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• Oxygen: An Element of Many Surprises
• What Are Stereoelectronic Effects, and How Can We Control Them?
• Structural, Spectroscopic, and Chemical Manifestations of Stereoelectronic Effects
• Models and Theoretical Studies of Stereoelectronic Effects
• Organic Chemistry through the Prism of SEs: Functional Groups with One Oxygen
• Organic Chemistry through the Prism of SEs: Functional Groups with Two Oxygens
• O2, O3, CO2: Simple but Surprising Molecules That Take Us beyond 2-Center, 2-Electron Bonds

"Although carbon is considered the central element of organic chemistry, the broader chemical world has one more star player-oxygen. Billions of years of evolution have filled your room with oxygen as countless cyanobacteria and plants work on changing our planet. Oxygen is everywhere-from geology to biology, from the Earth's crust to the ozone layer. This digital primer aims to analyze chemical reactivity through the prism of oxygen chemistry. The key to understanding this chemistry is the lone pairs of oxygen (i.e., the underutilized "idle" electrons that do not directly contribute to the Lewis structure of molecules). By highlighting the many roles of oxygen, we will illustrate how chemistry rises above the limitations of Lewis structures and how electrons stay neither idle nor "lone" even if they are in "lone pairs" when an oxygen atom is near a reaction center. This digital primer will introduce important types of chemical bonding that transcend undergraduate textbooks but that are likely to drive the development of new chemical reactions in the future."-- Provided by publisher

• PARAMAGNETIC COMPLEXES IN HIGHRESOLUTION NMR SPECTROSCOPY; PARAMAGNETIC COMPLEXES IN HIGHRESOLUTION NMR SPECTROSCOPY; Library of Congress Cataloging-in-Publication Data; CONTENTS; PREFACE; Chapter 1:APPLICATION OF NMR SPECTRA OFPARAMAGNETIC SYSTEMS FOR STRUCTURALSTUDIES OF ORGANIC LIGANDS; 1
• .1. Nature of Hyperfine Contact Coupling in Paramagnetic Complexes; 1
• .2. STUDY OF SPATIAL STRUCTURE OF ORGANIC COMPOUNDS; Chapter 2:METHOD OF PARAMAGNETIC ADDITIVES; 2
• .1. THEORY OF THE METHOD; 2
• .2. PARAMAGNETIC ADDITIVES OF IRON GROUP ELEMENTS; 2
• .3. LANTHANIDE PARAMAGNETIC ADDITIVES.

• 2
• .4. APPLICATION OF PARAMAGNETIC COMPLEXES FOR THE NMRSPECTRA ANALYSISChapter 3:APPLICATION OF COMPLEX FORMATION PROCESSIN STRUCTURAL ST; 3
• .1. SPATIAL STRUCTURE OF 1-VINYLIMIDAZOLE; 3
• .2. COMPLEXING ABILITY AND STRUCTURE OFSI-SUBSTITUTED SILATRANES; 3
• .3. STRUCTURE OF METHYL THIENYL KETONE OXIME STUDIEDBY PARAMAGNETIC ADDITIVES METHOD; 3
• .4. PECULIARITIES OF MOLECULAR STRUCTURE OF NICKELPARAMAGNETIC COMPLEXES WITH NITROXYL RADICALS; 3
• .5. PECULIARITIES OF INTRAMOLECULAR EXCHANGE ANDVALENCE TAUTOMERISM IN METAL SEMI-QUINOLATES; CONCLUSION; REFERENCES; Blank Page; INDEX.

The monograph covers theoretical aspects of the method based on the analysis of NMR spectra transformed by electron-nuclear or hyperfine coupling, and provides examples of its practical application for the solution of different tasks related to structure and intramolecular dynamics of multi-electron systems. The fundamentals of NMR theory in paramagnetic systems were formulated by Blombergen, McConnell, Solomon, Berkheyn and other researchers. However, wide application of HFC specifics for the solution of diverse chemical tasks was triggered later, after the development of a method for analysi.

"The Nobel Prize is science's highest award, as is the case with non-science fields too, and it is therefore arguably the most internationally recognized award in the world. This unique set of volumes focuses on summarizing the Nobel Prize within organic chemistry, as well as the specializations within this specialty. Any reader researching the history of the field of organic chemistry will be interested in this work. Furthermore, it serves as an outstanding resource for providing a better understanding of the circumstances that led to these amazing discoveries and what has happened as a result, in the years since"-- Provided by publisher

• Note continued: Study Problems
• Why We Synthesize Organic Compounds
• Synthetic Challenges: Total Synthesis
• Synthetic Challenges: Semisynthesis
• Synthetic Challenges: Biomimetic Synthesis
• Synthetic Challenges: Structural Revision or Confirmation
• Synthetic Challenges: Formal Synthesis
• Synthetic Challenges: Stereoselective Synthesis of Optically Pure Compounds
• Resolution of Enantiomers to Obtain Optically Pure Compounds
• Use of Chiral Pool Compounds for Synthesis of Optically Pure Natural Products
• Use of Chiral Reagents for Synthesis of Optically Pure Compounds
• Use of Chiral Substrate Control for Stereoselective Synthesis
• Use of Chiral Auxiliaries for Synthesis of Optically Pure Compounds
• Use of Chiral Catalysis for Synthesis of Optically Pure Compounds
• Use of Enzymes for Synthesis of Optically Pure Compounds: Biocatalysis
• Some Final Thoughts
• Study Problems.

• Machine generated contents note: The Unique Role of Carbon
• Distinguishing Primary Versus Secondary Metabolism
• Secondary Metabolites and Natural Products
• Natural Products in Organic Chemistry and Medicine
• The Organic Chemistry of Biosynthesis
• Goals and Structure of This Book
• Review of Functional Groups, Stereochemistry, and Conformational Analysis
• Prochiral Relationships: One Step from Chirality
• Prochiral it-Systems: "Two-Faced" Reaction Centers
• Diastereotopic Atoms and Groups: One Step from a Diasteroeomer
• Monosubstituted Cyclohexanes: Favoring Equatorial Positions
• Disubstituted Cyclohexanes: Equivalent and Nonequivalent Combinations
• Bicyclic Systems: Joining of Rings
• Heterocyclic Ring Systems: One Atom Makes All the Difference
• Bond Making and Breaking: Have Pair, Will Share; Need Two from You
• Bronsted Acid-Base Reactions: Proton Donors Gladly Accepted
• Acidity Trends: Why that Proton Is or Isn't Acidic
• Carbocations: Three Bonds to Carbon Can Be a Plus
• Radicals: Odd and Reactive
• Elimination Reactions: Introducing the Carbon-Carbon n-Bond
• Carbocations: Rearrangements and Fates
• Electrophilic Additions: n-Bonds as Nucleophilic Agents
• Nucleophilic Substitutions and Alkylations: Make or Break for C-X Bonds
• Nucleophilic Carbonyl Addition Reactions: C=O n-Bond under Attack
• Imine Formation: Making the Essential C=N Linkage
• Nucleophilic 1,4-(Conjugate) Addition Reactions: Remote Attack on Conjugated Carbonyls
• Nucleophilic Acyl Substitution Reactions: Turning One Acyl Compound into Another
• Looking Ahead
• Study Problems
• Enzymes: The Catalysts of Biological Organic Chemistry
• Cofactors: Enzyme Assistants in Bioorganic Reactions
• NADH/NADPH: Nature's Version of Sodium Borohydride for Carbonyl Reduction
• NAD+/NADP+: Nature's Version of PCC for Alcohol Oxidation
• FAD: Another Hydride Acceptor for Dehydrogenations
• Monooxygenases: Special Delivery of One 0 atom from 02
• Dioxygenases: Delivering Both 0 Atoms from 02
• Other Oxidations: Hydroquinone and Catechol Oxidations
• Amine Oxidations: From Imines to Carbonyl Compounds and Beyond
• PLP: Transamination and Decarboxylation of Amino Acids
• Other Important Decarboxylations: 13-Keto Acids, o- and p-Hydroxybenzoic Acids
• Thiamine Diphosphate (TPP) and Lipoic Acid: Decarboxylation and Acyl Transfer
• Biotin: The CO2 Carrier, Transport, and Transfer Agent
• SAM: A C1 Fragment for Methyl Groups
• DMAPP: An Allylic C, Fragment for Structure Building
• Other Essential Structural Fragments: Putting it All Together
• Looking Ahead
• Study Problems
• What Makes a Carbohydrate?
• Cyclic Hemiacetals and Anomers
• C-2 Epimers and Enediols[--]Simple Conversion of One Carbohydrate into Another
• Other Important Monosaccharides: Deoxy and Amino Sugars
• The Significance of the Anomeric Carbon: Glycoside Formation
• UDP-Sugars and Glycoside Formation: SN2 Chemistry at Work
• Organic Reactions in Carbohydrate Chemistry: Overview of Glucose Metabolism
• Glycolysis: A 10-Step Program
• What Happens to the Pyruvic Acid from Glycolysis
• The Citric Acid Cycle: Another 10-Step Program
• The Pentose Phosphate Pathway: Seven Alternative Steps to Some Familiar Intermediates
• The Big Picture
• Amino Acids: More Important Primary Metabolite Building Blocks for Biosynthesis
• Biosynthesis of Serine: A Good Place to Start
• Peptides and Proteins: A Very Brief Review
• Putting Proteins and Carbohydrates Together: Glycoproteins Versus Protein Glycosylation
• Looking Ahead
• Study Problems
• Classification of Terpenes: How Many Isoprene Units?
• The Mevalonic Acid Route to DMAPP and IPP
• The Deoxyxylulose Phosphate Route to IPP and DMAPP
• Hemiterpenes: Just One Isoprene Unit
• Monoterpenes (C10) and Isoprene Linkage: Heads, IPP Wins; Tails, DMAPP Loses
• Geranyl PP to Neryl PP via Linalyl PP: The Importance of Alkene Stereochemistry
• Some Acyclic Monoterpenes and Their Uses
• Mono- and Bicyclic Monoterpenes via Cationic Cyclizations and Wagner-Meerwein Shifts
• What's that Smell? Limonene Derivatives as Flavor and Fragrance Compounds
• Irregular Monoterpenes: If Not Head-to-Tail, then How?
• Iridoids: From Catnip to Alkaloids
• Sesquiterpenes (C15): Linking of Different Starter Units
• Some FPP Cyclizations in Sesquiterpene Biosynthesis
• Trichodiene and the Trichothecenes: How to Trace a Rearrangement Pathway
• Diterpenes (C20): Taking it to the Next Level of Molecular Complexity and Diversity
• Cyclic Diterpenes: From Baseball and Plant Hormones to Anticancer Drugs
• Sesterterpenes (C25): Less Common, More Complex
• Triterpenes and Steroids: Another Case of Irregular Linkage of Terpene Units
• Oxidosqualene and Steroid Biosynthesis: Cyclization to Lanosterol and Beyond
• Conversion of Lanosterol (C30) to Cholesterol (C27): Where Did the Carbons Go?
• Conversions of Cholesterol: Production of the Sex Hormones
• Dehydrocholesterol, Sunshine, and Vitamin D3 Biosynthesis
• Tetraterpenes and Carotenoids: Tail-to-Tail Linkage of C20 Units
• Looking Ahead
• Study Problems
• Fatty Acids: Multiples of Two Carbons, Saturated or Unsaturated
• Saturated Fatty Acid Biosynthesis: It All Starts with Acetyl-CoA
• Branched Fatty Acids: Different Routes and Different Results
• Mono- and Polyunsaturated Fatty Acids: Putting in the "Essential" Double Bonds
• Aerobic Versus Anaerobic Routes to Desaturation
• Further Desaturation of Fatty Acids: Triple Bonds and Rings
• Prostaglandins, Thromboxanes, and Leukotrienes: The Power of Oxygenated FAs
• Polyketide Biosynthesis: More Starter Units and Extender Units, but with a Twist
• Aromatic Polyketide Natural Products: Phenols and Related Structures
• Isotopic Labeling Studies: Biosynthetic Insights via 13C NMR
• Further Modification of Polyketides: Alkylations, Oxidations, Reductions, and Decarboxylations
• Other Oxidative Modifications of Aromatic Rings: Expansion or Cleavage Processes
• Oxidative Coupling of Phenols: Formation of Aryl-Aryl Bonds
• The Use of Other Starter Groups: From Cancer Drugs and Antibiotics to Poison Ivy
• More on Polyketide Synthase (PKS) Systems: Increasing Product Diversity
• Modular Type I PKS Complexes and Macrolide Antibiotics: Erythromycin Biosynthesis
• Genetic Manipulation of Modular PKS Systems: Rational Drug Modification
• Some Final PKS Products of Medicinal Importance
• Looking Ahead
• Study Problems
• What Is Shikimic Acid?
• Shikimic, Chorismic, and Prephenic Acids at the Heart of the Pathway
• The Claisen Rearrangement: Allyl Vinyl Ethers in a Chair
• Conversion of Chorismic Acid to Prephenic Acid
• Conversion of Prephenic Acid to Phenylalanine or Tyrosine
• More Uses for Chorismic Acid
• Shikimic Acid Pathway Products from Phenylalanine and Tyrosine: An Overview
• Phenylpropanoids: A Large Family of Phenyl C3 Compounds
• Phenylpropanoids: Reduction of Acids to Phenyl C3 Aldehydes and Alcohols
• Reduction of Phenyl C3 Alcohols to Phenylpropenes
• Lignans and Lignin: Oxidative Phenolic Coupling with a Twist
• Coniferyl Alcohol Oxidative Coupling: Allyl C-Radical + Allyl C-Radical
• Coniferyl Alcohol Oxidative Coupling: Ortho C-Radical + Allyl C-Radical
• Coniferyl Alcohol Oxidative Coupling: O-Radical + Allyl C-Radical
• Lignin: A Plant Polymer and Major Source of Carbon
• Podophyllotoxin Biosynthesis: Aryltetralin Lignans from the American Mayapple
• Cleavage of Cinnamic Acids to Phenyl Cl Compounds: Different Routes, Similar Outcomes
• Coumarins: Sweet-Smelling Benzopyrones
• Mixed Products: Combining the Shikimate, Polyketide, and Terpenoid Pathways
• Kavalactones: Natural Sedatives from the South Pacific
• Flavonoids: Structurally Diverse Plant Polyphenolics
• The Chalcone-to-Flavanone-to-Flavone Sequence: Formation of Apigenin
• The Flavanone-to-Dihydroflavonol-to-Anthocyanin Sequence: Formation of Pelargonidin
• The Flavanone-to-Isoflavanone-to-Isoflavone Sequence: Formation of Genistein
• Isoflavanoid Structural Modifications: Production of Antimicrobial Phytoalexins
• Rotenoids: Fish Poisons from Isoflavones
• Looking Ahead
• Study Problems
• Alkaloid Structure: The Importance of N-Heterocycles
• Alkaloids Not Derived from Amino Acids: Amination Reactions, Poisons, and Venoms
• Amino Acids and Mannich Reactions: Important Keys to Alkaloid Biosynthesis
• Alkaloids from Ornithine: Tropanes via the Mannich Reaction in Action
• Pyrrolizidine Alkaloids: Poison Plants and Insect Defense
• Piperidine-Type Alkaloids Derived from Lysine
• Quinolizidine Alkaloids: Livestock Poisons from Cadaverine
• Alkaloids from Phenylalanine: From Neurotransmitters to Decongestants and Narcotics
• Alkaloids from Tyrosine: The Pictet-Spengler Reaction in Alkaloid Biosynthesis
• (S)-Reticuline: A Versatile Pictet-Spengler-Derived Benzyltetrahydroisoquinoline
• Oxidative Coupling in Alkaloid Biosynthesis: Biosynthesis of Corytuberine and Morphine
• The Morphine Rule
• Alkaloids from Tryptophan: Adventures in Indole Alkaloid Structural Complexity
• Pictet-Spengler-Type Reactions of Tryptamine: p-Carbolines and Indole Terpene Alkaloids
• Alkaloids from Nicotinic Acid: Toxic Addictive Derivatives of a Common Nutrient
• Alkaloids from Anthranilic Acid: From Tryptophan to Quinolines and Acridines
• Alkaloids from Histidine: From Simple Amides to Glaucoma Drugs
• Purine Alkaloids: Addictive Stimulants in our Coffee, Tea, and Chocolate
• Cyclic and Macrocyclic Peptides: From Sweeteners to Antibiotics and Beyond
• Penicillins, Cephalosporins, and Carbapenums: The Essential p-Lactam Antibiotics
• A Final Look Ahead.

Over the last three decades, the interface between chemistry and biology has grown increasingly dynamic, resulting in the rapid expansion of communication and collaboration amongst research scientists, faculty and students in the fields of chemistry, biochemistry, biology, bioengineering, and beyond. This is due in part to society's growing demand for scientists, engineers and practitioners who can bring a more interdisciplinary approach to their work. For this reason, new elective courses at the undergraduate level that address topics crossing the traditional boundaries of chemistry and biology are increasingly necessary, as are courses that can provide traditional chemistry students with additional insight into the fundamental role that chemistry plays in the function and evolution of biological systems. Morrow's book builds on the foundation of a one-year introductory course in organic chemistry, focusing on familiar organic chemical processes associated with the biosynthesis of primary and secondary metabolites, with special emphasis on the latter group. Ultimately, it brings to undergraduate science majors the opportunity to develop a deeper understanding of fundamental mechanistic organic chemistry within a meaningful biological context that goes far beyond the usual boxed essays or supplemental problems that increasingly crowd the margins of many introductory organic chemistry textbooks. The book offers ideal support for courses in chemistry, biochemistry, biology, pre-medicine and bioengineering programs.
(source: Nielsen Book Data)

• Frontmatter
• Preface
• Contents
• 1. Flash Point
• 2. Autoignition
• 3. Flammability Limit
• 4. Heat of Combustion
• 5. Polymer Flammability
• Problems
• Answers to Problems
• List of Symbols
• Appendix
• References
• Index

The combustion properties of organic materials are used to assess their safety specifications. This knowledge is necessary to avoid potentially disastrous fires. The experimental determination of the combustion properties of a new organic compound is laborious and sometimes even impossible. This book describes methods for the determination and prediction of the combustion properties of organic compounds, along with some examples and exercises.
(source: Nielsen Book Data)

• 1. Introduction
• 2. Introducing High-Resolution NMR
• 3. Practical Aspects of High-Resolution NMR
• 4. One-Dimensional Techniques
• 5. Introducing Two-Dimensional and Pulsed Field Gradient NMR
• 6. Correlations Through the Chemical Bond I: Homonuclear Shift Correlation
• 7. Correlations Through the Chemical Bond II: Heteronuclear Shift Correlation
• 8. Separating Shifts and Couplings: J-Resolved and Pure Shift Spectroscopy
• 9. Correlations Through Space: The Nuclear Overhauser Effect
• 10. Diffusion NMR Spectroscopy
• 11. Protein-Ligand Screening by NMR
• 12. Experimental Methods
• 13. Structure Elucidation and Spectrum Assignment.
• (source: Nielsen Book Data)

High-Resolution NMR Techniques in Organic Chemistry, Third Edition describes the most important NMR spectroscopy techniques for the structure elucidation of organic molecules and the investigation of their behaviour in solution. Appropriate for advanced undergraduate and graduate students, research chemists and NMR facility managers, this thorough revision covers practical aspects of NMR techniques and instrumentation, data collection, and spectrum interpretation. It describes all major classes of one- and two-dimensional NMR experiments including homonuclear and heteronuclear correlations, the nuclear Overhauser effect, diffusion measurements, and techniques for studying protein-ligand interactions. A trusted authority on this critical expertise, High-Resolution NMR Techniques in Organic Chemistry, Third Edition is an essential resource for every chemist and NMR spectroscopist.
(source: Nielsen Book Data)

• Students' Attention on Curved Arrows While Evaluating the Plausibility of an Organic Mechanistic Step--Supporting Spatial Thinking in Organic Chemistry Through Augmented Reality - An Explorative Interview Study--Representational Competence Under the Magnifying Glass - The Interplay Between Student Reasoning Skills, Conceptual Understanding, and the Nature of Representation--Fostering Causal Mechanistic Reasoning as a Means of Modelling in Organic Chemistry--Students' Reasoning in Chemistry Arguments and Designing Resources Using Constructive Alignment--From Free Association to Goal-directed Problem-solving - Network Analysis of Students' Use of Chemical Concepts in Mechanistic Reasoning--Epistemic Stances in Action - Students' Reasoning Process While Reflecting About Alternative Reaction Pathways in Organic Chemistry--How Do Students Reason When They Have to Describe the "What" and "Why" of a Given Reaction Mechanism?--In-the-moment Learning of Organic Chemistry During Interactive Lectures Through the Lens of Practical Epistemology Analysis--Flipped Classrooms in Organic Chemistry - A Closer Look at Student Reasoning Through Discourse Analysis of a Group Activity--Systemic Assessment Questions as a Means of Assessment in Organic Chemistry--Variations in the Teaching of Resonance - An Exploration of Organic Chemistry Instructors' Enacted Pedagogical Content Knowledge--Investigation of Students' Conceptual Understanding in Organic Chemistry Through Systemic Synthesis Questions--Disciplining Perception Spatial Thinking in Organic Chemistry Through Embodied Actions--Building Bridges Between Tasks and Flasks - Design of a Coherent Experiment-supported Learning Environment for Deep Reasoning in Organic Chemistry--Assessment of Assessment in Organic Chemistry - Review and Analysis of Predominant Problem Types Related to Reactions and Mechanisms--Developing Machine Learning Models for Automated Analysis of Organic Chemistry Students' Written Descriptions of Organic Reaction Mechanisms--Deveopment of a Generalizable Framework for Machine Learning-based Evaluation of Written Explanations of Reaction Mechanisms from the Post-secondary Organic Chemistry Curriculum--The Central Importance of Assessing "Doing Science" to Research and Instruction.
• (source: Nielsen Book Data)

Reasoning about structure-reactivity and chemical processes is a key competence in chemistry. Especially in organic chemistry, students experience difficulty appropriately interpreting organic representations and reasoning about the underlying causality of organic mechanisms. As organic chemistry is often a bottleneck for students' success in their career, compiling and distilling the insights from recent research in the field will help inform future instruction and the empowerment of chemistry students worldwide. This book brings together leading research groups to highlight recent advances in chemistry education research with a focus on the characterization of students' reasoning and their representational competencies, as well as the impact of instructional and assessment practices in organic chemistry. Written by leaders in the field, this title is ideal for chemistry education researchers, instructors and practitioners, and graduate students in chemistry education.
(source: Nielsen Book Data)

• Structure and physical properties- inductive and mesomeric effects
• basic stereochemistry
• reaction mechanisms - basic principles
• organic acids and bases
• halogen compounds
• alcohols, phenols and ethers
• aldehydes and ketones
• carboxylic acids and their derivatives
• alkenes and alkynes
• aromatic compounds
• amines, amino acids and diazonium salts
• free radical reactions
• guided route and short answer questions
• comments and outline answers to self-test questions.
• (source: Nielsen Book Data)

This book covers the first year of undergraduate courses in organic chemistry. Each chapter provides notes followed by examples showing how to approach all the different problems which occur at this level. Each chapter concludes with questions taken from examination papers. The author also wrote "Ionic Organic Mechanisms".
(source: Nielsen Book Data)

• 1 UV/Vis Spectroscopy 1.1 Theoretical Introduction 1.2 Sample Preparation and Measurement of Spectra 1.3 Chromophores 1.4 Applications of UV/Vis Spectroscopy 1.5 Derivative Spectroscopy 1.6 Chiroptical Methods
• 2 Infrared and Raman Spectra 2.1 Introduction 2.2 Basic Principles 2.3 Infrared Spectrometer 2.4 Sample Preparation 2.5 Infrared Spectrum 2.6 Characteristic Absorptions: An Overview 2.7 Infrared Absorptions of Single Bonds with Hydrogen 2.8 Infrared Absorptions of Triple Bonds and Cumulated Double Bonds 2.9 Infrared Absorptions of Double Bonds C=O, C=N, N=N, and N=O 2.10 Infrared Absorption of Aromatic Compounds 2.11 Infrared Absorption in the Fingerprint Range 2.12 Examples of Infrared Spectra 2.13 Information Technology Assisted Spectroscopy 2.14 Quantitative Infrared Spectroscopy 2.15 Raman Spectroscopy
• 3 Nuclear Magnetic Resonance Spectroscopy 3.1 Physical Principles 3.2 NMR Spectra and Molecular Structure 3.3 1H NMR Spectroscopy 3.4 13C NMR Spectroscopy 3.5 Combination of 1H and 13C NMR Spectroscopy 3.6 NMR of other Nuclei
• 4 Mass Spectrometry 4.1 Introduction 4.2 General Aspects of Mass Spectrometry 4.3 Instrumental Aspects 4.4 Interpretation of Spectra and Structural Elucidation 4.5 Sample Preparation 4.6 Artifacts 4.7 Tables to the Mass Spectrometry
• 5 Handling of Spectra and Analytical Data: Practical Examples 5.1 Introduction 5.2 Characterization of Compounds 5.3 Structure Elucidation of Allegedly Known Compounds and of Products Arising from Syntheses 5.4 Structure Elucidation of COmpletely Unknown Compounds.
• (source: Nielsen Book Data)

Boost your knowledge of modern spectroscopic methods! This reference work provides you with essential knowledge for the application of modern spectroscopic methods in organic chemistry. All methods are explained based on typical practical examples, theoretical aspects, and applications. The following spectroscopic methods are explained and examples are given: UV/Vis Spectroscopy Infrared (IR) and Raman Spectroscopy Nuclear Magnetic Resonance Spectroscopy (NMR) Mass Spectrometry (MS) The textbook has been a standard reference for decades. As it conveys necessary knowledge for examinations at all universities it is compulsory reading for every organic chemistry student!.
(source: Nielsen Book Data)

• Chapter 1 Bond-Line Drawings 1 1.1 How to Read Bond-Line Drawings 1 1.2 How to Draw Bond-Line Drawings 4 1.3 Mistakes to Avoid 6 1.4 More Exercises 6 1.5 Identifying Formal Charges 8 1.6 Finding Lone Pairs that are Not Drawn 11 Chapter 2 Resonance 15 2.1 What is Resonance? 15 2.2 Curved Arrows: The Tools for Drawing Resonance Structures 16 2.3 The Two Commandments 17 2.4 Drawing Good Arrows 20 2.5 Formal Charges in Resonance Structures 22 2.6 Drawing Resonance Structures-Step by Step 25 2.7 Drawing Resonance Structures-by Recognizing Patterns 29 2.8 Assessing the Relative Importance of Resonance Structures 36 Chapter 3 Acid-Base Reactions 41 3.1 Factor 1-What Atom is the Charge On? 41 3.2 Factor 2-Resonance 44 3.3 Factor 3-Induction 47 3.4 Factor 4-Orbitals 49 3.5 Ranking the Four Factors 50 3.6 Other Factors 53 3.7 Quantitative Measurement (pKa Values) 54 3.8 Predicting the Position of Equilibrium 54 3.9 Showing a Mechanism 55 Chapter 4 Geometry 57 4.1 Orbitals and Hybridization States 57 4.2 Geometry 60 4.3 Lone Pairs 62 Chapter 5 Nomenclature 64 5.1 Functional Group 65 5.2 Unsaturation 66 5.3 Naming the Parent Chain 67 5.4 Naming Substituents 70 5.5 Stereoisomerism 72 5.6 Numbering 74 5.7 Common Names 78 5.8 Going from a Name to a Structure 79 Chapter 6 Conformations 80 6.1 How to Draw a Newman Projection 80 6.2 Ranking the Stability of Newman Projections 84 6.3 Drawing Chair Conformations 86 6.4 Placing Groups on the Chair 90 6.5 Ring Flipping 93 6.6 Comparing the Stability of Chairs 99 6.7 Don't Be Confused by the Nomenclature 102 Chapter 7 Configurations 103 7.1 Locating Chiral Centers 103 7.2 Determining the Configuration of a Chiral Center 106 7.3 Nomenclature 113 7.4 Drawing Enantiomers 116 7.5 Diastereomers 120 7.6 Meso Compounds 121 7.7 Drawing Fischer Projections 123 7.8 Optical Activity 127 Chapter 8 Mechanisms 129 8.1 Introduction to Mechanisms 129 8.2 Nucleophiles and Electrophiles 129 8.3 Basicity vs. Nucleophilicity 131 8.4 Arrow-Pushing Patterns for Ionic Mechanisms 133 8.5 Carbocation Rearrangements 138 8.6 Information Contained in a Mechanism 142 Chapter 9 Substitution Reactions 145 9.1 The Mechanisms 145 9.2 Factor 1-The Electrophile (Substrate) 147 9.3 Factor 2-The Nucleophile 149 9.4 Factor 3-The Leaving Group 151 9.5 Factor 4-The Solvent 153 9.6 Using All Four Factors 155 9.7 Substitution Reactions Teach Us Some Important Lessons 156 Chapter 10 Elimination Reactions 157 10.1 The E2 Mechanism 157 10.2 The Regiochemical Outcome of an E2 Reaction 158 10.3 The Stereochemical Outcome of an E2 Reaction 159 10.4 The E1 Mechanism 162 10.5 The Regiochemical Outcome of an E1 Reaction 163 10.6 The Stereochemical Outcome of an E1 Reaction 164 10.7 Substitution vs. Elimination 164 10.8 Determining the Function of the Reagent 165 10.9 Identifying the Mechanism(s) 167 10.10 Predicting the Products 169 Chapter 11 Addition Reactions 172 11.1 Terminology Describing Regiochemistry 172 11.2 Terminology Describing Stereochemistry 174 11.3 Adding H and H 180 11.4 Adding H and X, Markovnikov 183 11.5 Adding H and Br, Anti-Markovnikov 188 11.6 Adding H and OH, Markovnikov 192 11.7 Adding H and OH, Anti-Markovnikov 194 11.8 Synthesis Techniques 198 11.9 Adding Br and Br
• Adding Br and OH 204 11.10 Adding OH and OH, Anti 209 11.11 Adding OH and OH, syn 211 11.12 Oxidative Cleavage of an Alkene 213 Summary of Reactions 214 Chapter 12 Alkynes 216 12.1 Structure and Properties of Alkynes 216 12.2 Preparation of Alkynes 218 12.3 Alkylation of Terminal Alkynes 219 12.4 Reduction of Alkynes 221 12.5 Hydration of Alkynes 224 12.6 Keto-Enol Tautomerization 227 12.7 Ozonolysis of Alkynes 232 Chapter 13 Alcohols 234 13.1 Naming and Designating Alcohols 234 13.2 Predicting Solubility of Alcohols 235 13.3 Predicting Relative Acidity of Alcohols 237 13.4 Preparing Alcohols: A Review 239 13.5 Preparing Alcohols via Reduction 240 13.6 Preparing Alcohols via Grignard Reactions 246 13.7 Summary of Methods for Preparing Alcohols 249 13.8 Reactions of Alcohols: Substitution and Elimination 250 13.9 Reactions of Alcohols: Oxidation 253 13.10 Converting an Alcohol into an Ether 255 Chapter 14 Ethers and Epoxides 257 14.1 Introduction to Ethers 257 14.2 Preparation of Ethers 259 14.3 Reactions of Ethers 261 14.4 Preparation of Epoxides 262 14.5 Ring-Opening Reactions of Epoxides 264 Chapter 15 Synthesis 270 15.1 One-Step Syntheses 271 15.2 Multistep Syntheses 283 15.3 Retrosynthetic Analysis 284 15.4 Creating Your Own Problems 285 Detailed Solutions 287 Index 381.
• (source: Nielsen Book Data)

Organic chemistry can be a challenging subject. Most students view organic chemistry as a subject requiring hours upon hours of memorization. Author David Klein's Second Language books prove this is not true-organic chemistry is one continuous story that actually makes sense if you pay attention. Offering a unique skill-building approach, these market-leading books teach students how to ask the right questions to solve problems, study more efficiently to avoid wasting time, and learn to speak the language of organic chemistry. Covering the initial half of the course, Organic Chemistry as a Second Language: First Semester Topics reviews critical principles and explains their relevance to the rest of the course. Each section provides hands-on exercises and step-by-step explanations to help students fully comprehend classroom lectures and textbook content. Now in its fifth edition, this valuable study resource covers the characteristics of molecules, the nature of atomic bonds, the relationships between different types of molecules, drawing and naming molecules, and essential molecular reactions.
(source: Nielsen Book Data)

• Chapter 1 Aromaticity 1 1.1 Introduction to Aromatic Compounds 1 1.2 Nomenclature of Aromatic Compounds 2 1.3 Criteria for Aromaticity 6 1.4 Lone Pairs 9
• Chapter 2 IR Spectroscopy 11 2.1 Vibrational Excitation 11 2.2 IR Spectra 13 2.3 Wavenumber 13 2.4 Signal Intensity 18 2.5 Signal Shape 19 2.6 Analyzing an IR Spectrum 26
• Chapter 3 NMR Spectroscopy 33 3.1 Chemical Equivalence 33 3.2 Chemical Shift (Benchmark Values) 36 3.3 Integration 41 3.4 Multiplicity 44 3.5 Pattern Recognition 46 3.6 Complex Splitting 48 3.7 No Splitting 49 3.8 Hydrogen Deficiency Index (Degrees of Unsaturation) 50 3.9 Analyzing a Proton NMR Spectrum 53 3.10 13C NMR Spectroscopy 57
• Chapter 4 Electrophilic Aromatic Substitution 60 4.1 Halogenation and the Role of Lewis Acids 61 4.2 Nitration 65 4.3 Friedel-Crafts Alkylation and Acylation 67 4.4 Sulfonation 74 4.5 Activation and Deactivation 78 4.6 Directing Effects 80 4.7 Identifying Activators and Deactivators 89 4.8 Predicting and Exploiting Steric Effects 99 4.9 Synthesis Strategies 106
• Chapter 5 Nucleophilic Aromatic Substitution 112 5.1 Criteria for Nucleophilic Aromatic Substitution 112 5.2 SNAr Mechanism 114 5.3 Elimination-Addition 120 5.4 Mechanism Strategies 125
• Chapter 6 Ketones and Aldehydes 127 6.1 Preparation of Ketones and Aldehydes 127 6.2 Stability and Reactivity of C===O Bonds 130 6.3 H-Nucleophiles 132 6.4 O-Nucleophiles 137 6.5 S-Nucleophiles 147 6.6 N-Nucleophiles 149 6.7 C-Nucleophiles 157 6.8 Exceptions to the Rule 166 6.9 How to Approach Synthesis Problems 170
• Chapter 7 Carboxylic Acid Derivatives 176 7.1 Reactivity of Carboxylic Acid Derivatives 176 7.2 General Rules 177 7.3 Acid Halides 181 7.4 Acid Anhydrides 189 7.5 Esters 191 7.6 Amides and Nitriles 200 7.7 Synthesis Problems 209
• Chapter 8 Enols and Enolates 217 8.1 Alpha Protons 217 8.2 Keto-Enol Tautomerism 219 8.3 Reactions Involving Enols 223 8.4 Making Enolates 226 8.5 Haloform Reaction 229 8.6 Alkylation of Enolates 232 8.7 Aldol Reactions 236 8.8 Claisen Condensation 242 8.9 Decarboxylation 249 8.10 Michael Reactions 256
• Chapter 9 Amines 263 9.1 Nucleophilicity and Basicity of Amines 263 9.2 Preparation of Amines Through SN2 Reactions 265 9.3 Preparation of Amines Through Reductive Amination 268 9.4 Acylation of Amines 273 9.5 Reactions of Amines with Nitrous Acid 276 9.6 Aromatic Diazonium Salts 279
• Chapter 10 Diels-Alder Reactions 282 10.1 Introduction and Mechanism 282 10.2 The Dienophile 285 10.3 The Diene 286 10.4 Other Pericyclic Reactions 292 Detailed Solutions S-1 Index I-1.
• (source: Nielsen Book Data)

Organic chemistry can be a challenging subject. Most students view organic chemistry as a subject requiring hours upon hours of memorization. Author David Klein's Second Language books prove this is not true-organic chemistry is one continuous story that actually makes sense if you pay attention. Offering a unique skill-building approach, these market-leading books teach students how to ask the right questions to solve problems, study more efficiently to avoid wasting time, and learn to speak the language of organic chemistry. The fifth edition of Organic Chemistry as a Second Language: Second Semester Topics builds upon the principles previously explored in first half of the course-delving deeper into molecular mechanisms, reactions, and analytical techniques. Hands-on exercises and thoroughly-explained solutions further reinforce student comprehension of chemical concepts and organic principles. An indispensable supplement to the primary text, this resource covers aromatic compounds, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, nucleophilic and electrophilic aromatic substitution, ketones and aldehydes, carboxylic acid derivatives, and much more.
(source: Nielsen Book Data)

• 1. Introduction to Aromatic Fluorination
• 2. Halex Chemistry
• 3. The Balz-Schiemann Reaction and Related Chemistry
• 4. Other Aromatic Fluorination Methodologies
• 5. Trifluoromethylaromatics
• 6. Trifluoromethylthioaromatics and Trifluoromethylsulfonylaromatics
• 7. Other Aromatic Ring Substituents
• 8. Industrial Aspects of Aromatic Fluorine Chemistry.
• (source: Nielsen Book Data)

Academia and industry join forces in Aromatic Fluorination, as an expert from each domain contributes to this new text on fluorination of carbocyclic and heterocyclic rings. The book begins with a discussion of fluorine's unique combination of properties, including size, electronic effects, and hydrophobicity, as well as the historical development of its product applications. It explains methods for introducing fluorine into an aromatic ring, focusing on nucleophilic fluorine transfer reactions. The role of catalysts, solvents, and other variables are examined, and the scope and limitations of the methods are discussed. Of particular interest to those working in non-specialist laboratories, Aromatic Fluorination includes detailed descriptions of the new electrophilic routes to fluoroaromatics, in addition to traditional routes and alternative methods involving radical chemistry. Because one of the most important fluorine-containing substituent is CF3, the book explains routes to benzotrifluorides (ArCF3), including traditional industrial methods and modern alternatives employing C-1 halofluorocarbons and other fluoroaliphatics. An alternative to CF3 is CF3S, and several methods of synthesizing aromatic CF3S-containing molecules are described. Since the successful development and diverse applications of aromatic fluorine compounds have led to the search for new compounds and novel substituents, the incorporation of other substituents is also explored. Aromatic Fluorination concludes with discussion of the factors responsible for the successful development of pharmaceutical, agrochemical and liquid crystal applications and the potential for applications in high-performance polymers and other areas. This section also describes in detail important industrial aromatic fluorination processes and the relative merits of different process technologies and their costs.
(source: Nielsen Book Data)

• chapter 1 Introduction / Andrew M. Harned
• chapter 2 Alcohols and Phenols as Hydrogen Bonding Catalysts / Yunus Emre Türkmen
• chapter 3 Phosphoric Acid Catalysis / Jia-Hui Tay
• chapter 4 Halogen Bond Catalysis
• An Emerging Paradigm in Organocatalysis / Choon-Hong Tan
• chapter 5 Catalysis with Selenium and Sulfur / Yi An Cheng
• chapter 6 Use of Phosphine Oxides as Catalysts and Precatalysts / Zhiqi Lao
• chapter 7 N-Heterocyclic Carbene Catalysis
• Homoenolate and Enolate Reactivity / Xinqiang Fang
• chapter 8 Other Nonnitrogenous Organocatalysts / Andrew M. Harned.

Since the 1990s the synthetic community has shown a growing interest in the development of catalytic reactions that employ entirely organic catalysts - so-called 'organocatalysts'. With the current emphasis on green chemistry throughout the chemical industry, organocatalysis has become indispensible. In spite of this growth and recognition, there can be a misconception that organocatalysts are only based on nitrogen-containing functional groups (amines, ureas, and quaternary ammonium salts, for example), and are only useful for asymmetric reactions. Nonnitrogenous Organocatalysis shows that the umbrella of organocatalysis covers other main group elements besides nitrogen, and the coverage is not just limited to asymmetric methods. Many of the catalysts and mechanisms discussed may not have a viable asymmetric variant or cannot be rendered asymmetric at all. This does not make them any less useful, as illustrated in this book.
(source: Nielsen Book Data)

• 1. The Di- -Methane Rearrangement
• 2. Synthetic Aspects of the Oxadi- -Methane Rearrangement
• 3. The Photochemistry of Carbenium Ions and Related Species
• 4. Photoinduced Hydrogen Atom Abstraction by Carbonyl Compounds
• 5. Selected Topics in the Matrix Photochemistry of Nitrenes, Carbenes, and Excited THplet States.
• (source: Nielsen Book Data)

Organic photochemistry is the science arising from the application of photochemicalmethods to organic chemistry and organic chemical methods to photochemistry. It is aninterdisciplinary frontier.Intense activity in organic photochemistry in the last decade has produced so vast anaccumulation of factual knowledge that chemists in general have viewed it with awe.Even those chemists engaged in the study of organic photochemistry will find the rate ofdevelopment in the field perplexing to a high degree. This series originated to fill theneed for a critical summary of this vigorously expanding field with the purpose ofdrawing together seemingly unrelated facts, summarizing progress, and clarifyingproblems.Volume 11 continues to fulfill the original, essential role of this unique series byproviding a convenient review of the structural aspects of organic photochemistry. Aswith earlier volumes, this new book offers the research findings of distinguishedauthorities. It stresses timely aspects of organic photochemistry-previously scatteredthroughout the large body of literature-for which necessary critical review has beenlacking.This volume of the series emphasizes the mechanistic details of the di-n:-methanerearrangement . .. the synthetic aspects of the oxadi-n:-methane reaction ... thephotochemistry of carbenium ions and related species .. . photoinduced hydrogen atomabstraction by carbonyl compounds ... and matrix photochemistry of nitrenes, carbenes, and excited triplet states. Complete with numerous illustrations and bibliographiccitations of the literature, this book explores these important processes to the advantageof organic chemists, as an aid to research and as a source for supplementary knowledgeon particular topics .
(source: Nielsen Book Data)

• Chapter 1
• General Concepts for Covalent Bonding and Constructing Lewis Structures for Organic Molecules
• Chapter 2
• Guideline for Writing Organic Molecule Isomers and Determining Number of Rings Plus Pi-Bonds
• Chapter 3
• Guideline for Complete Analysis for Central Atoms and Molecules: Bonding/Hybridization/Geometry/Polarity
• Chapter 4
• Notation in Organic Chemistry: Guide to Writing and Using Condensed Formulas and Line Drawings
• Chapter 5
• Summary Guidelines for Organic Nomenclature
• Chapter 6
• Guidelines for Analysis of Intermolecular Forces for Organic Molecules
• Chapter 7
• Alkane and Cycloalkane Conformations
• Chapter 8
• Summary Guide to Thermodynamic Concepts for Organic Chemistry
• Chapter 9
• Guide to Kinetics and Reaction Mechanisms
• Chapter 10
• Review of Acid/Base Concepts for Organic Chemistry
• Chapter 11
• Electrophiles and Nucleophiles in Organic Reaction Mechanisms
• Chapter 12
• Conceptual Guide to Mechanisms in Organic Chemistry
• Chapter 13
• Guide to Stereochemistry Concepts and Analysis of Reaction
• Stereochemistry as Applied to Electrophilic Addition
• Chapter 14
• A Process for Calculation of Product Distribution Through Relative Rate Analysis: Examples for Free Radical Halogenation
• Chapter 15
• Process to Identify and Solve the Reactions for Organic I
• Chapter 16
• Electrophilic Addition and Addition/Elimination to
• Conjugated Double Bond and Aromatic Systems
• Chapter 17
• Oxidation/Reduction Relationships for Carbonyl Carbon
• Chapter 18
• A Complete System for Organizing, Identifying, and Solving Carbonyl Reactions: Nucleophilic Addition and Addition/Elimination
• Chapter 19
• A Brief Guideline for Applying Fundamental Concepts in NMR Spectroscopy
• Organic I Practice Exams
• Exams 1, 2
• Organic Structure-- Molecular Geometry-- Hybridization
• Exams 3, 4, 5
• Alkanes/Cycloalkanes: Nomenclature, Properties, Conformations, Chirality, and Stereochemistry
• Exams 6, 7, 8
• Chirality and Diastereomers-- Acid/Base Chemistry-- Alkene Properties/Stereochemistry-- Alkene and Alcohol Nomenclature
• Exams 9, 10, 11
• Kinetics and Thermodynamics-- Mechanism Concepts-- Alkene Reactions-- Electrophilic Addition to Alkenes
• Exams 12, 13, 14
• Alkyl Halides: Free Radical Mechanisms-- SN1 and SN2
• Exams 15, 16, 17
• Alkyl Halides and Alcohols: Reactions and Properties-- SN1, SN2, E1, E2
• Organic II Practice Exams
• Exams 18, 19, 20
• Reactions and Nomenclature of Alkynes-- Electrophilic Addition to Conjugated Systems-- Diels-Alder-- Aromatic Molecules: Properties, Reactions, Electrophilic Aromatic Substitution
• Exams 21, 22
• Organometallic Reactions-- Redox Reactions of Alcohols-- Epoxides, Ethers-- Nucleophilic Aromatic Substitution
• Exams 23, 24
• Carbonyl Chemistry-- Aldehydes, Ketones-- Carboxylic Acid Derivatives-- Nucleophilic Addition and Addition/Elimination
• Exams 25, 26, 27
• Enol and Enolate Anion Reactions of Carbonyls-- Aldol and Claisen Condensations-- , -Unsaturated Aldehydes-- -Ketoesters-- Decarboxylation-- Amine Chemistry
• Multiple Choice Exams
• Organic I: Multiple Choice Exam 1
• Kinetics and Thermodynamics-- Alkanes/Cycloalkanes: Nomenclature, Properties, Conformations, Chirality, and Stereochemistry
• Organic I: Multiple Choice Exam 2
• Stereochemistry-- Alkene Reactions-- Alkyl Halide and Alcohol Reactions: SN1, SN2, E1, E2, Radicals
• Organic II: Multiple Choice Exam 1
• Reactions and Nomenclature of Alkynes-- Electrophilic Addition to Conjugated Systems-- Diels-Alder-- Aromatic Molecules: Properties, Reactions, Electrophilic Aromatic Substitution
• Organic II: Multiple Choice Exam 2
• Short Comprehensive Exam Written in the Style of a Standardized Exam.
• (source: Nielsen Book Data)

• Guide to Covalent Bonding and Constructing Lewis Structures for Organic Molecules. Summary Guide for Thermodynamics in Organic Chemistry. Guide to Kinetics and Reaction Mechanisms. Guideline for Complete Analysis of Organic Molecules: Bonding/Hybridization and Geometry/Polarity. Notation in Organic Chemistry: Guide to Writing Structures and Formulas. Review Guidelines for Analysis of Intermolecular Forces in Organic Chemistry. Electrophiles and Nucleophiles in Organic Reaction Mechanisms. Conceptual Guide to Mechanisms in Organic Chemistry. Flow Diagram and Collection of Summaries for Reactions in Organic Chemistry I. Review of Acid/Base Concepts for Organic Chemistry. Electrophilic Addition and Addition/Elimination to Conjugated Double Bond and Aromatic Systems. Reaction at Carbonyl Carbons: Nucleophilic Addition and Addition/Elimination. Oxidation/Reduction Relationships for Carbonyl Carbon. Guideline for Writing Organic Molecule Isomers and Determining Number of Rings plus Pi--Bonds. Summary Guidelines for Organic Nomenclature. Product Isomer Percent and Ratio Calculation for Free Radical Halogenation through Rate Analysis. Practice Problems Include the Following Chapters: ORGANIC CHEMISTRY I CURRICULUM: General thermodynamic and kinetic concepts
• bonding and geometry
• corresponds to Chapter 1--5, 10, and 14. General concepts for alkanes, cycloalkanes
• nomenclature
• corresponds to Chapter 1, 4, and 15. Alcohols, alkyl halides
• concepts of reaction mechanisms
• SN1, SN2
• free radical halogenation
• corresponds to Chapter 7, 8, 9, 10, 16. Alkenes
• advanced concepts of mechanisms
• E1, E2
• electrophilic addition
• corresponds to Chapter 8, 9. Alkenes
• chirality and stereoisomers
• corresponds to Chapter 8, 9. ORGANIC CHEMISTRY II CURRICULUM: Alkynes
• conjugated systems
• cycloadditions
• corresponds to Chapter 8, 10, 11. Aromatics
• electrophilic aromatic substitution
• corresponds to Chapter 11. Diols, ethers, epoxides, organometallics
• nucleophilic addition to carbonyl
• corresponds to Chapter 12. carbonyl
• corresponds to Chapter 12 and 13. Carboxylic acids
• amines, enols and enolate reactions.
• (source: Nielsen Book Data)

An important benefit for organic chemistry students is the opportunity to bridge the gap between general chemistry and organic chemistry. It is also to make sense of the myriad of in-depth concepts of organic chemistry without being overwhelmed by the necessary detail often given in a complete organic chemistry text. Here, the topics covered span the entire standard organic chemistry curriculum. The authors describe subjects which require further explanations, alternate viewpoints for understanding, and hands-on practical problems and solutions to help master the material. This text helps students apply key ideas from their general chemistry curriculum to concepts in organic chemistry.
(source: Nielsen Book Data)
The Survival Guide to Organic Chemistry: Bridging the Gap from General Chemistry enables organic chemistry students to bridge the gap between general chemistry and organic chemistry. It makes sense of the myriad of in-depth concepts of organic chemistry, without overwhelming them in the necessary detail often given in a complete organic chemistry text. Here, the topics covered span the entire standard organic chemistry curriculum. The authors describe subjects which require further explanation, offer alternate viewpoints for understanding and provide hands-on practical problems and solutions to help master the material. This text ultimately allows students to apply key ideas from their general chemistry curriculum to key concepts in organic chemistry. Key Features: Reviews key general chemistry concepts and techniques, adapted for application to important organic principles Provides practical guidance to help students make the notoriously well-known and arduous transition from general chemistry to organic chemistry Explains organic concepts and reaction mechanisms, generally expanding the focus on how to understand each step from a more intuitive viewpoint Covers concepts that need further explanation as well as those that summarize and emphasize key ideas or skills necessary in this field. An added bonus is help with organizing principles to make sense of a wide range of similar reactions and mechanisms Implements a user-friendly process to achieve the end result of problem solving Covers organic chemistry I and II concepts at the level and depth of a standard ACS organic chemistry curriculum; features practice problems and solutions to help master the material, including an extensive and comprehensive bank of practice exams with solutions.
(source: Nielsen Book Data)

• 1. Alkanes, composition, constitution, and configuration
• 2. Functional groups
• 3. Electronic structure of organic molecules
• 4. Alkenes and alkynes
• 5. Substitutions on saturated carbon atom
• 6. Nucleophilic additions
• 7. Stereochemistry, symmetry, and molecular chirality
• 8. Derivatives of carboxylic acids
• 9. Electrophilic substitutions
• 10. Pericyclic reactions
• 11. Organic natural products
• 12. Organic supramolecular and supermolecular structures.

This textbook is designed for students of biology, molecular biology, ecology, medicine, agriculture, forestry and other professions where the knowledge of organic chemistry plays an important role. The work may also be of interest to non-professionals, as well as to teachers in high schools. The book consists of 13 chapters that cover the essentials of organic chemistry, including - basic principles of structure and constitution of organic compounds, - the elements of the nomenclature, - the concepts of the nature of chemical bond, - introductions in NMR and IR spectroscopy, - the concepts and main classes of the organic reaction mechanisms, - reactions and properties of common classes or organic compounds, - and the introduction to the chemistry of the natural organic products followed by basic principles of the reactions in living cells. This second edition includes revisions and suggestions made by the readers of the first edition and the author's colleagues. In addition, it includes substantial changes compared to the first edition. The chapter on Cycloaddition has been completed by including the other pericyclic reactions (sigmatropic rearrangements, electrocyclic reactions). The chapter on Organic Natural Products has been extended to include new section covering the principles of organic synthesis. New chapter "Organic Supramolecular and Supermolecular Structures" is added. This chapter covers the basic knowledge about the molecular recognition, supramolecular structures, and the mechanisms of the enzyme catalyzed reactions. .
(source: Nielsen Book Data)

• Chapter 1. Marine Biodiscovery in a Changing World.-
• Chapter 2. The Chemistry and Chemical Ecology of Lepidopterans as Investigated in Brazil.-
• Chapter 3. A Timeline of Perezone, the First Isolated Secondary Metabolite in the New World, Covering the Period from 1852 to 2020.-
• Chapter 4. Biologically Acitive Constituents from Plants of the Genus Xanthium.-
• Chapter 5. Biologically Active Constituents from Plants of Genus Desmos.
• (source: Nielsen Book Data)

This volume describes several highly diverse subjects: Chapter 1 explores marine biodiscovery of the North-eastern Atlantic off the coast of Ireland as a model for best practice in research. The second chapter investigates Brazilian Chemical Ecology and examples of insect-plant communication studies that are mediated by natural products demonstrate the beautiful interconnectedness of species in a biome. Our third chapter comprises the advances in the science of the sesquiterpene quinone, perezone, which in 1852 was the first natural product isolated in crystalline form in the New World. The last two chapters are from a Vietnamese group and the first of these follows the phytochemistry, pharmacology, and ethnomedical uses of the genus Xanthium, which produces interesting sulfur and nitrogen containing natural products. Finally, the genus Desmos is discussed, where an overview of its constituent natural products and their in vitro pharmacological potential is described.
(source: Nielsen Book Data)

• Endohedral Metallofullerenes: an overview.- Electron Transfer in Solution.- Ions of Endohedral Fullerenes in the Gas Phase.- Electron Transfer in Solid State.- Scanning Tunneling Microscopy of Endohedral Fullerenes.- Electron Spin Resonance Studies of Metallofullerenes.- Magnetic Properties of Endohedral Metallofullerenes.- Magnetic Resonance Imaging with Endohedral Metallofullerenes.- Spin states in N@C60 and other Non-Metal Endohedral Fullerenes.- Ortho and Para Hydrogen states in H2@C60.- Quantum Computing with Endohedral Fullerenes.
• (source: Nielsen Book Data)

This book discusses recent progress in endohedral fullerenes - their production and separation techniques, as well as their characterization and properties. Furthermore, the book delves into the all-important issue of stability by investigating electron transfer between the encapsulated metal species and the carbon cage. It also reviews spin-based phenomena caused by the shielding of endohedral spin by the fullerene, and analyzes formation of the spin states by charge transfer as studied by electron spin resonance. Tuning of charge states of endohedral species and of spin states of both the cage and the cluster are explained. Finally, the book considers the recent discovery of magnetism in some endohedral fullerenes, and the potential for quantum computing.
(source: Nielsen Book Data)

• Introduction.- NHC-catalyzed Annulations of Nitroalkenes.- NHC-catalyzed Enantioselective Annulations of Enals.- NHC-catalyzed Enantioselective Annulations of , -unsaturated Carboxylic Acids.- Experimental Part.- Research Summary.
• (source: Nielsen Book Data)

• Introduction
• NHC-catalyzed Annulations of Nitroalkenes
• NHC-catalyzed Enantioselective Annulations of Enals
• NHC-catalyzed Enantioselective Annulations of α, β-unsaturated Carboxylic Acids
• Experimental Part
• Research Summary.

This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and , -unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of -substituted nitroalkenes. The scope of Rauhut-Currier reaction was successfully extended to the most challenging -substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via -addition. Highly enantiopure tetrahydropyridazinones and -amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available , -unsaturated carboxylic acids were first successfully employed to generate the , -unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.
(source: Nielsen Book Data) This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and α, β-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of β-substituted nitroalkenes. The scope of Rauhut-Currier reaction was successfully extended to the most challenging β-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via γ-addition. Highly enantiopure tetrahydropyridazinones and γ-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available α, β-unsaturated carboxylic acids were first successfully employed to generate the α, β-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.

• Part I: Development of bio-functional middle molecules.-
• 1. Introduction.-
• 2. Total Synthesis, Biological Evaluation and 3D Structural Analysis of Cyclodepsipeptide Natural Products.-
• 3. Development of the Middle-size Molecules for Alkylation to Higher-Order Structures of Nucleic Acids.-
• 4. In Situ Synthesis of Glycoconjugates on Cell Surface: Selective Cell Imaging Using Low-Affinity Glycan Ligands.-
• 5. Assembled mid-sized agents that control intracellular protein-protein interactions.-
• 6. Macrocyclic mid-sized peptides with new chemical modalities.- Part II: Achievement of highly efficient synthesis of bioactive middle molecules.-
• 7. Enantioselective Total Synthesis of Cotylenin.-
• 8. Flow Chemistry for the Construction of Polycyclic Skeleton.-
• 9. Electrochemical Synthesis of Oligosaccharides as Middle-sized Molecules.-
• 10. Efficient Synthesis of Biologically Active Peptides based on Micro-flow Amide Bond Formation.-
• 11. Design and Concise De Novo Synthesis of Artemisinin Analogs.
• (source: Nielsen Book Data)

This book highlights recently discovered aspects of "middle-size molecules, " focusing on (1) their unique bio-functions on the basis of derivatives and conjugates of natural products, saccharides, peptides, and nucleotides; (2) the synthesis of structurally complex natural products; (3) special synthetic methods for -conjugated functional molecules; and (4) novel synthetic methods using flow chemistry. Given its scope, the book is of interest to industrial researchers and graduate students in the fields of organic chemistry, medicinal chemistry, and materials science. .
(source: Nielsen Book Data)

• Chapter 1 Introduction to Chemistry and Organic Chemistry
• Chapter 2 Organic Molecules and Functional Groups
• Chapter 3 Nomenclature of Organic Molecules
• Chapter 4 Acids And Bases
• Chapter 5 Understanding Organic Reactions
• Chapter 6 Stereochemistry
• Chapter 7 Amino Acids And Proteins
• Chapter 8 Carbohydrates
• Chapter 9 Alcohols And Ethers
• Chapter 10 Spectroscopy.
• (source: Nielsen Book Data)

Basic Organic Chemistry discusses the basic concept of chemistry as well as organic chemistry. It includes detailed description of organic molecules, functional groups and the nomenclature of the organic molecules. This book also discusses the notion of acids and bases and stereochemistry of the organic molecules along with the description of amino acids, proteins, carbohydrates, alcohol and ethers. It provides the reader with the insights of basic organic chemistry so as to understand the basic organic reactions and the application of spectroscopy to study organic molecules.
(source: Nielsen Book Data)

• Synthesis of Carboxylic Acids and Esters from CO2.- Synthesis of Carbonates from Alcohols and CO2.- Recent Developments in the Synthesis of Cyclic Carbonates from Epoxides and CO2.- Synthesis of Lactones and Other Heterocycles.- Synthesis of Ureas from CO2 Homogeneous Reduction of Carbon Dioxide with Hydrogen.- Photo- and Electrochemical Valorization of Carbon Dioxide Using Earth Abundant Molecular Catalysts.
• (source: Nielsen Book Data)

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
(source: Nielsen Book Data)

• The search for anticancer agents from tropical plants.- Chemistry and biology of Mexican medicinal plants.
• (source: Nielsen Book Data)

The first review describes examples of very promising compounds discovered from plants acquired from Africa, Southeast Asia, the Americas, and the Caribbean region with potential anticancer activity. These include plant secondary metabolites of the diphyllin lignan, penta[b]benzofuran, triterpenoid, and tropane alkaloid types. The second review presents 40 more erythrinan alkaloids, which were either new or were missed out in the last major reviews, bringing to a total of 154 known erythrinan alkaloids known to date. The reported pharmacological activities of the new and known alkaloids showed a greater bias towards central nervous system and related activities. Other prominent activities reported were antifeedant or insecticidal, cytotoxicity/anti tumor/anti cancer/estrogenic, antiprotozoal, antiinflammatory, antioxidant, antifungal and antiviral activities.
(source: Nielsen Book Data)

• Chapter 1: Laboratory Safety
• Chapter 2: Laboratory Notebook
• Chapter 3: Laboratory Equipment
• Chapter 4: Basic Laboratory Operations
• Chapter 5: Determining Physical and Spectroscopic Properties
• Chapter 6: Functional-Group Analysis
• Chapter 7: Basic Operation Experiments
• Chapter 8: Organic Synthesis Experiments
• Chapter 9: Advanced Organic Synthesis Experiments
• Chapter 10: Microscale
• Chapter 11: Microscale Experiments
• Chapter 12: Green Chemistry
• Chapter 13: Green Chemistry Experiments.
• (source: Nielsen Book Data)

• 8.6. Aromatic Electrophilic Substitution of an Ester: Methyl Benzoate Nitration
• 8.7. Electrophilic Aromatic Substitution (SEAr): Preparation of a Synthetic Detergent
• 8.8. Synthesis of azo Dyes: Methyl Orange
• 8.9. Auto-Oxidation-Reduction of Aromatic Aldehydes: Cannizzaro Reaction
• 8.10. Synthesis of α, ß-unsaturated Ketones: Claisen-Schmidt Reaction
• 8.11. Saponification Reaction: Preparation of Soap from Vegetable Oil
• 8.12. Esterification: Synthesis of Aspirin
• 8.13. Difunctional Compound Chemoselectivity: Reduction of 4-nitroacetophenone
• 8.14. Perkin Reaction: Cinnamic Acid Synthesis
• 8.15. Synthesis of Imide: Preparation of N-(p-Chlorophenyl)-maleimide
• 8.16. Condensation Polymerization Reaction: Synthesis of Nylon 6,6
• 8.17. Radical Polymerization: Producing Polystyrene
• 8.18. Multistep Synthesis of a Drug: Paracetamol
• 8.19. Multistep Synthesis of an Anesthetic: Preparation of Benzocaine
• 8.20. Using Protecting Groups: Multistep Synthesis of p-nitroaniline
• 8.21. References
• Chapter 9: Advanced Organic Synthesis Experiments
• 9.1. Reductive Amination: Producing (±)-α-methylbenzylamine
• 9.2. Chiral Resolution: (±)-α-methylbenzylamine
• 9.3. Stereospecific Synthesis of Glycols: Preparationof trans-cyclohexane-1,2-diol
• 9.4. Reactivity of Carbenes: Preparation of 7,7-dichlorobicyclo [4.1.0] Heptane
• 9.5. Regioselective Halogenations: Bromation of α-methylstyrene
• 9.6. Oxidative Coupling of Alkynes: The Glaser-Eglinton-Hay Coupling
• 9.7. Diels-Alder Reactions: Butadiene and Maleic Anhydride
• 9.8. Wittig Reaction: 4-Vinylbenzoic Acid Synthesis
• 9.9. Grignard Reagents: Synthesis of Triphenylmethanol (Triphenylcarbinol).

• 11.5. Methylketone Reactivity: Acetophenone Oxidation with Sodium Hypochlorite
• 11.6. Electrophilic Aromatic Substitution (SEAr): Preparation of 4-methyl-3- and 4-methyl-2-nitroacetanilide from 4-methylaniline
• 11.7. Sandmeyer Reaction: 2-iodobenzoic Acid Synthesis
• 11.8. Synthesis of a Carbohydrate Derivative: Preparation of 2,3:5,6-di-O-isopropylidene-α-D-mannofuranose
• 11.9. Free-Radical Halogenation: 9-bromoanthracene Preparation
• 11.10. Alkylbenzene Oxidation: Reactivity of Alkyl Groups in Aromatic Compounds with KMnO4
• 11.11. Reduction of Anthraquinone: Anthrone Synthesis
• 11.12. Compounds for the Fragrance Industry: Ester Synthesis
• 11.13. Tandem Transesterification-esterification: Wintergreen Oil from Aspirin Tablets
• 11.14. Polyfunctional Molecule Reactivity: Vanillin Transformations
• 11.15. Multistep Synthesis of N-Heterocycles: Triphenylpyridine Preparation
• 11.16. Synthesis of Five-Membered Heterocycles: 2,5-dimethyl-1-phenylpyrrole by Paal-Knorr Reaction
• 11.17. References
• Chapter 12: Green Chemistry
• 12.1. Introduction
• 12.2. The 12 Principles of Green Chemistry
• 12.3. Goals of Green Chemistry
• 12.4. Parameters to Evaluate Chemical Processes
• 12.5. Green Chemistry for Undergraduate Laboratories
• 12.6. References
• Chapter 13: Green Chemistry Experiments
• 13.1. Oxidative Cleavage of Alkenes: Producing Adipic Acid with H2O2/Na2WO4
• 13.2. Halogen Addition to Alkenes: Addition of Bromine to Cyclohexene
• 13.3. Green Epoxidation: Cyclohexene Reaction with Oxone®.

• 9.10. Organometallic Compounds: Synthesis of Acetylferrocene
• 9.11. Chemoselectivity: Cinnamaldehyde Reduction with LiAlH4
• 9.12. Electrophilic Aromatic Substitution (SEAr):1,4-di-tert-butylbenzene
• 9.13. Hofmann Rearrangement: Synthesis of 2-aminobenzoic Acid (Anthranilic Acid)
• 9.14. Radical Coupling: Synthesis of Pinacol Andpinacolone
• 9.15. Synthesis of a Heterocyclic Drug: n-butyl-barbituricacid
• 9.16. Transformations of Hydroxy Ketone: Synthesis and Reactions of Benzoin
• 9.17. Enamines as Reaction Intermediates: Producing 2-acetylcyclohexanone
• 9.18. N-Heterocycle Synthesis: Producing Benzotriazol
• 9.19. Synthesis of Macrocycles: Preparation of Calix[4]pyrrole
• 9.20. Preparation of a Sports Dietary Supplement: Creatine Synthesis
• 9.21. Claisen Condensation: Synthesis of Ethyl Acetoacetate
• 9.22. Terpene Transformation: Citral Conversionin α- and ß-ionone
• 9.23. Carbohydrates: Diisopropylidene Derivative of Glucose
• 9.24. Preparation of a Nucleoside: Multistep Synthesis of Uridine Derivative
• 9.25. References
• Chapter 10: Microscale
• 10.1. Introduction
• 10.2. the Scales in the Organic Chemistry Laboratory
• 10.3. Pros of Working at the Microscale
• 10.4. Specific Microscale Lab Equipment
• 10.5. Microscale Laboratory Techniques
• 10.6. References
• Chapter 11: Microscale Experiments
• 11.1. Addition of HX to Alkenes: Synthesis of 2-bromohexane
• 11.2. Production of Margarine: Partial Hydrogenation of a Vegetable Oil with Cyclohexene and Pd(C)
• 11.3. Isomerization of Alkenes: Derivatives of Fumaric Acid from Maleic Acid
• 11.4. Nucleophilic Substitution Reaction: Ethyliodide from Ethanol.

Experimental Organic Chemistry: Laboratory Manual is designed as a primer to initiate students in Organic Chemistry laboratory work. Organic Chemistry is an eminently experimental science that is based on a well-established theoretical framework where the basic aspects are well established but at the same time are under constant development. Therefore, it is essential for future professionals to develop a strong background in the laboratory as soon as possible, forming good habits from the outset and developing the necessary skills to address the challenges of the experimental work. This book is divided into three parts. In the first, safety issues in laboratories are addressed, offering tips for keeping laboratory notebooks. In the second, the material, the main basic laboratory procedures, preparation of samples for different spectroscopic techniques, Microscale, Green Chemistry, and qualitative organic analysis are described. The third part consists of a collection of 84 experiments, divided into 5 modules and arranged according to complexity. The last two chapters are devoted to the practices at Microscale Synthesis and Green Chemistry, seeking alternatives to traditional Organic Chemistry.
(source: Nielsen Book Data)

• Frustrated Lewis Pair Catalysis: An Introduction
• Frustrated Lewis Pair Catalyzed Asymmetric Reactions
• FLP Reduction of Carbon Monoxide and Related Reactions
• FLP-Mediated C-H-Activation
• Mechanistic Insight into the Hydrogen Activation by Frustrated Lewis Pairs
• Lewis Acidic Boranes in Frustrated Lewis Pair Chemistry
• Heterogeneous Catalysis by Frustrated Lewis Pairs
• Lewis Acid−Base Pairs for Polymerization Catalysis: Recent Progress and Perspectives
• Frustrated Lewis Pairs Based on Transition Metals
• Radicals in Frustrated Lewis Pair Chemistry
• Frustrated Lewis Pair Pedagogy: Expanding Core Undergraduate Curriculum and Reinforcing Fundamental Thermodynamic Concepts
• Correction to: Frustrated Lewis Pairs Based on Transition Metals.

This volume highlights the latest research in frustrated Lewis pair (FLP) chemistry and its applications. The contributions present the recent developments of the use of FLPs in asymmetric catalysis, polymer synthesis, homogeneous and heterogeneous catalysis, as well as demonstrating their use as a pedagogical tool. The book will be of interest to researchers in academia and industry alike.
(source: Nielsen Book Data)

• 1. Nuclear Chemistry
• 2. Radioactivity
• 3. Nuclear Reaction
• 4. Interaction of Radiation with Matter
• 5. Ionization Counters
• 6. Scintillation Counter
• 7. Non-conventional Detection Techniques
• 8. Sample Preparation for Counting
• 9. Factors Affecting the Counting Efficiency
• 10. Identification of Radioactive Isotopes
• 11. Statistics of Counting
• 12. Health Hazards and Protection
• 13. Radiochemical Separation Techniques
• 14. Hot Atom-Nuclear Reaction. .

This book is designed to serve as a textbook for core courses offered to postgraduate students enrolled in chemistry. This book can also be used as a core or supplementary text for nuclear chemistry courses offered to students of chemical engineering. The book covers various topics of nuclear chemistry like Shell model, fission/fusion reaction, natural radioactive equilibrium series, nuclear reactions carried by various types of accelerators. In addition, it describes the law of decay of radioactivity, type of decay, and interaction of radiation with matter. It explains the difference between ionization counter, scintillation counter and solid state detector. This book also consists of end-of-book problems to help readers aid self-learning. The detailed coverage and pedagogical tools make this an ideal textbook for postgraduate students and researchers enrolled in various chemistry and engineering courses. This book will also be beneficial for industry professionals in the allied fields.
(source: Nielsen Book Data)

• Introduction
• Bioactive compounds from medicinal plants in myanmar
• New techniques of structure elucidation for sesquiterpenes
• Human endogenous natural products.

This book describes current understandings and recent progress in four areas: in the first one, the cytochalasans, a group of fungal derived natural products characterized by a perhydro-isoindolone core fused with a macrocyclic ring are shown to exhibit high structural diversity and a broad spectrum of bioactivities. The second one is dedicated to a description of bioactive compounds from the medicinal plants of Myanmar, the third one is dedicated to new structure elucidation techniques in the field of sesquiterpenes. The last one discusses the endogenous natural products that are produced by human cells including endogenous amines, steroids, and fatty acid derived natural products. The co-metabolism and natural product production of the human microbiome is also described including tryptophan, bile acids, choline, and cysteine.
(source: Nielsen Book Data)

• Total Synthesis of Decanolides (Nonanolides) with a Special Focus on Olefin Metathesis
• From Plant to Patient: Thapsigargin
• Antileishmanial Activity of Lignans and Neolignans
• Cryptolepine as a Lead to new Antiprotozoal Agents
• Biologically Active Constituents from Plants of the Genus Xanthium.

This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.
(source: Nielsen Book Data)

• Chapter 1. Carbohalogenation Catalyzed by Palladium and Nickel.-
• Chapter 2. Diastereoselective Pd-Catalyzed Aryl Cyanation and Aryl Borylation.-
• Chapter 3. Pd-Catalyzed Spirocyclization via C-H Activation and Benzyne/Alkyne Insertion.
• (source: Nielsen Book Data)

This book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles. Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon-carbon bonds in high atom- and step-economy. In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination. In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system. Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, and highlights its synthetic utility. Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C-H activation and -system insertion (benzynes and alkynes) to generate spirocycles. It also describes the mechanistic studies performed on these reactions.
(source: Nielsen Book Data) This book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles. Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon-carbon bonds in high atom- and step-economy. In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination. In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system. Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, and highlights its synthetic utility. Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C-H activation and π-system insertion (benzynes and alkynes) to generate spirocycles. It also describes the mechanistic studies performed on these reactions.

• Designing Impactful Green and Sustainable Chemistry Workshops for High School Teachers / Wissinger, Jane E., Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States; Knutson, Cassandra M., White Bear Lake High School, White Bear Lake, Minnesota 55110, United States; Javner, Cassidy H., Shakopee High School, Shakopee, Minnesota 55379, United States / http://dx.doi.org/10.1021/bk-2020-1344.ch001
• Educational Tools to Fight for the Planet: Education Is Our Most Powerful Weapon to Fight Climate Change / Foy, Gregory P., York College of Pennsylvania, 441 Country Club Road, York, Pennsylvania 17403, United States; Hill Foy, R. Leigh, York Suburban High School, 1800 Hollywood Drive, York, Pennsylvania 17403, United States / http://dx.doi.org/10.1021/bk-2020-1344.ch002
• The Green Fuels Depot: Sustainability, Education, and Undergraduate Research at the Community College / Jarman, Richard H., Department of Chemistry, College of DuPage, Glen Ellyn, Illinois 60137, United States / http://dx.doi.org/10.1021/bk-2020-1344.ch003
• Building Bridges between Sustainability and Chemistry in Education and Outreach / Larsen, Sarah C., Department of Chemistry, Fleming Hall, University of Houston, Houston, Texas 77204, United States; Larsen, Russell G., Department of Chemistry, Fleming Hall, University of Houston, Houston, Texas 77204, United States; Grassian, Vicki H., Departments of Chemistry & Biochemistry, Nanoengineering and Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, Mail Code 0314, La Jolla, California 92093, United States / http://dx.doi.org/10.1021/bk-2020-1344.ch004
• Greening the Senior High School Chemistry Curriculum: An Action Research Initiative / Linkwitz, Michael, Otto-Hahn-Gymnasium, Bergisch-Gladbach 51429, Germany; Eilks, Ingo, Department of Biology and Chemistry, University of Bremen, Bremen 28334, Germany / http://dx.doi.org/10.1021/bk-2020-1344.ch005
• Education for Sustainable Development in High School through Inquiry-Type Socio-Scientific Issues / Mamlok-Naaman, Rachel, Department of Science Teaching, Weizmann Institute of Science, Israel; Mandler, Daphna, Department of Science Teaching, Weizmann Institute of Science, Israel / http://dx.doi.org/10.1021/bk-2020-1344.ch006
• Incorporating Sustainability into Chemistry Education by Teaching through Project-Based Learning / Hugerat, Muhamad, The Academic Arab College for Education in Israel-Haifa, 22 Hahashmal Street, Haifa 33145, P.O. Box 8349, Israel / http://dx.doi.org/10.1021/bk-2020-1344.ch007
• Sustainability and Green Chemistry Education: Innovative and Contextualized Experiences from the Undergraduate Chemistry Courses at the Federal University of São Carlos, Brazil / Zuin, Vânia Gomes, Department of Chemistry, Postgraduate Programs in Education and Chemistry, Federal University of São Carlos (UFSCar), Rodovia Washington Luís (SP-310), km 235, 13565-905 São Carlos, Brazil, The University of York, Green Chemistry Centre of Excellence, Heslington, York YO10 5DD, United Kingdom; Gomes, Caroindes Julia Corrêa, Postgraduate Program in Education, Federal University of São Carlos (UFSCar) / http://dx.doi.org/10.1021/bk-2020-1344.ch008
• Evolution of an ACS-CEI Award-Winning Undergraduate Course in Catalytic Organic Chemistry / Rousseaux, Sophie A. L., Department of Chemistry, University of Toronto, Toronto M5S 3H6, Canada; Dicks, Andrew P., Department of Chemistry, University of Toronto, Toronto M5S 3H6, Canada / http://dx.doi.org/10.1021/bk-2020-1344.ch009
• A Holistic Approach to Incorporating Sustainability into Chemistry Education in Israel / Shwartz, Yael, The Departments of Science Teaching, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, Israel; Eidin, Emil, CREATE for STEM Institute, Michigan State University, 620 Farm Lane, East Lansing, Michigan 48825, United States; Marchak, Debora, The Departments of Science Teaching, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, Israel; Kesner, Miri, The Departments of Science Teaching, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, Israel; Green, Neta Avraham, The Departments of Science Teaching, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, Israel; Marom, Eldad, Open University, 1 University Road, P.O. Box 808, Ra'ana 43107, Israel; Cahen, David, The Departments of Science Teaching, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, Israel; Hofstein, Avi, The Departments of Science Teaching, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, Israel, The Arabic Academic College, 22 HeHashmal Street, Haifa 33145, Israel; Dori, Yehudit Judy, Faculty for Education in Science and Technology, Technion, Israel Institute of Technology, Haifa 3200003, Israel, School of Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States / http://dx.doi.org/10.1021/bk-2020-1344.ch010
• Malaysian Experiences of Incorporating Green Chemistry into Teaching and Learning of Chemistry across Secondary and Tertiary Education / Karpudewan, Mageswary, School of Educational Studies, Universiti Sains Malaysia, 11800 USM Penang, Malaysia / http://dx.doi.org/10.1021/bk-2020-1344.ch011
• Editors' Biographies / http://dx.doi.org/10.1021/bk-2020-1344.ot001

A key step toward embracing sustainability and green chemistry is educating the next generation of chemists about their importance. To this aim, the ACS-CEI Award for Incorporation of Sustainability into Chemistry Education recognizes exemplary contributions. This two-volume set contains chapters written by recent award winners. This volume explores current efforts across the world to incorporate environmentally conscious material into chemistry curricula. Educators spanning K-12, undergraduate, and graduate classrooms provide perspectives on new developments as well as methods to introduce preservice and current teachers to environmental teaching best practices.
(source: Nielsen Book Data)

• Frontmatter
• Preface
• Contents
• 1. Flash Point
• 2. Autoignition
• 3. Flammability Limit
• 4. Heat of Combustion
• 5. Polymer Flammability
• Problems
• Answers to Problems
• List of Symbols
• Appendix
• References
• Index

The combustion properties of organic materials are used to assess their safety specifications. This knowledge is necessary to avoid potentially disastrous fires. The experimental determination of the combustion properties of a new organic compound is laborious and sometimes even impossible. This book describes methods for the determination and prediction of the combustion properties of organic compounds, along with some examples and exercises.
(source: Nielsen Book Data)

• Part I. Nucleation and crystal growth
• X-Ray Birefringence Imaging (XBI): A New Technique for Spatially Resolved Mapping of Molecular Orientations in Materials / Kenneth D. M. Harris, Rhian Patterson, Yating Zhou, Stephen P. Collins
• Direct Visualization of Crystal Formation and Growth Probed by the Organic Fluorescent Molecules / Fuyuki Ito
• Anti-solvent Crystallization Method for Production of Desired Crystalline Particles / Hiroshi Takiyama
• Crystal Nucleation of Proteins Induced by Surface Plasmon Resonance / Tetsuo Okutsu
• Control of Crystal Size Distribution and Polymorphs in the Crystallization of Organic Compounds / Koichi Igarashi, Hiroshi Ooshima
• Managing Thermal History to Stabilize/Destabilize Pharmaceutical Glasses / Kohsaku Kawakami
• Part II. Structure and Design of Crystals
• Supramolecular, Hierarchical, and Energetical Interpretation of Organic Crystals: Generation of Supramolecular Chirality in Assemblies of Achiral Molecules / Mikiji Miyata, Seiji Tsuzuki
• Relationship Between Atomic Contact and Intermolecular Interactions: Significant Importance of Dispersion Interactions Between Molecules Without Short Atom–Atom Contact in Crystals / Seiji Tsuzuki
• Pharmaceutical Multicomponent Crystals: Structure, Design, and Properties / Okky Dwichandra Putra, Hidehiro Uekusa
• The Design of Porous Organic Salts with Hierarchical Process / Norimitsu Tohnai
• Layered Hydrogen-Bonded Organic Frameworks as Highly Crystalline Porous Materials / Ichiro Hisaki, Qin Ji, Kiyonori Takahashi, Takayoshi Nakamura
• Kinetic Assembly of Porous Coordination Networks Leads to Trapping Unstable Elemental Allotropes / Hiroyoshi Ohtsu, Pavel M. Usov, Masaki Kawano
• Creation of Organic-Metal Hybridized Nanocrystals Toward Nonlinear Optics Applications / Tsunenobu Onodera, Rodrigo Sato, Yoshihiko Takeda, Hidetoshi Oikawa
• Part III. Function
• Luminescent Crystal–Control of Excited-State Intramolecular Proton Transfer (ESIPT) Luminescence Through Polymorphism / Toshiki Mutai
• Solid-State Fluorescence Switching Using Photochromic Diarylethenes / Seiya Kobatake, Tatsumoto Nakahama
• Circularly Polarized Luminescence from Solid-State Chiral Luminophores / Yoshitane Imai
• Azulene-Based Materials for Organic Field-Effect Transistors / Hiroshi Katagiri
• Electrochemical Functions of Nanostructured Liquid Crystals with Electronic and Ionic Conductivity / Masahiro Funahashi
• Part IV. Kryptoracemates / Edward R. T. Tiekink
• Twenty-Five Years’ History, Mechanism, and Generality of Preferential Enrichment as a Complexity Phenomenon / Rui Tamura, Hiroki Takahashi, Gérard Coquerel
• Asymmetric Synthesis Involving Dynamic Enantioselective Crystallization / Masami Sakamoto
• Molecular Recognition by Inclusion Crystals of Chiral Host Molecules Having Trityl and Related Bulky Groups / Motohiro Akazome, Shoji Matsumoto
• Asymmetric Catalysis and Chromatographic Enantiomer Separation by Homochiral Metal–Organic Framework: Recent Advances
• Koichi Tanaka
• Part V. Solid-State Polymerization of Conjugated Acetylene Compounds to Form pi-conjugated polymers / Shuji Okada, Yoko Tatewaki, Ryohei Yamakado
• Click Chemistry to Metal-Organic Frameworks as a Synthetic Tool for MOF and Applications for Functional Materials / Kazuki Sada, Kenta Kokado.

This book summarizes and records the recent notable advances in diverse topics in organic crystal chemistry, which has made substantial progress along with the rapid development of a variety of analysis and measurement techniques for solid organic materials. This review book is one of the volumes that are published periodically on this theme. The previous volume, published in 2015, systematically summarized the remarkable progress in assorted topics of organic crystal chemistry using organic solids and organic-inorganic hybrid materials during the previous 5 years, and it has been widely read. The present volume also shows the progress of organic solid chemistry in the last 5 years, with contributions mainly by invited members of the Division of Organic Crystal Chemistry of the Chemical Society of Japan (CSJ), together with prominent invited authors from countries other than Japan.
(source: Nielsen Book Data)

• Sesterterpenoids.- Secondary Metabolites from Marine-Derived Fungi from China.
• (source: Nielsen Book Data)

The first chapter in volume 111 summarizes research on the sesterterpenoids, which are known as a relatively small group of natural products. However, they express a variety of simple to complicated chemical structures. This chapter focuses on the chemical structures of sesterterpenoids and how their structures are synthesized in Nature. The second chapter is devoted to marine-derived fungi, which play an important role in the search for structurally unique secondary metabolites, some of which show promising pharmacological activities that make them useful leads for drug discovery. Marine natural product research in China in general has made enormous progress in the last two decades as described in this chapter on fungal metabolites. This contribution covers 613 new natural products reported from 2001 to 2017 from marine-derived fungi obtained from algae, sponges, corals, and other marine organisms from Chinese waters.
(source: Nielsen Book Data)

• Prologue Chapter 1 Structure and Bonding Chapter 2 Acids and Bases Chapter 3 Introduction to Organic Molecules and Functional Groups Chapter 4 Alkanes Chapter 5 Stereochemistry Chapter 6 Understanding Organic Reactions Chapter 7 Alkyl Halides and Nucleophilic Substitution Chapter 8 Alkyl Halides and Elimination Reactions Chapter 9 Alcohols, Ethers, and Related Compounds Chapter 10 Alkenes Chapter 11 Alkynes Chapter 12 Oxidation and Reduction Chapter 13 Mass Spectrometry and Infrared Spectroscopy Chapter 14 Nuclear Magnetic Resonance Spectroscopy Chapter 15 Radical Reactions Chapter 16 Conjugation, Resonance, and Dienes Chapter 17 Benzene and Aromatic Compounds Chapter 18 Reactions of Aromatic Compounds Chapter 19 Carboxylic Acids and the Acidity of the O-H Bond Chapter 20 Introduction to Carbonyl Chemistry: Organometallic Reagents
• Oxidation and Reduction Chapter 21 Aldehydes and Ketones-Nucleophilic Addition Chapter 22 Carboxylic Acids and Their Derivatives-Nucleophilic Acyl Substitution Chapter 23 Substitution Reactions of Carbonyl Compounds at the Carbon Chapter 24 Carbonyl Condensation Reactions Chapter 25 Amines Chapter 26 Amino Acids and Proteins Chapter 27 Carbohydrates Chapter 28 Lipids Chapter 29 Carbon-Carbon Bond-Forming Reactions in Organic Synthesis Chapter 30 Pericyclic Reactions Chapter 31 Synthetic Polymers (Available online).
• (source: Nielsen Book Data)

Smith's Organic Chemistry with Biological Topics continues to breathe new life into the organic chemistry world. This new fifth edition retains its popular delivery of organic chemistry content in a student-friendly format. Janice Smith draws on her extensive teaching background to deliver organic chemistry in a way in which students learn: with limited use of text paragraphs, and through concisely written bulleted lists and highly detailed, well-labeled "teaching" illustrations. The fifth edition features a modernized look with updated chemical structures throughout. Because of the close relationship between chemistry and many biological phenomena, Organic Chemistry with Biological Topics presents an approach to traditional organic chemistry that incorporates the discussion of biological applications that are understood using the fundamentals of organic chemistry. See the New to Organic Chemistry with Biological Topics section for detailed content changes. Don't make your text decision without seeing Organic Chemistry, 5th edition by Janice Gorzynski Smith and Heidi Vollmer-Snarr! .
(source: Nielsen Book Data)

• Using Flipped Classroom Settings to Shift the Focus of a General Chemistry Course from Topic Knowledge to Learning and Problem-Solving Skills: A Tale of Students Enjoying the Class They Were Expecting to Hate / Ramella, Daniele, College of Science and Technology-Department of Chemistry, Temple University, 1901 North 13th Street, Philadelphia, Pennsylvania 19122, United States; Brock, Benjamin E., CAT-Center for Advancement of Teaching, Temple University, Philadelphia, Pennsylvania 19122, United States, School of Education, Temple University, Philadelphia, Pennsylvania 19122, United States; Velopolcek, Maria K., Department of Chemistry, Duke University, Durham, North Carolina 27701, United States; Winters, Kyle P., School of Dentistry, Temple University, Philadelphia, Pennsylvania 19140, United States / http://dx.doi.org/10.1021/bk-2019-1322.ch001
• Combining Pre-class Preparation with Collaborative In-Class Activities to Improve Student Engagement and Success in General Chemistry / Blaser, Mark / http://dx.doi.org/10.1021/bk-2019-1322.ch002
• Using Clicker-Based Group Work Facilitated by a Modified Peer Instruction Process in a Highly Successful Flipped General Chemistry Classroom / Pollozi, Shejla, Department of Chemistry, Lehman College of the City University of New York, 250 Bedford Park Boulevard West, Bronx, New York 10468, United States, Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States; Haddad, Ibrahim, Department of Chemistry, Lehman College of the City University of New York, 250 Bedford Park Boulevard West, Bronx, New York 10468, United States; Tyagi, Aanchal, Department of Chemistry, Lehman College of the City University of New York, 250 Bedford Park Boulevard West, Bronx, New York 10468, United States; Mills, Pamela, Department of Chemistry, Lehman College of the City University of New York, 250 Bedford Park Boulevard West, Bronx, New York 10468, United States, Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States; McGregor, Donna, Department of Chemistry, Lehman College of the City University of New York, 250 Bedford Park Boulevard West, Bronx, New York 10468, United States, Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States / http://dx.doi.org/10.1021/bk-2019-1322.ch003
• Maximizing Learning Efficiency in General Chemistry / Cracolice, Mark S., Department of Chemistry & Biochemistry, University of Montana, Missoula, Montana 59812, United States; Queen, Matt, Department of Biological and Physical Sciences, Montana State University Billings, 1500 University Drive, Billings, Montana 59101, United States / http://dx.doi.org/10.1021/bk-2019-1322.ch004
• Flipping General Chemistry in Small Classes: Students' Perception and Success / Hutchinson-Anderson, Kelly M. / http://dx.doi.org/10.1021/bk-2019-1322.ch005
• Active Learning in the Large Lecture Hall Format / LaBrake, Cynthia / http://dx.doi.org/10.1021/bk-2019-1322.ch006
• Large-Scale, Team-Based Curriculum Transformation and Student Engagement in General Chemistry I and II / Lamont, Liana B., Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States; Stoll, Lindy K., Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States; Pesavento, Theresa M., Department of Academic Technology, University of Wisconsin-Madison, 1305 Linden Drive, Madison, Wisconsin 53706, United States; Bain, Rachel L., Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States; Landis, Clark R., Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States; Sibert, Edwin L., Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States / http://dx.doi.org/10.1021/bk-2019-1322.ch007
• Active Learning in Hybrid-Online General Chemistry / Miller, Dionne A. / http://dx.doi.org/10.1021/bk-2019-1322.ch008
• A Course Transformation to Support First-Year Chemistry Education for Engineering Students / Addison, Christopher J.; Núñez, José Rodríguez / http://dx.doi.org/10.1021/bk-2019-1322.ch009
• Flipped Classroom Learning Environments in General Chemistry: What Is the Impact on Student Performance in Organic Chemistry? / Eichler, Jack F., Department of Chemistry, University of California, Riverside, Riverside, California 92521, United States; Peeples, Junelyn, Department of Chemistry, University of California, Riverside, Riverside, California 92521, United States / http://dx.doi.org/10.1021/bk-2019-1322.ch010
• Editors' Biographies / http://dx.doi.org/10.1021/bk-2019-1322.ot001

• Introduction to Active Learning in Organic Chemistry and Essential Terms / Houseknecht, Justin B., Department of Chemistry, Wittenberg University, P.O. Box 720, Springfield, Ohio 45501, United States; Leontyev, Alexey, Department of Chemistry and Biochemistry, North Dakota State University, Dept 2735, P.O. Box 6050, Fargo, North Dakota 58108, United States; Maloney, Vincent M., Department of Chemistry, Purdue University Fort Wayne, 2101 East Coliseum Boulevard, Fort Wayne, Indiana 46805-1499, United States; Welder, Catherine O., Department of Chemistry, Dartmouth College, 41 College Street, 6128 Burke Laboratory, Hanover, New Hampshire 03755, United States / http://dx.doi.org/10.1021/bk-2019-1336.ch001
• Using Just-in-Time Teaching To Engage Rural Students in Small Enrollment Organic Chemistry Classes / Lenczewski, Mary S. / http://dx.doi.org/10.1021/bk-2019-1336.ch002
• Finding Time for Active Learning with Just-in-Time Teaching / Umile, Thomas P. / http://dx.doi.org/10.1021/bk-2019-1336.ch003
• Clickers in Small Undergraduate Organic Chemistry Courses: Increasing Student Engagement while Improving Perception / DeCicco, Racquel C. / http://dx.doi.org/10.1021/bk-2019-1336.ch004
• Collaborative Problem Solving: Using Clickers and Cloud Folders To Enhance Student Learning in Organic Chemistry / Jeske, Ryan C., Department of Chemistry, Ball State University, Cooper Physical Science Building, Room 305, Muncie, Indiana 47306, United States; Jones, James A., Research and Academic Effectiveness, Ball State University, 2000 University Avenue, Muncie, Indiana 47306, United States; Stanford, Courtney L., Department of Chemistry, Ball State University, Cooper Physical Science Building, Room 305, Muncie, Indiana 47306, United States / http://dx.doi.org/10.1021/bk-2019-1336.ch005
• Student Use of Classroom Response Systems To Promote Active Learning / Shea, Kevin M. / http://dx.doi.org/10.1021/bk-2019-1336.ch006
• The Mechanisms App and Platform:: A New Game-Based Product for Learning Curved Arrow Notation / Winter, Julia E., Alchemie Solutions, Inc., 950 Stephenson Highway, Troy, Michigan 48083, United States; Wegwerth, Sarah E., Alchemie Solutions, Inc., 950 Stephenson Highway, Troy, Michigan 48083, United States; DeKorver, Brittland K., Department of Chemistry, Grand Valley State University, 1 Campus Drive, Allendale, Michigan 49401, United States; Morsch, Layne A., Department of Chemistry, University of Illinois Springfield, One University Plaza, MS HSB 314, Springfield, Illinois 62703, United States; DeSutter, Dane, Learning Sciences Research Institute, 1240 West Harrison Street, Chicago, Illinois 60607, United States; Goldman, Lawrence M., Department of Chemistry, University of Washington 4000 15th Avenue NE, Seattle, Washington 98195, United States; Reutenauer, Lauren M., Department of Chemistry, Amherst College, 220 South Pleasant Street, Amherst, Massachusetts 01002, United States / http://dx.doi.org/10.1021/bk-2019-1336.ch007
• An All-In Approach to Flipping the Organic Chemistry Classroom Using Elements of Peer-Led Team Learning with Undergraduate Learning Assistants / Welder, Catherine O. / http://dx.doi.org/10.1021/bk-2019-1336.ch008
• Flipping an Allied Health Survey Course of Organic and Biological Chemistry / Schirch, Douglas / http://dx.doi.org/10.1021/bk-2019-1336.ch009
• Benefits of a Partially Flipped Organic Chemistry Course to Student Perceptions and Learning / Shattuck, James C. / http://dx.doi.org/10.1021/bk-2019-1336.ch010
• Effective Implementations of a Partially Flipped Classroom for Large-Enrollment Organic Chemistry Courses / Casselman, Matthew D. / http://dx.doi.org/10.1021/bk-2019-1336.ch011
• Cooperative Learning in Large Sections of Organic Chemistry: Transitioning to POGIL / Canelas, Dorian A., Department of Chemistry, Duke University, Durham, North Carolina 27708, United States; Hill, Jennifer L., Trinity College Office of Assessment, Duke University, Durham, North Carolina 27708, United States; Carden, Robert G., Department of Chemistry, Villanova University, Villanova, Pennsylvania 19085, United States / http://dx.doi.org/10.1021/bk-2019-1336.ch012
• Combining POGIL and a Flipped Classroom Methodology in Organic Chemistry / DeMatteo, Matthew P. / http://dx.doi.org/10.1021/bk-2019-1336.ch013
• Editors' Biographies / http://dx.doi.org/10.1021/bk-2019-1336.ot001

Organic chemistry courses are often difficult for students, and instructors are constantly seeking new ways to improve student learning. This volume details active learning strategies implemented at a variety of institutional settings, including small and large; private and public; liberal arts and technical; and highly selective and open-enrollment institutions. Readers will find detailed descriptions of methods and materials, in addition to data supporting analyses of the effectiveness of reported pedagogies.
(source: Nielsen Book Data)

• Communicating Chemistry: An Introduction / Crawford, Garland L., Department of Chemistry, Mercer University, Macon, Georgia 31207, United States; Kloepper, Kathryn D., Department of Chemistry, Mercer University, Macon, Georgia 31207, United States; Meyers, John J., Department of Chemistry and Physics, Clayton State University, Morrow, Georgia 30260, United States; Singiser, Richard H., Department of Chemistry and Physics, Clayton State University, Morrow, Georgia 30260, United States / http://dx.doi.org/10.1021/bk-2019-1327.ch001
• From Cornerstone to Capstone: Perspectives on Improving Student Communication Skills through Intentional Curricular Alignment / Trogden, Bridget G., Department of Engineering and Science Education and Division of Undergraduate Studies, Vickery Hall, Clemson University, Clemson, South Carolina 29631, United States; Mazer, Joseph P., Department of Communication, Daniel Hall, Clemson University, Clemson, South Carolina 29631, United States / http://dx.doi.org/10.1021/bk-2019-1327.ch002
• Linking Oral Communication in the Chemistry Classroom to the American Association of Colleges and Universities VALUE Rubric / Potts, Gretchen E. / http://dx.doi.org/10.1021/bk-2019-1327.ch003
• Developing Undergraduate Students' Critical Thinking Skills in a Chemical Communications Course and Beyond / O'Donnell, Jodi L., Department of Chemistry and Biochemistry, Siena College, Loudonville, New York 12211, United States; Karr, Jesse W., Department of Chemistry and Biochemistry, Siena College, Loudonville, New York 12211, United States; Lipinski, Bryce M., Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States; Frederickson, Danielle, Department of Chemistry and Biochemistry, Siena College, Loudonville, New York 12211, United States / http://dx.doi.org/10.1021/bk-2019-1327.ch004
• Practicing Multimodal Chemistry Communication through Online Collaborative Learning / Wentzel, Michael T., Department of Chemistry, Augsburg University, 2211 Riverside Avenue, Minneapolis, Minnesota 55454, United States; Ripley, Isaiah, Department of Chemistry, Augsburg University, 2211 Riverside Avenue, Minneapolis, Minnesota 55454, United States; McCollum, Brett M., Department of Chemistry and Physics, Mount Royal University, Calgary, Alberta, Canada T3E 6K6; Morsch, Layne A., Department of Chemistry, University of Illinois Springfield, One University Plaza, MS HSB 314, Springfield, Illinois 62703, United States / http://dx.doi.org/10.1021/bk-2019-1327.ch005
• Examining the Use of Scientific Argumentation Strategies in Deaf and Hard-of-Hearing Learning Contexts To Teach Climate Science / Ross, Annemarie D., Department of Science and Mathematics, National Technical Institute for the Deaf at the Rochester Institute of Technology, Rochester, New York 14623, United States; Yerrick, Randy, Department of Learning and Instruction, The State University of New York at Buffalo, Buffalo, New York 14260, United States; Pagano, Todd, Department of Science and Mathematics, National Technical Institute for the Deaf at the Rochester Institute of Technology, Rochester, New York 14623, United States / http://dx.doi.org/10.1021/bk-2019-1327.ch006
• Implementing Reciprocal Peer Teaching in the Instrumental Analysis Laboratory / Dickson-Karn, Nicole M. / http://dx.doi.org/10.1021/bk-2019-1327.ch007
• Oral Alternatives to Traditional Written Lab Reports / Berns, Veronica M. / http://dx.doi.org/10.1021/bk-2019-1327.ch008
• Advancing Scientific Communication with Infographics: An Assignment for Upper-Level Chemistry Classes / Jones, Rebecca M. / http://dx.doi.org/10.1021/bk-2019-1327.ch009
• Engaging Nonchemistry Majors Through Application-Based Final Projects in the Elementary Organic Chemistry Classroom / Yearty, Kasey L.; Morrison, Richard W. / http://dx.doi.org/10.1021/bk-2019-1327.ch010
• Structured Presentations That Tie Chemistry Course Content to Everyday Context / Miller, Aimee L. / http://dx.doi.org/10.1021/bk-2019-1327.ch011
• Can You Teach Subatomic Particles with WKRP in Cincinnati and Climate Change with Last Week Tonight with John Oliver: Conveying Chemistry to Nonscience Majors Using Videos / Hickey, Sean P. / http://dx.doi.org/10.1021/bk-2019-1327.ch012
• Building Scientific Communication Skills through MythBusters Videos and Community Engagement / Flener-Lovitt, Charity, School of Science, Technology, Engineering, and Mathematics, University of Washington Bothell, Bothell, Washington 98011, United States; Shinneman, Avery Cook, School of Interdisciplinary Arts and Sciences, University of Washington Bothell, Bothell, Washington 98011, United States; Adams, Kara, Office of Community-Based Learning and Research, University of Washington Bothell, Bothell, Washington 98011, United States / http://dx.doi.org/10.1021/bk-2019-1327.ch013
• Why Communicating Chemistry Can Be Complicated / Whitcombe, Todd / http://dx.doi.org/10.1021/bk-2019-1327.ch014
• Investigating the Content Connections of General Chemistry and Chemistry in the News / Lolinco, Annabelle, Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States; Kindle, Christina, Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States; Holme, Thomas, Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States / http://dx.doi.org/10.1021/bk-2019-1327.ch015
• Using Art To Communicate Chemistry / Williams, Vance E. / http://dx.doi.org/10.1021/bk-2019-1327.ch016
• The Future of Chemistry Communication Is Digital: Overcoming Hesitancies for Online Engagement / Mojarad, Sarah / http://dx.doi.org/10.1021/bk-2019-1327.ch017
• Encouraging Bridges: Connecting Science Students to Public Problem-Solving through Science Communication / Drury, Sara A. Mehltretter, Department of Rhetoric, Wabash College, Crawfordsville, Indiana 47933, United States; Rush, Ryan A., Department of Psychology, Franklin College, Franklin, Indiana 46131, United States; Wilder, Sarah E., Department of Communication Studies, Luther College, Decorah, Iowa 52101, United States; Wysocki, Laura M., Department of Chemistry, Wabash College, Crawfordsville, Indiana 47933, United States / http://dx.doi.org/10.1021/bk-2019-1327.ch018
• Editors' Biographies / http://dx.doi.org/10.1021/bk-2019-1327.ot001

• Enhancing Student Retention in General and Organic Chemistry: An Introduction / Gupta, Tanya, Department of Chemistry & Biochemistry, South Dakota State University, Brookings, South Dakota 57007, United States; Hartwell, Supaporn Kradtap, Department of Chemistry, Xavier University, Cincinnati, Ohio 45207, United States / http://dx.doi.org/10.1021/bk-2019-1341.ch001
• Gateways to Completion: Reconceptualizing General Chemistry I to Enhance Student Success at Eastern Michigan University / Johnson, Amy Flanagan; Nord, Ross / http://dx.doi.org/10.1021/bk-2019-1341.ch002
• Low DWF Rate General Chemistry Course: It Is Possible / Hayes, Ryan T.; Randall, David W. / http://dx.doi.org/10.1021/bk-2019-1341.ch003
• Improving Student Success One Step at a Time / Casey, Kirsten A.; Tracey, Lynn J.; Miller, Kristine E.; Gabbard, Elizabeth A. / http://dx.doi.org/10.1021/bk-2019-1341.ch004
• Creating a System of Integrated Support for General Chemistry Cohorts Utilizing Student-Driven Laboratory Curriculum / Chamberlin, Stacy I.; Mier, Lynetta M. / http://dx.doi.org/10.1021/bk-2019-1341.ch005
• Reconfiguring the General Chemistry I Laboratory Course at a Small PUI / Bolyard, Lori A.; Neal, Brad M.; Cutler, Ann R.; Styers-Barnett, David K. / http://dx.doi.org/10.1021/bk-2019-1341.ch006
• Using Graduate and Experienced Undergraduate Students to Support Introductory Courses / Kerr, Emily F., Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States; Samuels, Martin, Derek Bok Center for Teaching and Learning, Harvard University, Cambridge, Massachusetts 02138, United States / http://dx.doi.org/10.1021/bk-2019-1341.ch007
• Molecular Sciences Made Personal: Developing Curiosity in General and Organic Chemistry with a Multi-Semester Utility Value Intervention / Zavala, Jose A., Department of Chemistry, University of Illinois Urbana-Champaign, 505 S. Mathews Ave., Urbana, Illinois 61801, United States; Chadha, Rajat, Center for Innovation in Teaching and Learning, University of Illinois Urbana-Champaign, 505 E. Armory Ave., Champaign, Illinois 61820, United States; Steele, Diana M., Center for Innovation in Teaching and Learning, University of Illinois Urbana-Champaign, 505 E. Armory Ave., Champaign, Illinois 61820, United States; Ray, Christian, Department of Chemistry, University of Illinois Urbana-Champaign, 505 S. Mathews Ave., Urbana, Illinois 61801, United States; Moore, Jeffrey S., Department of Chemistry, University of Illinois Urbana-Champaign, 505 S. Mathews Ave., Urbana, Illinois 61801, United States, Department of Material Science and Engineering, University of Illinois Urbana-Champaign, 1304 W. Green St., Urbana, Illinois 61801, United States, Beckman Institute for the Advancement of Science and Technology, University of Illinois Urbana-Champaign, 405 N. Mathews Ave., Urbana, Illinois 61801, United States / http://dx.doi.org/10.1021/bk-2019-1341.ch008
• Enhancing Student Learning and Retention in Organic Chemistry: Benefits of an Online Organic Chemistry Preparatory Course / King, Susan M., University of California, Irvine, 2133 Natural Sciences II, Irvine, California 92697-2025, United States; Zhou, Ninger, University of California, Irvine, 3200 Education, Irvine, California 92697-5500, United States; Fischer, Christian, University of California, Irvine, 3200 Education, Irvine, California 92697-5500, United States; Rodriguez, Fernando, University of California, Irvine, 3200 Education, Irvine, California 92697-5500, United States; Warschauer, Mark, University of California, Irvine, 3200 Education, Irvine, California 92697-5500, United States / http://dx.doi.org/10.1021/bk-2019-1341.ch009
• Increasing Student Mastery of Organic Chemistry through Planned Interface of NMR Lecture and Laboratory Activities / Schelble, Susan M.; Magee, Chad L.; Dohoney, Ryan A. / http://dx.doi.org/10.1021/bk-2019-1341.ch010
• Evaluation of a Peer-Led Team Learning-Flipped Classroom Reform in Large Enrollment Organic Chemistry Courses / Mutanyatta-Comar, Joan; Mooring, Suazette R. / http://dx.doi.org/10.1021/bk-2019-1341.ch011
• Factors Influencing Student Engagement, Motivation, and Learning: Strategies to Enhance Student Success and Retention / Gute, Brian D.; Wainman, Jacob W. / http://dx.doi.org/10.1021/bk-2019-1341.ch012
• Acknowledgments / http://dx.doi.org/10.1021/bk-2019-1341.ot002
• Editors' Biographies / http://dx.doi.org/10.1021/bk-2019-1341.ot001

General and organic chemistry are part of many STEM majors and subsequent STEM careers. Student success in these (gatekeeping) courses can dramatically alter a student's path. This volume discusses courses and curricula designed to improve retention and lower the number of students receiving a D, F, or W in a course. Faculty, administrators, educational policy developers, and other readers will find effective interventions that can be applied at diverse institutions to increase student success in chemistry.
(source: Nielsen Book Data)

• Game of Thrones, Breaking Bad, Nicolas Cage, Harry Potter, Pulp Fiction, and More: The Key Ingredients in Teaching Biochemistry to Nonscience Majors / Hickey, Sean P. / http://dx.doi.org/10.1021/bk-2019-1325.ch001
• CHEMTERTAINMENT: Using Video Clips from Movies, Television Series, and YouTube To Enhance the Teaching and Learning Experience of an Introductory Chemistry Lecture Class / Mojica, Elmer-Rico E. / http://dx.doi.org/10.1021/bk-2019-1325.ch002
• Teaching with Videos and Animations: Tuning in, Getting Turned on, and Building Relationships / Starkey, Laurie S. / http://dx.doi.org/10.1021/bk-2019-1325.ch003
• What To Do with Class Time? / Parr, Jessica / http://dx.doi.org/10.1021/bk-2019-1325.ch004
• Use of Multimedia Tools in the Chemistry Classroom To Foster Student Participation / Broyer, Rebecca M. / http://dx.doi.org/10.1021/bk-2019-1325.ch005
• Video Assessment of Students' Lab Skills / Skibo, Catherine / http://dx.doi.org/10.1021/bk-2019-1325.ch006
• Videotaping Experiments in an Analytical Chemistry Laboratory Course at Pace University / Mojica, Elmer-Rico E.; Upmacis, Rita K. / http://dx.doi.org/10.1021/bk-2019-1325.ch007
• Impact of Student-Created Mechanism Videos in Organic Chemistry 2 Labs / Gupta, Nirzari; Nikles, Jacqueline / http://dx.doi.org/10.1021/bk-2019-1325.ch008
• Final Thoughts on Videos in Chemistry Education / Parr, Jessica / http://dx.doi.org/10.1021/bk-2019-1325.ch009
• Editor Biography / http://dx.doi.org/10.1021/bk-2019-1325.ot001

The application of new methods for engaging students with content is complicated by the lack of real-life models. This work provides the reader with rich examples of ways that faculty have implemented videos to help students prepare for classwork. Describing the practical use of tools, such as SMART boards and iPad apps, chapters serve as how-to manuals to support faculty looking to put these tools into practice in their chemistry courses, from high school and general chemistry to analytical chemistry and special topics.
(source: Nielsen Book Data)

• Introduction to spectroscopy (Spectrometry)
• Ultraviolet (UV) and visible spectroscopy.
• Infrared (IR) spectroscopy.
• Raman spectroscopy.
• Proton nuclear magnetic resonance (PMR or ¹H NMR) spectroscopy.
• ¹³C NMR spectroscopy.
• Electron spin resonance (ESR) spectroscopy.
• Mass spectroscopy (MS)
• Spectroscopic solutions of structural problems.

Organic Spectroscopy presents the derivation of structural information from UV, IR, Raman, 1H NMR, 13C NMR, Mass and ESR spectral data in such a way that stimulates interest of students and researchers alike. The application of spectroscopy for structure determination and analysis has seen phenomenal growth and is now an integral part of Organic Chemistry courses. This book provides: -A logical, comprehensive, lucid and accurate presentation, thus making it easy to understand even through self-study; -Theoretical aspects of spectral techniques necessary for the interpretation of spectra; -Salient features of instrumentation involved in spectroscopic methods; -Useful spectral data in the form of tables, charts and figures; -Examples of spectra to familiarize the reader; -Many varied problems to help build competence ad confidence; -A separate chapter on `spectroscopic solutions of structural problems' to emphasize the utility of spectroscopy. Organic Spectroscopy is an invaluable reference for the interpretation of various spectra. It can be used as a basic text for undergraduate and postgraduate students of spectroscopy as well as a practical resource by research chemists. The book will be of interest to chemists and analysts in academia and industry, especially those engaged in the synthesis and analysis of organic compounds including drugs, drug intermediates, agrochemicals, polymers and dyes.
(source: Nielsen Book Data)

• Synthesis Pathways to Erythrina Alkaloids and Erythrina Type Compounds.- The Trichothecenes and Their Biosynthesis.- Melanin, Melanogenesis, and Vitiligo.
• (source: Nielsen Book Data)

The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question.
(source: Nielsen Book Data)

• Struktur, Darstellung und Reaktionen von Cyclopolyphosphinen
• Elektrophile Substitutionen bei quecksilberorganischen Verbindungen
• Im Steinkohlenteer nachgewiesene organische Verbindungen.

• Questions.- Answers.
• (source: Nielsen Book Data)

This workbook in stereochemistry is designed for students, lecturers and scientists in chemistry, pharmacy, biology and medicine who deal with chiral chemical compounds and their properties. It serves as a supplement to textbooks and seminars and thus provides selected examples for students to practice the use of the conventions and terminology for the exact three-dimensional description of chemical compounds. It contains 191 problems with extended solutions.
(source: Nielsen Book Data)

• What is a Supermolecule? -Its Origin, History and, Future.- Chemistry of Molecular Recognition -A Host Molecule Can Recognize its Guest Molecule.- Topology of Molecules -Formative Arts in Supramolecular Chemistry.- Supramolecular Assembly -Self-Organization of Molecules.- Supermolecules in Future Technology -Molecular Device and Nanotechnology.- Biological Supermolecules-Interface with Biology.
• (source: Nielsen Book Data)

The fundamentals of "supramolecular chemistry" to the latest developments on the subject are covered by this book. It sets out to explain the topic in a relatively easy way. The basic concepts of molecular recognition chemistry are included. Molecules with fascinating shapes and functions such as fullerenes, carbon nanotubes, dendrimers, rotaxane, and catenane, and molecular assemblies are also explained. Thereafter applications of supermolecules to nanotechnology are introduced with many examples of molecular devices. The last part of the book describes biological supermolecules and their mimics. Though simply explained undergraduate and graduate students in Chemistry will be able to use aspects of this work as an advanced textbook.
(source: Nielsen Book Data)

• 1 Introduction
• 2 Photocatalysis: The Principles
• 3 Practical Aspects of Photocatalysis
• 4 Photocatalytic Oxidative C-C Bond Formation
• 5 Decarboxylative Coupling Reactions
• 6 Proton-Coupled Electron Transfer
• 7 Organocatalysis with Amines in Photocatalysis
• 8 Copper-Based Photocatalysts for Visible-Light-Mediated Organic Transformations
• 9 Gold in Photocatalysis
• 10 Palladium in Photocatalysis
• 11 Nickel in Photocatalysis
• 12 Acridinium Dyes and Quinones in Photocatalysis
• 13 Flavins in Photocatalysis
• 14 Organic Dyes in Photocatalytic Reductive C-H Arylations
• 15 Silicates in Photocatalysis
• 16 Photocatalytic Cycloadditions
• 17 Photocatalytic Carbon-Heteroatom Bond Formation
• 18 Photocatalytic Introduction of Fluorinated Groups
• 19 Heterogeneous Photocatalysis in Organic Synthesis
• 20 Photocatalysis in the Pharmaceutical Industry.
• (source: Nielsen Book Data)

The field of photocatalysis has developed rapidly over the last decade and it is time to clarify its impact on organic synthesis. This volume is an opportunity to provide the defining and current reference work for this field. A primary objective is to collect together the most useful, practical, and reliable methods for photocatalysis and to introduce them to a larger audience. The fundamental concepts of photophysics are introduduced and laboratory set-ups are described, enabling newcomers to the field to instantly apply these new tools in synthesis. Rather than aiming for comprehensive coverage, solutions for challenging transformations in synthesis applying visible light and suitable dyes are presented. A team of pioneers and leaders in the field has been assembled, who discuss both the practical and conceptual aspects of this rapidly growing field. Scope, limitations, and mechanism of the reactions are covered and key experimental procedures are included.
(source: Nielsen Book Data)

• A review of general chemistry : electrons, bonds, and molecular properties
• Molecular representations
• Acids and bases
• Alkanes and cycloalkanes
• Stereoisomerism
• Chemical reactivity and mechanisms
• Alkyl halides : nucleophilic substitution and elimination reactions
• Addition reactions of alkenes
• Alkynes
• Radical reactions
• Synthesis
• Alcohols and phenols
• Ethers and epoxides; thiols and sulfides
• Infrared spectroscopy and mass spectrometry
• Nuclear magnetic resonance spectroscopy
• Conjugated pi systems and pericyclic reactions
• Aromatic compounds
• Aromatic substitution reactions
• Aldehydes and ketones
• Carboxylic acids and their derivatives
• Alpha carbon chemistry : enols and enolates
• Amines
• Introduction to organometallic compounds
• Carbohydrates
• Amino acids, peptides, and proteins
• Lipids
• Synthetic polymers.

Organic Chemistry, 3rd Edition is not merely a compilation of principles, but rather, it is a disciplined method of thought and analysis. Success in organic chemistry requires mastery in two core aspects: fundamental concepts and the skills needed to apply those concepts and solve problems. Readers must learn to become proficient at approaching new situations methodically, based on a repertoire of skills. These skills are vital for successful problem solving in organic chemistry. Existing textbooks provide extensive coverage of, the principles, but there is far less emphasis on the skills needed to actually solve problems.
(source: Nielsen Book Data)

• Electrons, Bonds, and Molecular Properties
• Molecular Representations
• Acids and Bases
• Alkanes and Cycloalkanes
• Stereoisomerism
• Chemical Reactivity and Mechanisms
• Alkyl Halides: Nucleophilic Substitution and Elimination Reactions
• Addition Reactions of Alkenes
• Alkynes
• Radical Reactions
• Synthesis
• Alcohols and Phenols
• Ethers and Epoxides; Thiols and Sulfides
• Infrared Spectroscopy and Mass Spectrometry
• Nuclear Magnetic Resonance Spectroscopy
• Conjugated Pi Systems and Pericyclic Reactions
• Aromatic Compounds
• Aromatic Substitution Reactions
• Aldehydes and Ketones
• Carboxylic Acids and Their Derivatives
• Alpha Carbon Chemistry: Enols and Enolates
• Amines
• Introduction to Organometallic Compounds
• Carbohydrates
• Amino Acids, Peptides, and Proteins
• Lipids
• Synthetic Polymers.

• Isolation and Identification of naturally-occurring imides (Includes Review of Techniques and Sources in the Isolation of Imide Natural Products)
• Total Synthesis of Imide Natural Products (Review and Critique of Naturally-occurring Imide Total Synthesis).
• (source: Nielsen Book Data)

Imides: Medicinal, Agricultural, Synthetic Applications and Natural Products Chemistry provides a comprehensive overview of imides being developed as pharmaceuticals or experimental therapeutics. Featuring a diverse range of experts in the field of imides, each chapter reviews the state-of-the-art, including the isolation and identification of naturally-occurring imides, as well as the total synthesis of imide natural products. As there is a need for a comprehensive review of imides as a class of naturally-occurring, biologically active molecules, this book will be invaluable to those in pharmaceuticals, academia, and anyone looking for clinical applications.
(source: Nielsen Book Data)

• Prologue
• Silence
• Movement 1, Earth : carbon, the element of crystals
• Movement 2, Air : carbon, the element of cycles
• Movement 3, Fire : carbon, the element of stuff
• Movement 4, Water : carbon, the element of life
• Finale : earth, air, fire, and water.

Carbon is everywhere: in the paper of this book and the blood of our bodies. It's with us from beginning to end, present in our baby clothes and coffin alike. We live on a carbon planet, and we are carbon life. No other element is so central to our well-being; yet, when missing or misaligned, carbon atoms can also bring about disease and even death. At once ubiquitous and mysterious, carbon holds the answers to some of humanity's biggest questions. Where did Earth come from? What will ultimately become of it-and of us? With poetic storytelling, earth scientist Robert M. Hazen explores the universe to discover the past, present, and future of life's most essential element. We're not only "made of star stuff, " as Carl Sagan famously observed, but "Big Bang stuff, " too. Hazen reveals that carbon's grand symphony began with a frenzied prelude shortly after the dawn of creation, bringing new attention to the tiny number of Big Bang-created carbon atoms that often get overlooked. In minutes, violently colliding protons and neutrons improbably formed the first carbon atoms, which can still be found within our bodies. His book then unfolds in four movements, building momentum as he explores carbon as the element of Earth, Air, Fire, and Water. He visits the famed volcanic crater Solfatara di Pozzuoli near Naples, where venting carbon dioxide and other noxious fumes condense into beautiful crystals. He climbs the cliffs of the Scottish Highlands and delves deep into the precious-metal mines of Namibia, journeying toward Earth's mysterious core in search of undocumented carbon structures. Hazen often asks us to pause and consider carbon's role in climate change and what we can do about it, for our lives and this element are inextricably intertwined. With prose that sparkles like a diamond, Symphony in C tells the story of carbon, in which we all have a part.
(source: Nielsen Book Data)

• 1 A Review of General Chemistry: Electrons, Bonds, and Molecular Properties. 2 Molecular Representations. 3 Acids and Bases. 4 Alkanes and Cycloalkanes. 5 Stereoisomerism. 6 Chemical Reactivity and Mechanisms. 7 Substitution Reactions. 8 Alkenes: Structure and Preparation via Elimination Reactions. 9 Addition Reactions of Alkenes. 10 Alkynes. 11 Radical Reactions. 12 Synthesis. 13 Alcohols and Phenols. 14 Ethers and Epoxides
• Thiols and Sulfides. 15 Infrared Spectroscopy and Mass Spectrometry. 16 Nuclear Magnetic Resonance Spectroscopy. 17 Conjugated Pi Systems and Pericyclic Reactions. 18 Aromatic Compounds. 19 Aromatic Substitution Reactions. 20 Aldehydes and Ketones. 21 Carboxylic Acids and Their Derivatives. 22 Alpha Carbon Chemistry: Enols and Enolates. 23 Amines. 24 Carbohydrates. 25 Amino Acids, Peptides, and Proteins. 26 Lipids. 27 Synthetic Polymers. Glossary A-1. Credits A-12. Index. I-.
• (source: Nielsen Book Data)

Students often say, "I studied 40 hours for this exam and I still didn't do well. Where did I go wrong?" Most instructors hear this complaint every year. In many cases, it is true that the student invested countless hours, only to produce abysmal results. Often, inefficient study habits are to blame. The important question is: why do so many students have difficulty preparing themselves for organic chemistry exams? There are certainly several factors at play here, but perhaps the most dominant factor is a fundamental disconnect between what students learn and the tasks expected of them. To address the disconnect in organic chemistry instruction, David Klein has developed a textbook that utilizes a skills-based approach to instruction. The textbook includes all of the concepts typically covered in an organic chemistry textbook, but special emphasis is placed on skills development to support these concepts. This emphasis upon skills development will provide students with a greater opportunity to develop proficiency in the key skills necessary to succeed in organic chemistry. As an example, resonance structures are used repeatedly throughout the course, and students must become masters of resonance structures early in the course. Therefore, a significant portion of chapter 1 is devoted to drawing resonance structures. Two chapters (6 and 12) are devoted almost entirely to skill development. Chapter 6 emphasizes skills that are necessary for drawing mechanisms, while chapter 12 prepares the student for proposing syntheses. In addition, each chapter contains numerous Skillbuilders, each of which is designed to foster a specific skill. Each skillbuildercontains three parts: 1. Learn the Skill: a solved problem that demonstrates a particular skill; 2. Practice the Skill: numerous problems (similar to the solved problem) that give the students an opportunity to practice and master the skill; 3. Apply the Skill: one or two more-challenging problems in which the student must apply the skill in a slightly different environment. These problems include conceptual, cumulative, and applied problems that encourage students to think out of the box. Sometimes problems that foreshadow concepts introduced in later chapters are also included. All SkillBuilders are visually summarized at the end of each chapter (Skillbuilder review), followed by a list of suggested in-chapter and end-of-chapter practice problems.
(source: Nielsen Book Data)

• The FUTURE Program: Engaging Underserved Populations through Early Research Experiences / Reig, Amanda J., Department of Chemistry, Ursinus College, Collegeville, Pennsylvania 19460, United States; Goddard, Kathryn A., Department of Biology, Ursinus College, Collegeville, Pennsylvania 19460, United States; Kohn, Rebecca E., Department of Biology, Ursinus College, Collegeville, Pennsylvania 19460, United States, Present Address: College of Arts & Sciences, Arcadia University, Glenside, Pennsylvania 19038, United States; Jaworski, Leslie, Department of Psychology, Grinnell College, Grinnell, Iowa 50112, United States; Lopatto, David, Department of Psychology, Grinnell College, Grinnell, Iowa 50112, United States / http://dx.doi.org/10.1021/bk-2018-1275.ch001
• Four-Year Research Engagement (FYRE) Program at the University of Oklahoma: Integrating Research in Undergraduate Curriculum / Kothapalli, Naga Rama / http://dx.doi.org/10.1021/bk-2018-1275.ch002
• Another Round of Whiskey for the House: Community College Students Continue Research on Experimental New Flavors of Whiskey / Silvestri, Regan / http://dx.doi.org/10.1021/bk-2018-1275.ch003
• Transforming Second Semester Organic Chemistry Laboratory into a Semester Long Undergraduate Research Experience / Carr, Andrew J.; Felix, Ryan J.; Gould, Stephanie L. / http://dx.doi.org/10.1021/bk-2018-1275.ch004
• Embedded Research in a Lower-Division Organic Chemistry Lab Course / Silverberg, Lee J., Pennsylvania State University, Schuylkill Campus, 200 University Drive, Schuylkill Haven, Pennsylvania 17972, United States; Tierney, John, Pennsylvania State University, Brandywine Campus, 25 Yearsley Mill Road, Media, Pennsylvania 19063, United States; Cannon, Kevin C., Pennsylvania State University, Abington Campus, 1600 Woodland Road, Abington, Pennsylvania 19001, United States / http://dx.doi.org/10.1021/bk-2018-1275.ch005
• Developing an Integrated Research-Teaching Model / Bachman, Robert E. / http://dx.doi.org/10.1021/bk-2018-1275.ch006
• Theory and Experiment Laboratory: Modeling the Research Experience in an Upper-Level Curricular Laboratory / Gourley, Bridget L. / http://dx.doi.org/10.1021/bk-2018-1275.ch007
• Integrating Research into the Curriculum: A Low-Cost Strategy for Promoting Undergraduate Research / Hati, Sanchita; Bhattacharyya, Sudeep / http://dx.doi.org/10.1021/bk-2018-1275.ch008
• Peptidomimetics from the Classroom to the Lab: Successful Research Outcomes from an "Upper-Level" Class at a Primarily Undergraduate Institution / Guarracino, Danielle A. / http://dx.doi.org/10.1021/bk-2018-1275.ch009
• Translation of Chemical Biology Research into the Biochemistry Laboratory: Chemical Modification of Proteins by Diethylpyrocarbonate / Hunsicker-Wang, Laura M., Department of Chemistry, Trinity University, San Antonio, Texas 78212, United States; Konkle, Mary E., Department of Chemistry, Ball State University, Muncie, Indiana 47306, United States / http://dx.doi.org/10.1021/bk-2018-1275.ch010
• Leveraging Student Interest in Environmental Topics for Undergraduate Research in an Interdisciplinary Environmental Research Cluster / Khan, Neelam; Park, Sang H.; Pursell, David P.; Zimmermann, Kathryn / http://dx.doi.org/10.1021/bk-2018-1275.ch011
• Overview of a Flexible Curriculum and the Impact on Undergraduate Research / Gourley, Bridget L. / http://dx.doi.org/10.1021/bk-2018-1275.ch012
• Transformative Impact of a Comprehensive Undergraduate Research Program on the Department of Chemistry at the University of North Carolina Asheville / Holmes, Bert E.; Wolfe, Amanda L.; Wasileski, Sally A.; Heard, George L. / http://dx.doi.org/10.1021/bk-2018-1275.ch013
• Leveraging NSF-CREST Center Funding To Support Undergraduate Research at Multiple Hispanic Serving/Minority Institutions / Cousins, Kimberley R., Department of Chemistry and Biochemistry, California State University San Bernardino, 5500 University Parkway, San Bernardino, California 92407, United States; Usher, Timothy, Department of Physics, California State University San Bernardino, 5500 University Parkway, San Bernardino, California 92407, United States; Smith, Douglas C., Department of Chemistry and Biochemistry, California State University San Bernardino, 5500 University Parkway, San Bernardino, California 92407, United States; Zhang, Renwu John, Department of Chemistry and Biochemistry, California State University San Bernardino, 5500 University Parkway, San Bernardino, California 92407, United States; Dixon, Paul K., Department of Physics, California State University San Bernardino, 5500 University Parkway, San Bernardino, California 92407, United States; Callori, Sara, Department of Physics, California State University San Bernardino, 5500 University Parkway, San Bernardino, California 92407, United States / http://dx.doi.org/10.1021/bk-2018-1275.ch014
• Institutionalizing Undergraduate Research and Scaffolding Undergraduate Research Experiences in the STEM Curriculum / Malachowski, Mitch, Department of Chemistry, University of San Diego, 5998 Alcalá Park, San Diego, California 92110, United States; Osborn, Jeffrey M., School of Science, The College of New Jersey, 2000 Pennington Road, Ewing, New Jersey, 08628-0718, United States; Karukstis, Kerry K., Department of Chemistry, Harvey Mudd College, 301 Platt Boulevard, Claremont, California 91711, United States; Kinzie, Jillian, Center for Postsecondary Research, Indiana University School of Education, 1900 East Tenth Street, Bloomington, Indiana 47406-7512, United States; Ambos, Elizabeth L., Council on Undergraduate Research, 734 15th St NW, Suite 850, Washington, DC 20005, United States / http://dx.doi.org/10.1021/bk-2018-1275.ch015
• Engaging Early-Career Students in Research Using a Tiered Mentoring Model / Hayes, Sarah M. / http://dx.doi.org/10.1021/bk-2018-1275.ch016
• Best Practices in Mentoring Undergraduate Researchers for Placement in an International Setting / Goeltz, J. C., School of Natural Sciences, California State University, Monterey Bay, Seaside, California 93955, United States; Duran, R. S., Office of Research Engagement and Gordon A Cain Center for STEM Literacy, Louisiana State University, Baton Rouge, Louisiana 70803, United States / http://dx.doi.org/10.1021/bk-2018-1275.ch017
• Assessing Undergraduate Research in Chemistry / Jones, Rebecca M. / http://dx.doi.org/10.1021/bk-2018-1275.ch018
• Senior Undergraduate Research and Assessment at Florida Southern College / Lee, Deborah Bromfield; Le, An-Phong / http://dx.doi.org/10.1021/bk-2018-1275.ch019
• Implementing Best Practices to Advance Undergraduate Research in Chemistry / Jones, Rebecca M. / http://dx.doi.org/10.1021/bk-2018-1275.ch020
• Editors' Biographies / http://dx.doi.org/10.1021/bk-2018-1275.ot001

The aim of this volume is to share a collection of best practices currently employed by faculty and administrators to support and expand undergraduate research in chemistry at their colleges or universities. This symposium helps fill the gap between generalized or holistic assessments and individual classroom/laboratory innovations, which can serve as models for adoption. The book is divided into four parts: Early Career Experiences, Upper Division Opportunities, Program and Curricular Reform, and Mentoring and Assessment. Overall, this volume provides a snapshot of curricular and programmatic best practices in engaging a broad spectrum of students in undergraduate research.
(source: Nielsen Book Data)

• Eye Tracking as a Research Tool: An Introduction / Cullipher, Steven, Science and Mathematics Department, Massachusetts Maritime Academy, Buzzards Bay, Massachusetts 02532, United States; Hansen, Sarah J. R., Department of Chemistry, Columbia University, New York, New York 10027, United States; VandenPlas, Jessica R., Department of Chemistry, Grand Valley State University, Allendale, Michigan 49401, United States / http://dx.doi.org/10.1021/bk-2018-1292.ch001
• Eye Tracking in Chemistry Education Research: Study Logistics / Hansen, Sarah J. R., Department of Chemistry, Columbia University, New York, New York 10027, United States; VandenPlas, Jessica R., Department of Chemistry, Grand Valley State, Allendale, Michigan 49401, United States / http://dx.doi.org/10.1021/bk-2018-1292.ch002
• What They See Impacts the Data You Get: Selection and Design of Visual Stimuli / Havanki, Katherine L., Department of Chemistry, The Catholic University of America, Washington, DC, 20064, United States; Hansen, Sarah J. R., Department of Chemistry, Columbia University, New York, New York 10027, United States / http://dx.doi.org/10.1021/bk-2018-1292.ch003
• Using Fixations To Measure Attention / Cullipher, Steven, Science and Mathematics Department, Massachusetts Maritime Academy, Buzzards Bay, Massachusetts 02532, United States; VandenPlas, Jessica R., Department of Chemistry, Grand Valley State University, Allendale, Michigan 49401, United States / http://dx.doi.org/10.1021/bk-2018-1292.ch004
• Sequence Analysis: Use of Scanpath Patterns for Analysis of Students' Problem-Solving Strategies / Day, Elizabeth L., Department of Chemistry, University of Georgia, Athens, Georgia 30602, United States; Tang, Hui, Department of Chemistry, University of Georgia, Athens, Georgia 30602, United States; Kendhammer, Lisa K., Department of Chemistry and Biochemistry, California State University, Chico, California 95929, United States; Pienta, Norbert J., Department of Chemistry, University of Georgia, Athens, Georgia 30602, United States / http://dx.doi.org/10.1021/bk-2018-1292.ch005
• Advanced Methods for Processing and Analyzing Eye-Tracking Data Using R / Tang, Hui; Pienta, Norbert J. / http://dx.doi.org/10.1021/bk-2018-1292.ch006
• Using Multiple Psychophysiological Techniques To Triangulate the Results of Eye-Tracking Data / Cortes, Kimberly Linenberger, Department of Chemistry & Biochemistry, Kennesaw State University, 370 Paulding Ave. NW, Kennesaw, Georgia 30144, United States; Kammerdiener, Kimberly, Department of Chemistry & Biochemistry, Kennesaw State University, 370 Paulding Ave. NW, Kennesaw, Georgia 30144, United States; Randolph, Adriane, Department of Information Systems, Kennesaw State University, 560 Parliament Garden Way NW, Kennesaw, Georgia 30144, United States / http://dx.doi.org/10.1021/bk-2018-1292.ch007
• Beyond Gaze Data: Pupillometry as an Additional Data Source in Eye Tracking / Karch, Jessica M. / http://dx.doi.org/10.1021/bk-2018-1292.ch008
• Coupling Eye Tracking with Verbal Articulation in the Evaluation of Assessment Materials Containing Visual Representations / Reed, Jessica J., Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States; Schreurs, David G., Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States; Raker, Jeffrey R., Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States; Murphy, Kristen L., Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States / http://dx.doi.org/10.1021/bk-2018-1292.ch009
• Studying the Language of Organic Chemistry: Visual Processing and Practical Considerations for Eye-Tracking Research in Structural Notation / Havanki, Katherine L. / http://dx.doi.org/10.1021/bk-2018-1292.ch010
• Editors' Biographies / http://dx.doi.org/10.1021/bk-2018-1292.ot001

The idea for an ACS symposium series for eye tracking started to form in the summer of 2015. Each of the editors had experience with eye tracking from our dissertation research and upon further discussion, discovered they all had the same questions: What type of eye tracker should be used? What types of research questions can eye tracking answer? What should be considered concerning experimental design? How could the results be analyzed in a meaningful way? With no clear help from the existing chemistry education research (CER) literature, the editors had to expand their reading to the fields of psychology, consumer analysis, and product design to find suitable answers. When they spoke with chemistry education researchers who were interested in eye tracking, they discovered these same questions were prevalent among them as well; and often, they did not even know where to start. At that point, they decided that an eye-tracking guidebook aimed at chemistry education researchers could be a valuable resource. This book is not intended to be a review of eye tracking in CER literature; rather, it is meant to be a tool to help answer the same questions the editors had when they started out in the field. The editors also hope that those with some experience in eye tracking will find among these pages ideas they had not considered applying to their research, but that will be valuable to them moving forward.
(source: Nielsen Book Data)

• Introduction to Raman Spectroscopy in the Undergraduate Curriculum / Hamann, Christian S.; Sonntag, Matthew D. / http://dx.doi.org/10.1021/bk-2018-1305.ch001
• Investigating the Similarities and Differences among UV/Vis, Infrared, Fluorescence, and Raman Spectroscopies through Discussion of Light-Matter Interactions / Wiester, Julia B. / http://dx.doi.org/10.1021/bk-2018-1305.ch002
• Connecting Organic and Physical Chemistry Students with Raman Spectroscopy / Hantz, Eric R.; Sonntag, Matthew D.; Hamann, Christian S. / http://dx.doi.org/10.1021/bk-2018-1305.ch003
• Implementation of Raman Spectroscopy in an Undergraduate Forensic Chemistry Course / Elkins, Kelly M., Chemistry Department, Towson University, 8000 York Road, Towson, Maryland 21252, United States; Carroll, Robin, Chemistry Department, Towson University, 8000 York Road, Towson, Maryland 21252, United States / http://dx.doi.org/10.1021/bk-2018-1305.ch004
• Analysis of Over-the-Counter Drugs Using Raman Spectroscopy / Mojica, Elmer-Rico E., Department of Chemistry and Physical Sciences, Pace University, New York, New York 10038, United States; Zapata, Jahaira, Department of Chemistry and Physical Sciences, Pace University, New York, New York 10038, United States; Vedad, Jayson, Department of Chemistry, York College and the Institute for Macromolecular Assemblies of the City University of New York, Jamaica, New York 11451, United States, Ph.D. Programs in Chemistry and Biochemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States; Desamero, Ruel Z. B., Department of Chemistry, York College and the Institute for Macromolecular Assemblies of the City University of New York, Jamaica, New York 11451, United States, Ph.D. Programs in Chemistry and Biochemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States; Dai, Zhaohua, Department of Chemistry and Physical Sciences, Pace University, New York, New York 10038, United States / http://dx.doi.org/10.1021/bk-2018-1305.ch005
• Structural, Vibrational, and pK a Determination of Carboxylic Acids Using DFT Calculations and Raman Spectroscopy: An Instrumental Analysis Laboratory / De la Rosa, Gabriela Arias, Department of Chemistry, York College and Institute for Macromolecular Assemblies of the City University of New York, Jamaica, New York 11451, United States, PhD Programs in Chemistry and Biochemistry, Graduate Center of the City University of New York, New York, New York 10016, United States; Zheng, Lucy Chou, Department of Chemistry, York College and Institute for Macromolecular Assemblies of the City University of New York, Jamaica, New York 11451, United States; Vedad, Jayson, Department of Chemistry, York College and Institute for Macromolecular Assemblies of the City University of New York, Jamaica, New York 11451, United States, PhD Programs in Chemistry and Biochemistry, Graduate Center of the City University of New York, New York, New York 10016, United States; Desamero, Ruel Z. B., Department of Chemistry, York College and Institute for Macromolecular Assemblies of the City University of New York, Jamaica, New York 11451, United States, PhD Programs in Chemistry and Biochemistry, Graduate Center of the City University of New York, New York, New York 10016, United States / http://dx.doi.org/10.1021/bk-2018-1305.ch006
• Development of a Physical Chemistry Laboratory Experiment To Explore Vibrational Spectroscopy Selection Rules / Adams, William; Sonntag, Matthew D. / http://dx.doi.org/10.1021/bk-2018-1305.ch007
• Quantitative Analysis of Xylene Mixtures Using a Handheld Raman Spectrometer / Vedad, Jayson, Department of Chemistry, York College and the Institute for Macromolecular Assemblies of the City University of New York, Jamaica, New York 11451, United States, Ph.D. Programs in Chemistry and Biochemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States; Reilly, Lauren, Department of Chemistry and Physical Sciences, Pace University, New York, New York 10038, United States; Desamero, Ruel Z. B., Department of Chemistry, York College and the Institute for Macromolecular Assemblies of the City University of New York, Jamaica, New York 11451, United States, Ph.D. Programs in Chemistry and Biochemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States; Mojica, Elmer-Rico E., Department of Chemistry and Physical Sciences, Pace University, New York, New York 10038, United States / http://dx.doi.org/10.1021/bk-2018-1305.ch008
• Exploring the Figures of Merit of Surface-Enhanced Raman Spectroscopy / Shah, Nilam C.; Murphy, Ian; Widmer, Alexandra / http://dx.doi.org/10.1021/bk-2018-1305.ch009
• Research with Undergraduates at the Intersection of Chemistry and Art: Surface-Enhanced Raman Scattering Studies of Oil Paintings / Burke, Shelle N., Department of Chemistry, College of William & Mary, P.O. Box 8795, Williamsburg, Virginia 23187-8795, United States; Farling, Carolyn G., Department of Chemistry, College of William & Mary, P.O. Box 8795, Williamsburg, Virginia 23187-8795, United States; Svoboda, Shelley A., Department of Conservation, Colonial Williamsburg Foundation, P.O. Box 1776, Williamsburg, Virginia 23187-1776, United States; Wustholz, Kristin L., Department of Chemistry, College of William & Mary, P.O. Box 8795, Williamsburg, Virginia 23187-8795, United States / http://dx.doi.org/10.1021/bk-2018-1305.ch010
• Solvent Sensitivity of the −C≡N Group: A Raman Spectroscopic Study / Mojica, Elmer-Rico E., Department of Chemistry and Physical Sciences, Pace University, New York, New York 10038, United States; Abbas, Nadia, Department of Chemistry and Physical Sciences, Pace University, New York, New York 10038, United States; Wyan, Lyric O., Department of Chemistry and Physical Sciences, Pace University, New York, New York 10038, United States; Vedad, Jayson, Department of Chemistry, York College and the Institute for Macromolecular Assemblies of the City University of New York, Jamaica, New York 11451, United States, Ph.D. Programs in Chemistry and Biochemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States; Desamero, Ruel Z. B., Department of Chemistry, York College and the Institute for Macromolecular Assemblies of the City University of New York, Jamaica, New York 11451, United States, Ph.D. Programs in Chemistry and Biochemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States / http://dx.doi.org/10.1021/bk-2018-1305.ch011
• Integration of Raman Spectroscopy in Undergraduate Instruction and Research at Pace University / Dai, Zhaohua; Javornik, Alexis; Sobolewski, Claudia; Batte, Tabitha; Viola, John; Rizzo, JamieLee; Athanasopolous, Demosthenes; Mojica, Elmer-Rico E. / http://dx.doi.org/10.1021/bk-2018-1305.ch012
• Editor's Biography / http://dx.doi.org/10.1021/bk-2018-1305.ot001

It has been nearly a century since Raman scattering was first experimentally observed. In current times, Raman spectroscopy has emerged as a versatile and powerful tool in a diverse set of scientific fields. Its implementation has grown markedly in the past 20 years due to technological advances and affordability of instrumentation. As such, more and more undergraduate institutions have acquired Raman instrumentation, and faculty from a variety of disciplines have begun to utilize the technique. This has resulted in an increased number of students gaining hands-on experience with Raman spectroscopy. As its use has grown, curricular pedagogies that utilize Raman spectroscopy to investigate interesting scientific problems have continually been developed, implemented, and publicized. Given the recent developments in the field and inspired by similar symposia on nuclear magnetic resonance and x-ray crystallography at recent ACS meetings, the editors developed a symposium titled "Engaging Undergraduates with Raman Spectroscopy." This symposium was held at the National ACS meeting held in Washington, D.C., in 2017. It generated strong interest, and the quality of presentation and breadth of knowledge displayed by the presenters was indicative of the continual pedagogical innovation of Raman spectroscopy in the undergraduate curriculum. The collection of chapters herein is based on the symposium, and several contributors to this book were its invited speakers. One of the main objectives of this volume is to convey the ideas discussed at the symposium to the broader scientific community. Our hope is that readers not only learn a great deal about the uses of Raman spectroscopy but also are stimulated to innovate new ways to incorporate Raman spectroscopy into the undergraduate curriculum.
(source: Nielsen Book Data)

• Using Computational Methods To Teach Chemical Principles: Overview / Grushow, Alexander, Department of Chemistry, Biochemistry & Physics, Rider University, Lawrenceville, New Jersey 08648, United States; Reeves, Melissa S., Department of Chemistry, Tuskegee University, Tuskegee, Alabama 36088, United States / http://dx.doi.org/10.1021/bk-2019-1312.ch001
• Molecular Dynamics Simulations in First-Semester General Chemistry: Visualizing Gas Particle Motion and Making Connections to Mathematical Gas Law Relationships / Bruce, C. D. / http://dx.doi.org/10.1021/bk-2019-1312.ch002
• Using Electronic Structure Calculations To Investigate the Kinetics of Gas-Phase Ammonia Synthesis / Stocker, Kelsey M. / http://dx.doi.org/10.1021/bk-2019-1312.ch003
• Modeling Reaction Energies and Exploring Noble Gas Chemistry in the Physical Chemistry Laboratory / Phillips, James A. / http://dx.doi.org/10.1021/bk-2019-1312.ch004
• How Can You Measure a Reaction Enthalpy without Going into the Lab?: Using Computational Chemistry Data to Draw a Conclusion / Reeves, Melissa S., Department of Chemistry, Tuskegee University, Tuskegee, Alabama 36088, United States; Berghout, H. Laine, Department of Chemistry, Weber State University, Ogden, Utah 84408, United States; Perri, Mark J., Department of Chemistry, Sonoma State University, Rohnert Park, California 94928, United States; Singleton, Steven M., Chemistry Department, Coe College, Cedar Rapids, Iowa 52402, United States; Whitnell, Robert M., Department of Chemistry, Guilford College, Greensboro, North Carolina 27410, United States / http://dx.doi.org/10.1021/bk-2019-1312.ch005
• Process Oriented Guided Inquiry Learning Computational Chemistry Experiments: Revisions and Extensions Based on Lessons Learned from Implementation / Whitnell, Robert M., Department of Chemistry, Guilford College, Greensboro, North Carolina 27410, United States; Reeves, Melissa S., Department of Chemistry, Tuskegee University, Tuskegee, Alabama 36088, United States / http://dx.doi.org/10.1021/bk-2019-1312.ch006
• Chem Compute Science Gateway: An Online Computational Chemistry Tool / Perri, Mark J.; Akinmurele, Mary; Haynie, Matthew / http://dx.doi.org/10.1021/bk-2019-1312.ch007
• Using Computational Chemistry to Extend the Acetylene Rovibrational Spectrum to C2T2 / Martin, William R.; Ball, David W. / http://dx.doi.org/10.1021/bk-2019-1312.ch008
• Introducing Quantum Calculations into the Physical Chemistry Laboratory / DeVore, Thomas C. / http://dx.doi.org/10.1021/bk-2019-1312.ch009
• Learning by Computing: A First Year Honors Chemistry Curriculum / Sharma, Arun K.; Asirwatham, Lukshmi / http://dx.doi.org/10.1021/bk-2019-1312.ch010
• Integrating Computational Chemistry into an Organic Chemistry Laboratory Curriculum Using WebMO / Esselman, Brian J.; Hill, Nicholas J. / http://dx.doi.org/10.1021/bk-2019-1312.ch011
• Computational Narrative Activities: Combining Computing, Context, and Communication To Teach Chemical Concepts / Singleton, Steven M. / http://dx.doi.org/10.1021/bk-2019-1312.ch012
• Computational Chemistry as a Course for Students Majoring in the Sciences / Tribe, Lorena / http://dx.doi.org/10.1021/bk-2019-1312.ch013
• Beyond the Analytical Solution: Using Mathematical Software To Enhance Understanding of Physical Chemistry / McDonald, Ashley Ringer; Hagen, John P. / http://dx.doi.org/10.1021/bk-2019-1312.ch014
• A Lab Course in Computational Chemistry Is Not About Computers / Grushow, Alexander / http://dx.doi.org/10.1021/bk-2019-1312.ch015
• Discovery-Based Computational Activities in the Undergraduate Chemistry Curriculum / Kholod, Yana, Department of Chemistry and Physics, Monmouth University, 400 Cedar Avenue, West Long Branch, New Jersey 07764, United States; Kosenkov, Dmytro, Department of Chemistry and Physics, Monmouth University, 400 Cedar Avenue, West Long Branch, New Jersey 07764, United States / http://dx.doi.org/10.1021/bk-2019-1312.ch016
• Using the Hydrogen Bond as a Platform for the Enhancement of Integrative Learning / Price, Harry L. / http://dx.doi.org/10.1021/bk-2019-1312.ch017
• Editors' Biographies / http://dx.doi.org/10.1021/bk-2019-1312.ot001

While computational chemistry methods are usually a research topic of their own, even in the undergraduate curriculum, many methods are becoming part of the mainstream and can be used to appropriately compute chemical parameters that are not easily measured in the undergraduate laboratory. These calculations can be used to help students explore and understand chemical principles and properties. Visualization and animation of structures and properties are also aids in students' exploration of chemistry. This book will focus on the use of computational chemistry as a tool to teach chemical principles in the classroom and the laboratory.
(source: Nielsen Book Data)

Online resource for synthetic organic chemists which provides information about the most important and useful synthetic reactions, organized primarily by reaction type. Each major component contains a critical discussion of the featured type of reaction as well as a step-by-step guide to performing it. The online version of Organic Reactions has been a regularly updated online database since 2003 and is available as either an electronic major reference work (eMRW), or a fully-featured database product with a set of advanced tools for structure/sub-structure and reaction searching.

• Section i Ionic Liquids in Organic Catalysis
• Chapter 1 Task-Specific Ionic Liquids
• Ahmed Ali Hullio
• Chapter 2 Ionic Liquid-Supported Organocatalysts for Asymmetric
• Organic Synthesis
• Allan D. Headley
• Chapter 3 Organocatalysis Induced by the Anion of an Ionic
• Liquid: A New Strategy for Asymmetric Ion-Pair Catalysis
• Andreea R. Schmitzer
• Chapter 4 Imidazolium Hydroxides and Catalysis
• Cameron C. Weber
• Chapter 5 Organocatalysis of SN2 Reactions by Multifunctional
• Promotors: Ionic Liquids and Derivatives
• Sungyul Lee and Dong Wook Kim
• Chapter 6 Sustainable Organic Synthesis Using Ionic Liquids
• Toshiyuki Itoh and Toshiki Nokami
• Section ii Ionic Liquids in Biocatalysis
• and Biomass Processing
• Chapter 7 Biotransformations in Deep Eutectic Solvents
• Vicente Gotor-Fernandez and Caroline Emilie Paul
• Chapter 8 Ionic Liquids in Sustainable Carbohydrate Catalysis
• Pilar Hoyos, Cecilia Garcia-Oliva, and Maria J. Hernaiz
• Chapter 9 Sponge-Like Ionic Liquids for Clean Biocatalytic Processes
• Susana Nieto-Ceron, Elena Alvarez-Gonzalez,
• Juana M. Bernal, Antonio Donaire, and Pedro Lozano
• Chapter 10 Ionic Liquids for Biomass Processing
• Wei-Chien Tu and Jason P. Hallett
• Chapter 11 Membrane Technology for Catalytic Processes in Ionic Liquids
• J. Romero, R. Cabezas, C. Araya, and G. Merlet.
• (source: Nielsen Book Data)

Sustainable Catalysis in Ionic Liquids provides an up-to-date overview of the relatively underexplored area of the use of room temperature ionic liquids as organocatalysts for a range of organic reactions, including polymerizations. Using organic molecules to promote reactions is an attractive option as these organic molecules can be safer than metal-based options. However, it is still important to be able to recycle and reuse these organic promoters. Ionic liquids provide this opportunity.
(source: Nielsen Book Data)

• Frontmatter
• Preface
• Contents
• 1. Overview
• 2. Statistical Evaluation
• 3. Quality Control Strategies
• 4. Sampling of Organic Trace Contaminants
• 5. Sample Treatment Before Analysis
• 6. Enrichment and Sample Cleanup
• 7. Chromatography
• 8. Capillary Electrophoresis (CE)
• 9. Mass Spectrometry
• 10. Receptor-based Bioanalysis for Mass Screening
• 11. Selected Applications
• List of Abbreviations
• Index.

"Organic Trace Analysis" presents the basics of trace analysis, from sample preparation to the measurement: Students are introduced to statistical evaluation, quality control technologies, sampling and preparation of organic traces, as well as to enrichment and separation of samples. Spectroscopic techniques as chromatography, capillary electrophoresis, mass spectrometry, and receptor-based bioanalysis are presented in detail.
(source: Nielsen Book Data)

• Radical Substitution Reactions at the Saturated C Atom Nucleophilic Substitution Reactions at the Saturated C Atom Additions to the Olefinic C=C Double Bond Eliminations Substitution Reactions on Aromatic Compounds Nucleophilic Substitution Reactions (Except Through Enolates) on the Carboxyl Carbon Additions of Heteroatom Nucleophiles to Heterocumulenes Additions of Heteroatom Nucleophiles to Carbonyl Compounds and Their Secondary Reactions Addition of H Nucleophiles and Metal Organyls to Carbonyl Compounds Reaction of Ylides with Saturated or Unsaturated Carbonyl Compounds Chemistry of the Alkaline Earth Metal Enolates Rearrangements Thermal Cycloadditions Transition Metal-Mediated Alkenylations, Arylations and Alkynylations Oxidations and Reductions.
• (source: Nielsen Book Data)

A best-selling mechanistic organic chemistry text in Germany, this text's translation into English fills a long-existing need for a modern, thorough and accessible treatment of reaction mechanisms for students of organic chemistry at the advanced undergraduate and graduate level. Knowledge of reaction mechanisms is essential to all applied areas of organic chemistry; this text fulfills that need by presenting the right material at the right level.
(source: Nielsen Book Data)

• Part 1 Carbonyl Compounds
• Carbonyl Compounds in Context
• The Structure of the Carbonyl Group
• Nucleophilic Attack at the Carbonyl Group
• Conclusion
• Part 2 Synthetic Applications of Organometallic Compounds
• Organomagnesium Halides
• Organolithium and Organosodium Compounds
• Organocopper Compounds
• Review of the Reactivities of Organometallic Reagents
• Organoboron Compounds
• Part 3 Radical Reactions in Organic Synthesis
• Reactions of Radicals
• Radical-Radical Coupling Reactions (Radical Combinations)
• Radical Chain Reactions
• Radical Fragmentation Reactions
• An Application
• Part 4 Strategy and Methodology in Organic Synthesis
• Synthesis in Organic Chemistry
• Requirements for Synthesis
• Planning a Synthesis
• Simple Disconnections: C-X Bonds
• Simple Disconnections: C-C Bonds
• CD-ROM Activity
• Control in Synthesis
• Further Factors Affecting the Choice of a Synthetic Route
• Synthesis of a Drug
• Part 5 Synthesis and Biosynthesis: Terpenes and Steroids
• The Laboratory Synthesis of Monoterpenes
• A Biochemical Interlude
• The Synthesis of Terpenes in Living Systems
• The Chemistry of Terpene Biosynthesis
• From Triterpenes to Steroids
• Case Study: Polymer Chemistry.
• (source: Nielsen Book Data)

This book pursues possible strategies for synthesising mainly organic compounds, particularly those of interest to the health sector and related industries. Topics covered include addition reactions of aldehydes and ketones; the use of organometallic reagents to form carbon-carbon bonds (eg Grignard reagents); and radical reactions, including selectivity and chain reactions. Retrosynthetic analysis is introduced as a strategy for developing syntheses, along with biochemical pathways. Mechanism and Synthesis concludes with a Case Study on polymers, which demonstrates how chain reactions can be used to build up useful materials with specific properties, such as contact lenses. The Molecular World series provides an integrated introduction to all branches of chemistry for both students wishing to specialise and those wishing to gain a broad understanding of chemistry and its relevance to the everyday world and to other areas of science. The books, with their Case Studies and accompanying multi-media interactive CD-ROMs, will also provide valuable resource material for teachers and lecturers. (The CD-ROMs are designed for use on a PC running Windows 95, 98, ME or 2000.).
(source: Nielsen Book Data)

• Part 1 Crystals: Introduction
• Structures of Metals
• The Internal Structure of a Crystal
• Ionic Solids
• Ionic Radii
• Extended Covalent Structures
• Molecular Crystals
• Defects in Crystals
• Part 2 Molecular Shape: The Tetrahedral Carbon Atom
• Molecular Conformation
• The Representation of Molecules
• Constitutional (Structural) Isomerism
• Stereoisomers of Molecules containing Double Bonds
• Chirality
• Molecules with more than one Chiral Atom
• Stereochemistry of Saturated Ring Compounds
• Case Study: Liquid Crystals - The Fourth State of Matter.
• (source: Nielsen Book Data)

The three-dimensional aspects of molecular shape can be crucial to both properties and reactions. The Third Dimension explores the arrangements of atoms in molecules and in different types of solids. Initial chapters describe the common crystal structures and how they are related to close-packed arrangements of ions. Metallic, ionic, molecular and extended covalent crystals are covered; major types of crystal defects are also discussed. The book then introduces isomerism, and explores the stereochemical consequences of the tetrahedral carbon atom. Chirality is also investigated. The book concludes with a Case Study on Liquid Crystals, which describes structures, properties and applications. As visualisation in 3D is an important part of this book, the accompanying CD-ROMs provide video material, interactive questions and exercises using models to aid understanding of crystals, organic molecules and stereochemistry. All necessary programs are provided. The Molecular World series provides an integrated introduction to all branches of chemistry for both students wishing to specialise and those wishing to gain a broad understanding of chemistry and its relevance to the everyday world and to other areas of science. The books, with their Case Studies and accompanying multi-media interactive CD-ROMs, will also provide valuable resource material for teachers and lecturers. (The CD-ROMs are designed for use on a PC running Windows 95, 98, ME or 2000.).
(source: Nielsen Book Data)

• Volume 1. pt. I. Early studies
• pt. II. Electrophilic aromatic substitution
• pt. III. Friedel-Crafts chemistry
• pt. IV. Stable (persistent), long-lived carbocations : General aspects
• pt. V. Trivalent alkyl (cycloalkyl) cations (carbenium ions)
• pt. VI. [symbol] and [symbol]-delocalized carbocations
• pt. VII. Heteroatom and metal substituted carbocations
• pt. VIII. Carbodications
• pt. IX. Aromatic and homoaromatic cations and dications
• pt. X. Five and higher coordinate (nonclassical) carbonium ions: Controversy and significance
• pt. XI. Magic acid and superacid chemistry
• pt. XII. Solid superacid catalysis
• pt. XIII. From Kekule's four valent carbon to higher coordinate hypercarbon
• pt. XIV. Electrophilic chemistry of saturated hydrocarbons.

• Volume 2. pt. XVI. Oxonium, sulfonium, selenonium and telluronium ions
• pt. XVII. Azonium ions
• pt. XVIII. Halonium ions
• pt. XIX. Miscellaneous onium ions
• pt. XX. Gitonic onium di(poly)cations and superelectrophilic activation
• pt. XXI. Synthetic reagents, methods and reactions
• pt. XXII. Oxygenation and sulfuration
• pt. XXIII. Nitration and nitrosation chemistry
• pt. XXIV. Organofluorine chemistry
• pt. XXV. Organometallic chemistry
• pt. XXVI. Polymer chemistry
• pt. XXVII. New approaches to future hydrocarbon needs
• pt. XXVIII. Miscellaneous studies
• Monographs and books for reference and additional
• Curriculum vitae of George Andrew Olah
• Bibliography of George A. Olah
• Past and present graduate students
• Past and present postdoctoral and visiting scholars.

In the course of his distinguished career spanning about half a century, George A. Olah, winner of the 1994 Nobel Prize for Chemistry, has been exceedingly prolific and has published more than 1000 scientific papers and 15 books and holds more than 100 patents. This invaluable volume contains about 250 papers selected for their breadth and current importance.

• Abbreviations. Introduction. Graphical Abstracts of Reaction Numbers (RXN). Reactions Catalyzed by Palladium Complexes: Cross-Coupling of Organometallics with RX Derivatives. Cross-Coupling of Organometallicswith RCOX Derivatives. Cross-Coupling of Siloxycyclopropanes with RX and RCOX Derivatives. Cross-Coupling of Terminal Alkynes with RX Derivatives. Intermolecular HECK Reaction. Intramolecular HECK Reaction. Intramolecular Coupling of Di(Vinyl Halides). Tandem HECK-Anion Capture Process of Alkenes, Alkyenes, Alkynes, Allenes and Dienes. Tandem HECK-Anion Capture Process of Norbonene and Related Compounds. Tandem Arylsulfonation-Cyclization Process. Tandem Cyclization-Anion Capture (-Carbonylation) Processof Alkenes and Alkynes. Tandem Cyclization-Anion Capture (-Carbonylation) Process of Ene-Vinyl, Ene-Aryl, and Ene-Alkyl Halides. Tandem Cyclization-Anion Capture Process of Yne-Vinyl and Yne-Aryl Halides. Hydroarylation and Hydrovinylation of Alkenes andAlkynes. Reduction of Alkenes. Semihydrogenation of Alkynes and 1,3-Dienes. Hydroboration, Hydrogennyladon, Hydrosilylation and Hydrostannation of Alkynes, Allenes, Dienes, and Enynes. Hydroselenation of Alkynes. 1,4-Disilyation of Conjugated Enones. Hydrocarboxylation, Hydrocarboalkoxylation and Hydrocarboamination of Alkenes and Alkynes. Tandem Carbonylation-Arylation with Alkynes. 1,2-Dimetallation of Alkynes and Alkenes and Related Reactions. 1,2-Dimetallation of Isonitriles. 1,2-Dimetallation of Allenes. Coupling of Aryl Derivatives with Alkenes Involving a Pd(II) Catalyst. Homocoupling of Aryl and Vinyl Derivatives. Codimerization of Alkynes. Codimerization of Terminal Alkynes with Allenes. Codimerization of Alkynes and Allyl Halides. Cyclopropanation of Alkenes and 1,3-Dienes by Diazomethane. Rearrangement of (-Hydroxy Diazo Compounds. Substitution, Addition, and Elimination on Pro-(-Allyl Substrates. [3,3]-Sigmatropic Rearrangement and [1,3]-Shift on Allylic Derivatives. 1,3-Diene Monoepoxide Rearrangement. Ring Extension of Cyclobutane Derivatives. [3+2], [3+4], [3+6], [1+2] Cycloadditions. Intramolecular Ene-Like Reactions. Cyclization of Hexatrienolate Derivatives. Amination or Amidation of Alkenes. Alkoxylation of Alkenes and Alkynes. Acetalization of Alkenes. Allylic Acyloxylation of Cycloalkenes. Tandem Acyloxylation-Cyclization of 1,5-Dienes. Tandem Acycloxychlorination-Cyclization of 1,6-Dienes. 1,4-Acycloxychlorination of 1,3-Dienes. 1,4-Diacyloxylation of 1,3-Dienes and Related Reactions. Intramolecular Amination, Alkoxylation of Acyloxylation of Alkynes. Tandem Intramolecular Amination, Alkoxylation, or Acyloxylation-Allylation of Alkynes and Allenes. Tandem Intramolecular Amination, Alkoxylation, or Acyloxylation-Carbonylation of Alkynes. Intramolecular Amination or Alkoxylation of Alkenes. Tandem Intramolecular Amination or Alkoxylation-Carbonylation of Alkenes and Allenes. Reductive Cyclization with Diynes and Enynes. Cycloisomerization of Diynes and Enynes. Cycloaddition of Aziridines with Carbodiimides. Telomerization of 1,3-Dienes with Nucleophiles. WACKER Process. Preparation of Ketones from Alcohols or Derivatives via a (-Hydride Elimination. Preparation of ((-Unsaturated Carbonyl Derivatives via a (-Hydride Elimination. Preparation of (-Diketones Derivatives via an Oxidative Rearrangement of a Propargyl Acetate. Carbonylation. Isomerization of Alkynes. Addition of Thiols to Alkynes. Preparation of Allylic Acetates from Alkynes by Tandem Redox-Addition. Tandem Cyclization-Capture Process of Enynes. Aldol-Like Condensation of Enol Esters with Aldehydes. Addition of Fluoroalkyl Iodides to Alkenes or Alkynes via a Pd(I) Species. Intermolecular Tandem Carbonylation-Coupling-Cyclization Process of Aryl Halides with Terminal Alkynes.Intramolecular Coupling of Aryl Halides with Arenes. Tandem Intramolecular Alkoxylation-Vinylation of Alkenes. Carbonylative [2+2] Cycloaddition. Dicarboalkoxylation of Alkenes. Addition of Pronucleophiles on 1,3-Dienes or Allenes. Tandem Cycloisomerization-Cycloaddition of Dienynes with 1,3-Dienes via Metallodienes. Acylcyanation of Terminal Alkynes. 1,4-Carbochlorination of 1,3-Dienes. Tandem Chlorination-Cyclization and Tandem Chlorination-Carbonylation-Cyclization of 1,6-Enynes. Intramolecular Cyclocarbonylation of Alkenes. Abbreviations and Symbols. Notes. Subject Index.
• (source: Nielsen Book Data)

This comprehensive handbook will be an indispensable research tool for chemists. Handbook of Palladium Catalysed Organic Reactions provides a synoptic description of the main types of reactions which are catalyzed by Palladium and the mechanism which causes these reactions. Each reaction is presented in graphical form and classified according to the type of transformation involved. Other books covering the use of Palladium complexes as catalysts have been written, but the Handbook is the only to offer a synoptic view, showing the catalytic cycle of each reaction. This complete coverage provides the reader with a good understanding of the parameters involved. The tables included can be viewed from the point of view of the reagents, the product of the reaction, or the mechanism involved. The Handbook is a companion to the Database of Palladium Chemistry: Reactions andCatalytic Cycles, published on CD-ROM.
(source: Nielsen Book Data)

• Ch. 1. The origin and the nature of natural products / Raphael Ikan
• ch. 2. Plant-derived natural products in drug discovey and development: an overview / Mark Bahar [and others]
• ch. 3. Plant and brain cannabinoids: the chemistry of major new players in physiology / Lumir Hanuš and Raphael Mechoulam
• ch. 4. Natural products as biomarker tracers in environmental and geological processes / Bernd R.T. Simoneit
• ch. 5. Toxins of marine invertebrates and microorganisms / Yoel Kashman and Yehuda Benayahu
• ch. 6. Enantiomeric distribution of odorous oxygenated monoterpenes in aromatic plants / Uzi Ravid
• ch. 7. Recent trends of some natural sweet substances from plants / Bernard Crammer
• ch. 8. Natural products for pest management / Stephen O. Duke [and others]
• ch. 9. Natural products in mycelial microorganisms: impact of morphology / Sergei Braun
• ch. 10. Recent advances in the chemistry of insect pheromones / Mangesh J. Goundalkar and Francis X. Webster
• ch. 11. Nature derived antibiotics / Srinivas Kodali and Jun Wang
• ch. 12. Natural products and related compounds of realized and potential use in treating neurodegenerative disease / Peter J. Houghton and Melanie-Jayne Howes
• ch. 13. Phytotoxic compounds with calmodulin inhibitor properties from selected Mexican fungi and plants / Rachel Mata, Sergio-Martínez Luis and.

Contains specialized work that describes the chemistry of separate classes of compounds such as steroids, terpenes, alkaloids, sugars, carotenoids, fatty acids and so on. This work covers the following topics of natural products: cannabinoids, toxic constituents from marine sources, natural sweeteners, generation of wines, and more.

• Preface
• Chapter 1. The Birth of the Field of Organic Phosphorus Chemistry
• Chapter 2. The Pioneering Work of August Wilhelm Hofmann in Organophosphorus Chemistry
• Chapter 3. The Many Research Accomplishments of August Michaelis
• Chapter 4. The Contributions of Other Chemists, 1870-1900Appendix. Full Names of Journals CitedIndexPlease visit our website athttps://www.novapublishers.com/catalog/product_info.php?produc ts_id=50385.
• (source: Nielsen Book Data)

The nineteenth century saw the beginning and flourishing of the now huge and important field of organophosphorus chemistry. The first compound with a carbon-phosphorus bond was made in 1845, but the scope of this new field did not become apparent until the work of the famous August Wilhelm Hofmann spanning the years 1855-1873. It was only after that, that the field attracted the attention of other chemists. The most notable was August Michaelis who made many valuable contributions. By the end of the century, the field was well established and the way was clear for the dramatic growth in the twentieth century, especially the second half. Phosphorus can be found in various functional groups, and the discovery and description of these, and the development of still useful synthetic methods, are traced in this book.
(source: Nielsen Book Data)

• Volatile Organic Compounds Abatments: Hydrocarbons, Halogenated Compounds, HAP, and Others
• Diesel Oxidation Catalysts
• New Processes in Total Oxidation
• Plasma Catalysis
• Electrocatalysis
• Catalytic Selective Oxidation in the Gas and in the Liquid Phase: Principles and Applications
• Innovative Aspects
• Industrial Examples.
• (source: Nielsen Book Data)

This book offers a comprehensive overview of the most recent developments in both total oxidation and combustion and also in selective oxidation. For each topic, fundamental aspects are paralleled with industrial applications. The book covers oxidation catalysis, one of the major areas of industrial chemistry, outlining recent achievements, current challenges and future opportunities. One distinguishing feature of the book is the selection of arguments which are emblematic of current trends in the chemical industry, such as miniaturization, use of alternative, greener oxidants, and innovative systems for pollutant abatement. Topics outlined are described in terms of both catalyst and reaction chemistry, and also reactor and process technology.
(source: Nielsen Book Data)

• pt. I. In the beginning
• pt. II. Cis-elimination
• pt. III. Conformaational analysis
• pt. IV. Triterpenoid chemistry
• pt. V. Steroidal alkaloids
• pt. VI. Sesquiterpenoids caryophyllene
• pt. VII. Plant bitter principles
• pt. VIII. Fungal metabolites
• pt. IX. Biosynthesis of phenolic alkaloids
• pt. X. The invention of photochemical reactions
• pt. XI. Nitrite photolysis
• pt. XII. Thionobenzoate photolysis
• pt. XIII. Biosynthesis of steroids
• pt. XIV. Tetracycline
• pt. XV. Electrophilic fluorination
• pt. XVI. Synthesis of l[symbol]-hydroxy- and 1[symbol], 25-dihydroxy-vitamin D[symbol]
• pt. XVII. The chemistry of penicillin
• pt. XVIII. The synthesis of highly hindered olefins
• pt. XIX. Phenylseleninic anhydride and related oxidants
• pt. XX. Deoxygenation of alcohols by radical mechanisms
• pt. XXI. Radical-anion deoxygenation and radical deamination
• pt. XXII. Deoxygenation by-paths
• pt. XXIII. Radical decarboxylation: The chemistry of barton esters
• pt. XXIV. The steroidal side chain and related matters
• pt XXV. The chemistry of Bi[symbol] and related studies
• pt. XXVI. Gif oxidation chemistry
• pt. XXVII. Further collaborative research with Dr. S.D. Gero & his colleagues
• pt. XXVIII. And what remains?

This book is about the recognition of new principles in Organic Chemistry. It is also about the discovery and invention of Chemical Reactions. In addition, it deals with the determination of structure by chemical degradation during the epoch when physical methods were not well developed. Also presented are new reagents and new types of functional groups never seen in chemistry before. The overall aim of the collected papers is to show how thought can direct original research and to demonstrate how thought about old or new chemical facts can lead to originality. This is further illuminated by commentaries which Prof Barton has written to accompany these papers.
(source: Nielsen Book Data)

• Ether/or
• Springtime for chemistry?
• The education of Alexander Williamson
• Interpreting chemical atoms
• Williamson and Graham
• Grasping the ether
• The experimental dissection of organic molecules
• Excursus: isolated radicals?
• The spread of Williamsonian theory
• The architect of molecules
• The education of August Kekulé
• Kekulé in London
• Excursus: the road to Valence
• Molecular dreams
• Building an unseen structure
• The start of a teaching career
• Early work in Heidelberg
• The theory of polyatomic radicals
• The theory of atomicity of the elements
• Molecular epistemology
• A barometer of the science
• Writing a textbook
• Formulas, models, reality
• Excursus: a case in point
• Erlenmeyer and Kekulé
• Constant or variable atomicity?
• The heuristics of molecular representation
• Couper
• Loschmidt
• Butlerov
• Crum Brown
• Excursus: heurism in action
• The fate of the new graphic formulas
• Molecules as metaphors
• Natural types
• Absolute formulas
• Excursus: looking through the stereoscope
• Molecular democracy or autocracy?
• The revenge of Jupiter's children
• Aromatic apparitions
• First approaches to the problem
• Enter the hexagon
• Benzene through the phenakistoscope
• Excursus: ring around the rosie
• Metachemistry?
• Dimensional molecules
• Early stereospatial speculations
• The spiral staircase
• The pyramid
• Imagination in science: point/counterpoint
• Chemists, physicists, and the microworld
• Kopp's world
• The making of a chemist-historian
• In amongst the molecules
• The response
• The thirsty chemists
• Kekulé's dreams
• The festivities in Berlin
• Kekulé's speech
• The aftermath
• The eureka experience and the unconscious mind
• The scientific image-ination
• Mental images and science
• Mental images and history
• Transdictive images in physics and in chemistry.

Chemists in the nineteenth century were faced with a particular problem: how to depict the atoms and molecules beyond the direct reach of our bodily senses. In visualizing this microworld, these scientists were the first to move beyond high-level philosophical speculations regarding the unseen. In "Image and Reality", Alan J. Rocke focuses on the community of organic chemists in Germany to provide the basis for a fuller understanding of the nature of scientific creativity. Arguing that visual mental images assisted many of these scientists in thinking through old problems and new possibilities, Rocke uses a variety of sources, including private correspondence, diagrams and illustrations, scientific papers, and public statements to investigate their ability to not only imagine the invisibly tiny atoms and molecules upon which they operated daily, but to build detailed and empirically based pictures of them. These portrayals of 'chemical structures' gradually became an accepted part of science and are now regarded as one of the defining features of chemistry. In telling this fascinating story, Rocke also suggests that imagistic thinking is often at the heart of creative thinking in all fields.
(source: Nielsen Book Data)

• Basic properties of metal surfaces / A.L. Vázquez de Parga and R. Miranda
• Basic properties of silicon surfaces / M.J. Butcher and M.Y. Simmons
• Scanning tunneling microscopy and scanning force microscopy / S. Hernrhbacher and F. Giessibl
• Optical detection of single molecules at interfaces / B. Hecht
• Ab Initio modeling of molecular electronics / D. Roubtsov, N. Serqueev and H. Guo
• Perturbation methods in scanning tunneling microscopy / W.A. Hofer
• Properties of single molecules: manipulation, dissociation and synthesis with the scanning tunneling microscope / K.-F. Braun and S.-W. Hia
• Single-molecule vibrational spectroscopy and chemistry / J.I. Pascual and N. Lorente
• Superlattices of atoms, molecules and islands / H. Brune
• Mobility of complex organic species at metal surfaces / J.V. Barth
• Molecular monolayers on silicon surfaces / G.P. Lopinski and D.D.M. Wayner
• Functionalization of semiconductor surfaces by organic layers: Concerted cycloaddition versus stepwise free-radical reaction mechanisms / A. Bilić, J.R. Reimers and N.S. Hush
• Molecular electronics / R. Stadler
• Exploring the catalytic activity of a noble metal: the Ag catalyzed ethylene epoxidation reaction / M.-L. Bocquet and A. Michaelides.

Within nanoscience, an emerging discipline is the study of the physics and chemistry of single molecules. Molecules may be considered as the ultimate building blocks, and are therefore interesting for the development of molecular devices and for surface functionalization. Thus, it is interesting to study their properties when adsorbed on a suitable substrate such as a solid or crystal surface, and also for their potential applications in nano- or molecular-electronics and nanosensing. Investigations have been made possible by the advent of high resolution surface imaging and characterization techniques, commonly referred to as Scanning Probe Microscopes.This book focuses on the fascinating properties of the single molecules, and the difference between single molecules and ensembles of molecules is emphasized. As the first book intended for graduate courses in the field, after each chapter, students should be able to answer the question: "What physical or chemical properties do you learn from a single molecule in this particular context?" Contributed by experts across the disciplines, the book provides useful reference material for specialized practitioners in surface science, nanoscience and nanoelectronics.
(source: Nielsen Book Data)

• CONTENTS
• PROLOGUE
• INTRODUCTION
• A REMINISCENCE OR TWO ON PROFESSOR SIR DEREK BARTON, NOBEL LAUREATE
• INVENTING RADICAL CHAIN REACTIONS WITH DEREK BARTON AT THE INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES
• DEREK BARTON AS HIDDEN ADVISOR
• References
• DEREK H.R. BARTON â€? THE LIGHTER SIDE
• MY IMPRESSIONS OF DEREK
• SOME MEMORIES OF MY FORTY-FIVE YEAR ASSOCIATION WITH DEREK BARTON
• A MEMOIR: TWO YEARS WITH DEREK BARTON AT IMPERIAL COLLEGE (1971-1973)
• The Imperial College
• The Barton-McCombie Reaction
• The Barton Parking Lot

• And So To WorkInventing New Reactions
• Group Meetings
• Of Housing and Parties
• The Quinney/Dienone Synthesis
• The Baldwin Prize
• References
• SOME PERSONAL RECOLLECTIONS OF SIR DEREK BARTON FRS â€? A GENTLEMAN, A SCHOLAR, AND A VERY HUMAN BEING
• PROFESSOR D.H.R. BARTON, MY SPIRITUAL MENTOR
• SOME RECOLLECTIONS OF MY ASSOCIATION WITH SIR DEREK BARTON
• MY FRIEND â€? DEREK
• References
• SOME RECOLLECTIONS FROM A JAPANESE STUDENT AT IMPERIAL COLLEGE IN THE EARLY 1960S
• SOME CHEMISTRY WITH SIR DEREK
• References

• SIR DEREK BARTON'S 80TH BIRTHDAYALL ALONG ...
• SIR DEREK H.R. BARTON â€? AN EXCEPTIONAL SCIENTIST AND EXTRAORDINARY PERSON
• GRATEFUL MEMORIES BY A PREVIOUS POSTDOCTORAL FELLOW OF THE GIF ERA
• FIFTY YEARS WITH SIR DEREK BARTON
• REMEMBRANCE OF THE BARTON LABORATORY IN THE FIFTIES
• MON AMI DEREK
• SIR DEREK BARTON AND FREE RADICAL CHEMISTRY: A TESTIMONY
• References
• DEREK BARTON â€? THE HALF-A-CENTURY CHEMIST
• BASKING IN THE SHADOW OF A GREAT CHEMIST: HAPPY TIMES WITH SIR DEREK BARTON
• D. H.R.B. â€? SOME RECOLLECTIONS

The Bartonian Legacy is a collection of memoirs, reminiscences and biographical details regarding Sir Derek Barton (1918-1998) who was one of the most influential organic chemists of the 20th Century. The chapters are contributed by some of his many students, coworkers and scientific colleagues, all of whom testify to his fascinating character and true genius. It offers intimate glimpses at Sir Derek's scientific life, his sense of humor and his modus operandi as a teacher of research methods. The volume will serve as a valuable companion work to the more official biographies and obituaries, several of which have already been published.

• Cavitation and chemical reactivity (serving as Introduction, ca. 12-15 pp) including acoustic power measurements.- Efficient organic synthesis: what ultrasound makes it easier (ca. 15-20 pp) .- Sonication in neoteric solvents. A further look at synthetic plans (ca. 10-12 pp) .- Chemical modifications of renewable precursors: biomass valorization (ca. 10-12 pp) .- Gone with flow: miniaturization and safer chemistry (ca. 10-12 pp) .- Ultrasound as mechanical force (ca. 10-12 pp) .- Hybrid technologies in action: the US-MW reactor as prototype (ca. 10-12 pp) .- Scaling-up : Enabling the full potential of industrial applications of Ultrasound (ca. 10-12 pp)
• .
• (source: Nielsen Book Data)

This book provides informative, useful, and stimulating reading on the topic of organic sonochemistry - the core of ultrasound-based applications. Given the increasing interest in new and improved technologies, allied to their green and sustainable character (not always a valid premise), there is a great attraction for organic chemists to apply these protocols in synthesis and process chemistry. Unfortunately, as with other enabling technologies, many researchers new to the field have received a simple and dishonest message: just switch on! Therefore a significant portion of sonochemical syntheses lack reproducibility (surprisingly cavitation control and/or ultrasonic parameters are omitted) and the actual role of sonication remains uncertain. While this book does not provide a detailed description of fundamentals, the introductory remarks highlight the importance of cavitational effects and their experimental control. It presents a number of concepts of sonochemical reactivity and empirical rules with pertinent examples, often from classical and recent literature. It then focuses on scenarios of current interest where organic chemistry, and synthesis in particular, may benefit from sonication in terms of both chemical and mechanical activation. The "sustainable corner" of this field is largely exemplified through concepts like atom economy, renewable sources, wasteless syntheses, and benign solvents as reaction media. This book is useful for both researchers and graduate students, especially those familiar with the field of sonochemistry and applications of ultrasound in general. However, it is also of interest to a broader audience as it discusses the fundamentals, techniques, and experimental skills necessary for scientists wishing to initiate the use of ultrasound in their domain of expertise.
(source: Nielsen Book Data)

• Secondary metabolites from higher fungi / He-Ping Chen and Ji-Kai Liu
• Human deiminases: isoforms, substrate specificities, kinetics, and detection / Bushra Amin and Wolfgang Voelter
• Progress in the chemistry of naturally occurring coumarins / Satyajit D. Sarker and Lutfun Nahar.

• Anthraquinone and Anthraquinone Carboxylic AcidsCoupled Pre-anthraquinones; 2.3.4 Meroterpenoids Derived from the Acetate-Malonate Pathway; 2.3.5 Other Polyketides and Compounds of Fatty Acid Origin; 2.4 Pigments from the Mevalonate Pathway; 2.5 Pigments Containing Nitrogen; 2.5.1 Indoles; 2.5.2 Quinolines; 2.5.3 β-Carbolines; 2.5.4 Polyenes with Tetramic Acid or Amino Acid End Groups; 2.5.5 Other Pigments Containing Nitrogen; 3 Nitrogen-Containing Compounds of Higher Fungi; 3.1 Introduction; 3.2 Nitrogen Heterocycles; 3.2.1 Indoles; Simple Indoles; Isoindoles; 3.2.2 Pyridines and Pyrroles

• The search for anticancer agents from tropical plants.- Chemistry and biology of Mexican medicinal plants.
• (source: Nielsen Book Data)

The first review describes examples of very promising compounds discovered from plants acquired from Africa, Southeast Asia, the Americas, and the Caribbean region with potential anticancer activity. These include plant secondary metabolites of the diphyllin lignan, penta[b]benzofuran, triterpenoid, and tropane alkaloid types. The second review presents 40 more erythrinan alkaloids, which were either new or were missed out in the last major reviews, bringing to a total of 154 known erythrinan alkaloids known to date. The reported pharmacological activities of the new and known alkaloids showed a greater bias towards central nervous system and related activities. Other prominent activities reported were antifeedant or insecticidal, cytotoxicity/anti tumor/anti cancer/estrogenic, antiprotozoal, antiinflammatory, antioxidant, antifungal and antiviral activities.
(source: Nielsen Book Data)

• Preface
• Author
• Chapter 1 Clays and Clay Minerals: Structures, Compositions, and Properties
• Chapter 2 Surface Acidity and Catalytic Activity
• Chapter 3 Surface Activation and Modification
• Chapter 4 Organic Catalysis by Clay-Supported Reagents
• Chapter 5 Clay Mineral Catalysis of Name Reactions
• Chapter 6 Clay Mineral Catalysis of Isomerization, Dimerization, Oligomerization, and Polymerization Reactions
• Chapter 7 Clay Mineral Catalysis of Redox, Asymmetric, and Enantioselective Reactions
• Chapter 8 Clay Mineral Catalysis of Natural Processes and Prebiotic Organic Reactions
• Index.
• (source: Nielsen Book Data)

The book provides insight into the working of clays and clay minerals in speeding up a variety of organic reactions. Clay minerals are known to have a large propensity for taking up organic molecules and can catalyse numerous organic reactions due to fine particle size, extensive surface area, layer structure, and peculiar charge characteristics. They can be used as heterogeneous catalysts and catalyst carriers of organic reactions because they are non-corrosive, easy to separate from the reaction mixture, and reusable. Clays and clay minerals have an advantage over other solid acids as they are abundant, inexpensive, and non-polluting.
(source: Nielsen Book Data)

• Cover; Preface to the Third Edition; Preface to the First Edition; Contents; Chapter-1. Fundamental Principles and Special Topics; 1.1 Structure and Bonding in Organic Compounds; 1.2 Electronegativity
• Dipole Moment; 1.3 Inductive and Field Effects; 1.4 Hydrogen Bond; 1.5 Other Weaker Bonds; 1.6 Bond Dissociation Energy; 1.7 The Hammet Equation
• Linear Free Energy Relationship; 1.8 Taft Equation; 1.9 Steric Effects, Strains and Bredt Rule; Problems; Answers to the Problems; Chapter -2. Delocalized Chemical Bonding; 2.1 1,3-Butadiene a Typical Conjugated System; 2.2 Resonance.

• 2.3 Aromaticity2.4 The Terms Aromatic, Antiaromatic and Nonaromatic; 2.5 Annulenes; 2.6 The Frost Circle
• Molecular Orbital Description of Aromaticity and Antiaromaticity; 2.7 Aromatic and Antiaromatic Ions; 2.8 Other Non
• Benzenoid Aromatic Compounds; 2.9 Heterocyclic Aromatic Compounds; 2.10 Metallocenes and Related Compounds; 2.11 Fused Benzenoids and Fullerenes; 2.12 Homoromatic Compounds; 2.13 Hyperconjegation; 2.14 Hexahelicene; 2.15 Tautomerism; Problems; Answers to the Problems; Chapter -3. Organic Acids and Bases; 3.1 The Bronsted
• Lowry concepts of Acids and Bases.

• 3.2 The Lewis Definition of Acids and Bases3.3 The Relation Between Structure and Acidity; 3.4 Bases; 3.5 Relation Between Structure and Basicity; 3.6 Synthetic Applications of Lithium Diisopropylamide (LDA); 3.7 Acid-Base Reactions; 3.8 The Effects of the Solvent on Acid and Base Strength; 3.9 Leveling Effects; 3.10 Hard And Soft Acids and Bases; Problems; Answer to the Problems; Chapter
• 4. Organic Reactions and the Determination of their Mechanisms; 4.1 Mechanistic Classification; 4.2 Nucleophiles and Electrophiles; 4.3 Electron Movement; 4.4 Equilibria and free Energy.

• 4.5 Free Energy Change in Relation to Bond Strengths and Degree of Order in a System4.6 Reaction Rates; 4.7 The Transition State
• Activation Energy; 4.8 Transition State Theory
• Measurement of Activation Energy; 4.9 Reaction Profile Diagrams; 4.10 The Rate Determining Step; 4.11 Thermodynamic and Kinetic Control; 4.12 Applications of Kinetic Principles; 4.13 The Curtin
• Hammett Principle
• Importance of Transition State; 4.14 Microscopic Reversibility; 4.15 Methods of Determining Mechanisms; 4.16 Reactive Intermediates; Problems; Answers to the Problems.

• Chapter-5. Aliphatic Nucleophilic Substitution and its Synthetic Applications5.1 Introduction; 5.2 Synchronous Substitution
• SN2 Process; 5.3 Substitution By Ionization _ SN1 Mechanism; 5.4 SN1 Versus SN2 Reactions; 5.5 Other Aliphatic Substitutions Pathways; 5.6 The Role of Ion Pairs; 5.7 Neighbouring Group Participation and Nonclassical Carbocations; 5.8 Nucleophilic Substitution at Silicon; Problems; Answers to the Problems; Chapter
• 6. Common Organic Reactions and their Mechanisms; 6.1 Base Catalysed Reactions (Formation of Carbon
• Carbon Bonds).

• 6.2 Stork Enamine Reactions (Formation of Carbon
• Carbon Bonds)
• Reaction of an Enamine with Reactive Electrophiles.

• 1 An Overview of the Physical and Photophysical Properties of [Ru(bpy)3]2+ 1 DanielaM. Arias-Rotondo and James K. McCusker 1.1 Introduction 1 1.2 [Ru(bpy)3]2+: Optical and Electrochemical Properties 4 1.2.1 Optical Properties 4 1.2.2 Electrochemical Properties 6 1.3 Excited State Kinetics 8 1.3.1 Steady-State Emission 8 1.3.2 Time-Resolved Emission 10 1.4 Excited-State Reactivity of [Ru(bpy)3]2+ 11 1.5 Energy Transfer: Foerster and Dexter Mechanisms 12 1.6 Electron Transfer 14 1.7 Probing the Mechanism, Stage I: Stern-Volmer Quenching Studies 14 1.8 Probing the Mechanism, Stage II: Electron Versus Energy Transfer 16 1.9 Designing Photocatalysts: [Ru(bpy)3]2+ as a Starting Point 20 1.10 Conclusion 22 References 23
• 2 Visible-Light-Mediated Free Radical Synthesis 25 Louis Fensterbank, Jean-Philippe Goddard, and Cyril Ollivier 2.1 Introduction 25 2.2 Basics of the Photocatalytic Cycle 26 2.3 Generation of Radicals 27 2.3.1 Formation of C-Centered Radicals 27 2.3.1.1 Dehalogenation (I, Br, Cl) 27 2.3.1.2 Other C-Heteroatom Cleavage 29 2.3.1.3 C-C Bond Cleavage 29 2.3.2 Formation of N-Centered Radicals 30 2.4 C-X Bond Formation 30 2.4.1 C-O Bond 30 2.4.2 C-N Bond 32 2.4.3 C-S and C-Se Bonds 33 2.4.4 C-Br Bond 34 2.4.5 C-F Bond 34 2.4.6 C-B Bond 35 2.5 C-C Bond Formation 35 2.5.1 Formation and Reactivity of Aryl Radicals 35 2.5.2 Formation and Reactivity of Trifluoromethyl and Related Radicals 40 2.5.2.1 Photocatalyzed Reduction of Perfluorohalogen Derivatives 40 2.5.2.2 Photocatalyzed Reduction of Perfluoroalkyl-Substituted Onium Salts 42 2.5.2.3 Photocatalyzed Formation of Perfluoroalkyl Radicals from Sulfonyl and Sulfinyl Derivatives 43 2.5.3 Formation and Reactivity of Alkyl and Related Radicals 45 2.5.3.1 C-C Bond FormationThrough Photocatalyzed Reduction of Halogen Derivatives and Analogs 45 2.5.3.2 C-C Bond FormationThrough Photocatalyzed Oxidation of Electron-Rich Functional Group 47 2.5.3.3 C-C Bond FormationThrough Photocatalyzed Oxidation of Amino Group 48 2.6 Radical Cascade Applications 49 2.6.1 Intramolecular Polycyclization Processes 49 2.6.2 Sequential Inter- and Intramolecular Processes 51 2.6.3 Sequential Radical and Polar Processes 56 References 59
• 3 AtomTransfer Radical Addition using Photoredox Catalysis 73 Theresa M.Williams and Corey R. J. Stephenson 3.1 Introduction 73 3.2 Transition Metal-Catalyzed ATRA 77 3.2.1 Ruthenium- and Iridium-Based ATRA 77 3.2.1.1 Mechanistic Investigations 77 3.2.1.2 Ruthenium- and Iridium-Based ATRA 80 3.2.2 Copper-Mediated ATRA 81 3.2.2.1 Trifluoromethylation 82 3.3 Other Photocatalysts for ATRA Transformations 84 3.3.1 p-Anisaldehyde 84 3.4 Semiconductor 86 3.5 Atom Transfer Radical Cyclization (ATRC) 87 3.6 Atom Transfer Radical Polymerization (ATRP) 89 3.7 Conclusion 90 References 90
• 4 Visible Light Mediated -----Amino C-H Functionalization Reactions 93 You-Quan Zou andWen-Jing Xiao 4.1 Introduction 93 4.2 Visible Light Mediated -Amino C-H Functionalization Via Iminium Ions 95 4.2.1 Aza-Henry Reaction 95 4.2.2 Mannich Reaction 100 4.2.3 Strecker Reaction 104 4.2.4 Friedel-Crafts Reaction 105 4.2.5 Alkynylation Reaction 108 4.2.6 Phosphonation Reaction 109 4.2.7 Addition of 1,3-Dicarbonyls 109 4.2.8 Formation of C-N and C-O Bonds 110 4.2.9 Miscellaneous 112 4.3 Visible Light Mediated -Amino C-H Functionalization Via -Amino Radicals 116 4.3.1 Addition to Electron-Deficient Aromatics 116 4.3.2 Addition to Electron-Deficient Alkenes 116 4.3.3 Miscellaneous 120 4.4 Conclusions and Perspectives 121 References 122
• 5 Visible Light Mediated Cycloaddition Reactions 129 Scott Morris, Theresa Nguyen, and Nan Zheng 5.1 Introduction 129 5.2 [2+2] Cycloadditions: Formation of Four-Membered Rings 130 5.2.1 Introduction to [2+2] Cycloadditions 130 5.2.2 Utilization of the Reductive Quenching Cycle 130 5.2.3 Utilization of the Oxidative Quenching Cycle 135 5.2.4 Utilization of Energy Transfer 139 5.2.5 [2+2] Conclusion 142 5.3 [3+2] Cycloadditions: Formation of Five-Membered Rings 143 5.3.1 Introduction to [3+2] Cycloadditions 143 5.3.2 [3+2] Cycloaddition of Cyclopropylamines 143 5.3.3 1,3-Dipolar Cycloaddition of Azomethine Ylides 145 5.3.4 [3+2] Cycloaddition of Aryl Cyclopropyl Ketones 146 5.3.5 [3+2] Cycloaddition via ATRA/ATRC 146 5.3.6 [3+2] Conclusion 148 5.4 [4+2] Cycloadditions: Formation of Six-Membered Rings 149 5.4.1 Introduction to [4+2] Cycloadditions 149 5.4.2 [4+2] Cycloadditions Using Radical Anions 149 5.4.3 [4+2] Cycloadditions Using Radical Cations 151 5.4.4 [4+2] Conclusion 154 5.5 Conclusion 155 References 156
• 6 Metal-Free Photo(redox) Catalysis 159 Kirsten Zeitler 6.1 Introduction 159 6.1.1 Background 162 6.1.2 Classes of Organic Photocatalysts 162 6.2 Applications of Organic Photocatalysts 166 6.2.1 Energy Transfer Reactions 166 6.2.2 Reductive Quenching of the Catalyst 171 6.2.2.1 Cyanoarenes 171 6.2.2.2 Quinones 172 6.2.2.3 Cationic Dyes: Pyrylium, Quinolinium, and Acridinium Scaffolds 173 6.2.2.4 Xanthene Dyes and Further Aromatic Scaffolds 188 6.2.3 Oxidative Quenching of the Catalyst 203 6.2.4 New Developments 214 6.2.4.1 Upconversion 215 6.2.4.2 Consecutive Photoelectron Transfer 215 6.2.4.3 Multicatalysis 216 6.3 Conclusion and Outlook 224 References 224
• 7 Visible Light and Copper Complexes: A Promising Match in Photoredox Catalysis 233 Suva Paria and Oliver Reiser 7.1 Introduction 233 7.2 Photophysical Properties of Copper Catalysts 234 7.3 Application of Copper Based Photocatalysts in Organic Synthesis 237 7.4 Outlook 247 Acknowledgment 248 References 248
• 8 Arene Functionalization by Visible Light Photoredox Catalysis 253 Durga Hari Prasad, Thea Hering, and Burkhard Koenig 8.1 Introduction 253 8.1.1 Aryl Diazonium Salts 253 8.1.2 Diaryl Iodonium Salts 268 8.1.3 Triaryl Sulfonium Salts 272 8.1.4 Aryl Sulfonyl Chlorides 273 8.2 Applications of Aryl Diazonium Salts 274 8.3 Photoinduced Ullmann C-N Coupling 276 8.4 Conclusion 278 References 278
• 9 Visible-Light Photocatalysis in the Synthesis of Natural Products 283 Gregory L. Lackner, KyleW. Quasdorf, and Larry E. Overman References 295
• 10 Dual Photoredox Catalysis: TheMerger of Photoredox Catalysis with Other Catalytic Activation Modes 299 Christopher K. Prier and DavidW. C. MacMillan 10.1 Introduction 299 10.2 Merger of Photoredox Catalysis with Organocatalysis 300 10.3 Merger of Photoredox Catalysis with Acid Catalysis 314 10.3.1 Photoredox Catalysis and Bronsted Acid Catalysis 314 10.3.2 Photoredox Catalysis and Lewis Acid Catalysis 318 10.4 Merger of Photoredox Catalysis with Transition Metal Catalysis 320 10.5 Conclusions 328 References 328
• 11 Enantioselective Photocatalysis 335 Susannah C. Coote and Thorsten Bach 11.1 Introduction 335 11.2 The Twentieth Century: PioneeringWork 336 11.3 The Twenty-First Century: Contemporary Developments 341 11.3.1 Large-Molecule Chiral Hosts 341 11.3.2 Small-Molecule Chiral Photosensitizers 343 11.3.3 Lewis Acid-Mediated Photoreactions 353 11.4 Conclusions and Outlook 357 References 358
• 12 Photomediated Controlled Polymerizations 363 Nicolas J. Treat, Brett P. Fors, and Craig J. Hawker 12.1 Catalyst Activation by Light 365 12.1.1 Cu-Catalyzed Photoregulated Atom Transfer Radical Polymerizations (photoATRP) 365 12.1.2 Photomediated ATRP with Non-Copper-Based Catalyst Systems 368 12.1.3 Iodine-Mediated Photopolymerizations 371 12.1.4 Metal-Free Photomediated Ring-Opening Metathesis Polymerization 375 12.1.5 Photoregulated Reversible-Addition Fragmentation Chain Transfer Polymerizations (photoRAFT) 376 12.2 Chain-End Activation by Light 383 12.3 Conclusions 384 References 385
• 13 Accelerating Visible-Light Photoredox Catalysis in Continuous-Flow Reactors 389 Natan J.W. Straathof and Timothy Noel 13.1 Introduction 389 13.2 Homogeneous Photocatalysis in Single-Phase Flow 392 13.3 Gas-liquid Photocatalysis in Flow 401 13.4 Heterogeneous Photocatalysis in Flow 408 13.5 Conclusions 410 Conflict of Interest 410 References 410
• 14 The Application of Visible-Light-Mediated Reactions to the Synthesis of Pharmaceutical Compounds 415 James. J. Douglas 14.1 Introduction 415 14.2 Asymmetric Benzylation 415 14.3 Amide Bond Formation 416 14.4 C-H Azidation 417 14.5 Visible-Light-Mediated Benzothiophene Synthesis 418 14.6 -Amino Radical Functionalization 419 14.7 Visible-Light-Mediated Radical Smiles Rearrangement 422 14.8 Photoredox and Nickel Dual Catalysis 423 14.9 The Scale-Up of Visible-Light-Mediated Reactions Via Continuous Processing 426 References 428 Index 431.
• (source: Nielsen Book Data)

• FUNDAMENTAL ASPECTS OF PHOTOCATALYSIS: ENERGY TRANSFER AND ELECTRON TRANSFER MECHANISMS (PHOTOPHYSICAL AND ELECTROCHEMICAL PROPERTIES OF PHOTOREDOX COMPLEXES)
• APPLICATIONS IN ORGANIC SYNTHESIS: AN HISTORICAL PERSPECTIVE
• ENANTIOSELECTIVE PHOTOCATALYSIS
• PHOTOREDOX ORGANOCATALYSIS
• CYCLOADDITION REACTIONS
• C-H FUNCTIONALIZATION
• METAL-FREE PHOTOREDOX CATALYSIS
• PHOTOCATALYTIC POLYMERIZATION
• BIMETALLIC/CO-CATALYSIS
• FREE RADICAL CHEMISTRY
• ARENE FUNCTIONALIZATIONS
• TECHNOLOGY APPLICATIONS IN PHOTOCHEMISTRY
• SEMICONDUCTOR PHOTOCATALYSIS
• APPLICATIONS IN COMPLEX MOLECULE SYNTHESIS.
• (source: Nielsen Book Data)

Filling the need for a ready reference that reflects the vast developments in this field, this book presents everything from fundamentals, applications, various reaction types, and technical applications. Edited by rising stars in the scientific community, the text focuses solely on visible light photocatalysis in the context of organic chemistry. This primarily entails photoinduced electron transfer and energy transfer chemistry sensitized by polypyridyl complexes, yet also includes the use of organic dyes and heterogeneous catalysts. A valuable resource to the synthetic organic community, polymer and medicinal chemists, as well as industry professionals.
(source: Nielsen Book Data)

• The Organic Chemistry Literature. Abstracting and Other Current Awareness Services. Principal Electronic Dictionaries. Useful Reference Works and Review Series. Patents, Including Patent Awareness Services. Cheminformatics Companies. Primary Journals. Endnotes. Nomenclature Fundamentals . IUPAC Nomenclature. CAS Nomenclature. Types of Name. Constructing a Systematic Name. Nomenclature of Ring Systems. Ring Systems (General). Bridged Ring Systems. Spiro Compounds. Heterocyclic Ring Systems. Ring Assemblies. Ring Fusion Names. Nomenclature of Individual Classes of Compound. Carbohydrates. Alditols and Cyclitols. Amino Acids and Peptides. Natural Products (General). Steroids. Lipids. Carotenoids. Lignans. Nucleotides and Nucleosides. Tetrapyrroles. Organoboron Compounds. Organophosphorus (and Organoarsenic) Compounds. Azo and Azoxy Compounds. Labelled Compounds. Tautomeric Compounds. Acronyms and Miscellaneous Terms Used in Describing Organic Molecules. Abbreviations and Acronyms for Reagents and Protecting Groups in Organic Chemistry. Glossary of Miscellaneous Terms and Techniques Used in Nomenclature, Including Colloquial Terms. Stereochemistry. The Sequence Rule: R and S. Graphical and Textual Representations of Stereochemistry. Chiral Molecules with No Centres of Chirality. E and Z. The D, L-System. Descriptors and Terms Used in Stereochemistry. Graphical Representation of Organic Compounds. Zigzag Natta Projection. Stereochemistry. CAS Numbers, InChI, and Other Identifiers. CAS Registry Numbers. InChI. Simplified Molecular Input Line Entry System (SMILES). Molecular Formulae. The Hill System. Chemical Abstracts Conventions.Checking Molecular Formulae. Chemical Hazard Information for the Laboratory. Hazard and Risk Assessment. Physical and Reactive Chemical Hazards. Health Hazards. Handling and Storage of Chemicals. Hazardous Reaction Mixtures. Disposal of Chemicals. Solvents. Peroxide- Forming Chemicals. Further Literature Sources. Spectroscopy. Infrared Spectroscopy. Ultraviolet Spectroscopy. Nuclear Magnetic Resonance Spectroscopy. Mass Spectrometry. Introduction. Ionisation Techniques and Mass Spectrometer Systems. Interpreting Mass Spectra and Molecular Mass. Sample Introduction and Solvent Systems for Electrospray Mass Spectrometry. Common Adducts and Contaminants in Mass Spectra. MALDI Matrices. Fragment Ions and Neutral Losses. Natural Abundance and Isotopic Masses of Selected Isotopes and Nuclear Particles. Glossary of Abbreviations and Terms Commonly Used in Mass Spectrometry. Crystallography. Introduction. Definitions.Crystallographic Point Groups. Space Groups. Reciprocal Lattice. Examples of Organic Crystals. CIF Data Format. Bragg's Law and the X-Ray Spectrum. Crystal Specimen Preparation for X-Ray Analysis. Chromatographic Chiral Separation. Types of Molecular Interactions. Diastereomeric Compounds and Complexes. Chiral Mobile Phases. Chiral Stationary Phases. Laboratory Data and SI Units. Solvents. Buffer Solutions. Acid and Base Dissociation Constants. Resolving Agents. Freezing Mixtures. Materials Used for Heating Baths. Drying Agents. Pressure-Temperature Nomograph. SI Units. Languages. A German-English Dictionary. Russian and Greek Alphabets. SI Units. Index.
• (source: Nielsen Book Data)

• The Organic Chemistry Literature Abstracting and Other Current Awareness Services Principal Electronic Dictionaries and Chemical Compound Databases Reference Works and Review Series Patent Literature on the Web
• Primary Journals Electronic Sources for Chemistry Journals Leading Publishers of Chemistry Journals and Chemical Information
• Nomenclature Fundamentals Introduction IUPAC Nomenclature General Principles of Nomenclature Chemical Abstracts (CAS) Nomenclature Types of Name Constructing a Systematic Name Azo and Azoxy Compounds Tautomeric Compounds Nomenclature Algorithms
• Nomenclature of Ring Systems Ring Systems (General) Bridged Ring Systems Heterocyclic Ring Systems Spiro Compounds Ring Assemblies Ring Fusion Names
• Stereochemistry The Sequence Rule: R and S Graphical and Textual Representations of Stereochemistry Chiral Molecules with No Centres of Chirality E and Z The d, l-System Descriptors and Terms Used in Stereochemistry
• Graphical Representation of Organic Compounds Zigzag Natta Projection Stereochemistry
• Structure and Nomenclature of Some Individual Classes of Compounds Carbohydrates Alditols and Cyclitols Amino Acids and Peptides Nucleotides and Nucleosides Steroids Lipids Organoboron Compounds Organophosphorus (and Organoarsenic) Compounds Labelled Compounds
• Infrared and Ultraviolet Spectroscopy Infrared Spectroscopy Ultraviolet Spectroscopy
• Nuclear Magnetic Resonance Spectroscopy Common Nuclei Used in NMR Chemical Shift Data Coupling Constants Modern NMR Techniques for Structural Elucidation of Small Molecules Determination of Structure by a Combination of IR and NMR
• Mass Spectrometry Introduction Ionisation Techniques and Mass Spectrometer Systems Interpreting Mass Spectra and Molecular Mass Sample Introduction and Solvent Systems for Electrospray Mass Spectrometry Common Adducts and Contaminants in Mass Spectra MALDI Matrices Fragment Ions and Neutral Losses Natural Abundance and Isotopic Masses of Selected Isotopes and Nuclear Particles Glossary of Abbreviations and Terms Commonly Used in Mass Spectrometry
• Crystallography Introduction Definitions Crystallographic Point Groups Space Groups Reciprocal Lattice Examples of Organic Crystals CIF Data Format Bragg's Law and the X-ray Spectrum Crystal Specimen Preparation for X-ray Analysis
• Chemical Hazard Information for the Laboratory Hazard and Risk Assessment Physical and Reactive Chemical Hazards Health Hazards of Chemicals Handling and Storage of Chemicals Hazardous Reaction Mixtures Disposal of Chemicals Solvents Peroxide-Forming Chemicals Reactive Inorganic Reagents Including Strong Acids and Bases COSHH Assessments for the Organic Chemistry Laboratory Further Literature Sources of Hazard Information
• Abbreviations and Acronyms for Reagents and Protecting Groups in Organic Chemistry
• Glossary of Miscellaneous Terms and Techniques Used in Nomenclature, Including Colloquial Terms
• Representation of Organic Compounds: Molecular Formulae, CAS Registry Numbers and Linear Notations Molecular Formulae CAS Registry Numbers InChI (TM) Simplified Molecular-Input Line-Entry System
• Laboratory Data and SI Units Solvents Buffer Solutions Acid and Base Dissociation Constants Resolving Agents Freezing Mixtures Materials Used for Heating Baths Drying Agents Properties of Common Gases Pressure-Temperature Nomograph SI Units Further Reading on SI Units Websites
• Languages German-English Dictionary Russian and Greek Alphabets
• Index.
• (source: Nielsen Book Data)

Launched in 1995 as a companion to the Dictionary of Organic Compounds, the Organic Chemist's Desk Reference has been essential reading for laboratory chemists who need a succinct guide to the 'nuts and bolts' of organic chemistry - the literature, nomenclature, stereochemistry, spectroscopy, hazard information, and laboratory data. This third edition reflects changes in the dissemination of chemical information, revisions to chemical nomenclature, and the adoption of new techniques in NMR spectroscopy, which have taken place since publication of the last edition in 2011. Organic chemistry embraces many other disciplines - from material sciences to molecular biology - whose practitioners will benefit from the comprehensive but concise information brought together in this book. Extensively revised and updated, this new edition contains the very latest data that chemists need access to for experimentation and research.
(source: Nielsen Book Data)

This book provides state-of-the-art information on how studies in applied theoretical organic chemistry are conducted. It highlights the many approaches and tools available to those interested in using computational chemistry to predict and rationalize structures and reactivity of organic molecules. Chapters not only describe theoretical techniques in detail, but also describe recent applications and offer practical advice. Authored by many of the world leaders in the field of applied theoretical chemistry, this book is perfect for both practitioners of computational chemistry and synthetic and mechanistic organic chemists curious about applying computational techniques to their research.
(source: Nielsen Book Data)

• Preface xi
• 1 Introduction 1
• 2 Quantum Mechanics 11
• 2.1 Fundamentals 11
• 2.1.1 Postulates of Quantum Mechanics 11
• 2.1.2 Lagrangian and Hamiltonian Formalisms 11
• 2.1.3 Wave Functions and Operators 18
• 2.2 Time Evolution ofWave Functions 22
• 2.3 Time Evolution of Expectation Values 25
• 2.4 Variational Principle 27
• Further Reading 29
• 3 Particles and Fields 31
• 3.1 Microscopic Maxwell s Equations 32
• 3.1.1 General Considerations 32
• 3.1.2 The Stationary Case 34
• 3.1.3 The General Case 38
• 3.1.4 Electromagnetic Potentials and Gauge Freedom 39
• 3.1.5 ElectromagneticWaves and Polarization 41
• 3.1.6 Electrodynamics: Relativistic and Nonrelativistic Formulations 45
• 3.2 Particles in Electromagnetic Fields 48
• 3.2.1 The Classical Mechanical Hamiltonian 48
• 3.2.2 The Quantum-Mechanical Hamiltonian 52
• 3.3 Electric and Magnetic Multipoles 57
• 3.3.1 Multipolar Gauge 57
• 3.3.2 Multipole Expansions 59
• 3.3.3 The Electric Dipole Approximation and Beyond 63
• 3.3.4 Origin Dependence of Electric and MagneticMultipoles 64
• 3.3.5 Electric Multipoles 65
• 3.3.5.1 General Versus Traceless Forms 65
• 3.3.5.2 WhatWe Can Learn from Symmetry 68
• 3.3.6 MagneticMultipoles 69
• 3.3.7 Electric Dipole Radiation 70
• 3.4 Macroscopic Maxwell s Equations 72
• 3.4.1 Spatial Averaging 72
• 3.4.2 Polarization and Magnetization 73
• 3.4.3 Maxwell s Equations in Matter 77
• 3.4.4 Constitutive Relations 79
• 3.5 Linear Media 81
• 3.5.1 Boundary Conditions 82
• 3.5.2 Polarization in LinearMedia 86
• 3.5.3 ElectromagneticWaves in a Linear Medium 92
• 3.5.4 Frequency Dependence of the Permittivity 96
• 3.5.4.1 Kramers Kronig Relations 97
• 3.5.4.2 Relaxation in the Debye Model 98
• 3.5.4.3 Resonances in the LorentzModel 101
• 3.5.4.4 Refraction and Absorption 104
• 3.5.5 Rotational Averages 107
• 3.5.6 A Note About Dimensions, Units, and Magnitudes 110
• Further Reading 111
• 4 Symmetry 113
• 4.1 Fundamentals 113
• 4.1.1 Symmetry Operations and Groups 113
• 4.1.2 Group Representation 117
• 4.2 Time Symmetries 120
• 4.3 Spatial Symmetries 125
• 4.3.1 Spatial Inversion 125
• 4.3.2 Rotations 127
• Further Reading 134
• 5 Exact-State Response Theory 135
• 5.1 Responses in Two-Level System 135
• 5.2 Molecular Electric Properties 145
• 5.3 Reference-State Parameterizations 151
• 5.4 Equations of Motion 156
• 5.4.1 Time Evolution of Projection Amplitudes 157
• 5.4.2 Time Evolution of Rotation Amplitudes 159
• 5.5 Response Functions 163
• 5.5.1 First-Order Properties 166
• 5.5.2 Second-Order Properties 166
• 5.5.3 Third-Order Properties 169
• 5.5.4 Fourth-Order Properties 174
• 5.5.5 Higher-Order Properties 179
• 5.6 Dispersion 179
• 5.7 Oscillator Strength and Sum Rules 183
• 5.8 Absorption 185
• 5.9 Residue Analysis 190
• 5.10 Relaxation 194
• 5.10.1 Density Operator 195
• 5.10.2 Liouville Equation 196
• 5.10.3 Density Matrix from PerturbationTheory 200
• 5.10.4 Linear Response Functions from the Density Matrix 201
• 5.10.5 Nonlinear Response Functions from the Density Matrix 204
• 5.10.6 Relaxation inWave FunctionTheory 204
• 5.10.7 Absorption Cross Section 207
• 5.10.8 Einstein Coefficients 210
• Further Reading 211
• 6 Electronic and Nuclear Contributions to Molecular Properties 213
• 6.1 Born Oppenheimer Approximation 213
• 6.2 Separation of Response Functions 216
• 6.3 Molecular Vibrations and Normal Coordinates 221
• 6.4 PerturbationTheory for VibrationalWave Functions 225
• 6.5 Zero-Point Vibrational Contributions to Properties 227
• 6.5.1 First-Order Anharmonic Contributions 227
• 6.5.2 Importance of Zero-Point Vibrational Corrections 231
• 6.5.3 Temperature Effects 234
• 6.6 Pure Vibrational Contributions to Properties 235
• 6.6.1 PerturbationTheory Approach 235
• 6.6.2 Pure Vibrational Effects from an Analysis of the Electric-Field Dependence of the Molecular Geometry 238
• 6.7 Adiabatic Vibronic Theory for Electronic Excitation Processes 244
• 6.7.1 Franck Condon Integrals 248
• 6.7.2 Vibronic Effects in a Diatomic System 250
• 6.7.3 Linear Coupling Model 252
• 6.7.4 Herzberg Teller Corrections and Vibronically Induced Transitions 252
• Further Reading 253
• 7 Approximate Electronic State Response Theory 255
• 7.1 Reference State Parameterizations 255
• 7.1.1 Single Determinant 255
• 7.1.2 Configuration Interaction 263
• 7.1.3 Multiconfiguration Self-consistent Field 266
• 7.1.4 Coupled Cluster 268
• 7.2 Equations of Motion 271
• 7.2.1 EhrenfestTheorem 271
• 7.2.2 Quasi-Energy Derivatives 275
• 7.3 Response Functions 276
• 7.3.1 Single Determinant Approaches 276
• 7.3.2 Configuration Interaction 281
• 7.3.3 Multiconfiguration Self-Consistent Field 281
• 7.3.4 Matrix Structure in the SCF, CI, and MCSCF Approximations 281
• 7.3.5 Coupled Cluster 285
• 7.4 Residue Analysis 288
• 7.5 Relaxation 291
• 8 Response Functions and Spectroscopies 295
• 8.1 Nuclear Interactions 296
• 8.1.1 Nuclear Charge Distribution 296
• 8.1.2 Hyperfine Structure 301
• 8.1.2.1 Nuclear Magnetic Dipole Moment 301
• 8.1.2.2 Nuclear Electric Quadrupole Moment 305
• 8.2 Zeeman Interaction and Electron Paramagnetic Resonance 310
• 8.3 Polarizabilities 317
• 8.3.1 Linear Polarizability 317
• 8.3.1.1 Weak Intermolecular Forces 321
• 8.3.2 Nonlinear Polarizabilities 325
• 8.4 Magnetizability 326
• 8.4.1 The Origin Dependence of the Magnetizability 328
• 8.4.2 Magnetizabilities from Magnetically Induced Currents 331
• 8.4.3 Isotropic Magnetizabilities and Pascal s Rule 332
• 8.5 Electronic Absorption and Emission Spectroscopies 335
• 8.5.1 Visible and Ultraviolet Absorption 338
• 8.5.2 Fluorescence Spectroscopy 343
• 8.5.3 Phosphorescence 344
• 8.5.4 Multiphoton Absorption 347
• 8.5.4.1 Multiphoton Absorption Cross Sections 348
• 8.5.4.2 Few-State Models for Two-Photon Absorption Cross Section 350
• 8.5.4.3 General Multiphoton Absorption Processes 351
• 8.5.5 X-ray Absorption 354
• 8.5.5.1 Core-Excited States 355
• 8.5.5.2 Field Polarization 358
• 8.5.5.3 Static Exchange Approximation 360
• 8.5.5.4 Complex or Damped Response Theory 362
• 8.6 Birefringences and Dichroisms 364
• 8.6.1 Natural Optical Activity 366
• 8.6.2 Electronic Circular Dichroism 372
• 8.6.3 Nonlinear Birefringences 375
• 8.6.3.1 Magnetic Circular Dichroism 376
• 8.6.3.2 Electric Field Gradient-Induced Birefringence 379
• 8.7 Vibrational Spectroscopies 381
• 8.7.1 Infrared Absorption 381
• 8.7.1.1 Double-Harmonic Approximation 381
• 8.7.1.2 Anharmonic Corrections 383
• 8.7.2 Vibrational Circular Dichroism 384
• 8.7.3 Raman Scattering 388
• 8.7.3.1 Raman Scattering from a Classical Point of View 388
• 8.7.3.2 Raman Scattering from a Quantum Mechanical Point of View 392
• 8.7.4 Vibrational Raman Optical Activity 402
• 8.8 Nuclear Magnetic Resonance 407
• 8.8.1 The NMR Experiment 407
• 8.8.2 NMR Parameters 412
• Further Reading 417
• A Abbreviations 419
• B Units 421
• C Second Quantization 423
• C.1 Creation and Annihilation Operators 423
• C.2 Fock Space 425
• C.3 The Number Operator 426
• C.4 The Electronic Hamiltonian on Second-Quantized Form 427
• C.5 Spin in Second Quantization 429
• D Fourier Transforms 431
• E Operator Algebra 435
• F Spin Matrix Algebra 439
• G Angular Momentum Algebra 441
• H Variational Perturbation Theory 445
• I Two-Level Atom 451
• I.1 Rabi Oscillations 452
• I.2 Time-Dependent PerturbationTheory 454
• I.3 The Quasi-energy Approach 455
• Index 457.
• (source: Nielsen Book Data)

A comprehensive yet accessible exploration of quantum chemical methods for the determination of molecular properties of spectroscopic relevance Molecular properties can be probed both through experiment and simulation. This book bridges these two worlds, connecting the experimentalist's macroscopic view of responses of the electromagnetic field to the theoretician s microscopic description of the molecular responses. Comprehensive in scope, it also offers conceptual illustrations of molecular response theory by means of time-dependent simulations of simple systems. This important resource in physical chemistry offers: A journey in electrodynamics from the molecular microscopic perspective to the conventional macroscopic viewpoint The construction of Hamiltonians that are appropriate for the quantum mechanical description of molecular properties Time- and frequency-domain perspectives of light matter interactions and molecular responses of both electrons and nuclei An introduction to approximate state response theory that serves as an everyday tool for computational chemists A unified presentation of prominent molecular properties Principles and Practices of Molecular Properties: Theory, Modeling and Simulations is written by noted experts in the field. It is a guide for graduate students, postdoctoral researchers and professionals in academia and industry alike, providing a set of keys to the research literature.
(source: Nielsen Book Data)

• 1 An Overview of the Physical and Photophysical Properties of [Ru(bpy)3]2+ 1 DanielaM. Arias-Rotondo and James K. McCusker 1.1 Introduction 1 1.2 [Ru(bpy)3]2+: Optical and Electrochemical Properties 4 1.2.1 Optical Properties 4 1.2.2 Electrochemical Properties 6 1.3 Excited State Kinetics 8 1.3.1 Steady-State Emission 8 1.3.2 Time-Resolved Emission 10 1.4 Excited-State Reactivity of [Ru(bpy)3]2+ 11 1.5 Energy Transfer: Foerster and Dexter Mechanisms 12 1.6 Electron Transfer 14 1.7 Probing the Mechanism, Stage I: Stern-Volmer Quenching Studies 14 1.8 Probing the Mechanism, Stage II: Electron Versus Energy Transfer 16 1.9 Designing Photocatalysts: [Ru(bpy)3]2+ as a Starting Point 20 1.10 Conclusion 22 References 23
• 2 Visible-Light-Mediated Free Radical Synthesis 25 Louis Fensterbank, Jean-Philippe Goddard, and Cyril Ollivier 2.1 Introduction 25 2.2 Basics of the Photocatalytic Cycle 26 2.3 Generation of Radicals 27 2.3.1 Formation of C-Centered Radicals 27 2.3.1.1 Dehalogenation (I, Br, Cl) 27 2.3.1.2 Other C-Heteroatom Cleavage 29 2.3.1.3 C-C Bond Cleavage 29 2.3.2 Formation of N-Centered Radicals 30 2.4 C-X Bond Formation 30 2.4.1 C-O Bond 30 2.4.2 C-N Bond 32 2.4.3 C-S and C-Se Bonds 33 2.4.4 C-Br Bond 34 2.4.5 C-F Bond 34 2.4.6 C-B Bond 35 2.5 C-C Bond Formation 35 2.5.1 Formation and Reactivity of Aryl Radicals 35 2.5.2 Formation and Reactivity of Trifluoromethyl and Related Radicals 40 2.5.2.1 Photocatalyzed Reduction of Perfluorohalogen Derivatives 40 2.5.2.2 Photocatalyzed Reduction of Perfluoroalkyl-Substituted Onium Salts 42 2.5.2.3 Photocatalyzed Formation of Perfluoroalkyl Radicals from Sulfonyl and Sulfinyl Derivatives 43 2.5.3 Formation and Reactivity of Alkyl and Related Radicals 45 2.5.3.1 C-C Bond FormationThrough Photocatalyzed Reduction of Halogen Derivatives and Analogs 45 2.5.3.2 C-C Bond FormationThrough Photocatalyzed Oxidation of Electron-Rich Functional Group 47 2.5.3.3 C-C Bond FormationThrough Photocatalyzed Oxidation of Amino Group 48 2.6 Radical Cascade Applications 49 2.6.1 Intramolecular Polycyclization Processes 49 2.6.2 Sequential Inter- and Intramolecular Processes 51 2.6.3 Sequential Radical and Polar Processes 56 References 59
• 3 AtomTransfer Radical Addition using Photoredox Catalysis 73 Theresa M.Williams and Corey R. J. Stephenson 3.1 Introduction 73 3.2 Transition Metal-Catalyzed ATRA 77 3.2.1 Ruthenium- and Iridium-Based ATRA 77 3.2.1.1 Mechanistic Investigations 77 3.2.1.2 Ruthenium- and Iridium-Based ATRA 80 3.2.2 Copper-Mediated ATRA 81 3.2.2.1 Trifluoromethylation 82 3.3 Other Photocatalysts for ATRA Transformations 84 3.3.1 p-Anisaldehyde 84 3.4 Semiconductor 86 3.5 Atom Transfer Radical Cyclization (ATRC) 87 3.6 Atom Transfer Radical Polymerization (ATRP) 89 3.7 Conclusion 90 References 90
• 4 Visible Light Mediated -----Amino C-H Functionalization Reactions 93 You-Quan Zou andWen-Jing Xiao 4.1 Introduction 93 4.2 Visible Light Mediated -Amino C-H Functionalization Via Iminium Ions 95 4.2.1 Aza-Henry Reaction 95 4.2.2 Mannich Reaction 100 4.2.3 Strecker Reaction 104 4.2.4 Friedel-Crafts Reaction 105 4.2.5 Alkynylation Reaction 108 4.2.6 Phosphonation Reaction 109 4.2.7 Addition of 1,3-Dicarbonyls 109 4.2.8 Formation of C-N and C-O Bonds 110 4.2.9 Miscellaneous 112 4.3 Visible Light Mediated -Amino C-H Functionalization Via -Amino Radicals 116 4.3.1 Addition to Electron-Deficient Aromatics 116 4.3.2 Addition to Electron-Deficient Alkenes 116 4.3.3 Miscellaneous 120 4.4 Conclusions and Perspectives 121 References 122
• 5 Visible Light Mediated Cycloaddition Reactions 129 Scott Morris, Theresa Nguyen, and Nan Zheng 5.1 Introduction 129 5.2 [2+2] Cycloadditions: Formation of Four-Membered Rings 130 5.2.1 Introduction to [2+2] Cycloadditions 130 5.2.2 Utilization of the Reductive Quenching Cycle 130 5.2.3 Utilization of the Oxidative Quenching Cycle 135 5.2.4 Utilization of Energy Transfer 139 5.2.5 [2+2] Conclusion 142 5.3 [3+2] Cycloadditions: Formation of Five-Membered Rings 143 5.3.1 Introduction to [3+2] Cycloadditions 143 5.3.2 [3+2] Cycloaddition of Cyclopropylamines 143 5.3.3 1,3-Dipolar Cycloaddition of Azomethine Ylides 145 5.3.4 [3+2] Cycloaddition of Aryl Cyclopropyl Ketones 146 5.3.5 [3+2] Cycloaddition via ATRA/ATRC 146 5.3.6 [3+2] Conclusion 148 5.4 [4+2] Cycloadditions: Formation of Six-Membered Rings 149 5.4.1 Introduction to [4+2] Cycloadditions 149 5.4.2 [4+2] Cycloadditions Using Radical Anions 149 5.4.3 [4+2] Cycloadditions Using Radical Cations 151 5.4.4 [4+2] Conclusion 154 5.5 Conclusion 155 References 156
• 6 Metal-Free Photo(redox) Catalysis 159 Kirsten Zeitler 6.1 Introduction 159 6.1.1 Background 162 6.1.2 Classes of Organic Photocatalysts 162 6.2 Applications of Organic Photocatalysts 166 6.2.1 Energy Transfer Reactions 166 6.2.2 Reductive Quenching of the Catalyst 171 6.2.2.1 Cyanoarenes 171 6.2.2.2 Quinones 172 6.2.2.3 Cationic Dyes: Pyrylium, Quinolinium, and Acridinium Scaffolds 173 6.2.2.4 Xanthene Dyes and Further Aromatic Scaffolds 188 6.2.3 Oxidative Quenching of the Catalyst 203 6.2.4 New Developments 214 6.2.4.1 Upconversion 215 6.2.4.2 Consecutive Photoelectron Transfer 215 6.2.4.3 Multicatalysis 216 6.3 Conclusion and Outlook 224 References 224
• 7 Visible Light and Copper Complexes: A Promising Match in Photoredox Catalysis 233 Suva Paria and Oliver Reiser 7.1 Introduction 233 7.2 Photophysical Properties of Copper Catalysts 234 7.3 Application of Copper Based Photocatalysts in Organic Synthesis 237 7.4 Outlook 247 Acknowledgment 248 References 248
• 8 Arene Functionalization by Visible Light Photoredox Catalysis 253 Durga Hari Prasad, Thea Hering, and Burkhard Koenig 8.1 Introduction 253 8.1.1 Aryl Diazonium Salts 253 8.1.2 Diaryl Iodonium Salts 268 8.1.3 Triaryl Sulfonium Salts 272 8.1.4 Aryl Sulfonyl Chlorides 273 8.2 Applications of Aryl Diazonium Salts 274 8.3 Photoinduced Ullmann C-N Coupling 276 8.4 Conclusion 278 References 278
• 9 Visible-Light Photocatalysis in the Synthesis of Natural Products 283 Gregory L. Lackner, KyleW. Quasdorf, and Larry E. Overman References 295
• 10 Dual Photoredox Catalysis: TheMerger of Photoredox Catalysis with Other Catalytic Activation Modes 299 Christopher K. Prier and DavidW. C. MacMillan 10.1 Introduction 299 10.2 Merger of Photoredox Catalysis with Organocatalysis 300 10.3 Merger of Photoredox Catalysis with Acid Catalysis 314 10.3.1 Photoredox Catalysis and Bronsted Acid Catalysis 314 10.3.2 Photoredox Catalysis and Lewis Acid Catalysis 318 10.4 Merger of Photoredox Catalysis with Transition Metal Catalysis 320 10.5 Conclusions 328 References 328
• 11 Enantioselective Photocatalysis 335 Susannah C. Coote and Thorsten Bach 11.1 Introduction 335 11.2 The Twentieth Century: PioneeringWork 336 11.3 The Twenty-First Century: Contemporary Developments 341 11.3.1 Large-Molecule Chiral Hosts 341 11.3.2 Small-Molecule Chiral Photosensitizers 343 11.3.3 Lewis Acid-Mediated Photoreactions 353 11.4 Conclusions and Outlook 357 References 358
• 12 Photomediated Controlled Polymerizations 363 Nicolas J. Treat, Brett P. Fors, and Craig J. Hawker 12.1 Catalyst Activation by Light 365 12.1.1 Cu-Catalyzed Photoregulated Atom Transfer Radical Polymerizations (photoATRP) 365 12.1.2 Photomediated ATRP with Non-Copper-Based Catalyst Systems 368 12.1.3 Iodine-Mediated Photopolymerizations 371 12.1.4 Metal-Free Photomediated Ring-Opening Metathesis Polymerization 375 12.1.5 Photoregulated Reversible-Addition Fragmentation Chain Transfer Polymerizations (photoRAFT) 376 12.2 Chain-End Activation by Light 383 12.3 Conclusions 384 References 385
• 13 Accelerating Visible-Light Photoredox Catalysis in Continuous-Flow Reactors 389 Natan J.W. Straathof and Timothy Noel 13.1 Introduction 389 13.2 Homogeneous Photocatalysis in Single-Phase Flow 392 13.3 Gas-liquid Photocatalysis in Flow 401 13.4 Heterogeneous Photocatalysis in Flow 408 13.5 Conclusions 410 Conflict of Interest 410 References 410
• 14 The Application of Visible-Light-Mediated Reactions to the Synthesis of Pharmaceutical Compounds 415 James. J. Douglas 14.1 Introduction 415 14.2 Asymmetric Benzylation 415 14.3 Amide Bond Formation 416 14.4 C-H Azidation 417 14.5 Visible-Light-Mediated Benzothiophene Synthesis 418 14.6 -Amino Radical Functionalization 419 14.7 Visible-Light-Mediated Radical Smiles Rearrangement 422 14.8 Photoredox and Nickel Dual Catalysis 423 14.9 The Scale-Up of Visible-Light-Mediated Reactions Via Continuous Processing 426 References 428 Index 431.
• (source: Nielsen Book Data)

• FUNDAMENTAL ASPECTS OF PHOTOCATALYSIS: ENERGY TRANSFER AND ELECTRON TRANSFER MECHANISMS (PHOTOPHYSICAL AND ELECTROCHEMICAL PROPERTIES OF PHOTOREDOX COMPLEXES)
• APPLICATIONS IN ORGANIC SYNTHESIS: AN HISTORICAL PERSPECTIVE
• ENANTIOSELECTIVE PHOTOCATALYSIS
• PHOTOREDOX ORGANOCATALYSIS
• CYCLOADDITION REACTIONS
• C-H FUNCTIONALIZATION
• METAL-FREE PHOTOREDOX CATALYSIS
• PHOTOCATALYTIC POLYMERIZATION
• BIMETALLIC/CO-CATALYSIS
• FREE RADICAL CHEMISTRY
• ARENE FUNCTIONALIZATIONS
• TECHNOLOGY APPLICATIONS IN PHOTOCHEMISTRY
• SEMICONDUCTOR PHOTOCATALYSIS
• APPLICATIONS IN COMPLEX MOLECULE SYNTHESIS.
• (source: Nielsen Book Data)

Filling the need for a ready reference that reflects the vast developments in this field, this book presents everything from fundamentals, applications, various reaction types, and technical applications. Edited by rising stars in the scientific community, the text focuses solely on visible light photocatalysis in the context of organic chemistry. This primarily entails photoinduced electron transfer and energy transfer chemistry sensitized by polypyridyl complexes, yet also includes the use of organic dyes and heterogeneous catalysts. A valuable resource to the synthetic organic community, polymer and medicinal chemists, as well as industry professionals.
(source: Nielsen Book Data)

This book provides state-of-the-art information on how studies in applied theoretical organic chemistry are conducted. It highlights the many approaches and tools available to those interested in using computational chemistry to predict and rationalize structures and reactivity of organic molecules. Chapters not only describe theoretical techniques in detail, but also describe recent applications and offer practical advice. Authored by many of the world leaders in the field of applied theoretical chemistry, this book is perfect for both practitioners of computational chemistry and synthetic and mechanistic organic chemists curious about applying computational techniques to their research.
(source: Nielsen Book Data)

• Front Cover; Nuclear Magnetic Resonance and Infrared Spectroscopy; Copyright Page; Table of Contents; CONTRIBUTORS TO VOLUME 1; PREFACE; FOREWORD;
• Chapter 1. AN INTRODUCTION TO HIGH RESOLUTION NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; 1. Introduction; 2. Basic Instrumentation; 3. Chemical Shifts; 4. Spin-spin Coupling; 5. Intensity Measurements; 6. Dynamic Processes; 7. The Analysis of Spectra; 8. Analytical Aids; References; Bibliography;
• Chapter 2. APPLICATIONS OF NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY IN ORGANIC CHEMISTRY; Introduction.

• TABLE 6 PROTON CHEMICAL SHIFTS IN MONOSUBSTITUTED BENZENES Relative to Benzene, 2-73 tTABLE 7a PROTON CHEMICAL SHIFTS (t) IN para-DISUBSTITUTED BENZENES FOR H Relative to Benzene, 2-73 t ; TABLE 7b PROTON CHEMICAL SHIFTS (t) IN meta-DISUBSTITUTED BENZENES Relative to Benzene, 2-73 t; TABLE 8 t-VALUES OF ACIDIC PROTONS ( -OH, NH, and -SH); TABLE 9 PROTON SPIN-COUPLING CONSTANTS; TABLE 10 t-VALUES OF SOME SOLVENTS; CORRELATION OF DIHEDRAL ANGLE WITH COUPLING CONSTANTJHH A TYPICAL EXAMPLE;
• Chapter 4. NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY SEMINAR PROBLEMS AND ANSWERS.

• Answers to NMR Seminar ProblemsReferences;
• Chapter 5. THE THEORETICAL BASIS OF INFRARED SPECTROSCOPY; 1. The Normal Modes of Vibration of Molecules; 2. Vibration Frequencies and Properties of Molecules; 3. The Infrared and Raman Spectra of Molecules; 4. Characteristic Frequencies of Organic Molecules; 5. The Infrared Spectra of Complex Molecules; References;
• Chapter 6. APPLICATIONS OF INFRARED SPECTROSCOPY TO ORGANIC CHEMISTRY; Regions of Absorption; Interpretation; Conclusion;
• Chapter 7. INFRARED SPECTROSCOPIC PROBLEMS AND ANSWERS; Infrared Spectroscopic Problems.

• Answers to Infrared Spectroscopic ProblemsReference;
• Chapter 8. CORRELATION TABLES FOR INFRARED SPECTRA; TABLE 1 METHYL GROUPS; TABLE 2 METHYLENE GROUPS; TABLE 3 METHINE GROUPS; TABLE 4 ALKENES AND DOUBLE-BONDED CARBON; TABLE 5 PHENYL NUCLEUS; TABLE 6 TRIPLE BONDS; TABLE 7 CARBONYL GROUPS; TABLE 8 HYDROXYL GROUPS; TABLE 9 -NH GROUPS; TABLE 10 ETHERS; TABLE 11 C=N AND N = N GROUPS; TABLE 12 NITRO, NITROSO AND N-OXIDES; TABLE 13 SULPHUR COMPOUNDS; TABLE 14 PHOSPHORUS COMPOUNDS; TABLE 15 SILICON COMPOUNDS; TABLE 16 HALIDES AND INORGANIC IONS; Index to Correlation Tables by Wavelength.

• Approaches to the Interpretation of Proton Magnetic Resonance SpectraExamples of Applications; Conclusion; References;
• Chapter 3. CORRELATION TABLES FOR NUCLEAR MAGNETIC RESONANCE SPECTRA; TABLE 1 t-VALUES OF α-PROTONS IN SUBSTITUTED ALKANES; TABLE 2 DESHIELDING OF ALKYL PROTONS BY B-SUBSTITUENTS Relative to 9-1 ô (CH3), 8-75 ô (CH2), and 8-5 ô (CH); TABLE 3 SHIELDING CONSTANTS FOR DISUBSTITUTED METHYLENES; TABLE 4 APPROXIMATE T-VALUES FOR H ATTACHED TO UNSATURATED AND AROMATIC GROUPS; TABLE 5 t-VALUES FOR PROTONS ATTACHED TO DOUBLE BONDS.

An Introduction to Spectroscopic Methods for the Identification of Organic Compounds.

• Chemical Bonding and Molecular Structure.- Stereochemistry, Conformation, and Stereoselectivity.- Structural Effects on Stability and Reactivity.- Nucleophilic Substitution.- Polar Addition and Elimination Reactions.- Carbanions and Other Carbon Nucleophiles.- Addition, Condensation and Substitution Reactions of Carbonyl Compounds.- Aromaticity.- Aromatic Substitution.- Concerted Pericyclic Reactions.- Free Radical Reactions.- Photochemistry.
• (source: Nielsen Book Data)

The two-part, fifth edition of Advanced Organic Chemistry has been substantially revised and reorganized for greater clarity. The material has been updated to reflect advances in the field since the previous edition, especially in computational chemistry. Part A covers fundamental structural topics and basic mechanistic types. It can stand-alone; together, with Part B: Reaction and Synthesis, the two volumes provide a comprehensive foundation for the study in organic chemistry. Companion websites provide digital models for study of structure, reaction and selectivity for students and exercise solutions for instructors.
(source: Nielsen Book Data)

• Selected Problems: A tandem route to 1,2,3,4-tetrasubstituted naphthalenes. The Hooker oxidation. Benzopyrene synthesis - by accident. Lactone ammonolysis. Acid-catalysed condensation of indole with acetone. Flash vacuum pyrolysis of o-xylylene dimers. A "stable enol" that doesn't exist. Reaction of benzothiazole with DMAD. Ring contractions of a dibenzothiepinone. Rearrangement of 6-hydroxyprotopine to dihydrosanguinarine. An intramolecular Wittig reaction. Easy contruction of a tricyclic indole related to the mitomycins. A flavone from a chromanone. Lewis acid-catalysed condensation of indole with 1,3-cyclohexanedione. Two syntheses of dehydrorotenone.
• (source: Nielsen Book Data)

The Elsevier Tetrahedron Organic Chemistry Series is a topical series of monographs by world-renowned scientists in several fields of organic chemistry. The Tetrahedron Organic Chemistry Series has been very successful in providing some of the very best scholarly works in these topical areas that have proven to be of lasting quality as indispensable reference sources. These books have provided the practicing researcher, student and scholar with an invaluable source of comprehensive reviews in organic chemistry, predominantly in the areas of synthesis and structure determination, including: * Reagents * Reaction mechanisms * Molecular Diversity * Asymmetric Synthesis * Multi-dimensional nmr * Enzymatic Synthesis * Organometallic Chemistry * Biologically Important Molecules.
(source: Nielsen Book Data)

• Preface xi
• Preface to the First Edition xvii
• Acknowledgments xix
• 1 Problem Analysis in Organic Reaction Mechanism 1
• 1.1 Overview, 1
• 1.2 Introduction, 1
• 1.2.1 "Pushing Forward" a Solution in Formal and Exhaustive Terms, 2
• 1.2.2 Lessons from this Example, 7
• 1.3 Avoiding the Quagmire, 7
• 1.4 The Basic Steps of Problem Analysis, 8
• 1.4.1 Recognizing the Problem, 8
• 1.4.2 Analyzing Problems by Asking the Right Questions, Discarding the Irrelevant, 11
• 1.4.3 Drawing a First Outline for Guidance, 12
• 1.4.4 Asking the Right Questions and Proposing the Right Answers . . . is enough?, 13
• 1.5 Intuition and Problem Solving, 14
• 1.6 Summing Up, 17
• References and Notes, 17
• 2 Electron Flow in Organic Reactions 19
• 2.1 Overview, 19
• 2.2 Introduction, 19
• 2.3 Practical Rules Governing Electron Redeployment, 22
• 2.3.1 Issue 1: Electrons within Orbitals, 22
• 2.3.2 Issue 2: Electron Transfer and Stereochemistry, 23
• 2.3.3 Issue 3: Electron Energy Level and Accessibility, 24
• 2.3.4 Issue 4: Electron Flow and Molecular Active Sectors, 26
• 2.3.4.1 Case A:
• Interactions, 26
• 2.3.4.2 Case B.:
• Interactions, 27
• 2.3.4.3 Case C: When Reactivity Patterns Seem to Break Down, 27
• 2.3.5 Issue 5: Electron Traffic and Electronic Density Differences, 31
• 2.3.5.1 M0 Metals as Electron Source, 31
• 2.3.5.2 Metal Hydrides and Organic Hydrides as Electron Source, 32
• 2.3.6 Issue 6: Creating Zones of High Electron Density, 34
• 2.3.6.1 The Natural Polarization, 35
• 2.3.6.2 Reversing the Natural Polarization: Umpolung, 35
• 2.3.7 Issue 7: Electron Flow and Low Electron Density Zones, 36
• 2.3.7.1 Identifying LEDZs, 36
• 2.3.7.2 Creating a New LEDZ in the Substrate, 37
• 2.3.7.3 Finding Unsuspected LEDZs among the Other Reagents in the Mixture, 41
• 2.3.7.4 When Compounds Show Double Personality, 42
• 2.4 Summing Up, 42
• 2.5 A Flowchart of Organized Problem Analysis, 44
• References and Notes, 45
• 3 Additional Techniques to Postulate Organic Reaction Mechanisms 49
• 3.1 Overview, 49
• 3.2 Take Your Time, 50
• 3.3 Clear and Informative Molecular Renderings, 50
• 3.3.1 The Value of Molecular Sketches, 50
• 3.3.2 Two- Versus Three-Dimensional Renderings and the "Flat" Organic Compounds, 52
• 3.4 Element and Bond Budgets, 53
• 3.5 Looking at Molecules from Various Perspectives, 55
• 3.6 Separate the Grain from the Chaff, 58
• 3.7 Dissecting Products in Terms of Reactants: Fragmentation Analysis, 59
• 3.7.1 The Fundamental Proposition, 59
• 3.7.2 Adding Potentially Nucleophilic or Electrophilic Character to Fragments, 61
• 3.7.3 When Fragmentation Analysis Fails, Getting Help from Atom Labels, 63
• 3.8 Oxidation Levels and Mechanism, 65
• 3.8.1 Methods to Estimate Oxidation Status, 65
• 3.9 The Functionality Number, 66
• 3.9.1 What Exactly Is FN?, 66
• 3.9.2 Properties of FN, 67
• 3.10 Combining Fragmentation Analysis and Functionality Numbers, 72
• 3.11 Summing Up, 74
• References, 75
• 4 Solved Problem Collection 77
• Problem 1 to 60. See Graphical Problem Index, 79
• Glossary 405
• Subject/Reaction Index 409
• Reagent Index 425
• Author Index 433
• Graphical Problem Index 445.
• (source: Nielsen Book Data)

This long-awaited new edition helps students understand and solve the complex problems that organic chemists regularly face, using a step-by-step method and approachable text. With solved and worked-through problems, the author orients discussion of each through the application of various problem-solving techniques. Teaches organic chemists structured and logical techniques to solve reaction problems and uses a unique, systematic approach. Stresses the logic and strategy of mechanistic problem solving -- a key piece of success for organic chemistry, beyond just specific reactions and facts Has a conversational tone and acts as a readable and approachable workbook allowing reader involvement instead of simply straightforward text Uses 60 solved and worked-through problems and reaction schemes for students to practice with, along with updated organic reactions and illustrated examples Includes website with supplementary material for chapters and problems: http://tapsoc.yolasite.com.
(source: Nielsen Book Data)