Book — 1 online resource (288 pages) : illustrations.
Introduction.- Background.- Development of a new model for simulating the electrical action potentials of human atrial myocytes.- Development of a family of regional cell models.- Autonomic regulation and pathophysiological remodelling.- 3D Anatomical Modelling of the Atria.- Pacemaking and autonomic regulation in the 3D sinoatrial node and atria.- Atrial Fibrillation.- Discussion.
(source: Nielsen Book Data)
This thesis describes the development of biophysically detailed computer models of the human atria and torso to study the underlying mechanisms of cardiac diseases, some of the most common causes of morbidity and mortality. This is a cross-disciplinary project, involving fundamentals of cardiac electrophysiology, physics of excitable media, applied mathematics and high performance scientific computing and visualisation. The author uses computer models to provide insights into the underlying mechanisms of the genesis of atrial fibrillation and develops novel techniques for the monitoring of atrial tachycardia. (source: Nielsen Book Data) 9783319016429 20160612
9. Potential further developments and applications
Bernhard Gleich introduces Magnetic Particle Imaging (MPI) including all aspects that are necessary for a complete understanding. MPI is a new imaging modality invented by Bernhard Gleich and Jrgen Weizenecker. The method is capable of imaging the distribution of superparamagnetic iron oxide particles (SPIOs) with high sensitivity, high spatial resolution, and high imaging speed. The author summarizes the results of a number of original papers and countless innovations he has elaborated in the young discipline of magnetic particle imaging.
Physical and Technical Background.- Image Reconstruction in MRI.- Overview of PatLoc Imaging and Presentation of Initial Hardware Designs.- Basics of Signal Encoding and Image Reconstruction in PatLoc Imaging.- Direct Reconstruction for Cartesian PatLoc Imaging.- Direct Reconstruction for Radial PatLoc Imaging.- Iterative Reconstruction in PatLoc Imaging.- Summary and Outlook.
(source: Nielsen Book Data)
Within the past few decades MRI has become one of the most important imaging modalities in medicine. For a reliable diagnosis of pathologies further technological improvements are of primary importance. This study deals with a radically new approach of image encoding. Gradient linearity has ever since been an unquestioned technological design criterion. With the advent of parallel imaging, this approach may be questioned, making way of much a more flexible gradient hardware that uses encoding fields with an arbitrary geometry. The theoretical basis of this new imaging modality - PatLoc imaging - are comprehensively presented, suitable image reconstruction algorithms are developed for a variety of imaging sequences and imaging results - including in vivo data - are explored based on novel hardware designs. (source: Nielsen Book Data) 9783658011338 20160610
Bernhard Gleich introduces Magnetic Particle Imaging (MPI) including all aspects that are necessary for a complete understanding. MPI is a new imaging modality invented by Bernhard Gleich and Jurgen Weizenecker. The method is capable of imaging the distribution of superparamagnetic iron oxide particles (SPIOs) with high sensitivity, high spatial resolution, and high imaging speed. The author summarizes the results of a number of original papers and countless innovations he has elaborated in the young discipline of magnetic particle imaging. (source: Nielsen Book Data) 9783658019600 20160612
1: On the Role of Melanoma-Specific CD8+ T-Cell Immunity in Disease Progression of Advanced-Stage Melanoma Patients.; Ch. 2:Phase I clinical study with multiple peptide vaccines in combination with tetanus toxoid and GM-CSF in advanced-stage HLA-A*0201- positive melanoma patients.; Ch.
3: A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression; Ch. 4:Superior immunogenicity of DNA tattooing as compared to intramuscular DNA vaccination in non-human primates.; Ch.
5: In vivo antigen stability affects vaccine efficacy.
In the last century, it has become clear that in patients suffering certain types of cancer, spontaneous activation of the immune sytem may lead to curation. The concept of immunotherapy is based on that notion. The intention is to stimulate T cells direc.