Book
1 online resource.
"Bioprocess Engineering" involves the design and development of equipment and processes for the manufacturing of products such as food, feed, pharmaceuticals, nutraceuticals, chemicals, and polymers and paper from biological materials. It also deals with studying various biotechnological processes. "Bioprocess Kinetics and Systems Engineering" first of its kind contains systematic and comprehensive content on bioprocess kinetics, bioprocess systems, sustainability and reaction engineering. Dr. Shijie Liu reviews the relevant fundamentals of chemical kinetics-including batch and continuous reactors, biochemistry, microbiology, molecular biology, reaction engineering, and bioprocess systems engineering - introducing key principles that enable bioprocess engineers to engage in the analysis, optimization, design and consistent control over biological and chemical transformations. The quantitative treatment of bioprocesses is the central theme of this book, while more advanced techniques and applications are covered with some depth. Many theoretical derivations and simplifications are used to demonstrate how empirical kinetic models are applicable to complicated bioprocess systems. This title contains extensive illustrative drawings which make the understanding of the subject easy. It also contains worked examples of the various process parameters, their significance and their specific practical use. It provides the theory of bioprocess kinetics from simple concepts to complex metabolic pathways. It incorporates sustainability concepts into the various bioprocesses.
(source: Nielsen Book Data)9780444595256 20160609
Book
xxvii, 740 pages : illustrations (some color) ; 26 cm
  • ENGINEERING FUNDAMENTALS OF BIOPROCESSING Frontiers of Bioprocessing Defining Bioprocessing Current and Emerging Trends in Bioprocess Engineering Materials Advances Nanoscale Advances Bioprocessing for Chemical and Biologic Product Manufacturing Bioprocessing Leaders Worldwide Economic Predictions and Careers in Bioprocess Engineering Skills Needed for Future Bioprocess Engineers Appendix A: A Time Line of Biotechnology Development Introduction to Molecular Biology Introduction Building Blocks of Life: DNA, RNA, and Proteins DNA Replication Transcription Translation Genes Mutations Chromosome DNA Cloning Introduction to Biochemistry Introduction DNA Structure RNA Structure Protein Structure and Function Carbohydrates Lipids, Fats, and Steroids Basic Metabolic Pathways Introduction to Cellular Microbiology Introduction General Cell Structure Eukaryotes, Prokaryotes, Archaea, and Viruses Intracellular Organelles Cellular Transport Intracellular Signal Transduction Reaction Stoichiometry, Thermodynamics, and Kinetics Introduction Mass and Energy Balances Fundamentals of Chemical Reactions Basic Mass Transfer: Diffusion and Convection Basic Fluid Dynamics Basic Thermodynamics Basic Reaction Kinetics Kinetics of Enzymes and Cell Growth Introduction Basic Michaelis-Menten Kinetics Michaelis-Menten Kinetics with Inhibition pH and Transport Limitations Other Enzyme Kinetics Prokaryotic and Eukaryotic Growth Models Advanced Prokaryotic and Eukaryotic Growth Models Data Management Introduction Good Laboratory Practices Electronic Data Handling Data Errors Statistical Analysis Data Conclusions Flow Diagrams Exercises and Solutions HANDBOOK OF BIOPROCESSING Elements of Bioprocessing Introduction Upstream Processing Bioreactor Downstream Processing Genetically Modified Organisms Introduction Cell Line Characterization Characterization of Cell and Virus Banks Cell Line Construction Designing GMCS Vector Host Systems Expression System in E Coli Configuration of Efficient Expression Vectors Protein Production Genetic Manipulations to Improve Yield Manufacturing Overview Introduction Cell Culture Expression Systems Transgenic Animals Cell Lines and Characterization Media Culture Growth Extraction, Isolation, and Purification Capture Purification Impurity Removal Validation Intermediate Purification Polishing Formulation Process Overview Tech Transfer and Documentation Validation Scale Up Specific Economy Issues Process Materials Environment Control Good Manufacturing Controls of Active Pharmaceutical Ingredients Manufacturing Systems and Layout Cleaning Procedures Processing and Filling Laboratory Testing Laboratory Controls Documentation Technical Package Outsourcing in Biotech Manufacturing Issues to Discuss Disposable Bioprocessing Systems Introduction Safety of Disposable Systems Regulatory Matters Risk Assessment Disposable Containers Tank Liners Mixing Systems Disposable Bioreactors Disposable Connectors and Transfers Disposable Control and Monitoring Systems Downstream Processing Filtration Upstream Processing Introduction Bioreactors Batch Culture Continuous Culture Fed-Batch Culture Perfusion Culture Suspension Culture Microcarrier Support Roller Bottle Culture System Spinner Flask Culture Other Scale up Options Wave Bioreactor Cell Cube Technology Rotary Culture System Media Scaling and Production Costs Problem Resolution in Fusion Protein Expression Downstream Processing Introduction Capture System Suitability Downstream Processing Systems Process Flow Purification Introduction Protein Properties Affinity Chromatography Immobilized Metal Affinity Chromatography Anion Exchange Chromatography Cation Exchange Chromatography Size Exclusion Chromatography Reversed Phase Chromatography Hydroxyapatite Chromatography Hydrophobic Interaction Chromatography Scale-up and Optimization Manufacturing Systems Bacterial Expression Systems Genetically Modified Bacteria Mammalian Cells Manufacturing Systems Yeast Cell Expression System Insect Cells Systems Quality Consideration Introduction Management Responsibilities Resources Manufacturing Operations Evaluation Activities Conclusion QA Systems Validation Master Plan Raw Materials Column Life Process Virus Validation Testing of Product In-Process Control Regulatory Affairs Regulatory Issues Protein Degradation Stability Considerations Intellectual Property Introduction Patenting Systems and Strategies The Patent Laws Types of Patent Laws Anatomy of a Patent Patentability Patentability and Technical Information Search Components of a Patent Application Inventions of Interest to Pharmaceutical Scientists Biotechnology Inventions Patenting Strategies Bibliography.
  • (source: Nielsen Book Data)9781466585737 20160619
Biological drug and vaccine manufacturing has quickly become one of the highest-value fields of bioprocess engineering, and many bioprocess engineers are now finding job opportunities that have traditionally gone to chemical engineers. Fundamentals of Modern Bioprocessing addresses this growing demand. Written by experts well-established in the field, this book connects the principles and applications of bioprocessing engineering to healthcare product manufacturing and expands on areas of opportunity for qualified bioprocess engineers and students. The book is divided into two sections: the first half centers on the engineering fundamentals of bioprocessing; while the second half serves as a handbook offering advice and practical applications. Focused on the fundamental principles at the core of this discipline, this work outlines every facet of design, component selection, and regulatory concerns. It discusses the purpose of bioprocessing (to produce products suitable for human use), describes the manufacturing technologies related to bioprocessing, and explores the rapid expansion of bioprocess engineering applications relevant to health care product manufacturing. It also considers the future of bioprocessing-the use of disposable components (which is the fastest growing area in the field of bioprocessing) to replace traditional stainless steel. In addition, this text: * Discusses the many types of genetically modified organisms * Outlines laboratory techniques * Includes the most recent developments * Serves as a reference and contains an extensive bibliography * Emphasizes biological manufacturing using recombinant processing, which begins with creating a genetically modified organism using recombinant techniques Fundamentals of Modern Bioprocessing outlines both the principles and applications of bioprocessing engineering related to healthcare product manufacturing. It lays out the basic concepts, definitions, methods and applications of bioprocessing. A single volume comprehensive reference developed to meet the needs of students with a bioprocessing background; it can also be used as a source for professionals in the field.
(source: Nielsen Book Data)9781466585737 20160619
Biology Library (Falconer)
Book
ii, 542 p. : ill. ; 28 cm.
  • Preface to the Second Edition. Preface to the First Edition. I. INTRODUCTION. 1. What is a Bioprocess Engineer? Introductory Remarks. Biotechnology and Bioprocess Engineering. Biologists and Engineers Differ in Their Approach to Research. The Story of Penicillin: How Biologists and Engineers Work Together. Bioprocesses: Regulatory Constraints. Suggestions for Further Reading. Problems. II. THE BASICS OF BIOLOGY: AN ENGINEER'S PERSPECTIVE. 2. An Overview of Biological Basics. Are All Cells the Same? Cell Construction. Cell Nutrients. Summary. Suggestions for Further Reading. Problems. 3. Enzymes. Introduction. How Enzymes Work. Enzyme Kinetics. Immobilized Enzyme Systems. Large-scale Production of Enzymes. Medical and Industrial Utilization of Enzymes. Summary. Suggestions for Further Reading. Problems. 4. How Cells Work. Introduction. The Central Dogma. DNA Replication: Preserving and Propagating the Cellular Message. Transcription: Sending the Message. Translation: Message to Product. Metabolic Regulation. How the Cell Senses Its Extracellular Environment. Summary. Appendix: Examples of Regulation of Complex Pathways. Suggestions for Further Reading. Problems. 5. Major Metabolic Pathways. Introduction. Bioenergetics. Glucose Metabolism: Glycolysis and the TCA Cycle. Respiration. Control Sites in Aerobic Glucose Metabolism. Metabolism of Nitrogenous Compounds. Nitrogen Fixation. Metabolism of Hydrocarbons. Overview of Biosynthesis. Overview of Anaerobic Metabolism. Overview of Autotrophic Metabolism. Summary. Suggestions for Further Reading. Problems. 6. How Cells Grow. Introduction. Batch Growth. Quantifying Growth Kinetics. How Cells Grow in Continuous Culture. Summary. Suggestions for Further Reading. Problems. 7. Stoichiometry of Microbial Growth and Product Formation. Introduction. Some Other Definitions. Stoichiometric Calculations. Theoretical Predictions of Yield Coefficients. Summary. Suggestions for Further Reading. Problems. 8. How Cellular Information is Altered. Introduction. Evolving Desirable Biochemical Activities through Mutation and Selection. Natural Mechanisms for Gene Transfer and Rearrangement. Genetically Engineering Cells. Genomics. Summary. Suggestions for Further Reading. Problems. III. ENGINEERING PRINCIPLES FOR BIOPROCESSES. 9. Operating Considerations for Bioreactors for Suspension and Immobilized Cultures. Introduction. Choosing the Cultivation Method. Modifying Batch and Continuous Reactors. Immobolized Cell Systems. Solid-state Fermentations. Summary. Suggestions for Further Reading. Problems. 10. Selection, Scale-Up, Operation, and Control of Bioreactors. Introduction. Scale-up and Its Difficulties. Bioreactor Instrumentation and Control. Sterilization of Process Fluids. Summary. Suggestions for Further Reading. Problems. 11. Recovery and Purification of Products. Strategies to Recover and Purify Products. Separation of Insoluble Products. Cell Disruption. Separation of Soluble Products. Finishing Steps for Purification. Integration of Reaction and Separation. Summary. Suggestions for Further Reading. Problems. IV. APPLICATIONS TO NONCONVENTIONAL BIOLOGICAL SYSTEMS. 12. Bioprocess Considerations in Using Animal Cell Cultures. Structure and Biochemistry of Animal Cells. Methods Used for the Cultivation of Animal Cells. Bioreactor Considerations for Animal Cell Culture. Products of Animal Cell Cultures. Summary. Suggestions for Further Reading. Problems. 13. Bioprocess Considerations in Using Plant Cell Cultures. Why Plant Cell Cultures? Plant Cells in Culture Compared to Microbes. Bioreactor Considerations. Economics of Plant Cell Tissue Cultures. Summary. Suggestions for Further Reading. Problems. 14. Utilizing Genetically Engineered Organisms. Introduction. How the Product Influences Process Decisions. Guidelines for Choosing Host-Vector Systems. Process Constraints: Genetic Instability. Considerations in Plasmid Design to Avoid Process Problems. Predicting HostDVector Interactions and Genetic Instability. Regulatory Constraints on Genetic Processes. Metabolic Engineering. Protein Engineering. Summary. Suggestions for Further Reading. Problems. 15. Medical Applications of Bioprocess Engineering. Introduction. Tissue Engineering. Gene Therapy Using Viral Vectors. Bioreactors. Summary. Suggestions for Further Reading. Problems. 16. Mixed Cultures. Introduction. Major Classes of Interactions in Mixed Cultures. Simple Models Describing Mixed-culture Interactions. Mixed Cultures in Nature. Industrial Utilization of Mixed Cultures. Biological Waste Treatment: An Example of the Industrial Utilization of Mixed Cultures. Summary. Suggestions for Further Reading. Problems. Appendix: Traditional Industrial Bioprocesses. Anaerobic Bioprocesses. Aerobic Processes. Index.
  • (source: Nielsen Book Data)9781292025995 20160612
For Senior-level and graduate courses in Biochemical Engineering, and for programs in Agricultural and Biological Engineering or Bioengineering. This concise yet comprehensive text introduces the essential concepts of bioprocessing-internal structure and functions of different types of microorganisms, major metabolic pathways, enzymes, microbial genetics, kinetics and stoichiometry of growth and product information-to traditional chemical engineers and those in related disciplines. It explores the engineering principles necessary for bioprocess synthesis and design, and illustrates the application of these principles to modern biotechnology for production of pharmaceuticals and biologics, solution of environmental problems, production of commodities, and medical applications.
(source: Nielsen Book Data)9781292025995 20160612
Chemistry & ChemEng Library (Swain)
Book
xix, 245 p. : ill. ; 24 cm
  • Historical development: From ethanol to biopharmeceuticals-- Microbiology-- Metabolic macromolecules-- Molecular biology-- Carbon metabolism-- Enzymes as biocatalysts-- Microbial kinetics during batch, continuous and fed-batch processes-- The oxygen transfer rate and overall volumetric oxygen transfer coefficient-- Bioprocess scale up-- Bioprocess asepsis and sterility-- Downstream processing.
  • (source: Nielsen Book Data)9781782421672 20160612
Biotechnology is an expansive field incorporating expertise in both the life science and engineering disciplines. In biotechnology, the scientist is concerned with developing the most favourable biocatalysts, while the engineer is directed towards process performance, defining conditions and strategies that will maximize the production potential of the biocatalyst. Increasingly, the synergistic effect of the contributions of engineering and life sciences is recognised as key to the translation of new bioproducts from the laboratory bench to commercial bioprocess. Fundamental to the successful realization of the bioprocess is a need for process engineers and life scientists competent in evaluating biological systems from a cross-disciplinary viewpoint. Bioprocess engineering aims to generate core competencies through an understanding of the complementary biotechnology disciplines and their interdependence, and an appreciation of the challenges associated with the application of engineering principles in a life science context. Initial chapters focus on the microbiology, biochemistry and molecular biology that underpin biocatalyst potential for product accumulation. The following chapters develop kinetic and mass transfer principles that quantify optimum process performance and scale up. The text is wide in scope, relating to bioprocesses using bacterial, fungal and enzymic biocatalysts, batch, fed-batch and continuous strategies and free and immobilised configurations. * Details the application of chemical engineering principles for the development, design, operation and scale up of bioprocesses* Details the knowledge in microbiology, biochemistry and molecular biology relevant to bioprocess design, operation and scale up* Discusses the significance of these life sciences in defining optimum bioprocess performance.
(source: Nielsen Book Data)9781782421672 20160612
Biology Library (Falconer)
Book
1 online resource (viii, 919 p.) : ill.
  • Introduction
  • Material and energy balances
  • Physical processes
  • Reactions and reactors.
This welcome new edition discusses bioprocess engineering from the perspective of biology students. It includes a great deal of new material and has been extensively revised and expanded. These updates strengthen the book and maintain its position as the book of choice for senior undergraduates and graduates seeking to move from biochemistry/microbiology/molecular biology to bioprocess engineering. New to this edition: * All chapters thoroughly revised for current developments, with over 200 pgs of new material, including significant new content in: * Metabolic Engineering * Sustainable Bioprocessing * Membrane Filtration * Turbulence and Impeller Design * Downstream Processing * Oxygen Transfer Systems * Over 150 new problems and worked examples * More than 100 new illustrations.
(source: Nielsen Book Data)9780122208515 20160609
Book
xiv, 360 p. : ill. (some col.).
Book
xv, 292 p. : ill. ; 24 cm.
  • Enzyme Kinetics-- Immobilized Enzyme-- Industrial Applications of Enzymes-- Cell Cultivations-- Cell Kinetics and Fermenter Design-- Genetic Engineering-- Sterilization-- Agitation and Aeration-- Downstream Processing.
  • (source: Nielsen Book Data)9783540779001 20160605
The biology, biotechnology, chemistry, pharmacy and chemical engineering students at various universtiy and engineering institutions are required to take the Biochemical Engineering course either as an elective or compulsory subject. This book is written keeping in mind the need for a text book on afore subject for students from both engineering and biology backgrounds. The main feature of this book is that it contains the solved problems, which help the students to understand the subject better. The book is divided into three sections: Enzyme mediated bioprocess, whole cell mediated bioprocess and the engineering principle in bioprocess. Dr. Rajiv Dutta is Professor in Biotechnology and Director, Amity Institute of Biotechnology, Lucknow. He earned his M. Tech. in Biotechnology and Engineering from the Department of Chemical Engineering, IIT, Kharagpur and Ph.D. in Bioelectronics from BITS, Pilani. He has taught Biochemical Engineering and Biophysics to B.E., M.E. and M.Sc. level student carried out advanced research in the area of Ion channels at the Department of Botany at Oklahoma State University, Stillwater and Department of Biological Sciences at Purdue University, West Lafayette, IN. He also holds the position of Nanion Technologies Adjunct Research Professor at Research Triangle Institute, RTP, NC. He had received various awards including JCI Outstanding Young Person of India and ISBEM Dr. Ramesh Gulrajani Memorial Award 2006 for outstanding research in electro physiology.
(source: Nielsen Book Data)9783540779001 20160605
dx.doi.org SpringerLink
Book
xv, 292 p. : ill. ; 24 cm.
  • Enzyme Kinetics-- Immobilized Enzyme-- Industrial Applications of Enzymes-- Cell Cultivations-- Cell Kinetics and Fermenter Design-- Genetic Engineering-- Sterilization-- Agitation and Aeration-- Downstream Processing.
  • (source: Nielsen Book Data)9783540779001 20160605
The biology, biotechnology, chemistry, pharmacy and chemical engineering students at various universtiy and engineering institutions are required to take the Biochemical Engineering course either as an elective or compulsory subject. This book is written keeping in mind the need for a text book on afore subject for students from both engineering and biology backgrounds. The main feature of this book is that it contains the solved problems, which help the students to understand the subject better. The book is divided into three sections: Enzyme mediated bioprocess, whole cell mediated bioprocess and the engineering principle in bioprocess. Dr. Rajiv Dutta is Professor in Biotechnology and Director, Amity Institute of Biotechnology, Lucknow. He earned his M. Tech. in Biotechnology and Engineering from the Department of Chemical Engineering, IIT, Kharagpur and Ph.D. in Bioelectronics from BITS, Pilani. He has taught Biochemical Engineering and Biophysics to B.E., M.E. and M.Sc. level student carried out advanced research in the area of Ion channels at the Department of Botany at Oklahoma State University, Stillwater and Department of Biological Sciences at Purdue University, West Lafayette, IN. He also holds the position of Nanion Technologies Adjunct Research Professor at Research Triangle Institute, RTP, NC. He had received various awards including JCI Outstanding Young Person of India and ISBEM Dr. Ramesh Gulrajani Memorial Award 2006 for outstanding research in electro physiology.
(source: Nielsen Book Data)9783540779001 20160605
Book
p. 11928-12084.
SAL3 (off-campus storage)
Book
191 p. : ill.
  • Editorial: S.-O. Enfors, L. van der Wielen, U. von Stockar: Process Integration Challenges in Biotechnology Yesterday, Today and Tomorrow.- U. von Stockar, L. van der Wielen: Back to Basics: Thermodynamics in Biochemical Engineering.- S. Schmalzriedt, M. Jenne, K. Mauch, M. Reuss: Integration of Physiology and Fluiddynamics.- A. Bruggink, L. van der Wielen: A Fine Chemical Industry for Life Science Products: Green Solution to Chemical Challenges.- P. Fernandes, D.M.F. Prazeres, J.M.S. Cabral: Membrane-Assisted Extractive Bioconversion.- D. Stark, U. von Stockar: In-situ Product Removal in Whole Cell Biotechnolgy During the Last 20 Years.
  • (source: Nielsen Book Data)9783540436300 20160528
Process integration has been one of the most active research fields in Biochemical Engineering over the last decade and it will continue to be so if bioprocessing is to become more rational, efficient and productive. This volume outlines what has been achieved in recent years. Written by experts who have made important contributions to the European Science, Foundation Program on Process Integration in Biochemical Engineering, the volume focuses on the progress made and the major opportunities, and in addition on the limitations and the challenges in bioprocess integration that lie ahead. The concept of bioprocess integration is treated at various levels, including integration at the molecular, biological, bioreactor and plant levels, but also accounting for the integration of separation and mass transfer operations and biology, fluid dynamics and physiology, as well as basic science and process technology.
(source: Nielsen Book Data)9783540436300 20160528
SAL3 (off-campus storage)
Book
xx, 553 p. : ill. ; 24 cm.
  • Preface to the Second Edition. Preface to the First Edition. I. INTRODUCTION. 1. What is a Bioprocess Engineer? Introductory Remarks. Biotechnology and Bioprocess Engineering. Biologists and Engineers Differ in Their Approach to Research. The Story of Penicillin: How Biologists and Engineers Work Together. Bioprocesses: Regulatory Constraints. Suggestions for Further Reading. Problems. II. THE BASICS OF BIOLOGY: AN ENGINEER'S PERSPECTIVE. 2. An Overview of Biological Basics. Are All Cells the Same? Cell Construction. Cell Nutrients. Summary. Suggestions for Further Reading. Problems. 3. Enzymes. Introduction. How Enzymes Work. Enzyme Kinetics. Immobilized Enzyme Systems. Large-scale Production of Enzymes. Medical and Industrial Utilization of Enzymes. Summary. Suggestions for Further Reading. Problems. 4. How Cells Work. Introduction. The Central Dogma. DNA Replication: Preserving and Propagating the Cellular Message. Transcription: Sending the Message. Translation: Message to Product. Metabolic Regulation. How the Cell Senses Its Extracellular Environment. Summary. Appendix: Examples of Regulation of Complex Pathways. Suggestions for Further Reading. Problems. 5. Major Metabolic Pathways. Introduction. Bioenergetics. Glucose Metabolism: Glycolysis and the TCA Cycle. Respiration. Control Sites in Aerobic Glucose Metabolism. Metabolism of Nitrogenous Compounds. Nitrogen Fixation. Metabolism of Hydrocarbons. Overview of Biosynthesis. Overview of Anaerobic Metabolism. Overview of Autotrophic Metabolism. Summary. Suggestions for Further Reading. Problems. 6. How Cells Grow. Introduction. Batch Growth. Quantifying Growth Kinetics. How Cells Grow in Continuous Culture. Summary. Suggestions for Further Reading. Problems. 7. Stoichiometry of Microbial Growth and Product Formation. Introduction. Some Other Definitions. Stoichiometric Calculations. Theoretical Predictions of Yield Coefficients. Summary. Suggestions for Further Reading. Problems. 8. How Cellular Information is Altered. Introduction. Evolving Desirable Biochemical Activities through Mutation and Selection. Natural Mechanisms for Gene Transfer and Rearrangement. Genetically Engineering Cells. Genomics. Summary. Suggestions for Further Reading. Problems. III. ENGINEERING PRINCIPLES FOR BIOPROCESSES. 9. Operating Considerations for Bioreactors for Suspension and Immobilized Cultures. Introduction. Choosing the Cultivation Method. Modifying Batch and Continuous Reactors. Immobolized Cell Systems. Solid-state Fermentations. Summary. Suggestions for Further Reading. Problems. 10. Selection, Scale-Up, Operation, and Control of Bioreactors. Introduction. Scale-up and Its Difficulties. Bioreactor Instrumentation and Control. Sterilization of Process Fluids. Summary. Suggestions for Further Reading. Problems. 11. Recovery and Purification of Products. Strategies to Recover and Purify Products. Separation of Insoluble Products. Cell Disruption. Separation of Soluble Products. Finishing Steps for Purification. Integration of Reaction and Separation. Summary. Suggestions for Further Reading. Problems. IV. APPLICATIONS TO NONCONVENTIONAL BIOLOGICAL SYSTEMS. 12. Bioprocess Considerations in Using Animal Cell Cultures. Structure and Biochemistry of Animal Cells. Methods Used for the Cultivation of Animal Cells. Bioreactor Considerations for Animal Cell Culture. Products of Animal Cell Cultures. Summary. Suggestions for Further Reading. Problems. 13. Bioprocess Considerations in Using Plant Cell Cultures. Why Plant Cell Cultures? Plant Cells in Culture Compared to Microbes. Bioreactor Considerations. Economics of Plant Cell Tissue Cultures. Summary. Suggestions for Further Reading. Problems. 14. Utilizing Genetically Engineered Organisms. Introduction. How the Product Influences Process Decisions. Guidelines for Choosing Host-Vector Systems. Process Constraints: Genetic Instability. Considerations in Plasmid Design to Avoid Process Problems. Predicting Host--Vector Interactions and Genetic Instability. Regulatory Constraints on Genetic Processes. Metabolic Engineering. Protein Engineering. Summary. Suggestions for Further Reading. Problems. 15. Medical Applications of Bioprocess Engineering. Introduction. Tissue Engineering. Gene Therapy Using Viral Vectors. Bioreactors. Summary. Suggestions for Further Reading. Problems. 16. Mixed Cultures. Introduction. Major Classes of Interactions in Mixed Cultures. Simple Models Describing Mixed-culture Interactions. Mixed Cultures in Nature. Industrial Utilization of Mixed Cultures. Biological Waste Treatment: An Example of the Industrial Utilization of Mixed Cultures. Summary. Suggestions for Further Reading. Problems. 17. Epilogue. Appendix: Traditional Industrial Bioprocesses. Anaerobic Bioprocesses. Aerobic Processes. Suggestions for Further Reading. Index.
  • (source: Nielsen Book Data)9780130819086 20160528
For Senior-level and graduate courses in Biochemical Engineering, and for programs in Agricultural and Biological Engineering or Bioengineering. This concise yet comprehensive text introduces the essential concepts of bioprocessing--internal structure and functions of different types of microorganisms, major metabolic pathways, enzymes, microbial genetics, kinetics and stoichiometry of growth and product information--to traditional chemical engineers and those in related disciplines. It explores the engineering principles necessary for bioprocess synthesis and design, and illustrates the application of these principles to modern biotechnology for production of pharmaceuticals and biologics, solution of environmental problems, production of commodities, and medical applications.
(source: Nielsen Book Data)9780130819086 20160528
Chemistry & ChemEng Library (Swain)
Book
vi, 247 p. : ill. ; 25 cm.
  • J. Mukherjee, M. Menge: Progress and Prospects of Ergot Alkaloid Research * E. Vandamme: Antimicrobial Peptides of Lactic Acid Bacteria * D.A. Mitchel, M. Berovic, N. Krieger: Biochemical Engineering Aspects of Solid State Bioprocessing * K.S.M.S. Raghavarao, M. Dueser, P. Todd: Multistage Magnetic and Electrophoretic Extraction of Cells, Particles and Macromolecules * K. Schugerl: Recovery of Proteins and Micro-Organisms from Cultivation Media by Foam Flotation *.
  • (source: Nielsen Book Data)9783540673620 20160528
This review series covers trends in modern biology. All aspects of this technology including aspects of chemistry, biochemistry, microbiology, genetics and chemical engineering, are treated.
(source: Nielsen Book Data)9783540673620 20160528
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SAL3 (off-campus storage)
Book
xviii, 732 p. : ill. ; 24 cm.
  • Systems Concepts for Transport Processes-- Fluid Flow Systems-- Heat Transfer Systems-- Mass Transfer-- Life Systems-- References-- Index.
  • (source: Nielsen Book Data)9780471245476 20160528
A unique, accessible guide to the application of engineering methods to biological systems. Presenting for the first time a practical, design-oriented, interdisciplinary approach to transport phenomena involving biological systems, Biological Process Engineering emphasizes the common aspects of the three main transport processes-fluid flow, heat transfer, and mass transfer. In clear and simple terms, it explores the relevance of these processes to broadly defined biological systems such as the growth of microbes in bioreactors, the leaching of pollutants into groundwater, and the chemistry of food manufacturing. Reaching well beyond standard applications in medicine and the environment to areas of biotechnology, aquaculture, agriculture, and food processing, this book promotes analogical thinking that will lead to creative solutions. While keeping the mathematics to a minimum, it explains principles of effective system modeling and demonstrates a wide variety of problem-solving techniques. Readers will find: Systems diagrams comparing and contrasting different transport processes Biological examples for all types of systems, including metabolic pathways, locomotion, reproduction, responses to thermal conditions, and more Numerous design charts and procedures An extensive collection of tables of parameter values, not found in any other text. An ideal undergraduate text for biological engineering students taking courses in transport processes, Biological Process Engineering is also an excellent reference for practicing engineers. It introduces the reader to diverse biological phenomena, serves as a stepping-stone to more theoretical topics, and provides important insights into the fast-growing arena of biological engineering.
(source: Nielsen Book Data)9780471245476 20160528
SAL3 (off-campus storage)
Book
702 p.
  • Enzyme catalysis-- immobilized biocatalysis-- microbial growth-- bioreactor design and analysis-- transport processes-- product recovery--.
  • (source: Nielsen Book Data)9780824789497 20160527
This work provides comprehensive coverage of modern biochemical engineering, detailing the basic concepts underlying the behaviour of bioprocesses as well as advances in bioprocess and biochemical engineering science. It includes discussions of topics such as enzyme kinetics and biocatalysis, microbial growth and product formation, bioreactor design, transport in bioreactors, bioproduct recovery and bioprocess economics and design. A solutions manual is available to instructors only.
(source: Nielsen Book Data)9780824789497 20160527
SAL3 (off-campus storage)
Book
x, 193 p. : ill. ; 24 cm.
  • Contents: L. Eggeling, H. Sahm, A.A. de Graaf: Quantifying and Directing Metabolite Flux: Application to Amino Acid Overproduction.- R. Kr?mer: Analysis and Modeling of Substrate Uptake and Product Release by Prokaryotic and Eukaryotic Cells.- D. Weuster-Botz, A.A. de Graaf: Reaction Engineering Methods to Study Intracellular Metabolite Concentrations.- W. Wiechert, A.A. de Graaf: In Vivo Stationary Flux Analysis by 13C Labeling Experiments.- B. Sonnleitner: New Concepts for Quantitative Bioprocess Research and Development.
  • (source: Nielsen Book Data)9783540606697 20160616
This collection of papers on metabolic engineering covers such areas as quantifying and directing metabolic flux, analysis and modelling of substrate uptake and product release by prokaryotic and eukaryotic cells, and in vivo stationary flux analysis.
(source: Nielsen Book Data)9783540606697 20160616
SAL3 (off-campus storage)
Book
x, 321 p. : ill. ; 24 cm.
SAL3 (off-campus storage)
Book
1 v.
Green Library
Book
xxx, 451 p. : ill. ; 24 cm.
SAL3 (off-campus storage)
Book
x, 374 p. : ill. ; 27 cm.
SAL3 (off-campus storage)
Book
x, 304 p. : ill. ; 24 cm.
  • An Overview of Biochemical Engineering-- Microbial Cells and Enzymes-- Analysis of Biological Reactors-- Biomass Refining-- Applied Genetics for Biochemical Engineering: Recombinant DNA-- Molecular Enzyme Engineering-- Applied Genetics and Molecular Biology of Industrial Microorganisms-- Challenges and Opportunities in Product Recovery-- Separation by Sorption-- Membrane Separation Technology: An Overview-- Index.
  • (source: Nielsen Book Data)9780471812791 20160527
This applications approach to the engineering aspects of biological manufacturing, provides practical coverage of fermentation reactor design, purification processes, modern biology, genetic engineering and biological waste treatment. Also included is material on fuels, chemicals from biomass, mass transfer in biological systems, design of novel bioreactors and many other topics. The book was developed from an industrial training course for engineers in industries that manufacture biological products and is presented in a manner that requires only a minimum background in the biological sciences.
(source: Nielsen Book Data)9780471812791 20160527
SAL3 (off-campus storage)

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