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Book
1 online resource.
Antimicrobial textiles have attracted a great deal of interest in recent years due to their potential for reducing the transmission of infection in medical and healthcare environments. Antimicrobial properties can also improve the performance and lifespan of consumer products, and so these fabrics are increasingly finding applications in the wider textile and apparel industry. This book provides systematic coverage of the technologies and materials required for developing these important textiles. In Part One, chapters address key issues and technologies in the creation of antimicrobial textile products. Topics covered include testing and regulation, microencapsulation, sol-gel coating and plasma technologies, nanotechnology and life cycle assessment. Part Two then reviews key antimicrobial agents, such as N-halamines, plant based compounds and photo-active chemicals. Finally, the chapters of Part Three offer detailed reviews of antimicrobial textiles for particular important applications, including medical devices, protective clothing and products with improved durability and longevity.
Book
1 online resource
Biosynthetic Polymers for Medical Applications provides the latest information on biopolymers, the polymers that have been produced from living organisms and are biodegradable in nature. These advanced materials are becoming increasingly important for medical applications due to their favorable properties, such as degradability and biocompatibility. This important book provides readers with a thorough review of the fundamentals of biosynthetic polymers and their applications. Part One covers the fundamentals of biosynthetic polymers for medical applications, while Part Two explores biosynthetic polymer coatings and surface modification. Subsequent sections discuss biosynthetic polymers for tissue engineering applications and how to conduct polymers for medical applications. * Comprehensively covers all major medical applications of biosynthetic polymers* Provides an overview of non-degradable and biodegradable biosynthetic polymers and their medical uses* Presents a specific focus on coatings and surface modifications, biosynthetic hydrogels, particulate systems for gene and drug delivery, and conjugated conducting polymers.
(source: Nielsen Book Data)
Book
1 online resource.
Databook of Nucleating Agents gives engineers and materials scientists the information they need to increase the production rate, modify structure and morphology, and reduce haze of polymeric products with proper selection of nucleating agents and clarifying agents. Chemical origin and related properties of nucleating agents are analyzed in general terms to highlight the differences in their properties, including the essential theoretical knowledge required for correct selection and use of nucleating and clarifying agents. This includes methods of chemical modification of nucleating agents and their deposition on suitable substrates; methods, and results of dispersion of nucleating agents, influence of their concentration and cooling rate on final result and rate of crystallization, nucleation efficiency of different products and the reasons behind it, and generally accepted mechanisms of nucleation. The book also covers application aspects in different formulations. Patent literature and research papers are extensively reviewed for different applications, and polymer processing methods which require use of nucleating agents are discussed, with an emphasis on the intricacies of use of nucleating agents in different polymers and products.
Book
1 online resource (ix, 302 pages) : illustrations (some color).
  • Conformational and dynamic behavior of polymers in solutions.- Self-assembly of amphiphilic copolymers in selective solvents.- Electrostatically driven assembly of polyelectrolytes.- Theoretical principles of fluorescence spectroscopy.- Historical perspective of advances in fluorescence research on polymer systems.- Fluorescence studies of self- and co-assembling polymer systems.- Pyrene-labeled water-soluble macromolecules as fluorescent mimics of associative.- Fluorescence correlation spectroscopy studies of polymer systems.
  • (source: Nielsen Book Data)
This volume describes the application of fluorescence spectroscopy in polymer research. The first chapters outline the basic principles of the conformational and dynamic behavior of polymers and review the problems of polymer self-assembly. Subsequent chapters introduce the theoretical principles of advanced fluorescence methods and typical examples of their application in polymer science. The book closes with several reviews of various fluorescence applications for studying specific aspects of polymer-solution behavior. It is a useful resource for polymer scientists and experts in fluorescence spectroscopy alike, facilitating their communication and cooperation.
(source: Nielsen Book Data)
Book
1 online resource.
Handbook of Nucleating Agents gives engineers and materials scientists the information they need to increase the production rate, modify structure and morphology, and reduce haze of polymeric products with proper selection of nucleating agents and clarifying agents. Chemical origin and related properties of nucleating agents are analyzed in general terms to highlight the differences in their properties, including the essential theoretical knowledge required for correct selection and use of nucleating and clarifying agents. This includes methods of chemical modification of nucleating agents and their deposition on suitable substrates; methods and results of dispersion of nucleating agents; influence of their concentration and cooling rate on final result and rate of crystallization; nucleation efficiency of different products and the reasons behind it; and generally accepted mechanisms of nucleation. The book also covers application aspects in different formulations. Patent literature and research papers are extensively reviewed for different applications, and polymer processing methods which require use of nucleating agents are discussed, with an emphasis on the intricacies of use of nucleating agents in different polymers and products.
Book
1 online resource.
Handbook of Polymers, Second Edition, presents normalized, up-to-date polymer data in a consistent and easily referenceable layout. This new edition represents an update of the available data, including new values for many commercially available products, verification of existing data, and removal of older data where it is no longer useful. The book includes data on all major polymeric materials used by the plastics industry and all branches of the chemical industry, as well as specialty polymers used in the electronics, pharmaceutical, medical, and space fields. The entire scope of the data is divided into sections to make data comparison and search easy, including synthesis, physical, mechanical, and rheological properties, chemical resistance, toxicity and environmental impact, and more. The data enables engineers and materials scientists to solve practical problems, be that in applications, research and development, or legislation. The most current grades of materials have been selected to provide readers with information that is characteristic of currently available products.
Book
1 online resource : illustrations.
  • The Lotus Flower fiber and sustainable luxury.- Flax: Sustainability is the New Luxury.- Great potential of stinging Nettle for sustainable textile and fashion.- Sustainable Luxury Natural Fibers -Production, Properties and Prospects.- Sustainable processing of luxury textiles.- Sustainability in luxury textile applications: a contradiction or a new business opportunity?.- Specialty Chemical Finishes for Sustainable Luxurious Textiles.- Book Chapter for Handbook of Sustainable luxury textiles and Fashion- Vol 1.
  • (source: Nielsen Book Data)
The first volume of this handbook explores different aspects of sustainable luxury textiles and fashion, broadly based on the following topics: Sustainability and business management, Value chain management, Use of materials and Sustainable production processes.
(source: Nielsen Book Data)
Book
1 online resource : illustrations (some color).
The first edition of Handbook of Technical Textiles has been an essential purchase for professionals and researchers in this area since its publication in 2000. With revised and updated coverage, including several new chapters, this revised two volume second edition reviews recent developments and new technologies across the field of technical textiles. Volume 2 - Technical Textile Applications offers an indispensable guide to established and developing areas in the use of technical textiles. The areas covered include textiles for personal protection and welfare, such as those designed for ballistic protection, personal thermal and fire protection, and medical applications; textiles for industrial, transport and engineering applications, including composite reinforcement and filtration; and the growing area of smart textiles.
Book
1 online resource (453 p.).
The first edition of Handbook of Technical Textiles has been an essential purchase for professionals and researchers in this area since its publication in 2000. With revised and updated coverage, including several new chapters, this revised two volume second edition reviews recent developments and new technologies across the field of technical textiles. Volume 2 - Technical Textile Applications offers an indispensable guide to established and developing areas in the use of technical textiles. The areas covered include textiles for personal protection and welfare, such as those designed for ballistic protection, personal thermal and fire protection, and medical applications; textiles for industrial, transport and engineering applications, including composite reinforcement and filtration; and the growing area of smart textiles. * Comprehensive handbook for all aspects of technical textiles* Provides updated, detailed coverage of processes, fabric structure, and applications* Ideal resource for those interested in high-performance textiles, textile processes, textile processing, and textile applications* Many of the original, recognized experts from the first edition update their respective chapters.
(source: Nielsen Book Data)
Book
1 online resource
  • Introduction
  • Models for Polymer Chains
  • Chain Statistics
  • Wormlike Chains
  • Chain Statistics
  • Helical Wormlike Chains
  • Equilibrium Properties
  • Transport Properties
  • Applications to Circular DNA
  • Excluded-Volume Effects
  • Simulation and More on Excluded-Volume Effects
  • Chain Dynamics
  • Dynamical Properties.
This book presents the "helical wormlike chain" model - a general model for both flexible and semiflexible polymer chains. It explains how statistical-mechanical, hydrodynamic, and dynamic theories of their solution properties can be developed on the basis of this model. This new second edition has been carefully updated and thoroughly revised. It includes a new chapter covering "Simulation and More on Excluded-Volume Effects", as well as the discussion of new experimental data and the application of the theory to ring polymers. The authors provide analysis of important recent experimental data by the use of their theories for flexible polymers over a wide range of molecular weights, including the oligomer region, and for semiflexible polymers, including biological macromolecules such as DNA. This is all clearly illustrated using a reasonable number of theoretical equations, tables, figures, and computer-aided forms, which support the understanding of the basic theory and help to facilitate its application to experimental data for the polymer molecular characterization.
Book
1 online resource (xxiii, 434 pages).
  • Fundamentals of Ionic Polymer Metal Composites (IPMCs)-- Ionic Polymer Metal Composites (IPMCs) Optimal Manufacturing-- Graphene-based Ionic Polymer Actuators-- What Happens at the Ionomer-Electrode Interfaces and How it Influences Sensing and Actuation in IPMCs-- Modeling IPMCs with Comsol: Step-by-Step Guide-- Ionic Polymer Metal Composites with Electrochemically Active Electrodes-- Electromechanical Distributed Modeling of IPMCs-- Modeling for Engineering Design of IPMC Devices: from a Continuum Electromechanical Model to its Lumped-Parameter Representation-- Electric Energy Storage using IMPCs: Towards a Flexible IMPC for Low-power Devices-- Modeling of Environment-Dependent IPMC Actuation and Sensing Dynamics-- Precision Feedback and Feedforward Control of Ionic Polymer-Metal Composite Actuators-- Design, Test, and Micromanipulation using an IPMC Microgripper-- Phenomenon of Spatially Growing Wave of a Snake-like Robot: Natural Generation of Biomimetic Swimming Motion-- Energy Exchange betwem Coherent Fluid Structures and IPMC, toward Flow Sensing and Energy Harvesting-- Miniature Pump with IPMC Actuator for Drug Delivery-- Modelling and Characterization of IPMC Transducers: from IPMC Infancy to Multiphysics Modeling-- IPMC as Post-silicon Transducers for the Realization of Smart Systems-- Micromechanined IPMC Actuators for Biomedical Applications-- IPMCs: Recent Advances in Self-sensing Methods-- A Continuum Multiphysics Theory for Electroactive Polymers and IPMCs-- Multiphysics Modeling of Non-Linear IPMC Plates-- Ionic Polymer-Metal Composites (IPMCs) as Dexterous Manipulators and Haptic Feedback/Tactile Sensors for Minimally Invasive Robotic Surgery-- IPMCs as Soft Biomimetic Robotic Artificial Muscles-- Ionic Electroactive Actuators with Giant Electromechanical Response-- Multiphysics Modeling and Simulation of Dynamics Sensing in Ionic Polymer Metal Composites (IPMCs) with Applications to Soft Robotics-- Comprehensive Review on Electroactive Paper Actuators--.
  • (source: Nielsen Book Data)
Ionic polymer metal composites (IPMCs) can generate a voltage when physically deformed. Conversely, an applied small voltage or electrical field can induce an array of spectacular large deformation or actuation behaviours in IPMCs, such as bending, twisting, rolling, twirling, steering and undulating. An important smart material, IPMCs have applications in energy harvesting and as self-powered strain or deformation sensors, they are especially suitable for monitoring the shape of dynamic structures. Other uses include soft actuation applications and as a material for biomimetic robotic soft artificial muscles in industrial and medical contexts. This comprehensive volume on ionic polymer metal composites provides a broad coverage of the state of the art and recent advances in the field written by some of the world's leading experts on various characterizations and modeling of IPMCs. Topics covered in this two volume set include uses in electrochemically active electrodes, electric energy storage devices, soft biomimetic robotics artificial muscles, multiphysics modeling of IPMCs, biomedical applications, IPMCs as dexterous manipulators and tactile sensors for minimally invasive robotic surgery, self-sensing, miniature pumps for drug delivery, IPMC snake-like robots, IPMC microgrippers for microorganisms manipulations, Graphene-based IPMCs and cellulose-based IPMCs or electroactive paper actuators (EAPap). Edited by the leading authority on IMPCs, the broad coverage will appeal to researchers from chemistry, materials, engineering, physics and medical communities interested in both the material and its applications.
(source: Nielsen Book Data)
Book
1 online resource (XI, 626 p. 246 ill., 84 illus. in color.) : online resource. Digital: text file; PDF.
  • Introduction.- Basic concepts.- Development.- Material properties.- Synthesis Techniques.- Chemistry.
  • (source: Nielsen Book Data)
This book introduces anisotropic innovations in liquid crystalline polymers as well as new nanocomposite materials and testing techniques. The authors detail the newest discoveries of material properties, material types and phases, and material characterization. This interdisciplinary work creates valuable links that strengthen the approach to the evolving field of liquid crystalline polymers/ materials.
(source: Nielsen Book Data)
Book
xiii, 226 pages : illustrations (some color) ; 26 cm.
  • Synthesis of chain-end functionalized glycopolymers via cyanoxyl-mediated free radical polymerization (CMFRP) / Valentinas Gruzdys [and others]
  • Protecting-group-free synthesis of well-defined glycopolymers featuring negatively charged oligosaccharides / Luca Albertin
  • Glycopolymers prepared by ring-opening metathesis polymerization followed by glycoconjugation using a triazole-forming "click" reaction / Ronald Okoth and Amit Basu
  • Protecting-group-free synthesis of glycopolymers and their binding assay with lectin and influenza virus / Tomonari Tanaka, Tadanobu Takahashi, and Takashi Suzuki
  • Carbohydrate-based initiators for the cationic ring-opening polymerization of 2-Ethyl-2-Oxazoline / Christine Weber [and others]
  • Heterofunctional glycopolypeptides by combination of Thiol-Ene chemistry and NCA polymerization / Kai-Steffen Krannig and Helmut Schlaad
  • Preparation of proteoglycan mimetic graft copolymers / Matt J. Kipper and Laura W. Place
  • Galactosylated polymer nano-objects by polymerization-induced self-assembly, potential drug nanocarriers / Mona Semsarilar, Irene Canton, and Vincent Ladmiral
  • Synthetic approach to biotinylated glyco-functionalized quantum dots : a new fluorescent probes for biomedical applications / Christian K. Adokoh, James Darkwa, and Ravin Narain
  • Surface modification of polydivinylbenzene microspheres with a fluorinated glycopolymer using Thiol-Halogen click chemistry / Wentao Song and Anthony M. Granville
  • Glycopolymer-grafted polymer particles for lectin recognition / Michinari Kohri, Tatsuo Taniguchi, and Keiki Kishikawa
  • Synthesis of non-spherical glycopolymer-decorated nanoparticles : combing Thiol-ene with catecholic chemistry / Xiao Li, Weidong Zhang, and Gaojian Chen
  • Synthetic approach to glycopolymer base nanoparticle gold(I) conjugate : a new generation of therapeutic agents / Christian K. Adokoh, James Darkwa, and Ravin Narain
  • Multivalent glycopolymer-coated gold nanoparticles / Sarah-Jane Richards [and others]
  • Modulation of multivalent protein binding on surfaces by glycopolymer brush chemistry / Kai Yu [and others]
  • Oriented immobilized sialyloligo-macroligand microarray / Satya Nandana Narla and Xue-Long Sun
  • Glycocalyx remodeling with glycopolymer-based proteoglycan mimetics / Mia L. Huang [and others].
This volume details methods and protocols for the synthesis and characterization of glycopolymers and their biomedical applications. Chapters are divided into three parts covering synthesis and characterization of glycopolymers; glycopolymer-nanoparticle conjugates; and surface immobilized glycopolymers. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Macro-Glycoligands: Methods and Protocols aims to ensure successful results in the further study of this vital field.
(source: Nielsen Book Data)
Biology Library (Falconer)
Book
1 online resource : illustrations.
Manufacturing and Novel Applications of Multilayer Polymer Films discusses the advancements in multilayer technology, including its capability to produce hundreds of layers in a single film by a melt coextrusion process. These engineered films can have significantly enhanced performance properties, allowing films to be made thinner, stronger, and with better sealing properties. As recent developments in feedblocks and materials have opened up a range of new possibilities, this book discusses different feedblocks, and viscosity and material considerations. It is the first comprehensive summary of the latest technology in multilayer film processing and related applications, and is written from a practical perspective, translating research into commercial production and real world products. The book provides fundamental knowledge on microlayer coextrusion processing technology, how to fabricate such structures, structure and properties of such microlayers, and potential applications, thus helping research scientists and engineers develop products which not only fulfill their primary function, but can also be manufactured reliably, safely, and economically.
Book
1 online resource.
  • Front Cover; Molecularly Imprinted Catalysts; Copyright; Contents; Contributors; Editors' Biographies; Foreword; Preface; 1
  • Molecularly Imprinted Polymers for Enzyme-like Catalysis: Principle, Design, and Applications; 1. Introduction; 2. Generic Profile of Molecular Imprinting; 3. Rationally Optimized Interactions within Imprinted Polymers; 4. Some Basic Issues in Imprinted Polymer Catalysts for Selective Catalysis; 5. Molecular Imprinting with Transition State Analogues as the Template; 6. Molecular Imprinting with Substrate as the Template
  • 7. Molecular Imprinting with Product as the Template8. Future Outlook of Molecular Imprinting in Catalysis; 9. Concluding Remarks; Acknowledgments; References; 2
  • Catalytically Active MIP Architectures; 1. Introduction; 2. Transition State Analogues as Templates in Abzyme Mimics; 3. Metal Complexes and Prosthetic Groups in Enzyme Mimics; 4. MIP-Enzyme Architectures; 5. Protein-Based MIPs; 6. Summary and Outlook; References; 3
  • Molecularly Imprinted Catalysts: Synthesis and Applications; 1. Introduction; 2. Design of MIPs for Catalytic Action
  • 3. Different Designs of MIPs for the Biomimetic Catalyst3.1 MIPs as Mimics of Hydrolytic Enzyme; 3.1.1 Ester Hydrolysis; 3.1.2 Stereoselective Hydrolysis; 3.1.3 Charged Hydrogen Bonding and Ester Hydrolysis; 3.1.4 Carbonate and Carbamate Hydrolysis; 3.1.5 Cellulose Hydrolysis; 3.2 MIP with Cholesterol Esterase Activity; 3.3 MIP Catalyst-Enhanced Elimination Reaction; 3.4 Diels-Alder Catalysis; 3.5 Metalloenzyme-Based MIP Catalysts; 3.6 MIP Catalyst for Isomerization Reactions; 4. Recent Progress Made in MIPs to Enhance Their Biomimetic Catalyst Property
  • 4.1 Intrinsic Factors for Enhancement of Biomimetic Catalyst Property4.1.1 High Enzyme Substrate Binding Affinities; 4.1.2 High Synergy between Recognition and Catalysis; 4.1.3 High Catalytic Turnover; 4.1.4 Substantial Rate Accelerations; 4.2 Extrinsic Factors for Enhancement of Biomimetic Catalyst Property; 4.2.1 Development of Computational Methodology Affiliated with MIPs as Biomimetic Catalyst; 5. Conclusion; References; 4
  • Advances and Challenges in the Design and Synthesis of Molecularly Imprinted Microspheres; 1. Introduction
  • 2. Progress in Design and Synthesis of Molecularly Imprinted Microspheres2.1 Methods of Initiation; 2.1.1 Controlled Radical Polymerization; 2.1.2 Iniferters; 2.1.3 Nitroxide-Mediated Polymerization; 2.1.4 Reversible Addition Fragmentation Polymerization; 2.1.5 Atom Transfer Radical Polymerization; 2.1.6 Porogens; 2.2 Cross-linkers and Functional Monomers; 2.3 Other Strategies; 3. Challenges in the Design and Synthesis of Molecularly Imprinted Microspheres; 4. Future Outlook: Processable Star MIPs; 5. Conclusion; References
  • 5
  • Molecularly Imprinted Polymers: Principle, Design, and Enzyme-Like Catalysis
Molecularly Imprinted Catalysts: Principle, Synthesis, and Applications is the first book of its kind to provide an in-depth overview of molecularly imprinted catalysts and selective catalysis, including technical details, principles of selective catalysis, preparation processes, the catalytically active polymers themselves, and important progress made in this field. It serves as an important reference for scientists, students, and researchers who are working in the areas of molecular imprinting, catalysis, molecular recognition, materials science, biotechnology, and nanotechnology.Comprising a diverse group of experts from prestigious universities and industries across the world, the contributors to this book provide access to the latest knowledge and eye-catching achievements in the field, and an understanding of what progress has been made and to what extent it is being advanced in industry.The first book in the field on molecularly imprinted catalysts (MIPs)Provides a systematic background to selective catalysis, especially the basic concepts and key principles of the different MIP-based catalystsFeatures state-of-the art presentation of preparation methods and applications of MIPsWritten by scientists from prestigious universities and industries across the world, and edited by veteran researchers in molecular imprinting and selective catalysis
Book
1 online resource : color illustrations. Digital: text file; PDF.
  • 1 Current optical biosensors in clinical practice 1.1 Biosensors 1.2 Enzyme-linked immunosorbent assay (ELISA) 1.3 Sandwich ELISA 1.3.1 Capture antibody immobilization 1.3.2 Washing procedure 1.3.3 Blocking step 1.3.4 Virus attachment 1.3.5 Primary antibody attachment 1.3.6 Secondary labeled antibody attachment and recording the signals 1.3.7 Evaluation of ELISA 1.4 Advantages and disadvantages of ELISA 1.5 Surface functionalization References 2 Alternative chemical approach 2.1 Proposed chemical alternative 2.2 Characterization techniques 2.2.1 Morphology analysis by scanning electron microscopy (SEM) 2.2.2 Topography analysis by atomic force microscopy (AFM) 2.2.3 Water-in-air contact angle measurement 2.3 Dengue fever References 3 Biochips Fabrication and surface characterization 3.1 Fabrication of the biochips 3.2 Morphology analysis of the biochips 3.3 Topography analysis of the biochips 3.4 Water-in-air contact angle measurement on the surface of biochips References 4 Application of the biochips in dengue virus detection 4.1 Sandwich ELISA 4.2 Dengue virus detection in sandwich ELISA assay 4.3 Physical immobilization of the target analyte on the biochips and performance of the assay in dengue virus detection 4.3.1 Detection range study 4.3.2 Calibration of the assay 4.3.3 Evaluation of the assay 4.4 Covalent immobilization of the target analyte on the biochips and performance of the assay in dengue virus detection 4.5 Immobilization of the target analyte by using amine-bearing spacers References Summary Appendix.
  • (source: Nielsen Book Data)
This book focuses on the creation and development of polymeric platforms (different compositions) from a specific polymer system. This system can be used as an adaptive technique for producing sensitive analytical devices, or for simple integration into existing bioanalytical tools in order to enhance the detection signal.
(source: Nielsen Book Data)
Book
1 online resource (IX, 234 pages) : illustrations (some color). Digital: text file; PDF.
  • Polymeric Hydrogels: A Review of Recent Developments.- Conducting Polymer Hydrogels.-Polysaccharide-Based Natural Hydrogels.- Protein-Based Hydrogels.- Sterculia Gum-Based Hydrogels for Drug Delivery Applications.-Antimicrobial Polymeric Hydrogels.- Bio-Polymer Based Hydrogel for the Decontamination of Organic Waste.-Chitosan and Starch-Based Hydrogels via Graft Copolymerization.
  • (source: Nielsen Book Data)
This book is concerned with polymeric hydrogels, which are considered as one of the most promising types of new polymer-based materials. Each chapter in this book describes a selected class of polymeric hydrogels, such as superabsorbent hybrid nanohydrogels, conducting polymer hydrogels, polysaccharide-based or protein-based hydrogels, or gels based on synthetic polymers. In this way, the book also addresses some of the fascinating properties and applications of polymeric hydrogels: they are three-dimensional, hydrophilic, polymeric networks that can absorb, swell and retain large quantities of water or aqueous fluids. In combination with metal nanoparticles, nanofibrils or nanowhiskers, which may be embedded in the gels, they find widespread applications, ranging from agriculture, and waste water treatment, over electronics, to pharmaceutical and biomedical applications. Applications mentioned in this book include electro sensors, capacitors, electromechanical actuators, and even artificial muscles.
(source: Nielsen Book Data)
Book
1 online resource.
Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy.
Book
1 online resource.

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