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xiii, 153 pages : illustrations ; 23 cm
Medical Library (Lane)
xiii, 318 p.
  • Contents: Foreword, Arthur L. Caplan-- Introduction-- Selected existing genetic databases: distinctive features, ethical problems and the public debate-- The ethical debate: principles, values and interests - the ethical foundations of guidelines-- Selected issues of consensus and of controversy-- Ethical issues human genetic databases and the future-- References-- Index.
  • (source: Nielsen Book Data)9781409404996 20160612
Following the boom in population databases in recent years there has been sustained and intense international debate about political processes and legal and ethical issues surrounding the protection and use of genetic data. As a result, several national and international organizations and committees have published widely differing guidelines and statements concerning genetic databases and biobanks.
(source: Nielsen Book Data)9781409404996 20160612
iii, 195 p. : ill. ; 26 cm.
Use of the term "multiple chemical sensitivity" (MCS) as a diagnostic label has generated increasing controversy during the past few decades as a phenomenon related to exposure to chemical agents sustained both in indoor and outdoor environments. This volume, prepared in conjunction with "Biologic Markers in Immunotoxicology", contains the authored papers of a workshop held to develop an agenda to study the phenomenon of multiple chemical sensitivity. Authored by clinicians, immunologists, toxicologists, epidemiologists, psychiatrists, psychologists, and others involved in research or clinical activities relevant to the problem, the papers contain case evaluations and criteria for diagnosis, mechanisms potentially underlying MCS, and epidemiologic approaches to investigation.
(source: Nielsen Book Data)9780309047364 20160605
ix, 424 p. : ill.
  • Introduction to gene therapy and guidelines to pharmaceutical development, Sean M. Sullivan-- sustaining transgene expression in vivo, Nelson S. Yew and Seng H. Cheng-- expression systems - regulated gene expression, Jeffrey L. Nordstrom-- mechanismsfor cationic lipids in gene transfer, Lisa S. Uyechi-O'Brien and Francis C. Szoka, Jr-- polymer-based gene delivery systems, Lionel Wightman, Ralf Kircheis, and Ernst Wagner-- chimeric gene delivery systems, Yasufumi Kaneda-- adenoviral vectors for genedelivery, Jonathan L. Bramson and Robin J. Parks-- gene delivery technology - adeno-associated virus, Barrie J. Carter retrovectors go forward, Jean-Christophe Pages and Olivier Danos-- device-mediated gene delivery - a review, Fiona McLaughlin and Alain--Rolland nonviral approaches for cancer gene delivery, Vivian Wai-Yan Lui and Leaf Huang-- replicating adenoviral vectors for cancer therapy, Murali Ramachandra, John A. Howe, and G. William Demers-- cardiovascular gene therapy, Mikko P. Turunen, Mikko O.Hiltunen, Seppo Yla-Herttuala-- pulmonary gene therapy, Jane C. Davies, Duncan M. Geddes, and Eric W.F.W. Alton-- artificial chromosomes, Jonathan Black and Jean-Michel Vos.
  • (source: Nielsen Book Data)9780824742355 20160604
This volume examines the advantages and limitations of the major gene delivery systems and offers guidelines to select the most appropriate viral or synthetic delivery system for specific therapeutic applications. It discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancerous, cardiovascular, pulmonary, genetic, and infectious diseases.
(source: Nielsen Book Data)9780203912331 20160604
xxxvii, 573 pages : illustrations ; 24 cm.
  • 1. Metal Ions and Infectious Diseases. An Overview from the Clinic by Peggy L. Carver 2. Sodium and Potassium in Health and Disease by Hana R. Pohl, John Wheeler, and H. Edward Murray 3. Magnesium in Health and Disease by Andrea M. P. Romani 4. Calcium in Health and Disease by Marisa Brini, Denis Ottolini, Tito Cali, and Ernesto Carafoli 5. Vanadium. Its Role for Humans by Dieter Rehder 6. Chromium: Is It Essential, Pharmacologically Relevant or Toxic? by John B. Vincent 7. Manganese in Health and Disease by Daiana Silva Avila, Robson Luiz Puntel, and Michael Aschner 8. Iron: Effect of Deficiency and Overload by Robert C. Hider and Xiaole Kong 9. Cobalt: Its Role in Health and Disease by Kazuhiro Yamada 10. Nickel and Human Health by Barbara Zambelli and Stefano Ciurli 11. Copper: Effects of Deficiency and Overload by Ivo Scheiber, Ralf Dringen, and Julian F. B. Mercer 12. Zinc and Human Disease by Wolfgang Maret 13. Molybdenum in Human Health and Disease by Guenter Schwarz and Abdel A. Belaidi 14. Silicon: The Health Benefits of a Metalloid by Keith R. Martin 15. Arsenic. Can this Toxic Metalloid Sustain Life? by Dean E. Wilcox 16. Selenium. Role of the Essential Metalloid in Health by Suguru Kurokawa and Marla J. Berry.
  • (source: Nielsen Book Data)9789400774995 20160612
MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.
(source: Nielsen Book Data)9789400774995 20160612
Science Library (Li and Ma)
1 online resource (xi, 291 pages) : illustrations (some color)
  • An overview of the Translational Dilemma and the need for Translational Systems Biology of inflammation.- Part I: Complex Systems Methods and Applications.- Translational Equation-based Modeling.- Agent-based Modeling in Translational Systems Biology.- Analysis of Heart Rate Variability.- Analysis of Ventilatory Pattern Variability.- Part II: Translational Modeling of Sepsis and Trauma.- Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective.- Multi-scale equation-based models: Insights for Inflammation and Physiological Variability.- Integrating Data Driven and Mechanistic Models of the Inflammatory Response in Sepsis and Trauma.- In silico Trials and Personalized Therapy for Sepsis and Trauma.- Part III: Translational Modeling of Wound Healing.- Disorder of Localized Inflammation in Wound Healing: A Systems Perspective.- Equation-based Models of Wound Healing and Collective Cell Migration.- Agent-based Models of Wound Healing.- Part IV: Translational Modeling of Host-pathogen Interactions.- Modeling Host-Pathogen Interactions in Necrotizing Enterocolitis.- Modeling Host-Vector-Pathogen Immuno-inflammatory Interactions in Malaria.- Part V: Future Perspectives.- Translation to Implementation.- The Rationale and Implementation of Translational Systems Biology as a new Paradigm for the Study of Inflammation.- Index.
  • (source: Nielsen Book Data)9781461480075 20160612
The difficulty in achieving effective translation of basic mechanistic biomedical knowledge into effective therapeutics, is the greatest challenge in biomedical research. Nowhere is this more apparent than in the reductionist approaches to understanding and manipulating the acute inflammatory response in the settings of sepsis, trauma/hemorrhage, wound healing, and related processes. This book discusses complex systems and computational biology methods and approaches that have advanced sufficiently to allow for knowledge generation, knowledge integration, and clinical translation in the settings of complex diseases related to the inflammatory response. Well-regulated, self-resolving inflammation is necessary for the appropriate communication and resolution of infection and trauma, and for maintenance of proper physiology and homeostasis. In contrast, self-sustaining inflammation drives the pathobiology of the aforementioned diseases. It is now increasingly recognized that controlling and reprogramming inflammation in order to reap the benefits of this evolutionarily-conserved process is preferred to simply abolishing indiscriminately.
(source: Nielsen Book Data)9781461480075 20160612
xiv, 266 p. : ill.
  • Maldynia: The Illness of Chronic Pain, J. Giordano A Short History of Pain and Its Treatment, A. Valadas From Antiquity to the Medieval Age From Renaissance to Enlightenment The Nineteenth Century Pain in the Twentieth Century Pain Does Not Suffer Misprision: The Presence and Absence that is Pain, J.D. Katz The Positive and Negative Attributes of Pain The Phenomenology of Pain A Humanistic Interpretation of Pain Understanding Suffering: The Phenomenology and Neurobiology of the Experience of Illness and of Pain, P. Moskovitz Perceptions, Emotions and the Experience of Suffering Understanding Consciousness Senses of Consciousness (after Edelman (22), Zeman (52) and others) Consciousness as Wakefulness Consciousness as the Experience of Perceptual Contents Consciousness as Reportable Experience Consciousness as Self-awareness A Theory of Consciousness: How Consciousness and Awareness Happen The Multiple Dimensions of Perceptual Contents Modeling Consciousness - Creating a Diagram of the Body-Brain A Linear Versus an Oscillatory Model of Consciousness Loss That Evokes Grief and Threat That Evokes Fear Unrelieved Appetites and Drive States Pain The Threshold of Suffering Suffering: Shock, Stasis, and Dissociation Resilience and Coping Coping Skills: Connectedness Coping Skills: Symbolic Representation Coping Reactions: Disgust, Contempt and Anger Belief Systems and Spirituality The Outcomes and Products of Suffering How (Can) I Feel Your Pain: The Problem of Empathy and Hermeneutics in Pain Care, G. Venuti Care and Relation: Empathy for Another's Pain Empathy, Sympathy, Compassion: All Synonyms? Spirituality, Suffering and the Self, J. Giordano and N.B. Kohls Introduction Pain, the "Self", and Spirituality Support from Our Empirical Research The Nature and Brief Anthropology of Spiritual and Religious Practices Putative Neural Substrates of Spiritual Experience(s) Patients' Spirituality and Its Importance for the Clinical Practice of Medicine Spirituality and Practical Pain Management Conclusion History of the Expression of Pain in Art, S. Karakas Maldynia as Muse: A Recent Experiment in the Visual Arts and Medical Humanities, N. Carlin and T. Cole Perceptions of Pain: The Essays Looking at Pain A Visual Language for Pain Unspeakable Pain Perceptions in Pain: The Art The Process Three Photographs: Interpretations Contextualizing Perceptions of Pain Conclusions and Recommendations Padfield's Call for Psychological Interpretations Maldynia as Muse Maldynic Pain in Image and Experience: Engraving Meaning through Subtraction, R. Covey Musical Representations of Physical Pain, E. Peterson Introduction Pain and Language Pain and Its Object Music and Meaning Music and Timbre Music and Lyrics: Masochism Tango Music as Absolute: Pacific 231 Film Music: Psycho Classical Music: Threnody for the Victims of Hiroshima Popular Music: Back to Back Screaming as Music Conclusion: Pushing Boundaries Beyond Technology: Narrative in Pain Medicine, L. Galvagni Narrative and Communication in the Experience of Pain as Illness Narrative Medical Ethics A Phenomenology of Pain as Illness Embodiment Temporality Subjectivity Metaphors and Images in the Experience of Pain as Illness Psychological Assessment of Maldynic Pain: The Need for a Phenomenological Approach, M. Schatman Introduction The Importance of Phenomenologically Assessing the Chronic Pain Patient The MMPI: A Tarnished "Gold Standard" Unidimensional Assessment Tools Multiscale Multidimensional Assessment Tools The Strength and Meaning of the Clinical Interview A "Patient-Centered" Approach to Assessment of Maldynic Pain Patients Cross-Cultural Sensitivity Conclusion Painism- A New Ethics: Richard Ryder's Moral Theory and Its Limitations, H. Werner-Ingensiep Introduction "Can they suffer?" Ryder's Painism: A Middle Way Between the Scylla of Utilitarianism and the Charybdis of Rights Theory? Is Pain Necessary and/or Sufficient for Moral Status? Painism and Sentientism Hurting and Harming Pain - The Only Evil? Pain in Non-Human Others: Speciesism- Normative and Descriptive Dimensions Species, individuals, and Pain Painism - Some Applications and Questions Painism and Biotechnology Painism and Environmental Ethics Painism and Plants Painism and Euthanasia Brain, Pain, PVS and Extreme Cases Who is the "maximum sufferer"? Concerning the "Vegetative Language" about Human Beings Beyond Sentience and Pain Maldynia: Chronic Pain, Complexity and Complementarity, J. Giordano and M.V. Boswell Introduction: A Complex Problem Chronic Pain - A Spectrum Disorder? A Call for Complementarity in Pain Care Precipitating Change Navigating the Technologic Trend Realizing Complementarity in Practice The Current Condition of Pain Care Proposing a Future An Ethical Stance Conclusion: A Way Forward A Clinical Ethics of Chronic Pain Management: Basis, Reason and Responsibilities, E. Pellegrino On Pain, Briefly The Moral Management of Pain as Illness The Pain Patient Ethical Obligations in Clinical Contexts Children, Pain, and the Creation of Suffering: Toward an Ethic of Lamentation, C. Gomez Finding the Words: A Patient's Story A Framework for Analysis Chronic Pain and Language Goal-Directed Health Care and the Chronic Pain Patient: A New Vision of the Healing Encounter, D. Waters and V. Sierpina Goal-Directed Health Care (G-DHC) G-DHC: A Background Health Goals And Life Goals Changing The Dialogue A New Vision Of The Healing Encounter Case 1 Case 2 The Problem of Pain and the Moral Formation of Physicians, F.D. Davis Introduction Pain, Illness, and the Ends of Medicine The Culture of Medicine and the Moral De-Formation of Physicians Patients, Pain, and Prospects for Change in the Culture of Medicine.
  • (source: Nielsen Book Data)9781439836316 20160605
Whether initiated by injury or disease, induced and sustained by changes in the nervous system, or manifested by society and culture, chronic pain can change one's first-person experience of the body and the world, and ultimately impacts cognitions, emotions, and behavior. Many fine medical books address the causes and management of chronic intractable pain, but rarely do they focus on the ways that such pain creates illness and is experienced and expressed by persons in pain. Maldynia: Multidisciplinary Perspectives on the Illness of Chronic Pain is about chronic pain that has progressed to a multidimensional illness state in and of itself. Although often dismissed as such, this pain is not imaginary, but rather represents an interaction of neurobiological processes, emotional and behavioral responses, and socio-cultural effects and reactions that become enduring elements in the life and world of the pain patient, and often remain enigmatic for those who provide care. Taking a comprehensive approach that covers science, humanities, and culture, this volume emphasizes the need for researchers, clinicians, and caregivers to regard the ways in which chronic intractable pain becomes illness and affects a patient's biological, social, and psychological states, as well as his or her sense of self. Edited by neuroscientist and neuroethicist James Giordano, this book contains 17 insightful chapters representing medicine, neuroscience, psychology, philosophy, ethics, history, art, and the ministry. This exceptional volume also looks at representations of pain in and through the arts, addresses the assignation of values and meaning in pain assessment and treatment, and considers ways to conjoin the sciences and humanities so as to inform the practice of pain medicine and improve the care of those suffering the illness of chronic pain.
(source: Nielsen Book Data)9781439836316 20160605
686 p. : ill.
  • Introduction-- Robert Langer, MIT, Cambridge, MA GENE DELIVERY: CHALLENGES AND OPPORTUNITIES Tissue and Cell Specific Targeting for the Delivery of Genetic Information-- Randall J. Mrsny, University of Wales, UK Biological Barriers to Gene Transfer-- Yasufumi Kaneda, Osaka University, Japan Cellular Uptake and Trafficking-- Sujatha Dokka and Yon Rojanasakul, West Virginia University. Morgantown, WV, USA Pharmacokinetics of Polymer/Plasmid DNA Complex-- Makiya Nishikawa, Yoshinobu Takakura, and Mitsuru Hashida, Kyoto University, Japan CONDENSING POLYMERIC SYSTEMS A. Non-Degradable Polymers Poly(L-Lysine) and Copolymers for Gene Delivery-- Minhyung Lee and Sung Wan Kim, University of Utah, Salt Lake City, USA Gene Delivery Using Polyethyleneimine and Copolymers-- Manfred Ogris, Centre of Drug Research, LMU Munich, Germany Chapter 8. Poly(2-(Dimethylamino)Ethyl Methacrylate)-Based Polymers for the Delivery of Genes In Vitro and In Vivo-- .J. Verbaan, D.J.A. Crommelin, W.E. Hennink, and G. Storm, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands Cationic Dendrimers as Gene Transfection Vectors-- Lori A. Kubasiak and Donald A. Tomalia, Dendritic Nanotechnologies, Inc., Mt. Pleasant, MI Poly(ethylene glycol)-Conjugated Cationic Dendrimers-- Joon Sig Choi, Tae-il Kim, and Jong-Sang Park, Seoul National University, Korea Water Soluble Lipopolymers for Gene Delivery-- Ram I. Mahato, University of Tennessee Health Science Center, Memphis, and Sung Wan Kim, University of Utah, Salt Lake City, USA Cyclodextrin-Containing Polymers for Gene Delivery-- Suzie Hwang Pun, Insert Therapeutics, Pasadena, CA, and Mark E. Davis, California Institute of Technology, Pasadena, CA, USA B. Biodegradable Polymers Gene Delivery Using Polyimidazoles and Related Polymers-- Sharon Wong and David Putnam, Cornell University, Ithaca, NY, USA Poly(?-amino ester)s for Gene Delivery-- David M. Lynn, University of Wisconsin, Madison, WI, and Daniel G. Anderson, Akin Akinc, and Robert Langer, Massachusetts Institute of Technology, Cambridge, MA, USA Cationic Polyesters as Biodegradable Gene Delivery Carriers-- Yong-beom Lim, Yan Lee, and Jong-Sang Park, Seoul National University, Korea Poly(amidoamine)s for Gene Delivery-- Paolo Ferruti and Jacopo Franchini, University of Milan, Italy Chapter 17. Cationic Polysaccharides for Gene Delivery-- Tony Azzam and Abraham J. Domb, The Hebrew University - Hadassah Medical School, Jerusalem, Israel Chitosan Complexes-- Gerrit Borchard and Maytal Bivas-Benita, Leiden University, The Netherlands NON-CONDENSING POLYMERIC SYSTEMS Pluronic(R) Block Copolymers for Non-Viral Gene Delivery-- Alexander V. Kabanov and Srikanth Sriadibhatla, University of Nebraska Medical Center, Omaha, NE, and Valery Yu. Alakhov, Supratek Pharma, Inc., Dorval, Quebec, Canada Use of Poly(N-vinyl pyrrolidone) with Noncondensed Plasmid DNA Formulations for Gene Therapy and Vaccines-- Michael Nicolaou and Mark Newman, Epimmune, Inc., San Diego, CA, Polly Chang, SRI International, Menlo Park, CA, USA Use of HPMA Copolymers for Gene Delivery-- David Oupicky, Wayne State University, Detroit, MI, USA POLYMERIC NANOSPHERES AND MICROSPHERES A. Polymeric Nanospheres Biodegradable Nanoparticles as Gene Expression Vector-- Swayam Prabha, Wenxue Ma, and Vinod Labhasetwar, University of Nebraska Medical Center, Omaha, USA Nanoparticles Made of Poly(lactic acid) and Poly(ethylene oxide) as Carriers of Plasmid DNA-- Noemi Csaba, Celso Perez, Alejandro Sanchez, and Maria Jose Alonso, University of Santiago de Compostela, Spain Poly(alkylcyanoacrylate) Nanoparticles for Nucleic Acid Delivery-- Elias Fattal and Patrick Couvreur, University of Paris-Sud, France Layer-by-Layer Nanoengineering with Polyelectrolytes for Bioactive Compound Delivery Applications-- Dinesh B. Shenoy, Alexei A. Antipov, and Gleb B. Sukhorukov, Max-Planck Institute of Colloids and Interfaces, Potsdam/Golm, Germany Ex Vivo and In Vivo Adenovirus-Mediated Gene Delivery intro Refractory Cells via Nanoparticle Hydrogel Formulation-- Ales Prokop and Gianluca Carlesso, Vanderbilt University, Nashville, TN, and Jeffrey M. Davidson, Department of Veteran Affairs Medical Center, Nashville, TN, USA Protein Nanoparticles for Gene Delivery-- Goldie Kaul and Mansoor Amiji, Northeastern University, Boston, MA, USA B. Polymeric Microspheres Gene Delivery Using Poly(lactide-co-glycolide) Microspheres-- Mary Lynne Hedley-- Zycos, Inc.-- Lexington, MA, USA Polyanhydride Microspheres for Gene Delivery-- Yong S Jong and Camilla A Santos, Spherics Inc., Lincoln, RI, and Edith Mathiowitz, Brown University, Providence, RI, USA Microspheres Formulated with Native Hyaluronan for Applications in Gene Therapy-- Yang H. Yun and Weiliam Chen, State University of New York at Stony Brook, Stony Brook, NY, USA SPECIALIZED DELIVERY SYSTEMS Genetically Engineered Protein-Based Polymers: Potential in Gene Delivery-- Zaki Mageed and Hamid Ghandehari, University of Maryland, Baltimore, MD, USA Glycopolymer Tools for Studying Targeted Non-Viral Gene Delivery-- Kevin G. Rice, Je-Seon Kim, and Dijie Liu, University of Iowa, Iowa City, USA Targeted Gene Delivery via the Folate Receptor-- Shih-Jiuan Chiu and Robert J. Lee, Ohio State University, Columbus, USA Transferrin Receptor-Targeted Gene Delivery Systems-- Ralf Kircheis, Igeneon Immunotherapy of Cancer, Vienna, Austria, and Ernst Wagner, Pharmaceutical Biology/Biotechnology, Ludwig-Maximilians University, Munich, Germany Gene Delivery to the Lungs-- Berma M. Kinsey, Charles L. Densmore, and Frank M. Orson, Baylor College of Medicine, Houston, TX, USA Cutaneous Gene Delivery-- James C. Birchall, Cardiff University, Wales, UK Enhancement of Wound Repair by Sustained Gene Transfer via Hyaluronan Matrices-- Angela Kim, Daniel M. Checkla, Don Wen, Philip Dehazya, and Weiliam Chen1, Clear Solutions Biotech, Inc., Stony Brook, NY, and 1State University of New York at Stony Brook, NY, USA Gene Delivery from Tissue Engineering Matrices-- Zain Bengali, Christopher B. Rives, and Lonnie D. Shea, Northwestern University, Evanston, IL, USA Gene Therapy Stents for Instent Restenosis-- Ilia Fishbein, Itay Perlstein, and Robert Levy, University of Pennsylvania Medical Center and Children's Hospital of Philadelphia, PA USA Gene Delivery Using BioMEMS-- Krishnendu Roy, University of Texas, Austin, USA.
  • (source: Nielsen Book Data)9780849319341 20160604
To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry, and limited scale of industrial production. Polymeric Gene Delivery: Principles and Applications is the first comprehensive book to specifically address polymeric gene delivery systems. Uniting the expertise of international academic and industrial scientists who are working in the area of polymeric vectors for gene delivery, it is written by prominent researchers directly involved in this field. The book is divided into five sections that deal with challenges and opportunities in gene delivery and the efficient delivery of genes into somatic cells using polymeric vectors. The authors discuss using biodegradable polymers, condensing and non-condensing polymeric systems, microspheres and nanospheres, and designing specialized delivery systems based on targeting strategies. Polymeric Gene Delivery: Principles and Applications accentuates the versatility of polymeric delivery systems, including the potential for biocompatibility, the ability to design their formulation and geometry for a specific purpose, and the ease of modification to the surface of polymeric carriers. This book is an up-to-date guide for researchers in the field and those interested in entering this dynamic field.
(source: Nielsen Book Data)9780849319341 20160604


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