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Book
1 online resource.
  • Melt-derived Bioactive Silicate Glasses-- Bioactive Glass-ceramics: Processing, Properties and Applications-- Introduction to the Structure of Silicate, Phosphate and Borate Glasses-- Molecular Dynamics Simulations of Bioactive Glass Structure and In vitro Reactivity-- Sol-Gel Glass and Nano-Macro Porous Bioscaffolds-- Tailoring of Bioactive Glasses-- Bioactive Glass Products Produced via Sintering-- Bioactive Nanoparticles, Nanofibers, and Polymeric Nanoscomposites-- Surface Functionalization of Bioactive Glasses: Reactive Groups, Biomolecules and Drugs on Bioactive Surfaces for Smart and Functional Biomaterials-- Bioactive Glass Particulate-incorporated Polymer Composites-- Phosphate Glass Fibers and Their Composites-- Organic-Inorganic Hybrid Biomaterials-- Cell Interactions with Calcium Phosphate Glasses-- Bioactive Glasses in Infection Treatment-- Bioactive Glasses for Soft Tissue Engineering Applications-- Bioactive Glasses as Carriers of Therapeutic Ions and the Biological Implications-- Mesoporous Bioactive Glasses in Tissue Engineering and Drug Delivery-- Bioactive Glasses for Nerve Regeneration-- Bioactive Silicate Glass in Implantable Medical Devices: From Research to Clinical Applications-- Glass Materials in Interventional Radiology and Interventional Oncology-- Sol-Gel-Derived Glasses for Bone Tissue Engineering.
  • (source: Nielsen Book Data)9781782629764 20170213
The global ageing society has significantly increased the need for implant materials, which not only replace damaged or lost tissue but are also able to regenerate it. The field of bioactive glasses has been expanding continuously over recent years as they have been shown to bond with hard and soft tissue, release therapeutically active ions, and be capable of enhancing bone formation and regeneration. In addition, they are successfully being used to re-mineralise teeth, thereby making bioactive glasses highly attractive materials in both dentistry and medicine. Understanding the multidisciplinary requirements set by the human body's environment and the special characteristics of the different families of bioactive glasses is a key in developing new compositions to novel clinical applications. Bioactive Glasses aims to bridge the different scientific communities associated with the field of bioactive glasses with focus on the materials science point of view. Emerging applications covered include soft tissue regeneration, wound healing, vascularisation, cancer treatment and drug delivery devices. This book provides a comprehensive overview of the latest applications of bioactive glasses for material scientists.
(source: Nielsen Book Data)9781782629764 20170213
Book
1 online resource
  • Preface xi 1 Biological Membranes 1 1.1 Introduction 1 1.2 The Biological Membranes 2 1.2.1 The Lipids and the Lipid Bilayer 4 1.2.2 The Membranes of Cells and Organelles 9 1.3 The Proteins 12 1.4 The Membrane Functions 14 1.4.1 Transport 15 1.4.2 Signal Transduction 17 1.4.3 Cell Cell Recognition 17 1.4.4 Enzymatic Activity 18 1.4.5 Intercellular Joining 18 References 19 2 Electrostatics of Biomembranes 21 2.1 The Electric Field 21 2.2 Electric Field Created by a Uniform, Infinitely Extended Planar Charge Distribution 23 2.3 The Parallel-plate Capacitor 27 2.4 The Dielectric Constant 28 2.5 The Electric Potential Across a Membrane 30 2.6 Poisson Boltzmann Equation and Gouy Chapman Theory 33 2.7 Measurement of the Charge Density of the Polar Heads of a Charged Lipid 40 2.8 Electropermeabilization of Lipid Bilayers 44 References 51 3 Thermodynamics 53 3.1 Some Concepts of ChemicalThermodynamics 53 3.2 The Electrochemical Potential 59 3.3 Thermodynamics of Irreversible Processes 61 3.4 Coupling of Primary and Secondary Active Transport in Biomembranes 68 3.4.1 Plasma Membranes of Animal Cells 70 3.4.2 Inner MitochondrialMembrane, Thylakoid Membrane, and Bacterial Plasma Membrane 71 3.4.3 Membranes of Plant and Fungal Cells 74 3.4.4 Membranes of the Vesicular System 76 References 76 4 Passive Transport 79 4.1 How do Ion Channels Look Like? 79 4.2 The Nernst Equation and the Resting Potential 84 4.3 A First Approach to the Action Potential 89 4.4 Single-channel Open Probability 94 4.4.1 The Variance 98 4.5 The Goldman Hodgkin Katz Equation 100 4.6 Open Probability and Gating Charge of Ion Channels 108 4.6.1 The Gap Junction 112 4.7 RateTheory of Membrane Transport 115 4.8 Action Potential Revisited 117 4.8.1 The Shape of the Action Potential 124 4.8.2 The Gating Current of the Potassium Channel 125 References 127 5 Active Transport 129 5.1 The Ion Pumps 129 5.2 Electromotive Force and Inversion Potential of Ion Pumps 136 5.3 Energy Levels of the Enzymatic Cycle of Ion Pumps 138 5.4 Kinetics of Ion Pumps Under Steady-State Conditions 144 5.5 Electrogenicity of the Ion Pumps 147 5.6 Kinetics of Ion Pumps Under Pre-Steady-State Conditions 150 5.6.1 Ca2+-ATPase of the Sarcoplasmic Reticulum 161 5.6.2 Na+, K+-ATPase 166 5.7 Transporters 168 5.7.1 Cotransporters 168 5.7.2 Countertransporters 170 References 172 6 BiomimeticMembranes 175 6.1 The Various Types of BiomimeticMembranes 175 6.2 Electrochemical Techniques for the Investigation of Biomimetic Membranes 177 6.2.1 Electrochemical Impedance Spectroscopy 177 6.2.2 Potential-Step Chronoamperometry (Current Time Curves) 185 6.2.3 Potential-Step Chronocoulometry 193 6.2.4 Cyclic Voltammetry 198 6.2.5 AC Voltammetry 216 6.3 Lipid Bilayers Interposed Between Two Aqueous Phases 218 6.4 Biomimetic Membranes Noncovalently Supported by Metals 224 6.4.1 Lipid Monolayers Self-Assembled on Mercury 224 6.4.2 Solid-Supported Bilayer Lipid Membranes (sBLMs) 227 6.4.3 S-Layer Stabilized Bilayer Lipid Membranes (ssBLMs) 232 6.5 Biomimetic Membranes Covalently Supported by Metals 233 6.5.1 Alkanethiol/Lipid Hybrid Bilayers 233 6.5.2 Tethered Bilayer Lipid Membranes (tBLMs) 236 6.5.3 Polymer-Cushioned Bilayer Lipid Membranes (pBLMs) 242 6.5.4 Protein-Tethered Bilayer Lipid Membranes (ptBLMs) 242 6.6 Conclusions 244 References 248 7 Auxiliary Techniques 255 7.1 Physical Properties of ElectromagneticWaves 255 7.2 Surface Plasmon Resonance 262 7.3 Infrared Spectroscopy 272 7.4 Neutron Reflectivity 279 7.5 Fluorescence Microscopy 286 7.6 Scanning Probe Microscopy 296 7.6.1 Atomic Force Microscopy 297 7.6.2 Scanning Tunneling Microscopy 302 7.7 Langmuir Blodgett and Langmuir Schaefer Transfers 305 7.8 Quartz-CrystalMicrobalance 310 References 314 Index 317.
  • (source: Nielsen Book Data)9781119271055 20170313
Invaluable to biochemists, biophysicists, and pharmacological scientists; this book provides insights into the essential principles required to understand why and how electrochemical and electrophysiological tools are fundamental in elucidating the mode of ion transport across biomembranes. Describes the essential electrochemical basics required to understand why and how electrochemical and electrophysiological tools are fundamental in elucidating the mode of ion transport across biomembranes Requires only basic physical chemistry and mathematics to be understood, without intermediate stumbling blocks that would discourage the reader from proceeding further Develops contents in a step-by-step approach that encourages students and researchers to read from beginning to end.
(source: Nielsen Book Data)9781119271055 20170313
Book
1 online resource (698 p.) : ill. (some col.)
"This book is an all-embracing review of biotechnology, biomedical engineering, bioinformatics, pharmacy and medicinal chemistry, and biopharmaceutical technology. Existing theories and the latest findings are discussed. Researchers, engineers, academics, and industry professionals will find this book an invaluable read."--Publisher's website.
Book
xv, 226 pages ; 24 cm
  • Preface Introduction: For Us, By Us: A Manifesto of Black SGL and Trans Health Jonathan Mathias Lassiter Chapter 1 The Forgotten Intersection: Black LGBTQ/GNC Youth in Juvenile Detention in the United States Amorie Robinson Chapter 2 Black Bisexual Women's Health in the United States: A Systematic Literature Review Jonathan Mathias Lassiter Chapter 3 Uses of the Interstitial as Power: Black, Bisexual Men Building Maroon Health H. Sharif "Herukhuti" Williams Chapter 4 Resistance as Resilience: How the Black Bisexual Community Keeps One Another Healthy Della V. Mosley, Roberto L. Abreu, and Candice Crowell Chapter 5 Narratives of Health among Black Trans Men: An Exploratory Intersectional Analysis Tonia C Poteat and Lourdes Dolores Follins Chapter 6 Balancing Act: Identity Management and Mental Health in Black LBT Women Siobhan Brooks Chapter 7 Rainbows or Ribbons? Queer Black Women Searching For a Place in the Cancer Sisterhood LaShaune P. Johnson and Jane A. McElroy Chapter 8 Status-Quo: Intersectionality Theory, Afro-Centric Paradigms, and Meeting the Healthcare Needs of Gay and Bisexual African American Men Dante' D. Bryant Chapter 9 Identity, Sexual Identity Disclosure, and HIV Risk in Black Sexual Minority Men: A Conceptual Overview Rahwa Haile, Mark B. Padilla, and Edith A. Parker Chapter 10 Shades of Black: A Psychotherapy Group for Black Men Who Have Sex with Men Tfawa T. Haynes and Sannisha K. Dale Chapter 11 Effective Strategies Used by African American Same Gender Loving Men in Promoting Health and Wellbeing Lawrence O. Bryant Chapter 12 Perceptions of Health: Self-Rated Health among Black LGB People Kasim Ortiz, Angelique Harris, Kenneth Maurice Pass, and Devon Tyrone Wade.
  • (source: Nielsen Book Data)9781498535762 20170130
Black LGBT Health in the United States: The Intersection of Race, Gender, and Sexual Orientation focuses on the mental, physical, and spiritual aspects of health, and considers both risk and resiliency factors for the Black LGBT population. Contributors to this collection intimately understand the associations between health and intersectional anti-Black racism, heterosexism, homonegativity, biphobia, transphobia, and social class. This collection fills a gap in current scholarship by providing information about an array of health issues like cancer, juvenile incarceration, and depression that affect all subpopulations of Black LGBT people, especially Black bisexual-identified women, Black bisexual-identified men, and Black transgender men. This book is recommended for readers interested in psychology, health, gender studies, race studies, social work, and sociology.
(source: Nielsen Book Data)9781498535762 20170130
SAL1&2 (on-campus shelving)
Book
xiv, 268 pages : illustrations ; 22 cm
  • Medicine, religion, and magic
  • The doctor in society
  • Attitudes to doctors
  • Some famous doctors
  • Anatomy
  • Sex matters
  • Women and children
  • Preventative medicine
  • Prognosis and diagnosis
  • Particular ailments and conditions
  • Treatment and cures I
  • Treatment and cures II
  • General medicine
  • Respice finem.
There are few disciplines as exciting and forward-looking as medicine. Unfortunately, however, many modern practitioners have rather lost sight of the origins of their discipline. A Cabinet of Ancient Medical Curiosities aspires to make good this lapse by taking readers back to the early days of Western medicine in ancient Greece and Rome. Quoting the actual words of ancient authors, often from texts which have never been translated into English, it gives a glimpse into the beginnings of such fields as surgery, gynecology, pediatrics, preventive medicine, and pharmacology, as well as highlighting ancient views on such familiar topics as medical ethics and the role of the doctor in society. The hundreds of passages quoted from Greek and Roman authors give a vividly direct picture of the ancient medical world, a world in which, for example, a surgeon had to be strong-minded enough to ignore the screams of his patient, diseases were assumed to be sent by the gods, medicine and magic were often indistinguishable, donkeys might be brought into the sick-room to ensure a fresh supply of milk, human anatomy and microbes were equally mysterious, and no qualifications were required before setting up as a doctor. As will be evident from this list, the approach taken in the book is not an entirely serious one. Even so, despite its lighthearted approach, it does aspire, however modestly, to engage the reader in a thought provoking way about many of the issues still current in medicine nowadays.
(source: Nielsen Book Data)9780190610432 20170220
SAL1&2 (on-campus shelving)
Book
1 online resource
Cardioskeletal Myopathies in Children and Young Adults focuses on plaques that kill people in their 40's-50's and the way they start to form in young adulthood. The Annals of Family Medicine report that approximately half of young adults have at least one cardiovascular disease risk factor (Mar 2010), and an increase in cardiovascular mortality rates in young adults was substantiated in a study at Northwestern Medicine (Nov 2011). Given the increasing recognition of genetic triggers behind all types of cardiovascular disease, and the growing population of young adults with primary or acquired myocardial disease, the need has arisen for a reference that offers a comprehensive approach to the understanding of basic, translational, and clinical aspects of specific muscle diseases while making the link between young adult and adult health. * Reveals the link between cardiac muscle disease and skeletal muscle disease* Explains how genetics and environmental factors effect muscle function of diverse origins* Designates current and novel therapeutic strategies that target both cardiac and skeletal muscle systems.
(source: Nielsen Book Data)9780128000403 20161213
Book
1 online resource (404 pages).
  • Chronic mental illnesses and homelessness / Prerna Kukreti, Prerna Khanna, Amit Khanna
  • Chronic mental illness in old age homes: an international perspective / Shamsi Akbar, Hitesh Khurana
  • Chronic mental illness and dumping patients: a concern towards management / Jyoti Mishra Pandey [and 3 others]
  • Psychosocial intervention strategies for patients with schizophrenia: in chronic mental illness / Ashwini R., Barre Vijaya Prasad, Srinivas Kosgi
  • Comorbidity issues and treatment in chronic mental illness / Deepika Srivastav, Tej Bahadur Singh
  • Management of chronic mental illnesses and substance use disorders / Pallavi Sinha, Amit Garg, Prerna Khanna, Amit Khanna
  • Understanding and management of caregivers' stress and burden of person with obsessive compulsive disorder / Shikha Soni, Poornima C., P. C. Ashfak Ahamed
  • Predictors of expressed emotion, caregiver's burden, and quality of life in chronic mental illness / Pratima Kaushik, Tej Bahadur Singh
  • Global burden of mental disorders: quality of care and unmet needs for treatment of chronic mental illness / Meghamala S. Tavaragi, Sushma C.
  • Disability in schizophrenia: the psychosocial and neurocognitive perspective / Akash Mahato, Susmita Halder
  • Chronic mental illness in prisons: global scenario / Meghamala S Tavaragi
  • Legal aspects of chronic mental illness / Raveesh B. N., Barre Vijaya Prasad, Meghamala S. Tavaragi
  • Psychosocial intervention studies for street children with substance abuse / Lakshmana G.
  • Chronic mental illness and the changing scope of intervention strategies, diagnosis, and treatment in child and adolescent population / Bhavuk Garg, Prerna Khanna, Amit Khanna
  • Advanced intervention strategies for suicide in patients with chronic mental illness / Shailesh Jha, Amit Khanna, Prerna Khanna
  • Cognitive remediation therapy in chronic schizophrenia / Susmita Halder, Akash Mahato
  • Efficacy of art therapy in treating patients with paranoid schizophrenia / Deepali Bedi
  • Psychotherapeutic interventions in emotional and behavioural problems with adolescents / Mahesh A. Tripathi, Godishala Sridevi.
Although the epidemiology of mental illnesses is innately complex, there have been many strides in the diagnosis and treatment of chronic mental illnesses as more research is being conducted in the field. As more information becomes available, mental health professionals are able to develop more effective plans for caring for their patients. Chronic Mental Illness and the Changing Scope of Intervention Strategies, Diagnosis, and Treatment examines emergent research on the identification and epidemiology of various mental illnesses. Featuring information on the prevalence of the disease, psychopharmacological advancements, and strategies for the management of chronic mental illnesses, this book is ideally suited for students, psychiatrists, psychologists, neurologists, social workers, rehabilitation therapists, and other health professionals interested in learning more about shifting practices in the mental health sector.
(source: Nielsen Book Data)9781522505198 20161213
Book
xxiv, 1068 pages : illustrations ; 21 cm
  • Sect. 1: Prenatal assessment and conditions
  • Sect. 2: Assessment and treatment in the immediate postnatal period
  • Sect. 3: General newborn condition
  • Sect. 4: Fluid electrolytes nutrition, gastrointestinal, and renal issues
  • Pt. 5: Respiratory disorders
  • Pt. 6: Cardiovascular disorders
  • Pt. 7: Hematologic disorders
  • Pt. 8: Infectious diseases
  • Pt. 9: Neurologic disorders
  • Pt. 10: Bone conditions
  • Pt. 11: Metabolism
  • Pt. 12: Endocrinology
  • Pt. 13: Surgery
  • Pt. 14: Dermatology
  • Pt. 15: Vascular anomalies
  • Pt. 16: Auditory and ophthalmologic disorders
  • Pt. 17: Common neonatal procedures
  • Pt. 18: Pain and stress control.
Medical Library (Lane)
Book
1 online resource (281 pages) : illustrations.
  • Mobile health care: a technology view / Veda Prakash Mangu
  • Cloud based wireless infrastructure for health monitoring / Ajay Chaudhary, Sateesh Kumar Peddoju, Suresh Kumar Peddoju
  • Cloud based secure data sharing algorithm for health care / Saravana Kumar N., Rajya Lakshmi Gubburi Venkataramana, Balamurugan B.
  • An adaptive cloud proto type model for health care system: an adaptive cloud proto type model for health care system using software defined network (SDN) / Drashti Dave, Nagaraju Aitha
  • Big data analytics for childhood pneumonia monitoring / Suresh Kumar Peddoju, Kavitha K., Sharma S. C.
  • Diabetes patients monitoring by cloud computing / Sepideh Poorejbari, Hamed Vahdat-Nejad, Wathiq Mansoor
  • IBM's Watson analytics for health care: a miracle made true / Mayank Aggarwal, Mani Madhukar
  • Data protection and security issues in social media / Chintan M. Bhatt
  • Trust, privacy, issues in cloud-based healthcare services / Shweta Kaushik, Charu Gandhi
  • A methodological evaluation of crypto-watermarking system for medical images / Anna Babu, Sonal Ayyappan
  • Personalized neuro-fuzzy expert system for determination of nutrient requirements / Priti Srinivas Sajja, Jeegar Ashokkumar Trivedi.
The implementation of cloud technologies in healthcare is paving the way to more effective patient care and management for medical professionals around the world. As more facilities start to integrate cloud computing into their healthcare systems, it is imperative to examine the emergent trends and innovations in the field. Cloud Computing Systems and Applications in Healthcare features innovative research on the impact that cloud technology has on patient care, disease management, and the efficiency of various medical systems. Highlighting the challenges and difficulties in implementing cloud technology into the healthcare field, this publication is a critical reference source for academicians, technology designers, engineers, professionals, analysts, and graduate students.
(source: Nielsen Book Data)9781522510024 20161213
Book
1 online resource (xxix, 182 pages)
  • History of recommendations on properties and units in clinical laboratory sciences-- Definitions of some disciplines applied in the clinical laboratory-- Conventions and instructions for use-- Fundamental concepts in communication of clinical laboratory data-- Principles and practice of kinds-of-quantity and units-- Requesting, generating, and transmitting clinical laboratory data-- Choice and use of kinds-of-quantity for different examination purposes-- Kinds-of-quantity of dimension one: SI unit 1-- Kinds-of-quantity of dimension other than one-- Kinds-of-property without dimensions of the ISQ-- Index of abbreviations used for institutions and committees-- Index of symbols for kinds-of-quantity and corresponding coherent SI units in clinical laboratory sciences.
  • (source: Nielsen Book Data)9781782621072 20170213
There has been significant expansion and development in clinical laboratory sciences and, in particular, metrological concepts, definitions and terms since the previous edition of this book was published in 1995. It is of prime importance to standardize laboratory reports for reliable exchange of patient examination data without loss of meaning or accuracy. New disciplines have appeared and the interrelationships between different disciplines within clinical laboratory sciences demand a common structure and language for data exchange, in the laboratory and with the clinicians, necessitating additional coverage in this book. These new sections will be based upon recommendations published by various national, regional, and international bodies especially IUPAC and IFCC. This book groups and updates the recommendations and will be appropriate for laboratory scientists, medical professionals and students in this area.
(source: Nielsen Book Data)9781782621072 20170213
Book
1 online resource (414 pages) : illustrations.
  • Nonlinear complexity sorting approach for 2D ECG data compression / Anukul Pandey [and 3 others]
  • A review on noninvasive beat-to-beat systemic and pulmonary blood pressure estimation through surrogate cardiovascular signals / Ana Castro [and 4 others]
  • Non-linear analysis of heart rate variability and ECG signal features of swimmers from NIT-Rourkela: a case study / Anupama Ray [and 4 others]
  • Parameter estimation of nonlinear biomedical systems using extended Kalman filter algorithm: development of patient specific models / Kamalanand Krishnamurthy
  • Two-directional two-dimensional principal component analysis based on wavelet decomposition for high-dimensional biomedical signals classification / Hong-Bo Xie, Tianruo Guo
  • Medical image enhancement using edge information-based methods / S. Anand
  • Success dimensions of ICTs in healthcare / Pankaj Deep Kaur, Pallavi Sharma
  • Non-invasive cuffless blood pressure monitoring system / Harinderjit Singh, Dilip Kumar
  • Electromyogram and inertial sensor signal processing in locomotion and transition classification / Deepak Joshi, Michael E. Hahn
  • Single electronics for biomedical applications / Deep Kamal Kaur Randhawa
  • Analysis of HRV during the menstrual cycle and postmenopause / Kirti Rawal, Barjinder Singh Saini, Indu Saini
  • A comparative study on diabetic retinopathy detection using texture-based feature extraction techniques / Azam Asilian Bidgoli, Hossein Ebrahimpour-Komleh, Seyed Jalaleddin Mousavirad
  • Analysis of electrocardiogram data compression techniques: a MATLAB-based approach / Anukul Pandey [and 3 others]
  • Energy efficient particle optimized compressed ECG data over ZigBee environment / Dilip Kumar, Rajeev Kumar, Tony Singla
  • Optimized clustering techniques with special focus to biomedical datasets / Anusuya S. Venkatesan.
Biomedical signal processing in the medical field has helped optimize patient care and diagnosis within medical facilities. As technology in this area continues to advance, it has become imperative to evaluate other ways these computation techniques could be implemented. Computational Tools and Techniques for Biomedical Signal Processing investigates high-performance computing techniques being utilized in hospital information systems. Featuring comprehensive coverage on various theoretical perspectives, best practices, and emergent research in the field, this book is ideally suited for computer scientists, information technologists, biomedical engineers, data-processing specialists, and medical physicists interested in signal processing within medical systems and facilities.
(source: Nielsen Book Data)9781522506607 20161213
Book
1 online resource (480 pages) : illustrations (some color)
Book
1 online resource (290)
  • 1. Epidemiology of Acquired Bone Marrow Failure 2. Acquired Aplastic Anemia 3. Diagnosis of Acquired Aplastic Anemia 4. Acquired Overlap Bone Marrow Failure Disorders 5. Supportive Care in Aplastic Anemia 6. Immunosuppressive Treatment for Aplastic Anemia 7. Identical Sibling Donor Transplantation 8. Unrelated Donor Transplantation 9. Cord Blood Transplantation 10. Haploidentical Transplantation 11. Management of Acquired Aplastic Anemia in Children 12. Treatment of Elderly Patients with Aplastic Anemia 13. Emerging New Therapies for Acquired Bone Marrow Failure Disorders 14. Bone Marrow Failure in Paroxysmal Nocturnal Hemoglobinuria 15. Telomere Biology and Disease 16. Fanconi Anemia 17. Ribosomopathies and the quality control of ribosome assembly 18. Dyskeratosis Congenita 19. Amegakaryocytic Thrombocytopenia 20. Severe Congenital Neutropenias and Other Rare Inherited Disorders with Marrow Failure Disorders 21. Aplastic Anemia and Myelodyspastic Syndrome in Pediatic Age.
  • (source: Nielsen Book Data)9780128041529 20170313
Congenital and Acquired Bone Marrow Failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. Chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. Content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients. Contributors are world leading experts in the field of bone marrow failure. The book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine.
(source: Nielsen Book Data)9780128041529 20170313
Book
1 online resource.
  • Front Cover; Conquering RAS: From Biology to Cancer Therapy; Conquering RAS: From Biology to Cancer Therapy; Copyright; Dedication; Contents; List of Contributors; Acknowledgments; Introduction; 01
  • RAS Cancer Biology ; 1
  • Ras and RASSF Effector Proteins ; INTRODUCTION; The RASSF Family of Proteins; RAS AND RASSF1; RAS AND RASSF5 (NORE1); RAS AND RASSF2; RAS AND RASSF3; RAS AND RASSF4 (AD037); RAS AND RASSF6; EFFECTS OF RASSF PROTEINS ON MITOGENIC RAS EFFECTORS; THERAPEUTIC RAMIFICATIONS; CONCLUSION; GLOSSARY; LIST OF ACRONYMS AND ABBREVIATIONS; REFERENCES
  • 2
  • Ras and the Hippo Pathway in Cancer INTRODUCTION; THE HIPPO TUMOR SUPPRESSOR PATHWAY; MST AND LATS AS THE CENTRAL MAMMALIAN KINASES UNDER THE INFLUENCE OF HIPPO SIGNALING; YAP SIGNALING AND ITS REGULATION BY HIPPO; CONCLUSIONS AND FUTURE DIRECTIONS; REFERENCES; 3
  • The Many Roles of Ral GTPases in Ras-Driven Cancer ; INTRODUCTION; RAL REGULATION; RalGEFs; RalGAPs; Localization; RAL EFFECTORS; RalBP1; Exocyst; Additional Effectors; RAL IN MODEL SYSTEMS; RAL IN TUMORIGENESIS; INHIBITION OF RAL; CONCLUSIONS AND FUTURE DIRECTIONS; REFERENCES
  • 4
  • The Biology, Prognostic Relevance, and Targeted Treatment of Ras Pathway-Positive Childhood Acute Lymphoblastic Leukemia INTRODUCTION; CHILDHOOD ALL; RAS PATHWAY ACTIVATION; ARE RAS PATHWAY MUTATIONS AN INITIATING OR SECONDARY EVENT?; DISEASE EVOLUTION; PROGNOSTIC SIGNIFICANCE; TARGETED THERAPIES; CONCLUSIONS; LIST OF ACRONYMS AND ABBREVIATIONS; REFERENCES; 5
  • Oncogenic KRAS and the Inflammatory Micro-Environment in Pancreatic Cancer ; ONCOGENIC KRAS DRIVES PANCREATIC CANCER DEVELOPMENT; THE IMPORTANCE OF INFLAMMATION IN PDAC DEVELOPMENT
  • INTER-RELATION BETWEEN ONCOGENIC KRAS AND INFLAMMATION IN PANCREATIC CANCEROncogenic Kras Induces Inflammatory Pathways in Pancreatic Cancer; Inflammation Reciprocally Promotes Kras Over-activation; OBESITY-RELATED INFLAMMATION PROMOTES PANCREATIC CANCER DEVELOPMENT; POTENTIAL TARGETS FOR INTERVENTIONS; CONCLUSION; LIST OF ACRONYMS AND ABBREVIATIONS; REFERENCES; 6
  • Activation of Ras by Post-Translational Modifications ; INTRODUCTION; POST-TRANSLATIONAL MODIFICATIONS OF RAS; Prenylation; The CAAX Processing; The Enzymes for Prenylation; Farnesyltransferase; Geranylgeranyltransferase Type I
  • Ras Converting Enzyme 1Isoprenylcysteine Carboxyl Methyltransferase; Targeting Ras Prenylation; Palmitoylation and De-palmitoylation Cycle; Phosphorylation; Ubiquitination; Acetylation; S-Nitrosylation; Bacterial Toxins and Exoenzymes; CONCLUSIONS; LIST OF ACRONYMS AND ABBREVIATIONS; ACKNOWLEDGMENT; REFERENCES; 7
  • Cross Talk Between Snail and Mutant K-Ras Contributes to Pancreatic Cancer Progression ; INTRODUCTION; K-RAS AND PANCREATIC CANCER PROGRESSION; EPITHELIAL-TO-MESENCHYMAL TRANSITION AND PANCREATIC CANCER PROGRESSION
Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient’s bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS.Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities. Showcases recent advancements in RAS research under one comprehensive volume. Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research.
Book
1 online resource.
  • Section 1: Care in the neurosciences intensive care unit 1. The history of neurocritical care 2. Airway management and mechanical ventilation in acute brain injury 3. Neuropulmonology 4. Neurocardiology 5. Principles of intracranial pressure monitoring and treatment 6. Multimodal neurologic monitoring 7. Continuous EEG monitoring in the intensive care unit 8. Management of the comatose patient 9. Management of status epilepticus 10. Critical care in acute ischemic stroke 11. Management of intracerebral hemorrhage 12. Management of aneurysmal subarachnoid hemorrhage 13. Management of acute neuromuscular disorders 14. Critical care management of traumatic brain injury 15. Management of acute traumatic spinal cord injuries 16. Decompressive craniectomy in acute brain injury 17. Diagnosis and management of spinal cord emergencies 18. Diagnosis and management of acute encephalitis 19. Management of bacterial central nervous system infections 20. Management of infections associated with neurocritical care 21. Determinants of prognosis in neurocatastrophes 22. Family discussions on life-sustaining interventions in neurocritical care 23. Organ donation protocols.
  • (source: Nielsen Book Data)9780444636003 20170313
Critical Care Neurology, Part I: Neurocritical Care focuses on the care specialists and general neurologists that consult in the ICU and their work with patients in acute, life-threatening situations who are dealing with neurologic or neurosurgical crises emanating from either a preexisting neurologic syndrome or from a new neurologic complication appearing as a result of another medical or surgical critical illness. These two separate clinical situations form the pillars of neurocritical care, hence these practices are addressed via two separate, but closely related, HCN volumes. Chapters in both focus on pathophysiology and management, and are tailored for both general neurologists and active neurocritical specialists, with a specific focus on management over diagnostics. Part I addresses the principles of neurocritical care and the management of various neurologic diseases. Part II addresses the interplay between neurologic complications and the surgical, medical, cardiac, and trauma of critical illnesses that most typically present in the ICU.
(source: Nielsen Book Data)9780444636003 20170313
Book
1 online resource.
  • Section 2: Neurologic complications of critical illness 24. The scope of neurology of critical illness 25. Delirium in critically ill patients 26. Posterior reversible encephalopathy in the intensive care unit 27. Acute neurotoxicology of drugs of abuse 28. Seizures in the critically ill 29. Intensive care unit-acquired weakness 30. Neurologic complications of transplantation 31. Neurologic complications of cardiac and vascular surgery 32. Neurology of cardiopulmonary resuscitation 33. Therapeutic hypothermia protocols 34. Neurologic complications of polytrauma 35. Neurologic complications in critically ill pregnant patients 36. Neurologic complications of sepsis 37. Neurologic complications of acute environmental injuries 38. Neurologic manifestations of major electrolyte abnormalities 39. Management of neuro-oncologic emergencies 40. Management of neurologic complications of coagulopathies 41. Prognosis of neurologic complications in critical illness.
  • (source: Nielsen Book Data)9780444635990 20170313
Critical Care Neurology, Part II: Neurology of Critical Illness focuses on the care specialists and general neurologists that consult in the ICU and their work with patients in acute, life-threatening situations who are dealing with neurologic or neurosurgical crises emanating from either a preexisting neurologic syndrome or from a new neurologic complication appearing as a result of another medical or surgical critical illness. These two separate clinical situations form the pillars of neurocritical care, hence these practices are addressed via two separate, but closely related, HCN volumes. Chapters in both focus on pathophysiology and management, and are tailored for both general neurologists and active neurocritical specialists, with a specific focus on management over diagnostics. Part I addresses the principles of neurocritical care and the management of various neurologic diseases. Part II addresses the interplay between neurologic complications and the surgical, medical, cardiac, and trauma of critical illnesses that most typically present in the ICU.
(source: Nielsen Book Data)9780444635990 20170313
Book
xxiv, 252 pages : illustration ; 24 cm.
  • Foreword Patricia Arredondo Part I: Socio-Cultural Foundations 1. The Diverse Historical Roots of Today's Latino/as: Learning from our Past to Move into the Future 2. Skin Color Differences within Latino/as: Historical & Contemporary Implications of Colorism 3. The History of Latino/a in the United States: Journeys of Hope, Struggle, & Resilience Part II: Understanding Within Group Latino/a Differences 4. Socio-historical Construction of Latina/o Gender Ideologies: Integrating Indigenous and Contemporary Perspectives into Treatment 5. Adapting to a New Country: Models & Theories of Acculturation Applied to the Diverse Latino/a Population 6. Skin Color Matters: Towards a New Framework that Considers Racial and Ethnic Identity Development Among Latino/as Part III: Culturally Responsive and Racially Conscious Clinical Practice with Latino/as 7. Towards a Complex Understanding of Mental Health Service Utilization among Latino/as: Considering Context, Power, and Within Group Differences 8. Roots of Connectedness: Application of Latino/a Cultural Values in Mental Health Care 9. Culturally Responsive and Racially Conscious Mental Health Approaches with Latino/as Part IV: The Impact of Latino/a Psychology on Racially & Ethnically Diverse Students and Professionals 10. The Impact of Latino/a Psychology on Racially & Ethnically Diverse Students and Professionals.
  • (source: Nielsen Book Data)9781138851535 20161108
Advancing work to effectively study, understand, and serve the fastest growing U.S. ethnic minority population, this volume explicitly emphasizes the racial and ethnic diversity within this heterogeneous cultural group. The focus is on the complex historical roots of contemporary Latino/as, their diversity in skin-color and physiognomy, racial identity, ethnic identity, gender differences, immigration patterns, and acculturation. The work highlights how the complexities inherent in the diverse Latino/a experience, as specified throughout the topics covered in this volume, become critical elements of culturally responsive and racially conscious mental health treatment approaches. By addressing the complexities, within-group differences, and racially heterogeneity characteristic of U.S. Latino/as, this volume makes a significant contribution to the literature related to mental health treatments and interventions.
(source: Nielsen Book Data)9781138851535 20161108
SAL1&2 (on-campus shelving)
Book
1 online resource (124 p).
  • Cancer Gene therapy trials worldwide.- Viral vectors for cancer gene therapy.- Nonviral vectors for cancer gene therapy.- Delivery systems for cancer gene therapy.- Targeted vectors for cancer gene therapy.- Current strategies for cancer suicide gene therapy.- Stem cell guided gene therapy for cancer.- Gene replacement therapy to treat cancer.- miRNA for cancer gene therapy.- Gene suppression gene therapy for cancer.- Recent developments in oncolytic virus therapy.- DNA vaccination for cancer therapy.- mRNA based cancer vaccines.- Engineered T-cells to treat cancer.- Gene therapy for overcoming drug resistance.
  • (source: Nielsen Book Data)9783319429328 20170313
This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book also details parallel improvements in vector design, vector delivery, and therapeutic efficacy. It offers readers a stimulating, broad overview of advances in the field, linking experimental strategies to their clinical applications.
(source: Nielsen Book Data)9783319429328 20170313
Book
xviii, 211 pages ; 24 cm
  • Preface to the First Edition-- Preface to the Second Edition-- The Myth of Mental Illness-- That Discreet Object of Desire-- Ressentiment: An Existential Paradigm for Symptom Formation-- Deciphering "Psychopathology"-- What to Make of an Incidence of Incomprehensible Madness (or A Clinical Case Not so Easy to Diagnose)-- The Unobjectionable Transference-- Love and Madness-- On Sanity.
  • (source: Nielsen Book Data)9781138790223 20160928
A stunning exploration of the relation between desire and psychopathology, The Death of Desire is a unique synthesis of the work of Laing, Freud, Nietzsche, and Heidegger that renders their often difficult concepts brilliantly accessible to and usable by psychotherapists of all persuasions. In bridging a critical gap between phenomenology and psychoanalysis, M. Guy Thompson, one of the leading existential psychoanalysts of our time, firmly re-situates the unconscious - what Freud called "the lost continent of repressed desires" - in phenomenology. In so doing, he provides us with the richest, most compelling phenomenological treatment of the unconscious to date and also makes Freud's theory of the unconscious newly comprehensible. In this revised and updated second edition to the original published in 1985, M. Guy Thompson takes us inside his soul-searching seven-year apprenticeship with radical psychiatrist R. D. Laing and his cohorts as it unfolded in counterculture London of the 1970s. This rite de passage culminates with a four-year sojourn inside one of Laing's post-Kingsley Hall asylums, where Laing's unorthodox conception of treatment dispenses with conventional boundaries between "doctor" and "patient." In this unprecedented exploration, Thompson reveals the secret to Laing's astonishing alternative to the conventional psychiatric and psychoanalytic treatment schemes. Movingly written and deeply personal, Thompson shows why the very concept of "mental illness" is a misnomer and why sanity and madness should be understood instead as inherently puzzling stratagems that we devise in order to protect ourselves from intolerable mental anguish. The Death of Desire offers a provocative and challenging reappraisal of depth psychotherapy from an existential perspective that will be of interest to psychoanalysts, psychotherapists, philosophers, social scientists, and students of the human condition.
(source: Nielsen Book Data)9781138790223 20160928
SAL1&2 (on-campus shelving)
Book
1 online resource.
  • PART 1: INTRODUCTION 1. An introduction to neural network and deep learning (covering CNN, RNN, RBM, Autoencoders) (Heung-Il Suk) 2. An Introduction to Deep Convolutional Neural Nets for Computer Vision (Suraj Srinivas, Ravi K. Sarvadevabhatla, Konda R. Mopuri, Nikita Prabhu, Srinivas S.S. Kruthiventi and R. Venkatesh Babu) PART 2: MEDICAL IMAGE DETECTION AND RECOGNITION 3. Efficient Medical Image Parsing (Florin C. Ghesu, Bogdan Georgescu and Joachim Hornegger) 4. Multi-Instance Multi-Stage Deep Learning for Medical Image Recognition (Zhennan Yan, Yiqiang Zhan, Shaoting Zhang, Dimitris Metaxas and Xiang Sean Zhou) 5. Automatic Interpretation of Carotid Intima-Media Thickness Videos Using Convolutional Neural Networks (Nima Tajbakhsh, Jae Y. Shin, R. Todd Hurst, Christopher B. Kendall and Jianming Liang) 6. Deep Cascaded Networks for Sparsely Distributed Object Detection from Medical Images (Hao Chen, Qi Dou, Lequan Yu, Jing Qin, Lei Zhao, Vincent C.T. Mok, Defeng Wang, Lin Shi and Pheng-Ann Heng) 7. Deep Voting and Structured Regression for Microscopy Image Analysis (Yuanpu Xie, Fuyong Xing and Lin Yang) PART 3 MEDICAL IMAGE SEGMENTATION 8. Deep Learning Tissue Segmentation in Cardiac Histopathology Images (Jeffrey J. Nirschl, Andrew Janowczyk, Eliot G. Peyster, Renee Frank, Kenneth B. Margulies, Michael D. Feldman and Anant Madabhushi) 9. Deformable MR Prostate Segmentation via Deep Feature Learning and Sparse Patch Matching (Yanrong Guo, Yaozong Gao and Dinggang Shen) 10. Characterization of Errors in Deep Learning-Based Brain MRI Segmentation (Akshay Pai, Yuan-Ching Teng, Joseph Blair, Michiel Kallenberg, Erik B. Dam, Stefan Sommer, Christian Igel and Mads Nielsen) PART 4 MEDICAL IMAGE REGISTRATION 11. Scalable High Performance Image Registration Framework by Unsupervised Deep Feature Representations Learning (Shaoyu Wang, Minjeong Kim, Guorong Wu and Dinggang Shen) 12. Convolutional Neural Networks for Robust and Real-Time 2-D/3-D Registration (Shun Miao, Jane Z. Wang and Rui Liao) PART 5 COMPUTER-AIDED DIAGNOSIS AND DISEASE QUANTIFICATION 13. Chest Radiograph Pathology Categorization via Transfer Learning (Idit Diamant, Yaniv Bar, Ofer Geva, Lior Wolf, Gali Zimmerman, Sivan Lieberman, Eli Konen and Hayit Greenspan) 14. Deep Learning Models for Classifying Mammogram Exams Containing Unregistered Multi-View Images and Segmentation Maps of Lesions (Gustavo Carneiro, Jacinto Nascimento and Andrew P. Bradley) 15. Randomized Deep Learning Methods for Clinical Trial Enrichment and Design in Alzheimer's Disease (Vamsi K. Ithapu, Vikas Singh and Sterling C. Johnson) 16. Deep Networks and Mutual Information Maximization for Cross-Modal Medical Image Synthesis (Raviteja Vemulapalli, Hien Van Nguyen and S.K. Zhou) 17. Natural Language Processing for Large-Scale Medical Image Analysis Using Deep Learning (Hoo-Chang Shin, Le Lu and Ronald M. Summers) Index.
  • (source: Nielsen Book Data)9780128104088 20170313
Deep learning is providing exciting solutions for medical image analysis problems and is seen as a key method for future applications. This book gives a clear understanding of the principles and methods of neural network and deep learning concepts, showing how the algorithms that integrate deep learning as a core component have been applied to medical image detection, segmentation and registration, and computer-aided analysis, using a wide variety of application areas. Deep Learning for Medical Image Analysis is a great learning resource for academic and industry researchers in medical imaging analysis, and for graduate students taking courses on machine learning and deep learning for computer vision and medical image computing and analysis.
(source: Nielsen Book Data)9780128104088 20170313