Book
1 online resource (xv, 99 pages) : illustrations Digital: text file; PDF.
  • Allergy - definition.- Allergy - fact file.- Possible allergens in our surroundings.- Mechanism of allergic reactions.- House dust mite allergy - an environmental enigma.- House dust mites - a precarious indoor allergen.- Dust mite allergy - evaluation procedures.- House dust mite allergy - Indian perspective.- Allergy and heredity.- Allergic manifestations and diagnosis.- Dust mite allergy management - common practices.
  • (source: Nielsen Book Data)9789811018244 20161010
This book discusses the Indian scenario concerning dust allergy, presenting case studies that reveal the practical aspects of allergies. A gradual increase in the incidence and prevalence of different allergic manifestations has been reported from various parts of the world including several developing countries like India, where the problem has recently surfaced due to the unplanned urbanization, rapid industrialization, metamorphic changes in the environment, and increased air pollution, as well as changes in life style, particularly the adoption of Western life styles and eating habits in the name of so-called modern living. The book is divided into the following chapters: Allergy - what is it?, Allergy - Fact File; Possible allergens in our surroundings; Mechanism of allergic reaction; House dust allergy - an environmental enigma; The mighty mites; Dermatophagoides - the potent indoor allergen; Dust mite allergy - evaluation procedure; House dust allergy - an Indian perspective; House dust allergy in Kolkata - a case study; Allergy & heredity; Allergic manifestations; Diagnostic procedures; and Treatment & prevention.
(source: Nielsen Book Data)9789811018244 20161010
Book
1 online resource (x, 345 pages) : illustrations (some color) Digital: data file.
  • 1. Chapter 1. General Physiology and Pathophysiology of Microglia in inflammation
  • Chapter 2. Inflammation and the Pathophysiology of Astrocytes in brain disorders
  • Chapter 3. Neuroinflammation in Huntington’s and related neurodegenerative disorders
  • Chapter 4. Brain infection and inflammation
  • Chapter 5. Neuroinflammation in Ischemic Stroke
  • Chapter 6. Innate and Adaptive Immune-Mediated Neuroinflammation in Parkinson’s Disease
  • Chapter 7. Brain cancer and inflammation
  • Chapter 8. Demylinating diseases and neuro-inflammation
  • Chapter 9. Obesity and neuro-inflammation
  • Chapter 10. Retinal disorder/degeneration and inflammation associated with it.
This unifying theme of this book—with sections on mechanisms of defense and neuropathogenesis, neurological diseases, infections of the nervous system, neuropharmacology, and novel therapies—is interactions of the immune and nervous systems. It also discusses the role of inflammation as a key mediator of different brain disorders. There have been significant scientific advances in the multidisciplinary field of neuroimmunology / neuroinflammation in the past decade, and this book, edited under the guidance of Professor P. N. Tandon, fosters communication between those who share an interest in this exciting area, including neuroscientists, immunologists, cell biologists, clinicians and neuropharmacologists.
Book
1 online resource (454 p.) Digital: data file.
  • Preface. 1. The skin lipidome under environmental stress - Technological platforms, molecular pathways and translational opportunities 2. Squalene and skin barrier function: From molecular target to biomarker of environmental exposure 3. Sunlight-induced DNA damage: molecular mechanisms and photoprotection strategies 4. Urocanic Acid and Skin Photodamage: New Light on an Old Chromophore 5. The Skin Extracellular Matrix as a Target of Environmental Exposure: Molecular Mechanisms, Prevention and Repair 6. Nitric Oxide Derivatives and Skin Environmental Exposure to light: From Molecular Pathways to Therapeutic Opportunities 7. Melanocortin 1 receptor (MC1R) as a global regulator of cutaneous UV responses: molecular interactions and opportunities for melanoma prevention 8. The Cutaneous Melanocyte as a Target of Environmental Stressors: Molecular Mechanisms and Opportunities 9. The Role of Epidermal p38 Signaling in Solar UV Radiation-induced Inflammation: Molecular Pathways and Preventive Opportunities 10. UV-Induced Chemokines as Emerging Targets for Skin Cancer Photochemoprevention 11. TLR3 and Inflammatory Skin Diseases: From Environmental Factors to Molecular Opportunities 12. Sirtuins and stress response in skin cancer, aging, and barrier function 13. Cutaneous Opioid Receptors and Stress Responses: Molecular Interactions and Opportunities for Therapeutic Intervention 14. Regulation of Cutaneous Stress Response Pathways by the Circadian Clock: From Molecular Pathways to Therapeutic Opportunities 15. Endocannabinoids and Skin Barrier Function: Molecular Pathways and Therapeutic Opportunities 16. The aryl hydrocarbon receptor (AhR) as an environmental stress sensor and regulator of skin barrier function: Molecular mechanisms and therapeutic opportunities 17. Biological cell protection by natural compounds, a second line of defense against solar radiation 18. The Cutaneous Microbiota as a Determinant of Skin Barrier Function: Molecular Interactions and Therapeutic Opportunities 19. Sensing Environmental Factors: The Emerging Role of Receptors in Epidermal Homeostasis and Whole-Body Health 20. The Cutaneous Circadian Clock as a Determinant of Environmental Vulnerability: Molecular Pathways and Chrono-pharmacological Opportunities 21. Psychological stress as a determinant of skin barrier function: Immunological pathways and therapeutic opportunities Index.
  • (source: Nielsen Book Data)9783319431550 20161010
It is now established that the interplay between environmental exposure and molecular stress response pathways plays a critical role in skin health and disease, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit patients in the near future. Coauthored by recognized international leaders in molecular and clinical biomedical sciences, this novel book provides a comprehensive perspective on environmental exposure-induced skin stress response pathways. Focusing on molecular opportunities targeting skin stress response pathways that are involved in cutaneous barrier function and repair, antimicrobial defense, immune regulation, inflammation, and malignant progression, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in skin health and disease with implications for small molecule therapeutic development.
(source: Nielsen Book Data)9783319431550 20161010
Book
1 online resource (viii, 391 pages) : illustrations Digital: text file; PDF.
  • Plague: a disease which changed the path of human civilization / Barbara Bramanti, Nils Chr. Stenseth, Lars Walløe, Xu Lei
  • Discovery of the plague pathogen: lessons learned / Ruifu Yang, Thomas Butler
  • Taxonomy of Yersinia pestis / Zhizhen Qi, Yujun Cui, Qingwen Zhang, Ruifu Yang
  • Physiology of Yersinia pestis / Robert R. Brubaker
  • Ecology of Yersinia pestis and the epidemiology of plague / Vladimir M. Dubyanskiy, Aidyn B. Yeszhanov
  • Genome and evolution of Yersinia pestis / Yujun Cui, Yajun Song
  • Pathology and pathogenesis of Yersinia pestis / Zongmin Du, Xiaoyi Wang
  • Genetic regulation of Yersinia pestis / Yanping Han, Haihong Fang, Lei Liu, Dongsheng Zhou
  • Yersinia pestis in the age of big data / Ruifu Yang, Vladimir L. Motin
  • Immunology of Yersinia pestis infection / Yujing Bi
  • Plague: clinics, diagnosis and treatment / Vladimir V. Nikiforov, He Gao, Lei Zhou, Andrey Anisimov
  • Plague vaccines: status and future / Wei Sun
  • Bacteriophages of Yersinia pestis / Xiangna Zhao, Mikael Skurnik
  • Perspectives on Yersinia pestis: a model for studying zoonotic pathogens / Ruifu Yang, Yujun Cui, Yujing Bi.
"This book addresses nearly every aspect of Y. pestis, approaching it from a new perspective. Topics covered include the history, epidemiology, physiology, ecology, genome, evolution, pathogenesis, host-pathogen interaction, big-data-driven research, vaccines, clinical aspects and future research trends. For centuries, scientists have sought to determine where Y. pestis, the most well-known bacterium and one that has caused a number of high-mortality epidemics throughout human history, comes from, what it is and how it causes the disease. This book works to answer these questions with the help of cutting-edge research results. It not only describes the history of plagues, but also stresses plagues effects on human civilization and explores the interaction of Y. pestis with hosts, vectors and the environment to reveal the evolution and pathogenesis. The book offers a valuable guide for researchers and graduate students studying Y. pestis, and will also benefit researchers from other fields, such as infectious diseases, other pathogens and system biology, sharing key insights into bacterial pathogen studies"--Publisher's description.
Book
1 online resource (xvi, 389 pages) : illustrations (some color)
  • HIV-associated Cancers: Overview
  • Epidemiology of AIDS-defining Malignancies
  • Epidemiology of non-AIDS Defining Malignancies
  • HIV Cancers in Resource-limited Regions
  • Kaposi's Sarcoma-associated Herpesvirus (KSHV)
  • Epstein Barr Virus (EBV)
  • Human Papillomavirus (HPV)
  • Merkel Cell Polymavirus (MCV)
  • Presentation and Pathogenesis of Kaposi's Sarcoma
  • Management of Kaposi's Sarcoma
  • Presentation and Pathogenesis of HIV Lymphomas
  • Diffuse Large B-Cell Lymphoma
  • Burkitt and Burkitt-Like Lymphoma
  • Primary Effusion Lymphoma
  • AIDS-related Central Nervous System Lymphoma
  • Plasmablastic and Other Lymphomas
  • Hodkin Lymphoma
  • Multicentric Castelman Disease
  • Cervical Cancer
  • Anal Cancer
  • Other HPV-Associated Cancers
  • Lung Cancer in HIV Infection
  • Hepattocellular Carcinoma in HIV-positive Patients
  • Merkel Cell Carcinoma and Other HIV-associated Skin Cancers
  • Conjuctival Carcinoma
  • Malignancies in Children with HIV Infection
  • cART and Supportive Care
  • Stem Cell Transplantation.
The association between AIDS and cancer was recognized from the beginning ofthe AIDS epidemic, when the appearance of Kaposi sarcoma in a cluster of youngmen was one of the first signs of this new disease. It was soon recognized that AIDSpatients are prone to develop a number of 'AIDS-defining' cancers: Kaposi sarcoma, lymphoma, and cervical cancer. The development of effective combination anti-HIVtherapy starting around 1996 converted AIDS from a death sentence to a manageabledisease and led to dramatic shifts in the epidemic. As this therapy was able to improveimmune function in patients, the incidence of most 'AIDS-defining' cancers decreased.There is a misconception, however, that AIDS has gone away. In fact, as AIDS patientsare living longer, the number of AIDS patients has more than doubled in the UnitedStates since 1996, and the AIDS population overall has increased in age. Also, as AIDSpatients are less likely to die of other complications, cancer is coming to the forefront as one of the most common causes of death in regions where AIDS drugs are widelyavailable.Moreover, the three 'AIDS-defining' cancers are now taking a back seat toa number of other HIV-associated cancers, such as Hodgkin lymphoma, lung cancer, and anal cancer. In the developing world, AIDS-associated cancers are a major publichealth problem, and in some regions of sub-Saharan Africa, Kaposi sarcoma is themost common tumor in men. In recent years, there has been a vast increase in our understanding of HIV-associatedcancers. We now know, for example, that most are caused by other viruses and thatthe main role of HIV and immunodeficiency is to provide a supportive environmentfor the viruses to multiply and for the cancers to develop. But there remain a numberof unanswered questions and a need for improved prevention and therapy. In the 28chapters of this book, written by some of the most renowned experts in this field, wepresent up-to-date information on the cancers associated with HIV infection. Thechapters cover the epidemiology of these cancers, as well as their pathogenesis, clinicalpresentation, and treatment. Dr. Robert Yarchoanis the Director of the Office of HIV and AIDS Malignancy andChief of the HIV and AIDS Malignancy Branch in the National Cancer Institute. Heplayed a major role in developing the first AIDS drugs. His research is now focused onAIDS-related cancers, especially Kaposi sarcoma and other cancers caused by Kaposisarcoma-associated herpesvirus.
Book
1 online resource (xi, 474 pages) : illustrations (some color).
  • Form and Function in the Digenea
  • The Systematics of the Trematoda
  • Schistosomiasis
  • Fascioliasis
  • Paragonimiasis
  • Liver Flukes
  • Intestinal Trematode Infections
  • Epidemiology of Trematode Infections
  • Diagnosis of Human Trematode Infections
  • Schistosomatidae and Diplostomidea
  • Amphistomes
  • Dicrocoeliidae Family
  • Selected Wildlife Trematodiasis.
Digenetic trematodes constitute a major helminth group that parasitize humans and animals, and are a major cause of morbidity and mortality. The diseases caused by trematodes have been neglected for years, especially as compared with other parasitic diseases. However, the geographical limits and the populations at risk are currently expanding and changing in relation to factors such as growing international markets, improved transportation systems, and demographic changes. This has led to a growing international interest in trematode infections, although factors such as the difficulties entailed in the diagnosis, the complexity of human and agricultural practices, the lack of assessments of the economic costs, or the limited number of effective drugs are preventing the development of control measures of these diseases in humans and livestock. In-depth studies are needed to clarify the current epidemiology of these helminth infections and to identify new and specific targets for both effective diagnosis and treatments. The main goal of this book is to present the major trematodes and their corresponding diseases in the framework of modern parasitology, considering matters such as the application of novel techniques and analysis of data in the context of host-parasite interactions and to show applications of new techniques and concepts for the studies on digenetic trematodes. This is an ideal book for parasitologists, microbiologists, zoologists, immunologists, professional of public health workers, clinicians, and graduate and post-graduate students.
Book
1 online resource (x, 152 pages) : color illustrations.
  • The Role of Antibody in Parasitic Helminth Infections.- Maternal Helminth Infections.- Helminth-M. TB Co-Infection.- Bacterial Infections and Vaccines.- Helpful or a Hindrance: Co-Infections of Helminth During Malaria.- Helminth Infections and HIV: Theories and Facts Regarding HIV and Helminth Interaction.
  • (source: Nielsen Book Data)9781493914883 20160617
Helminth infections are common, cause considerable pathology, and alter a host's immune profile. This can have important consequences not only on the host's ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question. This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host's anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child's immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies.
(source: Nielsen Book Data)9781493914883 20160617
Book
1 online resource (ix, 416 pages) : illustrations (some color)
  • Introduction
  • Brain: Overview
  • Major depressive disorder
  • Schizophrenia
  • Epilepsy
  • Parkinson's disease
  • Alzheimer's disease
  • Migraine and cluster headache
  • Multiple sclerosis
  • Down syndrome
  • Eye: Overview.-Age-related macular degeneration
  • Glaucoma
  • Teeth and bones: Overview: Dental caries
  • Osteoporosis
  • Joints: Overview.-Osteoarthritis
  • Rheumatoid arthritis
  • Gastrointestinal tract: Overview
  • Peptic ulcer disease
  • Gastroenteritis
  • Lactose intolerance
  • Colorectal cancer
  • Pancreas: Overview
  • Diabetes mellitus
  • Liver: Overview
  • Cirrhosis
  • Fat tissue: Overview
  • Metabolic syndrome
  • Lung: Overview
  • Asthma
  • COPD.-Community-acquired pneumonia
  • Heart: Overview.-Atherosclerotic heart disease
  • Heart failure
  • Blood vessels: Overview
  • Stroke
  • Varicose Veins
  • Blood: Overview
  • Sickle Cell Disease
  • Hyperlipidemia
  • Immune system: Overview
  • Fever
  • Sepsis
  • Allergies
  • Kidney: Overview
  • Hypertension
  • Chronic kidney disease
  • Gout and hyperuricemia
  • Urinary tract infections
  • Kidney stones
  • Reproductive system: Overview
  • Breast cancer
  • Prostate cancer
  • Cancer: Overview.
"Metabolism of Human Diseases" examines the physiology of key organs (e.g. brain, eye, lung, heart, blood vessels, blood, immune system, gastrointestinal tract, pancreas, liver, fat tissue, kidney, reproductive system, teeth, bone and joints) and how defective metabolism and signaling pathways within these organs contribute to common human diseases. The latter include depression, schizophrenia, epilepsy, Parkinson's disease, Alzheimer's disease, migraine, multiple sclerosis, Down syndrome, macular degeneration, glaucoma, asthma, COPD, pneumonia, atherosclerotic heart disease, heart failure, stroke, varicose veins, Sickle cell disease, hyperlipidemia, fever, sepsis, allergies, peptic ulcer, gastroenteritis, lactose intolerance, colon cancer, diabetes, cirrhosis, metabolic syndrome, hypertension, chronic kidney disease, gout, urinary tract infections, kidney stones, dental caries, osteoporosis, osteoarthritis, rheumatoid arthritis, breast cancer and prostate cancer. The book also describes commonly used drugs and explains their molecular targets. It provides the first comprehensive and detailed summary of the metabolism of individual organs and their physiological and pathological functioning. Thus it serves as a useful supplement to previous textbooks of human physiology. "Metabolism of Human Diseases" is a must-have, state-of-the-art textbook written by International experts for graduate students, postdocs and scientists in metabolic research, biochemistry, physiology and pharmacy as well as for physicians interested in molecular mechanisms underlying common human diseases.
Book
1 online resource (x, 351 pages) : illustrations (some color)
  • Preface
  • The therapeutic role of microRNAs in human gliomas
  • miRNA expression and functions in glioma and glioma stem cells
  • The role of miRNAs in lung cancer drug resistance and targeted therapy
  • The Potential Role of MicroRNA-Based Therapy for Lung Cancer Stem Cells
  • State of our knowledge on miRNA targeted therapy in Lung Cancer
  • miRNA-based Ovarian Cancer Diagnosis and Therapy
  • Application of microRNA in the treatment and diagnosis of cervical cancer
  • Overcoming Drug Resistance in Colorectal Cancer by microRNAs
  • MicroRNAs as novel targets in liver cancer- facing the clinical challenge
  • MicroRNA based therapeutic strategies for cancer: Emphasis on advances in renal cell carcinoma
  • Modulating microRNA expression for the therapy of pancreatic cancer
  • MicroRNA targeted therapy for overcoming drug resistance, reversal of EMT and elimination of cancer stem cells in prostate and pancreatic cancer.-Modulation of deregulated miRNAs for targeted therapy in thyroid cancer
  • miRNA-targeted therapies in the most prevalent pediatric solid tumors
  • Targeting Immune System Through Targeting miRNA For Cancer Therapy.-miRNA regulation of DNA damage repair proteins in cancer cells: interplay of ATM, TRAIL and miRNA
  • miRNA regulation of VEGF/VEGFR signaling
  • Systems Biology Approaches in the Design of Effective miRNA-Targeted Therapeutics. Index.
Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes, and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs), and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research.
Book
1 online resource (vii, 78 pages) : illustrations (some color).
  • Role of miRNAs and their Target Genes in Breast Cancer Metastasis
  • Molecular Pathogenesis of Breast Cancer and the Role of MicroRNAs
  • Epidemiology, Risk Factors, Treatment and Prevention of Breast Cancer Metastases
  • Clinical Perspectives: Breast Cancer Brain Metastasis
  • Molecular targeted therapy for brain metastatic breast cancers: Current Updates.
This SpringerBrief gives the latest research on the role of miRNAs in breast cancer metastasis. MicroRNAs (miRNAs) are recently described small endogenous noncoding RNAs implicated in the posttranscriptional control of gene expression. These tiny molecules are involved in developmental, physiologic phenomenon as well as pathologic processes including cancers. In fact, miRNAs have emerged as critical regulators of cancer progression, invasion and metastasis. This is mainly because a single miRNA can affect several downstream genes and signaling pathways with oncogenic or tumor suppressor actions depending on the target genes affected. Due to this multimodal downstream signaling effects, these small endogenous molecules hold great promise in metastasis prevention and treatment. Modulating the activity of miRNAs can provide opportunities for novel cancer interventions. Targeting miRNAs could become a novel prognostic and therapeutic strategy to prevent the future development of metastasis. Thus, miRNAs could also serve as a potential targets for anti-metastatic therapy. The book explores how the expression of miRNAs in the primary tumor could be silenced using antagomirs (chemically modified anti-miRNA oligonucleotides), which could prevent the development of metastasis; whereas once metastasis develops then it could be treated with miRNA mimics for inducing its expression for the treatment. Therefore, development of miRNA-based prophylactic therapies could serve as precision and personalized medicine against future development of metastasis of breast and other cancers.
Book
1 online resource (vi, 223 pages) : illustrations (some color).
  • Oxidation and inflammation, a molecular link between non-communicable diseases.-Oxidative stress and DNA damage in obesity-related tumorigenesis
  • High density lipoproteins and ischemia reperfusion injury: The therapeutic potential of HDL to modulate cell survival pathways.-The DING family of phosphate binding proteins in inflammatory diseases
  • Inflammation, infection, cancer and all that...The role of paraoxonases
  • Autophagy is an inflammation-related defensive mechanism against disease
  • Delta-5 and Delta-6 Desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease
  • Systemic inflammation, intestine and paraoxonase-1.-Serotonin modulation of macrophage polarization: inflammation and beyond
  • Energy metabolism and metabolic sensors in stem cells: The metabostem crossroads of aging and cancer
  • Molecular promiscuity of plant polyphenols in the management of age-related diseases: far beyond their antioxidant properties
  • Postprandial Inflammation: Targeting glucose and lipids
  • Dynamic interplay between metabolic syndrome and immunity
  • The axis AGE-RAGE-soluble RAGE and oxidative stress in chronic kidney disease
  • The chemokine (C-C motif) ligand 2 in neuroinflammation and neurodegeneration.
Oxidative stress and inflammation underpin most diseases; their mechanisms are inextricably linked. For example, chronic inflammation is associated with oxidation, anti-inflammatory cascades are linked to decreased oxidation, increased oxidative stress triggers inflammation, and redox balance inhibits the inflammatory cellular response. Whether or not oxidative stress and inflammation represent the causes or the consequences of cellular pathology, they contribute significantly to the pathogenesis of non-communicable diseases. The incidence of obesity and other related metabolic disturbances are rising, as are age-related diseases due to progressively aging populations. Interrelations between the mechanisms of oxidative stress and of inflammatory signaling and metabolism are, in the broad sense of energy transformation, being increasingly recognized as part of the problem in non-communicable diseases. The book Oxidative Stress andInflammation in Non-communicable Diseases: Molecular Mechanisms andPerspectives in Therapeutics is an update on the latest research on the molecular basis of non-communicable diseases and the search for possible therapeutic alternatives. The authors of this monograph are experts in their field, and the book as a whole, provides an overview of the biochemical alterations underlying diseases such as cardiovascular disease, cancer, obesity, renal disease, neurological diseases and diabetes, emphasizing those aspects that they share in common. We hope that this book will be useful for researchers in biomedicine, and also for physicians interested in finding the root causes of the disease, as well as for post-graduate students in biochemistry, molecular biology, nutrition or medicine.
Book
1 online resource (viii, 93 pages) : color illustrations
  • Mechanisms of immunopathology of leishmaniasis
  • Update on Leishmania mediators that promote immune evasion
  • Paratransgenic Control of Leishmaniasis: New Developments
  • Current status and future challenges for the development of Genetically Altered Live Attenuated Leishmania vaccines
  • Reservoir control strategies for Leishmaniasis: past, present and future
  • Treatment modalities for cutaneous and visceral leishmaniasis.
This book discusses recent developments in several laboratories studying leishmaniasis. Sequencing of the human genome, as well as of the leishmania genome, has led to significant advances in our understanding of host-immune responses against leishmania, and mechanisms of infection-induced pathology, which is responsible for morbidity and mortality. Pathogenesis of Leishmaniasis focuses on the latest basic research into leishmaniasis, but also addresses how advances in understanding can be applied to prevention, control and treatment of what the WHO has classified a neglected tropical disease.
Book
1 online resource (xiv, 185 pages) : color illustrations.
  • Irritable Bowel Syndrome and Microbial Pathogenesis.- Microbes in Colon Cancer and Inflammatory Bowel Disease.- The Role of Microbes in Obesity.- Microbes in the Pathogenesis of Diabetes Mellitus.- Asthma and Microbes: a New Paradigm.- Chronic Fatigue Syndrome: Searching for a Microbial Etiology.- Can Microbes Play a Role in the Pathogenesis of Alzheimer Disease?- Multiple Sclerosis and Microbes.- The Role of Infections and Microbes in Atherosclerosis.
  • (source: Nielsen Book Data)9781493916696 20160617
This new volume in the series Emerging Infectious Diseases of the 21st Century is a novel book on the role of microbes in the pathogenesis of common and disabling non-infectious diseases. New insights have emerged over the past several years suggesting that our commensal microflora of the gut is extremely important in regulating physiological and immune functions of the body. Covered are the perturbations of the normal composition of our endogenous microbiota, influenced by diet and genetic predispositions, as well as the mechanisms to produce common disorders such as obesity, diabetes, irritable bowel syndrome, colon cancer and atherosclerotic vascular diseases. Also explored is the evidence suggesting that predisposition to increasingly common afflictions such as asthma and multiple sclerosis is influenced, in combination with our genetic composition, by early life exposure to environmental microbes and the time of onset of common viral infections. Chapters provide the most recent information on these disorders with regards to epidemiology, current concepts on pathogenesis and mechanisms of their biology, recent research and data on the role of microbes, analysis of their validity and conclusive remarks and areas for future research. The Role of Microbes in Common Non-Infectious Diseases is an excellent resource for both physicians and investigators from a broad range of disciplines that will help to stimulate new concepts of disease pathogenesis and lead to the unraveling of their mechanisms of diseases and to novel treatments.
(source: Nielsen Book Data)9781493916696 20160617
Book
1 online resource (xviii, 192 pages) : illustrations (some color)
  • Introduction
  • Formation of UPD
  • UPD in diagnostics and genetic counseling
  • UPD related syndromes caused by imprinting
  • Maternal UPD by chromosome
  • Paternal UPD by chromosome
  • UPD of unclear parental origin by chromosome
  • UPD of multiple chromosomes or chromosomal regions
  • Acquired UPD
  • Patient organizations in connection with UPD-. Glossary-. References
  • Index.
This book focus on genetic diagnostics for Uniparental Disomy (UPD), a chromosomal disorder defined by the exceptional presence of a chromosome pair derived from only one parent, which leads to a group of rare diseases in humans. First the molecular and cytogenetic background of UPD is described in detail; subsequently, all available information of the various chromosomal origins and the latest findings on genotype-phenotype correlations and clinical consequences are discussed. Numerous personal reports from families with a child suffering from a UPD-induced syndrome serve to complement the scientific and clinical aspects. Their experiences with genetic counseling and living with a family member affected by this chromosomal aberration present a vivid picture of what UPD means for its victims.
Book
1 online resource (xix, 430 pages) : illustrations (some color)
  • A Short History of Virology
  • What is a Virus?- A History of Cell Culture
  • Discovery of Bacteriophage
  • Beginnings of MolecularBiology
  • History of Immunology
  • Interferons
  • Cancer and Viruses
  • Smallpox
  • Yellow Fever
  • Influenza
  • Poliovirus and Other Picornaviruses
  • Hepatitis
  • Herpes Viruses
  • HIV and AIDS
  • Phage Therapy and the Future
  • Viral Oncolysis or Virotherapy
  • Gene Therapy and Viral Vectors
  • Vaccine Against Virus Infections
  • Emerging Viruses
  • Manufacturing Viruses
  • Viruses as Biological Weapons.
Milton Taylor, Indiana University, offers an easy-to-read and fascinating text describing the impact of viruses on human society. The book starts with an analysis of the profound effect that viral epidemics had on world history resulting in demographic upheavals by destroying total populations. It also provides a brief history of virology and immunology. Furthermore, the use of viruses for the treatment of cancer (viral oncolysis or virotherapy) and bacterial diseases (phage therapy) and as vectors in gene therapy is discussed in detail. Several chapters focus on viral diseases such as smallpox, influenza, polio, hepatitis and their control, as well as on HIV and AIDS and on some emerging viruses with an interesting story attached to their discovery or vaccine development. The book closes with a chapter on biological weapons. It will serve as an invaluable source of information for beginners in the field of virology as well as for experienced virologists, other academics, students, and readers without prior knowledge of virology or molecular biology.
Book
1 online resource (XI, 334 pages) : illustrations (some color).
  • B-cell receptor and antigens in CLL
  • The CLL cell microenvironment
  • Acquired genomic copy number aberrations in CLL
  • Recurrent gene mutations in CLL
  • TP53 aberrations in CLL
  • Gene expression and epigenetic deregulation
  • Apoptosis deregulation in CLL
  • Richter s Syndrome
  • Molecular biomarkers in chronic lymphocytic leukemia
  • Critical Signal Transduction Pathways in CLL
  • Immunotherapies in CLL
  • Novel therapeutic agents in CLL
  • Inherited susceptibility to CLL
  • miR deregulations in CLL.
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course. While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and translational biology of CLL. In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings. This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply. Intentionally, the many aspects and nuances of CLL clinical care that can only really be appreciated through direct patient care are not covered here, but instead, the book presents basic aspects of CLL that underlie many of the contemporary decisions that are made in CLL research and clinical settings. We hope that this book will critically inform the community and stimulate interest in CLL, which will ultimately translate into better CLL research, prognostication and therapy, with the end goal of providing a better outlook for patients afflicted with this common leukemia.
Book
1 online resource (xiii, 407 pages) : illustrations (some color)
  • miRNA biogenesis and function
  • miRNAs in cancer progression
  • MicroRNA, DNA repair and cancer
  • Role of microRNAs in stem cells regulation and tumorigenesis in Drosophila
  • MicroRNAs in stem cells and cancer stem cells
  • MicroRNAs in epithelial mesenchymal transition and breast cancer progression
  • MicroRNAs in the development and progression of breast cancer
  • The role of microRNAs in hematopoietic stem cells and leukemia development
  • MiRNA and chronic lymphocytic leukemia
  • The role of miRNAs in the development of normal pancreas and pancreatic cancer, and their roles in tumor progression
  • Epigenetic regulation of microRNA genes in colorectal cancer
  • MicroRNAs in the development and progression of kidney cancer
  • MicroRNAs in the development and progression of skin cancer
  • MicroRNAs in the Development and Progression of Prostate Cancer
  • MicroRNAs in development and progression of ovarian cancer
  • MicroRNA and Cancer Drug Resistance
  • Microvesicular Transfer of microRNA in Tumor Microenvironment
  • MicroRNA cancer therapeutics and the challenge of drug delivery
  • MicroRNA and Drug Delivery.
MicroRNAs (miRNAs) are small 22-nucleotides long non-coding RNAs that regulate the gene expression through translational repression and mRNA degradation in varieties of species. miRNAs play regulatory role in several fundamental biological processes from normal development to regulation of stem cells, cancer stem cells and various human diseases including cancer. miRNAs can be used as potential biomarkers for disease diagnosis and have been considered potential therapeutic strategies in cancer treatment. This is a timely and specialized book providing the current understanding of miRNAs and their potential application in cancer diagnosis, prognosis, and therapeutic strategies in cancer treatment. This book will be a valuable source of information for the scientists in the field of cancer research as well as undergraduate and graduate students who want to pursue their research careers in cancer biology.
Book
1 online resource (viii, 373 pages) : illustrations (some color).
This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer, and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer, and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.
Book
1 online resource (xvii, 600 pages) : illustrations (some color)
  • The Blood Brain Barrier
  • Immune Cell Trafficking in the Central Nervous System
  • General Physiology and Pathophysiology of Microglia Inflammation and the Pathophysiology of Astrocytes in Neurodegenerative Diseases
  • Oxidative stress, neuroinflammation, and neurodegeneration
  • Peripheral Neuroimmune Interactions and Neuropathic Pain
  • Innate and Adaptive Immune-Mediated Neuroinflammation and Neurodegeneration in Parkinson's Disease
  • Multiple sclerosis: impact on functioning of the blood-brain barrier
  • Neuroinflammation in Alzheimer's disease
  • Neuroinflammation in Huntington's Disease
  • Neuroinflammation and immune regulation in ischemic stroke: identification of new pharmacological targets
  • HIV/NeuroAIDS
  • Herpes Simplex Virus Infections Of The Central Nervous System
  • Congenital Cytomegalovirus Disease
  • Japanese Encephalitis: A Tale of Inflammation and Degeneration in the Central Nervous System
  • The biology and clinical consequence of infection with the human polyomavirus JCV
  • Role of Retrovirus-Induced Transactivator Proteins in Neuroinflammatory Disease
  • Immunopathogenesis of bacterial meningitis
  • Cerebral Malaria
  • HIV and Cocaine Interplay in HIV-associated Neurocognitive Disorders
  • Methamphetamine Neurotoxicity and Neuroinflammatory Processes
  • Drugs of Abuse and NeuroAIDS: Opiates
  • Cannabinoids
  • Alcohol and Neurodegeneration
  • Cell-Based Drug Delivery for Improving Antiretroviral Therapeutic Outcomes
  • Immunomodulatory Therapeutics for Neurodegenerative Diseases
  • Therapeutic Potential Of Cannabinoids.
State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases, and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer's disease, Parkinson's disease, stroke, viral encephalitis, and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.
Book
1 online resource (xiii, 343 pages) : color illustrations
  • The Foundation of IBD Genetics, Human and Animal Studies
  • The Genetic and Molecular Makeup of Inflammatory Bowel Disease
  • Pathogenetic Pathways in Inflammatory Bowel Disease
  • Concluding Remarks and Future Perspectives.
Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn?s disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.

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