1 online resource (ix, 241 pages) : illustrations (some color).
  • Cost-effective synthesis of chiral chemicals using data-mined enzymes
  • Metabolic regulation of bacterial cells
  • Cell factories for microbial diols
  • Construction of Escherichia coli cell factories for production of bulk chemicals
  • Microbial Cell Factories for Production of Long Chain Alcohols
  • Yeast cell factories based on surface engineering
  • Cell factories of higher fungi for useful metabolite production
  • Role of Microbial Communities in Petroleum Reservoirs.
This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
xvii, 457 pages : illustrations (black and white) ; 26 cm.
  • 1. Introduction to fed-batch bioreactors-- 2. Idealised reactors and fed-batch reactors-- 3. Maximisation of reaction rates and fed-batch operation-- 4. Phenomena that favour fed-batch operations-- 5. Classification and characteristics of fed-batch cultures-- 6. Models based on mass balance equations-- 7. Non-equation-based models-- 8. Experimental determination of specific rates-- 9. Optimization via Pontryagin's maximum principle-- 10. Computational techniques-- 11. Optimization of single and multiple isothermal reactions-- 12. Optimization of fed-batch cultures for cell mass production-- 13. Optimization of fed-batch cultures for metabolites-- 14. Simple, intuitive adaptive optimization-- 15. Measurements, estimation and control-- 16. Feasibility assessment and implementable feed rates.
  • (source: Nielsen Book Data)9780521513364 20160612
Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.
(source: Nielsen Book Data)9780521513364 20160612
Science Library (Li and Ma)
1 online resource (xxx, 561 p.) : ill. (some col.)
  • 1. What is this book about?
  • 2. Chemicals from metabolic pathways
  • 3. Elemental and redox balances
  • 4. Thermodynamics of bioreactions
  • 5. Biochemical reaction networks
  • 6. Enzyme kinetics and metabolic control analysis
  • 7. Growth kinetics of cell cultures
  • 8. Population balance equations
  • 9. Design of fermentation processes
  • 10. Gas-Liquid mass transfer
  • 11. Scale-up of bioprocesses.
xiii, 223 p. : ill. (some col.) ; 24 cm.
  • Rene Brecht: Disposable Bioreactors: Maturation into Pharmaceutical Glycoprotein Manufacturing.- Xiaowei Zhang, Matthieu Stettler, Dario De Sanctis, Marco Perrone, Nicola Parolini, Marco Discacciati, Maria De Jesus, David Hacker, Alfio Quarteroni, and Florian Wurm: Use of Orbital Shaken Disposable Bioreactors for Mammalian Cell Cultures from the Milliliter-Scale to the 1,000-Liter Scale.- Regine Eibl, Soren Werner, and Dieter Eibl: Bag Bioreactor Based on Wave-Induced Motion: Characteristics and Applications.- Regine Eibl and Dieter Eibl: Application of Disposable Bag Bioreactors in Tissue Engineering and for the Production of Therapeutic Agents.- Jean-Paul Ducos , Benedicte Terrier, and Didier Courtois: Disposable Bioreactors for Plant Micropropagation and Mass Plant Cell Culture.- Gerardo Catapano, John F. Patzer II, and Jorg Christian Gerlach : Transport Advances in Disposable Bioreactors for Liver Tissue Engineering.- Anne Glindkamp, Daniel Riechers, Christoph Rehbock, Bernd Hitzmann, Thomas Scheper, and Kenneth F. Reardon: Sensors in Disposable Bioreactors Status and Trends.- Uwe Gottschalk: Disposables in Downstream Processing.- Aline Ravise, Emmanuelle Cameau, Georges De Abreu, and Alain Pralong: Hybrid and Disposable Facilities for Manufacturing of Biopharmaceuticals: Pros and Cons.-.
  • (source: Nielsen Book Data)9783642018718 20160528
xv, 528 p. : ill. ; 26 cm.
  • Bioreaction Engineering - From Bioprocess Design to Systems Biology-- From Cellular Function to Industrial Products-- Biochemical Reactions - A First Look-- Thermodynamics of Biochemical Reactions-- Biochemical Reaction Networks-- Enzyme Kinetics and Metabolic Control Analysis-- Modelling of Growth Kinetics-- Population Balance Equations-- Design of Fermentation Processes-- Mass Transfer-- Scale-Up of Bioprocesses.
  • (source: Nielsen Book Data)9780306473494 20160528
The present text is an extensively revised edition of the textbook first published in 1994. The quantitative treatment of bioprocesses is a central theme in this book. The book has been restructured to make it more easily accessible to the reader, the material has been updated and several new topics have been added in the text. The focus is on the bioreactor and the processes that occur in the reactor, i.e. the coupling between the reactions occurring in the cell and its environment. The microbial cellular metabolism is the starting point in the treatment. Tools for the quantitative analysis of cellular functions - macroscopic mass balancing, thermodynamics of microbial processes, metabolic network analysis and kinetic modelling - are gradually introduced. After analysis of the cellular reactor, the interaction between the cell and its environment is treated in chapters concerning mass transfer and design of bioprocesses. Finally, the complex subject of scale-up is presented.
(source: Nielsen Book Data)9780306473494 20160528
Science Library (Li and Ma)
xl, 604 p. : ill. (some col.) ; 24 cm.
The book presents fundamentals and reviews on the state of the art of mathematical modeling and control of bioprocesses and demonstrates the application on various industrial important biological systems. At the same time, the application of different types of models and control strategies are illustrated as well. The book also takes the recent developments in reactor modeling into account. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.
(source: Nielsen Book Data)9783540669067 20160527
Science Library (Li and Ma)
xiii, 620 p. : ill. ; 24 cm.
  • Design of a bioreactor system - overview. Part 1 Biological systems and media design: organism selection-- bacterial, yeast, and fungal cultures - effect of microorganism type and culture characteristics on bioreactor design and operation-- design, formulation, and optimization of media. Part 2 Bioreactor design: fundamentals of bioreactor design-- stirred tank bioreactors-- pneumatically agitated bioreactors-- membrane reactors-- immobilized microorganism bioreactors-- immobilized animal cell bioreactors-- plant cell bioreactors-- photobioreactors-- bioreactor operation modes-- bioreactor scale-up. Part 3 Bioreactor support systems: sterilization and containment-- bioreactor system supplies.
  • (source: Nielsen Book Data)9780824790028 20160528
Describes the state-of-the-art techniques and methods involved in the design, operation, preparation and containment of bioreactor systems, taking into account the interrelated effects of variables associated with both upstream and downstream stages of the design process. The importance of the initial steps in the development of a bioprocess, such as strain and media selection, that have an overwhelming influence on all further operations, is emphasized. This work is intended for biochemical, chemical and bioprocess engineers; biotechnologists; industrial biochemists; micro- and molecular biologists; food scientists; and upper-level undergraduate and graduate students in these disciplines.
(source: Nielsen Book Data)9780824790028 20160528
Science Library (Li and Ma)
xxiv, 456 p. : ill. ; 26 cm.
Integrating recent research on the physiology and modelling of bioreactions and bioreactors, the authors present a comprehensive, unified introduction to the principles and practices of the field. The work features nearly 100 detailed design examples and problems, many of which are suitable for hands-on demonstrations on a personal computer or for expanded research. The text will serve as a highly instructive guide for students in bioengineering and biotechnology, as well as biochemical, chemical, and environmental engineering.
(source: Nielsen Book Data)9780306446887 20160528
SAL3 (off-campus storage)
x, 345 p. : ill. ; 25 cm.
SAL3 (off-campus storage)
v, 465 p. : ill. ; 24 cm.
Based on a graduate course in biochemical engineering, this title provides the basic knowledge needed for the efficient design of bioreactors and the relevant principles and data for practical process engineering, with an emphasis on enzyme reactors and aerated reactors for microorganisms. It includes exercises.
(source: Nielsen Book Data)9780824784461 20160528
Science Library (Li and Ma)
1 online resource (603 pages) : illustrations (some color)
  • New bioreactor design challenges: An Overview Bioreactors for expansion of induced pluripotent stem cells and their differentiation to cardiac cells Scale up of stem cell manufacture for cell therapy needs Culturing entrapped hESC in continuous stirred reactors Artificial liver bioreactor design Design of microbioreactor system for process development, Multivariate modeling for bioreactor monitoring and control Rational integration of bioreactors with primary recovery Virtual operator training simulators for bioreactors Soft sensor monitoring and control of bioreactors Coping with physiological stress in recombinant protein production by bioreactor design The design bottlenecks with single use bioreactors The Bioreactor-on a-Chip Multibioreactors and Design-of-Experiments Culture media design Systems biotechnology.
  • (source: Nielsen Book Data)9783527683376 20170502
In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.
(source: Nielsen Book Data)9783527683376 20170502
ix, 137 p. : ill. ; 25 cm.
Science Library (Li and Ma)
1 online resource (326 pages) : illustrations, tables
  • 1 INTRODUCTION 1 2 MODES OF OPERATION 3 2.1 Batch Bioreactors 3 2.2 Continuous Bioreactors 9 2.3 Summary 15 3 GAS-LIQUID MASS TRANSFER MODELS 17 4 EXPERIMENTAL MEASUREMENT TECHNIQUES 28 4.1 Measuring Bioreactor Hydrodynamic Characteristics 28 4.1.1 Flow regime measurements 29 4.1.2 Local pressure drop 30 4.1.3 Mixing or residence time 32 4.1.4 Axial diffusion coefficient 33 4.1.5 Gas-liquid interfacial area 34 4.1.6 Bubble size and velocity 35 4.1.7 Global and local liquid velocity 37 4.1.8 Gas holdup 40 Bed expansion 41 Pressure drop measurements 41 Dynamic gas disengagement (DGD) 46 Tomographic techniques 47 4.1.9 Liquid holdup 50 4.1.10 Power measurements 51 4.2 Gas-Liquid Mass Transfer 53 4.2.1 Dissolved oxygen measurement techniques 54 Chemical method 54 Volumetric method 56 Tubing method 56 Optode method 57 Electrochemical electrode method 58 Polarographic electrodes 59 Galvanic probes 61 Electrochemical electrode time constant 61 Electrochemical electrode response time ( e)64 Electrochemical electrode response models 66 Summary of electrochemical electrode response models72 4.2.2 Dissolved carbon monoxide measurements 72 Bioassay overview 74 Needed materials 75 Liquid sample collection 76 Identifying the concentrated myoglobin solutionconcentration 77 Sample preparation for analysis 78 Determining the dissolved CO concentration 79 4.2.3 Determining volumetric gas-liquid mass transfercoefficient, kLa 80 Gas balance method 81 Dynamic method 82 Biological dynamic method 82 Non-biological dynamic method 85 Variations of the inlet step change 86 Dynamic method drawbacks 91 Chemical sorption methods 92 Sulfite oxidation method 92 The hydrazine method 94 Peroxide method 95 Carbon dioxide absorption method 95 4.3 Summary 95 5 MODELING BIOREACTORS 97 5.1 Multiphase Flow CFD Modeling 97 5.1.1 Governing equations for gas-liquid flows 100 5.1.2 Turbulence modeling 101 5.1.3 Interfacial momentum exchange 104 5.1.4 Bubble pressure model 105 5.1.5 Bubble-induced turbulence 106 5.1.6 Modeling bubble size distribution 107 5.2 Biological Process Modeling 109 5.2.1 Simple bioprocess models 111 5.3 Summary 113 6 STIRRED TANK BIOREACTORS 114 6.1 Introduction 114 6.2 Stirred Tank Reactor Flow Regimes 116 6.2.1 Radial Flow Impellers 117 6.2.2 Axial Flow Impellers 122 6.3 Effects of Impeller Design and Arrangement 127 6.3.1 Radial Flow Impellers 129 6.3.2 Axial flow impellers 134 6.3.3 Multiple Impeller Systems 139 6.3.4 Surface Aeration 148 6.3.5 Self-Inducing Impellers 150 6.4 Superficial Gas Velocity 152 6.5 Power Input 155 6.6 Baffle Design 158 6.7 Sparger Design 161 6.7.1 Axial Flow Impellers 162 6.7.2 Radial Flow Impellers 164 6.8 Microbial Cultures 165 6.9 Correlation Forms 172 6.10 Summary 184 7 BUBBLE COLUMN BIOREACTORS 191 7.1 Introduction 191 7.2 Flow Regimes 194 7.3 Column Geometry 202 7.3.1 Column Diameter 202 7.3.2 Unaerated Liquid Height 205 7.3.3 Aspect Ratio 206 7.4 Other Operating Conditions 207 7.4.1 Pressure 207 7.4.2 Temperature 210 7.4.3 Viscosity 212 7.4.4 Surface Tension and Additives 213 7.5 Gas Distributor Design 215 7.6 Correlations 221 7.7 Needed Bubble Column Research 226 7.8 Summary 227 8 AIRLIFT BIOREACTORS 243 8.1 Introduction 243 8.2 Circulation Regimes 247 8.3 Configuration 253 8.3.1 Bioreactor Height 255 8.3.2 Area Ratio 258 8.3.3 Gas Separator 261 8.3.4 Internal-Loop Airlift Bioreactor 266 8.3.5 External-Loop Airlift Bioreactor 268 8.4 Sparger Design 272 8.5 Correlations 277 8.6 Needed Research 280 8.7 Summary 284 9 FIXED BED BIOREACTORS 295 9.1 Introduction 295 9.2 Column Geometry and Components 299 9.3 Flow Regime 307 9.4 Liquid Properties 314 9.5 Packing Material 316 9.5.1 Random Packing 319 9.5.2 Structured Packing 321 9.6 Biological Considerations 324 9.7 Correlations 325 9.8 Needed Research 327 9.9 Summary 328 10 NOVEL BIOREACTORS 333 10.1 Introduction 333 10.2 Novel Bubble-Induced Flow Designs 333 10.3 Miniaturized Bioreactors 341 10.3.1 Microreactors 343 10.3.2 Nanoreactors 348 10.4 Membrane Reactor 349 10.5 Summary 353 11 FIGURES OF MERIT 355 12 CONCLUDING REMARKS 363 13 NOMENCLATURE 367 Abbreviations 375 Greek Symbols 377 Dimensionless numbers 379 14 BIBLIOGRAPHY 382.
  • (source: Nielsen Book Data)9781118104019 20160616
This book reviews and compares the major types of bioreactors used to produce renewable fuels, chemicals, medicines, and proteins, by providing an overview of the hydrodynamics and gas-liquid mass transfer operations in this equipment. These operations are important because they influence the quality and quantity of the desired material produced in the reactor. The text also discusses advantages and disadvantages of each bioreactor and provides a procedure for optimal bioreactor selection based on current process needs, giving chemical and mechanical engineers a practical, working reference.
(source: Nielsen Book Data)9781118104019 20160616
xix, 491 p. : ill.
  • A. Dedication
  • B. Preface
  • C. Acknowledgements
  • D. Author's profile
  • 1. Introduction
  • Overview of biological reactions
  • Elements in bioreactor design
  • Rate expression in biological systems
  • Basic concept of energy transfer
  • Basic concept of mass balance
  • Exercises
  • References
  • Appendix 1
  • References to appendix 1
  • 2. Understanding of bioreactors
  • What is a bioreactor?
  • Why should we study bioreactors?
  • Development of bioreactors
  • Purpose and importance of bioreactors
  • Other bioreactor configurations
  • Bioreactor development for solid-state fermentation (SSF)
  • Classification of bioreactors
  • Bioreactors for animal cell cultivation
  • Bioreactors for plant cell culture
  • Bioreactors for immobilized system
  • Sterilization bioreactors
  • Bioreactors used in different areas of environmental control and management
  • Bioreactors used for combined reactions and separation
  • Exercises
  • References
  • Further reading
  • 3. Bioreactor operation
  • Introduction
  • Common operations of bioreactor
  • Selection/identification of other common factors necessary for smooth operation of bioreactors
  • Spectrum of basic bioreactor operations
  • Reactor operation for immobilized systems
  • Operation of animal cell bioreactors
  • Operation of bioreactors for plant cell culture
  • Reactors for waste management
  • Exercises
  • References
  • Appendix 3
  • 4. Biochemical aspect of bioreactor design
  • Introduction
  • Organization of this chapter
  • Introduction to section a: part 1
  • Introduction to section a: part 2
  • Plug flow tubular reactor (PFTR)
  • Recycle bioreactors
  • Combination of bioreactors
  • Semi-continuous bioreactors
  • Introduction to section B
  • Input to kinetic modeling of enzyme reactors
  • Example problems
  • Exercises
  • References
  • 5. Analysis of non-ideal behavior in bioreactors
  • Introduction
  • Non-ideal parameters
  • Residence time distribution—some aspects of macro mixing
  • Some exercise for RTD of ideal systems (ideal bioreactors)
  • Moments of the distribution
  • E(t) or f(t) and the bioreactor design
  • Models for non-ideal flow
  • Multi parameter models
  • Application of RTD based models to non-ideal bioreactors
  • Drawbacks of classical RTD measurements
  • Transient behavior in bioreactors
  • Stability analysis for continuous flow bioreactor with substrate inhibition
  • Phase plane analysis
  • The bifurcation analysis
  • Exercises
  • References.
  • 6. Bioreactor modeling
  • Model—what is it?
  • Definition of lumped and distributed parameter models
  • Introduction to a few terminologies and theorems
  • Modeling principles
  • Steps in modeling
  • Fundamental laws used in process modeling
  • First–order systems
  • Second-order systems
  • Complexity of the model
  • Parameter sensitivity
  • Exercises
  • References
  • Appendix 6
  • 7. Transport processes in bioreactors
  • Introduction
  • Heat transfer
  • Other parameters influencing transfer operations
  • Exercises
  • References
  • 8. Controls in bioreactors
  • Introduction
  • Control tasks in a bioreactor system
  • Instrumentation to control a bioreactor
  • Controlled variables and measurement devices
  • Procedure for design of efficient control systems
  • Conventional control techniques
  • Advanced control techniques
  • Consistency checks on measurements
  • Adaptive online optimizing control of bioreactor system
  • Exercises
  • References
  • Appendix 8
  • 9. Case studies
  • Introduction
  • Design of packed bed bioreactor
  • Airlift bioreactors
  • Hollow fiber bioreactor (HFBR)
  • Plant cell bioreactor
  • Design of bioreactors for solid state fermentation (SSF)
  • Mammalian cell bioreactor design
  • Exercises
  • References
  • Appendix 9
  • 10. Application of computational fluid dynamics in bioreactor analysis and design
  • Introduction
  • Fluid dynamic modeling
  • Simulation
  • Exercises
  • References
  • Appendix 10
  • 11. Scale-up of bioreactors
  • Introduction
  • Additional scale-up problems in bioreactors
  • Criteria of scale-up
  • Similarity criteria
  • Scale-up methods
  • Generalized approaches to scale-up in combination of methods
  • Examples
  • Exercises
  • References
  • 12. Mechanical aspects of bioreactor design
  • Introduction
  • Requirements for construction of a bioreactor
  • Guidelines for bioreactor design
  • Bioreactor vessels
  • Agitator assembly
  • Exercises
  • References
  • Appendix 12.
computer files (383 pages : illustrations ; 25 cm)
Medical Library (Lane)
1 online resource (496 pages).
Biotechnology has been labelled as one of the key technologies of the last two decades of the 20th Century, offering boundless solutions to problems ranging from food and agricultural production to pharmaceutical and medical applications, as well as environmental and bioremediation problems. Biological processes, however, are complex and the prevailing mechanisms are either unknown or poorly understood. This means that adequate techniques for data acquisition and analysis, leading to appropriate modeling and simulation packages that can be superimposed on the engineering principles, need to be routine tools for future biotechnologists. The present volume presents a masterly summary of the most recent work in the field, covering: instrumentation systems; enzyme technology; environmental biotechnology; food applications; and metabolic engineering.
383 p. : ill. ; 25 cm.
SAL3 (off-campus storage)
p. 50-65 : ill.
Green Library
467 p. : ill. ; 21 cm.
SAL3 (off-campus storage)
1 online resource (357 pages).

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