerative Diseases 19. Metals and Autophagy in Neurotoxicity 20. An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases 21. Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases.
  • (source: Nielsen Book Data)9780128045626 20170612
Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer's Disease, Parkinson's Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.
(source: Nielsen Book Data)9780128045626 20170612
1 online resource (xvi, 641 pages)
  • Introduction xv PART I BIOPHYSICS OF COMPLEX SYSTEMS I. Kinetics of Biological Processes 3 1 Qualitative Methods for Studying Dynamic Models of Biological Processes 5 2 Types of Dynamic Behavior of Biological Systems 17 3 Kinetics of Enzyme Processes 29 4 Self-Organization Processes in Distributed Biological Systems 45 II. Thermodynamics of Biological Processes 77 5 Thermodynamics of Irreversible Processes in Biological Systems Near Equilibrium (Linear Thermodynamics) 79 6 Thermodynamics of Systems Far From Equilibrium (Nonlinear Thermodynamics) 91 PART II MOLECULAR BIOPHYSICS III. Three-dimensional Organization of Biopolymers 99 7 Three-dimensional Confi gurations of Polymer Molecules 101 8 Different Types of Interactions inMacromolecules 109 9 Conformational Energy and Three-dimensional Structure of Biopolymers 117 IV. Dynamic Properties of Globular Proteins 153 10 Protein Dynamics 155 11 Physical Models of Dynamic Mobility of Proteins 187 PART III BIOPHYSICS OF MEMBRANE PROCESSES V. Structure-functional Organization of Biological Membranes 227 12 Molecular Organization of Biological Membranes 229 13 Conformational Properties of Membranes 247 VI. Transport of Substances and Bioelectrogenesis 261 14 Nonelectrolyte Transport 263 15 Ion Transport. Ionic Equilibria 269 16 Electrodiffusion Theory of Ion Transport Across Membranes 281 17 Induced Ion Transport 287 18 Ion Transport in Channels 295 19 Ion Transport in Excitable Membranes 319 20 Active Transport 339 VII. Energy Transformation in Biomembranes 349 21 Electron Transport and Energy Transformation in Biomembranes 351 22 Physics of Muscle Contraction, Actin-Myosin Molecular Motor 365 23 Biophysics of Processes of Intracellular Signaling 379 VIII. Electronic Properties of Biopolymers 403 24 Fundamentals of Quantum Description of Molecules 405 25 Mechanisms of Charge Transfer and Energy Migration in Biomolecular Structures 425 26 Mechanisms of Enzyme Catalysis 481 27 Energy Transformation in Primary Processes of Photosynthesis 505 28 Electron-Conformational Interactions in Primary Processes of Photosynthesis 547 X. Primary Processes in Biological Systems 579 29 Photo-conversions of Bacteriorhodopsin and Rhodopsin 581 30 Photoregulatory and Photodestructive Processes 607 Further Reading 633 Index 635.
  • (source: Nielsen Book Data)9781119160250 20170807
Following up on his first book, Fundementals of Biophysics, the author, a well-known scientist in this area, builds on that foundation by offering the biologist or scientist an advanced, comprehensive coverage of biophysics. Structuring the book into four major parts, he thoroughly covers the biophysics of complex systems, such as the kinetics and thermodynamic processes of biological systems, in the first part. The second part is dedicated to molecular biophysics, such as biopolymers and proteins, and the third part is on the biophysics of membrane processes. The final part is on photobiological processes. This ambitious work is a must-have for the veteran biologist, scientist, or chemist working in this field, and for the novice or student, who is interested in learning about biophysics. It is an emerging field, becoming increasingly more important, the more we learn about and develop the science. No library on biophysics is complete without this text and its precursor, both available from Wiley-Scrivener.
(source: Nielsen Book Data)9781119160250 20170807
1 online resource.
  • Part One: Introduction to Discrimination Testing 1. History of sensory discrimination testing 2. Statistics for use in discrimination testing 3. Deciding which test to use in discrimination testing 4. Applications and limitations of discrimination testing Part Two: Methods and Analysis in Discrimination Testing: Practical Guidance 5. Paired comparison, directional difference test/2-alternative forced choice (2-AFC), Simple difference test/same different 6. A not A testing 7. Triangle testing 8. 2 out of 5 testing 9. Tetrad testing 10. Duo-trio: balanced and constant reference 11. Difference from Control 12. Ranking 13. ABX discrimination task 14. Dual standard testing 15. Analysis of the data Part Three: Future of Sensory Discrimination Testing 16. The future of sensory discrimination testing Appendices 17. A1: Where to find more information - ISO and ASTM standards 18. A2: Statistical tables.
  • (source: Nielsen Book Data)9780081010099 20170814
Discrimination Testing in Sensory Science: A Practical Handbook is a one-stop-shop for practical advice and guidance on the performance and analysis of discrimination testing in sensory science. The book covers all aspects of difference testing: the history and origin of different methods, the practicalities of setting up a difference test, replications, the statistics behind each test, dealing with the analysis, action standards, and the statistical analysis of results with R. The book is written by sensory science experts from both academia and industry, and edited by an independent sensory scientist with over twenty years of experience in planning, running and analyzing discrimination tests. This is an essential text for academics in sensory and consumer science and any sensory scientist working in research and development in food, home, and personal care products, new product development, or quality control.
(source: Nielsen Book Data)9780081010099 20170814
1 online resource.
  • 1. The need for engineering neural tissue using stem cells 2. Overview of the nervous system 3. Stem cells and their applications in repairing the damaged nervous system 4. Design considerations when engineering neural tissue from stem cells 5. Natural biomaterials for engineering neural tissue from stem cells 6. Synthetic biomaterials for engineering neural tissue from stem cells 7. Drug delivery systems for engineering neural tissue 8. New technologies for engineering neural tissue from stem cells.
  • (source: Nielsen Book Data)9780128113851 20171017
Engineering Neural Tissue from Stem Cells covers the basic knowledge needed to understand the nervous system and how existing cells can be used to create neural tissue. This book presents a broad range of topics related to the design requirements for engineering neural tissue from stem cells. It begins with the anatomy and function of the central and peripheral nervous system, also covering stem cells, their relation to the nervous system and their function in recovery after injury or disease. In addition, the book explores the role of the extracellular matrix and vasculature/immune system and biomaterials, including their suitability for neural tissue engineering applications.
(source: Nielsen Book Data)9780128113851 20171017
1 online resource
Experimental Methods in Orthopaedic Biomechanics is the first book in the field that focuses on the practicalities of performing a large variety of in-vitro laboratory experiments. Explanations are thorough, informative, and feature standard lab equipment to enable biomedical engineers to advance from a 'trial and error' approach to an efficient system recommended by experienced leaders. This is an ideal tool for biomedical engineers or biomechanics professors in their teaching, as well as for those studying and carrying out lab assignments and projects in the field. The experienced authors have established a standard that researchers can test against in order to explain the strengths and weaknesses of testing approaches.
1 online resource : illustrations (chiefly color)
  • Basic genetic principles
  • Prenatal diagnosis
  • Basic embryology
  • Regulation of embryogenesis
  • The extracellular matrix in development
  • Stem cell biology
  • Mechanisms of cell death in the developing brain
  • Angiogenesis
  • Epigenetics
  • Placental development
  • Regulation of the placental circulation
  • Mechanisms of transfer across the human placenta
  • Endocrine and paracrine function of the human placenta
  • Fetal and maternal responses to intraamniotic infection
  • Fetal origins of adult disease : a classic hypothesis with new relevance
  • Physiologic effects of multiple pregnancy on mother and fetus
  • Placental function in intrauterine growth restriction
  • Basic pharmacologic principles
  • Principles of pharmacokinetics
  • Physicochemical and structural properties regulating placental drug transfer
  • Pharmacogenetics
  • Drug distribution in fetal life
  • Drug transfer during breast-feeding
  • Circulatory and metabolic changes accompanying fetal growth restriction
  • Endocrine factors affecting neonatal growth
  • Human milk composition and function in the infant
  • Physiology of lactation
  • Fetal and neonatal iron metabolism
  • Neonatal calcium, phosphorus, and magnesium homeostasis
  • Zinc in the fetus and neonate
  • Vitamin a metabolism in the fetus and neonate
  • Vitamin e nutrition in the fetus and newborn
  • Vitamin k metabolism in the fetus and neonate
  • Maternal-fetal transfer of lipid metabolites
  • Brown adipose tissue : development and function
  • Lipids as an energy source for the premature and term neonate
  • Ketone body metabolism in the neonate
  • Long-chain polyunsaturated fatty acids in the developing central nervous system
  • Metabolism of glucose and methods of investigation in the fetus and newborn
  • Carbohydrate metabolism during pregnancy
  • Oxygen consumption and general carbohydrate metabolism of the fetus
  • Role of glucoregulatory hormones in hepatic glucose metabolism during the perinatal period
  • Cell glucose transport and glucose handling during fetal and neonatal development
  • General concepts of protein metabolism
  • Fetal requirements and placental transfer of nitrogenous compounds
  • Temperature control in newborn infants
  • Responses of the fetus and neonate to hypothermia
  • Structure and development of the skin and cutaneous appendages
  • Physiologic development of the skin
  • Cardiovascular development
  • Developmental electrophysiology in the fetus and neonate
  • Developmental biology of the pulmonary vasculature
  • Development of the gastrointestinal circulation in the fetus and newborn
  • Physiology of congenital heart disease in the neonate
  • Neural regulation of blood pressure during fetal and newborn life
  • Developmental effects on the fetal circulation
  • Mechanisms regulating closure of the ductus arteriosus
  • Umbilical circulation
  • Fetal and placental circulation during labor
  • Physiology of resuscitation
  • Normal and abnormal structural development of the lung
  • Regulation of alveolarization
  • Physiologic mechanisms of normal and altered lung growth before and after birth
  • Molecular mechanisms of lung development and lung branching morphogenesis
  • Regulation of liquid secretion and absorption by the fetal and neonatal lung
  • Upper airway structure : function, regulation, and development
  • Regulation of lower airway function
  • Functional development of respiratory muscles
  • Mechanics of breathing
  • Pulmonary gas exchange in the developing lung
  • Oxygen transport and delivery
  • Control of breathing in fetal life and onset and control of breathing in the neonate
  • Basic mechanisms of oxygen sensing and response to hypoxia
  • Evaluation of pulmonary function in the neonate
  • Mechanisms of neonatal lung injury
  • Impaired lung growth after injury in premature lung
  • Antenatal factors that influence postnatal lung development and injury
  • Regulation of pulmonary circulation
  • Historical perspective
  • Surfactant homeostasis : composition and function of pulmonary surfactant lipids and proteins
  • Structure and development of alveolar epithelial cells
  • Regulation of surfactant-associated phospholipid synthesis and secretion
  • Antenatal hormonal therapy for prevention of respiratory distress syndrome
  • Surfactant treatment
  • Genetics and physiology of surfactant protein deficiencies
  • Trophic factors and regulation of gastrointestinal tract and liver development
  • Organogenesis of the gastrointestinal tract
  • Development of the enteric nervous system
  • Development of gastric secretory function
  • Development of gastrointestinal motility
  • Development of the exocrine pancreas
  • Digestive-absorption functions in fetuses, infants, and children
  • The developing microbiome of the fetus and newborn
  • Organogenesis and histologic development of the liver
  • Bile acid metabolism during development
  • Neonatal bilirubin metabolism
  • Hereditary contribution to neonatal hyperbilirubinemia
  • Mechanistic aspects of phototherapy for neonatal hyperbilirubinemia
  • Development of the kidney : morphology and mechanisms
  • Functional development of the kidney in utero
  • Development and regulation of renal blood flow in the neonate
  • Development of the renin-angiotensin system
  • Postnatal development of glomerular filtration rate in neonates
  • Renal transport of sodium during development
  • Potassium homeostasis in the fetus and neonate
  • Role of the kidney in calcium and phosphorus homeostasis
  • Transport of amino acids in the fetus and neonate
  • Organic anion transport in the developing kidney
  • Concentration and dilution of urine
  • Urinary acidification
  • Response to nephron loss in early development
  • Fluid distribution in the fetus and neonate
  • Regulation of acid-base balance in the fetus and neonate
  • Developmental biology of stem cells : from the embryo to the adult
  • Developmental granulocytopoiesis
  • Developmental erythropoiesis
  • Developmental megakaryocytopoiesis
  • Developmental hemostasis
  • Platelet--vessel wall interactions
  • Host defense mechanisms against bacteria
  • Host defense mechanisms against fungi
  • Host defense mechanisms against viruses
  • T cell development
  • B cell development
  • Mononuclear phagocyte system
  • Normal and abnormal neutrophil physiology in the newborn
  • The complement system of the fetus and newborn
  • Cytokines and inflammatory response in the fetus and neonate
  • Immunology of human milk
  • Neonatal pulmonary host defense
  • Development of the nervous system
  • Development of the blood-brain barrier
  • Trophic factor, nutritional, and hormonal regulation of brain development
  • Intraventricular hemorrhage in the neonate
  • Cerebellar development—the impact of preterm birth and comorbidities
  • Electroencephalography in the preterm and term infant
  • Developmental aspects of pain
  • Early development of the human auditory system
  • Development of olfaction and taste in the human fetus and neonate
  • The growth plate : embryologic origin, structure, and function
  • Ontogenesis of striated muscle
  • Hypothalamus : neuroendometabolic center
  • Growth factor regulation of fetal growth
  • Growth hormone, prolactin, and placental lactogen in the fetus and newborn
  • Luteinizing hormone and follicle-stimulating hormone secretion in the fetus and newborn infant
  • Development of the corticotropin-releasing hormone--corticotropin system in the mammalian fetus
  • Fetal and neonatal adrenocortical physiology
  • Fetal and neonatal thyroid physiology
  • Genetics of sex determination and differentiation
  • Differentiation of the ovary
  • Testicular development and descent
  • Pathophysiology of neonatal sepsis
  • Pathophysiology of neonatal hypoglycemia
  • Pathophysiology of cardiomyopathies
  • Pathophysiology of persistent pulmonary hypertension of the newborn
  • Pathophysiology of shock in the fetus and neonate
  • Pathophysiology of apnea of prematurity
  • Pathophysiology of respiratory distress syndrome
  • Pathophysiology of meconium aspiration syndrome
  • Pathophysiology of bronchopulmonary dysplasia
  • Pathophysiology of ventilator-dependent infants
  • Pathophysiology of gastroesophageal reflux
  • Pathophysiology of neonatal necrotizing enterocolitis
  • Pathophysiology of kernicterus
  • Pathophysiology of neonatal acute kidney injury
  • Pathophysiology of edema
  • Pathophysiology of retinopathy of prematurity
  • Pathophysiology of hypoxic-ischemic brain injury
  • Pathophysiology of neonatal white matter injury
  • Pathophysiology of neonatal bacterial meningitis
  • Pathophysiology of neural tube defects
  • Pathophysiology of preeclampsia
  • Pathophysiology of preterm birth
  • Pathophysiology of chorioamnionitis : host immunity and microbial virulence.
Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this 2-volume resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner.
(source: Nielsen Book Data)9780323352147 20160912
1 online resource (973 pages) : illustrations (chiefly color)
  • Contributors xx Acknowledgements xxii Preface xxiii Prefixes, suffixes xxvii How to use your textbook xli About the companion website xlii Chapter 1 Basic scientific principles of physiology 1 Peter S Vickers Chapter 2 Cells, cellular compartments, transport systems, fluid movement between compartments 29 Muralitharan Nair Chapter 3 Genetics 61 Peter S Vickers Chapter 4 Tissue 95 Anthony Wheeldon Chapter 5 The skeletal system 121 Ian Peate Chapter 6 The muscular system 153 Janet G Migliozzi Chapter 7 Circulatory system 185 Muralitharan Nair Chapter 8 The cardiac system 223 Carl Clare Chapter 9 The digestive system 257 Louise McErlean Chapter 10 The renal system 299 Muralitharan Nair Chapter 11 The respiratory system 333 Anthony Wheeldon Chapter 12 The reproductive systems 371 Ian Peate Chapter 13 The nervous system 403 Louise McErlean and Janet G Migliozzi Chapter 14 The senses 439 Carl Clare Chapter 15 The endocrine system 479 Carl Clare Chapter 16 The immune system Peter S Vickers Chapter 17 The skin 551 Ian Peate Normal values 575 Answers 579 Index 603.
  • (source: Nielsen Book Data)9781119055525 20180611
Fundamentals of Anatomy and Physiology for Nursing and Healthcare Students is a succinct but complete overview of the structure and function of the human body, with clinical applications throughout. Designed specifically for nursing and healthcare students, the new edition of this best-selling textbook provides a user-friendly, straightforward, jargon-free introduction to the subject. Key features: Clinical considerations and scenarios throughout showing how the material can be applied to daily practice Featuring over 300 superb full colour illustrations Now includes a boxed feature throughout on medicines management; providing information concerning a variety of medicines used in the care and management of people that are related to the body system of the chapter The Conditions feature within each chapter provides you with a list of disorders that are associated with the topics discussed, helping relate theory to practice Each chapter includes learning outcomes, test your knowledge, scenarios, activities and summaries. Includes a list of prefixes and suffixes, as well as normal values, and a glossary of terms Supported by enhanced online resources with fantastic extras for both lecturers and students, including an image bank, online glossary, flashcards, interactive multiple choice questions, examples of patient notes, and more This edition is now supported by an accompanying study guide to facilitate the learning and revision of the content within this book: Fundamentals of Anatomy and Physiology Workbook: A Study Guide for Nurses and Healthcare Students.
(source: Nielsen Book Data)9781119055525 20180611
1 online resource (579 p.) : ill. (some col.)
"What is bioengineering all about? How will it impact the future? Can it find the cure for diabetes and other chronic diseases? A long-awaited continuation of the 2004 book, Understanding the Human Machine: A Primer for Bioengineering, this volume intends to address these questions and more. Written together with 18 scientists active in the field, Max E. Valentinuzzi brings his decades of teaching bioengineering and physiology at the undergraduate and graduate levels to readers, giving a profound, and sometimes philosophical, insight into the realm of bioengineering."--Publisher's website.
1 online resource (1 streaming video file (44 min.) : color, sound).
  • Contents: Enamel biology
  • Enamel structure & morphology
  • Enamel microanatomy
  • Enamel decussation & fractures
  • Enamel mechanical properties
  • Environmental background & human evolution
  • Tooth size, bite forces & enamel integrity.
1 online resource (1 streaming video file (19 min.) : color, sound).
  • Contents: Bone biology
  • Bone structure
  • Collagen fiber orientation
  • Aging & fractures
  • Osteocyte density.
1 online resource (1 streaming video file (45 min.) : color, sound).
  • Contents: Aging (senescence) our evolved life history
  • Global maximum life expectancy
  • Postmenopausal survival characterizes all human populations
  • Longevity affects age at maturity across our primate order
  • Comparing humans and chimpanzees
  • Grandmother effects and the evolution of human life history
  • What physiological mechanisms have slowed human aging?
  • Age-specific fertility rates in humans & chimpanzees
  • Overall mortality effects on age-specific variation.
1 online resource (238 p.)
  • Chapter 1: Personal monitoring and health data acquisition in smart homesChapter 2: Contactless monitoring of respiratory activity using electromagnetic waves for ambient assisted living framework: feasibility study and prototype realizationChapter 3: Technology-based assistance of people with dementia: state of the art, open challenges, and future developmentsChapter 4: Wearable sensors for gesture analysis in smart healthcare applicationsChapter 5: Design and prototyping of an innovative home automation system for the monitoring of elderly peopleChapter 6: Multi-sensor platform for circadian rhythm analysisChapter 7: Smart multi-sensor solutions for ADL detectionChapter 8: Comprehensive human monitoring based on heterogeneous sensor networkChapter 9: Ambient intelligence for health: advances in vital signs and gait monitoring systems within mHealth environmentsChapter 10: Smartphone-based blood pressure monitoring for falls risk assessment: techniques and technologies.
  • (source: Nielsen Book Data)9781785611513 20171017
Interest in Information and Communication Technologies for human monitoring, smart health and assisted living is growing due to the significant impact that these technologies are expected to have on improving the quality of life of ageing populations around the world. This book brings together chapters written by a range of researchers working in these topics, providing an overview of the areas and covering current research, developments and applications for a readership of researchers and research-led engineering practitioners. It discusses the promises and the possible advantages of these technologies, and also indicates the challenges for the future. Topics covered include: personal monitoring and health data acquisition in smart homes; contactless monitoring of respiratory activity; technology-based assistance of people with dementia; wearable sensors for gesture analysis; design and prototyping of home automation systems for the monitoring of elderly people; multi-sensor platform for circadian rhythm analysis; smart multi-sensor solutions for activity detection; human monitoring based on heterogeneous sensor networks; mobile health for vital signs and gait monitoring systems; and smartphone-based blood pressure monitoring for falls risk assessment.
(source: Nielsen Book Data)9781785611513 20171017
1 online resource : illustrations
  • Lists of Contributors xiii 1 Natural Products as Enzyme Inhibitors 1David M. Pereira, Catarina Andrade, Patricia Valentao, and Paula B. Andrade 1.1 Why Are Natural Products Good Enzyme Inhibitors? 1 1.2 Drawbacks of Natural Products 4 1.3 The Future of Natural Products Drug Discovery 5 1.3.1 New Sources and New Production Methods 5 1.3.2 New Strategies for Delivery 9 1.3.3 New Targets?/Drug Repurposing 12 1.4 Conclusion 13 References 13 2 Molecular Targets of Clinically Relevant Natural Products from Filamentous Marine Cyanobacteria 19Lik T. Tan 2.1 Introduction 19 2.2 Histone Deacetylase Inhibitors 20 2.2.1 Largazole 20 2.2.2 Santacruzamate A 22 2.3 Proteasome Inhibitors 23 2.3.1 Carmaphycins 23 2.4 Protease Enzymes 24 2.4.1 Serine Protease Inhibitors 24 2.4.2 Falcipain Inhibitors 27 Gallinamide A 27 2.4.3 Cathepsin Inhibitors 28 2.4.4 ss?-Secretase 1 (BACE1) Inhibitors 30 Tasiamide B 30 2.5 Protein Kinase C Modulators 30 2.5.1 Aplysiatoxins 30 2.6 Interference of the Actin and Microtubule Filaments 31 2.6.1 Dolastatins 10/15 31 2.6.2 Bisebromoamide 32 2.7 Sec61 Protein Translocation Channel Inhibitors 32 2.7.1 Apratoxin A 32 2.8 Prohibitin Inhibitors 34 2.8.1 Aurilide 34 2.9 Sodium Channels Modulators 35 2.10 Conclusions 35 References 36 3 Natural Angiotensin Converting Enzyme (ACE) Inhibitors with Antihypertensive Properties 45Maria Margalef, Francisca I. Bravo, Anna Arola-Arnal, and Begona Muguerza 3.1 Introduction 45 3.2 Mechanisms of Blood Pressure Regulation 46 3.2.1 Renin-Angiotensin-Aldosterone System 46 3.3 The Treatment of Hypertension 47 3.3.1 Angiotensin Converting Enzyme Inhibitors 47 3.4 Natural Products as Angiotensin Converting Enzyme Inhibitors 50 3.4.1 Polyphenols 50 3.4.2 Protein Derived Peptides 55 3.5 Conclusions 58 References 58 4 Phospholipase A2 Inhibitors of Marine Origin 69Tania Silva, David M. Pereira, Patricia Valentao, and Paula B. Andrade 4.1 Relevance of Marine Organisms 69 4.2 Inflammation 69 4.2.1 Phospholipase A2 70 4.3 Marine Molecules as PLA2 Inhibitors 72 4.3.1 Sponge?]Derived Metabolites 72 4.3.2 Metabolites from Other Organisms 83 4.4 Conclusion 86 References 86 5 ss-Secretase (BACE1) Inhibitors from Natural Products 93Wei?-Shuo Fang, Deyang Sun, Shuang Yang, and Na Guo 5.1Introduction 93 5.2 Flavonoids 94 5.2.1 Flavones, Flavonols and Flavone Glycosides 95 5.2.2 Dihydroflavonoids 96 5.2.3 Biflavonoids 98 5.2.4 Chalcones 100 5.2.5 Isoflavonoids 102 5.2.6 Catechins 102 5.2.7 Xanthones 104 5.3 Chromones 104 5.4 Phenolic Acids and Tannins 105 5.4.1 Phenol Acids 105 5.4.2 Tannins 106 5.4.3 Simple Phenol Derivatives and Polyphenols 107 5.5 Stilbenes and Derivatives 110 5.6 Coumarins 112 5.7 Benzoquinones and Anthraquinones 114 5.8 Alkaloids 116 5.9 Terpenes 118 5.10 Lignans 120 5.11 Fatty Acid 121 5.12 Saccharides, Peptides and Amino Acid Derivatives 121 5.13 BACE1 Inhibitory Active Extracts of Natural Products 122 5.14 Bioassays for the Discovery of BACE1 Inhibitors 124 5.15 Prospective 124 5.16 Acknowledgements 125 References 125 6 Hypoglycaemic Effects of Plants Food Constituents via Inhibition of Carbohydrate-Hydrolysing Enzymes: From Chemistry to Future Applications 135Monica R. Loizzo, Marco Bonesi, Seyed M. Nabavi, Eduardo Sobarzo?]Sanchez, Luca Rastrelli, and Rosa Tundis 6.1 Introduction 135 6.2 α-Amylase 136 6.3 α-Glucosidase 137 6.4 Hypoglycaemic Natural Compounds 137 6.4.1 Flavonoids 139 6.4.2 Phenolic Acids 141 6.4.3 Terpenoids 142 6.4.4 Alkaloids 147 6.4.5 Tannins 150 Ellagitannins 150 6.4.6 Miscellaneous 152 6.5 Conclusions and Future Perspective 152 Abbreviations 153 References 153 7 Natural Products Targeting Clinically Relevant Enzymes of Eicosanoid Biosynthesis Implicated in Inflammation and Cancer 163Gorla V. Reddy, Nagendra S. Yarla, Shobha Ediga, Dinesh K. Tiwari, Naresh Kumar, Sandhya Singh, Vasundhra Bhandari, Anupam Bishayee, Chintalapally V. Rao, and Pallu Reddanna 7.1 Introduction 163 7.2 Eicosanoid Biosynthetic Pathways 164 7.2.1 Phospholipases 165 7.2.2 Cyclooxygenases 166 7.2.3 Lipoxygenases 166 7.2.4 Cytochrome P450 (CYP)?]dependent Monooxygenases 166 7.3 Eicosanoid Biosynthetic Pathways in Inflammation and Cancer 167 7.3.1 Role of PLA2s in Inflammation and Cancer 167 7.3.2 Role of COXs in Inflammation and Cancer 168 7.3.3 Role of LOXs in Inflammation and Cancer 169 7.3.4 Role of CYP?]dependent Monooxygenases in Inflammation and Cancer 170 7.4 Natural Products as Anti-inflammatory Agents 170 7.4.1 Natural Products from Plant Origin 170 Baicalein 170 Berberine 171 Chebulagic Acid 172 Curcumin 172 Ellagic Acid 173 Epigallocatechin?]3?]Gallate 174 Eugenol 174 Fisetin 174 Gallic Acid 175 Genistein 175 Guggulsterone 176 Piperine 176 Quercetin 177 Resveratrol 178 Silibinin 178 Terpenoids 179 Triptolids 180 Ursolic Acid (UA) 181 7.4.2 Natural Products from Marine Origin 182 Axinelline A 182 Scalaradial 182 Tetrapetalone 183 7.4.3 Natural Products from Microorganisms 183 C?]Phycocyanin 183 Kojic Acid 184 Lobaric Acid 185 7.5 Conclusions and Future Directions 185 References 186 8 Anti-HIV Natural Products 209Tzi B. Ng, Jack H. Wong, Chi F. Cheung, Charlene C. W. Ng, Tak F. Tse, and Helen Chan 8.1 Introduction 209 8.2 Ribosome-Inactivating Proteins 209 8.3 Reverse Transcriptase Inhibitors 210 8.3.1 Antifungal Proteins 210 8.3.2 Defensins and Defensin?]Like Anti?]Fungal Peptides 210 8.3.3 Cathelicidins 210 8.3.4 Whey Proteins 211 8.3.5 Proteases and Protease Inhibitors 211 8.3.6 Lectins 211 8.3.7 Laccases and Ribonucleases 212 8.3.8 Polysaccharides and Polysaccharopeptides 212 8.3.9 Other HIV?]Reverse Transcriptase Inhibitors 212 8.4 Inhibitors of HIV Reverse Transcriptase Associated RNase H 213 8.5 HIV-1 Protease Inhibitors 213 8.6 HIV-1 Integrase Inhibitors 214 8.7 Discussion 214 Acknowledgements 216 References 216 9 Natural Inhibitors of Mitochondrial Respiratory Chain: Therapeutic and Toxicological Implications 225Fernando Pelaez, Nuria de Pedro, and Jose R. Tormo 9.1 Introduction: The Structure of the Electron Transport Chain 225 9.2 Natural Inhibitors of the Respiratory Chain 228 9.2.1 Complex I Inhibitors 228 Acetogenins from Annonaceae as Complex I Inhibitors 231 9.2.2 Complex II Inhibitors 233 9.2.3 Complex III Inhibitors 234 9.2.4 Complex IV Inhibitors 235 9.2.5 Complex V Inhibitors 237 9.3 Therapeutic, Agrochemical and Toxicological Implications 239 9.3.1 ETC Inhibitors as Fungicides 239 9.3.2 ETC Inhibitors as Insecticides, Acaricides, and Anthelmintic Agents 240 9.3.3 ETC Inhibitors with Activity Against Protozoan Parasites 241 9.3.4 Diabetes and ETC Inhibition 241 9.3.5 ETC Inhibition as a Therapeutic Strategy in Cancer 242 Mechanistic Insights on the Anti?]Tumour Properties of ETC Inhibitors 244 9.3.6 Toxicological Implications of ETC Inhibition 245 Neurotoxicity and ETC Inhibition 245 Other Toxicity Aspects of ETC Inhibition 246 9.4Conclusions 247 References 247 10 Targeting Enzymatic Pathways with Marine-Derived Clinical Agents 255Renato B. Pereira, Ramesh Dasari, Florence Lefranc, Alexander Kornienko, Robert Kiss, and Nelson G. M. Gomes 10.1 Marine Environment as an Established Source of Drug Candidates 255 10.2 Enzyme-Targeting Derived Effects of Marine-Derived Approved Drugs 256 10.3 Marine-Derived Agents in Clinical Development Targeting Relevant Enzymatic Pathways 261 10.4 Concluding Remarks 264 Acknowledgements 265 References 265 11 Anti-Malarial Drug Discovery: New Enzyme Inhibitors 277Raghu Raj and Vipan Kumar 11.1 Introduction 277 11.2 Falcipain (FP-2) Inhibitors 278 11.3 Purine Nucleoside Phosphorylase Inhibitors (PNP) 284 11.4 Dihydrofolate Reductase (DHFR) and Thymidylate Synthase (TS) Inhibitors 286 11.5 Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase Inhibitors 290 11.6 Conclusion 293 References 293 12 Natural Plant-Derived Acetylcholinesterase Inhibitors: Relevance for Alzheimer's Disease 297Nady Braidy, Anne Poljak, Tharusha Jayasena, and Perminder Sachdev 12.1 Introduction 297 12.2 Natural Acetylcholinesterase Inhibitors 299 12.2.1 Alkaloid Acetylcholinesterase Inhibitors 302 Rutaceae 302 Nelumbonaceae 303 Papaveraceae 303 Menispermaceae 303 Magnoliaceae 304 Apocynaceae 304 Amaryllidaceae 304 Lycopodiaceae 305 Buxaceae 305 Liliaceae 306 12.2.2 Non?]Alkaloid Acetylcholinesterase Inhibitors 306 Asparagaceae 306 Chenopodiaceae 306 Clusiaceae 307 Gentianaceae 307 Fabaceae 307 Lamiaceae 307 Moraceae 308 Iridaceae 308 Zygophyllaceae 308 Sterculiaceae 308 Combretaceae 309 Myristicaceae 309 Anacardiaceae 309 Nelumbonaceae 309 12.3 Conclusion 309 Acknowledgements 309 References 310 Index 319.
  • (source: Nielsen Book Data)9783527805938 20171009
The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
(source: Nielsen Book Data)9783527805938 20171009
1 online resource.
Neurobiological Background of Exploration Geosciences: New Methods for Data Analysis Based on Cognitive Criteria examines the neurobiological background of earth science disciplines. It presents the fundamental features of the human brain that form the cognitive basis of exploration geophysics and investigates how their analysis can drive the development of new brain-based technologies. Crucial aspects of human cognition include the impulse to explore the environment, the ability of our brain to create mental maps and virtual images of the world, and the human ability to recognize, integrate and save patterns of information in a shared memory. Geoscience technology can be made more effective by taking the working neurobiological principles of our brains into account. This book is appropriate for multiple audiences, including neuroscientists, cognitive scientists and geoscientists, presenting both theoretical and experimental results.
1 online resource (436 p.)
  • Section I. Chemical Biology 1. Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling Processes 2. Nitric oxide redox biochemistry in lipid environments 3. Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitration 4. Systems Approaches to Unraveling Nitric Oxide Response Networks in Prokaryotes Section II. Principles of Biology A. Nitric Oxide Synthases 5. Uncoupling of endothelial NO synthase (eNOS) in cardiovascular disease and its pharmacological reversal 6. Tetrahydrobiopterin: An essential cofactor for Nitric Oxide Synthases and Amino Acid Hydroxylases 7. Regulation of the expression of inducible nitric oxide synthase 8. Molecular Regulation of Inducible Nitric Oxide Synthase B. Guanylate Cyclase and Cyclic GMP 9. Soluble Guanylate Cyclase: Allosteric Activation and Redox Regulation C. Nitric Oxide Signaling 10. Untargeted Discovery of NO-modified Proteins 11. Fatty Acid Transduction of Nitric Oxide Signaling: Cyclooxygenases, Lipoxygenases and Nitro-Fatty Acids 12. Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1 13. The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide D. Regulation of Nitric Oxide Production 14. Nitric oxide-asymmetric dimethylarginine system in endothelial cell senescence E. Nitric Oxide and Remodeling 15. The Role of Nitric Oxide in Apoptosis and Autophagy: Biochemical and Computational Studies F. Nitrite and Nitrate 16. NO formation from inorganic nitrate and nitrite 17. Mechanisms of nitrite reduction in ischemia in the cardiovascular system: therapeutic potential 18. Nitrite Therapy for Ischemic Syndromes 19. Nitrite and heme globins: Reaction mechanisms and physiological targets Section III. Principles of Pathobiology A. Nitric Oxide and Cardiovascular Function 20. Nitric Oxide in Vascular Damage and Regeneration 21. Free radicals as atherosclerotic risk-The relation of NO- 22. The role of oxidative stress in endothelial dysfunction and vascular inflammation B. Pathophysiological Mechanisms of Nitric Oxide 23. Nitric oxide, oxidative stress, immune response and critical care 24. Reactive Metabolites of Oxygen and Nitrogen in Liver Ischemia and Reperfusion Injury 25. Nitric oxide in airway inflammation 26. Novel therapeutic applications of nitric oxide (NO) in the inhibition of tumor malignancy and reversal of resistance.
  • (source: Nielsen Book Data)9780128042731 20170911
Nitric Oxide: Biology and Pathobiology, Third Edition, provides information on nitric oxide, a signaling molecule of key importance for the cardiovascular system that regulates blood pressure and blood flow to different organs. With recent links to the role of nitric oxide in the expression of healthy benefits of controlled diet and aerobic exercise, and the reactions of nitric oxide that can impact cell signaling, this book provides a comprehensive resource during a time when increased research attention is being paid across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology.
(source: Nielsen Book Data)9780128042731 20170911