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1 online resource.
  • 1. A Healthy Diet for Your Heart and Your Brain 2. Dietary Patterns 3. Epidemiological and Nutritional Methods 4. Not All Fats are Unhealthy 5. Virgin Olive Oil: A Mediterranean Diet Essential 6. A Small Handful of Mixed Nuts 7. Fruits and Vegetables 8. Cereals and Legumes: Provides a High Quality Source of Proteins and Fiber 9. More Fish, Less Meat 10. Red Wine Moderate Consumption and at Mealtimes 11. The Mediterranean Life Style: Not Only Diet But Also Socializing and Physical Activity 12. The Mediterranean Cook: Recipes for All Seasons.
  • (source: Nielsen Book Data)9780128112595 20171017
The Prevention of Cardiovascular Disease through the Mediterranean Diet presents dietary habits that will have maximum impact on cardiovascular health and other major chronic diseases. Data collected through the results of large clinical trials, such as PREDIMED, one of the longest trials ever conducted, has allowed researchers to conclude that the Mediterranean Diet provides the best evidence for health benefits. Studies have shown that the Mediterranean Diet is able to reduce the risk of cardiovascular hard clinical events by 30%. This book explores the components of this diet, including the consumption of extra virgin olive oil, nuts, fresh fruits and vegetables, fatty fish, poultry and red wine for optimal health benefits.
(source: Nielsen Book Data)9780128112595 20171017

22. Pulmonary pathology [2018]

1 online resource (xiv, 759 pages) : color illustrations
  • 1. Normal Anatomy, Tissue Artifacts, and Incidental Structures 2. The Uses and Abuses of the Lung Biopsy 3. A Pattern-Based Approach to Diagnosis 4. Congenital, Developmental, and Inherited Disorders 5. Acquired and Idiopathic Disorders in Neonates and Young Children 6. Lung Neoplasms in Infants and Children 7. Vascular Diseases 8. Vasculitides and Other Causes of Pulmonary Hemorrhage 9. Acute Lung Injury 10. Bacterial Diseases 11. Mycobacterial Diseases 12. Fungal Diseases 13. Viral Diseases 14 Human Parasitic Pulmonary Infections 15 Chlamydial, Mycoplasmal, Rickettsial, and Ehrlichial Diseases 16. Idiopathic Interstitial Pneumonias 17. Other Interstitial Lung Diseases 18. Environmental- and Toxin-Induced Lung Diseases 19. Drug Reactions and Other Iatrogenic Pulmonary Diseases 20. Emphysema and Diseases of Large Airways 21. Diseases of Small Airways 22. Lymphoid Lesions of the Lung 23. Uncommon Histiocytic and Dendritic Cell Proliferations 24. Transplantation-Related Lung Pathology 25. Other Non-Neoplastic Focal Lesions, Inclusions, and Depositions.
  • (source: Nielsen Book Data)9780323393089 20170410
Now fully revised to include recent advances in the field, the second edition of Pulmonary Pathology, a volume in the Foundations in Diagnostic Pathology series, is an essential foundation text for residents and pathologists. The popular template format makes it easy to use, and new information throughout brings you up to date with what's new in pulmonary pathology and pulmonary medicine, including molecular genetics and personalized medicine therapies. Practical and affordable, this resource by Drs. Dani S. Zander and Carol F. Farver is ideal for study and review as well as everyday clinical practice.
(source: Nielsen Book Data)9780323393089 20170410
1 online resource (xv, 219 pages) : illustrations (some color).
  • Title Page; Copyright; Dedication; Table of Contents; List of Contributors; Acknowledgements; Introduction; Chapter 1: Subtotal Nephrectomy and Tumour Ablation; Introduction; Procedures; Conclusions; References; Chapter 2: Renal Transplantation; Introduction; The Role of Ultrasound Imaging; Vascular Complications; Urological Complications; Conclusions; References; Chapter 3: Imaging After Endo-urological Stone Treatment; Introduction; The Procedures; Ureteric Stones: Results and Complications; Renal Stones: Results and Complications; Complications and Follow-up; References
  • Chapter 4: Pelvi-ureteric Junction ReconstructionIntroduction; Antenatal Hydronephrosis; Pathophysiological Effect of True Pelvi-ureteric Obstruction; Physiological and Anatomical Changes in the Kidney Following Pyeloplasty; Incidental PUJO in adults; Long-term Follow-up; Conclusions; References; Chapter 5: Retroperitoneal Fibrosis; Introduction; Available Treatments; Follow-up; Complications; Long-term Follow-up; References; Chapter 6: Urinary Diversion; Introduction; The Procedures; Postoperative Imaging; Monitoring of Asymptomatic Patients; Management of Bacteriuria and Sepsis; References
  • Chapter 7: Ureteric Reconstruction and ReplacementIntroduction; Procedures; Clinical Follow-up and Complications; References; Chapter 8: Conservative and Reconstructive Bladder Surgery; Introduction; Extravasation; Bladder Perforation; Reconstruction Following Ureteric Injury and Partial Cystectomy; The Irradiated Bladder; Complications After Posterior Exenteration; Conclusions; References; Chapter 9: Bladder Augmentation in Children; Introduction; The Procedures; Clinical Follow-up; Postoperative Imaging; Complications of Enterocystoplasty; Unique Complications of Gastrocystoplasty
  • Changes Over TimeReferences; Chapter 10: Radiology and Follow-up of the Neobladder; Introduction; The Procedure; The Neobladder; Postoperative Imaging; Clinical Follow-up; Oncologic Follow-up Specific to the Neobladder; Secondary Tumour Growth in Urinary Diversions for Benign Disease (see also Chapter 11); Complications; Changes Over Time; References; Chapter 11: General Consequences of Lower Urinary Tract Replacement and Reconstruction; Introduction; Reservoirs; Urodynamic Findings; Stones; Renal Function; Perforation; Histological Changes; Infection; Neoplasia; Urine Testing for Pregnancy
  • The Conduit and ContinenceReferences; Chapter 12: Surgery on the Benign Prostate; Introduction; Procedures; Outcomes and Complications; Changes Over Time; References; Chapter 13: Imaging After Treatment of Prostate Cancer; Introduction; Appearances After Radical Prostatectomy; Residual Tumour After Radical Prostatectomy; The Prostate After Ablative Therapies; References; Chapter 14: Urethroplasty; Introduction; Pericatheter Urethrogram; Ascending and Descending Urethrography; References; Chapter 15: The Postoperative Appearance and Follow-up of Urinary Tract Prostheses; Introduction
1 online resource : color illustrations
  • Sedation in dentistry: a historic perspective
  • Pain and anxiety in dentistry
  • Introduction to sedation
  • The spectrum of pain and anxiety control
  • Physical and psychological evaluation
  • Monitoring during sedation
  • Nondrug techniques : iatrosedation and hypnosis
  • Oral sedation
  • Rectal sedation
  • Sublingual, transdermal, and intranasal sedation
  • Intramuscular sedation
  • Inhalation sedation : historical perspective
  • Inhalation sedation : rationale
  • Pharmacology, anatomy, and physiology
  • Inhalation sedation equipment
  • Inhalation sedation : techniques of administration
  • Inhalation sedation : complications
  • Contemporary issues surrounding nitrous oxide
  • Practical considerations
  • Teaching inhalation sedation : history and present guidelines
  • Intravenous sedation : historical perspective
  • Intravenous moderate sedation : rationale
  • Armamentarium
  • Anatomy for venipuncture
  • Venipuncture technique
  • Pharmacology
  • Intravenous moderate sedation : techniques of administration
  • Intravenous sedation : complications
  • Practical considerations
  • Guidelines for teaching
  • Fundamentals of general anesthesia
  • Armamentarium, drugs, and techniques
  • Preparation for emergencies
  • Emergency drugs and equipment
  • Management of emergencies
  • The pediatric patient
  • The geriatric patient
  • The medically compromised patient
  • The physically compromised patient
  • Neurologic illnesses and other conditions
  • Medicolegal considerations
  • The controversial development of anesthesiology in dentistry.
"Learn how to safely sedate your dental patients and help control their anxiety with Sedation: A Guide to Patient Management, 6th Edition. Written by sedation expert Stanley Malamed, DDS, this concise guide combines essential theory with "how-to" technical instruction to help you master basic techniques in dental sedation and anxiety control. This new sixth edition also incorporates the latest guidelines from the ADA and the American Society of Anesthesiologists, along with vivid images of the most current equipment and procedures used in dental practice today. There is also detailed discussion on how to modify typical treatment protocol to successfully treat different patient populations - including pediatric, geriatric, physically compromised, and medically compromised patients. In all, this is a must-have guide for keeping up to date on the latest techniques in dental sedation and anxiety"--Publisher's description.
xvii, 198 pages : illustrations (some color) ; 22 cm
  • Part I: Sex Selection.- Chapter 1 Coping with Sex Selective Abortions in Vietnam: An Ethnographic Study of Selective Reproduction as Emotional Experience.- Chapter 2 The Development of Sex Selective Reproductive Technologies within Fertility, Inc. and the Anticipation of Lifestyle Sex Selection.- Part II: Preventing Disease and Disability.- Chapter 3 Moral Adherers: Pregnant Women Undergoing Routine Prenatal Screening in Denmark.- Chapter 4 Moral Bearing: The Paradox of Choice, Anxiety and Responsibility in Taiwan.- Chapter 5 Selecting What? Pre-implantation Genetic Diagnosis and Screening Trajectories in Spain.- Part III: Selecting Traits.- Chapter 6 They Don't Just Take a Random Egg: Egg Selection in the United States.- Chapter 7 Technologies of Enchantment: Commercial Surrogacy and Egg Donation in India.
  • (source: Nielsen Book Data)9783319582191 20171017
This book explores how conditions for childbearing are changing in the 21st century under the impact of new biomedical technologies. Selective reproductive technologies (SRTs) - technologies that aim to prevent or promote the birth of particular kinds of children - are increasingly widespread across the globe. Wahlberg and Gammeltoft bring together a collection of essays providing unique ethnographic insights on how SRTs are made available within different cultural, socio-economic and regulatory settings and how people perceive and make use of these new possibilities as they envision and try to form their future lives. Topics covered include sex-selective abortions, termination of pregnancies following detection of fetal anomalies during prenatal screening, the development of preimplantation genetic diagnosis techniques as well as the screening of potential gamete donors by egg agencies and sperm banks. This is invaluable reading for scholars of medical anthropology, medical sociology and science and technology studies, as well as for the fields of gender studies, reproductive health and genetic disease research.
(source: Nielsen Book Data)9783319582191 20171017
Green Library
1 online resource (384 pages)
  • (source: Nielsen Book Data)9780323480420 20170911
A highly clinical focus and clear, vibrant illustrations make Textbook of Clinical Hemodynamics, 2nd Edition, by Dr. Michael Ragosta, the resource of choice for accurately analyzing hemodynamic waveforms generated in cardiac catheterization labs. This easy-to-use, disease-oriented reference-ideal for physicians, nurses, and technicians-offers the unparalleled detail and visual support you need for interpreting the findings you encounter in practice. New coverage throughout keeps everyone on the cardiac team up to date with the latest concepts and skills, ensuring more effective monitoring and treatment of patients with cardiac disease.
(source: Nielsen Book Data)9780323480420 20170911
1 online resource.
  • Introduction to the Handbook. A Framework for the Handbook's Exploration of Disruptive Behavior Disorders, Intermittent Explosive Disorder, and Impulse-Control Disorders / John E Lochman, Walter Matthys
  • Diagnostic Issues for the Disruptive and Impulse-Control Disorders. Diagnostic Issues in Oppositional Defiant Disorder / Jeffrey D Burke, Olivia J Derella, Oliver G Johnston
  • Conduct Disorder and Callous-Unemotional Traits / Paul J Frick, Tina D Wall Myers
  • Diagnostic Issues for ODD/CD with ADHD Comorbidity / Kristen L Hudec, Amori Yee Mikami
  • Comorbidity with Substance Abuse / Naomi R Marmorstein, Helene R White
  • Intermittent Explosive Disorder and the Impulse-Control Disorders / Emil F Coccaro, Jon E Grant
  • Related Personality Disorders Located within an Elaborated Externalizing Psychopathology Spectrum / Martin Sellbom Bo Bach, Elizabeth Huxley
  • Etiological and Maintenance Factors. Genetic and Gene-Environment Influences on Disruptive Behavior Disorders / Edward D Barker, Charlotte A M Cecil, Esther Walton, Alan J Meehan
  • The Neurobiology of Oppositional Defiant Disorder and Conduct Disorder / Leah M Efferson, Andrea L Glenn
  • Cognitive Functions / Matthew A Jarrett, Dane C Hilton
  • Temperament / Jinhong Guo, Sylvie Mrug
  • Prenatal and Perinatal Risk Factors / D Anne Winiarski, Cassandra L Hendrix, Erica L Smearman, Patricia A Brennan
  • Attachment and Disruptive Disorders / Marleen G Groeneveld, Judi Mesman
  • Emotion Regulation / Megan K Bookhout, Julie A Hubbard, Christina C Moore
  • "It's Gonna End Up with a Fight Anyway" / Bram Orobio Castro, Anouk Dijk
  • Family Poverty and Structure / Barbara Maughan, Richard Rowe, Joseph Murray
  • Parent Psychopathology / Tammy D Barry, Rebecca A Lindsey, Elizabeth C Fair, Kristy M DiSabatino
  • Relationship Discord, Intimate Partner Physical Aggression, and Externalizing Problems of Children / K Daniel O'Leary, Ingrid Solano
  • Parenting Practices and the Development of Problem Behavior across the Lifespan / Elizabeth A Stormshak, Elisa DeVargas, Lucía E Cárdenas
  • Peer Rejection and Disruptive Behavioral Disorders / Kristina L McDonald, Carolyn E Gibson
  • The Role of Deviant Peers in Oppositional Defiant Disorder and Conduct Disorder / Damir S Utržan, Timothy F Piehler, Thomas J Dishion
  • The Broader Context / Paula J Fite, Sonia L Rubens, Spencer C Evans, Jonathan Poquiz
  • Assessment Processes. Problem-Solving Structure of Assessment / Walter Matthys, Nicole P Powell
  • Treatment and Prevention. Engaging Families in Treatment for Child Behavior Disorders / Mary Acri, Anil Chacko, Geetha Gopalan, Mary McKay
  • Pharmacotherapy of Disruptive and Impulse Control Disorders / Gloria M Reeves, Heidi J Wehring, Mark A Riddle
  • Psychosocial Treatment and Prevention of Conduct Problems in Early Childhood / Danielle Cornacchio, Laura J Bry, Amanda L Sanchez, Bridget Poznanski, Jonathan S Comer
  • Psychosocial Treatment and Prevention in Middle Childhood and Early Adolescence / Caroline L Boxmeyer, Nicole P Powell, Qshequilla Mitchell, Devon Romero, Cameron E Powe, Casey Dillon
  • Psychosocial Treatment and Prevention in the Adolescent Years for ODD and CD / Brian P Daly, David DeMatteo, Aimee Hildenbrand, Courtney N Baker, Jacqueline H Fisher
  • Factors Influencing Intervention Delivery and Outcomes / John E Lochman, Francesca Kassing, Meghann Sallee, Sara L Stromeyer
  • Concluding Comments. Future Directions / Walter Matthys, John E Lochman.
150 pages : illustrations ; 23 cm
  • Vorwort
  • Wichtige Abkürzungen
  • James Parkinson
  • Beschreibungen aus der Zeit vor James Parkinson
  • Der grosse Verdienst von James Parkinson
  • An Essay on the Shaking Palsy unter der Lupe
  • Das Leben von James Parkinson (1755-1824)
  • Jean-Martin Charcot
  • Die ersten Jahrzehnte nach Parkinsons Publikation
  • Charcots Beiträge
  • Das Leben von Jean-Martin Charcot (1825-1893)
  • Der Durchbruch lässt auf sich warten
  • Die erfolgreiche Suche nach einer Pathologie
  • Postenzephalitisches Parkinsonsyndrom
  • Untersuchungen zum Rigor
  • Das lange Warten auf eine wirksame Behandlung
  • Die Einführung von L-Dopa : ein therapeutischer Durchbruch
  • L-Dopa und Dopamin
  • Die ersten Therapieversuche am Patienten
  • Die Einführung in die Klinik
  • L-Dopa plus Dekarboxylasehemmer wird zum Goldstandard
  • COMT-Hemmer
  • Intestinale (jejunale) Infusion von L-Dopa plus Carbidopa
  • Andere wichtige Medikamente
  • Anticholinergika
  • Dopaminagonisten
  • Amantadin
  • MAO-B-Hemmer
  • Probleme der Langzeitbehandlung
  • Motorische Komplikationen
  • Psychische Komplikationen
  • Neurotoxizität und Neuroprotektion
  • Neurotoxine
  • Ist L-Dopa neurotoxisch?
  • Neuroprotektion
  • Hat die dopaminerge Behandlung die Lebenserwartung der Patienten verändert?
  • Renaissance der chirurgischen Behandlung
  • Tiefe Hirnstimulation (THS)
  • Zelltherapien
  • Neue Einsichten in das Krankheitsbild
  • Die Definitionen der Symptomatik ändern sich
  • Atypische Parkinsonsyndrome
  • Steht ein weiterer Durchbruch bevor?
  • Die Rolle von ... -Synuklein
  • Die Braak-Stadien
  • Entsteht das Krankheitsgeschehen im Magen-Darmtrakt?
  • Glossar
  • Literatur
  • Schlagwort- und Namenverzeichnis
  • Quellennachweis.
SAL3 (off-campus storage)
1 streaming video file (55 min.) : digital, sound, color
How the failure of key individuals, prominent NGO's, and governments to act allowed a catastrophe to fester - a catastrophe that undoubtedly could have been avoided. Since it appeared 20 years ago, AIDS has left behind it a trail of destruction. This film answers the question 'why did the world wait so long to react', and dissects the key moments in the global response to the epidemic. By examining this human catastrophe, the film reveals a global rift that helped the disease to spread.
1 streaming video file (25 min.) : digital, sound, color.
Lillian Cingo has one great luxury in her life -- a mini whirlpool to soak her sore feet. It's a small self-indulgence for a woman who spends all day on her feet, from dawn to dusk. Lillian's job is, literally, to keep her hospital on track. She's the manager of the Phelophepa health train that spends nine months each year touring the poorest, most remote areas of South Africa. This Life program catches up with the train in the province of KwaZulu Natal, where there's just one doctor for every 4,000 people. With a full contingent of volunteer doctors, dentists, optometrists and health educators on board, the 'Good Clean Health Train' delivers quality health care to deprived rural communities.
xxvi, 491 pages : illustrations ; 26 cm
  • (source: Nielsen Book Data)9780198727224 20161213
The central problem in the study of addiction is to explain why people repeatedly behave in ways they know are bad for them. For much of the previous century and until the present day, the majority of scientific and medical attempts to solve this problem were couched in terms of involuntary behavior; if people behave in ways they do not want, then this must be because the behavior is beyond their control and outside the realm of choice. An opposing tradition, which finds current support among scientists and scholars as well as members of the general public, is that so-called addictive behavior reflects an ordinary choice just like any other and that the concept of addiction is a myth. The editors and authors of this book tend to take neither view. There has been an increasing recognition in recent literature on addiction that restricting possible conceptions of it to either of these extreme positions is unhelpful and is retarding progress on understanding the nature of addiction and what could be done about it. This book contains a range of views from philosophy, neuroscience, psychiatry, psychology and the law on what exactly this middle ground between free choice and no choice consists of and what its implications are for theory, practice and policy on addiction. The result amounts to a profound change in our thinking on addiction and how its devastating consequences can be ameliorated. Addiction and Choice is a thought provoking new volume for all those with an interest in this global issue.
(source: Nielsen Book Data)9780198727224 20161213
Green Library
ix, 299 pages ; 21 cm
  • Preface
  • Introduction
  • The characteristics of children with attention-deficit hyperactivity disorder
  • The causes of attention-deficit hyperactivity disorder
  • The development of the child with attention-deficit hyperactivity disorder
  • Treatment of the child with attention-deficit hyperactivity disorder
  • Attention-deficit hyperactivity disorder in adults
  • Finding help
  • Appendix : diagnostic criteria : diagnosis of adhd in childhood and adulthood and related disorders
  • Index.
"Drawing on over forty years of clinical and research experience, Paul Wender and new coauthor David A. Tomb have created a classic, definitive model for identifying and treating children and adults who have Attention-Deficit Hyperactivity Disorder (ADHD). ADHD: Attention-Deficit Hyperactivity Disorder in Children and Adults, Fifth Edition offers insights into the progression of ADHD to those at any age and describes the best treatment. Wender and Tomb stress that drug therapy remains the most effective in treating the disorder, but psychological techniques, when combined with medication, can produce further improvement. In addition, extensive first-hand accounts from men, women, and children offer dramatic insight into what it feels like to have, and to receive medical treatment for, ADHD. Throughout, the book contains valuable information on where to seek help and what kinds of diagnostic tests exist and how reliable they are, as well as comprehensive instructions and rating scales to help parents best help their child and to help adults self-screen for the disorder. This concise and fully revised volume is a practical tool for individuals at any age, parents and teachers of children with ADHD, and clinicians."-- Provided by publisher.
"In a discussion of ADHD treatments, Wender and Tomb stress that drug therapy remains the most effective in treating the disorder. They add, however, that psychological techniques, when combined with medication, can produce further improvement. Wender and Tomb offer practical, comprehensive instructions on how parents of an ADHD sufferer can best help their child. Now a classic work, ADHD grants parents and adults whose lives have been touched by this disorder an indispensable source of help, hope, and understanding"-- Provided by publisher.
Green Library
1 online resource.
  • Front Cover; #x93; Advances in Ceramic Biomaterials#x93; ; Copyright Page; Contents; List of Contributors; Preface; Acknowledgments; I. An Overview of Biomedical Grade Ceramic Materials; 1 Materials for hard tissue applications: An overview; Chapter Outline; 1.1 Introduction: Hard tissues and how to replace them; 1.2 Materials for hard tissue applications; 1.2.1 Dental applications; Materials for dental implants; Materials for crowns and structures; Materials for esthetics; Materials for caries filling; 1.2.2 Orthopedic applications; Alumina
  • Zirconia (3Y-TZP) Composites; Materials in development; 1.2.3 Ceramics for bone repair; Sintered calcium orthophosphates; Bone cements; Bioactive glasses and glass ceramics; Ceramic-polymer composites; 1.3 Concluding remarks; References; 2 Types of ceramics: Material class; Chapter Outline; 2.1 Active oxides; 2.1.1 Introduction; 2.1.2 CaP-based systems; Pure and substituted HA and related apatite compounds; Well-crystallized apatites; Nanocrystalline apatites; Associations with other inorganic compounds
  • 2.5 Glass ceramics and bioactive glass ceramics2.6 Glass-ionomer cements; 2.6.1 Introduction; 2.6.2 The chemistry of GICs; 2.6.3 Glass compositions to form GICs; Aluminosilicate glasses; Aluminoborate glasses; Zinc silicate glasses; 2.6.4 Key factors affecting the properties of GICs; Al2O3/SiO2 ratio in the glass; Phosphorus content in the glass; F− content in the glass; Na+ content in the glass; Glass reactivity; Heat treatment; Acid washing; Particle size; 2.6.5 Fluoride release and recharge ability
  • 2.6.6 Antimicrobial effectiveness2.7 Magnetic ceramic materials in medicine; 2.8 Conclusion; References; Further reading; 3 Assessment of mechanical properties of ceramic materials; Chapter Outline; 3.1 Introduction to mechanical properties; 3.1.1 Bioceramics; 3.1.2 Fracture of ceramics; 3.1.3 Weibull statistics of the strength; 3.1.4 Subcritical crack growth; 3.1.5 KIC and curve R-behavior of ceramics; 3.1.6 Mechanisms of increase in fracture toughness; 3.2 Bioactive glasses and glass ceramics; 3.3 Calcium phosphates (CaP) and CaP composites; 3.4 Calcium phosphate cements
1 online resource.
  • List of contributors xiii Foreword xvii Preface xix 1 Introduction: An overview of malaria and Plasmodium 1 Virander S. Chauhan, Chetan E. Chitnis, and Deepak Gaur History 1 The life cycle of Plasmodium 3 A significant milestone in malaria research: Adaptation of Plasmodium to laboratory culture 4 The advent of present day technologies and their applications in malaria research 5 Bibliography 6 2 Exoerythrocytic development of Plasmodium parasites 9 Volker T. Heussler, Annika Rennenberg, and Rebecca R. Stanway The sporozoite s journey from the skin to the liver 10 Sporozoite invasion 14 Parasite development 15 Protein export from the parasite into the host cell 20 Parasite egress 23 The role of innate immune responses during merosome formation 26 Acknowledgments 27 Bibliography 27 3 Molecular basis of erythrocyte invasion by Plasmodium merozoites 33 Deepak Gaur, Chetan E. Chitnis, and Virander S. Chauhan The structure of the merozoite 39 The steps of erythrocyte invasion 41 Redundancy and ligand receptor interactions that mediate parasite adhesion during erythrocyte invasion 57 Signaling events during erythrocyte invasion by malaria parasites 74 Summary and conclusions 75 Bibliography 75 4 The biology of malaria transmission 87 Robert E. Sinden Purpose 87 History 87 The current research agenda 88 Biology 88 Population dynamics 106 Transmission blocking interventions 110 Bibliography 114 5 Comparative and functional genomics of malaria parasites 125 Martine M. Zilversmit, Sittiporn Pattaradilokrat, and Xin zhuan Su An Introduction to Plasmodium genomes 125 Genome structure of malaria parasites 127 From genome sequences to gene function 133 Summary 139 Acknowledgments 139 Bibliography 139 6 Gene regulation: New insights and possible intervention strategies 149 Artur Scherf, Nicholas A. Malmquist, Rafael M. Martins, Shruthi S. Vembar, and Jose Juan Lopez Rubio Introduction 149 Modes of gene regulation 150 Drug targeting 164 Perspectives 169 Bibliography 171 7 Molecular genetic approaches to malaria research 179 Brendan Elsworth, Mauro F. Azevedo, Brendan S. Crabb, and Paul R. Gilson Transfection methods 179 Genetic approaches for deriving gene function 184 Conditional knockdown of protein function 187 Protein reporters 190 Conclusions 192 Bibliography 192 8 Transcriptomics and proteomics 197 Archana P. Gupta, Zbynek Bozdech, and Peter R. Preiser Transcriptional profiling throughout the parasite life cycle 198 Transcriptional regulation 201 Transcriptional variation 205 Biological insights 208 Proteomics 208 Translational regulation 209 Conclusion 212 Bibliography 212 9 The biochemistry of Plasmodium falciparum: An updated overview 219 Hagai Ginsburg MPMP 219 Carbohydrates 219 Lipid metabolism 227 Amino acids 240 Nucleotide metabolism 252 Cofactors 256 Redox metabolism 265 Mitochondrial functions 268 Hemoglobin digestion and hemozoin production 273 Some reflections for the future 276 Bibliography 277 10 Signaling in malaria parasites 291 Pushkar Sharma and Sudhir Kumar Protein phosphorylation in Plasmodium 291 Calcium mediated signaling in Plasmodium 292 Phosphoinositide signaling and trafficking in malaria parasites 295 Cyclic nucleotide signaling in the malaria parasite 296 Future challenges 300 Bibliography 300 11 Membrane transport proteins as therapeutic targets in malaria 307 Sanjay A. Desai, Kempaiah Rayavara, Paresh Sharma, Sayeed K. Syed, Wang Nguitragool, and Praveen Balabaskaran Nina Host erythrocyte membrane: A shared ion and nutrient channel 308 Parasitophorous vacuolar membrane: Protein export and solute uptake 311 Parasite plasma membrane: Similar to other eukaryotic cells, but different 314 Digestive vacuole: A specialized lysosome equivalent in the parasite 316 Mitochondrial inner membrane: An unusual ATP synthase with uncertain function 318 Conclusions 319 Acknowledgments 319 Bibliography 319 12 The proteolytic repertoire of malaria parasites 325 Puran Singh Sijwali and Philip J. Rosenthal Aspartic proteases 325 Cysteine proteases 330 Metalloproteases 333 Serine proteases 335 Threonine proteases 338 Roles of proteases in parasite development 340 Summary and conclusions 343 Acknowledgments 343 Bibliography 343 13 Development of medicines for the control and elimination of malaria 353 Jeremy N. Burrows and Timothy N. C. Wells Targets for the development of future medicines for malaria 356 The process of drug development 359 Advances in drug development made in the 21st century 365 The global pipeline of new medicines for treating malaria 368 Medicines in the broader context of malaria eradication 370 Conclusion 377 Acknowledgments 377 Bibliography 377 14 Antimalarial drug resistance 383 Naman K. Shah and Neena Valecha Background 383 Causes of drug resistance 386 Detection of drug resistance 390 Managing drug resistance 397 Conclusion 401 Disclosures 401 Bibliography 401 Further reading 407 15 Epidemiology of Plasmodium falciparum malaria 409 Alberto L. Garcia Basteiro, Quique Bassat, and Pedro L. Alonso Burden of disease 409 Geographical distribution of the disease 411 Chain of transmission and infection cycle 413 Malaria endemicity and malaria transmission 415 Malaria elimination and eradication 423 Bibliography 424 16 Malaria pathogenesis 427 Bronner P. Goncalves, Michal Fried, and Patrick E. Duffy Malaria illness 427 Host susceptibility 439 Parasite virulence 444 Conclusions 450 Bibliography 451 17 Host genetics 465 Thomas N. Williams What evidence is there that the risk of malaria is genetically determined? 465 Identifying the genes involved 466 Why is genetic resistance important? 467 Genetic polymorphisms of the red blood cell 468 Hemoglobinopathies 474 G6PD deficiency 478 Non red blood cell polymorphisms 479 Concluding remarks 481 Bibliography 481 18 The immune response in mild and severe malaria: Two sides of the same coin 495 Michael Waisberg, Peter D. Crompton, Louis H. Miller, and Susan K. Pierce The picture of the acquisition of resistance to uncomplicated and severe malaria: Framing the questions 495 Searching for host genes that confer immune resistance to severe malaria 506 SLE susceptibility and resistance to severe malaria 507 The relationship between the pathogen environment and susceptibility to severe malaria 510 Summary 511 Acknowledgments 511 Bibliography 512 19 Progress in development of malaria vaccines 521 Chetan E. Chitnis, Deepak Gaur, and Virander S. Chauhan Immunity to malaria 521 Life cycle of malaria parasites and points of intervention with vaccines 522 Pre erythrocytic stage vaccines 524 Blood stage vaccines 526 Transmission blocking vaccines 533 Live attenuated vaccines for malaria 534 Conclusion 535 Bibliography 535 20 Plasmodium vivax: Insights on burden and pathobiology 547 Ivo Mueller, Quique Bassat, Marcus V. G. Lacerda, and Hernando A. del Portillo Burden of Plasmodium vivax infection and disease 547 Severe Plasmodium vivax malaria 550 Molecular basis of severe disease 552 Concluding remarks and outstanding research questions 558 Bibliography 558 Index 565.
  • (source: Nielsen Book Data)9781118493793 20170313
This title explores malarial biology with insights from post-genomic technologies. The book looks broadly at the disease, vectors of infection, and treatment and prevention strategies.
(source: Nielsen Book Data)9781118493793 20170313
1 online resource (xii, 404 pages.) :.
The book presents recent developments and application of fluorescent protein-labelling techniques and two-photon molecular probes. It introduces research of super-resolution localization microscopy, photoacoustic molecular (functional) imaging, and optical molecular tomography for small animal in vivo. The book illustrates optical labeling techniques and imaging instruments and their application in biological studies.
(source: Nielsen Book Data)9783110304381 20170814