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Collection
Stanford Project for Open Knowledge in Epidemiology (SPOKE)
Background: Two recent randomized trials produced discordant results when testing cardiovascular disease (CVD) benefits and harms of treating blood pressure (BP) to a low level. Objective: To perform a theoretical modeling study to identify whether large, clinically important differences in benefit and harm among patients (heterogeneous treatment effects, HTEs) can be hidden within, and explain discordance between, “treat-to-target” BP trials. Design: Microsimulation Data: Results of two trials comparing standard (treat to systolic BP <140mmHg) to intensive (<120 mmHg) BP treatment, and data from the National Health and Nutrition Examination Survey (2013-2014). Target population: U.S. adults Time Horizon: 5 years Interventions: BP treatment Outcome measures: CVD events and mortality Results of base-case analysis: Clinically important HTEs could explain differences in outcomes between two trials of intensive BP treatment, particularly diminishing benefit with each additional BP agent (e.g., adding a 2nd agent to 1 agent reduces CVD risk, hazard ratio = 0.61, but adding a 4th agent to a 3rd has no benefit), and increasing harm at low DBP. Results of sensitivity analysis: Conventional “treat-to-target” trial designs had poor (<5%) statistical power to detect the HTEs despite large samples (N>20,000), and produced biased effect estimates. By contrast, a trial with sequential randomization to more intensive treatment achieved >80% power and unbiased HTE estimates, with samples as low as N = 3,500. Limitations: We explored HTEs as a function of the number of BP medications only. Simulated aggregate data from the trials were used as model inputs, as individual participant data were not available. Conclusions: Clinically important heterogeneity in intensive BP treatment effects remains undetectable through conventional trial designs, but detectable through sequential randomization trial designs.
Collection
Stanford Research Data
This code package contains a set of R functions for creating MDS and dendrogram visualizations of multi-category confusion matrices. The code includes options for normalizing and symmetrizing the confusion matrix, and for converting the pairwise similarities to distance measures. In addition, the code offers customization options for plotting labels and images, and for plotting series of MDS plots or dendrograms. Along with R functions, this code package includes scripts with step-by-step examples for creating and customizing each type of plot. Total size of the compressed .zip archive is around 400 KB.
Software/Multimedia
1 online resource (streaming video file) (52 minutes): digital, .flv file, sound Sound: digital. Digital: data file.
Filmmaker Daphne Valerius's award-winning documentary The Souls of Black Girls explores how media images of beauty undercut the self-esteem of African-American women. Valerius surveys the dominant white, light-skinned, and thin ideals of beauty that circulate in the culture, from fashion magazines to film and music video, and talks with African-American girls and women about how these images affect the way they see themselves. The film also features powerful commentary from rapper and activist Chuck D, actresses Regina King and Jada Pinkett Smith, PBS news anchor Gwen Ifill, cultural critic Michaela Angela Davis, and others.
Software/Multimedia
1 computer optical disc : digital, sound, color ; 4 3/4 in. Sound: digital; optical. Video: Blu-ray. Digital: program file; Blu-ray; all regions.
Several years after his last adventure, retired fortune hunter, Nathan Drake, is forced back into the world of thieves. With the stakes much more personal, Drake embarks on a globe-trotting journey in pursuit of a historical conspiracy behind a fabled pirate treasure. His greatest adventure will test his physical limits, his resolve, and ultimately what he's willing to sacrifice to save the ones he loves.
Media & Microtext Center
Software/Multimedia
1 computer disc ; 4 3/4 in.
Media & Microtext Center
Software/Multimedia
1 computer disc ; 4 3/4 in. Digital: text file. RTF.
Archive of Recorded Sound
Collection
Stanford Research Data
Background: Stereotactic laser ablation and neurostimulator placement represent an evolution in staged surgical intervention for epilepsy. As practice evolves, optimal targeting will require standardized outcome measures that compare electrode lead or laser source with post-procedural changes in seizure frequency. Since non-lesional seizure foci are localized to the hippocampus by semiology and electrophysiology, stereotactic indirect targeting may be required for optimal targeting and outcome. We propose and present a novel stereotactic coordinate system based upon mesial temporal anatomic landmarks to facilitate the planning and delineation of outcomes based on extent of ablation of mesial temporal structures. Methodology: The body of the hippocampus contains a natural axis, approximated by the interface of CA4 and the dentate gyrus. The uncal recess of the lateral ventricle acts as a landmark to characterize anterior-posterior extent. Several volumetric rotations are quantified for alignment with the hippocampal coordinate system. First, the brain volume is rotated to align with standard AC-PC space. Then, it is rotated through the angles the hippocampal-axis makes with the AC/PC-line, from both an axial and sagittal view. Results: Using this coordinate system, customized MATLAB software was developed to allow for intuitive standardization of targeting and interpretation. The angle between the AC/PC-line and the hippocampal-axis was found to be ~20-30° when viewed sagittally and of order ~0-10° when viewed axially. Implanted electrodes can then be identified from CT in this space, and laser tip position and burn geometry can be calculated based on the intraoperative and post-operative MRI. Conclusion: With the advent of stereotactic surgery for mesial temporal targets, a hippocampal stereotactic system is introduced which may facilitate operative planning, improve surgical outcomes, and standardize outcome assessment.
Software/Multimedia
73 pages ; 25 cm.
A number of recent studies have expressed optimism about the constant decrease in armed conflicts around the world. The prognosis for Africa does not reflect the same optimism. Poverty reduction, transparent and accountable governance and citizen satisfaction with the delivery of public goods and service have shown no sign of significant improvement. In this lecture, Victor Adetula examines the performance of Africa's regional organisations in ensuring peace and security on the continent. In doing this, he draws attention to the need for national and regional actors to pay attention to good governance and development as part of their efforts to operate effective collective security systems and conflict resolution mechanisms without ignoring the essence of the global context.
Green Library
Collection
A tide prediction and tide height control system for laboratory mesocosms
This archive contains materials related to a tide prediction system and laboratory aquarium tide height control system. It includes a set of tide prediction libraries meant to run on Arduino microcontrollers. The libraries are based on data generated by the National Ocean and Atmospheric Administration's National Ocean Service, and were compiled by David Flater for the open source program XTide. The data from XTide were then adapted to generate the individual libraries for a variety of sites around the US mainland, Alaska, Hawaii, Puerto Rico and the Virgin Islands. We also provide a set of R scripts to generate new libraries for additional NOAA tide station sites that are not included in this repository. See the folder "Generate_new_site_libraries" in the archive for the scripts and description of the library generation process. Diagrams and parts lists for the mechanical portion of the tide control rack are provided as well. R code and raw data for the plant growth analysis are provided as well.
Software/Multimedia
1 computer optical disc : sd., col. ; 4 3/4 in.
"As the united forces of Gotham's supervillains take control of the City, the Dark Knight unleashes the all new transformable Batmobile in the explosive finale to the Arkham trilogy."--Container.
Media & Microtext Center
Software/Multimedia
1 computer optical disc : sd., col. ; 4 3/4 in.
An episodic first-person shooter (FPS) crime drama game set in Miami and Los Angeles with criminal and police characters, including Miami detective Nick Mendoza, that may be played as a single player campaign or as a multiplayer game.
Media & Microtext Center

53. Bloodborne [2015]

Software/Multimedia
1 computer optical disc : sound, color ; 4 3/4 in. Digital: PlayStation 4; All region.
"Face your fears in this ancient city where danger, death and madness lurk around every corner, and uncover the city's darkest secrets in order to survive."--Container.
Media & Microtext Center
Collection
Software and data produced by Baker Research Group
This page provides data and code to document the referenced paper, which examines four methods by which ground motions can be selected for dynamic seismic response analyses of engineered systems when the underlying seismic hazard is quantified via ground motion simulation rather than empirical ground motion prediction equations. Even with simulation-based seismic hazard, a ground motion selection process is still required in order to extract a small number of time series from the much larger set developed as part of the hazard calculation. Four specific methods are presented for ground motion selection from simulation-based seismic hazard analyses. One of the four methods provides a ‘benchmark’ result (i.e. using all simulated ground motions), enabling the consistency of the other three more efficient selection methods to be addressed.
Collection
Stanford Research Data
Included in this supplement to Lau et al. (2016) is the R code used to explore controls on d238U and [U] in seawater (U model.R) (Figures 1 and S6). We also include the R code used to explore the links between the OMZ and the carbon cycle (Figures 4, S8). We make this code available without restriction for any purpose as long as the original paper is properly cited.
Collection
Stanford Research Data
Included in this supplement is the R code used to calculate Pliocene changes in EAIS mass and global sea level as function of temperature change based on the LR04 benthic stack using Eq.'s 1 and 2 of Winnick and Caves (2015). We make this code available without restriction for any purpose as long as the original paper is properly cited.
Software/Multimedia
1 computer disc : color, sound ; 4 3/4 inches
  • Graphic novel scenarios
  • Interactive exercises
  • Resources.
Disc container: Dating Matters® is a free, online course available to educators, school personnel, youth mentors, and others dedicated to improving teen health. Follow a school administrator throughout his day as he highlights what teen dating violence is and how to prevent it through graphic novel scenarios, interactive exercises, and information gathered from leading experts.
Media & Microtext Center
Software/Multimedia
1 online resource : color, sound
  • Graphic novel scenarios
  • Interactive exercises
  • Resources.
Dating Matters® is a free, online course available to educators, school personnel, youth mentors, and others dedicated to improving teen health. Follow a school administrator throughout his day as he highlights what teen dating violence is and how to prevent it through graphic novel scenarios, interactive exercises, and information gathered from leading experts.

59. FIFA 16. [2015]

Software/Multimedia
1 computer disc : sound, color ; 4 3/4 in. Sound: digital; optical.
"Play beautiful: innovation across the entire pitch. New ways to play. Compete at a higher level with FIFA trainer. FIFA ultimate team draft: an all-new way to play the most popular mode"--Container.
Media & Microtext Center
Software/Multimedia
1 computer disc : sound, color ; 4 3/4 in. Sound: digital; optical; Dolby Digital.
"Enter the fray as Class Zero. Engage enemies in bloody, action-packed battles. Customize your party with 14 unique characters. Experience a brutal tale of life and death in war"--Container.
Media & Microtext Center