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Alcohol Use Disorders takes a life-span/developmental approach to understanding the etiologic processes that heighten risk or resilience factors for alcohol use disorders (AUD).
(source: Nielsen Book Data)9780190676001 20180205
Book
xxiv, 372 pages ; 23 cm
'Written with perceptive sympathy for the wounded healer, it is necessary reading for both doctors and patients.' Hilary Mantel 'Crucial and timely.' Atul Gawande 'A furious dispatch from the front line of the hospital system.' The Times, 'Book of the Week' 'Fascinating and troubling. Read it and weep.' Susie Orbach 'Haunting, beautiful and urgent.' Johann Hari 'At the heart of this book is the problem of how emotional resilience can be identified in prospective doctors and strengthened in practising doctors. We are fallible human beings, not omniscient gods.' Henry Marsh, Sunday Times Doctors are the people we turn to when we fall ill. They are the people we trust with our lives, and with the lives of those we love. Yet who can doctors turn to at moments of stress, or when their own working lives break down? What does it take to confront death, disease, distress and suffering every day? To work in a healthcare system that is stretched to breaking point? To carry the responsibility of making decisions that can irrevocably change someone's life - or possibly end it? And how do doctors cope with their own questions and fears, when they are expected to have all the answers? Caroline Elton is a psychologist who specialises in helping doctors. For over twenty years she has listened as doctors have unburdened themselves of the pressures of their jobs: the obstetrician whose own fertility treatment failed; the trainee oncologist who found herself unable to treat patients suffering from the disease that killed her father; the brilliant neurosurgeon struggling to progress her career in an environment that was hostile to women. Drawing on extraordinary case studies and decades of work supporting clinicians, Also Human presents a provocative, perceptive and deeply humane examination of the modern medical profession.
(source: Nielsen Book Data)9781785150906 20180521
Green Library
Book
xix, 232 pages : illustrations ; 24 cm
  • Contents and AbstractsIntroduction: When Arabs Fled: A Legacy of Conflict chapter abstractNo world region has been more affected by political violence than the Middle East. Prior to 2011, fifteen of the twenty-two Middle Eastern nation-states had suffered from protracted conflicts. Directly and indirectly, the United States has participated in this violence through its long history of military intervention, especially in Iraq and Afghanistan. Since the Arab uprisings of 2011, three new wars have emerged in the Middle East, including the devastating war in Syria. Arabs now constitute the largest percentage of refugees and internally displaced persons in the world. This chapter explores these wars, as well as the flight of Arab refugees to the United States, and introduces readers to the Arab ethnic enclave community known as "Arab Detroit, " where the author conducted a five-year anthropological study on the poverty, vulnerability, and reproductive health challenges facing Arab refugees in America. 1Why They Fled: War and the Health Costs of Conflict chapter abstractThis chapter highlights the devastating impact of war on human health. Focusing on war "syndemics, " or the interlocking health problems that surface and often kill during times of political violence, Chapter 1 examines the health costs of war in Lebanon and Iraq, the two home countries from which most residents of Arab Detroit fled. Wars in Iraq and Lebanon generated physical, mental, and reproductive health problems, as well as damage to the social structure, infrastructure, and environment. These health costs of conflict are shown through the war stories of several Lebanese and Iraqi men and women, who arrived in the United States after surviving the misery of war. As their stories show, Arab Detroit is home to many traumatized war victims, who attribute their ongoing reproductive health problems to war and its effects. 2Where They Resettled: Poverty on the Margins of Detroit chapter abstractThis chapter focuses on Arab refugee resettlement in the United States. It questions the strategies of the US Refugee Admissions Program (USRAP), including the quantity and quality of assistance given to Arab refugees, especially from Iraq. The chapter asks whether refugee resettlement in economically struggling cities such as Detroit has been a wise decision. It also compares the concentrated poverty and discrimination facing both black and Arab Detroit residents. Poverty affects their ability to secure safe housing, stable employment and education, and the means to improve their standard of living. This chapter thus locates Arab poverty on the margins of Detroit, now the nation's poorest large city. Arab refugees placed in Detroit face many forms of structural vulnerability, the effects of which are shown in this chapter. 3How They Struggle: Health Disparities and Unequal Treatment chapter abstractThis chapter explores the health struggles and reproductive health disparities facing Arab refugees. Drawing inspiration from intersectionality theory forwarded by black feminist scholars, this chapter depicts the reproductive racism faced by both blacks and Arabs, who are seen as "undeserving" reproducers of "black and brown babies" (and future "terrorists, " in the case of Arab refugees). Yet infertility is a major reproductive health problem for both of these populations. Among Arab refugees, men in particular face severe male infertility problems, partly due to the stresses, injuries, and toxins of war. In vitro fertilization (IVF) services are costly in the United States-approximately $12,500 per cycle-and rarely covered by insurance. Thus, affording IVF is a profound challenge for impoverished Arab couples, who are effectively banished from the world of test-tube baby making. 4What They Feel: Reproductive Exile between Moral Worlds chapter abstractThis chapter examines the existential feelings of exile among infertile couples in Arab Detroit, who find themselves straddling American secular and Muslim moral worlds in their quests for conception. Islamic religious authorities have condoned IVF to overcome infertility, leading to the growth of a robust IVF industry in the Muslim world. Some infertile Arab couples are able to undertake "reproductive tourism" back to their home countries for this purpose. However, for Iraqi refugees, their home country has been decimated by ongoing war, ISIS violence, and a shattered medical system. Thus, they exist in a state of "reproductive exile, " unable to return home but also unable to access IVF in the United States, the most costly nation in the world. Because marriage and parenthood are normative dimensions of adult personhood for Arab couples, reproductive exile may invoke marital crises, as Arab men and women face pressure to achieve their reproductive dreams. Conclusion: Arab Lives Matter: Why America Must Care chapter abstractThe conclusion looks to the future, asking what will happen to vulnerable Arab refugee populations around the world. Four important strategies for improving refugee welfare are described. They include stopping wars in the Middle East, saving war orphans and uprooted Arab families, taking better care of Arab refugees in America, and ensuring health equity and reproductive justice for poor Arab couples, through a global movement for low-cost in vitro fertilization (LCIVF). Given the ongoing wars in the Middle East and the world's worst refugee crisis since WWII, Americans must take a stronger moral stance against war and do more to advocate for refugee health and well-being. Given all that they have lost, Arab refugees deserve to rebuild their family lives in America. Arab lives do matter, and America must care.
  • (source: Nielsen Book Data)9780804786393 20180508
America's Arab Refugees is a timely examination of the world's worst refugee crisis since World War II. Tracing the history of Middle Eastern wars-especially the U.S. military interventions in Iraq and Afghanistan-to the current refugee crisis, Marcia C. Inhorn examines how refugees fare once resettled in America. In the U.S., Arabs are challenged by discrimination, poverty, and various forms of vulnerability. Inhorn shines a spotlight on the plight of resettled Arab refugees in the ethnic enclave community of "Arab Detroit, " Michigan. Sharing in the poverty of Detroit's Black communities, Arab refugees struggle to find employment and to rebuild their lives. Iraqi and Lebanese refugees who have fled from war zones also face several serious health challenges. Uncovering the depths of these challenges, Inhorn's ethnography follows refugees in Detroit suffering reproductive health problems requiring in vitro fertilization (IVF). Without money to afford costly IVF services, Arab refugee couples are caught in a state of "reproductive exile"-unable to return to war-torn countries with shattered healthcare systems, but unable to access affordable IVF services in America. America's Arab Refugees questions America's responsibility for, and commitment to, Arab refugees, mounting a powerful call to end the violence in the Middle East, assist war orphans and uprooted families, take better care of Arab refugees in this country, and provide them with equitable and affordable healthcare services.
(source: Nielsen Book Data)9780804786393 20180508
Green Library
Book
xxii, 213 pages : illustrations ; 23 cm
Green Library
Book
1 online resource (736 pages).
  • 1. Discovery of Artemisinin and History of Research and Discovery of Artemisinin Antimalarials; 2. Biological Research of Artemisia annua L; 3. Chemical Research on Artemisinin; 4. Artemisinin Derivatives and Analogues; 5. Pharmacological Study on Artemisinin and Its Derivatives; 6. Clinical Studies of Artemisinin and its Derivatives; 7. Artemether and Lumefantrine Combination; 8. Artemisinin and Naphthoquine Phosphate Combination; 9. The Combination of Artemisinin Drugs and Pyronaridine; 10. Artemisinins and piperaquine phosphate combinations
Book
xi, 310 pages : color illustrations ; 29 cm
  • Preparation techniques
  • Intraoperative cytology
  • Gynecologic system
  • Respiratory system
  • Hematopathology
  • Genitourinary system
  • Pancreatobiliary, liver, and gastrointestinal tract
  • Head and neck (includes thyroid)
  • Bone and soft tissue
  • Central nervous system
  • Mediastinum, retroperitoneum, and adrenal glands
  • Ancillary testing.
Medical Library (Lane)
Book
xix, 428 pages : illustrations ; 24 cm
Green Library
Book
x, 302 pages : illustrations ; 24 cm.
  • Acknowledgments vii Introduction. Involution 1 1. Intention 35 2. Intervention 89 3. Invitation 135 4. Invention 175 Epilogue. Indexicality 207 Notes 215 Bibliography 261 Index 289.
  • (source: Nielsen Book Data)9780822370208 20180129
In Authoring Autism Melanie Yergeau defines neurodivergence as an identity-neuroqueerness-rather than an impairment. Using a queer theory framework, Yergeau notes the stereotypes that deny autistic people their humanity and the chance to define themselves while also challenging cognitive studies scholarship and its reification of the neurological passivity of autistics. She also critiques early intensive behavioral interventions-which have much in common with gay conversion therapy-and questions the ableist privileging of intentionality and diplomacy in rhetorical traditions. Using storying as her method, she presents an alternative view of autistic rhetoricity by foregrounding the cunning rhetorical abilities of autistics and by framing autism as a narrative condition wherein autistics are the best-equipped people to define their experience. Contending that autism represents a queer way of being that simultaneously embraces and rejects the rhetorical, Yergeau shows how autistic people queer the lines of rhetoric, humanity, and agency. In so doing, she demonstrates how an autistic rhetoric requires the reconceptualization of rhetoric's very essence.
(source: Nielsen Book Data)9780822370208 20180129
Green Library

29. Backing out of time [2015]

Video
1 streaming video file (59 min.) : digital, sound, color
Over a three-year period, this film balances the honest emotions and real concerns of five diverse families as they navigate a new and often sudden terrain--that of caregiving. It is an upbeat look at the adjustments and compromises these families make as they learn how to care for their loved one with Alzheimer's.
Book
ix, 156 pages ; 24 cm.
  • Chapter 1: The Realm of Violence: An Overview by Salman Akhtar and Shawn Blue Chapter 2: Learning the Difference between Hate and Violence by Kerry Kelly Novick Chapter 3: Rage, Violence, and Terrorism by Ann G Smolen Chapter 4: Gods Do Not Negotiate: A Psycho-Historical Look at Terrorism by Vamik Volkan, Chapter 5: The Roles of Essentialism and Religion as Scaffolds to Terrorism: Some Psycho-historical Considerations by Vincenzo Sanguineti Chapter 6: Hateful Feelings in the Transference and Countertransference by Aisha Abbasi Chapter 7: From Rage to Obliteration: Prejudice in the Analytic Dyad by Suzanne Benser Chapter 8: Experience-generated Hostile Destructiveness Fuels Hate, Violence, and Terrorism: a Concluding Commentary by Henri Parens.
  • (source: Nielsen Book Data)9781498568586 20180430
From childhood onwards, humans use their environment's responses to construct models or schemata to link feelings and impulses with actions and effects. If the environment during those formative years is unreliable, frustrating, or violating, the construction of those internal models can be disrupted and create a disjointed perception of the world, where violence is the only way to feel strong or good about oneself. Before and After Violence explores the complex network of experiences and relationships that contribute to both the origins and consequences of violence, starting in the early stages of life and compounding over time. The contributors to this collection examine the different settings in which violence takes place, look at the variables that propel its occurrence in local and global instances, and depict how each can be traced back to profound feelings of betrayal, helplessness, and anger that manifest in the physical discharges of aggression towards a single person or a whole group. Through a psychoanalytic lens, the contributors analyze and explain violence in its many forms, delve into its myriad of causes, as well as offer a variety of solutions that can be applied to various instances of violence whether it be physical or mental, self-directed or other-directed.
(source: Nielsen Book Data)9781498568586 20180430
Green Library
Book
xvii, 354 pages ; 23 cm
  • Big data and individual autonomy in a crowd / Barbara J. Evans
  • Big data's epistemology and its implications for precision medicine and privacy / Jeffrey M. Skopek
  • Big data's epistemology and its implications for precision medicine and privacy / Tal Z. Zarsky
  • Correlation vs. causation in health-related big data analysis : the role of reason and regulation / Tal Z. Zarsky
  • Big data and regulatory arbitrage in healthcare / Nicolas P. Terry
  • The future of pharmacovigilance : big data and the False Claims Act / Efthimios Parasidis
  • Big data's new discrimination threats : amending the Americans with Disabilities Act to cover discrimination based on data-driven predictions of future disease / Sharona Hoffman
  • Who's left out of big data? How big data collection, analysis, and use neglects populations most in need of medical and public health research and interventions / Sarah E. Malanga, Jonathan D. Loe, Christopher T. Robertson, Kenneth S. Ramos
  • Potential roadblocks in health care big data collection : Gobeille v. Liberty Mutual, ERISA, and all-payer claims databases / Carmel Shachar, Aaron S. Kesselheim, Gregory Curfman, Ameet Sarpatwari
  • Avoiding over-regulation in the medical Internet of things / Dov Greenbaum
  • Data policy for Internet of things health care devices : aligning patient, industry, and privacy goals in the age of big data / Marcus Comiter
  • Thought leader perspectives on risks in precision medicine research / Laura M. Beskow, Catherine M. Hammack, Kathleen M. Brelsford, Kevin C. McKenna
  • From individual to group privacy in biomedical big data / Brent Mittelstadt
  • Big data and informed consent : the case of estimated data / Donna M. Gitter
  • Is there a duty to share health care data? / I. Glenn Cohen
  • Societal lapses in protecting individual privacy, the common rule, and big data health research / Laura Odwazny
  • Common rule and research with data, big and small / Liza Dawson
  • Big data, HIPAA and the common rule : time for big change? / Margaret Foster Riley
  • Data sharing that enables post-approval drug and device research and protects patient privacy : best practice recommendations / Ameet Sarpatwari, Bradley A. Malin, Aaron S. Kesselheim, Joshua J. Gagne, Sebastian Schneeweiss
  • Big data and human medical judgment : regulating next generation clinical decision support / Jeffrey M. Senger, Patrick O'Leary
  • Medical malpractice and black-box medicine / W. Nicholson Price II
  • Big data & intellectual property rights in the health and life sciences / Timo Minssen, Justin Pierce
  • The pathologies of data-generating patents / Ted Sichelman, Brenda M. Simon.
Law Library (Crown)
Book
1 online resource.
Book
vii, 292 pages : illustrations, map ; 25 cm
  • Part I: The cerebral mystique. Eating the brain ; Humor me ; It's complicated ; Scanning for Godot ; Thinking, outside the box ; No brain is an island
  • Part II: The importance of being biological. Insiders and outsiders ; Beyond the broken brain ; Neurotechnology unbound ; What it's like to be in a vat.
A pioneering neuroscientist argues that we are more than our brains To many, the brain is the seat of personal identity and autonomy. But the way we talk about the brain is often rooted more in mystical conceptions of the soul than in scientific fact. This blinds us to the physical realities of mental function. We ignore bodily influences on our psychology, from chemicals in the blood to bacteria in the gut, and overlook the ways that the environment affects our behavior, via factors varying from subconscious sights and sounds to the weather. As a result, we alternately overestimate our capacity for free will or equate brains to inorganic machines like computers. But a brain is neither a soul nor an electrical network: it is a bodily organ, and it cannot be separated from its surroundings. Our selves aren't just inside our heads--they're spread throughout our bodies and beyond. Only once we come to terms with this can we grasp the true nature of our humanity.
(source: Nielsen Book Data)9780465052684 20180430
Green Library
Book
1 online resource.
  • Front Cover; Biomedical Applications of Functionalized Nanomaterials; Biomedical Applications of Functionalized Nanomaterials; Copyright; Contents; List of Contributors; Preface; REFERENCES; 1
  • From the â#x80; #x9C; Magic Bulletâ#x80; #x9D; to Advanced Nanomaterials for Active Targeting in Diagnostics and Therapeutics; 1. PAUL EHRLICH AND THE â#x80; #x9C; MAGIC BULLETâ#x80; #x9D; ; 2. PASSIVE VERSUS ACTIVE TARGETING IN CANCER AS MODEL; 2.1 SUGARS; 2.2 TRANSFERRIN AND LACTOFERRIN; 2.3 FOLIC ACID; 2.4 HYALURONIC ACID; 2.5 ANTIBODIES; 2.6 APTAMERS; 3. EMERGING CHALLENGES AND PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES
  • I
  • Ligand Selection and Functionalization of Nanomaterials2
  • Conjugation Chemistry Principles and Surface Functionalization of Nanomaterials; 1. CONJUGATION CHEMISTRY IN THE CONTEXT OF BIOMEDICAL NANOMATERIALS; 2. CONJUGATION CHEMISTRY PRINCIPLES; 2.1 AMINE REACTIONS; 2.1.1 Amide Bond Formation: Strategies; 2.1.1.1 Acyl Halides; 2.1.1.2 Acyl Azides; 2.1.1.3 Acylimidazoles; 2.1.1.4 Anhydrides; 2.1.1.5 O-Acylisourea Using Carbodiimides as Coupling Reagents; 2.1.1.6 Active Esters; 2.1.1.7 Staudinger Ligation; 2.1.1.8 Microwave Activation; 2.1.2 Phosphoramidate Formation: Strategies
  • 2.2 THIOL REACTIONS2.2.1 Thioether Bond Formation: Addition of Thiols at Multiple Bonds of Unsaturated Compounds; 2.2.2 Disulfide Bridge; 2.3 HYDROXYL REACTIONS; 2.3.1 Ester Bond Formation: Strategies; 2.3.1.1 Acyl Halides, Anhydrides, and O-Acylisoureas via Carbodiimide Coupling; 2.3.1.2 Mitsunobu Coupling; 2.3.2 Carbamate Linkage Formation: Strategies; 2.4 CARBOXYLIC ACID REACTIONS; 2.5 ALDEHYDES AND KETONES REACTIONS; 2.6 ALKENES AND ALKYNES; 2.6.1 Dielsâ#x80; #x93; Alder Cycloaddition; 2.6.2 Click Chemistry; 2.6.2.1 Huisgen 1,3-Dipolar Azideâ#x80; #x93; Alkyne Cycloadditions; 2.7 PHOTOCHEMICAL REACTIONS
  • 3. SELF-ASSEMBLED MONOLAYERS AS A POWERFUL TOOL FOR THE DESIGN OFâ#x80; S̄URFACE-ENGINEERED NANOMATERIALS3.1 BIOMOLECULES CONJUGATION ONTO SELF-ASSEMBLED MONOLAYERS VIA COVALENT BINDING; 3.1.1 Maleimide-Terminated Self-Assembled Monolayers; 3.1.2 Alkyne or Azide-Terminated Self-Assembled Monolayersâ#x80; (̄â#x80; #x9C; Click Chemistryâ#x80; #x9D; ); 3.1.3 Carboxylic Acid-Terminated Self-Assembled Monolayers; 3.1.4 Hydroxyl-Terminated Self-Assembled Monolayers; 3.2 BIOMOLECULES CONJUGATION ON SELF-ASSEMBLED MONOLAYERS VIAâ#x80; ĀFFINITY BINDING; 4. CHALLENGES IN (BIO)CONJUGATION; REFERENCES
  • 3
  • Phage Display Technology for Selection of Antibody Fragments1. INTRODUCTION; 2. ANTIBODY PHAGE DISPLAY LIBRARIES; 2.1 ANTIBODIES FROM NAÃ#x8F; VE AND IMMUNE PHAGE DISPLAY LIBRARIES; 2.2 ANTIBODIES FROM SYNTHETIC AND SEMISYNTHETIC PHAGE DISPLAY LIBRARIES; 3. SELECTION AND SCREENING OF ANTIBODY PHAGE DISPLAY LIBRARIES; 4. ANTIBODY ENGINEERING; 4.1 AFFINITY MATURATION OF ANTIBODIES; 4.2 HUMANIZATION OF ANTIBODIES; 5. CONCLUSIONS AND FUTURE PERSPECTIVES; REFERENCES; 4
  • Ribosome Display Technology for Selecting Peptide and Protein Ligands; 1. INTRODUCTION
Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies.
Book
1 online resource.
  • List of Contributors xi Preface xv Acknowledgments xvii Section 1 Introduction to Biosensors, Recognition Elements, Biomarkers, and Nanomaterials 1 1 General Introduction to Biosensors and Recognition Receptors 3Frank Davis and Zeynep Altintas 1.1 Introduction to Biosensors 3 1.2 Enzyme- Based Biosensors 4 1.3 DNA- and RNA-Based Biosensors 5 1.4 Antibody-Based Biosensors 7 1.5 Aptasensors 8 1.6 Peptide-Based Biosensors 10 1.7 MIP-Based Biosensor 11 1.8 Conclusions 12 References 13 2 Biomarkers in Health Care 17Adama Marie Sesay, Pirkko Tervo, and Elisa Tikkanen 2.1 Introduction 17 2.2 Biomarkers 18 2.2.1 Advantage and Utilization of Biomarkers 18 2.2.2 Ideal Characteristics of Biomarkers 19 2.3 Biological Samples and Biomarkers 20 2.4 Personalized Health and Point-of-Care Technology 22 2.5 Use of Biomarkers in Biosensing Technology 24 2.6 Biomarkers in Disease Diagnosis 26 2.7 Conclusions 29 References 30 3 The Use of Nanomaterials and Microfluidics in Medical Diagnostics 35Jon Ashley and Yi Sun 3.1 Introduction 35 3.2 Nanomaterials in Medical Diagnostics (Bottom-Up Approach) 36 3.2.1 Carbon Nanomaterials 37 3.2.2 Metallic Nanoparticles 39 3.2.2.1 Quantum Dots 39 3.2.2.2 Magnetic Nanoparticles (Fe2O3, FeO, and Fe3O4) 41 3.2.2.3 Gold Nanoparticles 41 3.2.2.4 Silver Nanoparticles 42 3.2.2.5 Nanoshells 42 3.2.2.6 Nanocages 43 3.2.2.7 Nanowires 43 3.2.3 Polymer-Based Nanoparticles 44 3.3 Application of Microfluidic Devices in Clinical Diagnostics (Top-Down Approach) 45 3.3.1 Unique Features of Microfluidic Devices 45 3.3.2 Applications of Microfluidic Devices in Medical Diagnostics 46 3.3.2.1 Types of Microfluidic POC Devices 47 3.3.2.2 Benchtop Microfluidic Instruments 47 3.3.2.3 Small, Lightweight Microfluidic Devices 49 3.3.2.4 Simple Un-instrumented Microfluidic Systems 50 3.4 Integration of Microfluidics with Nanomaterials 52 3.5 Future Perspectives of Nanomaterial and Microfluidic-Based Diagnostics 53 References 54 Section 2 Biosensor Platforms for Disease Detection and Diagnostics 59 4 SPR-Based Biosensor Technologies in Disease Detection and Diagnostics 61Zeynep Altintas and Wellington M. Fakanya 4.1 Introduction 61 4.2 Basic Theoretical Principles 63 4.3 SPR Applications in Disease Detection and Diagnostics 66 4.3.1 SPR Biosensors in Cancer Detection 66 4.3.2 SPR Sensors in Cardiac Disease Detection 68 4.3.3 SPR Sensors in Infectious Disease Detection 71 4.4 Conclusions 72 References 74 5 Piezoelectric-Based Biosensor Technologies in Disease Detection and Diagnostics 77Zeynep Altintas and Noor Azlina Masdor 5.1 Introduction 77 5.2 QCM Biosensors 78 5.3 Disease Diagnosis Using QCM Biosensors 80 5.3.1 Cancer Detection Using QCM Biosensors 82 5.3.2 Cardiovascular System Disorder Detection Using Biosensors 85 5.3.3 Pathogenic Disease Detection Using QCM Biosensors 88 5.4 Conclusions 90 References 91 6 Electrochemical-Based Biosensor Technologies in Disease Detection and Diagnostics 95Andrea Ravalli and Giovanna Marrazza 6.1 Introduction 95 6.2 Electrochemical Biosensors: Definitions, Principles, and Classifications 96 6.3 Biomarkers in Clinical Applications 102 6.3.1 Electrochemical Biosensors for Tumor Markers 102 6.3.2 Electrochemical Biosensors for Cardiac Markers 110 6.3.3 Electrochemical Biosensors for Autoimmune Disease 115 6.3.4 Electrochemical Biosensors for Autoimmune Infectious Disease 116 6.4 Conclusions 118 References 118 7 MEMS-Based Cell Counting Methods 125Mustafa Kangul, Eren Aydin, Furkan Gokce, Ozge Zorlu, Ebru Ozgur, and Haluk Kulah 7.1 Introduction 125 7.2 MEMS-Based Cell Counting Methods 126 7.2.1 Optical Cell Counting Methods 126 7.2.1.1 Quantification of the Cells by Detecting Luminescence 127 7.2.1.2 Quantification of the Cells via High-Resolution Imaging Techniques 130 7.3 Electrical and Electrochemical Cell Counting Methods 131 7.3.1 Impedimetric Cell Quantification 133 7.3.2 Voltammetric and Amperometric Cell Quantification 135 7.4 Gravimetric Cell Counting Methods 136 7.4.1 Deflection-Based Cell Quantification 136 7.4.2 Resonant-Based Cell Quantification 138 7.4.2.1 Theory of the Resonant-Based Sensors 138 7.4.2.2 Actuation and Sensing Methods of Resonators in MEMS Applications 140 7.4.2.3 Resonator Structure Types Used for Cell Detection Applications 145 7.5 Conclusion and Comments 149 References 151 8 Lab-on-a-Chip Platforms for Disease Detection and Diagnosis 155Ziya Isiksacan, Mustafa Tahsin Guler, Ali Kalantarifard, Mohammad Asghari, and Caglar Elbuken 8.1 Introduction 155 8.2 Continuous Flow Platforms 156 8.3 Paper-Based LOC Platforms 161 8.4 Droplet-Based LOC Platforms 166 8.5 Digital Microfluidic-Based LOC Platforms 169 8.6 CD-Based LOC Platforms 172 8.7 Wearable LOC Platforms 174 8.8 Conclusion and Outlook 176 References 177 Section 3 Nanomaterial's Applications in Biosensors and Diagnostics 183 9 Applications of Quantum Dots in Biosensors and Diagnostics 185Zeynep Altintas, Frank Davis, and Frieder W. Scheller 9.1 Introduction 185 9.2 Quantum Dots: Optical Properties, Synthesis, and Surface Chemistry 186 9.3 Biosensor Applications of QDs 187 9.4 Other Biological Applications of QDs 191 9.5 Water Solubility and Cytotoxicity 194 9.6 Conclusion 196 References 197 10 Applications of Molecularly Imprinted Nanostructures in Biosensors and Diagnostics 201Deniz Aktas-Uygun, Murat Uygun, and Sinan Akgol 10.1 Introduction 201 10.2 Molecular Imprinted Polymers 202 10.3 Imprinting Approaches 204 10.4 Molecularly Imprinted Nanostructures 205 10.5 MIP Biosensors in Medical Diagnosis 207 10.6 Diagnostic Applications of MIP Nanostructures 210 10.7 Conclusions 212 References 213 11 Smart Nanomaterials: Applications in Biosensors and Diagnostics 219Frank Davis, Flavio M. Shimizu, and Zeynep Altintas 11.1 Introduction 219 11.2 Metal Nanoparticles 221 11.3 Magnetic Nanoparticles 226 11.4 Carbon Nanotubes 231 11.5 Graphene 235 11.6 Nanostructured Metal Oxides 242 11.7 Nanostructured Hydrogels 247 11.8 Nanostructured Conducting Polymers 254 11.9 Conclusions and Future Trends 260 References 262 12 Applications of Magnetic Nanomaterials in Biosensors and Diagnostics 277Zeynep Altintas 12.1 Introduction 277 12.2 MNP-Based Biosensors for Disease Detection 279 12.3 MNPs in Cancer Diagnosis and Therapy 284 12.4 Cellular Applications of MNPs in Biosensing, Imaging, and Therapy 289 12.5 Conclusions 290 References 291 13 Graphene Applications in Biosensors and Diagnostics 297Adina Arvinte and Adama Marie Sesay 13.1 Introduction 297 13.2 Graphene and Biosensors 298 13.2.1 Structure 298 13.2.2 Preparation 299 13.2.3 Properties 301 13.2.4 Commercialization in the Field of Graphene Sensors 302 13.2.5 Latest Developments in Graphene-based Diagnosis 303 13.3 Medical Applications of Graphene 303 13.3.1 Electrochemical Graphene Biosensors for Medical Diagnostics 304 13.3.1.1 Glucose Detection 304 13.3.1.2 Cysteine Detection 307 13.3.1.3 Cholesterol Detection 309 13.3.1.4 Hydrogen Peroxide (H2O2) 310 13.3.1.5 Glycated Hemoglobin 312 13.3.1.6 Neurotransmitters 312 13.3.1.7 Amyloid-Beta Peptide 315 13.3.2 Electrochemical Graphene Aptasensors 316 13.3.2.1 Nucleic Acids 316 13.3.2.2 Cancer Cell 318 13.3.3 Optical Graphene Sensors for Medical Diagnostics 319 13.4 Conclusions 322 Acknowledgments 322 References 322 Section 4 Organ-Specific Health Care Applications for Disease Cases Using Biosensors 327 14 Optical Biosensors and Applications to Drug Discovery for Cancer Cases 329Zeynep Altintas 14.1 Introduction 329 14.2 Biosensor Technology and Coupling Chemistries 332 14.3 Optical Biosensors for Drug Discovery 335 14.4 Computational Simulations and New Approaches for Drug-Receptor Interactions 341 14.5 Conclusions 343 References 344 15 Biosensors for Detection of Anticancer Drug-DNA Interactions 349Arzum Erdem, Ece Eksin, and Ece Kesici 15.1 Introduction 349 15.2 Electrochemical Techniques 351 15.3 Optical Techniques 356 15.4 Electrochemical Impedance Spectroscopy Technique 358 15.5 QCM Technique 360 15.6 Conclusions 361 Acknowledgments 361 References 361 Index.
  • (source: Nielsen Book Data)9781119065012 20171204
Provides a broad range of information from basic principles to advanced applications of biosensors and nanomaterials in health care diagnostics This book utilizes a multidisciplinary approach to provide a wide range of information on biosensors and the impact of nanotechnology on the development of biosensors for health care. It offers a solid background on biosensors, recognition receptors, biomarkers, and disease diagnostics. An overview of biosensor-based health care applications is addressed. Nanomaterial applications in biosensors and diagnostics are included, covering the application of nanoparticles, magnetic nanomaterials, quantum dots, carbon nanotubes, graphene, and molecularly imprinted nanostructures. The topic of organ-specific health care systems utilizing biosensors is also incorporated to provide deep insight into the very recent advances in disease diagnostics. Biosensors and Nanotechnology: Applications in Health Care Diagnostics is comprised of 15 chapters that are presented in four sections and written by 33 researchers who are actively working in Germany, the United Kingdom, Italy, Turkey, Denmark, Finland, Romania, Malaysia and Brazil. It covers biomarkers in healthcare; microfluidics in medical diagnostics; SPR-based biosensor techniques; piezoelectric-based biosensor technologies; MEMS-based cell counting methods; lab-on-chip platforms; optical applications for cancer cases; and more. Discusses the latest technology and advances in the field of biosensors and their applications for healthcare diagnosticsParticular focus on biosensors for cancerSummarizes research of the last 30 years, relating it to state-of-the-art technologies Biosensors and Nanotechnology: Applications in Health Care Diagnostics is an excellent book for researchers, scientists, regulators, consultants, and engineers in the field, as well as for graduate students studying the subject.
(source: Nielsen Book Data)9781119065012 20171204
Book
xxxi, 312 pages : illustrations ; 23 cm
Green Library
Book
xii, 333 pages : illustrations ; 25 cm.
  • Introduction - Brain Waves Then and Now Electrifying Brain Images Hans Berger's Long Path to the EEG Current in the Head Research Strategies of a Conservative Psychiatrist The Measure of Psychic Energy The Course to Current Amplified Oscillations Artefacts and Noise Invitation to Stockholm Electrotechniques of the Live Mind Cultural Currents 1918-1933 The Bioengineer and Psychodiagnostics Nerve Apparatus and Psychic Circuits Thought Rays and Radio-Telepathy Configurations of Electrotherapy in the Radio Age Poetics of New Objectivity in Brain Script The Experimentalization of Daily Life Terra nova: Contexts of Electroencephalographic Explorations Epistemic Resonances and Material Cultures Berger's Further Voyage through Brain Waves Local Appointment in Buch near Berlin Acknowledgment with British Understatement The Leap over the Pond The Matrix of the Waves Set to and Survey Much! On the Cultural Practice of a New Technology Dynamics of Standardization A Diagnostic Panopticon Under the Shock Spell The Electrical Brain at Auschwitz Designing, Tinkering, Thinking What's Hidden inside the EEG? Rapid Vibrations of Thought The Concert of Cerebral Currents A German Physiologist's Lofty Flights The Brain as a Cybernetic Machine Brain Theories out of the Model Building-Block Box Conclusion - Plea for an Open Epistemology.
  • (source: Nielsen Book Data)9781472469441 20180319
In the history of brain research, the prospect of visualizing brain processes has continually awakened great expectations. In this study, Cornelius Borck focuses on a recording technique developed by the German physiologist Hans Berger to register electric brain currents; a technique that was expected to allow the brain to write in its own language, and which would reveal the way the brain worked. Borck traces the numerous contradictory interpretations of electroencephalography, from Berger's experiments and his publication of the first human EEG in 1929, to its international proliferation and consolidation as a clinical diagnostic method in the mid-twentieth century. Borck's thesis is that the language of the brain takes on specific contours depending on the local investigative cultures, from whose conflicting views emerged a new scientific object: the electric brain.
(source: Nielsen Book Data)9781472469441 20180319
Green Library
Book
1 online resource (xxi, 1714 pages) : illustrations (chiefly color)
  • Section 1: History of the Therapy of Breast Cancer 1. History of the Therapy of Breast Cancer Section 2: Anatomy and Physiology of the Normal and Lactating Breast 2. Anatomy of the Breast, Axilla, Chest Wall, and Related Metastatic Sites 3. Breast Physiology: Normal and Abnormal Development and Function 4. Discharges and Secretions of the Nipple Section 3: Benign and Premalignant Lesions 5. Etiology and Management of Benign Breast Disease 6. Mastitis and Breast Abscess 7. Gynecomastia 8. Benign, High-Risk, and Premalignant Lesions of the Breast Section 4: Pathology of Malignant Lesions 9. In Situ Carcinomas of the Breast: Ductal Carcinoma in Situ and Lobular Carcinoma in Situ 10. Infiltrating Carcinomas of the Breast: Not One Disease 11. Mesenchymal Neoplasms and Primary Lymphomas of the Breast 12. Paget Disease of the Breast 13. Primary and Secondary Dermatologic Disorders of the Breast 14. Breast Biomarker Immunocytochemistry Section 5: Natural History, Epidemiology, Genetics, and Syndromes of Breast Cancer 15. Epidemiology of Breast Cancer 16. Primary Prevention of Breast Cancer 17. Breast Cancer Genetics: Syndromes, Genes, Pathology, Counseling, Testing, and Treatment Section 6: Prognostic Factors for Breast Cancer 18. Clinically Established Prognostic Factors in Breast Cancer 19. Molecular Prognostic Factors for Breast Carcinoma 20. Risk Factors for Breast Carcinoma in Women with Proliferative Breast Disease 21. Steroid Receptors in Breast Cancer Section 7: Molecular Biology of Breast Carcinogenesis 22. Molecular Oncology of Breast Cancer 23. Stem Cells in Breast Development and Cancer 24. Therapeutic Strategies for Breast Cancer Section 8: Screening and Diagnosis of Breast Disease 25. Examination Techniques: Roles of the Physician and Patient in Evaluating Breast Disease 26. Breast Imaging Screening and Diagnosis Section 9: Clinical Trials: Biostatistical Applications 27. Design and Conduct of Clinical Trials for Breast Cancer Section 10: Surgery for Benign and Malignant Diseases of the Breast 28. Indications and Techniques for Biopsy 29. General Principles of Mastectomy: Evaluation and Therapeutic Options 30. Halsted Radical Mastectomy 31. Modified Radical Mastectomy and Simple Mastectomy 32. Breast Conservation Therapy for Invasive Breast Cancer Section 11: Breast Reconstruction 33. Breast Reconstruction Techniques Section 12: Complications of Breast Surgery 34. Wound Care and Complications of Mastectomy 35. Quality Measures and Outcomes for Breast Cancer Surgery 36. Lymphedema in the Postmastectomy Patient: Pathophysiology, Prevention, and Management Section 13: Current Concepts and Management of Early Breast Carcinoma (Tis, Tmic, T1) 37. Assessment and Designation of Breast Cancer Stage 38. Biology and Management of Lobular Carcinoma in Situ of the Breast (Lobular Neoplasia) 39. Ductal Carcinoma in Situ 40. The New Paradigm: Oncoplastic Breast Conservation Surgery 41. Therapeutic Value of Axillary Node Dissection and Selective Management of the Axilla in Small Breast Cancers 42. Lymphatic Mapping and Sentinel Lymphadenectomy for Breast Cancer 43. Detection and Significance of Axillary Lymph Node Micrometastases 44. Intraoperative Evaluation of Surgical Margins in Breast-Conserving Therapy 45. Surgical Management of Early Breast Cancer Section 14: Therapy for Stages 0, I, and II Breast Cancer 46. Biologic Basis of Radiotherapy of the Breast 47. Radiotherapy and Ductal Carcinoma in Situ 48. Radiotherapy and Regional Nodes 49. Postmastectomy Radiotherapy 50. Breast-Conserving Therapy for Invasive Breast Cancers 51. Partial Breast Irradiation: Accelerated and Intraoperative 52. Radiation Complications and Their Management 53. Radiation Therapy for Locally Advanced Breast Cancer: Historical Review to Current Approach 54. Adjuvant Endocrine Therapy 55. Adjuvant and Neoadjuvant Systemic Therapies for Early Stage Breast Cancer 56. Adjuvant HER2 Therapy 57. Bisphosphonates in Early Breast Cancer 58. Oncofertility Options for Young Women with Breast Cancer Section 15: Management of Advanced Local, Regional, and Systemic Disease 59. Surgical Procedures for Advanced Local and Regional Malignancies of the Breast 60. Solitary Metastases 61. Locoregional Recurrence after Mastectomy 62. Principles of Preoperative Therapy for Operable Breast Cancer 63. Locally Advanced Breast Cancer 64. Inflammatory Breast Cancer 65. Neoadjuvant Chemotherapy and Radiotherapy 66. Detection and Clinical Implications of Occult Systemic Micrometastatic Breast Cancer 67. Management of the Intact Breast Primary in the Setting of Metastatic Disease 68. Management of Bone Metastases in Breast Cancer 69. Chemotherapy and HER2-Directed Therapy for Metastatic Breast Cancer 70. Endocrine Therapy for Breast Cancer 71. Immunologic Approaches to Breast Cancer Therapy 72. Diagnosis and Management of Pleural Metastases in Breast Cancer 73. Management of Central Nervous System Metastases in Breast Cancer 74. Management of Pericardial Metastases in Breast Cancer Section 16: Special Presentations of Breast Cancer 75. Bilateral Breast Cancer 76. Cancer of the Male Breast 77. Local Recurrence, the Augmented Breast, and the Contralateral Breast 78. Carcinoma of the Breast in Pregnancy and Lactation 79. Unknown Primary Presenting with Axillary Lymphadenopathy 80. Clinical Management of the Patient at Increased or High Risk Section 17: Survivorship, Follow-Up Care, and Rehabilitation of the Breast Cancer Patient 81. General Considerations for Follow-Up 82. Management of Menopause in the Breast Cancer Patient 83. Rehabilitation 84. Psychosocial Consequences and Lifestyle Interventions 85. Survivorship with Breast Cancer Section 18: Medical and Legal Issues Specific to the Care of Breast Cancer 86. Delayed Diagnosis of Symptomatic Breast Cancer.
  • (source: Nielsen Book Data)9780323359559 20171017
Now in a single, convenient volume, The Breast: Comprehensive Management of Benign and Malignant Diseases, 5th Edition covers every clinically relevant aspect of the field: cancer, congenital abnormalities, hormones, reconstruction, anatomy and physiology, benign breast disease, and more. Building upon the strengths of previous editions, this updated volume by Drs. Kirby I. Bland, Edward M. Copeland III, V. Suzanne Klimberg, and William J Gradishar, includes the latest innovations in breast cancer detection and treatment in a practical, easy-to-use format ideal for today's surgeons.Delivers step-by-step clinical guidance highlighted by superb illustrations that depict relevant anatomy and pathology, as well as medical and surgical procedures. Reflects the collaborative nature of diagnosis and treatment among radiologists, pathologists, surgeons, oncologists, and other health care professionals who contribute to the management of patients with breast disease. Offers the most comprehensive, up-to-date information on the diagnosis and management of, and rehabilitation following, surgery for benign and malignant diseases of the breast. Covers the latest developments in receptor modulation, targeted monoclonal antibodies, evolving inhibitors with triple-negative disease, and more. Discusses recent minimally invasive surgical techniques and new developments in oncoplastic breast conservation techniques. Contains significant updates to the "Management of Systemic Disease" section that reflect the latest advances in chemotherapy, hormonal resistance, and therapy. Includes links to real-time procedure videos and full-color procedural line drawings from the Klimberg Atlas of Breast Surgical Techniques on Expert Consult, providing expert visual guidance on how to execute key steps and techniques. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.
(source: Nielsen Book Data)9780323359559 20171017
Book
xi, 241 pages : illustrations ; 24 cm.
Breast cancer is now the most common cancer among women in most Asian countries. Many lives are at stake. Even in places where state-of-the-art medical services are available, thousands of women in Asia are dying of the disease largely due to late presentation compared to women in most Western countries. While much progress has been made in Western medical science to treat breast cancer, it appears that there are significant socio-cultural considerations and contexts in Asia that limit the efficacy of Western-based health-care methods. This volume presents conversations across Asia with breast cancer patients, their caregivers, doctors, traditional healers as well as just ordinary men and women - all on the subject of breast cancer meanings. Through the stories as told by local peoples in Asia about how they think and talk about breast cancer, as well as how they respond to the disease, insights on breast cancer meanings emerge. These offer new understandings into how local contexts shape those meanings and life courses - and hopefully will help medical practitioners devise new strategies to combat the disease.
(source: Nielsen Book Data)9788776942427 20180430
Green Library
Book
1 online resource.
  • 1. The History of the Brugada Phenocopy concept 2. Brugada Phenocopy: Definition, systematic approach to its diagnosis, how to differentiate it from true Brugada Syndrome 3. The value of the sodium channel blocker test in Brugada syndrome and Brugada Phenocopy: Pieter Postema (The Netherlands) 4. How to recognize a Brugada ECG pattern: The beta angle 5. How to recognize a Brugada ECG pattern: The base of the triangle 6. The Rsr' pattern in leads V1-V2: algorithm and differential diagnosis 7. International Registry & Educational Portal on Brugada Phenocopies 8. Specific Brugada Phenocopies: Ischemia 9. Specific Brugada Phenocopies: Acute pulmonary embolism 10. Specific Brugada Phenocopies: Electrolyte disorders 11. The ECG of the athlete & the differential diagnosis with the Brugada ECG pattern 12. The value of the Vectorcardiogram in Brugada syndrome 13. How to apply the beta angle and base of the triangle in real cases 14. Exceptional Brugada Phenocopies 15. The importance of Brugada Phenocopy 16. The importance of risk stratifying in Brugada syndrome 17. Differentiation between BrS ECG pattern and BrP ECG pattern: Is this possible? 18. The Journey of describing a new ECG phenomenon.
  • (source: Nielsen Book Data)9780128111512 20180514
Brugada Phenocopy: The Art of Recognizing the Brugada ECG Pattern details all aspects associated with alternative diagnosis to Brugada Syndrome (BrS). Coverage includes how to identify the proper ECG pattern, what to do to investigate for BrP, and how to avoid misinterpretations and the use of unnecessary and expensive treatments. Chapters are written by experienced professionals, many of whom are colleagues that initially described this condition. This easy to use volume is a must have reference for researchers of cardiology, cardiologists, electrocardiologists, internists, emergency care doctors and students, residents and fellows.
(source: Nielsen Book Data)9780128111512 20180514