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• This unique volume presents a fruitful and beautiful mathematical world hidden in Caianiello's neuronic equations, which describe the instantaneous behavior of a model of a brain or thinking machine. The detailed analysis from a viewpoint of "dynamical systems", even in a single neuron case, enables us to obtain amazingly good rational approximations to the Hecke-Mahler series with two variables. Some interesting numerical applications of our rational approximations are also discussed.This book is fundamentally self-contained and many topics required in it are explained from the beginning. Each chapter contains a number of instructive and mostly original exercises at various levels.
• (source: Nielsen Book Data)

This unique volume presents a fruitful and beautiful mathematical world hidden in Caianiello's neuronic equations, which describe the instantaneous behavior of a model of a brain or thinking machine. The detailed analysis from a viewpoint of "dynamical systems", even in a single neuron case, enables us to obtain amazingly good rational approximations to the Hecke-Mahler series with two variables. Some interesting numerical applications of our rational approximations are also discussed.This book is fundamentally self-contained and many topics required in it are explained from the beginning. Each chapter contains a number of instructive and mostly original exercises at various levels.
(source: Nielsen Book Data)

• This unique volume presents a fruitful and beautiful mathematical world hidden in Caianiello's neuronic equations, which describe the instantaneous behavior of a model of a brain or thinking machine. The detailed analysis from a viewpoint of "dynamical systems", even in a single neuron case, enables us to obtain amazingly good rational approximations to the Hecke-Mahler series with two variables. Some interesting numerical applications of our rational approximations are also discussed.This book is fundamentally self-contained and many topics required in it are explained from the beginning. Each chapter contains a number of instructive and mostly original exercises at various levels.
• (source: Nielsen Book Data)

This unique volume presents a fruitful and beautiful mathematical world hidden in Caianiello's neuronic equations, which describe the instantaneous behavior of a model of a brain or thinking machine. The detailed analysis from a viewpoint of "dynamical systems", even in a single neuron case, enables us to obtain amazingly good rational approximations to the Hecke-Mahler series with two variables. Some interesting numerical applications of our rational approximations are also discussed.This book is fundamentally self-contained and many topics required in it are explained from the beginning. Each chapter contains a number of instructive and mostly original exercises at various levels.
(source: Nielsen Book Data)

• Comparing the Properties of Neuronal Culture Systems Growing and Working with Peripheral Neurons Dissection and Culturing of Chick Ciliary Ganglion Neurons The Culture of Chick Forebrain Neurons Growing and Working with Spinal Motor Neurons Avian Purkinje Neuronal Cultures Culturing Hippocampal and Cortical Neurons Working with Xenopus Spinal Neurons in Live Cell Cultures Culturing Neurons from the Snail Helisoma The Ti1 Pioneer Pathway Techniques to Dissect Cellular and Subcellular Function in Drosphila Nervous System PC12 Cells as a Model for Studies of Regulated Secretion in Neuronal and Endocrine Cells and more.
• (source: Nielsen Book Data)

This book lays out numerous simple techniques for growing and carrying out experiments with many varieties of neurons. Subjects include peripheral and central neurons from vertebrate and invertebrate sources, as well as neuron-like cell lines. It also explains recent advances in our ability to introduce exogenous proteins and genes to neurons in culture. Procedures for successful protein infiltration, biolistic transfection, electroporation, and viral transgenic methods in neurons are also presented. It contains culture methodology for more than a dozen types of CNS and PNS neurons. It includes most recent and reliable techniques from expert practitioners for specific experimental applications. It addresses the latest strategies for transfecting neurons.
(source: Nielsen Book Data)
Written by cell biologists and neuroscientists, this volume in the "Methods in Cell Biology" series is a detailed guide for cell biologists who would like to approach their experimental questions using nature's most interesting cells - neurons. Many cell biologists study the properties of cells grown outside of the animal in the controlled environment of a culture dish, but they would benefit from directing their attention to nerve cells as they are well-suited to almost every area of cell biological inquiry. This book lays out numerous simple techniques for growing and carrying out experiments with many varieties of neurons. Subjects include peripheral and central neurons from vertebrate and invertebrate sources, as well as neuron-like cell lines. It also explains recent advances in our ability to introduce exogenous proteins and genes into neurons in culture. Procedures for successful protein infiltration, biolistic transfection, electroporation, and viral transgenic methods in neurons are also presented. With the current and reliable information contained in this volume, growing various kinds of neurons in culture and using them for diverse experimental applications will be easy for cell biologists to master! It contains culture methodology for more than a dozen types of CNS and PNS neurons. It includes most recent and reliable techniques from expert practitioners for specific experimental applications. It addresses the latest strategies for transfecting neurons.
(source: Nielsen Book Data)

• Preface-- Acknowledgments--
• 1. Background--
• 2. The noradrenergic neuron--
• 3. Noradrenaline release--
• 4. Adrenoceptors--
• 5. Noradrenaline synthesis and metabolism--
• 6. Regulation of receptors--
• 7. Regulation of synthesis--
• 8. Regulation of release--
• 9. Plasticity of noradrenaline neurons--
• 10. Peripheral noradrenergic neurons--
• 11. Central noradrenergic neurons--
• 12. Function of the locus ceruleus--
• 13. Conclusion-- Index.
• (source: Nielsen Book Data)

Noradrenergic Neurons examines the mechanisms that regulate the release and synthesis of the neurotransmitter noradrenaline. Noradrenaline (or norepinephrine) and the physiological activity of the cells that manufacture and release it, play an important role in response to stress and the development of resistance to stress, as well as psychological mood itself. This book discusses the response of the various noradrenergic receptor subtypes to noradrenaline, and the long-lasting changes that underlie the striking plasticity of function manifested by noradrenergic cells, which in turn are reflected in observable behavioural plasticity. In recent years there has been no single book that presents an up-to-date synthesis of current knowledge on the biochemical anatomical and physiological aspects of this important group of brain and peripheral nervous system cells and their function in the whole behaving organism and this book aims to fill that gap.
(source: Nielsen Book Data)

• Microscopes, image acquisition and the basics of fluorescence imaging-- confocal microscopy-- multiphoton microscopy-- photoactivation-- calcium imaging-- imaging other aspects of neuronal function-- genetically engineered fluorescent probes.
• (source: Nielsen Book Data)

This manual provides a comprehensive description of the range of imaging technologies being applied to living cells. It is based on a course taught at Cold Spring Harbour Laboratory by the editors and contributors, and covers cutting-edge techniques such as multiphoton excitation microscopy.
(source: Nielsen Book Data)

• Part 1 Neurons as cells: studying the neuron using intracellular recording - the action potential and neuronal anatomy-- an introduction to neurochemistry - acetylcholinesterase assay-- immnunocytochemical localization of neuronal transmitters - two methods for identifying neurotransmitters in situ-- pharmacological manipulation of catecholamine neurochemical levels - an analysis using HPLC-- Ca-activated chloride conductance in Xenopus Oocytes - introduction to methods of molecular neurobiology.
• Part 2 Neurons forming connections: synaptic transmission and synaptic plasticity - the neuromuscular junction of the crayfish-- tracing neural connections - thalamo-corticol interconnections in the mammalian somatosensory system-- information coding and receptive fields - properties of mammalian neurons recorded in rat thalamus-- field potential recording in the hippocampal slice-- long-term potential - stimulating and recording in the hippocampus of an anaesthetized rat.
• Part 3 Neurons co-ordinating behaviour: observational methods used to assess behaviour-- neuropharmacology - comparison of behavioural response in infant and adult rats after drug administration-- chronic recording from rat brain - hippocampal theta rhythm-- effects of lesion on spatial and non-spatial learning-- control of the ovulatory cycle and sexual behaviour in the Syrian hamster.
• Part 4 Techniques: using electrophysiological equipment-- surgery procedures-- perfusion and sectioning-- staining - Golgi, Nissl, acethycholinesterase and choline acetyltransferase. Appendices: sources of equipment-- addresses of suppliers-- use of animals in experiments.
• (source: Nielsen Book Data)

This is a collection of investigative laboratory experiments designed for the advanced undergraduate and the first- or second-year graduate student. In the first of its three major sections, neurons are studied as individual cells, including topics such as intracellular recording, immunocytochemistry, and HPLC. The second section studies neurons as forming connections, with experiments on tract tracing, information coding, and LTP, and the third section looks at neurons as co-ordinators of behaviour, through approaches such as pharmacology, lesioning, and ethology. The fourth and final section focuses on techniques applicable to several experiments in the collection, including electrophysiological recording, surgery, anaesthetics, and staining methods. The experiments are designed to introduce students to the techniques used in neuroscience research laboratories. They have been tested and should be easily integrated into existing neuroscience courses of any length or emphasis.
(source: Nielsen Book Data)

• E. Perl: Function of dorsal root ganglion neurons: an overview--
• Section I: Phenotypic diversity among sensory neurons: S.N. Lawson: Morphological and biochemical cell types of sensory neurons-- S.P. Hunt, P.W. Mantyh & J.V. Priestley: The organization of biochemically characterized sensory neurons-- H.R. Koerber & L.M. Mendell: Functional heterogeneity of dorsal root ganglion cells-- M.C. Nowycky: Voltage-gated ion channels in dorsal root ganglion neurons-- P.B. Brown & H.R. Koerber: Somatotopic organization of primary afferent projections to the spinal cord-- R. Fyffe: Laminar organization of primary afferent termination in the mammalian spinal cord--
• Section II: Development of sensory neurons: N.N.M. LeDouarin, M.A. Teillet & C. Kalcheim: The cellular and molecular basis of early sensory ganglion development-- K.S. Vogel: Origins and early development of vertebrate cranial sensory neurons-- A.M. Davies: Cell death and the trophic requirements of developing sensory neurons-- L.F. Reichardt: Adhesive interactions that regulate neuronal behavior-- S.A. Scott: The development of peripheral sensory innervation patterns-- M. O'Donovan & M. Lee: The development of muscle afferent connections in the vertebrate spinal cord-- M. Fitzgerald & B. Fulton: The physiological properties of developing sensory neurons--
• Section III: Regeneration and plasticity in mature sensory neurons: J. Diamond & A. Gloster: Regulation of the sensory innervation of skin: trophic control of collateral sprouting-- S.B. McMahon: Plasticity of central terminations of primary sensory neurons in the adult animal-- G. Grant, H. Aldskogius & J. Arvidsson: Axotomy-induced changes in primary sensory neurons-- R.D. Johnson & J.B. Munson: Specificity of regenerating sensory neurons in adult mammals-- R.M. Lindsay-- The role of neurotrophic factors in functional maintenance of mature sensory neurons.
• (source: Nielsen Book Data)

Vertebrate sensory neurons occupy a unique place in the nervous system, conveying information from the periphery to the central nervous system. While sensory physiologists have long recognized differences in response properties among cells in dorsal root and cranial ganglia, the full extent of heterogeneity among these neurons has only recently become apparent. Phenotypic diversity is the underlying theme of this unique work, which summarizes our current understanding of the individual characteristics and development of sensory neurons. The chapters are arranged in three cohesive sections. The first describes heterogeneity in the function, biochemical make-up, ion channels, membrane properties, and central projection patterns of dorsal root ganglion neurons. The second section discusses the development of sensory neurons, covering such topics as the origins of dorsal root and cranial ganglia, adhesive interactions involved in axon outgrowth, trophic dependence of sensory neurons, and the development of the physiological properties and central and peripheral connections of dorsal root ganglion neurons. The last section explains regeneration and plasticity of mature neurons, including sprouting of skin sensory axons, plasticity in central terminations, axotomy and regeneration, and the continuing role of neurotrophic factors in adult neurons.
(source: Nielsen Book Data)

With this Handbook Series, IBRO aims to fill a major gap in the world literature. The neuroscientist needs to be able to turn to whichever specialised method is most suited to the problem he is currently studying. Methods in the Neurosciences will help to provide expert advice on exactly how to carry out the experiments, on what difficulties can occur and on the limitations of the method. Monoaminergic Neurons: Light Microscopy and Ultrastructure is the tenth book in the series; it provides detailed technical information on the procedures for studying neurons containing amines (noradrenaline, dopamine, 5-hydroxytryptamine and histamine) in the peripheral and central nervous system, using light or electron microscopy. These (immuno)histochemical techniques are invaluable for demonstrating the distribution and anatomical complexity of nerve fibres and for the analysis of the synaptic connections of this important class of neurons. Three light microscope techniques are described in detail: formaldehyde-induced fluorescence; immunohistochemistry using antibodies to the synthesising enzymes; immunofluorescence and immunohistochemistry using antibodies to the monoamines themselves. The use of autoradiography and Golgi-electron microscopy is described, as well as the fine-structural localisation of the enzymes and some of the monoamines. The book provides an ideal introduction to this methodology for all basic neuroscientists, neuroanatomists, neuropharmacologists and neuropathologists.
(source: Nielsen Book Data)

• Introduction to nonlinear oscillators / I. Stewart
• Identical oscillator networks with symmetry / P.B. Ashwin
• Bifurcating neurones / A.V. Holden ... [et al.]
• A model for low threshold oscillations in neurons / J.L. Hindmarsh, R.M. Rose
• Information processing by oscillating neurons / C.L.T. Mannion, J.G. Taylor
• Gamma oscillations, association and consciousness / R.M.J. Cotterill, C. Nielsen
• Modelling of cardiac rhythm : from single cells to massive networks / D. Noble ... [et al.].

This volume contains the proceedings of a day conference on coupled neuronal oscillators (CNO '90, London), an important aspect of neural network research, which may hold the key to a clearer appreciation of the manner in which neural networks can control complex behaviour. The contributors to the conference looked at the physiological properties of neurons in terms of electrochemical features, using these to consider possible directions for future research. The papers cover a range of areas, including an introduction to non-linear oscillators, bifurcating neurons, the modelling of cardiac rhythm, gamma oscillations, association and consciousness, and a model for low threshold oscillations in neurons. The papers also include new explanations and models of the phenomena of coupled oscillatory neural assemblies, ranging from those for the multi-phasic response of single neurons, to possible models of image segmentation.
(source: Nielsen Book Data)

A framework for modeling and simulating biological neural systems

When first published, "Neurons and Networks" filled the need for an introductory neuroscience text that is accessible, authoritative, logically organized, and concise. Avoiding the encyclopedic coverage that makes most neuroscience texts overwhelming, "Neurons and Networks" focused instead on building the solid foundation of understanding and knowledge required for further study. This edition retains the features that made the first edition so attractive: consistent emphasis on results and concepts that have stood the test of time; abundant high-quality illustrations; exceptionally clear explanations of technical terms. Completely revised and enlarged with six new chapters, the second edition is an introduction not just to neurobiology, but to all of behavioral neuroscience.
(source: Nielsen Book Data)

• Part 1 Neurons - cellular neuroscience: probing the brain - anatomical approaches - visualizing neurons, physiological approaches - recording electrical activity, molecular biological approaches - mapping molecules-- cells and synapses - neurons and glia, neuronal structure, synapses-- membranes and the resting potential - properties of neural potentials, membranes - their structure and electrical properties, resting potentials-- action potentials and their propagation - the generation of action potentials, the propagation of action potentials-- synaptic potentials - excitatory and inhibitory synapses, the Axon Hillock and the generation of action potentials, analyzing synaptic potentials, the neuromuscular junction-- the chemistry of synaptic transmission - mechanisms of synaptic transmission, myasthenia gravis - a neuromuscular disease, neurotransmitters and neuromodulators-- receptor potentials - mechanoreceptors, invertebrate photoreceptors, vertebrate photoreceptors-- membrane channels and receptor proteins - the acetylcholine-gated channel-- "Shaker" flies and potassium channels, visual pigments and receptor proteins.
• Part 2 Networks - integrative neuroscience: invertebrate nervous systems - nervous system design, mechanisms underlying behaviour-- control of rhythmic motor behaviour - the heartbeat in the leech, swimming in "Tritonia", modulation of neural circuits-- an invertabrate model of memory and learning - early theories, the Gill-withdrawal reflex in "Aplysia"-- the neural circuitry of the reflex, long-term habituation and sensitization, a summary scheme of habituation and sensitization-- the vertebrate brain - the central nervous system, the spinal cord, the brain-- motor control in vertebrates - the autonomic nervous system, voluntary movement-- retinal processing of visual information - the retina, the initial stages of visual processing, cellular mechanisms, functional organization of the retina, modulation of retinal synapses-- cortical processing of visual information - the lateral geniculate nucleus, the visual cortex, binocular interaction and depth perception-- the architecture of the visual cortex - lateral geniculate architecture, the visual cortex - area V1, cortical plasticity - the effects of visual deprivation, mechanisms underlying deprivation changes-- the development of the brain - the neural plate, tube, and crest, the differentiation of enurons, axon projection and and synapse formation, axonal guidance-- toward an understanding of higher brain function - higher cortical processing, studying the human brain. Appendix: electrical charge and circuits.
• (source: Nielsen Book Data)

How the brain perceives our environment and controls our actions is a subject that we have only begun to understand during the 20th century. The pace of brain research has accelerated dramatically and neuroscience is now one of the most active branches of all the natural sciences. This illustrated book presents an introduction for beginning students and others that joins two major approaches to the field. First, since the brain - like any other organ - is made up of cells, Dowling covers the essentials of cellular and molecular neurobiology, introducing the specialized structure and function of individual nerve cells. In the second half of the book he presents an overview of integrative neuroscience, which describes the processing of information by aggregates of nerve cells, for it is from these networks of the nervous system that behaviour emerges. "Neurons and Networks" does not aim to be encyclopaedic; instead, it offers in-depth coverage of carefully selected topics. Tangential matters and technical jargon are avoided. The author draws examples from invertebrate and vertebrate nervous systems, reflecting the variety of organisms that have been studied over the years, and especially from the visual system, which is perhaps better understood than any other system of the brain. Throughout, basic biological principles are kept in the forefront to ensure that readers grasp the mechanisms underlying neuronal functions. John Dowling draws on more than 20 years of research and undergraduate teaching to create a book that aims to meet the needs of a wide range of students. He incorporates over 250 illustrations based on actual recordings and experiments to ground the biological concepts in the real world of the laboratory. To convey the vitality of the science, Dowling describes the experimental observations leading to important discoveries, then explains or speculates on the significance of the findings. This introduction to a dynamic field should attract curious general readers as well as beginning students of brain function, including computer scientists, psychologists, molecular biologists and budding neuroscientists.
(source: Nielsen Book Data)