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1 online resource.
  • List of contributors xiii Foreword xvii Preface xix 1 Introduction: An overview of malaria and Plasmodium 1 Virander S. Chauhan, Chetan E. Chitnis, and Deepak Gaur History 1 The life cycle of Plasmodium 3 A significant milestone in malaria research: Adaptation of Plasmodium to laboratory culture 4 The advent of present day technologies and their applications in malaria research 5 Bibliography 6 2 Exoerythrocytic development of Plasmodium parasites 9 Volker T. Heussler, Annika Rennenberg, and Rebecca R. Stanway The sporozoite s journey from the skin to the liver 10 Sporozoite invasion 14 Parasite development 15 Protein export from the parasite into the host cell 20 Parasite egress 23 The role of innate immune responses during merosome formation 26 Acknowledgments 27 Bibliography 27 3 Molecular basis of erythrocyte invasion by Plasmodium merozoites 33 Deepak Gaur, Chetan E. Chitnis, and Virander S. Chauhan The structure of the merozoite 39 The steps of erythrocyte invasion 41 Redundancy and ligand receptor interactions that mediate parasite adhesion during erythrocyte invasion 57 Signaling events during erythrocyte invasion by malaria parasites 74 Summary and conclusions 75 Bibliography 75 4 The biology of malaria transmission 87 Robert E. Sinden Purpose 87 History 87 The current research agenda 88 Biology 88 Population dynamics 106 Transmission blocking interventions 110 Bibliography 114 5 Comparative and functional genomics of malaria parasites 125 Martine M. Zilversmit, Sittiporn Pattaradilokrat, and Xin zhuan Su An Introduction to Plasmodium genomes 125 Genome structure of malaria parasites 127 From genome sequences to gene function 133 Summary 139 Acknowledgments 139 Bibliography 139 6 Gene regulation: New insights and possible intervention strategies 149 Artur Scherf, Nicholas A. Malmquist, Rafael M. Martins, Shruthi S. Vembar, and Jose Juan Lopez Rubio Introduction 149 Modes of gene regulation 150 Drug targeting 164 Perspectives 169 Bibliography 171 7 Molecular genetic approaches to malaria research 179 Brendan Elsworth, Mauro F. Azevedo, Brendan S. Crabb, and Paul R. Gilson Transfection methods 179 Genetic approaches for deriving gene function 184 Conditional knockdown of protein function 187 Protein reporters 190 Conclusions 192 Bibliography 192 8 Transcriptomics and proteomics 197 Archana P. Gupta, Zbynek Bozdech, and Peter R. Preiser Transcriptional profiling throughout the parasite life cycle 198 Transcriptional regulation 201 Transcriptional variation 205 Biological insights 208 Proteomics 208 Translational regulation 209 Conclusion 212 Bibliography 212 9 The biochemistry of Plasmodium falciparum: An updated overview 219 Hagai Ginsburg MPMP 219 Carbohydrates 219 Lipid metabolism 227 Amino acids 240 Nucleotide metabolism 252 Cofactors 256 Redox metabolism 265 Mitochondrial functions 268 Hemoglobin digestion and hemozoin production 273 Some reflections for the future 276 Bibliography 277 10 Signaling in malaria parasites 291 Pushkar Sharma and Sudhir Kumar Protein phosphorylation in Plasmodium 291 Calcium mediated signaling in Plasmodium 292 Phosphoinositide signaling and trafficking in malaria parasites 295 Cyclic nucleotide signaling in the malaria parasite 296 Future challenges 300 Bibliography 300 11 Membrane transport proteins as therapeutic targets in malaria 307 Sanjay A. Desai, Kempaiah Rayavara, Paresh Sharma, Sayeed K. Syed, Wang Nguitragool, and Praveen Balabaskaran Nina Host erythrocyte membrane: A shared ion and nutrient channel 308 Parasitophorous vacuolar membrane: Protein export and solute uptake 311 Parasite plasma membrane: Similar to other eukaryotic cells, but different 314 Digestive vacuole: A specialized lysosome equivalent in the parasite 316 Mitochondrial inner membrane: An unusual ATP synthase with uncertain function 318 Conclusions 319 Acknowledgments 319 Bibliography 319 12 The proteolytic repertoire of malaria parasites 325 Puran Singh Sijwali and Philip J. Rosenthal Aspartic proteases 325 Cysteine proteases 330 Metalloproteases 333 Serine proteases 335 Threonine proteases 338 Roles of proteases in parasite development 340 Summary and conclusions 343 Acknowledgments 343 Bibliography 343 13 Development of medicines for the control and elimination of malaria 353 Jeremy N. Burrows and Timothy N. C. Wells Targets for the development of future medicines for malaria 356 The process of drug development 359 Advances in drug development made in the 21st century 365 The global pipeline of new medicines for treating malaria 368 Medicines in the broader context of malaria eradication 370 Conclusion 377 Acknowledgments 377 Bibliography 377 14 Antimalarial drug resistance 383 Naman K. Shah and Neena Valecha Background 383 Causes of drug resistance 386 Detection of drug resistance 390 Managing drug resistance 397 Conclusion 401 Disclosures 401 Bibliography 401 Further reading 407 15 Epidemiology of Plasmodium falciparum malaria 409 Alberto L. Garcia Basteiro, Quique Bassat, and Pedro L. Alonso Burden of disease 409 Geographical distribution of the disease 411 Chain of transmission and infection cycle 413 Malaria endemicity and malaria transmission 415 Malaria elimination and eradication 423 Bibliography 424 16 Malaria pathogenesis 427 Bronner P. Goncalves, Michal Fried, and Patrick E. Duffy Malaria illness 427 Host susceptibility 439 Parasite virulence 444 Conclusions 450 Bibliography 451 17 Host genetics 465 Thomas N. Williams What evidence is there that the risk of malaria is genetically determined? 465 Identifying the genes involved 466 Why is genetic resistance important? 467 Genetic polymorphisms of the red blood cell 468 Hemoglobinopathies 474 G6PD deficiency 478 Non red blood cell polymorphisms 479 Concluding remarks 481 Bibliography 481 18 The immune response in mild and severe malaria: Two sides of the same coin 495 Michael Waisberg, Peter D. Crompton, Louis H. Miller, and Susan K. Pierce The picture of the acquisition of resistance to uncomplicated and severe malaria: Framing the questions 495 Searching for host genes that confer immune resistance to severe malaria 506 SLE susceptibility and resistance to severe malaria 507 The relationship between the pathogen environment and susceptibility to severe malaria 510 Summary 511 Acknowledgments 511 Bibliography 512 19 Progress in development of malaria vaccines 521 Chetan E. Chitnis, Deepak Gaur, and Virander S. Chauhan Immunity to malaria 521 Life cycle of malaria parasites and points of intervention with vaccines 522 Pre erythrocytic stage vaccines 524 Blood stage vaccines 526 Transmission blocking vaccines 533 Live attenuated vaccines for malaria 534 Conclusion 535 Bibliography 535 20 Plasmodium vivax: Insights on burden and pathobiology 547 Ivo Mueller, Quique Bassat, Marcus V. G. Lacerda, and Hernando A. del Portillo Burden of Plasmodium vivax infection and disease 547 Severe Plasmodium vivax malaria 550 Molecular basis of severe disease 552 Concluding remarks and outstanding research questions 558 Bibliography 558 Index 565.
  • (source: Nielsen Book Data)9781118493793 20170313
This title explores malarial biology with insights from post-genomic technologies. The book looks broadly at the disease, vectors of infection, and treatment and prevention strategies.
(source: Nielsen Book Data)9781118493793 20170313
1 online resource (xii, 404 pages.) :.
The book presents recent developments and application of fluorescent protein-labelling techniques and two-photon molecular probes. It introduces research of super-resolution localization microscopy, photoacoustic molecular (functional) imaging, and optical molecular tomography for small animal in vivo. The book illustrates optical labeling techniques and imaging instruments and their application in biological studies.
(source: Nielsen Book Data)9783110304381 20170814
1 online resource.
  • 1. Nanomedicine for delivery of therapeutic molecules 2. Nanoparticles as nucleic acid delivery vectors 3. Methods for characterization of nanoparticles 4. Nanoparticles for DNA delivery 5. Nanoparticles for siRNA-mediated gene silencing 6. Nanoparticles for locked nucleic acid delivery 7. Nanoparticles for ribozymes delivery 8. Nanoparticles for DNAzymes delivery 9. Pharmacokinetics and biodistribution of the nanoparticles 10. Nanotoxicology: Evaluation of toxicity potential of nanoparticles 11. Regulatory aspects of nanoparticulate mediated nucleic acid delivery systems 12. Clinical studies and future prospects.
  • (source: Nielsen Book Data)9780081005576 20170515
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc.
(source: Nielsen Book Data)9780081005576 20170515
viii, 271 pages : illustrations (some color), charts ; 25 cm
  • Combining radiotherapy and immunotherapy
  • SBRT and the treatment of oligometastatic disease
  • MRI guided radiotherapy
  • Oncologic applications of magnetic resonance guided focused ultrasound
  • Intensity-modulated proton beam therapy of prostate cancer- history, results, and future directions
  • IGRT and hypofractionation for primary tumors
  • The impact of IGRT on normal tissue toxicity
  • Biologic and image guided systemic radiotherapy
  • Cancer stem cells and tumor microenvironment in radiotherapy
  • Biomarkers and radiotherapy
  • The mammalian DNA damage response as a target for therapeutic gain in radiation oncology
  • Mathematical modeling in radiation oncology.
Medical Library (Lane)
1 online resource (349 pages) : illustrations.
  • Understanding your learner: conducting a learner analysis / Tina M. Souders
  • Instructional strategies and sequencing / Thomas W. Lamey, Gayle V. Davidson-Shivers
  • Using backward design for competency-based undergraduate medical education / Barbara L. Joyce, Stephanie M. Swanberg
  • Designing simulated learning environments and facilitating authentic learning experiences in medical education / Xun Ge, Qian Wang [and 3 others]
  • Medical simulation as an instructional tool in health education: a worked example for clinical training / Anna Lerant [and 6 others]
  • The nurse educator's role in designing instruction and instructional strategies for academic and clinical settings / Patricia J. Slagter van Tryon
  • Online applied learning in nursing education / Beth Oyarzun, Elizabeth A. Gazza
  • Teaching residents how to teach / Heidi Kromrei, William L. Solomonson, Mark S. Juzych
  • Interprofessional education / Rebecca Moote
  • Introducing collaborative care: teaching basics of interprofessional education in an online environment / Joy Doll [and 8 others]
  • Informal learning in medical education / Misa Mi
  • Virtual patients in health professions education / A. J. Kleinheksel
  • Development and evaluation of neuroscience computer-based modules for medical students: instructional design principles and effectiveness / Kathryn L. Lovell
  • Faculty development for clinical educators: a competency model for continuous improvement / Silvia Lizett Olivares Olivares [and 3 others].
"This book provides individuals who work in the area of medical education with an instructional book that can serve as a tool kit for developing instruction in healthcare environments. The book covers topics related to conducting a needs assessment, analyzing performance, instructional theory, developing instructional materials, and tips for managing instructional projects"--Provided by publisher.
1 online resource (358 pages) : illustrations.
  • Ion channels, nanomechanics, and nanomedicine / Keka Talukdar
  • Analysis of the bacterial vesicles' enhanced toxicological threat via electron microscopy / Roberta Curia [and 5 others]
  • Applications of polymeric micro- and nano-particles in dentistry / Balasankar Meera Priyadarshini, Nileshkumar Dubey
  • Sensing the presence and amount of microbes using double walled carbon nanotubes / Anand Y Joshi, Ajay M Patel
  • CNS targeted nanoparticle drug delivery: CNS drug delivery / Dimple Sethi Chopra
  • Silver oxide-copper oxide nanocomposite preparation and antimicrobial activity as a source for the treatment of fish diseases: silver oxide-copper oxide nanocomposite preparation and antimicrobial activity / Sayed Reza Shaffiey, Sayedeh Fatemeh Shaffiey
  • Performance analysis of FET-based nanoiosensors by computational method / Keka Talukdar, Anil Shantappa Malipatil
  • Self-setting calcium phosphate bone cement preparation, characterization and drug delivery for skeletal system / Sayed Reza Shaffiey, Sayedeh Fatemeh Shaffiey
  • Mineralized nanofibers for bone tissue engineering / Ozan Karaman
  • Recent advances in synthesis and biomedical applications of magnetic nanoparticles: magnetic nanoparticles for biomedical applications / Irshad Ahmad Wani
  • Stratagems of nanotechnology augmenting the bioavailability and therapeutic efficacy of traditional medicine to formulate smart herbal drugs combating / Anita Margret.
The application of nanotechnology within the medical sphere has had a significant influence on how diseases and conditions are treated and diagnosed. While many strides have been made, there is still continuous research on nanotechnology being performed in the field. Advancing Medicine through Nanotechnology and Nanomechanics Applications highlights emergent trends and empirical research on technological innovations in medicine and healthcare. Investigating the impact of nanotechnology and nanomechanics on the treatment of diseases, regenerative medicine, and drug delivery systems, this publication is a vital reference source for professionals, researchers, medical students, and engineering students.
(source: Nielsen Book Data)9781522510437 20161213
1 online resource.
  • Section A: Engineered nanomaterials: Hazard, exposure, risk assessment 1. Bio-Nano Interactions 2. Physicochemical Characterization 3. Toxicity Tests: In Vitro and In Vivo 4. Computational Approaches 5. Exposure Assessment 6. Biomonitoring 7. Regulation and Legislation 8. Risk Assessment and Risk Management Section B: Engineered nanomaterials: Adverse effects on human health 9. Respiratory System, Part One: Basic Mechanisms 10. Respiratory System, Part Two: Allergy and Asthma 11. Cardiovascular System 12. Neurological System 13. Immune System 14. Endocrine System 15. Skin 16. Gastrointestinal System 17. Reproduction and Development 18. Genotoxicity and Cancer.
  • (source: Nielsen Book Data)9780128091999 20170410
Adverse Effects of Engineered Nanomaterials: Exposure, Toxicology, and Impact on Human Health, Second Edition, provides a systematic evaluation of representative engineered nanomaterials (ENM) of high volume production and their high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies, and the general public need to know about nanosafety. Written by leading international experts in nanotoxicology and nanomedicine, this book gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers, and patients. All chapters have been updated with new sections on the endocrine system and other organ systems. In addition, other newly added sections include introductory chapters on the physio-chemical characterization of nanomaterials and interactions between nanomaterials and biological systems, as well as a new chapter that explores risk assessment and management of nanomaterials. This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, also detailing the clinical and pathological consequences of such exposure in the human population.
(source: Nielsen Book Data)9780128091999 20170410
1 online resource.
  • Part I: General Aspects 1. Introduction 2. Protein and Lipid Kinases 3. Kinase Inhibitors 4. Adverse Events Part II: Oncotargeted Kinase Inhibitors 5. Imatinib 6. Gefitinib 7. Erlotinib 8. Sorafenib 9. Sunitinib 10. Dasatinib 11. Lapatinib 12. Nilotinib 13. Pazopanib 14. Vandetanib 15. Vemurafenib 16. Crizotinib 17. Ruxolitinib 18. Axitinib 19. Bosutinib 20. Regorafenib 21. Cabozantinib 22. Ponatinib 23. Dabrafenib 24. Trametinib 25. Adatinib 26. Idelalisib 27. Ibrutinib Part III: Overview 28. Kinase Inhibitors as Adverse Event Inducers 29. Kinase Inhibitors as Drug Class Events 30. Conclusion and Perspectives.
  • (source: Nielsen Book Data)9780128094006 20170612
Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class that has recently been introduced for human therapy. This book compiles a comprehensive safety profile of each TKI from experiences in official therapeutic indications, also exploring off-label exploratory investigations and postmarketing pharmaceutical surveillance databases. A brief history of each drug's development and submission is provided, along with a more detailed analysis of the mechanism(s) of action involved in therapeutic activity or related to the insurgence of specific adverse events. Early chapters focus on general characteristics of TKIs, typology, and classification of adverse events, while the final chapters analyze TKIs as AE inducers and classes of AEs by system or organ involvement. This comprehensive resource compiles and critically reviews all of the relevant safety data for this class of drugs, with the goal of improving the understanding of pathogenesis and facilitating the prevention, monitoring, and management of these adverse events.
(source: Nielsen Book Data)9780128094006 20170612
1 online resource
  • Sample Proportions and the Normal Distribution. Developing Competence in Working With LGBTQI+ Communities: Awareness, Knowledge, Skills, and Action / Misty M Ginicola, Cheri Smith, Joel M Filmore
  • The Science of Gender and Affectional Orientation / Misty M Ginicola
  • Growing Up LGBTQI+: The Importance of Developmental Conceptualizations / Anneliese A Singh, Kristopher M Goodrich, Amney J Harper, Melissa Luke
  • LGBTQI+ Youth Development / Melissa Luke, Amney J Harper, Kristopher M Goodrich, Anneliese A Singh
  • LGBTQI+ Persons in Adulthood / Amy Moore-Ramirez, Melanie Kautzman-East, Misty M Ginicola
  • Identity Development, Coming Out, and Family Adjustment / Kristopher M Goodrich, Misty M Ginicola
  • Physical and Mental Health Challenges Found in the LGBTQI+ Population / Misty M Ginicola, Joel M Filmore, Cheri Smith, Jahaan Abdullah
  • Disaffirming Therapy: The Ascent and Descent of Sexual Orientation Change Efforts / Peter Finnerty, Michael M Kocet, Jeff Lutes, Chad Yates
  • Evidence-Based Practice for Counseling the LGBTQI+ Population / Kristopher M Goodrich, Misty M Ginicola
  • Affirmative, Strengths-Based Counseling With LGBTQI+ People / Peter Finnerty, Michael M Kocet, Jeff Lutes, Chad Yates
  • Counseling Lesbian Clients / Cindy Anderton, Lindsay Woodbridge
  • Counseling Gay Male Clients / Misty M Ginicola, Samuel Sanabria, Joel M Filmore, Michael DeVoll
  • Counseling Bisexual/Pansexual/Polysexual Clients / Amney J Harper, Misty M Ginicola
  • Counseling Transgender Clients / Robyn Brammer, Misty M Ginicola
  • Counseling Queer and Genderqueer Clients / Jeffry Moe, Jamie Bower, Madeline Clark
  • Counseling Clients Questioning Their Affectional Orientation / Jared S Rose, Eric R Baltrinic
  • Counseling Intersex Clients / Misty M Ginicola
  • Sample Means and the Normal Distribution. Counseling Asexual Clients / Misty M Ginicola, Angela Ruggiero
  • Counseling Two-Spirit Clients / Misty M Ginicola
  • Counseling an LGBTQI+ Person of Color / Joel M Filmore, Misty M Ginicola
  • Counseling LGBTQI+ Immigrants / David Barreto, Amy Moore-Ramirez, Melanie Kautzman-East, Ryan Liberati
  • The Role of Religion and Spirituality in Counseling the LGBTQI+ Client / Misty M Ginicola, Brett H Furth, Cheri Smith
  • The GRACE Model of Counseling: Navigating Intersections of Affectional Orientation and Christian Spirituality / R Lewis Bozard, Cody J Sanders
  • Working With LGBTQI+ Clients Who Have Experienced Religious and Spiritual Abuse Using a Trauma-Informed Approach / Misty M Ginicola, Joel M Filmore, Michael Stokes
  • Becoming an Ally: Personal, Clinical, and School-Based Social Justice Interventions / Diane Estrada, Anneliese A Singh, Amney J Harper.
xv, 274 pages ; 26 cm.
  • Gender and sexual orientation diversity within the TGNC community / Sand C. Chang, Anneliese A. Singh, and Kinton Rossman
  • Affirmative counseling with trans/gender-variant people of color / Anneliese A. Singh, Sel J. Hwahng, Sand C. Chang, and Bali White
  • TGNC-affirmative interdisciplinary collaborative care / Kelly Ducheny, Michael L. Hendricks, and Colton L. Keo-Meier
  • Ethical and legal concerns for mental health professionals / Linda F. Campbell and Gabriel Arkles
  • Affirmative care of TGNC children and adolescents / Laura Edwards-Leeper
  • Working with TGNC primary caregivers and family concerns across the lifespan / Sand C. Chang, Jessie R. Cohen, and Anneliese A. Singh
  • Aging and TGNC identities : working with older adults / lore m. dickey and Kyle L. Bower
  • Clinical supervision with TGNC clients in health service psychology / Theodore R. Burnes, Stacie Fishell Rowan, and Parrish L. Paul
  • Assessment and treatment of trauma with TGNC clients : a feminist approach / Katherine Richmond, Theodore R. Burnes, Anneliese A. Singh, and Mel Ferrara
  • Spirituality, faith, and religion : the TGNC experience / Ruben A. Hopwood and Tarynn M. Witten
  • Engaging in TGNC-affirmative research / Jae Sevelius, lore m. dickey, and Anneliese A. Singh
  • Advocacy and social justice : the next generation of counseling and psychological practice with transgender and gender-nonconforming clients / lore m. dickey, Anneliese A. Singh, Sand C. Chang, and Mich Rehrig.
Less than 30% of psychologists report familiarity with transgender and gender nonconforming (TGNC) clients' needs. The clients, in turn, report a lack of support in their gender journeys. There is clearly a large gap in knowledge, skill, and competence in this area of practice. This clinical guide fills that gap by providing mental health practitioners with an affirmative approach that emphasises a collaborative partnership guided by client-driven goals. An expert panel of contributors teaches readers strategies for working with a diverse array of TGNC clients, including adolescents, older adults, parents, and people of colour. Client factors, including sexual orientation, religious and spiritual beliefs, and traumatic experiences, are also given special attention. Readers will learn how to address the impact of the injustices TGNC people face in everyday life, work with clients' strengths to enhance their resilience and coping skills, and advocate for their rights to obtain mental and physical health services. They will also learn how to negotiate complex issues, such as interdisciplinary care, ethical and legal obligations, and gender-affirming surgeries and medications. The chapter authors draw from evidence-based theories and APA's "Guidelines for Psychological Practice With Transgender and Gender Nonconforming People (PDF, 462KB)" to help readers meet the latest standards of care.
(source: Nielsen Book Data)9781433823008 20161108
Green Library
viii, 270 pages : illustrations ; 24 cm
  • Introduction / William C. Olsen and Carolyn Sargent
  • Biomedicine and African healing
  • The value of secrets: pragmatic healers and proprietary knowledge / Stacey Langwick
  • Body and sunsum: stroke in Asante / William C. Olsen
  • Spirits and pills who are against children: medico-rituals and assisted reproductive technologies in a Tuareg couple's quest for parenthood / Susan J. Rasmussen
  • Science in the moral space of health and healing paradigms in western equatorial Africa / John M. Janzen
  • Medical pluralism revisted: a memoir / Brooke Grundfest Schoepf
  • Symptoms and therapeutic pluralities
  • Wishful doing: journeying in a Nigerian medical landscape / Ulrika Trovalla
  • The individualization of illness: bewitchment and the mental in postcolonial Tanzania / Koen Stroeken
  • Ihahamuka-PTSD in postgenocidal Rwanda: culture, continuity and change in Rwandan therapeutics / Christopher C. Taylor
  • Hospital ethnography
  • Ear infections, malnutrition, and circuitous health care treatments in Zaria, Nigeria / Elisha Renne
  • Therapeutic eclecticism and cancer care in a Kenyan hospital ward / Benson A. Mulemi
  • Elusive paths, fluid care: seeking healing and protection in the Republic of Benin / Carolyn Sargent and James Leslie Kennell
  • Legitimate care, dangerous care, and childbirth in an urban African community / Claire Wendland
  • Afterword / Arthur Kleinman.
In most places on the African continent, multiple health care options exist and patients draw on a therapeutic continuum that ranges from traditional medicine and religious healing to the latest in biomedical technology. The ethnographically based essays in this volume highlight African ways of perceiving sickness, making sense of and treating suffering, and thinking about health care to reveal the range and practice of everyday medicine in Africa through historical, political, and economic contexts.
(source: Nielsen Book Data)9780253024916 20170410
Green Library
1 online resource (x, 226 pages) : illustrations.
  • 1. Alcohol a double-edged sword: Health benefits with moderate consumption but a health hazard with excess alcohol intake 2. Drugs of abuse: An overview 3. Designer drugs including bath salts and spices 4. Combined alcohol and drug abuse: A potentially deadly mix 5. Link between environmental factors, personality factors, and addiction 6. Genetic polymorphisms of alcohol metabolizing enzymes associated with protection from or increased risk of alcohol abuse 7. Pharmacogenomics of abused drugs 8. Association between polymorphisms in genes encoding various receptors, transporters, and enzymes and alcohol/drug addiction 9. Methods of alcohol measurement 10. Laboratory methods for measuring drugs of abuse in urine 11. Analysis of drugs of abuse in serum, hair, oral fluid, sweat, and meconium.
  • (source: Nielsen Book Data)9780128054550 20170313
Alcohol, Drugs, Genes and the Clinical Laboratory provides an overview and quick reference to genetic relationships and clinical laboratory information related to the serious public health issue of alcohol and drug abuse. Written in a clear and concise manner, this book discusses the necessary information for health and safety professionals working in public health to learn about complex issues quickly to better help their patients, employees, and others affected by alcohol and drug abuse. Alcohol, Drugs, Genes and the Clinical Laboratory covers the important aspects of drugs and alcohol abuse including genetic aspects along with laboratory methods for analysis of alcohol and abused drugs with emphasis on false positive test results. The book is helpful to healthcare professionals, such as pathologists who oversee alcohol and drug testing, emergency room physicians, family practice physicians who are first healthcare professionals who identify patients susceptible to drug and alcohol abuse, and psychiatrists involved with drug and alcohol rehabilitation programs. It will also be useful to safety professionals who have to assess individuals for workplace responsibilities, ranging from police and recruitment to occupational safety and occupational medicine and public health officials.
(source: Nielsen Book Data)9780128054550 20170313
1 online resource.
  • Cover ; Title page; Copyright page; Contents; List of Contributors; Preface; Acknowledgments; Chapter 1
  • Historical Perspective; Introduction; The discovery of alpha-1-antitrypsin deficiency (AATD); AATD and association with pulmonary emphysema; AATD and association with liver disease; Other disease associations; References; Further Reading; Chapter 2
  • The Swedish Alpha-1-Antitrypsin Screening Study: What We Have Learnt From Birth to Adult Life; Introduction; Fetal life; The liver; Infancy and Childhood; Adolescence and Young Adulthood; The Lungs; Smoking; Adaptive Biochemical Changes
  • Psychological Effects of the Neonatal Alpha-1-Antitrypsin ScreeningFinal Speculation; References; Chapter 3
  • Alpha-1-Antitrypsin Gene Regulation; Introduction; AAT, acute-phase, and tissue expression; The Serpin cluster on 14q31-31.2, the AAT gene, and transcripts; AAT hepatocyte promoter and enhancers; Control of AAT expression in nonhepatic tissue; AAT locus control region and interaction with transcription factors; References; Chapter 4
  • Alpha-1-Antitrypsin Variants; Introduction; Alpha-1-antitrypsin nomenclature and isoelectric focusing; Noncoding DNA variants; References
  • Further ReadingChapter 5
  • Alpha1-Antitrypsin: Structure and Dynamics in Health, Disease and Drug Development; Introduction; Why Understanding the Conformational Behavior of Alpha1-Antitrypsin Matters in Alpha1-Antitrypsin Deficiency; Conformational states associated with function and dysfunction; The Native Conformation; Complexed With Protease as a Consequence of the Functional Mechanism; How Structure Determines Function; The Cleaved Conformation; Finding of Polymers in Disease; Importance of dynamics; Dynamics of Native Wild-Type Alpha1-Antitrypsin in Solution
  • Alpha1-Antitrypsin Folding: How Does It Go Right, How Does It Go Wrong?How Does Alpha1-Antitrypsin Avoid Folding to the Inactive Latent Conformation?; Intracellular Misfolding and Polymerization of Alpha1-Antitrypsin; In vitro studies of Alpha1-Antitrypsin polymerization: lessons and limitations; Different Alpha1-Antitrypsin Polymers Form in Different Experimental Conditions; Studies of M*: the Polymerogenic Intermediate State; Disulfide Locking of Intracellular Polymers; Other Polymeric Architectures Observed In Vitro; Translation; Relating Deficiency Mutations to Disease Phenotype
  • Translating to New Therapeutic Strategies: Stabilizing Alpha1-Antitrypsin Against Pathological Conformational ChangeS4A Blockade; Allosteric stabilization; Polymerization Blockade by a Monoclonal Antibody; Blockade of Disease-Associated Dynamics; Studying polymerization in cells, organisms, and clinical samples; Conclusions; References; Chapter 6
  • Novel Biological Functions of A1AT; Introduction; A1AT is a broad-spectrum inhibitor of proteases; A1AT as an antiinflammatory and immunomodulatory protein; Modified molecular forms of A1AT and their biological functions; S-Nitrosylated A1AT
xliv, 188, 398 pages ; 24 cm
  • [English section]. The Aura and the Chi
  • Hands-on healing
  • Acupuncture
  • Kinesiology
  • Dowsing
  • Homeopathy and flower essences
  • Gem therapy
  • Geobiology and Feng shui
  • Hypnotherapy
  • Yoga
  • Shamanic healing.
  • [Hebrew section]. Biʼure sugyot
  • Haśagot ̣al haḳdamat ha-sefer Ohole Yaʻaḳov [Monsi, 5777]
  • Teshuvot u-mikhtavim.
SAL3 (off-campus storage)

36. Stroke [2004]

1 streaming video file (58 min.) : digital, sound, color
Shortly after his marriage to filmmaker Katarina Peters, 33-year-old cellist, Boris Baberkoff suffered a stroke during the couples' wedding trip to New York City. This autobiographical film documents their journey through pain, crisis, guilt, and rehabilitation to recovery.
171 pages ; 22 cm.
  • L'hôtel-Dieu -- L'huile de petits chiens -- Le balafré -- La ligature des vaisseaux -- Prisonnier -- Le tournoi fatal -- Le grand tour -- La polémique -- La peste -- La Saint-Barthélemy -- Epilogue -- Bibliographie.
"Né vers 1510 et mort en 1590, Ambroise Paré a traversé la quasi-totalité de ce XVIe siècle, haut en couleur et en furie, agité par les guerres extérieures entre le royaume de France et le Saint-Empire romain germanique, comme à l'intérieur par les guerres de religion. Simple barbier ne sachant pas le latin, devenu chirurgien du roi par le seul privilège de sa compétence, il a servi dans les armées de François 1er, de son fils Henri II, puis successivement des trois fils que celui-ci avait eus de Catherine de Médicis, François II, Charles IX et Henri III et il leur a survécu. Chirurgien de guerre, il a participé aux grandes batailles et aux sièges qui ont émaillé ce siècle. Il a senti le vent du boulet, il a vécu les horreurs de la guerre, il a franchi les lignes ennemies et il a été fait prisonnier. Il a opéré des milliers de soldats et de capitaines, des grands du royaume de France et d'ailleurs, et les rois eux-mêmes. Il a survécu à une morsure de vipère, à la peste, à la jalousie et au poison, comme au massacre de la Saint-Barthélemy. Ce livre relate les épisodes les plus épiques de sa vie aventureuse dans leur contexte historique."--Page 4 of cover.
Green Library
406 pages ; 25 cm
  • Complaint: Unaffordable healthcare
  • The age of insurance
  • The age of hospitals
  • The age of physicians
  • The age of pharmaceuticals
  • The age of medical devices
  • The age of testing and ancillary services
  • The age of contractors: Billing, coding, collections, and new medical businesses
  • The age of research and good works for profit: The perversion of a noble enterprise
  • The age of conglomerates
  • The age of healthcare as pure business
  • The age of the Affordable Care Act (ACA)
  • The high price of patient complacency
  • Doctors' bills
  • Hospital bills
  • Insurance costs
  • Drug and medical device costs
  • Bills for tests and ancillary services
  • Better healthcare in a digital age
  • Appendix A: Pricing/shopping tools
  • Appendix B: Tools for vetting hospitals
  • Appendix C: Glossary for medical bills and explanations of benefits
  • Appendix D: Tools to help you figure out whether a test or a procedure is really necessary
  • Appendix E: Templates for protest letters.
"An award-winning New York Times reporter Dr. Elisabeth Rosenthal reveals the dangerous, expensive, and dysfunctional American healthcare system, and tells us exactly what we can do to solve its myriad of problems. It is well documented that our healthcare system has grave problems, but how, in only a matter of decades, did things get this bad? Dr. Elisabeth Rosenthal doesn't just explain the symptoms; she diagnoses and treats the disease itself. Rosenthal spells out in clear and practical terms exactly how to decode medical doublespeak, avoid the pitfalls of the pharmaceuticals racket, and get the care you and your family deserve. She takes you inside the doctor-patient relationship, explaining step by step the workings of a profession sorely lacking transparency. This is about what we can do, as individual patients, both to navigate a byzantine system and also to demand far-reaching reform. Breaking down the monolithic business into its individual industries--the hospitals, doctors, insurance companies, drug manufacturers--that together constitute our healthcare system, Rosenthal tells the story of the history of American medicine as never before. The situation is far worse than we think, and it has become like that much more recently than we realize. Hospitals, which are managed by business executives, behave like predatory lenders, hounding patients and seizing their homes. Research charities are in bed with big pharmaceutical companies, which surreptitiously profit from the donations made by working people. Americans are dying from routine medical conditions when affordable and straightforward solutions exist. Dr. Rosenthal explains for the first time how various social and financial incentives have encouraged a disastrous and immoral system to spring uporganicallyin a shockingly short span of time. The system is in tatters, but we can fight back. An American Sicknessis the frontline defense against a healthcare system that no longer has our well-being at heart"-- Provided by publisher.
Medical Library (Lane)
230 pages : illustrations ; 23 cm
Green Library
1 online resource (102 pages)
  • Front Cover ; Analysis for Time-to-Event Data under Censoring and Truncation; Copyright; Contents; Chapter 1 Introduction ; 1.1 Introduction to the book; 1.2 Examples; 1.3 Brief review of survival analysis under truncation; 1.4 Preliminaries; Chapter 2 Survival analysis for univariate truncated data ; 2.1 Introduction; 2.2 Nonparametric estimation; 2.3 Linear Rank Statistics for umbrella alternative hypothesis; 2.4 Regression analysis for truncated and censored data; Chapter 3 Bivariate estimation with truncated survival data ; 3.1 Introduction; 3.2 Bivariate distributions.
  • 3.3 Types of bivariate truncated survival data3.4 The inverse probability weighted estimator with only one censoring variable; 3.5 The transformation estimator; 3.6 Example; 3.7 Discussion; Chapter 4 Accelerated failure time model for truncated and censored survival data ; 4.1 Introduction; 4.2 WLS estimator for univariate LTRC data under AFT model ; 4.3 AFT model for bivariate survival data under truncation and censoring; Chapter 5 Recent advances for truncated survival data ; 5.1 Linear transformation models; 5.2 Joint modelling of survival events and longitudinal data under random truncationBibliography; Index; Back Cover.