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1. Priming of T cell responses [electronic resource] : part 1 of 2 [2017]

Description
Video — 1 online resource (1 streaming video file (30 min.) : color, sound).
Summary
  • Contents: T cell priming
  • Cells involved in priming
  • T cell and dendritic cell signals and activation.
Online

2. Priming of T cell responses [electronic resource] : part 2 of 2 [2017]

Description
Video — 1 online resource (1 streaming video file (19 min.) : color, sound).
Summary
  • Contents: T cell priming
  • Modulation of T cell priming
  • Tumor microenvironment
  • Cancer immunotherapy
  • Immune aging.
Online

3. Immunodeficiencies and pathologies associated with mutations in STIM/ORAI [electronic resource] [2012]

Description
Video — 1 online resource (1 streaming video file (38 min.) : color, sound).
Summary
  • Contents: STIM/Orai
  • two major molecular components of the calcium entry pathways observed in all tissues and associated to several physiological functions
  • Mutations causing immunodeficiencies and cancer by altering calcium homeostasis.
Online

4. GLP [electronic resource] : planning, recording, and archiving [2013]

Description
Video — 1 online resource (1 streaming video file (25 min.) : color, sound).
Summary
  • Contents: Prescriptive documents
  • Study plan
  • Pivotal document
  • GLP requirements for contents and amendments
  • Master schedule
  • Regulatory inspectors' requests
  • Descriptive documents
  • Raw data
  • Before and during data recording
  • ALCOA
  • Data management
  • Carousel loading
  • Data audit trail
  • Source of data generated
  • Retaining data in the archive
  • Associated documentation
  • Environmental data
  • Concentric series
  • Archive function
  • Designated manager
  • Movement of material into the archive
  • Retrieval of material
  • History of document
  • SOP-security
  • Conditions which minimise deterioration
  • Archive indexing
  • Electronic archiving
  • Data type / Licence for sale and archive duration
  • Difficulties in archiving
  • Discarding archived data.
Online

5. Inferring relatedness [electronic resource] [2016]

Description
Video — 1 online resource (1 streaming video file (25 min.) : color, sound).
Summary
  • Contents: Genetic consequence of relatedness
  • From pedigree to genome
  • IBD, Identity-By-Descent
  • Kinship coefficient
  • Inbreeding Coefficient
  • Identity Coefficients
  • Models and methods to infer IBD from genotypes: Single-point, Segmental sharing, Multi-point (hidden Markov model)
  • Applications: Population Genetics, Disease Gene Mapping.
Online

6. Glucocorticoids, inflammation and bone loss [electronic resource] [2015]

Description
Video — 1 online resource (1 streaming video file (28 min.) : color, sound).
Summary
  • Contents: Direct & indirect effects of glucocorticoids on bone
  • Management of Glucocorticoid-Induced Osteoporosis (GIOP)
  • Inflammation and bone loss in back pain & rheumatoid arthritis (RA)
  • Cytokines, T lymphocytes & autoimmunity in bone loss
  • Sclerostin inhibition, PTH and inflammation effects on bone formation
  • Anti-TNF effects on bone remodeling, BMD and fractures.
Online

7. Cannabinoid type 1 receptors in astrocytes [electronic resource] [2014]

Description
Video — 1 online resource (1 streaming video file (37 min.) : color, sound).
Summary
  • Contents: Mechanism of action of cannabinoid type 1 receptors (CB1)
  • Endocannabinoids (ECBs) and their role as retrograde neurotransmitters
  • The Cre/loxP system
  • CB1 in neurons and in astrocytes
  • CB1 deletion in specific neuronal populations
  • Cannabinoids and working memory via LTD in vivo (NMDAR, AMPAR, neuronal CB1R, astroglial CB1R)
  • Testing working memory (Delayed non-matching to sample T-maze test & Delayed matching to place in Morris water maze).
Online

8. Application of proteomics in fetal and neonatal medicine [electronic resource] [2013]

Description
Video — 1 online resource (1 streaming video file (33 min.) : color, sound).
Summary
  • Contents: Application of proteomics in fetal and neonatal medicine
  • Principles
  • Samples
  • Techniques
  • Statistics
  • Application to obstructive nephropathy in newborns
  • Application in neonatal medicine
  • Conclusion.
Online

9. The genetic structure of Mycobacterium tuberculosis [electronic resource] : insights into genome organisation and evolution of the causative agent of tuberculosis [2013]

Description
Video — 1 online resource (1 streaming video file (34 min) : color, sound).
Summary
  • Contents: Mycobacterium tuberculosis
  • genome information
  • essential genes- virulence genes
  • type VII secretion system involved in virulence and host pathogen interaction- genomics and evolution of tuberculosis-causing mycobacteria.
Online

10. Skin side effects targeted anti-EGFR and anti-BRAF therapies [electronic resource] [2013]

Description
Video — 1 online resource (1 streaming video file (50 min.) : color, sound).
Summary
  • Contents: Clinical presentation of skin adverse events occurring during anti-EGFR, anti-MEK and anti-BRAF agents
  • Mechanisms underlying skin manifestation of targeted anticancer agents
  • Management of the patients presenting with skin adverse events due to targeted anticancer agents.
Online

11. Transcription factors in macrophage differentiation [electronic resource] [2012]

Description
Video — 1 online resource (1 streaming video file (39 min.) : color, sound).
Summary
  • Contents: Control of cellular identity and cell numbers
  • Gain and loss of function approaches
  • Transcription factor/cytokine interplay
  • Mechanism: transcription factor levels, balance and combinatorial control
  • Enhancer definition of macrophage identity
  • Differentiation and cell cycle control.
Online

12. Proteins that bind methylated DNA [electronic resource] [2011]

Description
Video — 1 online resource (1 streaming video file (31 min.) : color, sound).
Summary
  • Contents: Introductory notions: distribution, abundance, and consequences of DNA methylation
  • The methyl-binding proteins: who they are, how they were found
  • What do the methyl-binding proteins do? Four examples
  • Unresolved questions and future perspectives
  • References.
Online

13. Metabolomics data analysis in the context of metabolic networks [electronic resource] [2018]

Description
Video — 1 online resource (1 streaming video file (50 min.) : color, sound).
Summary
  • Contents: Metabolic networks
  • Reconstructing metabolic networks
  • Mapping metabolites in genome-scale networks
  • The challenge of identifiers
  • Structure and algorithms of metabolic networks
  • Using biomarkers in biochemical networks
  • Building subnetworks based on metabolic profiles.
Online

14. The future of influenza vaccines [electronic resource] [2013]

Description
Video — 1 online resource (1 streaming video file (30 min.) : color, sound).
Summary
  • Contents: Influenza virion structure
  • Available flu vaccines
  • Problems with current inactivated vaccines
  • Live attenuated vaccines
  • Subunit vaccine
  • New, recently licensed vaccines
  • Flu vaccines in development
  • Experimental vaccines
  • Issues with pandemic vaccines
  • Universal influenza vaccines
  • The HA protein.
Online

15. Neuronal-glial anatomical plasticity in the hypothalamus [electronic resource] [2013]

Description
Video — 1 online resource (1 streaming video file (34 min.) : color, sound).
Summary
  • Contents: Anatomical remodelling of the hypothalamo-neurohypophysial system during specific physiological conditions
  • Characterisation of this remodelling by reduction in the astrocytic coverage of manocellular neurons and their synapses
  • Electrophysiological approaches show changes in the glial environment of neurons and synapses can dramatically alter synaptic functions
  • The hypothalamo-neurohypophysial system as an experimental model to study the contribution of astrocytes to synaptic transmission and plasticity.
Online

16. Antiviral therapy of chronic Hepatitis B virus infections [electronic resource] : is resistance still a challenge? [2011]

Description
Video — 1 online resource (1 streaming video file (62 min.) : color, sound).
Summary
  • Contents: Hepatitis B virus
  • Chronic hepatitis B
  • Interferon
  • Nucleoside analogs
  • Viral resistance
  • Treatment management.
Online

17. Mitochondria in reproduction and fertility [electronic resource] : part 1, mitochondria & gametes [2018]

Description
Video — 1 online resource (1 streaming video file (31 min.) : color, sound)
Summary
  • Contents: Introduction to the role of mitochondria in embryonic development
  • Mitochondrial life cycle, dynamics, biogenesis and mitophagy
  • Mitochondria and gametes: in spermatozoa and spermatogenesis, in oocyte and oogenesis
  • The bottleneck theory
  • The importance of mtDNA content in oocyte competence
Online

18. Mitochondria in reproduction and fertility [electronic resource] : part 2, mitochondria & embryo [2018]

Description
Video — 1 online resource (1 streaming video file (30 min.) : color, sound)
Summary
  • Contents: Mitochondria and embryogenesis
  • Mitochondria and ovarian ageing
  • The role of cumulus granulosa cells
  • Mitochondrial genetics and fertility
  • Targeting mitochondria to improve oocyte quality
Online

19. Education and tuning of natural killer cells [electronic resource] [2009]

Description
Video — 1 online resource (1 streaming video file (53 min.) : color, sound).
Summary
  • Contents: Innate immunity
  • Natural killer cells
  • NK cell recognition strategies
  • ITIM-bearing receptors
  • NK cell education via MHC class I recognition
  • Clinical manipulation of MHC class I recognition by NK cells.
Online

20. Identification of host defenses in the Drosophila gut using genome-scale RNAi [electronic resource] [2014]

Description
Video — 1 online resource (1 streaming video file (37 min.) : color, sound).
Summary
  • Contents: Why use drosophila to study immunity?
  • Drosophila digestive tract
  • Intestinal barriers against pathogens
  • The imd pathway in preventing infection
  • Serratia marcescens, an opportunistic pathogen
  • Genome wide RNA-I screening to identify essential genes for host defense
  • Gene ontology of the hits from RNA-I screening
  • The JAK/STAT pathway
  • The components of host defenses to infections
  • Serratia hemolysins.
Online

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