Book
1 online resource
Experimental Methods in Orthopaedic Biomechanics is the first book in the field that focuses on the practicalities of performing a large variety of in-vitro laboratory experiments. Explanations are thorough, informative, and feature standard lab equipment to enable biomedical engineers to advance from a 'trial and error' approach to an efficient system recommended by experienced leaders. This is an ideal tool for biomedical engineers or biomechanics professors in their teaching, as well as for those studying and carrying out lab assignments and projects in the field. The experienced authors have established a standard that researchers can test against in order to explain the strengths and weaknesses of testing approaches.
Book
1 online resource : illustrations (chiefly color)
  • Basic genetic principles
  • Prenatal diagnosis
  • Basic embryology
  • Regulation of embryogenesis
  • The extracellular matrix in development
  • Stem cell biology
  • Mechanisms of cell death in the developing brain
  • Angiogenesis
  • Epigenetics
  • Placental development
  • Regulation of the placental circulation
  • Mechanisms of transfer across the human placenta
  • Endocrine and paracrine function of the human placenta
  • Fetal and maternal responses to intraamniotic infection
  • Fetal origins of adult disease : a classic hypothesis with new relevance
  • Physiologic effects of multiple pregnancy on mother and fetus
  • Placental function in intrauterine growth restriction
  • Basic pharmacologic principles
  • Principles of pharmacokinetics
  • Physicochemical and structural properties regulating placental drug transfer
  • Pharmacogenetics
  • Drug distribution in fetal life
  • Drug transfer during breast-feeding
  • Circulatory and metabolic changes accompanying fetal growth restriction
  • Endocrine factors affecting neonatal growth
  • Human milk composition and function in the infant
  • Physiology of lactation
  • Fetal and neonatal iron metabolism
  • Neonatal calcium, phosphorus, and magnesium homeostasis
  • Zinc in the fetus and neonate
  • Vitamin a metabolism in the fetus and neonate
  • Vitamin e nutrition in the fetus and newborn
  • Vitamin k metabolism in the fetus and neonate
  • Maternal-fetal transfer of lipid metabolites
  • Brown adipose tissue : development and function
  • Lipids as an energy source for the premature and term neonate
  • Ketone body metabolism in the neonate
  • Long-chain polyunsaturated fatty acids in the developing central nervous system
  • Metabolism of glucose and methods of investigation in the fetus and newborn
  • Carbohydrate metabolism during pregnancy
  • Oxygen consumption and general carbohydrate metabolism of the fetus
  • Role of glucoregulatory hormones in hepatic glucose metabolism during the perinatal period
  • Cell glucose transport and glucose handling during fetal and neonatal development
  • General concepts of protein metabolism
  • Fetal requirements and placental transfer of nitrogenous compounds
  • Temperature control in newborn infants
  • Responses of the fetus and neonate to hypothermia
  • Structure and development of the skin and cutaneous appendages
  • Physiologic development of the skin
  • Cardiovascular development
  • Developmental electrophysiology in the fetus and neonate
  • Developmental biology of the pulmonary vasculature
  • Development of the gastrointestinal circulation in the fetus and newborn
  • Physiology of congenital heart disease in the neonate
  • Neural regulation of blood pressure during fetal and newborn life
  • Developmental effects on the fetal circulation
  • Mechanisms regulating closure of the ductus arteriosus
  • Umbilical circulation
  • Fetal and placental circulation during labor
  • Physiology of resuscitation
  • Normal and abnormal structural development of the lung
  • Regulation of alveolarization
  • Physiologic mechanisms of normal and altered lung growth before and after birth
  • Molecular mechanisms of lung development and lung branching morphogenesis
  • Regulation of liquid secretion and absorption by the fetal and neonatal lung
  • Upper airway structure : function, regulation, and development
  • Regulation of lower airway function
  • Functional development of respiratory muscles
  • Mechanics of breathing
  • Pulmonary gas exchange in the developing lung
  • Oxygen transport and delivery
  • Control of breathing in fetal life and onset and control of breathing in the neonate
  • Basic mechanisms of oxygen sensing and response to hypoxia
  • Evaluation of pulmonary function in the neonate
  • Mechanisms of neonatal lung injury
  • Impaired lung growth after injury in premature lung
  • Antenatal factors that influence postnatal lung development and injury
  • Regulation of pulmonary circulation
  • Historical perspective
  • Surfactant homeostasis : composition and function of pulmonary surfactant lipids and proteins
  • Structure and development of alveolar epithelial cells
  • Regulation of surfactant-associated phospholipid synthesis and secretion
  • Antenatal hormonal therapy for prevention of respiratory distress syndrome
  • Surfactant treatment
  • Genetics and physiology of surfactant protein deficiencies
  • Trophic factors and regulation of gastrointestinal tract and liver development
  • Organogenesis of the gastrointestinal tract
  • Development of the enteric nervous system
  • Development of gastric secretory function
  • Development of gastrointestinal motility
  • Development of the exocrine pancreas
  • Digestive-absorption functions in fetuses, infants, and children
  • The developing microbiome of the fetus and newborn
  • Organogenesis and histologic development of the liver
  • Bile acid metabolism during development
  • Neonatal bilirubin metabolism
  • Hereditary contribution to neonatal hyperbilirubinemia
  • Mechanistic aspects of phototherapy for neonatal hyperbilirubinemia
  • Development of the kidney : morphology and mechanisms
  • Functional development of the kidney in utero
  • Development and regulation of renal blood flow in the neonate
  • Development of the renin-angiotensin system
  • Postnatal development of glomerular filtration rate in neonates
  • Renal transport of sodium during development
  • Potassium homeostasis in the fetus and neonate
  • Role of the kidney in calcium and phosphorus homeostasis
  • Transport of amino acids in the fetus and neonate
  • Organic anion transport in the developing kidney
  • Concentration and dilution of urine
  • Urinary acidification
  • Response to nephron loss in early development
  • Fluid distribution in the fetus and neonate
  • Regulation of acid-base balance in the fetus and neonate
  • Developmental biology of stem cells : from the embryo to the adult
  • Developmental granulocytopoiesis
  • Developmental erythropoiesis
  • Developmental megakaryocytopoiesis
  • Developmental hemostasis
  • Platelet--vessel wall interactions
  • Host defense mechanisms against bacteria
  • Host defense mechanisms against fungi
  • Host defense mechanisms against viruses
  • T cell development
  • B cell development
  • Mononuclear phagocyte system
  • Normal and abnormal neutrophil physiology in the newborn
  • The complement system of the fetus and newborn
  • Cytokines and inflammatory response in the fetus and neonate
  • Immunology of human milk
  • Neonatal pulmonary host defense
  • Development of the nervous system
  • Development of the blood-brain barrier
  • Trophic factor, nutritional, and hormonal regulation of brain development
  • Intraventricular hemorrhage in the neonate
  • Cerebellar development—the impact of preterm birth and comorbidities
  • Electroencephalography in the preterm and term infant
  • Developmental aspects of pain
  • Early development of the human auditory system
  • Development of olfaction and taste in the human fetus and neonate
  • The growth plate : embryologic origin, structure, and function
  • Ontogenesis of striated muscle
  • Hypothalamus : neuroendometabolic center
  • Growth factor regulation of fetal growth
  • Growth hormone, prolactin, and placental lactogen in the fetus and newborn
  • Luteinizing hormone and follicle-stimulating hormone secretion in the fetus and newborn infant
  • Development of the corticotropin-releasing hormone--corticotropin system in the mammalian fetus
  • Fetal and neonatal adrenocortical physiology
  • Fetal and neonatal thyroid physiology
  • Genetics of sex determination and differentiation
  • Differentiation of the ovary
  • Testicular development and descent
  • Pathophysiology of neonatal sepsis
  • Pathophysiology of neonatal hypoglycemia
  • Pathophysiology of cardiomyopathies
  • Pathophysiology of persistent pulmonary hypertension of the newborn
  • Pathophysiology of shock in the fetus and neonate
  • Pathophysiology of apnea of prematurity
  • Pathophysiology of respiratory distress syndrome
  • Pathophysiology of meconium aspiration syndrome
  • Pathophysiology of bronchopulmonary dysplasia
  • Pathophysiology of ventilator-dependent infants
  • Pathophysiology of gastroesophageal reflux
  • Pathophysiology of neonatal necrotizing enterocolitis
  • Pathophysiology of kernicterus
  • Pathophysiology of neonatal acute kidney injury
  • Pathophysiology of edema
  • Pathophysiology of retinopathy of prematurity
  • Pathophysiology of hypoxic-ischemic brain injury
  • Pathophysiology of neonatal white matter injury
  • Pathophysiology of neonatal bacterial meningitis
  • Pathophysiology of neural tube defects
  • Pathophysiology of preeclampsia
  • Pathophysiology of preterm birth
  • Pathophysiology of chorioamnionitis : host immunity and microbial virulence.
Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this 2-volume resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner.
(source: Nielsen Book Data)9780323352147 20160912
Book
1 PDF (xv, 135 pages).
  • 1. Introduction
  • 1.1 Enabling technologies
  • 1.1.1 Camera-based systems
  • 1.1.2 Body worn sensors
  • 1.1.3 Force and pressure-based systems
  • 1.2 Body tracking in context
  • 1.3 Overview
  • 2. Clinical assessment of motor disability
  • 2.1 Introduction
  • 2.2 Tracking disease progression in multiple sclerosis assessment
  • 2.2.1 Contexts and practices in MS assessment with the EDSS
  • 2.2.2 Challenges and characteristics of assessment room
  • 2.2.3 Doctor-patient relationship in assessment
  • 2.2.4 Summary
  • 2.3 Understanding concerns in system design: assess MS system
  • 2.3.1 System overview
  • 2.3.2 Algorithms
  • 2.3.3 Movement exercise protocol
  • 2.3.4 Ensuring standardized movement performance
  • 2.3.5 Framing and standardization, seeing how the machine sees
  • 2.3.6 Representing the movement measure and classification
  • 2.4 Conclusions
  • 3. Self-directed rehabilitation and care
  • 3.1 Introduction
  • 3.2 Facilitating physical activity in chronic musculoskeletal pain
  • 3.3 Technology for chronic pain rehabilitation
  • 3.3.1 Go-with-the-flow: sonification in movement rehabilitation
  • 3.3.2 Transferring to everyday functioning: kinect vs. wearable smartphone as a body-tracking device
  • 3.3.3 Self-directed rehabilitation as process: from clinical facilitation to self-management
  • 3.3.4 Tracking affective states and pain levels
  • 3.4 Exergaming and balance rehabilitation in older adults
  • 3.4.1 Balance and fall risk in older adults
  • 3.4.2 Body-tracking technology for balance training
  • 3.4.3 Designing a balance training game
  • 3.4.4 Understanding rehabilitative game use
  • 3.5 Conclusion
  • 4. Interactions for clinicians
  • 4.1 Introduction
  • 4.2 Sterility and constraints on imaging practices
  • 4.3 Tracking the body of the clinician for enabling touchless interaction with images
  • 4.4 Clinical considerations in gesture design
  • 4.4.1 Clinical constraints on movement in gesture design
  • 4.4.2 Supporting collaboration and control
  • 4.4.3 What actions and body parts to track for the purposes of system control
  • 4.4.4 Engaging and disengaging the system
  • 4.4.5 Feedback and making oneself sensed
  • 4.4.6 Coarse vs. fine-grained control
  • 4.5 Body tracking, gesture, and robotics
  • 4.6 Increasing interaction bandwidth through input modality
  • 4.7 Conclusions
  • 5. Conclusions
  • 5.1 Introduction
  • 5.2 Contextual design
  • 5.2.1 Sensor technology
  • 5.2.2 Data and algorithms
  • 5.2.3 Designing movements
  • 5.2.4 Interface and interaction design
  • 5.2.5 Physical set-up and form factor
  • 5.2.6 Social set-up and practices
  • 5.3 The future
  • Bibliography
  • Author biographies.
Within the context of healthcare, there has been a long-standing interest in understanding the posture and movement of the human body. Gait analysis work over the years has looked to articulate the patterns and parameters of this movement both for a normal healthy body and in a range of movement-based disorders. In recent years, these efforts to understand the moving body have been transformed by significant advances in sensing technologies and computational analysis techniques all offering new ways for the moving body to be tracked, measured, and interpreted. While much of this work has been largely research focused, as the field matures, we are seeing more shifts into clinical practice. As a consequence, there is an increasing need to understand these sensing technologies over and above the specific capabilities to track, measure, and infer patterns of movement in themselves. Rather, there is an imperative to understand how the material form of these technologies enables them also to be situated in everyday healthcare contexts and practices. There are significant mutually interdependent ties between the fundamental characteristics and assumptions of these technologies and the configurations of everyday collaborative practices that are possible them. Our attention then must look to social, clinical, and technical relations pertaining to these various body technologies that may play out in particular ways across a range of different healthcare contexts and stakeholders. Our aim in this book is to explore these issues with key examples illustrating how social contexts of use relate to the properties and assumptions bound up in particular choices of body-tracking technology. We do this through a focus on three core application areas in healthcare-assessment, rehabilitation, and surgical interaction-and recent efforts to apply body-tracking technologies to them.
(source: Nielsen Book Data)9781627054560 20160619
Video
1 online resource (1 streaming video file (36 min.) : color, sound).
  • Contents: Cardiac aging in human and animal models
  • Molecular mechanisms for cardiac aging
  • Recent advances on potential interventions for cardiac aging
  • Future perspectives of cardiac aging interventions.
Book
1 online resource.
  • List of Contributors xi 1 Carotenoids: Overview of Nomenclature, Structures, Occurrence, and Functions 1 Agnieszka Kaczor, Malgorzata Baranska, and Krzysztof Czamara 1.1 Introduction 1 1.2 Nomenclature and structures 2 1.3 Occurrence and functions 7 1.3.1 Functions in plants 7 1.3.2 Antioxidants in humans 8 1.3.3 Role in visual and cognitive function 8 1.3.4 Carotenoids in human skin 8 1.3.5 Signaling function 9 1.3.6 Industrial applications 9 1.3.7 Carotenoids of specified properties 9 References 10 Part I Therapy 15 2 The Role of Antioxidants in Prevention of Premature Skin Aging 17 Jurgen Lademann, Maxim Evgen evich Darvin, Fanny Knorr, Sascha Jung, Leonhard Zastrow, and Martina Claudia Meinke 2.1 Introduction 17 2.2 State of the art 17 2.2.1 Solar radiation and skin aging 17 2.2.2 Carotenoids and the antioxidants of the human skin 18 2.2.3 Factors influencing the antioxidant status of the skin 20 2.2.4 Antioxidants and sun protection 21 2.2.5 Antioxidants and skin aging 22 2.2.6 Investigations into the antioxidant status of high school students 22 2.2.7 Accumulation of antioxidants in human skin by systemic and topical application 23 2.2.8 Ethnic influences on the antioxidant status 24 2.2.9 The antioxidant status in pregnant women and neonates 25 2.3 Summary 26 Conclusions 26 References 27 3 Antitumor Activity of Dietary Carotenoids, and Prospects for Applications in Therapy: Carotenoids and Cancer by Raman Imaging 31 Halina Abramczyk and Jakub Surmacki 3.1 Results 33 3.2 Conclusions 38 3.3 Perspectives 38 References 39 4 Photoprotection and Radiation Protection by Dietary Carotenoids 43 Fritz Boehm, Ruth Edge, Terence George Truscott, and Christian Witt 4.1 Introduction 43 4.2 Carotenoids and singlet oxygen 44 4.2.1 Organic solvents 44 4.2.2 Cell models 46 4.2.3 Cells 47 4.3 Radicals 48 4.3.1 Radical cations 48 4.3.2 Carotenoid radical adducts 49 4.3.3 Neutral radicals 50 4.3.4 Radical anions 51 4.3.5 The interaction of CARs with the superoxide radical and its protonated conjugated acid 51 4.4 Future prospects and challenges 53 4.5 Conclusion 53 Acknowledgments 54 References 54 5 Macular Carotenoids: Human Health Aspects 59 Aruna Gorusupudi and Paul S. Bernstein 5.1 Introduction 59 5.2 Macular pigment distribution 60 5.3 Human health aspects 61 5.4 Age?]related macular degeneration (AMD) 61 5.5 Macular carotenoid absorption 63 5.6 Stereochemistry and metabolism of macular carotenoids 65 5.7 Measurement of macular carotenoids 67 5.8 Conclusions and perspectives 68 References 68 Part II Spectroscopy 75 6 Vibrational Spectroscopy as a Tool to Investigate Carotenoids 77 Jan Cz. Dobrowolski 6.1 Introduction 77 6.2 Vibrations of carotenoids 77 6.2.1 Geometry 78 6.2.2 Geometrical cis?]trans isomerism 78 6.2.3 Syn?]periplanar (s?]cis) or anti?]periplanar (s?]trans) conformations 79 6.2.4 ?]electron delocalization 79 6.2.5 The nature, shape, and energy of the electronic ground and excited states 79 6.2.6 Electron affinity, ionization, reduction, and oxidation potentials 80 6.2.7 The nature and shape of molecular vibrations and vibrational coupling patterns 80 6.2.8 The role of methyl groups attached to the polyene chain and the end groups 81 6.3 Recent applications of vibrational spectroscopy to study natural carotenoids 81 6.3.1 Bacteria lichens and algae 83 6.3.2 Corals and pearls 87 6.3.3 Art and archeology 90 6.4 Perspectives 91 Acknowledgments 92 References 92 7 Structural Studies of Carotenoids in Plants, Animals, and Food Products 103 Takashi Maoka 7.1 Introduction 103 7.2 Extraction and pre?]preparation of carotenoids 103 7.3 Chromatography and separation of carotenoids 105 7.3.1 Column chromatography and thin?]layer chromatography 105 7.3.2 High?]performance liquid chromatography 105 7.4 Quantification of carotenoids 106 7.5 Identification and structural elucidation of carotenoids 106 7.5.1 Chemical dramatization 107 7.5.2 UV?]Vis, IR, and Raman spectrometry 107 7.5.3 Mass spectrometry 108 7.5.4 NMR spectrometry 111 7.6 Determination of absolute configuration of carotenoids 120 7.6.1 Circular dichroism (CD) spectroscopy 120 7.6.2 NMR spectrometry using the modified Mosher method 122 7.6.3 Synthetic approach 123 7.6.4 X?]ray crystallography 124 7.6.5 Examples of structural determination of natural carotenoids 124 7.7 Conclusion (future prospects and challenges) 126 Acknowledgments 126 References 127 8 In Situ Studies of Carotenoids in Plants and Animals 131 Malgorzata Baranska, Jan Cz. Dobrowolski, and Grzegorz Zajac 8.1 Introduction 131 8.2 Plants 131 8.3 Animals 134 8.4 Humans 137 8.4.1 Skin 137 8.4.2 Macular pigment 139 8.4.3 Carotenoids in single human cells 140 8.5 Perspectives 142 Acknowledgments 143 References 143 9 Carotenoids in Pigment Protein Complexes: Relation between Carotenoid Structure and Function 147 Wieslaw I. Gruszecki 9.1 Biological functions of carotenoids 147 9.2 Carotenoids in pigment protein complexes 149 9.3 Final remarks 154 9.4 Perspectives 155 Acknowledgments 155 References 155 Part III Technology 159 10 Carotenoid Biosynthesis and Regulation in Plants 161 Rafal Baranski and Christopher I. Cazzonelli 10.1 Biosynthetic pathways 161 10.1.1 Occurrence in nature 161 10.1.2 Cellular localization and compartmentalization 162 10.1.3 Pathways to generate isoprenoid precursors for carotenoid biosynthesis 163 10.1.4 The main pathway toward carotenoid biosynthesis 165 10.1.5 Specialty branches of the pathway 169 10.2 Regulation of carotenoid biosynthesis 170 10.2.1 Cross?]talk between and within the carotenoid and MEP pathways 171 10.2.2 Environmental and developmental control 171 10.2.3 Regulation by epigenetic and posttranscriptional mechanisms 172 10.2.4 Carotenoids in plastid biogenesis, differentiation, and control 173 10.2.5 Enzyme localization and metabolon compartmentalization 174 10.2.6 Carotenoid degradation and production of signaling metabolites 175 10.3 Biofortification and health perspectives 178 Acknowledgments 179 References 179 11 Carotenoid Bioavailability from the Food Matrix: Toward Efficient Extraction Procedures 191 Hartwig Schulz 11.1 Introduction 191 11.2 Occurrence of carotenoids in food materials 193 11.3 Bioavailability and bioefficiency of carotenoids 194 11.4 Extraction of carotenoids from various food matrices 197 11.5 Conclusions 210 11.6 Perspectives 211 References 211 12 Carotenoid Production by Bacteria, Microalgae, and Fungi 217 Ralf Martin Schweiggert and Reinhold Carle 12.1 Introduction 217 12.2 Microbial biosynthesis of carotenoids 218 12.3 Carotenoid?]rich microorganisms 223 12.3.1 Microalgae 223 12.3.2 Yeasts and filamentous fungi 225 12.3.3 Bacteria 226 12.4 Selected examples of biotechnological carotenoid production 228 12.4.1 Production of ?]carotene 228 12.4.2 Production of astaxanthin 230 12.4.3 Production of lycopene 232 12.4.4 Production of lutein and zeaxanthin 233 12.5 Perspectives and conclusions 234 References 235 13 Impact of Stress Factors on Carotenoid Composition, Structures, and Bioavailability in Microbial Sources 241 Agnieszka Kaczor and Marta Z. Pacia 13.1 Introduction 241 13.2 Light 242 13.3 Temperature 246 13.4 Carbon and nitrogen sources 249 13.5 Aerobic versus anaerobic conditions 250 13.6 Inorganic and organic salts 250 13.7 Other chemical agents 253 13.8 pH 253 13.9 Multiple stress factors 254 13.10 Perspectives and conclusions 254 Acknowledgments 255 References 255 14 Syntheses with Carotenoids 261 Hans?]Richard Sliwka and Vassilia Partali 14.1 Introduction 261 14.2 Reaction with double bonds 263 14.2.1 Hydrogenation 263 14.2.2 Halogenation 263 14.2.3 Oxidation 263 14.2.4 Electron transfer from and to carotenoids 264 14.2.5 Iron carbonyl 264 14.2.6 Nitration 265 14.2.7 In?]chain modification 265 14.3 Transformation of substituents 265 14.3.1 C=O C=C 265 14.3.2 CH=O CH=S 267 14.3.3 C=O C=S 268 14.3.4 C=O C OH 268 14.3.5 Inversion of OH 269 14.3.6 OH F, Cl, Br, and I 269 14.3.7 OH SR, SCN, SH, N2, NH2, and SeR 269 14.3.8 OH OR 270 14.3.9 OH glycosides 271 14.3.10 Reactions with carotenoid epoxides 271 14.3.11 Reactions with halogen carotenoids 271 14.3.12 Metal complexes with carotenols, carotenals, and carotenones 272 14.4 Preparative derivatization 272 14.5 Syntheses with carotenoid acids and carotenols 272 14.5.1 COOH COCl 273 14.5.2 COOH COO M+ 273 14.5.3 COOH COOR 273 14.5.4 COOR COOH 277 14.5.5 COOH CONH2 279 14.5.6 COOH CO O OC (carotenoid anhydrides) 279 14.6 Carotenoid reactions with Au 280 14.7 Valuation and conclusion 281 Acknowledgments 282 References 283 Index 291.
  • (source: Nielsen Book Data)9781118622223 20170313
Carotenoids are an essential component of the human diet. Bioactive by nature, they are rich in antioxidants, promote vitamin A activity and lower the development of chronic illnesses. As such they are an area of growing interest to researchers and scientists who are working to design, develop and launch new functional food products, dietary supplements and other nutritional solutions. Carotenoids: Nutrition, Analysis and Technology is an up-to-date overview of the key areas of carotenoids in nutrition, therapy and technology. In the first section, the authors present a functional food perspective, outlining the therapeutic applications of the bioactive pigments. The second part is dedicated to the spectroscopic analysis of carotenoids, providing in-depth scientific methods and real research findings. In the final section, various technological applications of carotenoids are considered, including biotechnology and future prospects. Written by international experts in the field, this comprehensive book will be of interest to food scientists and researchers, nutritionists and health food companies. It will be of particular use to anyone involved in the spectroscopic analysis of carotenoids and other related bioactives.
(source: Nielsen Book Data)9781118622261 20170313
Book
online resource (x, 438 pages) : color illustrations ; 19 cm
  • Fundamentals / S. Silbernagl and F. Lang
  • Temperature, energy / S. Silbernagl
  • Blood / S. Silbernagl
  • Kidney, salt and water balance / F. Lang
  • Stomach, intestines, liver / S. Silbernagl
  • Heart and circulation / S. Silbernagl
  • Metabolic disorders / S. Silbernagl
  • Hormones / F. Lang
  • Neuromuscular and sensory systems / F. Lang.
Medical Library (Lane)
Book
1 online resource (284 ill., 186 illus. in color. eReference.) : online resource. Digital: text file; PDF.
  • â General aspects, definitions and assessments of PTSD.- PTSD in different conditions, groups, and specific incidents.- PTSD in relation to psychotic conditions or assessments.- Peritraumatic stress.- Biochemical, molecular, and genetic aspects of PTSD.- Neurological and neurogenic aspects of PTSD.- PTSD as a risk factor in causation of diseases and pathology.- PTSD in children and adolescents.- Animal models of PTSD: enhancing understanding.- PTSD in international and comparative perspective.- PTSD and selective conditions of stress and anxiety.- Treatments and therapies of PTSD.
  • (source: Nielsen Book Data)9783319083599 20160912
This is an all-embracing reference that offers analyses and discussions of contemporary issues in the field of PTSD. The book brings together scientific material from leading experts in the field relating to a wide range of important current topics across disciplines. These include the early identification of PTSD and subsequent treatment, to social and behavioral studies, to biochemical, molecular and genetic research. With more than 125 chapters organized in 12 major sections, this is the most complete single resource on PTSD.
(source: Nielsen Book Data)9783319083599 20160912
Video
1 online resource (1 streaming video file (48 min.) : color, sound).
  • Contents: Insights into human aging
  • The compression of morbidity: central thesis
  • Reduction in health risks postpones aging
  • Delay aging by lifelong exercise
  • Exercise and morbidity
  • Actions that postpone aging
  • Multiple controlled longitudinal studies.
Video
1 online resource (1 streaming video file (52 min.) : color, sound).
  • Contents: Diversity of vertebrate photoreceptors
  • The eye and circadian biology
  • Retinal degenerate mice
  • Mouse models & photosensitive retinal ganglion cells (pRGCs)
  • The photopigment melanopsin (OPN4) and its ablation
  • Light and pRGCs human studies (regulation of circadian rhythms).
Video
1 online resource (1 streaming video file (31 min.) : color, sound).
  • Contents: Developmental plasticity
  • Genes and environment in development
  • Adaptive developmental decisions and their betrayal if conditions change
  • Phenotypic accommodation
  • Multiple pathways
  • Myth of single gene control
  • Blueprints and programs as false metaphors
  • Cross-generational continuity of the phenotype
  • Origins of novel phenotypes including disease.
Book
1 online resource.
  • Front Cover; Endocrinology of the Heart in Health and Disease; Copyright Page; Contents; List of Contributors; Foreword; Preface; Acknowledgments; I. The Heart as an Endocrine Organ; 1 Cardiac Natriuretic Peptides; Historical Perspective; Gene Structure of Natriuretic Peptides; Atrial Natriuretic Peptide; Brain or B-type Natriuretic Peptide; C-type Natriuretic Peptide; Translation, Processing, and Storage of Cardiac Natriuretic Peptides; Atrial Natriuretic Peptide; Brain or B-Type Natriuretic Peptide; C-Type Natriuretic Peptide
  • Circulating Concentrations, Forms, and Metabolism of Natriuretic PeptidesCirculating Levels; Circulating Forms and Metabolism; Natriuretic Peptide Receptors; Circulating Natriuretic Peptide Signal Peptides; Assays Measuring Natriuretic Peptides in the Circulation; Bioactivity; Hemodynamic; Renal; Endocrine; Integrative Role in Physiology and Pathophysiology; Natriuretic Peptide as Therapeutic Agents; Enhancing Bioactivity; NEP-I; Combined ACE and NEP Inhibitors; Combined ARB and NEP Inhibitors-New Frontier in Heart Failure Therapy; Natriuretic Peptides as Biomarkers in Heart Failure
  • Natriuretic Peptides in Diagnosis of Acute Decompensated Heart FailureBNP and NT-proBNP for Community Screening for Cardiac Impairment; B-Type Natriuretic Peptides for Prognosis in Heart Failure; Marker Guided Therapy in Heart Failure; References; 2 Adrenomedullin; Introduction; Molecular Forms, Structure, and Structure-Activity Relationships of Adrenomedullin; The Adrenomedullin Receptor; Cardiac Actions of Adrenomedullin; Effect of Adrenomedullin on Cardiac Contractility; Effect of Adrenomedullin on Cardiac Structure; Pathophysiological Function of Adrenomedullin in Cardiac Disease
  • Cardiac Hypertrophy and Heart FailureAcute Myocardial Infarction; Ischemia/Reperfusion; Clinical Applications of Adrenomedullin to Cardiac Disease; Effect of Adrenomedullin Administration in Patients with Heart Failure; Clinical Application of Adrenomedullin in Acute Myocardial Infarction; Clinical Trials with Adrenomedullin; Conclusion; References; 3 Endothelin-1 as a Cardiac-Derived Autocrine, Paracrine and Intracrine Factor in Heart Health and Disease; Introduction; Cardiac Production of ET-1; Cardiac ET-1 Production in Heart Disease; Expression of Cardiac ET Receptors
  • Intracellular ET Receptors: Evidence for an Intracrine Role of ET-1 in the Cardiac CellCardiac Effects of ET-1; Mechanisms Underlying Inotropic Responses; Physiological and Pathophysiological Roles of Cardiac-Derived ET-1: General Concepts; ET-1 and the Aging Heart; Association of ET-1 With Cardiac Diseases; ET-1 in Cardiac Hypertrophy and Heart Failure; Endogenous Modulation of ET-1: Keeping ET-1 in Check?; Potential Beneficial Effects of ET-1 in Cardiac Function; Development of Clinical Strategies aimed at Targeting ET-1
Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented. The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds. The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology. * Develops the concept of the heart as both an endocrine organ and an endocrine target, exploring the endocrine function of the heart in both health and disease* Explains how the levels of several cardiac hormones are changed in various cardiac pathologies and how some hormones can be used therapeutically* Offers a single resource on cardio-endocrine disease which collates and curates the wide range of advances being made in the areas of molecular biology, biochemistry, physiology, and pathology.
(source: Nielsen Book Data)9780128031117 20161114
Book
1 online resource (321 p.) Digital: text file; PDF.
  • 1. Jim Davie (backup - Ed Seto-- Moffitt, Florida), U. of Manitoba: General Review of Epigenetics.- 2. Benoit Bruneau (backup - Kunhua Song-- U. of Colorado), UCSF: Chromatin Remodeling in Cardiac Progenitor Cells, Cardiac Development.- 3. Eric Verdin, UCSF: Epigenetics and Metabolism.- 4. Eileen Furlong, EMBL - Heidelberg: Computational Epigenetics.- 5. Eric Olson (backup - Kook-- Korea), UT Southwestern: Role of Class I HDACs in the Heart/Metabolism.- 6. Timothy McKinsey , U. of Colorado: HDACs and HATs in Cardiopulmonary Remodeling.- 7. Johannes Backs, U. of Heidelberg: HDAC Signaling Networks in HF.- 8. Jun Sadoshima , New Jersey: Sirtuins and HF.- 9. Zhi-Ping Liu, UT Southwestern: Histone Methylation in Heart Failure.- 10. C.P. Chang (backup - Bultman-- North Carolina), Stanford: Chromatin Remodeling in Heart Failure.- 11. Sap Halder, Case Western: pTEFb and BET Proteins in Heart Failure.- 12. Norbert Frey, Kiel, Germany: Long Non-Coding RNAs in Heart Failure.- 13. Assam El-Osta, Melbourne, Australia: Chromatin Marks in Heart Failure.- 14. Roger Foo (backup - Meder-- U. of Heidelberg), Singapore: DNA Methylation in Heart Failure.- 15. Joe Hill, UT Southwestern: HDACs and Autophagy in Heart Failure.- 16. Elisabeth Zeisberg (Gottingen) , Gottingen University: Epigenetics Regulation of Fibrosis.- 17. C. Choudhary, U. of Copenhagen: Mass Spectrometry Analysis of the Acetylome.
  • (source: Nielsen Book Data)9783319414553 20170117
This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.
(source: Nielsen Book Data)9783319414553 20170117
Book
1 online resource : illustrations (chiefly color)
  • * Anatomy of the eye and orbit. * Embryology and early development of the eye and adnexia. * Genetics. * Biochemistry and cell biology. * Physiology of vision and the visual system. * General and ocular pharmacology. * Immunology. * Microbiology and infection. * Pathology.* Index.
  • (source: Nielsen Book Data)9780702055546 20160618
The Eye: Basic Sciences in Practice provides highly accessible, concise coverage of all the essential basic science required by today's ophthalmologists and optometrists in training. It is also essential reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area. This new fourth edition has now been fully revised and updated in line with current curricula, key research developments and clinical best practice. It succinctly incorporates the massive strides being made by genetics and functional genomics based on the Human Genome Project, the new understanding of how the microbiome affects all aspects of immunology, the remarkable progress in imaging technology now applied to anatomy and neurophysiology, as well as exciting new molecular and other diagnostic methodologies now being used in microbiology and pathology. All this and more collectively brings a wealth of new knowledge to students and practitioners in the fields of ophthalmology and visual science. For the first time, this (print) edition also now comes with bonus access to the complete, fully searchable electronic text - including carefully selected additional information and new video content to further explain and expand on key concepts - making The Eye a more flexible, comprehensive and engaging learning package than ever before.
(source: Nielsen Book Data)9780702055546 20160618
Book
1 online resource (xxii, 585 pages) : illustrations (some color). Digital: text file; PDF.
  • Part I. Introduction to Fractal Geometry and its Applications to Neurosciences
  • The Fractal Geometry of the Brain: An Overview
  • 2. Box-Counting Fractal Analysis: A Primer for the Clinician
  • Tenets and Methods of Fractal Analysis (1/f noise)
  • 4. Tenets, Methods and Applications of Multifractal Analysis in Neurosciences
  • Part II. Fractals in Neuroanatomy and Basic Neurosciences
  • Fractals in Neuroanatomy and Basic Neurosciences: An Overview
  • Morphology and Fractal-Based Classifications of Neurons and Microglia
  • The Morphology of the Brain Neurons: Box-counting Method in Quantitative Analysis of 2D Image
  • Neuronal Fractal Dynamics
  • Does a Self-Similarity Logic Shape the Organization of the Nervous System?
  • Fractality of Cranial Sutures
  • The Fractal Geometry of the Human Brain: An Evolutionary Perspective
  • Part III. Fractals in Clinical Neurosciences
  • Fractal Analysis in Clinical Neurosciences: An Overview
  • Fractal Analysis in Neurological Diseases
  • Fractal Dimension Studies of the Brain Shape in Aging and Neurodegenerative Diseases
  • Fractal Analysis in Neurodegenerative Diseases
  • Fractal Analysis of the Cerebrovascular System Physiopathology
  • Fractal and Chaos in the Hemodynamics of Intracranial Aneurysms
  • Fractal-based Analysis of Arteriovenous Malformations (AVMs)
  • Fractals in Neuroimaging
  • Computational Fractal-Based Analysis of MR Susceptibility Weighted Imaging (SWI) in Neuro-oncology and neurotraumatology
  • Texture Estimation for Abnormal Tissue Segmentation in Brain MRI
  • Tumor Growth in the Brain: Complexity and Fractality
  • Histological Fractal-based Classification of Brain Tumors
  • Computational Fractal-based Analysis of the Brain Tumors Microvascular Networks
  • Fractal analysis of electroencephalographic time-series (EEG-signals)
  • On Multiscaling of Parkinsonian Rest Tremor Signals and Their Classification
  • Fractals and Electromyograms
  • Fractal analysis in Neuro-ophthalmology
  • Fractals in Affective and Anxiety Disorders
  • Fractal Fluency: An Intimate Relationship Between the Brain and Processing of Fractal Stimuli
  • Part IV. Computational Fractal-Based Neurosciences
  • Computational Fractal-based Neurosciences: An Overview
  • ImageJ in Computational Fractal-based Neuroscience: Pattern Extraction and Translational Research
  • Fractal Analysis in MATLAB: A Tutorial for Neuroscientists
  • Methodology to Increase the Computational Speed to Obtain the Fractal Dimension Using GPU Programming
  • Fractal Electronics as a Generic Interface to Neurons
  • Fractal Geometry meets Computational Intelligence: Future Perspectives.
Reviews the most intriguing applications of fractal analysis in neuroscience with a focus on current and future potential, limits, advantages, and disadvantages. Will bring an understanding of fractals to clinicians and researchers also if they do not have a mathematical background, and will serve as a good tool for teaching the translational applications of computational models to students and scholars of different disciplines. This comprehensive collection is organized in four parts: (1) Basics of fractal analysis; (2) Applications of fractals to the basic neurosciences; (3) Applications of fractals to the clinical neurosciences; (4) Analysis software, modeling and methodology.
Book
1 online resource (XIII, 115 p. 30 ill., 17 illus. in color.) : online resource. Digital: text file; PDF.
  • Introduction to NeuroIS.- A Primer on Neurobiology and the Brain for Information Systems Scholars.- Tools in NeuroIS Research: An Overview.- Topics in NeuroIS and a Taxonomy of Neuroscience Theories in NeuroIS.- quot--Times New Roman"--mso-ansi-language:EN-CA--mso-fareast-language:DE--mso-bi di-language: AR-SA">Establishing and Operating a NeuroIS Lab.
  • (source: Nielsen Book Data)9783662450901 20160619
This authored volume presents the fundamentals of NeuroIS, which is an emerging subfield within the Information Systems discipline that makes use of neuroscience and neurophysiological tools and knowledge to better understand the development, use, and impact of information and communication technologies. This book is an initial guide to this new research domain. The target audience primarily comprises PhD students and researchers, but the book may also be beneficial for graduate students and practitioners.
(source: Nielsen Book Data)9783662450901 20160619
Video
1 online resource (1 streaming video file (40 min.) : color, sound).
  • Contents: Complexity of the lung cancer genome
  • Molecular classification of subtypes
  • Pathways of activation in tumors
  • Intratumoral heterogeneity
  • Targetable alterations in patients
  • Emerging areas in genomics of lung cancer.
Video
1 online resource (1 streaming video file (45 min.) : color, sound).
  • Contents: Life phases and human senescent phenotypes
  • Seven major human senescence phenotypes
  • Hypertension
  • Atherosclerosis
  • Alzheimer's disease
  • Diabetes type 2
  • Muscle aging
  • Gastrointestinal cancers
  • Skin aging
  • Inflammasomes and aging.
Book
1 online resource (viii, 333 p.) Digital: text file; PDF.
  • The Mechanophysiololgy of Stress Fractures in Military Recruits.- Traumatic Brain Injury in the Military: Biomechanics and Finite Element Modelling.- Modeling Skeletal Injuries in Military Scenarios.- Biomechanics of Eye Injury in the Military.- The Biomechanical Basis for Increased Risk of Overuse Musculoskeletal Injuries in Female Soldiers.
  • (source: Nielsen Book Data)9783319330105 20160619
This book provides a state-of-the-art update, as well as perspectives on future directions of research and clinical applications in the implementation of biomechanical and biophysical experimental, theoretical and computational models which are relevant to military medicine. Such experimental and modeling efforts are helpful, on the one hand, in understanding the aetiology, pathophysiology and dynamics of injury development and on the other hand in guiding the development of better equipment and protective gear or devices that should ultimately reduce the prevalence and incidence of injuries or lessen their hazardous effects. The book is useful for military-oriented biomedical engineers and medical physicists, as well as for military physiologists and other medical specialists who are interested in the science and technology implemented in modern investigations of military related injuries.
(source: Nielsen Book Data)9783319330105 20160619
Book
1 online resource ()
  • Front Cover; Molecular Basis of Nutrition and Aging; Copyright Page; Contents; List of Contributors; Introduction to the Molecular Basis of Nutrition and Aging; Series Preface; Acknowledgments; I. Introductory Aspects on Aging and Nutrition; 1 Molecular and Cellular Basis of Aging; Introduction; Biological Principles of Aging; Occurrence, Accumulation, and Consequences of Molecular Damage; Homeodynamics and the Homeodynamic Space; Nutrition and Food for Aging Interventions; Nutritional Hormetins; Conclusions; Summary Points; References.
  • 2 Unraveling Stochastic Aging Processes in Mouse Liver: Dissecting Biological from Chronological AgeIntroduction; Pathological Parameters are only Partially Associated with Chronological Age; Intraorgan Specific Biological Phenotypes; Tissue-Specific Biological Phenotypes; Gene Expression Profiles Related to Pathological Aging Parameters; Gene Expression Profiles Correlating with Pathological Parameters are Largely Specific to the Pathological Parameters; Future Perspectives; Conclusion; References; 3 Nutrigenomics and Nutrigenetics: The Basis of Molecular Nutrition; Introduction.
  • Nutrigenetics of Omega-3 PUFA in CVDNutrigenetics of Omega-3 PUHA in Cancer; DNA Damage and Nutrients; Cellular Senescence and Nutrients; Epigenetics and Nutrients; Summary Points; References; 4 Diet and Longevity Phenotype; Introduction; Main Text; Nutrient Components and Aging Process; Crucial Role of Fatty Acid Component; Genomic Studies and Importance of Palmitoleic Acid; The Central Position of Energy Sensor Systems; The Involvement of Sympathetic System; Epigenetic Linkage of Aging and Nutrition; Summary; References; 5 Nutrition in the Elderly: General Aspects; Introduction.
  • Malnutrition in the Elderly: Definition and General AspectsCauses of Malnutrition in the Elderly; Malnutrition: Possible Correction With Supplements in the Elderly; Nutrient-Sensing Pathways; Nutrient-Gene Interaction in the Elderly (Nutrigenomic Approach); Conclusions and Perspectives; Summary Points; Acknowledgments; References; 6 Nutrition in the Hospitalized Elderly; Introduction; Pathogenesis of Malnutrition in Hospitalized Elderly; The Interaction Between Aging, Health Status, Hospital Environment, and Nutritional Status; Why Are Hospitalized Older Adults Nutritionally Vulnerable?
  • Age-Related ChangesAnorexia of Aging; Changes in the Body Composition; Taste, Smell, and Mastication Dysfunction; Gastrointestinal Changes; Medical Causes; Use of Multiple Medications; Functional and Psychosocial Factors; Hospital Environment-Related Risks; Clinical Consequences of Malnutrition in Hospital; Malnutrition Screening and Assessment in Hospitalized Elderly; Malnutrition Screening as a Part from Comprehensive Geriatric Assessment (CGA); Comprehensive Nutritional Assessment; Nutritional History; Physical and Clinical Assessment; Anthropometry; The Biochemical Investigations.