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Book
1 online resource (353 pages).
  • Contributors x Preface xiii Biography of Martin Kussmann xiv Section I Genes, Proteins, and Nutrition 1 1 The use of transcriptomics as a tool to identify differences in the response to diet 3 Juri C. Matualatupauw and Lydia A. Afman 1.1 New concepts in nutrition research 3 1.2 Comprehensive phenotyping 3 1.3 Phenotypic flexibility 4 1.4 Factors that influence the transcriptome response to diet 5 1.5 Using transcriptomics to explain mechanism behind differences in response to diet 10 1.6 Conclusion 10 1.7 Future perspectives 15 References 16 2 Genetic or nutritional disturbances in folate ]related pathways and epigenetic interactions 19 Daniel Leclerc and Rima Rozen 2.1 Introduction 19 2.2 Nutrition and one ]carbon metabolism 20 2.3 Importance of DNAmethylation at CpG dinucleotides 23 2.4 Folate ]dependent disorders: Dietary impact 24 2.5 Genetic influences on phenotype and interactions with epigenetics 27 2.6 Epigenetic inheritance across generations 31 2.7 Conclusions 34 References 35 3 Early ]life development and epigenetic mechanisms: Mediators of metabolic programming and obesity risk 42 Felicia M. Low, Peter D. Gluckman, and Keith M. Godfrey 3.1 Introduction 42 3.2 Origins of DOHaD and its conceptual basis 43 3.3 Epigenetic mechanisms 44 3.4 Early ]life nutrition, epigenetics, and metabolic programming 48 3.5 Paternal effects 52 3.6 Transgenerational epigenetic inheritance 54 3.7 The potential value of DOHaD principles and epigenetic biology to the improvement of human health 55 3.8 Conclusion 57 Acknowledgments 57 References 58 Section II Bioactives and Phytonutrients 65 4 Bioactive interactions in food and natural extracts 67 Sofia Moco and Denis Barron 4.1 Natural compounds as all compounds produced by nature 67 4.2 Not all natural compounds are created active 70 4.3 On the road of modern technologies for bioactive discovery 71 4.4 Metabolomics strategies applied to bioactives biochemistry 77 4.5 Bioactives as multi ]target network instigators 81 4.6 Let food be thy medicine and medicine be thy food outlook 85 Acknowledgments 85 References 85 5 Anthocyanins in metabolic health and disease 92 John Overall, Mary Ann Lila, and Slavko Komarnytsky 5.1 Introduction 92 5.2 Chemical structure 93 5.3 Structural effects on stability 93 5.4 Systemic bioavailability and tissue distribution 96 5.5 Metabolism and nutrigenomic effects 102 5.6 Conclusions 114 Acknowledgments 114 References 114 6 Dietary antioxidants and bioflavonoids in atherosclerosis and angiogenesis 125 Mohsen Meydani and Angelo Azzi 6.1 Introduction 125 6.2 Dietary vitamins E and C and CVD 126 6.3 Dietary polyphenols and CVD 128 6.4 Flavonoids and angiogenesis 134 6.5 Conclusion 135 Acknowledgments 136 References 137 7 Genomics and proteomics approaches to identify resveratrol targets in cancer 143 Cesar Lopez ]Camarillo, Rubiceli Medina ]Aguilar, Carlos Palma ]Flores, and Laurence A. Marchat 7.1 Introduction 143 7.2 Sources and health benefits of resveratrol 144 7.3 Resveratrol for cancer prevention and therapy 145 7.4 Functional genomics approaches to identify resveratrol targets in cancer 147 7.5 Proteomics approaches to identify resveratrol targets in cancer 148 7.6 Metabolomics approaches to identify pathways modified by resveratrol in cancer 150 7.7 Epigenomic events induced by resveratrol in cancer 152 7.8 Conclusions and perspectives 153 References 153 8 Genomic effects of food bioactives in neuroprotection 156 Ashraf Virmani, Syed Ali, Luigi Pinto, Saf Zerelli, and Zbigniew Binienda 8.1 Introduction: Nature and nurture 156 8.2 Mechanism underlying food nurture 156 8.3 Natural cellular nurture mechanisms 157 8.4 Effects of food bioactives on genomic activity 158 8.5 Epigenetic modulation 158 8.6 Modulation of the epigenome by food bioactives 159 8.7 Possible role of the genome in neuroprotection 160 8.8 Countering risk factors associated with neurodegeneration 161 8.9 Using food bioactives to restore epigenetic balance 161 8.10 Targeting inflammation, energy, and free radicals 161 8.11 Food bioactives that reduce inflammation 163 8.12 Food bioactive effects on bioenergetics and redox balance 163 8.13 Role of food bioactive acetyl ]l ]carnitine in neurodegeneration 163 8.14 Process of S ]palmitoylation and the role of carnitine palmitoyltransferase 1c enzyme in the brain 164 8.15 Conclusion 164 References 165 9 MicroRNAs: Bioactive molecules at the nexus of nutrition and disease 170 Lisa M. Farmer and Kendal D. Hirschi 9.1 Introduction to micro RNAs as dietary bioactive compounds 170 9.2 Characteristics, biogenesis, and functions of miRNAs 171 9.3 miRNA detection methods 173 9.4 Small RNAs in the circulation 174 9.5 Endogenous miRNAs and metabolic control 176 9.6 miRNAs as biomarkers for diet and disease 178 9.7 Absorption of dietary animal miRNAs in animal consumers 184 9.8 Absorption of dietary plant miRNAs in animal consumers 185 9.9 Contradictory evidence of dietary miRNA uptake 188 9.10 Therapeutic potential of miRNAs 190 9.11 Gut pathology may influence dietary miRNA uptake 191 9.12 Conclusion 193 Acknowledgments 195 References 195 Section III Prebiotics, Probiotics, Synbiotics, and the Gut Ecosystem 201 10 Gut health and the personal microbiome 203 Carolin A. Kolmeder and Willem M. de Vos 10.1 Gut health and its concepts 203 10.2 Microbiome and gut health from composition to function 206 10.3 The personalized microbiome towards precision nutrition 211 10.4 Conclusions and next ]generation interventions 214 Acknowledgments 215 References 215 11 Infant nutrition and the microbiome: Systems biology approaches to uncovering host microbe interactions 220 Mei Wang, Ivan Ivanov, Laurie A. Davidson, Robert S. Chapkin, and Sharon M. Donovan 11.1 Introduction 220 11.2 Environmental factors influencing development of the infant gut microbiota 221 11.3 Infant nutrition and the development of gut microbiota 223 11.4 Host genetics and the development of gut microbiota 226 11.5 Host microbe interactions regulating host phenotype and gene expression 230 11.6 Systems biology approaches to diet ]dependent host microbe interaction 243 11.7 Summary and conclusions 247 References 247 12 Bioactive host microbial metabolites in human nutrition with a focus on aromatic amino acid co ]metabolism 258 Francois ]Pierre J. Martin and Martin Kussmann 12.1 Introduction: Gut microbiota metabolism in nutrition, health and disease 258 12.2 Short ]chain fatty acid metabolism 259 12.3 Bile acid metabolism 260 12.4 Aromatic amino acid metabolism 261 12.5 Conclusions and perspectives 269 References 270 Section IV Nutrigenomic and Proteomic Technologies 275 13 Network analysis in systems nutrition 277 Marie ]Pier Scott-Boyer and Corrado Priami 13.1 Introduction 277 13.2 Biological networks 278 13.3 Network topology 281 13.4 A general framework for network analysis of throughput data 282 13.5 Examples of network analyses 284 13.6 Conclusions and perspectives 286 References 287 14 Nutrigenomics analyses: Biostatistics and systems biology approaches 290 Damien Valour and Bernard Valour 14.1 Gene selection for nutrigenomics studies 290 14.2 Specificity of high ]dimension data and preprocessing before gene selection 291 14.3 Exploratory and differential gene expression analysis 292 14.4 Biomarker discovery in nutrigenomics: Gene selection and discrimination 297 14.5 A step towards data integration: searching for correlation/covariance between two datasets 310 14.6 From gene selection to systems biology 313 References 315 Index 319.
  • (source: Nielsen Book Data)9781119098836 20180709
Now in a revised second edition, Nutrigenomics and Proteomics in Health and Disease brings together the very latest science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals and their impact on gene interaction and health. Authored by an international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date. Thoroughly updated to reflect the most current developments in the field, the second edition includes six new chapters covering gut health and the personal microbiome; gut microbe-derived bioactive metabolites; proteomics and peptidomics in nutrition; gene selection for nutrigenomic studies; gene-nutrient network analysis, and nutrigenomics to nutritional systems biology. An additional five chapters have also been significantly remodelled. The new text includes a rethinking of in vitro and in vivo models with regard to their translatability into human phenotypes, and normative science methods and approaches have been complemented by more comprehensive systems biology-based investigations, deploying a multitude of omic platforms in an integrated fashion. Innovative tools and methods for statistical treatment and biological network analysis are also now included.
(source: Nielsen Book Data)9781119098836 20180709
Book
1 online resource.
  • Contributors x Preface xiii Biography of Martin Kussmann xiv Section I Genes, Proteins, and Nutrition 1 1 The use of transcriptomics as a tool to identify differences in the response to diet 3 Juri C. Matualatupauw and Lydia A. Afman 1.1 New concepts in nutrition research 3 1.2 Comprehensive phenotyping 3 1.3 Phenotypic flexibility 4 1.4 Factors that influence the transcriptome response to diet 5 1.5 Using transcriptomics to explain mechanism behind differences in response to diet 10 1.6 Conclusion 10 1.7 Future perspectives 15 References 16 2 Genetic or nutritional disturbances in folate ]related pathways and epigenetic interactions 19 Daniel Leclerc and Rima Rozen 2.1 Introduction 19 2.2 Nutrition and one ]carbon metabolism 20 2.3 Importance of DNAmethylation at CpG dinucleotides 23 2.4 Folate ]dependent disorders: Dietary impact 24 2.5 Genetic influences on phenotype and interactions with epigenetics 27 2.6 Epigenetic inheritance across generations 31 2.7 Conclusions 34 References 35 3 Early ]life development and epigenetic mechanisms: Mediators of metabolic programming and obesity risk 42 Felicia M. Low, Peter D. Gluckman, and Keith M. Godfrey 3.1 Introduction 42 3.2 Origins of DOHaD and its conceptual basis 43 3.3 Epigenetic mechanisms 44 3.4 Early ]life nutrition, epigenetics, and metabolic programming 48 3.5 Paternal effects 52 3.6 Transgenerational epigenetic inheritance 54 3.7 The potential value of DOHaD principles and epigenetic biology to the improvement of human health 55 3.8 Conclusion 57 Acknowledgments 57 References 58 Section II Bioactives and Phytonutrients 65 4 Bioactive interactions in food and natural extracts 67 Sofia Moco and Denis Barron 4.1 Natural compounds as all compounds produced by nature 67 4.2 Not all natural compounds are created active 70 4.3 On the road of modern technologies for bioactive discovery 71 4.4 Metabolomics strategies applied to bioactives biochemistry 77 4.5 Bioactives as multi ]target network instigators 81 4.6 Let food be thy medicine and medicine be thy food outlook 85 Acknowledgments 85 References 85 5 Anthocyanins in metabolic health and disease 92 John Overall, Mary Ann Lila, and Slavko Komarnytsky 5.1 Introduction 92 5.2 Chemical structure 93 5.3 Structural effects on stability 93 5.4 Systemic bioavailability and tissue distribution 96 5.5 Metabolism and nutrigenomic effects 102 5.6 Conclusions 114 Acknowledgments 114 References 114 6 Dietary antioxidants and bioflavonoids in atherosclerosis and angiogenesis 125 Mohsen Meydani and Angelo Azzi 6.1 Introduction 125 6.2 Dietary vitamins E and C and CVD 126 6.3 Dietary polyphenols and CVD 128 6.4 Flavonoids and angiogenesis 134 6.5 Conclusion 135 Acknowledgments 136 References 137 7 Genomics and proteomics approaches to identify resveratrol targets in cancer 143 Cesar Lopez ]Camarillo, Rubiceli Medina ]Aguilar, Carlos Palma ]Flores, and Laurence A. Marchat 7.1 Introduction 143 7.2 Sources and health benefits of resveratrol 144 7.3 Resveratrol for cancer prevention and therapy 145 7.4 Functional genomics approaches to identify resveratrol targets in cancer 147 7.5 Proteomics approaches to identify resveratrol targets in cancer 148 7.6 Metabolomics approaches to identify pathways modified by resveratrol in cancer 150 7.7 Epigenomic events induced by resveratrol in cancer 152 7.8 Conclusions and perspectives 153 References 153 8 Genomic effects of food bioactives in neuroprotection 156 Ashraf Virmani, Syed Ali, Luigi Pinto, Saf Zerelli, and Zbigniew Binienda 8.1 Introduction: Nature and nurture 156 8.2 Mechanism underlying food nurture 156 8.3 Natural cellular nurture mechanisms 157 8.4 Effects of food bioactives on genomic activity 158 8.5 Epigenetic modulation 158 8.6 Modulation of the epigenome by food bioactives 159 8.7 Possible role of the genome in neuroprotection 160 8.8 Countering risk factors associated with neurodegeneration 161 8.9 Using food bioactives to restore epigenetic balance 161 8.10 Targeting inflammation, energy, and free radicals 161 8.11 Food bioactives that reduce inflammation 163 8.12 Food bioactive effects on bioenergetics and redox balance 163 8.13 Role of food bioactive acetyl ]l ]carnitine in neurodegeneration 163 8.14 Process of S ]palmitoylation and the role of carnitine palmitoyltransferase 1c enzyme in the brain 164 8.15 Conclusion 164 References 165 9 MicroRNAs: Bioactive molecules at the nexus of nutrition and disease 170 Lisa M. Farmer and Kendal D. Hirschi 9.1 Introduction to micro RNAs as dietary bioactive compounds 170 9.2 Characteristics, biogenesis, and functions of miRNAs 171 9.3 miRNA detection methods 173 9.4 Small RNAs in the circulation 174 9.5 Endogenous miRNAs and metabolic control 176 9.6 miRNAs as biomarkers for diet and disease 178 9.7 Absorption of dietary animal miRNAs in animal consumers 184 9.8 Absorption of dietary plant miRNAs in animal consumers 185 9.9 Contradictory evidence of dietary miRNA uptake 188 9.10 Therapeutic potential of miRNAs 190 9.11 Gut pathology may influence dietary miRNA uptake 191 9.12 Conclusion 193 Acknowledgments 195 References 195 Section III Prebiotics, Probiotics, Synbiotics, and the Gut Ecosystem 201 10 Gut health and the personal microbiome 203 Carolin A. Kolmeder and Willem M. de Vos 10.1 Gut health and its concepts 203 10.2 Microbiome and gut health from composition to function 206 10.3 The personalized microbiome towards precision nutrition 211 10.4 Conclusions and next ]generation interventions 214 Acknowledgments 215 References 215 11 Infant nutrition and the microbiome: Systems biology approaches to uncovering host microbe interactions 220 Mei Wang, Ivan Ivanov, Laurie A. Davidson, Robert S. Chapkin, and Sharon M. Donovan 11.1 Introduction 220 11.2 Environmental factors influencing development of the infant gut microbiota 221 11.3 Infant nutrition and the development of gut microbiota 223 11.4 Host genetics and the development of gut microbiota 226 11.5 Host microbe interactions regulating host phenotype and gene expression 230 11.6 Systems biology approaches to diet ]dependent host microbe interaction 243 11.7 Summary and conclusions 247 References 247 12 Bioactive host microbial metabolites in human nutrition with a focus on aromatic amino acid co ]metabolism 258 Francois ]Pierre J. Martin and Martin Kussmann 12.1 Introduction: Gut microbiota metabolism in nutrition, health and disease 258 12.2 Short ]chain fatty acid metabolism 259 12.3 Bile acid metabolism 260 12.4 Aromatic amino acid metabolism 261 12.5 Conclusions and perspectives 269 References 270 Section IV Nutrigenomic and Proteomic Technologies 275 13 Network analysis in systems nutrition 277 Marie ]Pier Scott-Boyer and Corrado Priami 13.1 Introduction 277 13.2 Biological networks 278 13.3 Network topology 281 13.4 A general framework for network analysis of throughput data 282 13.5 Examples of network analyses 284 13.6 Conclusions and perspectives 286 References 287 14 Nutrigenomics analyses: Biostatistics and systems biology approaches 290 Damien Valour and Bernard Valour 14.1 Gene selection for nutrigenomics studies 290 14.2 Specificity of high ]dimension data and preprocessing before gene selection 291 14.3 Exploratory and differential gene expression analysis 292 14.4 Biomarker discovery in nutrigenomics: Gene selection and discrimination 297 14.5 A step towards data integration: searching for correlation/covariance between two datasets 310 14.6 From gene selection to systems biology 313 References 315 Index 319.
  • (source: Nielsen Book Data)9781119098836 20180709
Now in a revised second edition, Nutrigenomics and Proteomics in Health and Disease brings together the very latest science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals and their impact on gene interaction and health. Authored by an international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date. Thoroughly updated to reflect the most current developments in the field, the second edition includes six new chapters covering gut health and the personal microbiome; gut microbe-derived bioactive metabolites; proteomics and peptidomics in nutrition; gene selection for nutrigenomic studies; gene-nutrient network analysis, and nutrigenomics to nutritional systems biology. An additional five chapters have also been significantly remodelled. The new text includes a rethinking of in vitro and in vivo models with regard to their translatability into human phenotypes, and normative science methods and approaches have been complemented by more comprehensive systems biology-based investigations, deploying a multitude of omic platforms in an integrated fashion. Innovative tools and methods for statistical treatment and biological network analysis are also now included.
(source: Nielsen Book Data)9781119098836 20180709
Book
1 online resource (234 p.) : ill. (some col.).
"Epigenetics is emerging as an important factor in risk of diseases of global importance including obesity, cardiovascular disease and cancer. Unlike gene polymorphisms which have been the focus of understanding the role of inherited disease susceptibility for some time, epigenetic can be modified by environmental factors, in particular nutrition. Thus research into the role of epigenetics in disease has substantial potential for explaining the impact of the environmental factors such as diet on disease risk. Since epigenetic processes can be modified by nutrition, it may be possible to modify inappropriate epigenetic marks by nutritional interventions to reduce disease risk. This book will explore current understanding of the interaction between nutrition, epigenetics and disease risk, will place this knowledge in the context of global health and discuss the ethical implications of this research."--Publisher's website.

4. Nutrigenomics [2016]

Book
1 online resource (xxi, 222 pages) : illustrations (some color)
Book
xix, 404 pages : illustrations ; 24 cm.
  • Series Preface Preface Editors Contributors Fetal Programming Early-Life Exposures and the Epigenome: Interactions between Nutrients and the Environment-- Elizabeth H. Marchlewicz, Olivia S. Anderson, and Dana C. Dolinoy Maternal Diet and Exercise: Influences on Obesity and Insulin Resistance-- Lindsay G. Carter, Kellie L. K. Tamashiro, and Kevin J. Pearson Maternal Protein and Fat Intake: Epigenetic Consequences on Fetal Development-- Yuan-Xiang Pan, Rita S. Strakovsky, Dan Zhou, Huan Wang, and Hong Chen Methyl Donors Folate, DNA Methylation, and Colorectal Cancer-- Sung-Eun Kim, Shannon Masih, and Young-In Kim Parental Nutrition, Epigenetics, and Chronic Disease-- Julia A. Sabet, Eric D. Ciappio, and Jimmy W. Crott Alcohol and DNA Methylation-- Silvia Udali, Simonetta Friso, and Sang-Woon Choi Other Essential Nutrients Ascorbate as a Modulator of the Epigenome-- Nilay Y. Thakar and Ernst J. Wolvetang Epigenetic Regulation of Cellular Responses toward Vitamin D-- Prashant K. Singh and Moray J. Campbell Role of Iron in Epigenetic Regulation of Gene Expression-- Laura Cartularo and Max Costa Selenium and Epigenetic Effects on Histone Marks and DNA Methylation-- Wen-Hsing Cheng, Meltem Muftuoglu, and Ryan T. Y. Wu Proline: Metabolic Sensing and Parametabolic Regulation-- James M. Phang, Wei Liu, Chad Hancock, and Meredith Harman Dietary Effects on Adipocyte Metabolism and Epigenetics-- Kate J. Claycombe, Huawei Zeng, and Gerald F. Combs, Jr. Phytochemicals Epigenetics of BRCA-1-Related Breast Tumorigenesis and Dietary Prevention-- Donato F. Romagnolo and Ornella I. Selmin Regulation of Histone Acyltransferases and Deacetylases by Bioactive Food Compounds for the Prevention of Chronic Diseases-- Tho X. Pham and Ji-Young Lee Index.
  • (source: Nielsen Book Data)9781482203813 20160617
Nutrition and Epigenetics presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors modulate the epigenome and affect development processes, chronic disease, and the aging process. This pivotal text: * Documents the epigenetic effect of antioxidants and their health benefits * Adds to the understanding of mechanisms leading to disease susceptibility and healthy aging * Illustrates that the epigenetic origins of disease occur in early (fetal) development * Synthesizes the data regarding nutrient and epigenomic interactions Nutrition and Epigenetics highlights the interactions among nutrients, epigenetics, and health, providing an essential resource for scientists and clinical researchers interested in nutrition, aging, and metabolic diseases.
(source: Nielsen Book Data)9781482203813 20160617
Science Library (Li and Ma)
Book
xiv, 233 pages ; 21 cm
Vegan, low fat, low carb, slow carb: Every diet seems to promise a one-size-fits-all solution to health. But they ignore the diversity of human genes and how they interact with what we eat. In Food, Genes, and Culture, renowned ethnobotanist Gary Nabhan shows why the perfect diet for one person could be disastrous for another. If your ancestors were herders in Northern Europe, milk might well provide you with important nutrients, whereas if you're Native American, you have a higher likelihood of lactose intolerance. If your roots lie in the Greek islands, the acclaimed Mediterranean diet might save your heart; if not, all that olive oil could just give you stomach cramps. Nabhan traces food traditions around the world, from Bali to Mexico, uncovering the links between ancestry and individual responses to food. The implications go well beyond personal taste. Today's widespread mismatch between diet and genes is leading to serious health conditions, including a dramatic growth over the last 50 years in auto-immune and inflammatory diseases. Readers will not only learn why diabetes is running rampant among indigenous peoples and heart disease has risen among those of northern European descent, but may find the path to their own perfect diet.
(source: Nielsen Book Data)9781610914925 20160617
SAL3 (off-campus storage)
Book
1 online resource (xi, 384 p.) : ill.
"Nutrigenetics: Applying the Science of Personal Nutrition" provides a fully referenced, readable guide to understanding the rationale and importance of nutrigenetic applications and explains why single nutrition recommendations will not fit everybody or even a majority of modern humans. This books explains how genetic variation shapes individual nutrition requirements and sensitivities, presents questions to ask about reported gene-nutrient interactions, and what needs to be done before putting nutrigenetic tests to practical use. This book blends key concepts from the fields of genetics, biochemistry, epidemiology, public health, and clinical medicine to give a rich perspective on the genetically diverse nutritional needs and sensitivities of individuals in health and disease. A steadily increasing number of people order genetic tests to find out what they should eat for better health, well being and performance, and an even greater number asks their healthcare providers about such tests. Most of the currently offered tests are not grounded in current knowledge, often absurdly so, but few professionals can explain why they are misguided. On the other hand, there are more evidence-supported genetic variants that can guide nutrition decisions, but again most healthcare providers know little about them, much less use them in their daily practice. There is a great need for a solidly evidence-based yet accessible book that explains the science of nutrigenetics and provides the tools to evaluate new nutrigenetic tests. It includes comprehensive coverage of the emerging science of nutritional genetics and its promise for individually tailored nutrition guidance. It presents practical examples to enhance comprehension and spur additional research. It offers a logical progression from what nutrigenetics is, to its possibilities in enhancing health.
(source: Nielsen Book Data)9780123859006 20160615
Video
1 online resource (1 streaming video file (29 min.) : color, sound).
  • Contents: Nutrition and evolution of brain development
  • Human diversity
  • Salivary amylase and starch digestion
  • Positive selection of lactase persistence
  • Food globalization
  • The diet-heart connection: nature versus nurture
  • Health disparities
  • Genetic predisposition
  • Gene-environment interactions.
Book
xxi, 426 p. : ill.
  • TRANSFORMING DIETARY SIGNALS INTO GENE EXPRESSIONEpigenetics: The Epigenetic Transfer of Phenotype Epigenetics: Molecular Targets for Diet and Cancer Prevention, Sharon A. RossDiet-influenced Chromatin Modification and Expression of Chemopreventive Genes by the Soy Peptide, Lunasin, Alfredo F. Galvez, Liping Huang, Mark J.M. Magbanua, Kevin Dawson, Somen Nandi and Raymond L. RodriguezRole of Epigenetics in the Complications Associated with Diabetes and Related Metabolic Disorders, Louisa M. Villevenuve and Rama NatarajanSystems Biology: Cell Signaling Regulation of Gene ExpressionSystems Biology Approaches to Study Diet x Genome Interactions, Xia Yang, Zhidong Tu and Jun ZhuModulation of Atherosclerosis by N-3 Polyunsaturated Fatty Acids, Darshan S. Kelley, Yuriko Adkins, Sumeet Sharma, Dawn M. FedorNutrigenomic Implications for Nuclear Receptor Coactivators, David M. Lonard and Bert W. O'MalleyNutrigenomics of Fatty Acid Sensing, Sander KerstenThe Polyphenol Resveratrol Alters Global Patterns of Gene Regulation and Improves Physiology Through Multiple Potential Pathways, Behzad Varamini and Joseph A. BaurNutritional Genomics: Cellular Signaling and Molecular Targets, Wayne R. BidlackGENE LINKED NETWORKSGene Linked Chronic DiseaseMechanisms Mediating Obesity-Induced Inflammation and Insulin Resistance, Simon Schenk, Olivia Osborn and Jerrold M. OlefskyNutritional Genomics of Vitamin D on Cardiovascular Disease, Sandra F. Williams, Jorge N. Artaza and Keith C. NorrisGene Linked Cancer PreventionNetwork Analysis of Gene Expression Profiles in Breast Cancer Cell Lines, T. Gregory Dewey, Katie L. Streicher and Stephen P. EthierEffects of Dietary Effectors on Signal Transduction Pathways Related to Cancer Prevention, Ann M. Bode and Zigang DongGreen Tea Polyphenols, DNA Repair and Prevention of Photocarcinogenesis, Santosh K. KatiyarBioactive Food Components and the "U" Shaped Health Conundrum: Vitamin D and Folate as Examples of Friends and Foes, John A. MilnerIntestinal Microbiome Linked Gene ExpressionHuman Intestinal Microbiome: Etiology of Inflammation Genomics, Roger A. ClemensFOOD NEEDS TO MEET NUTRIGENOMIC HEALTH NEEDSAgriculture's Ability to Enhance Food QualityCalcium Biofortification of Crops, Kendal D. Hirschi and Sean M. ThompsonThe Use of Genomics-Aided Breeding to Improve the Nutritional Content of Lettuce, David W. StillFood Science and Technology Enhancement of Diet qualityNatural Colorants as Bioactive Agents in Functional Foods, Ann Marie CraigManufacturing Functional Foods: Effects on Quality and Bioavailability, Ryan J. Elijas and John D. FlorosNew Whole Foods Designed to Deliver Bioactive Components, Cheryl MitchellRegulatory OversightNutritional Genomics and the Future of Food Labeling in the US, Evelyn D. CadmanIndex.
  • (source: Nielsen Book Data)9781439844533 20171218
The notion of matching diet with an individual's genetic makeup is transforming the way the public views nutrition as a means of managing health and preventing disease. To fulfill the promise of nutritional genomics, researchers are beginning to reconcile the diverse properties of dietary factors with our current knowledge of genome structure and gene function. What is emerging is a complex system of interactions that make the human genome exquisitely sensitive to our nutritional environment. Nutritional Genomics: The Impact of Dietary Regulation of Gene Function on Human Disease provides an integrated view of how genomic and epigenetic processes modulate the impact of dietary factors on health. Written as a resource for researchers, nutrition educators, and policy makers, this book contains the latest scientific findings on the mechanisms of action underlying diet-genome interactions. It presents a unique perspective on the fundamentals of nutritional genomics from genomics, transcriptomics, proteomics, and metabolomics. Contributing authors introduce the important areas of cell signaling and transduction, the intricate regulation of gene expression, and alteration of gene-linked chronic diseases, such as obesity-induced inflammation, insulin resistance, metabolic syndrome, cardiovascular disease, and cancer. The authors detail significant areas of interest within nutritional genomics-including plant-based foods as epigenetic modifiers of gene function and the effects of bioactive phytochemicals on inherited genotype and expressed phenotypes. They also discuss the role of vitamin D in various cancer risks and the gastrointestinal tract as a defense system. Given the key role played by agriculture and the food industry to produce foods to meet personalized health needs, the book also addresses agricultural breeding efforts to enhance nutritional value and the use of technology to increase bioactive ingredients in the food supply. The final chapters discuss manufacturing practices and novel processing techniques for retention of nutrients and bioactive components, as well as the need for regulatory oversight and proper labeling to establish assurance of safety and benefit. An excellent resource for this exciting field, the book identifies future directions for research and opportunities for improving global health and wellness by preventing, delaying, or mitigating chronic diseases with diet.
(source: Nielsen Book Data)9781439844533 20171218
Book
xvi, 426 pages ; 24 cm
  • Nutritional epigenetics and disease prevention: are we there yet? / Mukesh Verma
  • Aging by epigenetics: nutrition, an epigenetic key to long life / Nilanjana Maulik, Gautam Maulik
  • Folate and DNA methylation / Julie Crowell, Anna Ly, Young-In Kim
  • Dietary components, epigenetics, and cancer / Cindy D. Davis, Sharon A. Ross
  • Dietary factors, histone modifications, and cancer prevention / Igor P. Pogribny, Sharon A. Ross, Igor Koturbash
  • Nutrition, epigenetics, and vascular function / M. Carey Satterfield [and others]
  • Role of epigenetic machinery and MicRNAs in diet-induced hepatocarcinogenesis / Kalpana Ghoshal, Tasneem Motiwala
  • Epigenetic mechanisms in lung inflammation and chronic airway diseases and intervention by dietary polyphenols / Irfan Rahman
  • Glycemic memory and epigenetic changes / Andrew L. Siebel, Ana Z. Fernandez, Assam El-Osta
  • Maternal nutrition, intrauterine development, and disease risks in the offspring through epigenetic regulation of gene expression / Yuan-Xiang Pan, Rita Stakovsky, Shasha Zheng
  • Nutritional epigenetics impact on metabolic syndrome / Lakshminarasimhan Pavithra, Sreenivas Chavali, Samit Chattopadhyay
  • Nutrition and the emerging epigenetic paradigm: lessons from neurobehavioral disorders / Axel Schumacher
  • Interactions between folate, other B vitamins, DNA methylation, and neurodevelopmental disorders / Rebecca J. Schmidt, Janine M. LaSalle
  • Dietary factors and the emerging role of epigenetics in neurodegenerative diseases / Lucia Migliore, Fabio Coppedè.
"Extensive research on nutrigenomics has unveiled numerous epigenetic mechanisms that are influenced by our dietary signature. This book illustrates how nutrition can influence epigenetic inheritance and the mechanisms that underlie modification of the metabolic imprint of an individual. The text discusses the basics of nutrigenomics and epigenetic regulation, types of nutrition influencing genetic imprinting, and the role of nutrition in modulating an individual's predisposition to disease. It also covers epigenetic variation, genomic imprinting, maternal nutrition, neonatal nutrition, as well as epigenetics and nutrition relating to cancer, heart disease, and obesity"--Provided by publisher.
Medical Library (Lane)
Book
xv, 426, [4] p. of plates : ill.
  • Preface Acknowledgments The Editors Contributors Nutritional Epigenetics and Disease Prevention: Are We There Yet?, Mukesh Verma Aging by Epigenetics: Nutrition, An Epigenetic Key to Long Life, Nilanjana Maulik and Gautam Maulik Folate and DNA Methylation, Julie Crowell, Anna Ly, and Young-In Kim Dietary Components, Epigenetics, and Cancer, Cindy D. Davis and Sharon A. Ross Dietary Factors, Histone Modifications, and Cancer Prevention, Igor P. Pogribny, Sharon A. Ross, and Igor Koturbash Nutrition, Epigenetics, and Vascular Function, M. Carey Satterfield, Jason R. McKnight, Xilong Li, and Guoyao Wu Role of Epigenetic Machinery and MicRNAs in Diet-Induced Hepatocarcinogenesis, Kalpana Ghoshal and Tasneem Motiwala Epigenetic Mechanisms in Lung Inflammation and Chronic Airway Diseases and Intervention by Dietary Polyphenols , Irfan Rahman Glycemic Memory and Epigenetic Changes, Andrew L. Siebel, Ana Z. Fernandez, and Assam El-Osta Maternal Nutrition, Intrauterine Development, and Disease Risks in the Offspring through Epigenetic Regulation of Gene Expression, Yuan-Xiang Pan, Rita Strakovsky, and Shasha Zheng Nutritional Epigenetics: Impact on Metabolic Syndrome, Lakshminarasimhan Pavithra, Sreenivas Chavali, and Samit Chattopadhyay Nutrition and the Emerging Epigenetic Paradigm: Lessons from Neurobehavioral Disorders, Axel Schumacher Interactions between Folate, Other B Vitamins, DNA Methylation, and Neurodevelopmental Disorders, Rebecca J. Schmidt and Janine M. LaSalle Dietary Factors and the Emerging Role of Epigenetics in Neurodegenerative Diseases, Lucia Migliore and Fabio Coppede Index.
  • (source: Nielsen Book Data)9781439804827 20160605
As nutrition research is shifting its focus from epidemiology and physiology to effects of nutrients at the molecular level, a uniquely tailored diet that corresponds to the demands of our genetic signature is emerging as an indispensable need. Using high-throughput genomic tools, nutrigenomics unravels the influence of micro- and macronutrients as potent dietary signals regulating metabolic pathways and unmasks how susceptible genotypes are predisposed to diet-related diseases. Selected topics from this field have been covered in some books, but no other comprehensive text on epigenetics, nutrition, and human health and disease is available, until now. This book illustrates nutrition's influence on epigenetic inheritance and the mechanisms underlying the modification of the metabolic imprint of an individual. This enriched understanding of nutrigenomics can be applied to master a tailored diet that can alleviate imprinted metabolic syndromes. Specifically, the book focuses on: Maternal, perinatal, and neonatal nutrition Epigenetic mechanisms and cancer Impacts of dietary factors, folate deficiency and DNA methylation Nutrition's influence on genetic imprinting The basics of nutrigenomics and epigenetic regulation.
(source: Nielsen Book Data)9781439804827 20160605
Book
vi, 81 p. : ill. (some col.).
Book
online resource (xx, 180 pages) : illustrations
  • Opportunities and challenges in nutrigenetics/nutrigenomics and health / De Caterina, R.
  • Genome-wide association studies and diet / Ferguson, L.R.
  • Copy number variation, eicosapentaenoic acid and neurological disorders : with particular reference to Huntington's disease and associated CAG repeats and to myalgic encephalomyelitis and viral infection / Puri, B.K.; Manku, M.S.
  • Nutrigenetics : a tool to provide personalized nutritional therapy to the obese / Marti, A.; Goyenechea, E.; Martínez, J.A.
  • Xenobiotic metabolizing genes, meat-related exposures, and risk of advanced colorectal adenoma / Ferrucci, L.M. ... [et al.]
  • Strategies to improve detection of hypertension genes / Hunt, S.C.
  • Diet, nutrition and modulation of genomic expression in fetal origins of adult disease / Jackson, A.A.; Burdge, G.; Lillycrop, K.
  • Choline : clinical nutrigenetic/nutrigenomic approaches for identification of functions and dietary requirements / Zeisel, S.H.
  • Dietary polyphenols, deacetylases and chromatin remodeling in inflammation / Rahman, I., Chung, S.
  • Dietary manipulation of histone structure and function / Ho, E., Dashwood, R.H
  • Changes in human adipose tissue gene expression during diet-induced weight loss / Svensson, P.-A. ... [et al.]
  • Toxicogenomics and studies of genomic effects of dietary components / Thompson, K.
  • Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis / Starlard-Davenport, A. ... [et al.]
  • Redox dysregulation and oxidative stress in schizophrenia : nutrigenetics as a challenge in psychiatric disease prevention / Do, K.Q., Conus, P.; Cuenod, M.
  • Nutrigenomics and agriculture : a perspective / Spence, J.T.
  • Opportunities and challenges in nutrigenetics/nutrigenomics : building industry-academia partnerships / Gillies, P.J. ; Kris-Etherton, P.M.
  • Tailoring foods to match people's genes in New Zealand : opportunities for collaboration / Ferguson, L.R. ... [et al.].
Medical Library (Lane)
Book
1 online resource (100 pages) : illustrations
The key to exploiting links between diet and health is to have a better understanding of how our bodies respond to what we eat. In the past, many food constituents were regarded as unimportant because they lacked a specific nutritional role. More recently nutritional research has been limited to a few dietary compounds, a handful of relevant biochemical pathways and a small number of genes pertinent to specific diseases. These studies have given rise to specific examples of benefits provided by individual/ groups of food compounds including non-nutrients, and demonstrated that whilst poor diet can accelerate age-related degeneration, a diet rich in fruits and vegetables, cereals and plant oils significantly reduces our risk of chronic disease.However, the benefits of dietary and lifestyle choices are not the same for everyone. Nutrigenomics offers a more holistic approach to nutritional research. It considers not only our genes and the effect they have on our response to diet but, also how diet affects our genes and proteins to alter our metabolism and our risk of disease as we age. However, the logistics associated with human study design and interpretation of the data generated, using these technologies, is complex.The European Network of Excellence NuGO was established in 2004 with the specific aim of developing and integrating omic technologies for European nutritional research. This has meant focusing on technical problems specific to nutrition as well as training existing and new researchers to use the technology alongside existing and new approaches. The workshop, Design of human nutrigenomic studies, reviewed examples of successful human nutrition studies using post-genomics technologies (transcriptomics, metabolomics, and proteomics) and the issues discussed are described in detail in this publication.
(source: Nielsen Book Data)9789086860944 20160618
Book
xii, 245 p., [8] p. of plates : ill. (some col.) ; 25 cm.
  • Introduction. DNA, histone, and chromatin structure. DNA methylation. Histone modifications. Chromatin remodeling. Methods for epigenetics research. Nutrients and DNA methylation. Nutrients, histone modification and choramtin remodeling. Nutrients, epigenetics, and embryonic developments. Nutrients, epigenetics, and aging. Nutrients, epigenetics, and cancer. Conclusions and future perspectives.
  • (source: Nielsen Book Data)9781420063547 20160527
Presenting up-to-date research on the relationship between nutrition and the evolving field of epigenetics, this work takes a close look at current findings and the potential impact of this research on our understanding of aging, embryonic growth, and the development of cancer. With the aid of numerous color illustrations and photographs, it effectively describes how nutrients modulate physiologic and pathologic processes. Providing a starting point for further research, as well as applicable clinical information, it covers a range of cutting-edge topics that include current findings on DNA methylation, histone modification, and chromatin remodeling. It also details methods to measure epigenetic phenomena.
(source: Nielsen Book Data)9781420063547 20160527
SAL3 (off-campus storage)
Book
1 online resource (xii, 399 pages) : illustrations.
  • Section I. Introduction
  • Nutrigenomics and proteomics in health and disease: an overview / Yoshinori Mine, Kazuo Miyashita, and Fereidoon Shahidi
  • Omics in nutrition and health research / Michael Affolter, Frďřic Raymond, and Martin Kussman
  • Section II. Genomics and proteomics in health and diseases
  • Toward personalized nutrition and medicine: promises and challenges / Baitang Ning and Jim Kaput
  • Obesity and nuclear receptors: effective genomic strategies in functional foods / Teruo Kawada [and others]
  • Inflammatory genes involved in obesity-induced inflammatory responses and pathologies / Rina Yu
  • Genomics and proteomics in allergy / Icy D'Silva and Yoshinori Mine
  • g Section III. Food factors
  • gene interactions
  • Beneficial effects of conjugated linoleic acid / Kazunori Koba and Teruyoshi Yanagita
  • Regulation of gene transcription by fatty acids / Jean-Paul Pǧorier
  • Nonnutrient functionality of amino acids / Yoshinori Mine and Connie J. Kim
  • Functional bioactive proteins and peptides in nutrigenomics / Denise Young and Yoshinori Mine
  • Antiobesity effect of allenic carotenoid, fucoxanthin / Kazuo Miyashita and Masashi Hosokawa
  • Control of systemic inflammation and chronic diseases
  • The use of turmeric and curcuminoids / Stig Bengmark
  • Alteration in gene expression and proteomic profiles by soy isoflavone / Fazlul H. Sarkar and Yiwei Li
  • Green tea polyphenol-modulated genome functions for protective health benefits / Molay K. Roy, Mahendra P. Kapoor, and Lekh R. Juneja
  • Oat avenanthramides: a novel antioxident / Li Li Ji, Ryan Koenig, and Mitchell L. Wise
  • Cancer-preventive effects and molecular actions of anthocyanins / De-Xing Hou
  • Food components activating Capsaicin receptor TRPV1 / Tatsuo Watanabe [and others]
  • New therapeutic effects of anthocyanins: antiobesity effect, antidiabetes effect, and vision improvement / Takanori Tsuda and Hitoshi Matsumoto
  • Licorice flavonoids / Shinichi Honda, Yuji Tominaga, and Shinichi Yokota
  • Isoprenols / Tsuyoshi Goto [and others]
  • Anti-inflammatory and anticarcinogenesis potentials of citrus coumarins and polymethylated flavonoids / Akira Murakami and Hajime Ohigashi
  • Probiotics: food for thought / Kingsley C. Anukam and Gregor Reid
  • Section IV. Advanced analytical techniques for nutrigenomics and proteomics
  • Microarrays: a powerful tool for studying the functions of food and its nutrients / Hiroshi Mano, Jun Shimizu, and Masahiro Wada
  • Challenges and current solutions in proteomic sample preparations / Feng Tao
  • Computational methods in cancer gene networking / Edwin Wang
  • Peptidomics / Yoshinori Mine.
Part of the Functional Food Science and Technology book series (Series Editor: Fereidoon Shahidi), this book compiles the current science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals (food factors) and their impact on gene interaction and health. Authored by a stellar international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date.
(source: Nielsen Book Data)9780813800332 20171211
Book
xvi, 293 p. : ill. ; 23 cm.
  • Nutrigenomics: Current Research Trends
  • Translating Nutrigenomics Research into Practice: The Example of Soy Protein
  • Application of Nutrigenomics: An Industry Perspective
  • Regulation of Genetic Tests: An International Comparison
  • Risk-Based Regulation of Direct-to-Consumer Nutrigenetic Tests
  • The Impact of Genomics on Innovation in Foods and Drugs: Can Canadian Law Step Up to the Challenge?
  • Placing healthy eating in the everyday context: towards an action approach of gene-based personalized nutrition advice
  • Health Care Provider Capacity in Nutrition and Genetics-A Canadian Case Study
  • Advancing Knowledge Translation in Nutritional Genomics by Addressing Knowledge, Skills and Confidence Gaps of Registered Dietitians
  • Understanding Hopes and Concerns about Nutrigenomics: Canadian public opinion research involving health care professionals and the public
  • Pitching products, pitching ethics: Selling nutrigenetic tests as lifestyle or medicine
  • Framing Nutrigenomics for Individual and Public Health: Public Representations of an Emerging Field
  • The Personal and the Public in Nutrigenomics
  • Food Styles and the Future of Nutrigenomics.
Nutrigenomics is the rapidly developing field of science that studies nutrient-gene interaction. This field has broad implications for understanding the interaction of human genomics and nutrition, but can also have very specific implications for individual dietary recommendations in light of personal genetics. Predicted applications for nutrigenomics include genomics-based dietary guidelines and personalized nutrition based on individual genetic tests. These developments have sweeping ethical, legal and regulatory implications for individuals, corporations and governments. This book brings together experts in ethics, law, regulatory analysis, and communication studies to identify and address relevant issues in the emerging field of nutritional genomics. Contributing authors are experts in the social aspects of biotechnology innovation, with expertise in nutrigenomics.From addressing the concern that nutrigenomics will transform food into medicine and undermine pleasures associated with eating to the latest in the science of nutrigenomics, this book provides a world-wide perspective on the potential impact of nutrigenomics on our association with food. This book explores the rapidly developing, yet not fully understood, impact of nutrigenomics on the relationship to food medicalization, genetic privacy, nutrition and health. It provides ground for further exploration to identify issues and provide analysis to aid in policy and regulation development. It also provides ethical and legal insights into this unfolding science, as well as serving as a model for thinking about issues arising in other fields of science and technology.
(source: Nielsen Book Data)9780123741257 20160528
Book
computer files (xx, 261 pages : illustrations (some color), map ; 24 cm)
Medical Library (Lane)

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