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1 online resource : illustrations (chiefly color)
  • Section 1 Structural and Molecular Bases of Ion Channel Function 1. Voltage-Gated Sodium Channels and Electrical Excitability of the Heart 2. Voltage-Gated Calcium 3. Voltage-Gated Potassium Channels 4. Structural and Molecular Bases of Cardiac Inward Rectifier Potassium Channel Function 5. Mammalian Calcium Pumps in Health and Disease 6. Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function 7. Organellar Ion Channels and Transporters 8. Molecular Organization, Gating and Function of Connexin-based Gap Junction Channels and Hemichannels Section 2 Biophysics of Cardiac Ion Channel Function 9. Structure-function relations of Heterotrimetric complexes of sodium channel a and � subunits 10. Regulation of Cardiac Calcium Channels 11. Inhibition of Phosphoinositide 3-Kinase and Acquired Long QT Syndrome 12. Structural Determinants and Biophysical Properties of hERG1 Channel Gating 13. Molecular Regulation of Cardiac Inward Rectifier Potassium Channels by Pharmacological Agents 14. Cardiac Stretch-Activated Channels and Mechano-Electric Coupling 15. Biophysical Properties of Gap Junctions 16. Excitation-Contraction Coupling Section 3 Intermolecular Interactions and Cardiomyocyte Electrical Function 17. Ion Channel Trafficking in the Heart 18. Microdomain Interactions of Macromolecular Complexes and Regulation of the Sodium Channel Nav1.5 19. Fibroblast growth factor homologous factors modulate cardiac calcium channels. 20. Macromolecular Complexes and Cardiac Potassium Channels 21. Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias 22. The intercalated disc: A molecular network that integrates electrical coupling, intercellular adhesion and cell excitability 23. Function and dysfunction of ion channel membrane trafficking and post translational modification 24. Feedback Mechanisms for Cardiac-Specific microRNAs and cAMP Signaling in Electrical Remodeling. Section 4 Cell Biology of Cardiac Impulse Initiation and Propagation 25. Stem cell-derived nodal-like cardiomyocytes as a novel pharmacologic tool: insights from sinoatrial node development and function. 26. Gene Therapy and Biological Pacing 27. Intercellular Communication and Impulse Propagation 28. Mechanisms of normal and dysfunctional Sinoatrial Nodal Excitability and Propagation 29. Cell Biology of the Specialized Cardiac Conduction System 30. Cardiac Remodeling and Regeneration Section 5 Models of Cardiac Excitation 31. Ionic Mechanisms of Atrial Action Potentials 32. Genetic algorithms to generate dynamical complexity electrophysiological models 33. Calcium Signaling in Cardiomyocyte Models with Realistic Geometries 34. Theory of Rotors and Arrhythmias 35. Computational approaches for Accurate Rotor localization in the Human Atria 36. Modeling the aging heart Section 6 Neural Control of Cardiac Electrical Activity 37. Innervation of the sinoatrial node 38. Mechanism for altered autonomic and oxidant regulation of cardiac sodium currents. 39. Pulmonary Vein Ganglia and the Neural Regulation of the Heart Rate 40. Neural Activity and Atrial Tachyarrhythmias 41. Sympathetic Innervation and Cardiac Arrhythmias Section 7 Arrhythmia Mechanisms 42. The Molecular Pathophysiology of Atrial Fibrillation 43. Myofibroblasts, Cytokines, and Persistent Atrial Fibrillation 44. Role of the Autonomic Nervous System in Atrial Fibrillation 45. Rotors in Human Atrial Fibrillation 46. Body surface frequency-phase mapping of atrial fibrillation. 47. Panoramic Mapping of Atrial Fibrillation from the body surface 48. Mechanisms of Human Ventricular Tachycardia and Human Ventricular Fibrillation 49. Genetics of Atrial Fibrillation Section 8 Molecular Genetics and Pharmacogenomics 50. Mechanisms in Heritable Sodium Channel Diseases 51. Genetic, Ionic and Cellular Mechanisms Underlying the J Wave Syndromes 52. Inheritable Potassium Channel Diseases 53. Inheritable Phenotypes Associated With Altered Intracellular Calcium Regulation Section 9 Pharmacologic, Genetic and Cell Therapy of Ion Channel Dysfunction 54. Pharmacologic Bases of Antiarrhythmic Therapy 55. Pharmacogenomics of Cardiac Arrhythmias 56. Gene therapy to treat cardiac arrhythmias 57. Highly Mature Human iPSC-Derived Cardiomyocytes as Models for Cardiac Electrophysiology and Drug Testing 58. Cardiac repair with human induced pluripotent stem cell-derived cardiovascular cells. Section 10 DIAGNOSTIC EVALUATION 59. Assessment of the patient with a cardiac arrhythmia 60. Electrocardiography of tachyarrhythmias: Differential diagnosis of narrow and wide QRS complex tachycardias 61. Electroanatomic Mapping for arrhythmias 62. Computed tomography for electrophysiology 63. Magnetic resonance imaging for electrophysiology 64. Intracardiac echocardiography for electrophysiology 65. Exercise-induced arrhythmias 66. Cardiac monitoring: short- and long-term recording 67. Head-up Tilt Table Testing 68. Autonomic Regulation and Cardiac Risk 69. T-wave alternans 70. Noninvasive Electrocardiographic Imaging of Human Ventricular Arrhythmias and Electrophysiological Substrate 71. Genetic testing Section 11 SUPRAVENTRICULAR TACHYARRHYTHIAS: MECHANISMS, CLINICAL FEATURES, AND MANAGEMENT 72. Sinus node abnormalities 73. Atrial tachycardia 74. Atrial tachycardia in adults with congenital heart disease 75. Typical and Atypical Atrial Flutter: Mapping and Ablation 76. Atrial fibrillation 77. Preexcitation, Atrioventricular reentry, Variants 78. Electrophysiological Characteristics of Atrioventricular Nodal Reentrant Tachycardia: Implications for the Rentrant Circuits 79. Junctional tachycardia Section 12 VENTRICULAR TACHYCARRHYTHMIAS: MECHANISMS, CLNICAL FEATURES, AND MANAGEMENT 80. Premature ventricular complexes 81. Outflow tract ventricular tachycardias: Mechanisms, Clinical Features, and Management 82. Fascicular ventricular arrhythmias 83. Bundle branch reentry tachycardia 84. Ischemic heart disease 85. Ventricular Tachycardia in Patients with Dilated Cardiomyopathy 86. Ventricular Arrhythmias in Hypertrophic Cardiomyopathy 87. Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy 88. VTs in Catcholaminergic Cardiomyopathy (Catecholaminergic polymorphic ventricular tachycardia) 89. Ventricular Arrhythmias in Heart failure 90. Arrhythmias and conduction disturbances in Non Compaction Cardiomyopathy 91. Takotsubo cardiomyopathy 92. Brugada syndrome 93. Long and short QT syndromes 94. Anderson-Tawil syndrome 95. Timothy syndrome 96. J Wave Syndromes 97. Idiopathic ventricular fibrillation 98. Sudden infant death syndrome 99. Sudden cardiac arrest/death in adults 100. Neurologic disorders 101. Drug-Induced Ventricular Tachycardia 102. Ventricular Arrhythmias in Congenital Heart Disease Section 13 SYNCOPE and Bradyarrhythmias 103. Syncope 104. Postural orthostatic tachycardia syndrome 105. Progressive conduction system disease 106. Atrioventricular block Section 14 ARRHYTHMIAS IN SPECIAL POPULATIONS PHARMACOLOGIC THERAPY 107. Sex differences in arrhythmias 108. Sudden cardiac death in athletes, inlcuding commotio cordis 109. Pediatric populations 110. Sleep-disordered breathing and arrhythmias 111. Ventricular Assist devices and Cardiac Transplantation Recipients Section 15 PHARMACOLOGIC THERAPY 112. Standard antiarrhythmic drugs 113. Innovations In Antiarrhythmic Drug Therapy 114. Nontraditional drugs for sudden cardiac death 115. Prevention of stroke in atrial fibrillation: warfarin, anti-factor Xa and thrombin drugs Section 16 CARDIAC IMPLANTABLE ELECTRONIC DEVICES 116. Implantable cardioverter defibrillators: technical aspects 117. Implantable cardioverter defibrillators: clinical aspects 118. Subcutaneous implantable defibrillator 119. Implantable pacemakers 120. Cardiac resynchronization therapy 121. Newer applications of pacemakers 122. Remote monitoring Section 17 CATHETER ABLATION 123. Catheter Ablation: Technical aspects 124. Catheter Ablation: Clinical aspects 125. Ablation for Atrial fibrillation 126. Ablation of Supraventricular tachycardias 127. Catheter Abliation for Ventricular tachycardias with/without structural heart disease 128. Epicardial and other approaches 129. Ventricular fibrillation 130. Ablation in Pediatrics 131. Congenital heart disease 132. Anesthesiology for EP procedures Section 18: SURGERY FOR ARRHYTHMIAS 133. Surgery for Atrial fibrillation and other supraventricular tachycardias 134. Surgery for Ventricular tachycardia Section 19 NEW APPROACHES 135. Cervical vagal stimulation for heart failure 136. Baroreflex stimulation 137. Spinal cord stimulation for heart failure and Arrhythmias 138. Renal artery denervation 139. Left atrial appendage occlusion/ligation.
  • (source: Nielsen Book Data)9780323447331 20170814
Rapid advancements in cardiac electrophysiology require today's health care scientists and practitioners to stay up to date with new information both at the bench and at the bedside. The fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs. Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need, including the underlying basic science and the latest clinical advances in the field.
(source: Nielsen Book Data)9780323447331 20170814
1 online resource (356 p.) : ill. (some col.)
"Cardioprotective Natural Products: Promises and Hopes focuses on the recent advances in the research of bioactive natural products with cardioprotective potential against various cardiovascular diseases/disorders. The aim of this book is to underline the promise and future hope in bioactive natural molecules, herbal formulations, natural dietary supplements and related materials in the prevention and cure of cardiovascular diseases in a scientific way. This book, which comprises a variety of about 9 chapters written by active researchers and leading experts, brings together an overview of current discoveries and trends in this field. This volume is also an outstanding source of information with regard to the industrial application of natural products for medicinal purposes. The broad interdisciplinary approach adopted in this book ensures that it is much more interesting to scientists deeply engaged in the research and/or use of bioactive natural products. It will serve not only as a valuable resource for researchers in their own fields to predict promising leads for developing pharmaceuticals to prevent and treat disease manifestations, but will hopefully also motivate young scientists to engage in the dynamic field of natural products research."--Publisher's website.
1 online resource
Keeping up with the use of new technologies in cardiology is becoming increasingly challenging. Case Studies in Clinical Cardiac Electrophysiology helps to bridge the gap between knowledge and application with 28 cases spanning both common and uncommon arrhythmias and ablation scenarios, each of which includes the clinical presentation, baseline ECG, ECG during arrhythmia, stepwise electrophysiologic diagnostic maneuvers and some of their pitfalls, and optimal therapy. Online access to the complete contents ensures the information you need is right at your fingertips.
1 online resource (xii, 256 pages) : illustrations (some color).
  • PrefaceTable of Contents...Contributing Authors...Part I Introduction1. Evaluating Nanomedicines: Obstacles and AdvancementsMagdalena Swierczewska, Rachael M. Crist, and Scott E. McNeilPart II Sterility and Endotoxin Testing2. Detection of Bacterial Contamination in Nanoparticle Formulations by Agar Plate TestTimothy M. Potter, Barry W. Neun, Anna N. Ilinskaya, and Marina A. Dobrovolskaia3. Considerations and Some Practical Solutions to Overcome Nanoparticle Interference with LAL Assays and to Avoid Endotoxin Contamination in NanoformulationsBarry W. Neun and Marina A. DobrovolskaiaPart III Physicochemical Characterization4. Elemental Analysis in Biological Matrices Using ICP-MSMatthew N. Hansen and Jeffrey D. Clogston5. PEG Quantitation Using Reversed Phase High Performance Liquid Chromatography and Charged Aerosol DetectionMackensie C. Smith and Jeffrey D. Clogston6. Quantitation of Surface Coating on Nanoparticles Using Thermogravimetric AnalysisAlpana A. Dongargaonkar and Jeffrey D. Clogston7. Immunoelectron Microscopy for Visualization of NanoparticlesSarah R. Anderson, David Parmiter, Ulrich Baxa, and Kunio Nagashima 8. Imaging of Liposomes by Transmission Electron MicroscopyUlrich BaxaPart IV Immunology9. Updated Method for In Vitro Analysis of Nanoparticle Hemolytic PropertiesBarry W. Neun, Anna N. Ilinskaya, and Marina A. Dobrovolskaia10. In Vitro Assessment of Nanoparticle Effects on Blood CoagulationTimothy M. Potter, Jamie C. Rodriguez, Barry W. Neun, Anna N. Ilinskaya, Edward Cedrone, and Marina A. Dobrovolskaia11. In Vitro Analysis of Nanoparticle Effects on the Zymosan Uptake by Phagocytic CellsTimothy M. Potter, Sarah L. Skoczen, Jamie C. Rodriguez, Barry W. Neun, Anna N. Ilinskaya, Edward Cedrone, and Marina A. Dobrovolskaia12. Assessing NLRP3 Inflammasome Activation by NanoparticlesBhawna Sharma, Christopher B. McLeland, Timothy M. Potter, Stephan T. Stern, and Pavan P. Adiseshaiah13. Analysis of Complement Activation by NanoparticlesBarry W. Neun, Anna A. Ilinskaya, and Marina A. Dobrovolskaia 14. Methods for Analysis of Nanoparticle Immunosuppressive Properties In Vitro and In VivoTimothy M. Potter, Barry W. Neun, and Marina A. Dobrovolskaia15. Analysis of Pro-Inflammatory Cytokine and Type II Interferon Induction by NanoparticlesTimothy M. Potter, Barry W. Neun, Jamie C. Rodriguez, Anna N. Ilinskaya, and Marina A. Dobrovolskaia 16. Analysis of Nanoparticle Adjuvant Properties In VivoBarry W. Neun and Marina A. Dobrovolskaia17. In Vitro and In Vivo Methods for Analysis of Nanoparticle Potential to Induce Delayed Type Hypersensitivity ReactionsTimothy M. Potter, Barry W. Neun, and Marina A. Dobrovolskaia18. Autophagy Monitoring Assay II: Imaging Autophagy Induction in LLC-PK1 Cells Using GFP-LC3 Protein Fusion ConstructPavan P. Adiseshaiah, Sarah L. Skoczen, Jamie C. Rodriguez, Timothy M. Potter, Krishna Kota, and Stephan T. SternPart V Drug Release and In Vivo Efficacy19. Improved Ultrafiltration Method to Measure Drug Release from Nanomedicines Utilizing a Stable Isotope TracerSarah L. Skoczen and Stephan T. Stern20. Designing an In Vivo Efficacy Study of Nanomedicines for Preclinical Tumor Growth InhibitionPavan P. Adiseshaiah and Stephan T. Stern.
  • (source: Nielsen Book Data)9781493973507 20171211
This second edition volume expands on the first edition by providing up-to-date protocols to characterize nanomaterials used as drug delivery agents. The chapters in this book are divided into 5 parts and cover topics such as: advances and obstacles in nanomedicine research; methods to test sterility and endotoxin, physicochemical features, immunological effects, drug release, and in vivo efficacy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Characterization of Nanoparticles Intended for Drug Delivery, Second Edition is a valuable tool for researchers and pharmaceutical and biotechnology developers who are evaluating the clinical potential of nanomedicines in preclinical studies.>.
(source: Nielsen Book Data)9781493973507 20171211
1 streaming video file (82 min.) : digital, sound, color
This film argues that the link between cholesterol and heart disease is tenuous and that its persistence results from a potent mix of bad science, entrenched interests, and pharmaceutical profits.
1 online resource (xix, 463 pages) : color illustrations.
1 online resource (xxii, 487 pages) : illustrations (some color)
  • Epidemiology of chronic coronary artery disease
  • The global perspective of ischemic heart disease
  • Genetics of coronary atherosclerosis
  • Basic mechanisms of atherosclerosis
  • Coronary microvascular dysfunction
  • Precipitants of myocardial ischemia
  • History and physical examination
  • Lipid measurements
  • Standard and novel biomarkers
  • ECG and standard exercise stress testing
  • Echocardiography
  • Nuclear imaging and pet
  • CT and MRI
  • Invasive testing
  • Putting it all together : which test for which patient?
  • Goals of therapy
  • Global risk assessment
  • Lifestyle interventions
  • Obesity and the obesity paradox
  • The medical treatment of stable angina
  • Antiplatelet and anticoagulant drugs
  • Prevention of sudden cardiac death
  • Revascularization approaches
  • Managing chronic coronary artery disease in patients with diabetes
  • Angina in patients with evidence of myocardial ischemia and no obstructive coronary artery disease
  • Depression, anxiety, and stress
  • Refractory angina
  • Primary prevention of atherosclerotic cardiovascular disease
  • Screening for atherosclerotic cardiovascular disease in asymptomatic individuals
  • Secondary prevention of coronary artery disease.
Featuring expert guidance from Drs. James de Lemos and Torbjorn Omland, as well as other globally known leaders in cardiology, Chronic Coronary Artery Disease covers every aspect of managing and treating patients suffering from chronic coronary syndromes. This brand-new companion to Braunwald's Heart Disease was designed as a stand-alone reference for physicians treating patients who present with complex, unique challenges, offering the latest information on the use of imaging modalities in diagnosis and treatment, advances in interventional and surgical approaches to revascularization, new medications to improve symptoms and outcomes in chronic CAD, and much more. Relevant updates to the text are sourced regularly from the parent reference, Braunwald's Heart Disease and delivered on Expert Consult at no additional cost. These updates cover late-breaking clinical trials, reviews of important new articles, and the latest guidance on clinical practice, all selected and masterfully edited by Dr. Eugene Braunwald.
xi, 239 pages : illustrations (some color) ; 22 cm
  • 1. Introduction: the West, Spain and the early circulation of penicillin.- 2. Fleming in Spain: the hero, the antimicrobial and the politics of public acclaim.- 3. Manufacturing penicillin: health, industry and gender.- 4. Smuggling: The management of scarcity and trade of penicillin as a post-war commodity.- 5. Modern Times: screening antibiotics and the factory line.- 6. A new promising drug: bacteria, antibiotics and marketing.- 7. Beyond healing: antibiotic resistance and regulatory regimes as agents in the Spanish transition to democracy.- 8. Penicillin in Spain, 1940s-1980s: Circulating health, research and gender.- 9. Final reflections.
  • (source: Nielsen Book Data)9783319697178 20180219
This book reconstructs the early circulation of penicillin in Spain, a country exhausted by civil war (1936-1939), and oppressed by Franco's dictatorship. Embedded in the post-war recovery, penicillin's voyages through time and across geographies - professional, political and social - were both material and symbolic. This powerful antimicrobial captivated the imagination of the general public, medical practice, science and industry, creating high expectations among patients, who at times experienced little or no effect. Penicillin's lack of efficacy against some microbes fueled the search for new wonder drugs and sustained a decades-long research agenda built on the post-war concept of development through scientific and technological achievements. This historical reconstruction of the social life of penicillin between the 1940s and 1980s - through the dictatorship to democratic transition - explores political, public, medical, experimental and gender issues, and the rise of antibiotic resistance.
(source: Nielsen Book Data)9783319697178 20180219
Green Library
xxxii, 158 pages : illustrations ; 24 cm
  • Acknowledgements Personal Prologue Introduction: Placing Morita in the History of Psychological Medicine 1. Classic Morita Therapy: Inside and Outside Japan 2. Morita, Japonisme, Karen Horney and Zen 3. Morita and Consciousness 4. Existential Reflexions in Morita Therapy 5. Treating Cruelty-based Trauma in an Ecological Context Epilogue Glossary of Terms References.
  • (source: Nielsen Book Data)9780415790512 20180312
Shoma (Masatake) Morita, M.D. (1874-1938) was a Japanese psychiatrist-professor who developed a unique four stage therapy process. He challenged psychoanalysts who sanctioned an unconscious or unconsciousness (collective or otherwise) that resides inside the mind. Significantly, he advanced a phenomenal connection between existentialism, Zen, Nature and the therapeutic role of serendipity. Morita is a forerunner of eco-psychology and he equalised the strength between human-to-human attachment and human-to-Nature bonds. This book chronicles Morita's theory of "peripheral consciousness", his paradoxical method, his design of a natural therapeutic setting, and his progressive-four stage therapy. It explores how this therapy can be beneficial for clients outside of Japan using, for the first time, non-Japanese case studies. The author's personal material about training in Japan and subsequent practice of Morita's ecological and phenomenological therapy in Australia and the United States enhance this book. LeVine's coining of "cruelty-based trauma" generates a rich discussion on the need for therapy inclusive of ecological settings. As a medical anthropologist, clinical psychologist and genocide scholar, LeVine shows how the four progressive stages are essential to the classic method and the key importance of the first "rest" stage in outcomes for clients who have been embossed by trauma. Since cognitive science took hold in the 1970s, complex consciousness theories have lost footing in psychology and medical science. This book reinstates "consciousness" as the dynamic core of Morita therapy. The case material illustrates the use of Morita therapy for clients struggling with the aftermath of trauma and how to live creatively and responsively inside the uncertainty of existence. The never before published archival biographic notes and photos of psychoanalyst Karen Horney, Fritz Perls, Eric Fromm and other renowned scholars who took an interest in Morita in the 1950s and 60s provide a dense historical backdrop.
(source: Nielsen Book Data)9780415790512 20180312
SAL3 (off-campus storage)
1 online resource. Digital: text file; PDF.
  • Chapter 1. Introduction and Biogeography (Jessica Halofsky, David Peterson, and Karen Dante-Wood).- Chapter 2. Climatology (Linda Joyce and Marian Talbert).- Chapter 3. Water Resources (Chales Luce).- Chapter 4. Fisheries (Michael Young and Daniel Isaak). - Chapter 5. Forest Vegetation (Robert Keane).- Chapter 6.- Non-Forest Vegetation (Matthew Reeves).- Chapter 7. Ecological Disturbance (Rachel Loehman).- Chapter 8. - Wildlife (Kevin McKelvey and Polly Buotte).- Chapter 9. Recreation (Michael Hand and Megan Lawson).- Chapter 10.- Ecosystem Services (Travis Warziniack).- Chapter 11. Cultural Resources (Carl Davis).- Chapter 12. Applications in Resource Management and Planning (Karen Dante-Wood and Linh Hoang).
  • (source: Nielsen Book Data)9783319569277 20171127
This book is the result of a team of approximately 100 scientists and resource managers who worked together for two years to understand the effects of climatic variability and change on water resources, fisheries, forest vegetation, non-forest vegetation, wildlife, recreation, cultural resources and ecosystem services. Adaptation options, both strategic and tactical, were developed for each resource area. This information is now being applied in the northern rocky Mountains to ensure long-term sustainability in resource conditions.The volume chapters provide a technical assessment of the effects of climatic variability and change on natural and cultural resources, based on best available science, including new analyses obtained through modeling and synthesis of existing data. Each chapter also contains a summary of adaptation strategies (general) and tactics (on-the-ground actions) that have been developed by science-management teams.
(source: Nielsen Book Data)9783319569277 20171127
1 online resource (xi, 631 pages) : illustrations (chiefly color)
  • Preinvasive disease of the cervix / L. Stewart Massad
  • Preinvasive disease of the vagina and vulva and related disorders / Cara A. Mathews and Joan L. Walker
  • Invasive cervical cancer / Krishnansu S. Tewari and Bradley J. Monk
  • Endometrial hyperplasia, estrogen therapy, and the prevention of endometrial cancer / Lisa M. Landrum, Rosemary E. Zuna, and Joan L. Walker
  • Adenocarcinoma of the uterine corpus / William T. Creasman and David Scott Miller
  • Sarcoma of the uterus / D. Scott McMeekin and William T. Creasman
  • Gestational trophoblastic disease / Emma L. Barber and John T. Soper
  • Invasive cancer of the vulva / Thomas Herzog
  • Invasive cancer of the vagina / Marilyn Huang, Brian M. Slomovitz, and Robert L. Coleman
  • The adnexal mass / Camille C. Gunderson, Robert S. Mannel, and Philip J. Di Saia
  • Epithelial ovarian cancer / Eric L. Eisenhauer, Ritu Salani, and Larry J. Copeland
  • Germ cell, stromal, and other ovarian tumors / Emily R. Penick, Chad Hamilton, G. Larry Maxwell, and Charlotte S. Marcus
  • Fallopian tube cancer / Erica R. Hope, G. Larry Maxwell, and Chad A. Hamilton
  • Breast diseases / Patricia A. Cronin and Mary L. Gemignani
  • Cancer in pregnancy / Krishnansu S. Tewari
  • Complications of disease and therapy / Kemi M. Doll, Daniel L. Clarke-Pearson
  • Basic principles of chemotherapy / Christina S. Chu and Stephen C. Rubin
  • Targeted therapy and molecular genetics / Shannon N. Westin, Anil K. Sood, and Robert L. Coleman
  • Genes and cancer : genetic counseling and clinical management / David G. Mutch, Sheri Babb, and Philip J. Di Saia
  • Palliative care and quality of life / Dana M Chase, Siu-Fun Wong, Lari Wenzel, and Bradley J. Monk
  • Role of minimally invasive surgery in gynecologic malignancies / Floor J. Backes, David E. Cohn, Robert S. Mannel, and Jeffrey M. Fowler
  • Epidemiology of commonly used statistical terms and analysis of clinical studies / Wendy R. Brewster
  • Basic principles in gynecologic radiotherapy / Catheryn M. Yashar
  • Appendices. Staging: staging of cancer at gynecologic sites
  • Modified from common terminology criteria for adverse events (common terminology criteria for adverse events)
  • Blood component therapy
  • Suggested recommendations for routine cancer screening
  • Nutritional therapy.
The most readable, most comprehensive book in its field, Clinical Gynecologic Oncology, 9th Edition is the leading reference for diagnosis and treatment of gynecologic cancers - a must-have reference for improving outcomes and providing effective care. A "who's who" list of contributing authors, under the editorial direction of Drs. Philip DiSaia and William Creasman, provides expert guidance on clinical presentations and management, now fully up to date with a brand-new design for faster, easier reference.
(source: Nielsen Book Data)9780323400671 20170410
1 online resource (535 p.) : ill. (some col.).
"Clinical research monitoring is a vital aspect of Good Clinical Practice (GCP). Its principles are straightforward: they are aimed at protecting those subjects that participate in the trial, and their goal is to provide reliable data that will contribute to the safety and efficacy of the intervention under study, i.e. to support the health of future subjects. However, the practical implementation of these major goals is complicated. Various mishaps have happened in recent history, and an extensive set of international rules and regulations have emerged. This book gives a thorough survey of the ethical and legal aspects of clinical research and provides a detailed guideline for implementing these aspects into the practice of studying investigational medicinal products in humans, in the European context. It can be used as a study aid for starting monitors, a reference guide for more experienced monitors, and anyone else involved in clinical research."--Publisher's website.
1 online resource
The Clinician's Guide to Cognitive-Behavioral Therapy for Childhood Obsessive-Compulsive Disorder brings together a wealth of experts on pediatric and adolescent OCD, providing novel cognitive behavioral strategies and considerations that therapists can immediately put into practice. The book provides case studies and example metaphors on how to explain exposure models to children in a developmentally appropriate manner. The book also instructs clinicians on how to use symptom information and rating scales to develop an appropriate exposure hierarchy. The book is arranged into two major sections: assessment and treatment of childhood OCD and special considerations in treating childhood OCD. Each chapter is structured to include relevant background and empirical support for the topic at hand, practical discussion of the nature and implementation of the core component (such as exposure and response prevention, cognitive therapy, psychoeducation and more), and a case illustration that highlights the use of a particular technique.
268 pages, xvi pages of plates : illustrations (chiefly color) ; 22 cm
  • Préface, Pierre Échinard -- Le médecin histoire d'une vie -- De Grenoble à Marseille -- Les premières années -- Une carrière fulgurante -- Les années noires -- L'aventure égyptienne -- Premières mesures d'urgence -- Abou-Zabel, centre hospitalier et universitaire -- L'hôpital d'Abou-Zabel -- Les ambulances de campagne -- L'École de Médecine d'Abou-Zabel -- Installation des autres Écoles à Abou-Zabel -- Le service de santé de la marine -- La médecine civile -- La vaccination antivariolique -- L'épidémie de choléra de 1831 -- La peste de 1834-1835 -- Le service de santé dans les provinces -- Médecins et charlatans -- Les maladies vénériennes -- Le second souffle -- Premier voyage en Europe -- Transfert de l'hôpital et de l'école de médecine au Caire -- Ministère et commission de l'instruction publique -- Quelques mois de vacances -- La campagne de Syrie -- Retour au Caire -- Deuxième voyage en Europe -- Les dernières années -- L'après Méhémet-Ali -- La disgrâce et le retour à Marseille (1849-1856) -- Deux ans pour reconstruire (1856-1858) -- Une retraite bien méritée -- Un homme aux multiples facettes -- L'homme -- Rigueur et intransigeance -- Un égo surdimensionné -- Une immense générosité -- Des convictions religieuses à toute épreuve -- Fidèle et reconnaissant -- Un parfait homme du monde -- Francs-maçons et saint-simoniens -- Vous avez dit français ? -- Le proche de Méhemet-Ali -- Un despote éclairé -- La reconstruction -- Le bras de fer -- Clot-Bey et la politique: le porte-parole déguisé -- L'homme de science -- Premières prises de position -- Non contagiosité contre contagiosité du choléra et de la peste -- Et bien d'autres maladies -- La vie affective -- Sa mère -- Sa vie sentimentale -- Généreux, mais proche de ses intérêts -- Le collectionneur -- Le jardin botanique -- Le cabinet d'histoire naturelle -- Le collectionneur d'antiquités égyptiennes -- Une collection de monnaies et médailles -- Les honneurs.
"Né à Grenoble en 1793, Antoine-Barthélemy Clot se rend en 1813 à Marseille pour étudier la médecine. Docteur en médecine en 1820 à Montpellier, il est docteur en chirurgie en 1823. Doté d'une forte personnalité, il a déjà été évincé de ses postes hospitaliers et de la Société académique de médecine de Marseille lorsque, en 1825, il est recruté par Tourneau, un Français au service du pacha d'Égypte Méhémet Ali, en tant que médecin et chirurgien en chef de l'armée de ce dernier. Antoine-Barthélemy Clot s'embarque le 21 janvier 1825. Son contrat, prévu pour cinq ans, se prolongera jusqu'en 1849. Clot a été le maître d'oeuvre de la modernisation des institutions médicales égyptiennes. Il crée un Conseil de santé et un service sanitaire militaire, puis fonde un gigantesque complexe hospitalier à Abou-Zabel, ainsi qu'une École de médecine ; il développe la vaccination antivariolique et fonde une École de sages-femmes. Après l'épidémie de choléra de 1832, son dévouement exemplaire lui vaut d'être fait bey par Méhémet Ali. Clot-Bey avait acquis une importante collection d'antiquités égyptiennes, qu'il a cédée à la ville de Marseille. On peut aujourd'hui en admirer les pièces au musée de la Vieille Charité. Cette biographie, qui se fonde sur une documentation exhaustive, retrace la vie de l'homme et du médecin et dresse un portrait nuancé de ce personnage plein de contrastes, qui a contribué à écrire l'une des pages les plus importantes du développement de l'Égypte moderne."--Page 4 of cover.
Green Library
xvi, 368 pages : illustrations (some color) ; 22 cm.
Green Library
1 online resource (xxi, 300 pages) : color illustrations, charts.
  • Meeting Emerging Challenges and Opportunities in Psychiatry Through Computational Neuroscience Section I. Applying Circuit Modeling to Understand Psychiatric Symptoms 1. Cortical Circuit Models in Psychiatry: Linking Disrupted Excitation-Inhibition Balance to Cognitive Deficits Associated with Schizophrenia 2. Serotonergic Modulation of Cognition in Prefrontal Cortical Circuits in Major Depression 3. Dopaminergic Neurons in the Ventral Tegmental Area and their Dysregulation in Nicotine Addiction Section II. Modeling Neural System Disruptions in Psychiatric Illness 4. Computational Models of Dysconnectivity in Large-Scale Resting-State Networks 5. Dynamic Causal Modelling and its Application to Psychiatric Disorders 6. Systems Level Modeling of Cognitive Control in Psychiatric Disorders: A focus on schizophrenia 7. Computational Psychiatry: Mathematical Modeling of Mental Illness Section III: Characterizing Complex Psychiatric Symptoms via Mathematical Models 8. A Case Study in Computational Psychiatry: Addiction as Failure Modes of the Decision-Making System 9. Modeling Negative Symptoms in Schizophrenia 10. Bayesian Approaches to Learning and Decision Making 11. Computational Phenotypes Revealed by Interactive Economic Games.
  • (source: Nielsen Book Data)9780128098257 20180129
Computational Psychiatry: Mathematical Modeling of Mental Illness is the first systematic effort to bring together leading scholars in the fields of psychiatry and computational neuroscience who have conducted the most impactful research and scholarship in this area. It includes an introduction outlining the challenges and opportunities facing the field of psychiatry that is followed by a detailed treatment of computational methods used in the service of understanding neuropsychiatric symptoms, improving diagnosis and guiding treatments. This book provides a vital resource for the clinical neuroscience community with an in-depth treatment of various computational neuroscience approaches geared towards understanding psychiatric phenomena. Its most valuable feature is a comprehensive survey of work from leaders in this field.
(source: Nielsen Book Data)9780128098257 20180129
1 online resource.
  • Contents Contributing authors Preface Tribute Acknowledgements Part I Introduction 1 History 2 Anterior eye 3 Visual optics Part II Soft contact lenses 4 Soft lens materials 5 Soft lens manufacture 6 Soft lens optics 7 Soft lens measurement 8 Soft lens design and fitting 9 Soft toric lens design and fitting 10 Soft lens care systems Part III Rigid contact lenses 11 Rigid lens materials 12 Rigid lens manufacture 13 Rigid lens optics 14 Rigid lens measurement 15 Rigid lens design and fitting 16 Rigid toric lens design and fitting 17 Rigid lens care systems Part IV Lens replacement modalities 18 Daily disposable soft lenses 19 Reusable soft lenses 20 Planned replacement rigid lenses Part V Special lenses and fitting considerations 21 Scleral lenses 22 Tinted lenses 23 Presbyopia 24 Extended wear 25 Sport 26 Keratoconus 27 High ametropia 28 Babies and children 29 Therapeutic applications 30 Post-refractive surgery 31 Post-keratoplasty 32 Orthokeratology 33 Myopia control 34 Diabetes Part VI Patient examination and management 35 History taking 36 Diagnostic instruments 37 Preliminary examination 38 Patient education 39 Aftercare 40 Complications 41 Digital imaging 42 Compliance 43 Practice management Appendices A Contact lens design and specifications B Contact lens tolerances C Vertex distance correction D Corneal curvature - corneal power conversion E Extended keratometer range conversion F Soft lens average thickness G Soft lens oxygen performance H Constant edge clearance rigid lens designs I Soft toric lens misalignment demonstrator J Dry eye questionnaire K Efron grading scales for contact lens complications L Scleral lens fit scales Index.
  • (source: Nielsen Book Data)9780702066603 20170814
In this thoroughly revised and updated third edition of Contact Lens Practice, award-winning author, researcher and lecturer, Professor Nathan Efron, provides a comprehensive, evidence-based overview of the scientific foundation and clinical applications of contact lens fitting. The text has been refreshed by the inclusion of ten new authors - a mixture of scientists and clinicians, all of whom are at the cutting edge of their specialty. The chapters are highly illustrated in full colour and subject matter is presented in a clear and logical format to allow the reader to quickly hone in the desired information.
(source: Nielsen Book Data)9780702066603 20170814
1 online resource (xiv, 597 pages) : illustrations (some color).
  • General synthetic and physical methods-- Gadolinium-based contrast agents-- Chemical exchange saturation transfer (CEST) contrast agents-- Iron oxide nanoparticle-based contrast agents-- Transition metal-based T1 contrast agents-- Fluorine-based contrast agents-- Standard biological and in vivo methods.
  • (source: Nielsen Book Data)9781788012546 20180213
As a practical reference guide for designing and performing experiments, this book focuses on the five most common classes of contrast agents for MRI namely gadolinium complexes, chemical exchange saturation transfer agents, iron oxide nanoparticles, manganese complexes and fluorine contrast agents. It describes how to characterize and evaluate them and for each class, a description of the theory behind their mechanisms is discussed briefly to orient the new reader. Detailed subchapters discuss the different physical chemistry methods used to characterize them in terms of their efficacy, safety and in vivo behavior. Important consideration is also given to the different physical properties that affect the performance of the contrast agents. The editors and contributors are at the forefront of research in the field of MRI contrast agents and this unique, cutting edge book is a timely addition to the literature in this area.
(source: Nielsen Book Data)9781788012546 20180213
1 online resource.
  • Chapter 1: Pathophysiology of atherosclerosis Biology of the vessel wall Endothelial function Atherosclerotic plaque Risk factors (dyslipidemia, smoking, hypertension etc.) The role of inflammation The role of oxidative stress Genetics of atherosclerosis Chapter 2: Coronary artery circulation: Basic principles Functional anatomy Myocardial oxygen consumption Regulation of oxygen transport and coronary blood flow Stable angina pectoris Acute coronary syndromes Chapter 3: Novel and experimental therapies in advance atherosclerosis Anti-inflammatory treatments Anti-oxidant treatment Gene-therapy Stem-cell therapy Diagnostic strategies-novel imaging modalities-multimodalities and hybrid techniques Novel antiplatelet agents Primary percutaneous coronary intervention Novel developments in interventional strategies.
  • (source: Nielsen Book Data)9780128119082 20171204
Coronary Artery Disease: From Biology to Clinical Practice links the most important basic concepts of atherosclerosis pathophysiology to treatment management of coronary artery disease. Comprehensive coverage starts with the basic pathophysiologic mechanisms of the disease, including molecular and genetic mechanisms, cells interaction and inflammation. In addition, sections on novel anti-atherosclerotic therapies and a thorough understanding of the recent trends in clinical management round out this comprehensive tome that is ideal for practitioners and researchers. By summarizing this novel knowledge and changes in diagnostic algorithm and treatment options, this is the perfect reference for cardiology researchers who want a volume with the most up-to-date experimental trends in the field of atherosclerosis, for cardiologists and physicians who manage patients with atherosclerotic risk factors and established coronary artery disease, and medical students who want to learn the basic concepts of atherosclerosis.
(source: Nielsen Book Data)9780128119082 20171204
xii, 140 pages ; 24 cm
  • Pandemics as historical events
  • Overview of the coronary heart disease pandemic in the United States and methods of analysis
  • The emergence of the coronary heart disease pandemic in the United States, 1910-1935
  • The coronary heart disease pandemic in the United States from 1940 to 1967
  • Explanations for the emergence of the coronary heart disease pandemic
  • State differences in coronary heart disease mortality
  • Rates in the United States in 1950 and 1960
  • The emergence of the coronary heart disease pandemic in Canada and England and Wales
  • The peak and decline of the coronary heart disease pandemic in the United States, 1970 to 2010
  • Explanations for the decrease in ischemic heart disease
  • Mortality rates in the United States from 1970 to 2010
  • Decreases in state ischemic heart disease mortality rates, 1970-1990
  • The peak and decline of the pandemic in Canada, England and Wales, Western Europe, Australia and New Zealand
  • Coronary heart disease after the pandemic.
Medical Library (Lane)