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Book
1 online resource Digital: text file; PDF.
  • Introduction to Capillary Electrophoresis-Mass Spectrometry.- Coated Capillaries for CE-MS of Therapeutic Protein.- Intact Mass Analysis of Monoclonal Antibodies by Capillary Electrophoresis-Mass Spectrometry.- Separation and Characterization of Proteins and Peptides in Biological Fluids using CE-MS.- Host Cell Protein Analysis using CE-MS.- Antibody PTM Analysis using CE-MS.- Characterization of Intact Therapeutic Proteins and Protein Subunits using CE-MS Platform.
  • (source: Nielsen Book Data)9783319462387 20170117
This book covers the latest developments in capillary electrophoresis-mass spectrometry for the analysis of therapeutic proteins. The application of capillary electrophoresis-mass spectrometry (CE-MS) coupling technology in the analysis of recombinant therapeutic proteins is detailed thoroughly. Specific topics include recent developments in coupling capillary electrophoresis with mass spectrometry for the quality control of monoclonal antibody therapeutics, top-down analysis of monoclonal antibody using the CE-MS platform, and detection of host cell protein impurities. Comprehensive characterization of antibody-drug conjugates (ADCs) by coupling capillary electrophoresis with mass spectrometry is also covered. This is an ideal book for scientists in the life science and biopharmaceutical industry who are working on characterizing the PTMs of monoclonal antibodies, as well as graduate students and researchers in the separation science and biological mass spectrometry fields.
(source: Nielsen Book Data)9783319462387 20170117
Book
online resource (xv, 333 pages) : illustrations (some color)
  • Mass spectrometry in clinical laboratory : applications in biomolecular analysis / Uttam Garg and Yan Victoria Zhang
  • Quantification of free carnitine and acylcarnitines in plasma or serum using HPLC/MS/MS / David Scott, Bryce Heese, and Uttam Garg
  • Quantification of arginine and its methylated derivatives in plasma by high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS) / Faye B. Vicente ... [et al.]
  • Quantitation of albumin in urine by liquid chromatography tandem mass spectrometry / Hemamalini Ketha and Ravinder J. Singh
  • Quantitation of aldosterone in serum or plasma using liquid chromatography-tandem mass spectrometry (LC- MS/MS) / J. Grace Van Der Gugten and Daniel T. Holmes
  • Quantification of five clinically important amino acids by HPLC-Triple TOF 5600 based on pre-column double derivatization method / Shuang Deng, David Scott, and Uttam Garg
  • Sensitive, simple, and robust nano-liquid chromatography-mass spectrometry method for amyloid protein subtyping / Drew Payto, Courtney Heideloff, and Sihe Wang
  • Quantitation of ubiquinone (coenzyme Q10) in serum/plasma using liquid chromatography electrospray tandem mass spectrometry (ESI-LC-MS/MS) / Richard E. Mathieu Jr. and Catherine P. Riley
  • Quantitative analysis of salivary cortisol using LC-MS/MS / Yan Victoria Zhang
  • Quantification of dihydroxyacetone phosphate (DHAP) in human red blood cells by HPLC-TripleTOF 5600 mass spectrometer / Shuang Deng ... [et al.]
  • Simultaneous quantitation of estradiol and sstrone in serum using liquid chromatography mass spectrometry / Catherine P. Riley, Richard E. Mathieu Jr., and Carmen Wiley
  • Direct measurement of free estradiol in human serum and plasma by equilibrium dialysis-liquid chromatography-tandem mass spectrometry / Julie A. Ray ... [et al.]
  • Quantification of γ-aminobutyric acid in cerebrospinal fluid using liquid chromatography-electrospray tandem mass spectrometry / Erland Arning and Teodoro Bottiglieri
  • Quantitation of insulin analogues in serum using immunoaffinity extraction, liquid chromatography, and tandem mass spectrometry / J. Grace Van Der Gugten, Sophia Wong, and Daniel T. Holmes
  • Quantitation of insulin-like growth factor 1 in serum by liquid chromatography high resolution accurate-mass mass spectrometry / Hemamalini Ketha and Ravinder J. Singh
  • Quantitation of free metanephrines in plasma by liquid chromatography-tandem mass spectrometry / Courtney Heideloff, Drew Payto, and Sihe Wang
  • Quantification of metanephrine and normetanephrine in urine using liquid chromatography-tandem mass spectrometry / Jessica Gabler and Sihe Wang
  • High-throughput analysis of methylmalonic acid in serum, plasma, and urine by LC-MS/MS. Method for analyzing isomers without chromatographic separation / Mark M. Kushnir ... [et al.]
  • Quantitation of 5-methyltetrahydrofolate in cerebrospinal fluid using liquid chromatography-electrospray tandem mass spectrometry / Erland Arning and Teodoro Bottiglieri
  • Quantitative organic acids in urine by two dimensional gas chromatography-time of flight mass spectrometry (GCxGC-TOFMS) / Lawrence Sweetman, Paula Ashcraft, and Jeanna Bennett-Firmin
  • High sensitivity measurement of pancreatic polypeptide and its variant in serum and plasma by LC-MS/MS / Hernando Escobar ... [et al.]
  • Quantitation of parathyroid hormone in serum or plasma by liquid chromatography-tandem mass spectrometry / Hemamalini Ketha and Ravinder J. Singh
  • Determination of phenylalanine and tyrosine by high performance liquid chromatography-tandem mass spectrometry / Judy Peat and Uttam Garg
  • Urine purine metabolite determination by UPLC-tandem mass spectrometry / Qin Sun
  • Urine pyrimidine metabolite determination by HPLC tandem mass spectrometry / Qin Sun
  • Quantitation of plasma renin activity in plasma using liquid chromatography-tandem mass spectrometry (LC- MS/MS) / J. Grace Van Der Gugten and Daniel T. Holmes
  • Quantitation of S-adenosylmethionine and S-adenosylhomocysteine in plasma using liquid chromatography electrospray tandem mass spectrometry / Erland Arning and Teodoro Bottiglieri
  • Simple, high-throughput method for analysis of ceramide, glucosylceramide, and ceramide trihexoside in dried blood spots by LC/MS/MS / Wei-Lien Chuang, Joshua Pacheco, and Kate Zhang
  • Quantification of dehydroepiandrosterone, 11-Deoxycortisol, 17-Hydroxyprogesterone, and testosterone by liquid chromatography-tandem mass spectrometry (LC/MS/MS) / Ada Munar, Clint Frazee, and Uttam Garg
  • Urinary succinylacetone analysis by gas chromatography-mass spectrometry (GC-MS) / Hongjie Chen and Chunli Yu
  • Quantification of 1,25-Dihydroxyvitamin D2 and D3 in serum using liquid chromatography-tandem mass spectrometry / Jonathon Mahlow, Dustin R. Bunch, and Sihe Wang
  • High-throughput serum 25-hydroxy vitamin D testing with automated sample preparation / Judy Stone
  • Quantitation of 25-OH-Vitamin-D2 and 25-OH-Vitamin-D3 in urine using LC-MS/MS / Dean C. Carlow, Ryan C. Schofield, and Michelle Denburg.
Medical Library (Lane)
Book
xv, 333 pages : illustrations (some color) ; 26 cm.
  • Mass spectrometry in clinical laboratory : applications in biomolecular analysis / Uttam Garg and Yan Victoria Zhang
  • Quantification of free carnitine and acylcarnitines in plasma or serum using HPLC/MS/MS / David Scott, Bryce Heese, and Uttam Garg
  • Quantification of arginine and its methylated derivatives in plasma by high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS) / Faye B. Vicente [and others]
  • Quantitation of albumin in urine by liquid chromatography tandem mass spectrometry / Hemamalini Ketha and Ravinder J. Singh
  • Quantitation of aldosterone in serum or plasma using liquid chromatography-tandem mass spectrometry (LC- MS/MS) / J. Grace Van Der Gugten and Daniel T. Holmes
  • Quantification of five clinically important amino acids by HPLC-Triple TOF 5600 based on pre-column double derivatization method / Shuang Deng, David Scott, and Uttam Garg
  • Sensitive, simple, and robust nano-liquid chromatography-mass spectrometry method for amyloid protein subtyping / Drew Payto, Courtney Heideloff, and Sihe Wang
  • Quantitation of ubiquinone (coenzyme Q10) in serum/plasma using liquid chromatography electrospray tandem mass spectrometry (ESI-LC-MS/MS) / Richard E. Mathieu Jr. and Catherine P. Riley
  • Quantitative analysis of salivary cortisol using LC-MS/MS / Yan Victoria Zhang
  • Quantification of dihydroxyacetone phosphate (DHAP) in human red blood cells by HPLC-TripleTOF 5600 mass spectrometer / Shuang Deng [and others]
  • Simultaneous quantitation of estradiol and sstrone in serum using liquid chromatography mass spectrometry / Catherine P. Riley, Richard E. Mathieu Jr., and Carmen Wiley
  • Direct measurement of free estradiol in human serum and plasma by equilibrium dialysis-liquid chromatography-tandem mass spectrometry / Julie A. Ray [and others]
  • Quantification of γ-aminobutyric acid in cerebrospinal fluid using liquid chromatography-electrospray tandem mass spectrometry / Erland Arning and Teodoro Bottiglieri
  • Quantitation of insulin analogues in serum using immunoaffinity extraction, liquid chromatography, and tandem mass spectrometry / J. Grace Van Der Gugten, Sophia Wong, and Daniel T. Holmes
  • Quantitation of insulin-like growth factor 1 in serum by liquid chromatography high resolution accurate-mass mass spectrometry / Hemamalini Ketha and Ravinder J. Singh
  • Quantitation of free metanephrines in plasma by liquid chromatography-tandem mass spectrometry / Courtney Heideloff, Drew Payto, and Sihe Wang
  • Quantification of metanephrine and normetanephrine in urine using liquid chromatography-tandem mass spectrometry / Jessica Gabler and Sihe Wang
  • High-throughput analysis of methylmalonic acid in serum, plasma, and urine by LC-MS/MS. Method for analyzing isomers without chromatographic separation / Mark M. Kushnir [and others]
  • Quantitation of 5-methyltetrahydrofolate in cerebrospinal fluid using liquid chromatography-electrospray tandem mass spectrometry / Erland Arning and Teodoro Bottiglieri
  • Quantitative organic acids in urine by two dimensional gas chromatography-time of flight mass spectrometry (GCxGC-TOFMS) / Lawrence Sweetman, Paula Ashcraft, and Jeanna Bennett-Firmin
  • High sensitivity measurement of pancreatic polypeptide and its variant in serum and plasma by LC-MS/MS / Hernando Escobar [and others]
  • Quantitation of parathyroid hormone in serum or plasma by liquid chromatography-tandem mass spectrometry / Hemamalini Ketha and Ravinder J. Singh
  • Determination of phenylalanine and tyrosine by high performance liquid chromatography-tandem mass spectrometry / Judy Peat and Uttam Garg
  • Urine purine metabolite determination by UPLC-tandem mass spectrometry / Qin Sun
  • Urine pyrimidine metabolite determination by HPLC tandem mass spectrometry / Qin Sun
  • Quantitation of plasma renin activity in plasma using liquid chromatography-tandem mass spectrometry (LC- MS/MS) / J. Grace Van Der Gugten and Daniel T. Holmes
  • Quantitation of S-adenosylmethionine and S-adenosylhomocysteine in plasma using liquid chromatography electrospray tandem mass spectrometry / Erland Arning and Teodoro Bottiglieri
  • Simple, high-throughput method for analysis of ceramide, glucosylceramide, and ceramide trihexoside in dried blood spots by LC/MS/MS / Wei-Lien Chuang, Joshua Pacheco, and Kate Zhang
  • Quantification of dehydroepiandrosterone, 11-Deoxycortisol, 17-Hydroxyprogesterone, and testosterone by liquid chromatography-tandem mass spectrometry (LC/MS/MS) / Ada Munar, Clint Frazee, and Uttam Garg
  • Urinary succinylacetone analysis by gas chromatography-mass spectrometry (GC-MS) / Hongjie Chen and Chunli Yu
  • Quantification of 1,25-Dihydroxyvitamin D2 and D3 in serum using liquid chromatography-tandem mass spectrometry / Jonathon Mahlow, Dustin R. Bunch, and Sihe Wang
  • High-throughput serum 25-hydroxy vitamin D testing with automated sample preparation / Judy Stone
  • Quantitation of 25-OH-Vitamin-D2 and 25-OH-Vitamin-D3 in urine using LC-MS/MS / Dean C. Carlow, Ryan C. Schofield, and Michelle Denburg.
This volume provides stepwise instructions for the analysis of numerous clinically important analytes by mass spectrometry. Mass spectrometry offers clinical laboratory scientists a number of advantages including increased sensitivity and specificity, multiple component analysis, and no need for specialized reagents. The techniques described are a must for the measurement of many clinically relevant analytes in the fields of drug analysis, endocrinology, and inborn errors of metabolism. Each chapter provides a brief introduction about a specified analyte, followed by detailed instructions on the analytical protocol. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and practical, Clinical Applications of Mass Spectrometry in Biomolecular Analysis: Methods and Protocols is a great resource for clinical laboratory scientists who are already using or thinking of bringing mass spectrometry to their laboratories.
(source: Nielsen Book Data)9781493931811 20160619
Science Library (Li and Ma)
Book
ix, 533 pages : illustrations (some color) ; 26 cm
  • Sample preparation strategies for proteomics. Proteomes, their compositions and their sources / Anna Kwasnik, Claire Tonry, Angela Mc Ardle, Aisha Qasim Butt, Rosanna Inzitari [and others]
  • Protein fractionation and enrichment prior to proteomics sample preparation / Andrew J. Alpert
  • Sample preparation for mass spectrometry-based proteomics; from proteomes to peptides / John C. Rogers, Ryan D. Bomgarden
  • Plant structure and specificity: challenges and sample preparation considerations for proteomics / Sophie Alvarez, Michael J. Naldrett
  • Improving proteome coverage by reducing sample complexity via chromatography / Uma Kota, Mark L. Stolowitz
  • Mass spectrometry for proteomics analysis. Database search engines: paradigms, challenges and solutions / Kenneth Verheggen, Lennart Martens, Frode S. Berven, Harald Barsnes, Marc Vaudel
  • Mass analyzers and mass spectrometers / Anthony M. Haag
  • Top-down mass spectrometry: proteomics to proteoforms / Steven M. Patrie
  • Bioinfomatic tools for proteomics data analysis and interpretation. Platforms and pipelines for proteomics data analysis and management / Marius Cosmin Codrea, Sven Nahnsen
  • Tandem mass spectrum sequencing: an alternative to database search engines in shotgun proteomics / Thilo Muth, Erdmann Rapp, Frode S. Berven, Harald Barsnes, Marc Vaudel
  • Visualization, inspection and interpretation of shotgun proteomics identification results / Ragnhild R. Lereim, Eystein Oveland, Frode S. Berven, Marc Vaudel, Harald Barsnes
  • Protein inference / Zengyou He, Ting Huang, Can Zhao, Ben Teng
  • Modification site localization in peptides / Robert J. Chalkley
  • Useful web resources / Andre Bui, Maria D. Person
  • Mass spectrometry-based protein quantification / Yun Chen, Fuqiang Wang, Feifei Xu, Ting Yang
  • Bioinformatics tools for proteomics data interpretation / Karla Grisel Calderón-González, Jesús Hernández-Monge, María Esther Herrera-Aguirre [and others]
  • Applications of proteomis technologies in biological and medical sciences. Identification, quantification, and site localization of protein posttranslational modifications via mass spectrometry-based proteomics / Mi Ke, Hainan Shen, Linjue Wang, Shusheng Luo, Lin Lin, Jie Yang, Ruijun Tian
  • Protein-protein interaction detection via mass spectrometry-based proteomics / Benedetta Turriziani, Alexander von Kriegsheim, Stephen R. Pennington
  • Protein structural analysis via mass spectrometry-based proteomics / Antonio Artigues, Owen W. Nadeau, Mary Ashley Rimmer, Maria T. Villar, Xiuxia Du [and others]
  • Introduction to clinical proteomics / John E. Wiktorowicz, Allan R. Brasier
  • Clinical proteomics. Discovery of candidate biomarkers / John E. Wiktorowicz, Kizhake V. Soman
  • Statistical approaches to candidate biomarker panel selection / Heidi M. Spratt, Hyunsu Ju
  • Qualification and verification of protein biomarker candidates / Yingxin Zhao, Allan R. Brasier
  • Protocol for standardizing high-to-moderate abundance protein biomarker assessments through an mrm-with-standard-peptides quantitative approach / Andrew J. Percy, Juncong Yang, Andrew G. Chambers, Yassene Mohammed, Tasso Miliotis [and others].
Medical Library (Lane)
Book
xi, 213 pages : illustrations (some color) ; 27 cm.
  • Current status and future prospects of mass spectrometry imaging of small molecules / Victoria L. Brown and Lin He
  • Sample preparation for 3D SIMS chemical imaging of cells / Nicholas Winograd and Anna Bloom
  • TOF-SIMS imaging of lipids on rat brain sections / David Touboul and Alain Brunelle
  • MALDI-MS-assisted molecular imaging of metabolites in legume plants / Erin Gemperline and Lingjun Li
  • MALDI mass spectrometry imaging of lipids and primary metabolites on rat brain sections / David Touboul and Alain Brunelle
  • Multiplex MALDI-MS imaging of plant metabolites using a hybrid MS system / Andrew R. Korte [and 3 others]
  • DESI imaging of small molecules in biological tissues / Elaine C. Cabral and Demian R. Ifa
  • Desorption electrospray ionization imaging of small organics on mineral surfaces / Rachel V. Bennett and Facundo M. Fernández-- Imaging of plant materials using indirect desoprtion electrospray ionization mass spectrometry / Christian Janfelt
  • Imaging of lipids and metabolites using nanospray desorption electropray ionization mass spectrometry / Ingela Lanekoff and Julia Laskin
  • Electrospray laser desorption ionization (ELDI) mass spectrometry for molecular imaging of small molecules on tissues / Min-Zong Huang, Siou-Sian Jhang, and Jentaie Shiea
  • Automated cell-by-cell tissue imaging and single-cell analysis for targeted morphologies by laser ablation electrospray ionization mass spectrometry / Hang Li [and 4 others]
  • Laser ablation sample transfer for mass spectrometry imaging / Sung-Gun Park and Kermit K. Murray
  • Nanostructure imaging mass spectrometry : the role of fluorocarbons in metabolite analysis and yoctomole level sensitivity / Michael E. Kurczy [and 3 others]
  • Nanostructure-initiator mass spectrometry (NIMS) for molecular mapping of animal tissues / Tara N. Moening, Victoria L. Brown, and Lin He
  • Nanoparticle-assisted laser desorption/ionization for metabolite imaging / Michihiko Waki [and 4 others]
  • Matrix-enhanced surface-assisted laser desorption/ionization mass spectrometry (ME-SALDI-MS) for mass spectrometry imaging of small molecules / Victoria L. Brown, Qiang Liu, and Lin He
  • Laser desorption postionization mass spectrometry imaging of biological targets / Artem Akhmetov, Chhavi Bhardwaj, and Luke Hanley
  • Data processing and analysis for mass spectrometry imaging / Jiangjiang Liu, Xingchuang Xiong, and Zheng Ouyang.
Mass Spectroscopy Imaging (MSI) has emerged as an enabling technique to provide insight into the molecular entities within cells, tissues and whole-body samples and to understand inherent complexities within biological metabolomes. In Mass Spectrometry Imaging of Small Molecules: Methods and Protocols, experts in the MSI field present techniques for 2D and 3D visualization and quantification of a wide array of small molecular species present in biologically relevant samples. Chapters provide detailed operational instructions from sample preparation to method selection, from comparative quantification to structural identification and from data collection to visualization of small molecule mapping in complex samples. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Mass Spectrometry Imaging of Small Molecules: Methods and Protocols aims to bring the rapidly maturing methods of metabolic imaging to life science researchers and to minimize technical intimidation in adapting new technological platforms in biological research.
(source: Nielsen Book Data)9781493913565 20160618
Science Library (Li and Ma)
Book
xvi, 600 pages : illustrations (some color) ; 24 cm
  • Mass spectrometry for proteomics-based investigation / Alisa G. Woods, Izabela Sokolowska, Armand G. Ngounou Wetie, Kelly Wormwood, Roshanak Aslebagh, Sapan Patel, and Costel C. Darie
  • MALDI profiling and applications in medicine / Ed Dudley
  • Simplifying the proteome: analytical strategies for improving peak capacity / Lee A. Gethings and Joanne B. Connolly
  • Quantitative shotgun proteomics with data-independent acquisition and traveling wave ion mobility spectrometry: a versatile tool in the life sciences / Lewis M. Brown
  • Stable isotope labeling by amino acids in cell culture (SILAC) for quantitative proteomics / Esthelle Hoedt, Guoan Zhang, and Thomas A. Neubert
  • Utility of computational structural biology in mass spectrometry / Urmi Roy, Alisa G. Woods, Izabela Sokolowska, and Costel C. Darie
  • Affinity-mass spectrometry approaches for elucidating structures and interactions of protein-ligand complexes / Brînduşa Alina Petre
  • Neurological analyses: focus on gangliosides and mass spectrometry / Alina D. Zamfir
  • Mass spectrometric analysis of post-translational modifications (PTMs) and protein-protein interactions (PPIs) / Armand G. Ngounou Wetie, Alisa G. Woods, and Costel C. Darie
  • Applications for mass spectrometry in the study of ion channel structure and function / Damien S.K. Samways
  • A mass spectrometry view of stable and transient protein interactions / Hanna G. Budayeva and Ileana M. Cristea
  • Mass spectrometry-based tissue imaging of small molecules / Carly N. Ferguson, Joseph W.M. Fowler, Jonathan F. Waxer, Richard A. Gatti, and Joseph A. Loo
  • Redox proteomics: from bench to bedside / Karina Ckless
  • Analysis of fluorinated proteins by mass spectrometry / Linda A. Luck
  • Mass spectrometry for proteomics-based investigation using the zebrafish vertebrate model system / Reshica Baral, Armand G. Ngounou Wetie, Costel C. Darie, and Kenneth N. Wallace
  • Mass spectrometry-based biomarkers in drug development / Ronald A. Miller and Daniel S. Spellman
  • Detection of biomedically relevant stilbenes from wines by mass spectrometry / Veronica Andrei, Armand G. Ngounou Wetie, Iuliana Mihai, Costel C. Darie, and Alina Vasilescu
  • Mass spectrometric DNA adduct quantification by multiple reaction monitoring and its future use for the molecular epidemiology of cancer / Bernhard H. Monien
  • Using breast milk to assess breast cancer risk: the role of mass spectrometry-based proteomics / Sallie S. Schneider, Roshanak Aslebagh, Armand G. Ngounou Wetie, Susan R. Sturgeon, Costel C. Darie, and Kathleen F. Arcaro
  • Cancer secretomes and their place in supplementing other hallmarks of cancer / Sapan Patel, Armand G. Ngounou Wetie, Costel C. Darie, and Bayard D. Clarkson
  • Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation / Cristinel Sandu, Armand G. Ngounou Wetie, Costel C. Darie, and Hermann Steller
  • Using proteomics to unravel the mysterious steps of the HBV-life-cycle / Norica Branza-Nichita, Catalina Petrareanu, Catalin Lazar, Izabela Sokolowska, and Costel C. Darie
  • Oxidative stress and antibiotic resistance in bacterial pathogens: state of the art, methodologies, and future trends / Mouna Marrakchi, Xiaobo Liu, and Silvana Andreescu
  • Proteomic approaches to dissect neuronal signaling pathways / Heather L. Bowling and Katrin Deinhardt
  • Investigating a Novel Protein Using Mass Spectrometry: The Example of Tumor Differentiation Factor (TDF) / Alisa G. Woods, Izabela Sokolowska, Katrin Deinhardt, and Costel C. Darie
  • Mass spectrometry for the study of autism and neurodevelopmental disorders / Armand G. Ngounou Wetie, Robert M. Dekroon, Mihaela Mocanu, Jeanne P. Ryan, Costel C. Darie, and Alisa G. Woods
  • Biomarkers in major depressive disorder: the role of mass spectrometry / Alisa G. Woods, Dan V. Iosifescu, and Costel C. Darie
  • Application of mass spectrometry to characterize localization and efficacy of nanoceria in vivo / Karin L. Heckman, Joseph Erlichman, Ken Reed, and Matthew Skeels
  • Bottlenecks in proteomics / Armand G. Ngounou Wetie, Devon A. Shipp, and Costel C. Darie.
"This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine"--Publisher's description.
Medical Library (Lane)
Book
online resource (xi, 213 pages) : illustrations (some color) ; 27 cm
  • Current status and future prospects of mass spectrometry imaging of small molecules / Victoria L. Brown and Lin He
  • Sample preparation for 3D SIMS chemical imaging of cells / Nicholas Winograd and Anna Bloom
  • TOF-SIMS imaging of lipids on rat brain sections / David Touboul and Alain Brunelle
  • MALDI-MS-assisted molecular imaging of metabolites in legume plants / Erin Gemperline and Lingjun Li
  • MALDI mass spectrometry imaging of lipids and primary metabolites on rat brain sections / David Touboul and Alain Brunelle
  • Multiplex MALDI-MS imaging of plant metabolites using a hybrid MS system / Andrew R. Korte [and 3 others]
  • DESI imaging of small molecules in biological tissues / Elaine C. Cabral and Demian R. Ifa
  • Desorption electrospray ionization imaging of small organics on mineral surfaces / Rachel V. Bennett and Facundo M. Fernández-- Imaging of plant materials using indirect desoprtion electrospray ionization mass spectrometry / Christian Janfelt
  • Imaging of lipids and metabolites using nanospray desorption electropray ionization mass spectrometry / Ingela Lanekoff and Julia Laskin
  • Electrospray laser desorption ionization (ELDI) mass spectrometry for molecular imaging of small molecules on tissues / Min-Zong Huang, Siou-Sian Jhang, and Jentaie Shiea
  • Automated cell-by-cell tissue imaging and single-cell analysis for targeted morphologies by laser ablation electrospray ionization mass spectrometry / Hang Li [and 4 others]
  • Laser ablation sample transfer for mass spectrometry imaging / Sung-Gun Park and Kermit K. Murray
  • Nanostructure imaging mass spectrometry : the role of fluorocarbons in metabolite analysis and yoctomole level sensitivity / Michael E. Kurczy [and 3 others]
  • Nanostructure-initiator mass spectrometry (NIMS) for molecular mapping of animal tissues / Tara N. Moening, Victoria L. Brown, and Lin He
  • Nanoparticle-assisted laser desorption/ionization for metabolite imaging / Michihiko Waki [and 4 others]
  • Matrix-enhanced surface-assisted laser desorption/ionization mass spectrometry (ME-SALDI-MS) for mass spectrometry imaging of small molecules / Victoria L. Brown, Qiang Liu, and Lin He
  • Laser desorption postionization mass spectrometry imaging of biological targets / Artem Akhmetov, Chhavi Bhardwaj, and Luke Hanley
  • Data processing and analysis for mass spectrometry imaging / Jiangjiang Liu, Xingchuang Xiong, and Zheng Ouyang.
Medical Library (Lane)
Book
xvi, 360 pages : illustrations.
  • Overview of mass spectrometry-based metabolomics : opportunities and challenges
  • Global metabolic profiling using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
  • LC-MS profiling to link metabolic and phenotypic diversity in plant mapping populations
  • Mitochondrial metabolomics using high-resolution Fourier-transform mass spectrometry
  • Sample preparation methods for LC-MS-based global aqueous metabolite profiling
  • Methods of discovery-based and targeted metabolite analysis by comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection
  • Analysis of mouse liver metabolites by GC x GC-TOF MS
  • Metabolite fingerprinting by capillary electrophoresis-mass spectrometry
  • Quantitative metabolomic profiling using dansylation isotope labeling and liquid chromatography mass spectrometry
  • Quantitative analysis of amino and organic acids by methyl chloroformate derivatization and GC-MS/MS analysis
  • Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS
  • Multiplexed, quantitative, and targeted metabolite profiling by LC-MS/MRM
  • Multidimensional mass spectrometry-based shotgun lipidomics
  • Comprehensive quantitative determination of PUFA-related bioactive lipids for functional lipidomics using high-resolution mass spectrometry
  • Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids : application to serum, liver tissue, and cultured cells of different species
  • Analysis of volatile organic compounds in exhaled breath by gas chromatography-mass spectrometry combined with chemometric analysis
  • Headspace SPME-GC-MS metabolomics analysis of urinary volatile organic compounds (VOCs)
  • Metabolite profiling by direct analysis in real-time mass spectrometry
  • Analysis of dried blood spots using DESI mass spectrometry
  • DESI-MS imaging of lipids and metabolites from biological samples
  • Metabolic imaging using nanostructure-initiator mass spectrometry (NIMS)
  • Statistical analysis and modeling of mass spectrometry-based metabolomics data.
Metabolomics is a fast growing field in systems biology and offers a powerful and promising approach for a large range of applications. Metabolomics focuses on deriving the concentrations and fluxes of low molecular weight metabolites in bio-fluids, cells or tissue, plants, foods and related samples and this information provides enormous detail on biological systems and their current status. Mass Spectrometry in Metabolomics: Methods and Protocols presents a broad coverage of the major mass spectrometry (MS)-based metabolomics methods and applications. MS is one of most powerful and commonly used analytical methods in metabolomics; because so many different MS systems are used in metabolomics, this volume includes a wide variety such as triple quads, time of flight, Fourier transform ion cyclotron resonance and even simple quadrupole systems. A wide range of studies are described, with samples ranging from blood and urine to tissue and even plants. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Mass Spectrometry in Metabolomics: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies in an effort to further the dynamic field of metabolomics.
(source: Nielsen Book Data)9781493912575 20160618
Science Library (Li and Ma)
Book
online resource (xvi, 360 pages) : illustrations (some color) ; 26 cm
  • Overview of mass spectrometry-based metabolomics : opportunities and challenges
  • Global metabolic profiling using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
  • LC-MS profiling to link metabolic and phenotypic diversity in plant mapping populations
  • Mitochondrial metabolomics using high-resolution Fourier-transform mass spectrometry
  • Sample preparation methods for LC-MS-based global aqueous metabolite profiling
  • Methods of discovery-based and targeted metabolite analysis by comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection
  • Analysis of mouse liver metabolites by GC x GC-TOF MS
  • Metabolite fingerprinting by capillary electrophoresis-mass spectrometry
  • Quantitative metabolomic profiling using dansylation isotope labeling and liquid chromatography mass spectrometry
  • Quantitative analysis of amino and organic acids by methyl chloroformate derivatization and GC-MS/MS analysis
  • Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS
  • Multiplexed, quantitative, and targeted metabolite profiling by LC-MS/MRM
  • Multidimensional mass spectrometry-based shotgun lipidomics
  • Comprehensive quantitative determination of PUFA-related bioactive lipids for functional lipidomics using high-resolution mass spectrometry
  • Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids : application to serum, liver tissue, and cultured cells of different species
  • Analysis of volatile organic compounds in exhaled breath by gas chromatography-mass spectrometry combined with chemometric analysis
  • Headspace SPME-GC-MS metabolomics analysis of urinary volatile organic compounds (VOCs)
  • Metabolite profiling by direct analysis in real-time mass spectrometry
  • Analysis of dried blood spots using DESI mass spectrometry
  • DESI-MS imaging of lipids and metabolites from biological samples
  • Metabolic imaging using nanostructure-initiator mass spectrometry (NIMS)
  • Statistical analysis and modeling of mass spectrometry-based metabolomics data.
Medical Library (Lane)
Book
1 online resource (326 pages) : illustrations
  • Introduction.- Applications of XPS in Biology and Biointerface Analysis.- Biomolecular Analysis by Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS).- Cluster Secondary Ion Mass Spectrometry.- Biological Tissue Imaging at Different Levels: MALDI and SIMS Imaging Combined.- Molecular Structure and Identification Through G-SIMS and SMILES.- Imaging with the Helium Ion Microscope.- Sum Frequency Generation Vibrational Spectroscopy: A Sensitive Technique for the Study of Biological Molecules at Interfaces.- Near-Field Scanning Optical Microscopy: A New Tool for Exploring Biological Structure and Function in Biology.- Atomic Force Microscopy: Applications in the Field of Biology.- Multi-technique Characterization of DNA-modified Surfaces for Biosensing and Diagnostic Applications.
  • (source: Nielsen Book Data)9783319013596 20160613
This book summarizes the main surface analysis techniques that are being used to study biological specimens/systems. The compilation of chapters in this book highlight the benefits that surface analysis provides. The outer layer of bulk solid or liquid samples is referred to as the surface of the sample/material. At the surface, the composition, microstructure, phase, chemical bonding, electronic states, and/or texture is often different than that of the bulk material. The outer surface is where many material interactions/reactions take place. This is especially true biomaterials which may be fabricated into bio-devices and in turn implanted into tissues and organs. Surfaces of biomaterials (synthetic or modified natural materials) are of critical importance since the surface is typically the only part of the biomaterial/bio-device that comes in contact with the biological system. Analytical techniques are required to characterize the surface of biomaterials and quantify their impact in real-world biological systems. Surface analysis of biological materials started in the 1960's and the number of researchers working in this area have increased very rapidly since then, a number of advances have been made to standard surface analytical instrumentation, and a number of new instruments have been introduced.
(source: Nielsen Book Data)9783319013596 20160613
Book
x, 405 p. : ill. (some col.) ; 26 cm.
  • 1. Introduction to Mass Spectrometry-Based Proteomics Rune Matthiesen and Jakob Bunkenborg 2. LC-MS Spectra Processing Rune Matthiesen 3. Isotopic Distributions Alan L. Rockwood and Magnus Palmblad 4. Retention Time Prediction and Protein Identification Alex A. Henneman and Magnus Palmblad 5. Algorithms for Database Dependent Search of MSMS Data Rune Matthiesen 6. Interpretation of Tandem Mass Spectra of Post-Translationally Modified Peptides Jakob Bunkenborg and Rune Matthiesen 7. Improving Peptide Identification Using Empirical Scoring Systems Robert J. Chalkley 8. Methods and Algorithms for Quantitative Proteomics by Mass Spectrometry Rune Matthiesen and Ana Sofia Carvalho 9. Computational Approaches to Selected Reaction Monitoring (SRM) Assay Design Conrad Bessant and Jun Fan 10. Feature Selection and Machine Learning with Mass Spectrometry Data Susmita Datta 11. Considerations in the Analysis of Hydrogen Exchange Mass Spectrometry Data Thomas E. Wales, Michael J. Eggertson, and John R. Engen 12. Permethylated N-Glycan Analysis with Mass Spectrometry Zhenxin Lin and David M. Lubman 13. Mass Spectrometry Methods for Studying Glycosylation in Cancer Hugo Osorio and Celso A. Reis 14. Proteomics Data Exchange and Storage: The Need for Common Standards and Public Repositories Rafael C. Jimenez and Juan Antonio Vizcaino 15. Tools for Protein Post Translational Modifications Analysis: FAK, A Case Study Catarina Fonseca, Paula Voabil, Ana Sofia Carvalho, and Rune Matthiesen 16. Proteomic Strategies to Characterize Signaling Pathways H.C. Harsha, Sneha M. Pinto, and Akhilesh Pandey 17. Simple Proteomics Data Analysis in the Object-Oriented PowerShell Yassene Mohammed and Magnus Palmblad.
  • (source: Nielsen Book Data)9781627033916 20160612
Since the publishing of the first edition, the methodologies and instrumentation involved in the field of mass spectrometry-based proteomics has improved considerably. Fully revised and expanded, Mass Spectrometry Data Analysis in Proteomics, Second Edition presents expert chapters on specific MS-based methods or data analysis strategies in proteomics. The volume covers data analysis topics relevant for quantitative proteomics, post translational modification, HX-MS, glycomics, and data exchange standards, among other topics. Written in the highly successful Methods in Molecular Biology series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Updated and authoritative, Mass Spectrometry Data Analysis in Proteomics, Second Edition serves as a detailed guide for all researchers seeking to further our knowledge in the field of proteomics.
(source: Nielsen Book Data)9781627033916 20160612
Science Library (Li and Ma)
Book
online resource (x, 405 pages) : illustrations (some color).
  • Introduction to mass spectrometry-based proteomics / Rune Matthiesen and Jakob Bunkenborg
  • LC-MS spectra processing / Rune Matthiesen
  • Isotopic distributions / Alan L. Rockwood and Magnus Palmblad
  • Retention time prediction and protein identification / Alex A. Henneman and Magnus Palmblad
  • Algorithms for database-dependent search of MS/MS data / Rune Matthiesen
  • Interpretation of tandem mass spectra of posttranslationally modified peptides / Jakob Bunkenborg and Rune Matthiesen
  • Improving peptide identification using empirical scoring systems / Robert J. Chalkley
  • Methods and algorithms for quantitative proteomics by mass spectrometry / Rune Matthiesen and Ana Sofia Carvalho
  • Computational approaches to selected reaction monitoring assay design / Conrad Bessant and Jun Fan
  • Feature celection and machine learning with mass spectrometry data / Susmita Datta
  • Considerations in the analysis of hydrogen exchange mass spectrometry data / Thomas E. Wales, Michael J. Eggertson, and John R. Engen
  • Permethylated n-glycan analysis with mass spectrometry / Zhenxin Lin and David M. Lubman
  • Mass spectrometry methods for studying glycosylation in cancer / Hugo Osorio and Celso A. Reis
  • Proteomics data exchange and storage : the need for common standards and public repositories / Rafael C. Jimenez and Juan Antonio Vizcaıno
  • Tools for protein posttranslational modifications analysis : FAK, a case study / Catarina Fonseca [and others]
  • Proteomic strategies to characterize signaling pathways / H.C. Harsha, Sneha M. Pinto, and Akhilesh Pandey
  • Simple proteomics data analysis in the object-oriented powershell / Yassene Mohammed and Magnus Palmblad.
Since the publishing of the first edition, the methodologies and instrumentation involved in the field of mass spectrometry-based proteomics has improved considerably. Fully revised and expanded, Mass Spectrometry Data Analysis in Proteomics, Second Edition presents expert chapters on specific MS-based methods or data analysis strategies in proteomics. The volume covers data analysis topics relevant for quantitative proteomics, post translational modification, HX-MS, glycomics, and data exchange standards, among other topics. Written in the highly successful Methods in Molecular Biology series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Updated and authoritative, Mass Spectrometry Data Analysis in Proteomics, Second Edition serves as a detailed guide for all researchers seeking to further our knowledge in the field of proteomics.
Medical Library (Lane)
Book
online resource (xii, 461 pages, [16] pages of plates) : illustrations (some color).
  • 1. Overview of the various types of mass spectrometers that are used in drug discovery and drug development / Gerard Hopfgartner
  • 2. Utility of high resolution mass spectrometry for new drug discovery applications / William Bart Emary and Nanyan Rena Zhang
  • 3. Quantitative mass spectrometry considerations in a regulated environment / Mohammed Jemal and Yuan-Qing Xia
  • 4. Mass spectrometry for quantitative in vitro ADME assays / Jun Zhang and Wilson Z. Shou
  • 5. Metabolite identification using mass spectrometry in drug development / Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash
  • 6. MS analysis of biological drugs, proteins, and peptides / Yi Du, John Mehl, and Pavlo Pristatsky
  • 7. Characterization of impurities and degradation products in small molecule pharmaceuticals and biologics / Hui Wei, Guodong Chen and Adrienne A. Tymiak
  • 8. Liquid extraction surface analysis (LESA) : a new mass spectrometry-based technique for ambient surface profiling / Dan Eikel and Jack Henion
  • 9. MS applications in support of medicinal chemistry sciences / Maarten Honing, Benno Ingelse, and Birendraÿ N. Pramanik
  • 10. Imaging mass spectrometry of proteins and peptides / Michelle L. Reyzer and Richard M. Caprioli
  • 11. Imaging mass spectrometry for drugs and metabolites / Stacey R. Oppenheimer
  • 12. Screening reactive metabolites : role of liquid chromatography-high resolution mass spectrometry in combination with 'intelligent' data mining tools / Shuguang Ma and Swapan K. Chowdhury
  • 13. Mass spectrometry of siRNA / Mark Cancilla and Mike Flanagan
  • 14. Mass spectrometry for metabolomics / Petia Shipkova and Michael D. Reily
  • 15. Quantitative analysis of peptides with mass spectrometry : selected reaction monitoring or high resolution full scan? / Lieve Dillen and Filip Cuyckens.
Medical Library (Lane)
Book
xi, 339 pages : illustrations ; 26 cm.
  • Introduction to glycosylation and mass spectrometry / Steven M. Patrie, Michael J. Roth, and Jennifer J. Kohler
  • PART I ENRICHMENT AND ISOLATION METHODS
  • Tandem lectin weak affinity chromatography for glycoprotein enrichment / Zhi Yuan Ma, Yuliya Skorobogatko, and Keith Vosseller
  • CSC technology: Selective labeling of glycoproteins by mild oxidation to phenotype cells / Andreas Hofmann, Damaris Bausch-Fluck, and Bernd Wollscheid
  • Use of boronic acid nanoparticles in glycoprotein enrichment / Yawei Xu, Lijuan Zhang, and Haojie Lu
  • Incorporation of unnatural sugars for the identification of glycoproteins / Balyn W. Zaro, Howard C. Hang, and Matthew R. Pratt
  • Characterization of membrane-associated glycoproteins using lectin affinity chromatography and mass spectrometry / Yashu Liu, Jintang He, and David M. Lubman
  • Sialic acid capture-and-release and LC-MS(n) analysis of glycopeptides / Jonas Nilsson and Göran Larson
  • PART II SAMPLE PREPARATION
  • In-solution digestion of glycoproteins for glycopeptide-based mass analysis / Eden P. Go, Kathryn R. Rebecchi, and Heather Desaire
  • Nano-HPLC-MS of glycopeptides obtained after nonspecific proteolysis / Gerhild Zauner, Carolien A.M. Koeleman, André M. Deelder, and Manfred Wuhrer
  • PART III SEPARATION METHODS
  • Glycopeptide enrichment for MALDI-TOF mass spectrometry analysis by hydrophilic interaction liquid chromatography solid phase extraction (HILIC SPE) / Pia Hønnerup Jensen, Simon Mysling, Peter Højrup, and Ole Nørregaard Jensen
  • Separation and identification of glycoforms by capillary electrophoresis with electrospray ionization mass spectrometric detection / Alina D. Zamfir, Corina Flangea, Alina Serb, Ana-Maria Zagrean, Andreas M. Rizzi, and Eugen Sisu
  • Structural separations by ion mobility-MS for glycomics and glycoproteomics / Larissa S. Fenn and John A. McLean
  • PART IV QUANTITATION METHODS
  • Quantitative analysis of glycoprotein glycans / Ron Orlando
  • Stable isotope labeling of N-glycosylated peptides by enzymatic deglycosylation for mass spectrometry-based glycoproteomics / Hiroyuki Kaji and Toshiaki Isobe
  • Approaches for site mapping and quantification of o-linked glycopeptides / Peng Zhao, Stephanie H. Stalnaker, and Lance Wells
  • Glycan profiling: Label-free analysis of glycoproteins / Yoshinao Wada
  • PART V COMPUTATIONAL TOOLS
  • Introduction to informatics in glycoprotein analysis / Kiyoko F. Aoki-Kinoshita
  • Software tools for glycan profiling / Chuan-Yih Yu, Anoop Mayampurath, and Haixu Tang
  • PART VI CASE STUDIES IN MASS SPECTROMETRY OF GLYCOPROTEINS
  • Quantitative characterization of glycoproteins in neurodegenerative disorders using iTRAQ / Min Shi, Hyejin Hwang, and Jing Zhang
  • Quantitative proteomic analysis of N-linked glycoproteins in human tear fluid / Lei Zhou and Roger W. Beuerman
  • Elucidation of N-glycosites within human plasma glycoproteins for cancer biomarker discovery / Penelope Drake, Birgit Schilling, Brad Gibson, and Susan Fisher
  • Characterizing the glycosylation state of therapeutic recombinant glycoproteins. / Nicole Samuels, David Kates, Jun Liu, and Joanne Severs.
Glycosylation is the most abundant post-translational modification of proteins. Estimates vary widely, but a common assessment is that upwards of 50% of eukaryotic proteins are modified by some type of glycan. In Mass Spectrometry of Glycoproteins: Methods and Protocols, expert researchers in the field detail many of the methods that are now commonly used for glycoproteomics. These methods and techniques include robust sample preparation techniques; advanced chromatographic strategies for improving dynamic range; state-of-the-art mass spectrometry instrumentation and associated ionization and fragmentation methods; and informatics tools used for identifying glycoproteins and characterizing the associated glycans. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mass Spectrometry of Glycoproteins: Methods and Protocol is an essential resource for those who work at the interface of glycobiology and mass spectrometry.
(source: Nielsen Book Data)9781627031455 20160610
Science Library (Li and Ma)
Book
online resource (xi, 339 pages) : illustrations (some color) ; 26 cm
  • Introduction to glycosylation and mass spectrometry / Steven M. Patrie, Michael J. Roth, and Jennifer J. Kohler
  • PART I ENRICHMENT AND ISOLATION METHODS
  • Tandem lectin weak affinity chromatography for glycoprotein enrichment / Zhi Yuan Ma, Yuliya Skorobogatko, and Keith Vosseller
  • CSC technology: Selective labeling of glycoproteins by mild oxidation to phenotype cells / Andreas Hofmann, Damaris Bausch-Fluck, and Bernd Wollscheid
  • Use of boronic acid nanoparticles in glycoprotein enrichment / Yawei Xu, Lijuan Zhang, and Haojie Lu
  • Incorporation of unnatural sugars for the identification of glycoproteins / Balyn W. Zaro, Howard C. Hang, and Matthew R. Pratt
  • Characterization of membrane-associated glycoproteins using lectin affinity chromatography and mass spectrometry / Yashu Liu, Jintang He, and David M. Lubman
  • Sialic acid capture-and-release and LC-MS(n) analysis of glycopeptides / Jonas Nilsson and Göran Larson
  • PART II SAMPLE PREPARATION
  • In-solution digestion of glycoproteins for glycopeptide-based mass analysis / Eden P. Go, Kathryn R. Rebecchi, and Heather Desaire
  • Nano-HPLC-MS of glycopeptides obtained after nonspecific proteolysis / Gerhild Zauner, Carolien A.M. Koeleman, André M. Deelder, and Manfred Wuhrer
  • PART III SEPARATION METHODS
  • Glycopeptide enrichment for MALDI-TOF mass spectrometry analysis by hydrophilic interaction liquid chromatography solid phase extraction (HILIC SPE) / Pia Hønnerup Jensen, Simon Mysling, Peter Højrup, and Ole Nørregaard Jensen
  • Separation and identification of glycoforms by capillary electrophoresis with electrospray ionization mass spectrometric detection / Alina D. Zamfir, Corina Flangea, Alina Serb, Ana-Maria Zagrean, Andreas M. Rizzi, and Eugen Sisu
  • Structural separations by ion mobility-MS for glycomics and glycoproteomics / Larissa S. Fenn and John A. McLean
  • PART IV QUANTITATION METHODS
  • Quantitative analysis of glycoprotein glycans / Ron Orlando
  • Stable isotope labeling of N-glycosylated peptides by enzymatic deglycosylation for mass spectrometry-based glycoproteomics / Hiroyuki Kaji and Toshiaki Isobe
  • Approaches for site mapping and quantification of o-linked glycopeptides / Peng Zhao, Stephanie H. Stalnaker, and Lance Wells
  • Glycan profiling: Label-free analysis of glycoproteins / Yoshinao Wada
  • PART V COMPUTATIONAL TOOLS
  • Introduction to informatics in glycoprotein analysis / Kiyoko F. Aoki-Kinoshita
  • Software tools for glycan profiling / Chuan-Yih Yu, Anoop Mayampurath, and Haixu Tang
  • PART VI CASE STUDIES IN MASS SPECTROMETRY OF GLYCOPROTEINS
  • Quantitative characterization of glycoproteins in neurodegenerative disorders using iTRAQ / Min Shi, Hyejin Hwang, and Jing Zhang
  • Quantitative proteomic analysis of N-linked glycoproteins in human tear fluid / Lei Zhou and Roger W. Beuerman
  • Elucidation of N-glycosites within human plasma glycoproteins for cancer biomarker discovery / Penelope Drake, Birgit Schilling, Brad Gibson, and Susan Fisher
  • Characterizing the glycosylation state of therapeutic recombinant glycoproteins. / Nicole Samuels, David Kates, Jun Liu, and Joanne Severs.
Medical Library (Lane)
Book
xii, 627 p. : ill. (some col.) ; 26 cm.
  • List of contributors-- Part I. Basic Methodological Strategies in Metabolomic Research: 1. Exploring the human metabolome by nuclear magnetic resonance spectroscopy and mass spectroscopy-- 2. Methodological requirements for lipidomics research-- 3. Biological methods for metabolic research-- Part II. Metabolomic Mass Spectrometry: Experimental Techniques and Bioinformatics: 4. Considerations in sample preparation, collection, and extraction approaches applied in microbial, plant, and mammalian metabolic profiling-- 5. Mass spectrometry-based methodologies for single-cell metabolite detection and identification-- 6. Direct metabolomics from tissues and cells: laser ablation electrospray ionization for small molecule and lipid characterization-- 7. Bioinformatic approaches to processing and annotation of high-resolution mass spectrometry data-- 8. Approaches for natural product detection and structural elucidation using mass spectrometry with high mass accuracy-- 9. Metabolomics using ion mobility mass spectrometry-- 10. Metabolomics via biomedical mass spectrometry: from sampling to clinical applications-- Part III. Metabolomics of Biofluids: Nuclear Magnetic Resonance Spectroscopy and Chemometrics: 11. Analytical techniques in metabolomics integrating nuclear magnetic resonance spectroscopy and chromatography with mass spectrometry-- 12. Chemometric methods in nuclear magnetic resonance-based body fluid analysis-- 13. Nuclear magnetic resonance of cerebrospinal fluid: the neurometabolome-- 14. Nuclear magnetic resonance-based saliva metabolomics-- 15. Nuclear magnetic resonance methods for metabolomic investigation of amniotic fluid-- 16. Nuclear magnetic resonance analysis and genetic metabolic disease-- 17. Lipid profiling in health and disease-- Part IV. Metabolomic Nuclear Magnetic Resonance Spectroscopy Techniques for Body Tissue Analysis: 18. Magnetic resonance spectroscopy in investigating the cancer metabolome in preclinical model systems-- 19. Phospholipidomics by phosphorous nuclear magnetic resonance spectroscopy of tissue extracts-- 20. Carbon-13 nuclear magnetic resonance for analysis of metabolic pathways-- 21. Hyperpolarized nuclear magnetic resonance spectroscopy - a new method for metabolomic research-- 22. Metabolomic magnetic resonance spectroscopy of human tissues: comparison of in vivo and high-resolution magic angle spinning ex vivo techniques-- 23. Reproducible sample preparation and spectrum acquisition techniques for metabolic profiling of human tissues by proton high-resolution magic angle spinning nuclear magnetic resonance-- 24. Assignment strategies for nuclear magnetic resonances in metabolomics research-- Index.
  • (source: Nielsen Book Data)9780521765909 20160611
Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.
(source: Nielsen Book Data)9780521765909 20160611
Science Library (Li and Ma)
Book
online resource (xi, 320 pages) : illustrations (some color) cm
  • Affinity depletion of plasma and serum for mass spectrometry-based proteome analysis / Julian A.J. Jaros ... [et al.]
  • Tissue sample preparation for biomarker discovery / Yoshiyuki Suehara, Daisuke Kubota, and Tsuyoshi Saito
  • Subcellular fractionation for identification of biomarkers : serial detergent extraction by subcellular accessibility and solubility / Sun-II Hwang and David K. Han
  • Analysis of secreted proteins / Valeria Severino, Annarita Farina, and Angela Chambery
  • Preparation of human cerebrospinal fluid for proteomics biomarker analysis / Timothy J. Waybright
  • Proteomic analysis of frozen tissue samples using laser capture microdissection / Sumana Mukherjee ... [et al.]
  • Use of formalin-fixed, paraffin-embedded tissue for proteomic biomarker discovery / David B. Krizman and Jon Burrows
  • Phosphopeptide enrichment using offline titanium dioxide columns for phosphoproteomics / Li-Rong Yu and Timothy Veenstra
  • iTRAQ-labeling for biomarker discovery / Leroi V. DeSouza, Sébastien N. Voisin, and K.W. Michael Siu
  • Analysis of glycoproteins for biomarker discovery / Jintang He ... [et al.]
  • SILAC in biomarker discovery / Benjamin C. Orsburn
  • Trypsin-mediated 18O/16O labeling for biomarker discovery / Xiaoying Ye ... [et al.]
  • Two-dimensional SDS-PAGE fractionation of biological samples for biomarker discovery / Thierry Rabilloud and Sarah Triboulet
  • Informatics of protein and posttranslational modification detection via shotgun proteomics / Jerry D. Holman, Surendra Dasari, and David L. Tabb
  • Quantitation of met tyrosine phosphorylation using MRM-MS / Zhaojing Meng
  • Preparation of human serum for prolactin measurement by multiple reaction monitoring mass spectrometry / Timothy J. Waybright ... [et al.]
  • Label-free quantitative shotgun proteomics using normalized spectral abundance factors / Karlie A. Neilson ... [et al.]
  • Employment of complementary dissociation techniques for body fluid characterization and biomarker discovery / David M. Good and Dorothea Rutishauser
  • Phosphopeptide microarrays for comparative proteomic profiling of cellular lysates / Liqian Gao ... [et al.]
  • Tissue preparation for MALDI-MS imaging of protein and peptides / Simona Colantonio and Roberta M. Smith
  • Plant proteogenomics : from protein extraction to improved gene predictions / Brett Chapman ... [et al.]
  • Label-free differential analysis of murine postsynaptic densities / Scott P. Goulding, Michael J. MacCoss, and Christine C. Wu
  • Fractionation of peptides by strong cation-exchange liquid chromatography / King C. Chan and Haleem J. Issaq.
Medical Library (Lane)
Book
1 online resource (478 p.)
  • PREFACE Walter A. Korfmacher CONTRIBUTORS 1 Overview of the Various Types of Mass Spectrometers that are Used in Drug Discovery and Drug Development 1 Gerard Hopfgartner 2 Utility of High Resolution Mass Spectrometry for New Drug Discovery Applications William Bart Emary and Nanyan Rena Zhang 3 Quantitative Mass Spectrometry Considerations in a Regulated Environment Mohammed Jemal and Yuan-Qing Xia 4 Mass Spectrometry for Quantitative in Vitro ADME Assays Jun Zhang and Wilson Z. Shou 5 Metabolite Identification Using Mass Spectrometry in Drug Development Natalia Penner, Joanna Zgoda-Pols and Chandra Prakash 6 MS Analysis of Biological Drugs, Proteins and Peptides Yi Du, John Mehl and Pavlo Pristatsky 7 Characterization of Impurities and Degradation Products in Small Molecule Pharmaceuticals and Biologics Hui Wei, Guodong Chen and Adrienne A. Tymiak 8 Liquid Extraction Surface Analysis (LESA): a New Mass Spectrometry-Based Technique for Ambient Surface Profiling Dan Eikel and Jack Henion 9 MS Applications in Support of Medicinal Chemistry Sciences Maarten Honing, Benno Ingelse and Birendra N. Pramanik 10 Imaging Mass Spectrometry of Proteins and Peptides Michelle L. Reyzer and Richard M. Caprioli 11 Imaging Mass Spectrometry for Drugs and Metabolites Stacey R. Oppenheimer 12 Screening Reactive Metabolites: Role of Liquid Chromatography-High Resolution Mass Spectrometry in Combination with 'Intelligent' Data Mining Tools Shuguang Ma and Swapan K. Chowdhury 13 Mass Spectrometry of siRNA Mark Cancilla and Mike Flanagan 14 Mass Spectrometry for Metabolomics Petia Shipkova and Michael D. Reily 15 Quantitative Analysis of Peptides with Mass Spectrometry: Selected Reaction Monitoring or High Resolution Full Scan? Lieve Dillen and Filip Cuyckens Index.
  • (source: Nielsen Book Data)9780470942383 20160610
Facilitates the discovery and development of new, effective therapeuticsWith coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics."Mass Spectrometry for Drug Discovery and Drug Development" begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC-high-resolution mass spectrometry for quantitative assaysMass spectrometry for siRNAQuantitative analysis of peptidesMass spectrometry analysis of biological drugsApplications that support medicinal chemistry investigationsMass spectrometry imaging and profilingThroughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field."Mass Spectrometry for Drug Discovery and Drug Development" is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.
(source: Nielsen Book Data)9780470942383 20160610
dx.doi.org Wiley Online Library
Book
online resource (xii, 400 pages) : illustrations ; 26 cm
  • Mass spectrometry-driven proteomics : an introduction / Kenny Helsens [and others]
  • Metabolic labeling of model organisms using heavy nitrogen (15N) / Joost W. Gouw, Bastiaan B.J. Tops, and Jeroen Krijgsveld
  • Trypsin-catalyzed oxygen-18 labeling for quantitative proteomics / Wei-Jun Qian [and others]
  • ICPL labeling strategies for proteome research / Friedrich Lottspeich and Josef Kellermann
  • Quantitative proteome analysis using isobaric peptide termini labeling (IPTL) / Magnus Ø. Arntzen [and others]
  • Complete chemical modification of amine and acid functional groups of peptides and small proteins / Casey J. Krusemark [and others]
  • Production and use of stable isotope-labeled proteins for absolute quantitative proteomics / Dorothée Lebert [and others]
  • Organelle proteomics / Sophie Duclos and Michel Desjardins
  • Membrane protein digestion
  • comparison of LPI HexaLane with traditional techniques / Ping Sui [and others]
  • GeLCMS for in-depth protein characterization and advanced analysis of proteomes / Alicia Lundby and Jesper V. Olsen
  • Exploring new proteome space : combining Lys-N proteolytic digestion and strong cation exchange (SCX) separation in peptide-centric MS-driven proteomics / Nadia Taouatas, Shabaz Mohammed, and Albert J.R. Heck
  • Quantitation of newly synthesized proteins by pulse labeling with azidohomoalanine / Gertjan Kramer [and others]
  • Analytical strategies in mass spectrometry-based phosphoproteomics / Heidi Rosenqvist, Juanying Ye, and Ole N. Jensen
  • Protocol on the use of titanium dioxide chromatography for phosphoproteomics / Martijn W.H. Pinkse, Simone Lemeer, and Albert J.R. Heck
  • Positional proteomics at the N-Terminus as a means of proteome simplification / Gemma R. Davidson, Stuart D. Armstrong, and Robert J. Beynon
  • N-Terminomics : a high-content screen for protease substrates and their cleavage sites / John C. Timmer and Guy S. Salvesen
  • Protease specificity profiling by tandem mass spectrometry using proteome-derived peptide libraries / Oliver Schilling, Ulrich auf dem Keller, and Christopher M. Overall
  • Identification of proteolytic products and natural protein N-Termini by terminal amine isotopic labeling of substrates (TAILS) / Alain Doucet [and others]
  • Lectins as tools to select for glycosylated proteins / Els J.M. Van Damme
  • Strong cation exchange chromatography for analysis of sialylated glycopeptides / Katharina Lohrig, Albert Sickmann, and Urs Lewandrowski
  • Titanium dioxide enrichment of sialic acid-containing glycopeptides / Giuseppe Palmisano, Sara E. Lendal, and Martin R. Larsen
  • Chemical De-O-glycosylation of glycoproteins for applications in LC-based proteomics / Franz-Georg Hanisch
  • Ubiquitination and degradation of proteins / Yelena Kravtsova-Ivantsiv and Aaron Ciechanover
  • Bioinformatics challenges in mass spectrometry-driven proteomics / Lennart Martens
  • Case study on the comparison of different software tools for automated quantification of peptides / Niklaas Colaert [and others].
Medical Library (Lane)
Book
online resource (xx, 589 pages : illustrations ; 24 cm)
  • Aqueous Normal-Phase Chromatography
  • Application of the Calculated Physicochemical Property, Log D, to Hydrophilic Interaction Chromatography in the Bioanalytical Laboratory
  • HILIC Behavior of Reversed-Phase/Ion-Exchange Mixed-Mode Stationary Phases and Their Applications
  • Mechanisms Controlling the Separation and Retention of Proanthocyanidins and Other Plant Polyphenols in Hydrophilic Interaction Chromatography
  • Applications of Hydrophilic Interaction Chromatography to Food Analysis
  • Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry (HILIC-MS) of Paralytic Shellfish Poisoning Toxins, Domoic Acid and Assorted Cyanobacterial Toxins
  • Application of HILIC for Polar Environmental Contaminants (Including Pharmaceuticals) in Aquatic Systems
  • Hydrophilic Interaction Chromatography-Mass Spectrometry
  • Clinical Applications of Hydrophilic Interaction Liquid Chromatography
  • Dimethylarginine Analysis by HILIC-MS/MS and Its Applications in Clinical Chemistry and In Vivo Animal Models
  • Polar Functional Groups for HILIC Method
  • Analysis of Pharmaceutical Impurities Using Hydrophilic Interaction Liquid Chromatography
  • Fast In-Process Method for the Determination of Ioversol and Related Polar Compounds by Hydrophilic Interaction Chromatography (HILIC) and UPLC
  • Retention Behavior of Hydrazine Derivatives in HILIC Mode
  • HILIC Retention Behavior and Method Development for Highly Polar Basic Compounds Used in Pharmaceutical Synthesis
  • Retention of Polar Acidic and Basic Drugs by HILIC
  • Retention and Selectivity of Polar Stationary Phases for Hydrophilic Interaction Chromatography
  • HILIC-MS/MS for the Determination of Polar Bioactive Substances
  • Method Development and Analysis of Mono- and Diphosphorylated Nucleotides by HILIC HPLC-ESI-MS
  • Hydrophilic Interaction Liquid Chromatography-Based Enrichment Protocol Coupled to Mass Spectrometry for Glycoproteome Analysis
  • Development and Application of Methods for Separation of Carbohydrates by Hydrophilic Interaction Liquid Chromatography
  • Hydrophilic Interaction Liquid Chromatography in the Characterization of Glycoproteins
  • Analysis of Protein Glycosylation and Phosphorylation Using HILIC-MS.
Medical Library (Lane)

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