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volumes ; 30 cm
SAL3 (off-campus storage)
1 online resource.
  • Foreword Preface Section 1 1.1 Definition, prevalence and historical perspectives of obesity in adults 1.2 Definition, prevalence and historical perspectives of obesity in children 1.3 Development of overweight and obesity across the life course 1.4 Diagnostic Criteria and Assessment of Obesity in Adults 1.5 Diagnostic criteria and assessment of obesity in children Section 2 2.1 Obesity in the development of type 2 diabetes 2.2 Obesity in the development of cardiovascular disease 2.3 Obesity as a risk factor in the development of cancer 2.4 Obesity as a risk factor in osteoarthritis and pulmonary disease 2.5 Psychology and mental health disorders in obesity 2.6 Binge eating and obesity Section 3 3.1 Genetics and epigenetics in the aetiology of obesity 3.2 Food intake and appetite in the aetiology of obesity 3.3 Physiological control of appetite and food intake 3.4 Obesogenic medication in the aetiology of obesity 3.5 GUT MICROBIOME IN OBESITY 3.6 Physical activity and physical inactivity in the aetiology of obesity 3.7 Obesogenic environment and obesogenic behaviours Section 4 4.1 Macronutrient composition for weight loss in obesity 4.2 Meal replacements for weight loss in obesity 4.3 formula diets for weight loss in obesity 4.4 Group-based interventions for weight loss in obesity 4.5 Commercial weight management organisations for weight loss in obesity 4.6 Fad diets and fasting for weight loss in obesity 4.7 Pharmacological management of weight loss in obesity 4.8 Diet to support pharmacological management of weight loss 4.9 Surgical management of weight loss in obesity 4.10 Diet to support surgical management of weight loss 4.11 PHYSICAL ACTIVITY FOR WEIGHT LOSS IN OBESITY 4.12 Psychological interventions for weight loss in obesity 4.13 Weight loss interventions in specific groups: overweight and obese men 4.14 Weight loss interventions in specific groups: intellectual disabilities 4.15 Weight Maintenance following weight loss in obesity 4.16 Economic cost of obesity and the cost effectiveness of weight management Section 5 5.1 Genetics, epigenetics and obesity: focus on studies in children 5.2 Food intake, eating behaviour and obesity in children 5.3 Physical activity and inactivity in the aetiology of obesity in children Section 6 6.1 Diet in the management of weight loss in childhood obesity 6.2 Physical Activity in the management of weight loss in childhood obesity 6.3- Psychological and behavioural interventions in childhood obesity 6.4 Residential programmes and weight loss camps in childhood obesity 6.5 Pharmacological management of weight loss in childhood obesity 6.6 Surgical management of weight loss in childhood obesity Section 7 7.1 National campaigns to modify eating behaviour in the prevention of obesity 7.2 Increasing physical activity to prevent childhood obesity 7.3 Designing public health initiatives for the prevention of obesity Index.
  • (source: Nielsen Book Data)9780470670767 20171211
This addition to the British Dietetic Association Advanced Nutrition and Dietetics book series is written for clinicians and researchers who work with any aspect of obesity and its comorbid conditions. Featuring contributions from leading researchers and practitioners from around the globe Advanced Nutrition and Dietetics in Obesity offers a uniquely international perspective on what has become a worldwide public health crisis. Chapters cover a full range of new ideas and research on the underlying drivers of obesity in populations including discussions on the genetic and clinical aspects of obesity, along with expert recommendations on how to effectively manage and prevent this chronic and persistent disease. Providing a comprehensive overview of the key literature in this field, Advanced Nutrition and Dietetics in Obesity is an invaluable resource for all those whose work should or does embrace any aspect of obesity.
(source: Nielsen Book Data)9780470670767 20171211
xi, 217 pages ; 22 cm
  • Introduction.- Chapter 1: AIDS in the Islamic Republic.- Chapter 2: The HIV prevention market.- Chapter 3: Enterprising bureaucrats.- Chapter 4: Surviving hard times.- Chapter 5: Participating in the Global Fund.- Chapter 6: Responsibility for care and support.- Chapter 7: AIDS activism.- Conclusion.
  • (source: Nielsen Book Data)9789811062193 20171218
This book is the first full-length study of HIV/AIDS work in relation to government and NGOs. In the early 2000s, Pakistan's response to HIV/AIDS was scaled-up and declared an area of urgent intervention. This response was funded by international donors requiring prevention, care and support services to be contracted out to NGOs - a global policy considered particularly important in Pakistan where the high risk populations are criminalized by the state. Based on unparalleled ethnographic access to government bureaucracies and their dealings with NGOs, Qureshi examines how global policies were translated by local actors and how they responded to the evolving HIV/AIDS crisis. The book encourages readers to reconsider the orthodoxy of policies regarding public-private partnership by critiquing the resulting changes in the bureaucracy, civil society and public goods. It is a must-read for students, scholars and practitioners concerned with neoliberal agendas in global health and development.
(source: Nielsen Book Data)9789811062193 20171218
SAL3 (off-campus storage)
x, 194 pages : illustrations ; 25 cm.
  • The gay science : intimate experiments with the problem of HIV
  • Queer chemistry : gay partying and collective innovations in care
  • Click here for HIV status : sorting for sexual partners
  • Making up barebackers
  • Reluctant objects : pre-exposure prophylaxis and negative sex
  • Framing responsibility : accounting for objects, networks and events
  • Chemsex : a case for gay analysis
  • Speculative intimacies : some less acknowledged possibilities of smart phone use
  • Conclusion : the queer chemistry of counterpublic health in digital times.
Green Library
volumes : illustrations ; 28 cm
Business Library
volumes : illustrations ; 28 cm
Medical Library (Lane)
1 online resource (514 p.) : ill. (some col.)
"Healthcare Policies and Systems in Europe and China, a product of an interdisciplinary European Union-funded project, comprehensively investigates opportunities for mutual integration in the healthcare sector of the two regions and analyses policies at both national and local levels, the legal environment, medical practices, as well as the state of respective healthcare industries and related businesses. The book sheds light on both the potential benefits and obstacles to the integration of Chinese and Western medicine, as well as practices and industries in Europe and China. An interdisciplinary approach is adopted throughout using tools and technical knowledge derived from the economics, social sciences, legal and medical fields. This edited volume seeks to provide guidelines and policy proposals for policy-makers both in Europe and China, as well as offer operational suggestions for companies working in or with China, to enhance bilateral trade and investment flows. It also presents medical evidence and economic/legal analysis that will help boost the integration of traditional Chinese medicine with Western medicine through research studies. This is a recommended read for graduates, researchers and policy-makers seeking for a holistic understanding of healthcare policies and systems, both in theory and in practice."-- Provided by publisher.
1 online resource (xix, 330 pages ): illustrations.
  • 1. Mutagenesis and health problems2. Molecular mechanisms of mutagenesis3. Bacterial mutation assays4. Gene mutation assays in cultured mammalian cells5. Chromosomal aberration test6. In vivo cytogenetic assay7. Mutagenicity testing in environmental pollution control8. Mutagens in food and water9. Emerging methods for the identification of mutagens10. Guidelines and registration of the new compounds or drug like molecules11. Mutagenicity testing, regulatory guidelines and current needs.
  • (source: Nielsen Book Data)9780128092521 20171211
Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation.
(source: Nielsen Book Data)9780128092521 20171211
1 online resource.
  • 1. Mutagenesis and health problems2. Molecular mechanisms of mutagenesis3. Bacterial mutation assays4. Gene mutation assays in cultured mammalian cells5. Chromosomal aberration test6. In vivo cytogenetic assay7. Mutagenicity testing in environmental pollution control8. Mutagens in food and water9. Emerging methods for the identification of mutagens10. Guidelines and registration of the new compounds or drug like molecules11. Mutagenicity testing, regulatory guidelines and current needs.
  • (source: Nielsen Book Data)9780128092521 20171204
Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation.
(source: Nielsen Book Data)9780128092521 20171204
1 online resource.
  • Front Cover; Neuroepidemiology in Tropical Health; Copyright Page; Contents; List of Contributors; Foreword; References; Is Tropical Neurology Specific?; Cultural Issues; The Role of Sunshine; The Role of Genetic Factors; References; I. Fundamental Concepts; 1 Methodological Challenges of Neuroepidemiological Studies in Low- and Middle-Income Countries; 1.1 Introduction; 1.2 Study design and Feasibility in the Field; 1.3 General Context; 1.3.1 Geographical Difficulties; 1.3.2 How to Move Forward?; 1.3.3 Systematic Review and Meta-Analysis; 1.3.4 Socioeconomic and Sociocultural Factors
  • 1.4 Difficulties in the Availability and Mobilization of Data1.4.1 Medical Data; 1.4.2 General Population Census; 1.4.3 Cartography and Geographical Information Systems; 1.5 Study Design; 1.5.1 Geographical and Logistical Challenges; 1.5.2 Demographic and Follow-Up Issues; 1.6 Clinical and Regulatory Issues; 1.6.1 International Ethic Rules; 1.6.2 Suspected Cases Ascertainment; 1.6.3 Diagnostic and Treatment; 1.7 Design-Specific Issues; 1.7.1 Cases Census and Sample Studies; 1.7.2 Involvement of Institutions and Key Stakeholders
  • 1.7.3 Medical Examinations, Biological Specimens and Laboratory Tests1.7.4 Monitoring and New Technologies; 1.8 Valorization: Scientific and Public Health Issues; 1.8.1 International Acknowledgments of the Works Conducted in Tropical Areas; 1.8.2 Advocacy-Policy and International Cooperation; 1.9 Conclusion; References; II. Tropical Neuroepidemiology: Between Environment and Genetics; 2 Sociocultural Factors; 2.1 Introduction; 2.2 Tropical Neuroepidemiology and Health Anthropology: For Effective Collaboration; 2.2.1 The Expected and Assumed Collaborative Epidemiology/Anthropology
  • 2.2.2 A Concept: Almost Exclusive Use of the Sociocultural Representation Theory2.2.3 Health-Related Stigma; 2.3 Mental Disorders and Traditional Beliefs in SSA; 2.3.1 Explanatory Models of Mental Illness in SSA; What are the Theories of Mankind in SSA?; Causality of Mental Illness in SSA; Psychosis and Neurosis; Stigma and Mental Illness; Managing Mental Illness: Traditional or Modern Medicine?; 2.4 Sociocultural Representations and Stigma in Epilepsy; 2.4.1 Explanatory Models of Epilepsy; 2.4.2 Symptomatic Denominations
  • 2.4.3 Etiological Denominations2.4.4 Beliefs About Epilepsy in SSA; Magical Causes (Evil-Spirit, Possession, and Witchcraft); Contagion; "Biomedical Model": Foreign Body Migration, Body Fluids-Bound, and Heredity; Epilepsy and Stigma; 2.5 Sociocultural Representations and Stigma in Dementia; 2.5.1 Models of Understanding of Dementia; 2.5.2 Social Tolerance of People With Dementia: Representations and Stigma; 2.6 Conclusion; References; Further Reading; 3 Climatic Factors Under the Tropics; 3.1 Introduction
"Neuroepidemiology in Tropical Health covers major neurological diseases of relevance in tropical settings and examines the specificities of epidemiology of neurological diseases in the context of tropical countries that face many challenges when compared to the developed world. Part One focuses on methods and their eventual specificities, and how such methods, like sampling, can be adapted for specific scenarios. Parts Two and Three discuss environmental factors and their consequences for neurology in the tropical world, as well as large geographical areas and their specificities. Finally, Part Four presents relevant neurological diseases in in-depth chapters. This invaluable information will help readers recognize the various neurological conditions presented, with the inclusion of their aetiologies and treatment in tropical areas. The book therefore fills a gap in the neuroepidemiology literature, with chapters written by an international collection of experienced authors in the field. Highlights differences and similarities between neuroepidemiology in tropical areas and temperate zones with a focus on methods and underlying factorsCovers environmental factors in the tropical world and their consequences for neurologyChapters include references (key articles, books, protocols) for additional detailed studyIncludes wide topics of neurological disease in the tropics, not only infectious diseases, but also nutrition and public health"-- Provided by publisher.
199 p. : illustrations ; 22 cm.
SAL3 (off-campus storage)
xiv, 155 pages : illustrations ; 22 cm.
  • Chapter 1. Introduction-- Btihaj Ajana.- Chapter 2. Engagement and the Quantified Self: Uneventful relationships with ghostly companions-- Paolo Ruffino.- Chapter 3. Apps as companions: How Quantified Self apps become our audience and our companions-- Jill Walker Rettberg.- Chapter 4. Human/technology associations in self-tracking practices-- Dorthe Brogard Kristensen and Carolin Prigge.- Chapter 5. Social media and self-tracking: Representing the `health self'-- Rachael Kent.- Chapter 6. Self-tracking as the mobilisation of the social for capital accumulation-- Chris Till.- Chapter 7. The quantified workplace: A study in self-tracking, agility and change management-- Phoebe Moore, Lukasz Piwek, and Ian Roper.- Chapter 8. Data privacy: Users' thoughts on Quantified Self personal data-- Keith Spiller, Kirstie Ball, Arosha Bandara, Maureen Meadows, Ciaran McCormick, Bashar Nuseibeh and Blaine A. Price.- Chapter 9. Communal self-tracking: Data philanthropy, solidarity and privacy-- Bithaj Ajana.
  • (source: Nielsen Book Data)9783319653785 20171204
This book provides an empirical and philosophical investigation of self-tracking practices. In recent years, there has been an explosion of apps and devices that enable the data capturing and monitoring of everyday activities, behaviours and habits. Encouraged by movements such as the Quantified Self, a growing number of people are embracing this culture of quantification and tracking in the spirit of improving their health and wellbeing. The aim of this book is to enhance understanding of this fast-growing trend, bringing together scholars who are working at the forefront of the critical study of self-tracking practices. Each chapter provides a different conceptual lens through which one can examine these practices, while grounding the discussion in relevant empirical examples. From phenomenology to discourse analysis, from questions of identity, privacy and agency to issues of surveillance and tracking at the workplace, this edited collection takes on a wide, and yet focused, approach to the timely topic of self-tracking. It constitutes a useful companion for scholars, students and everyday users interested in the Quantified Self phenomenon.
(source: Nielsen Book Data)9783319653785 20171204
Green Library
1 streaming video file (55 min.) : digital, sound, color
How the failure of key individuals, prominent NGO's, and governments to act allowed a catastrophe to fester - a catastrophe that undoubtedly could have been avoided. Since it appeared 20 years ago, AIDS has left behind it a trail of destruction. This film answers the question 'why did the world wait so long to react', and dissects the key moments in the global response to the epidemic. By examining this human catastrophe, the film reveals a global rift that helped the disease to spread.
pages ; cm.
  • Introduction. Definitions and Basic Concepts for Survival Data in a Cohort without Covariates. Developing Absolute Risk Models from Cohort Data with Covariates. Estimating Absolute Risk from Case-Cohort and Nested Case-Control Data. Estimating Absolute Risk from Population-Based Case-Control and Registry Data. Evaluation of Adequacy of Model. Comparing Two Models. Special Topic: Disease Prognosis. Special Topic: Family-Based Designs.
  • (source: Nielsen Book Data)9781466561656 20171218
Absolute Risk: Methods and Applications in Clinical Management and Public Health provides theory and examples to demonstrate the importance of absolute risk in counseling patients, devising public health strategies, and clinical management. The book provides sufficient technical detail to allow statisticians, epidemiologists, and clinicians to build, test, and apply models of absolute risk. Features: * Provides theoretical basis for modeling absolute risk, including competing risks and cause-specific and cumulative incidence regression * Discusses various sampling designs for estimating absolute risk and criteria to evaluate models * Provides details on statistical inference for the various sampling designs * Discusses criteria for evaluating risk models and comparing risk models, including both general criteria and problem-specific expected losses in well-defined clinical and public health applications * Describes many applications encompassing both disease prevention and prognosis, and ranging from counseling individual patients, to clinical decision making, to assessing the impact of risk-based public health strategies * Discusses model updating, family-based designs, dynamic projections, and other topics Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis. Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association. Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.
(source: Nielsen Book Data)9781466561656 20171218
1 streaming video file (25 min.) : digital, sound, color.
Lillian Cingo has one great luxury in her life -- a mini whirlpool to soak her sore feet. It's a small self-indulgence for a woman who spends all day on her feet, from dawn to dusk. Lillian's job is, literally, to keep her hospital on track. She's the manager of the Phelophepa health train that spends nine months each year touring the poorest, most remote areas of South Africa. This Life program catches up with the train in the province of KwaZulu Natal, where there's just one doctor for every 4,000 people. With a full contingent of volunteer doctors, dentists, optometrists and health educators on board, the 'Good Clean Health Train' delivers quality health care to deprived rural communities.
vii, 128 pages : illustrations, map ; [ca. 23-29] cm
  • Iron overload intolerance in Balb/c mice N. Anggraeni, M.R.A.A. Syamsunarno, R.D. Triatin, D.A. Setiawati, A.B. Rakhimullah, C.C. Dian Irianti, S. Robianto, F.A. Damara, D. Dhianawaty & R. Panigoro Mapping of health care facilities in the universal coverage era at Bandung District, Indonesia N. Arisanti, E.P. Setiawati, I.F.D. Arya & R. Panigoro Influence of phosphatidylcholine on the activity of SHMT in hypercholesterolemic rats A. Dahlan, H. Heryaman, J.B. Dewanto, F.A. Damara, F. Harianja & N. Sutadipura Molecular detection of DHA-1 AmpC beta-lactamase gene in Enterobacteriaceae clinical isolates in Indonesia B. Diela, S. Sudigdoadi, A.I. Cahyadi, B.A.P. Wilopo, I.M.W. Dewi & C.B. Kartasasmita Correlation between natrium iodide symporter and c-fos expressions in breast cancer cell lines A. Elliyanti, N. Noormartany, J.S. Masjhur, Y. Sribudiani, A.M. Maskoen & T.H. Achmad Fat mass profile in early adolescence: Influence of nutritional parameters and rs9939609 FTO polymorphism S.N. Fatimah, A. Purba, K. Roesmil, G.I. Nugraha & A.M. Maskoen A study of the palatal rugae pattern as a bioindicator for forensic identification among Sundanese and Malaysian Tamils R. Khaerunnisa, M. Darjan & I.S. Hardjadinata Effect of acrylamide in steeping robusta coffee (Coffea canephora var. robusta) on memory function and histopathological changes of brain cells in male rats (Rattus norvegicus) D.Y. Lestari, M. Bahrudin, Rahayu, Fadhil & A.W. A'ini Effects of aerobic exercise and a high-carbohydrate diet on RBP4 expression in rat skeletal muscle N. Najmi, Y. Sribudiani, B.S. Hernowo, H. Goenawan, Setiawan, V.M. Tarawan & R. Lesmana Correlation of physical activity and energy balance with physical fitness among the professors of the University of Padjadjaran J. Ninda, L. Lubis, A. Purba, I.B. Akbar, W. Karhiwikarta, Setiawan, V.M. Tarawan, R. Farenia, G.I. Nugraha, M. Rizky Akbar, D.K. Sunjaya, S. Rachmayati, I. Ruslina, Hanna, T. Hidayat, P. Tessa, N. Sylviana, Ronny, T. Nurhayati, Y.S. Pratiwi, N.V. Utami, Juliati, S.N. Fatimah, Y. Indah & F. Huda Molecular biology of irreversible pulpitis: A case report D. Prisinda & A. Muryani Effect of different doses of X-ray irradiation on survival of human esophageal cells I.M. Puspitasari, R. Abdulah, M.R.A.A. Syamsunarno & H. Koyama The effect of mesenchymal stem cells on the endothelial cells of diabetic mice A. Putra, A. Rahmalita, Y. Tarra, D.H. Prihananti, S.H. Hutama & N.A.C. Sa'diyah Effects of selenium on SePP and Apo B-100 Gene expressions in human primary hepatocytes M. Putri, N. Sutadipura, S. Achmad, C. Yamazaki, S. Kameo, H. Koyama, M.R.A.A. Syamsunarno, T. Iso & M. Kurabayashi Inhibition of cAMP synthesis abolishes the impact of curcumin administration in the skeletal muscle of rodents H.R.D. Ray & K. Masuda Effect of Monosodium Glutamate (MSG) on spatial memory in rats (Rattus norvegicus) R. Razali, S. Redjeki & A.A. Jusuf Mycobacterium tuberculosis load and rifampicin concentration as risk factors of sputum conversion failure E. Rohmawaty, H.S. Sastramihardja, R. Ruslami & M.N. Shahib Interleukin-22 serum in comedonal acne vulgaris: Proof of inflammation K. Ruchiatan, R. Hindritiani, E. Sutedja & S. Maulinda Pharmacokinetic optimization of the treatment of TB meningitis with TB drugs R. Ruslami Iron-chelating effect of Caesalpinia sappan extract under conditions of iron overload R. Safitri, D. Malini, A.M. Maskoen, L. Reniarti, M.R.A.A. Syamsunarno & R. Panigoro The role of S.aureus and L.plantarum as an immunomodulator of IFNα macrophages and fibronectin dermal fibroblast secretion R.S.P. Saktiadi, S. Sudigdoadi, T.H. Madjid, E. Sutedja, R.D. Juansah, T.P. Wikayani, N. Qomarilla & T.Y. Siswanti Exon globin mutation of ss-thalassemia in Indonesian ethnic groups: A bioinformatics approach N.I. Sumantri, D. Setiawan & A. Sazali Serum immunoglobulin-E level correlates with the severity of atopic dermatitis O. Suwarsa, E. Avriyanti & H. Gunawan Fatty liver in fasted FABP4/5 null mice is not followed by liver function deterioration M.R.A.A. Syamsunarno, M. Ghozali, G.I. Nugraha, R. Panigoro, T. Iso, M. Putri & M. Kurabayashi The potential of seluang fish (Rasbora spp.) to prevent stunting: The effect on the bone growth of Rattus norvegicus Triawanti, A. Yunanto & D.D. Sanyoto Effect of cryoprotectants on sperm vitrification R. Widyastuti, R. Lesmana, A. Boediono & S.H. Sumarsono Mucoprotective effect of Trigona propolis against hemorrhagic lesions induced by ethanol 99.5% in the rat's stomach V. Yunivita & C.D. Nagarajan.
  • (source: Nielsen Book Data)9781351804189 20171218
Advances in Biomolecular Medicine contains the selected papers presented at the 4th BIBMC (Bandung International Biomolecular Medicine Conference) and the 2nd ACMM (ASEAN Congress on Medical Biotechnology and Molecular Biosciences), hosted by the Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia, 4-6 October 2016. In line with the United Nations Sustainable Development Goals, the theme of the joint scientific meeting is `Medical innovation & translational research to ensure healthy lives & promote well-being for all at all ages'. Authors include scientists, academics, practitioners, regulators and other key individuals with expertise and experience relevant to biomolecular medicine, medical biotechnology and molecular biosciences. Topics of the papers cover various aspects of infection, oncology, tuberculosis, genetics, thalassemia, nutrition, cardiovascular, wound healing and endocrinology. This book is essential reading for academics, scientist, practitioners and regulators involved in the area of biomolecular medicine, medical biotechnology and molecular biosciences.
(source: Nielsen Book Data)9781351804189 20171218
1 online resource.
  • List of contributors xiii Foreword xvii Preface xix 1 Introduction: An overview of malaria and Plasmodium 1 Virander S. Chauhan, Chetan E. Chitnis, and Deepak Gaur History 1 The life cycle of Plasmodium 3 A significant milestone in malaria research: Adaptation of Plasmodium to laboratory culture 4 The advent of present day technologies and their applications in malaria research 5 Bibliography 6 2 Exoerythrocytic development of Plasmodium parasites 9 Volker T. Heussler, Annika Rennenberg, and Rebecca R. Stanway The sporozoite s journey from the skin to the liver 10 Sporozoite invasion 14 Parasite development 15 Protein export from the parasite into the host cell 20 Parasite egress 23 The role of innate immune responses during merosome formation 26 Acknowledgments 27 Bibliography 27 3 Molecular basis of erythrocyte invasion by Plasmodium merozoites 33 Deepak Gaur, Chetan E. Chitnis, and Virander S. Chauhan The structure of the merozoite 39 The steps of erythrocyte invasion 41 Redundancy and ligand receptor interactions that mediate parasite adhesion during erythrocyte invasion 57 Signaling events during erythrocyte invasion by malaria parasites 74 Summary and conclusions 75 Bibliography 75 4 The biology of malaria transmission 87 Robert E. Sinden Purpose 87 History 87 The current research agenda 88 Biology 88 Population dynamics 106 Transmission blocking interventions 110 Bibliography 114 5 Comparative and functional genomics of malaria parasites 125 Martine M. Zilversmit, Sittiporn Pattaradilokrat, and Xin zhuan Su An Introduction to Plasmodium genomes 125 Genome structure of malaria parasites 127 From genome sequences to gene function 133 Summary 139 Acknowledgments 139 Bibliography 139 6 Gene regulation: New insights and possible intervention strategies 149 Artur Scherf, Nicholas A. Malmquist, Rafael M. Martins, Shruthi S. Vembar, and Jose Juan Lopez Rubio Introduction 149 Modes of gene regulation 150 Drug targeting 164 Perspectives 169 Bibliography 171 7 Molecular genetic approaches to malaria research 179 Brendan Elsworth, Mauro F. Azevedo, Brendan S. Crabb, and Paul R. Gilson Transfection methods 179 Genetic approaches for deriving gene function 184 Conditional knockdown of protein function 187 Protein reporters 190 Conclusions 192 Bibliography 192 8 Transcriptomics and proteomics 197 Archana P. Gupta, Zbynek Bozdech, and Peter R. Preiser Transcriptional profiling throughout the parasite life cycle 198 Transcriptional regulation 201 Transcriptional variation 205 Biological insights 208 Proteomics 208 Translational regulation 209 Conclusion 212 Bibliography 212 9 The biochemistry of Plasmodium falciparum: An updated overview 219 Hagai Ginsburg MPMP 219 Carbohydrates 219 Lipid metabolism 227 Amino acids 240 Nucleotide metabolism 252 Cofactors 256 Redox metabolism 265 Mitochondrial functions 268 Hemoglobin digestion and hemozoin production 273 Some reflections for the future 276 Bibliography 277 10 Signaling in malaria parasites 291 Pushkar Sharma and Sudhir Kumar Protein phosphorylation in Plasmodium 291 Calcium mediated signaling in Plasmodium 292 Phosphoinositide signaling and trafficking in malaria parasites 295 Cyclic nucleotide signaling in the malaria parasite 296 Future challenges 300 Bibliography 300 11 Membrane transport proteins as therapeutic targets in malaria 307 Sanjay A. Desai, Kempaiah Rayavara, Paresh Sharma, Sayeed K. Syed, Wang Nguitragool, and Praveen Balabaskaran Nina Host erythrocyte membrane: A shared ion and nutrient channel 308 Parasitophorous vacuolar membrane: Protein export and solute uptake 311 Parasite plasma membrane: Similar to other eukaryotic cells, but different 314 Digestive vacuole: A specialized lysosome equivalent in the parasite 316 Mitochondrial inner membrane: An unusual ATP synthase with uncertain function 318 Conclusions 319 Acknowledgments 319 Bibliography 319 12 The proteolytic repertoire of malaria parasites 325 Puran Singh Sijwali and Philip J. Rosenthal Aspartic proteases 325 Cysteine proteases 330 Metalloproteases 333 Serine proteases 335 Threonine proteases 338 Roles of proteases in parasite development 340 Summary and conclusions 343 Acknowledgments 343 Bibliography 343 13 Development of medicines for the control and elimination of malaria 353 Jeremy N. Burrows and Timothy N. C. Wells Targets for the development of future medicines for malaria 356 The process of drug development 359 Advances in drug development made in the 21st century 365 The global pipeline of new medicines for treating malaria 368 Medicines in the broader context of malaria eradication 370 Conclusion 377 Acknowledgments 377 Bibliography 377 14 Antimalarial drug resistance 383 Naman K. Shah and Neena Valecha Background 383 Causes of drug resistance 386 Detection of drug resistance 390 Managing drug resistance 397 Conclusion 401 Disclosures 401 Bibliography 401 Further reading 407 15 Epidemiology of Plasmodium falciparum malaria 409 Alberto L. Garcia Basteiro, Quique Bassat, and Pedro L. Alonso Burden of disease 409 Geographical distribution of the disease 411 Chain of transmission and infection cycle 413 Malaria endemicity and malaria transmission 415 Malaria elimination and eradication 423 Bibliography 424 16 Malaria pathogenesis 427 Bronner P. Goncalves, Michal Fried, and Patrick E. Duffy Malaria illness 427 Host susceptibility 439 Parasite virulence 444 Conclusions 450 Bibliography 451 17 Host genetics 465 Thomas N. Williams What evidence is there that the risk of malaria is genetically determined? 465 Identifying the genes involved 466 Why is genetic resistance important? 467 Genetic polymorphisms of the red blood cell 468 Hemoglobinopathies 474 G6PD deficiency 478 Non red blood cell polymorphisms 479 Concluding remarks 481 Bibliography 481 18 The immune response in mild and severe malaria: Two sides of the same coin 495 Michael Waisberg, Peter D. Crompton, Louis H. Miller, and Susan K. Pierce The picture of the acquisition of resistance to uncomplicated and severe malaria: Framing the questions 495 Searching for host genes that confer immune resistance to severe malaria 506 SLE susceptibility and resistance to severe malaria 507 The relationship between the pathogen environment and susceptibility to severe malaria 510 Summary 511 Acknowledgments 511 Bibliography 512 19 Progress in development of malaria vaccines 521 Chetan E. Chitnis, Deepak Gaur, and Virander S. Chauhan Immunity to malaria 521 Life cycle of malaria parasites and points of intervention with vaccines 522 Pre erythrocytic stage vaccines 524 Blood stage vaccines 526 Transmission blocking vaccines 533 Live attenuated vaccines for malaria 534 Conclusion 535 Bibliography 535 20 Plasmodium vivax: Insights on burden and pathobiology 547 Ivo Mueller, Quique Bassat, Marcus V. G. Lacerda, and Hernando A. del Portillo Burden of Plasmodium vivax infection and disease 547 Severe Plasmodium vivax malaria 550 Molecular basis of severe disease 552 Concluding remarks and outstanding research questions 558 Bibliography 558 Index 565.
  • (source: Nielsen Book Data)9781118493793 20170313
This title explores malarial biology with insights from post-genomic technologies. The book looks broadly at the disease, vectors of infection, and treatment and prevention strategies.
(source: Nielsen Book Data)9781118493793 20170313
1 online resource.
  • Section A: Engineered nanomaterials: Hazard, exposure, risk assessment 1. Bio-Nano Interactions 2. Physicochemical Characterization 3. Toxicity Tests: In Vitro and In Vivo 4. Computational Approaches 5. Exposure Assessment 6. Biomonitoring 7. Regulation and Legislation 8. Risk Assessment and Risk Management Section B: Engineered nanomaterials: Adverse effects on human health 9. Respiratory System, Part One: Basic Mechanisms 10. Respiratory System, Part Two: Allergy and Asthma 11. Cardiovascular System 12. Neurological System 13. Immune System 14. Endocrine System 15. Skin 16. Gastrointestinal System 17. Reproduction and Development 18. Genotoxicity and Cancer.
  • (source: Nielsen Book Data)9780128091999 20170410
Adverse Effects of Engineered Nanomaterials: Exposure, Toxicology, and Impact on Human Health, Second Edition, provides a systematic evaluation of representative engineered nanomaterials (ENM) of high volume production and their high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies, and the general public need to know about nanosafety. Written by leading international experts in nanotoxicology and nanomedicine, this book gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers, and patients. All chapters have been updated with new sections on the endocrine system and other organ systems. In addition, other newly added sections include introductory chapters on the physio-chemical characterization of nanomaterials and interactions between nanomaterials and biological systems, as well as a new chapter that explores risk assessment and management of nanomaterials. This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, also detailing the clinical and pathological consequences of such exposure in the human population.
(source: Nielsen Book Data)9780128091999 20170410
406 pages ; 25 cm
  • Complaint: Unaffordable healthcare
  • The age of insurance
  • The age of hospitals
  • The age of physicians
  • The age of pharmaceuticals
  • The age of medical devices
  • The age of testing and ancillary services
  • The age of contractors: Billing, coding, collections, and new medical businesses
  • The age of research and good works for profit: The perversion of a noble enterprise
  • The age of conglomerates
  • The age of healthcare as pure business
  • The age of the Affordable Care Act (ACA)
  • The high price of patient complacency
  • Doctors' bills
  • Hospital bills
  • Insurance costs
  • Drug and medical device costs
  • Bills for tests and ancillary services
  • Better healthcare in a digital age
  • Appendix A: Pricing/shopping tools
  • Appendix B: Tools for vetting hospitals
  • Appendix C: Glossary for medical bills and explanations of benefits
  • Appendix D: Tools to help you figure out whether a test or a procedure is really necessary
  • Appendix E: Templates for protest letters.
"An award-winning New York Times reporter Dr. Elisabeth Rosenthal reveals the dangerous, expensive, and dysfunctional American healthcare system, and tells us exactly what we can do to solve its myriad of problems. It is well documented that our healthcare system has grave problems, but how, in only a matter of decades, did things get this bad? Dr. Elisabeth Rosenthal doesn't just explain the symptoms; she diagnoses and treats the disease itself. Rosenthal spells out in clear and practical terms exactly how to decode medical doublespeak, avoid the pitfalls of the pharmaceuticals racket, and get the care you and your family deserve. She takes you inside the doctor-patient relationship, explaining step by step the workings of a profession sorely lacking transparency. This is about what we can do, as individual patients, both to navigate a byzantine system and also to demand far-reaching reform. Breaking down the monolithic business into its individual industries--the hospitals, doctors, insurance companies, drug manufacturers--that together constitute our healthcare system, Rosenthal tells the story of the history of American medicine as never before. The situation is far worse than we think, and it has become like that much more recently than we realize. Hospitals, which are managed by business executives, behave like predatory lenders, hounding patients and seizing their homes. Research charities are in bed with big pharmaceutical companies, which surreptitiously profit from the donations made by working people. Americans are dying from routine medical conditions when affordable and straightforward solutions exist. Dr. Rosenthal explains for the first time how various social and financial incentives have encouraged a disastrous and immoral system to spring uporganicallyin a shockingly short span of time. The system is in tatters, but we can fight back. An American Sicknessis the frontline defense against a healthcare system that no longer has our well-being at heart"-- Provided by publisher.
Medical Library (Lane)
1 online resource.
  • Basic Concepts for Statistical Modeling
  • Introduction to Simple Linear Regression Models
  • Matrix Representation of the Linear Regression Model
  • Evaluation of Partial Tests of Hypotheses in a MLRM
  • Selection of Variables in a Multiple Linear Regression Model
  • Correlation Analysis
  • Strategies for Assessing the Adequacy of the Linear Regression Model
  • Weighted Least-Squares Linear Regression
  • Generalized Linear Models
  • Poisson Regression Models for Cohort Studies
  • Logistic Regression in Case-Control Studies
  • Regression Models in a Cross-Sectional Study
  • Solutions to Practice Exercises.