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Book
1 online resource.
  • List of Contributors xi Preface xv Acknowledgments xvii Section 1 Introduction to Biosensors, Recognition Elements, Biomarkers, and Nanomaterials 1 1 General Introduction to Biosensors and Recognition Receptors 3Frank Davis and Zeynep Altintas 1.1 Introduction to Biosensors 3 1.2 Enzyme- Based Biosensors 4 1.3 DNA- and RNA-Based Biosensors 5 1.4 Antibody-Based Biosensors 7 1.5 Aptasensors 8 1.6 Peptide-Based Biosensors 10 1.7 MIP-Based Biosensor 11 1.8 Conclusions 12 References 13 2 Biomarkers in Health Care 17Adama Marie Sesay, Pirkko Tervo, and Elisa Tikkanen 2.1 Introduction 17 2.2 Biomarkers 18 2.2.1 Advantage and Utilization of Biomarkers 18 2.2.2 Ideal Characteristics of Biomarkers 19 2.3 Biological Samples and Biomarkers 20 2.4 Personalized Health and Point-of-Care Technology 22 2.5 Use of Biomarkers in Biosensing Technology 24 2.6 Biomarkers in Disease Diagnosis 26 2.7 Conclusions 29 References 30 3 The Use of Nanomaterials and Microfluidics in Medical Diagnostics 35Jon Ashley and Yi Sun 3.1 Introduction 35 3.2 Nanomaterials in Medical Diagnostics (Bottom-Up Approach) 36 3.2.1 Carbon Nanomaterials 37 3.2.2 Metallic Nanoparticles 39 3.2.2.1 Quantum Dots 39 3.2.2.2 Magnetic Nanoparticles (Fe2O3, FeO, and Fe3O4) 41 3.2.2.3 Gold Nanoparticles 41 3.2.2.4 Silver Nanoparticles 42 3.2.2.5 Nanoshells 42 3.2.2.6 Nanocages 43 3.2.2.7 Nanowires 43 3.2.3 Polymer-Based Nanoparticles 44 3.3 Application of Microfluidic Devices in Clinical Diagnostics (Top-Down Approach) 45 3.3.1 Unique Features of Microfluidic Devices 45 3.3.2 Applications of Microfluidic Devices in Medical Diagnostics 46 3.3.2.1 Types of Microfluidic POC Devices 47 3.3.2.2 Benchtop Microfluidic Instruments 47 3.3.2.3 Small, Lightweight Microfluidic Devices 49 3.3.2.4 Simple Un-instrumented Microfluidic Systems 50 3.4 Integration of Microfluidics with Nanomaterials 52 3.5 Future Perspectives of Nanomaterial and Microfluidic-Based Diagnostics 53 References 54 Section 2 Biosensor Platforms for Disease Detection and Diagnostics 59 4 SPR-Based Biosensor Technologies in Disease Detection and Diagnostics 61Zeynep Altintas and Wellington M. Fakanya 4.1 Introduction 61 4.2 Basic Theoretical Principles 63 4.3 SPR Applications in Disease Detection and Diagnostics 66 4.3.1 SPR Biosensors in Cancer Detection 66 4.3.2 SPR Sensors in Cardiac Disease Detection 68 4.3.3 SPR Sensors in Infectious Disease Detection 71 4.4 Conclusions 72 References 74 5 Piezoelectric-Based Biosensor Technologies in Disease Detection and Diagnostics 77Zeynep Altintas and Noor Azlina Masdor 5.1 Introduction 77 5.2 QCM Biosensors 78 5.3 Disease Diagnosis Using QCM Biosensors 80 5.3.1 Cancer Detection Using QCM Biosensors 82 5.3.2 Cardiovascular System Disorder Detection Using Biosensors 85 5.3.3 Pathogenic Disease Detection Using QCM Biosensors 88 5.4 Conclusions 90 References 91 6 Electrochemical-Based Biosensor Technologies in Disease Detection and Diagnostics 95Andrea Ravalli and Giovanna Marrazza 6.1 Introduction 95 6.2 Electrochemical Biosensors: Definitions, Principles, and Classifications 96 6.3 Biomarkers in Clinical Applications 102 6.3.1 Electrochemical Biosensors for Tumor Markers 102 6.3.2 Electrochemical Biosensors for Cardiac Markers 110 6.3.3 Electrochemical Biosensors for Autoimmune Disease 115 6.3.4 Electrochemical Biosensors for Autoimmune Infectious Disease 116 6.4 Conclusions 118 References 118 7 MEMS-Based Cell Counting Methods 125Mustafa Kangul, Eren Aydin, Furkan Gokce, Ozge Zorlu, Ebru Ozgur, and Haluk Kulah 7.1 Introduction 125 7.2 MEMS-Based Cell Counting Methods 126 7.2.1 Optical Cell Counting Methods 126 7.2.1.1 Quantification of the Cells by Detecting Luminescence 127 7.2.1.2 Quantification of the Cells via High-Resolution Imaging Techniques 130 7.3 Electrical and Electrochemical Cell Counting Methods 131 7.3.1 Impedimetric Cell Quantification 133 7.3.2 Voltammetric and Amperometric Cell Quantification 135 7.4 Gravimetric Cell Counting Methods 136 7.4.1 Deflection-Based Cell Quantification 136 7.4.2 Resonant-Based Cell Quantification 138 7.4.2.1 Theory of the Resonant-Based Sensors 138 7.4.2.2 Actuation and Sensing Methods of Resonators in MEMS Applications 140 7.4.2.3 Resonator Structure Types Used for Cell Detection Applications 145 7.5 Conclusion and Comments 149 References 151 8 Lab-on-a-Chip Platforms for Disease Detection and Diagnosis 155Ziya Isiksacan, Mustafa Tahsin Guler, Ali Kalantarifard, Mohammad Asghari, and Caglar Elbuken 8.1 Introduction 155 8.2 Continuous Flow Platforms 156 8.3 Paper-Based LOC Platforms 161 8.4 Droplet-Based LOC Platforms 166 8.5 Digital Microfluidic-Based LOC Platforms 169 8.6 CD-Based LOC Platforms 172 8.7 Wearable LOC Platforms 174 8.8 Conclusion and Outlook 176 References 177 Section 3 Nanomaterial's Applications in Biosensors and Diagnostics 183 9 Applications of Quantum Dots in Biosensors and Diagnostics 185Zeynep Altintas, Frank Davis, and Frieder W. Scheller 9.1 Introduction 185 9.2 Quantum Dots: Optical Properties, Synthesis, and Surface Chemistry 186 9.3 Biosensor Applications of QDs 187 9.4 Other Biological Applications of QDs 191 9.5 Water Solubility and Cytotoxicity 194 9.6 Conclusion 196 References 197 10 Applications of Molecularly Imprinted Nanostructures in Biosensors and Diagnostics 201Deniz Aktas-Uygun, Murat Uygun, and Sinan Akgol 10.1 Introduction 201 10.2 Molecular Imprinted Polymers 202 10.3 Imprinting Approaches 204 10.4 Molecularly Imprinted Nanostructures 205 10.5 MIP Biosensors in Medical Diagnosis 207 10.6 Diagnostic Applications of MIP Nanostructures 210 10.7 Conclusions 212 References 213 11 Smart Nanomaterials: Applications in Biosensors and Diagnostics 219Frank Davis, Flavio M. Shimizu, and Zeynep Altintas 11.1 Introduction 219 11.2 Metal Nanoparticles 221 11.3 Magnetic Nanoparticles 226 11.4 Carbon Nanotubes 231 11.5 Graphene 235 11.6 Nanostructured Metal Oxides 242 11.7 Nanostructured Hydrogels 247 11.8 Nanostructured Conducting Polymers 254 11.9 Conclusions and Future Trends 260 References 262 12 Applications of Magnetic Nanomaterials in Biosensors and Diagnostics 277Zeynep Altintas 12.1 Introduction 277 12.2 MNP-Based Biosensors for Disease Detection 279 12.3 MNPs in Cancer Diagnosis and Therapy 284 12.4 Cellular Applications of MNPs in Biosensing, Imaging, and Therapy 289 12.5 Conclusions 290 References 291 13 Graphene Applications in Biosensors and Diagnostics 297Adina Arvinte and Adama Marie Sesay 13.1 Introduction 297 13.2 Graphene and Biosensors 298 13.2.1 Structure 298 13.2.2 Preparation 299 13.2.3 Properties 301 13.2.4 Commercialization in the Field of Graphene Sensors 302 13.2.5 Latest Developments in Graphene-based Diagnosis 303 13.3 Medical Applications of Graphene 303 13.3.1 Electrochemical Graphene Biosensors for Medical Diagnostics 304 13.3.1.1 Glucose Detection 304 13.3.1.2 Cysteine Detection 307 13.3.1.3 Cholesterol Detection 309 13.3.1.4 Hydrogen Peroxide (H2O2) 310 13.3.1.5 Glycated Hemoglobin 312 13.3.1.6 Neurotransmitters 312 13.3.1.7 Amyloid-Beta Peptide 315 13.3.2 Electrochemical Graphene Aptasensors 316 13.3.2.1 Nucleic Acids 316 13.3.2.2 Cancer Cell 318 13.3.3 Optical Graphene Sensors for Medical Diagnostics 319 13.4 Conclusions 322 Acknowledgments 322 References 322 Section 4 Organ-Specific Health Care Applications for Disease Cases Using Biosensors 327 14 Optical Biosensors and Applications to Drug Discovery for Cancer Cases 329Zeynep Altintas 14.1 Introduction 329 14.2 Biosensor Technology and Coupling Chemistries 332 14.3 Optical Biosensors for Drug Discovery 335 14.4 Computational Simulations and New Approaches for Drug-Receptor Interactions 341 14.5 Conclusions 343 References 344 15 Biosensors for Detection of Anticancer Drug-DNA Interactions 349Arzum Erdem, Ece Eksin, and Ece Kesici 15.1 Introduction 349 15.2 Electrochemical Techniques 351 15.3 Optical Techniques 356 15.4 Electrochemical Impedance Spectroscopy Technique 358 15.5 QCM Technique 360 15.6 Conclusions 361 Acknowledgments 361 References 361 Index.
  • (source: Nielsen Book Data)9781119065012 20171204
Provides a broad range of information from basic principles to advanced applications of biosensors and nanomaterials in health care diagnostics This book utilizes a multidisciplinary approach to provide a wide range of information on biosensors and the impact of nanotechnology on the development of biosensors for health care. It offers a solid background on biosensors, recognition receptors, biomarkers, and disease diagnostics. An overview of biosensor-based health care applications is addressed. Nanomaterial applications in biosensors and diagnostics are included, covering the application of nanoparticles, magnetic nanomaterials, quantum dots, carbon nanotubes, graphene, and molecularly imprinted nanostructures. The topic of organ-specific health care systems utilizing biosensors is also incorporated to provide deep insight into the very recent advances in disease diagnostics. Biosensors and Nanotechnology: Applications in Health Care Diagnostics is comprised of 15 chapters that are presented in four sections and written by 33 researchers who are actively working in Germany, the United Kingdom, Italy, Turkey, Denmark, Finland, Romania, Malaysia and Brazil. It covers biomarkers in healthcare; microfluidics in medical diagnostics; SPR-based biosensor techniques; piezoelectric-based biosensor technologies; MEMS-based cell counting methods; lab-on-chip platforms; optical applications for cancer cases; and more. Discusses the latest technology and advances in the field of biosensors and their applications for healthcare diagnosticsParticular focus on biosensors for cancerSummarizes research of the last 30 years, relating it to state-of-the-art technologies Biosensors and Nanotechnology: Applications in Health Care Diagnostics is an excellent book for researchers, scientists, regulators, consultants, and engineers in the field, as well as for graduate students studying the subject.
(source: Nielsen Book Data)9781119065012 20171204
Book
1 online resource.
Book
1 online resource (852 p.) : ill.
"This unique volume focuses on the "tools" of medical statistics. It contains over 500 concepts or methods, all of which are explained very clearly and in detail. Each chapter focuses on a specific field and its applications. There are about 20 items in each chapter with each item independent of one another and explained within one page (plus references). The structure of the book makes it extremely handy for solving targeted problems in this area. As the goal of the book is to encourage students to learn more combinatorics, every effort has been made to provide them with a not only useful, but also enjoyable and engaging reading. This handbook plays the role of "tutor" or "advisor" for teaching and further learning. It can also be a useful source for "MOOC-style teaching"."--Publisher's website.
Book
1 online resource : illustrations.
Hemocompatibility of Biomaterials for Clinical Applications: Blood-Biomaterials Interactions summarizes the state-of-the-art on this important subject. The first part of the book reviews the latest research on blood composition and response, mechanisms of coagulation, test standards and methods. Next, the book assesses techniques for modifying biomaterial surfaces and developing coatings to improve hemocompatibility. In the final sections, users will find discussions on ways to improve the hemocompatibility of particular classes of biomaterials and a review of methods for improving medical devices.
Book
1 online resource (380 p.) : ill. (some col.).
"This book is a comprehensive guide for all tissue bank operators to screen, procure and process amniotic membrane for clinical application. The amnion comes close to being the ideal biological membrane or dressing — readily available, inexpensive to procure and process. Its basic science is discussed in detail — anatomy, biological and biomechanical properties. It can be procured from the placenta in normal vaginal deliveries and from Caesarean Sections. Processing is by freeze-drying or by air-drying process with sterilisation using gamma irradiation. The product has low antigenicity, has anti-microbial properties with ability to enhance epithelisation with marked relief of pain. It is useful as a dressing for wounds — flap wounds, burn wounds, injury wounds, diabetic ulcers, leprous ulcers and post-surgery wounds and post-radiation wounds. It is also used as a biological scaffold for cells in tissue engineering. Its ophthalmic applications include treatment of corneal ulcers and conjunctival tumours. Oral uses include gingiva depigmentation and periodontal regeneration."--Publisher's website.
Book
xvii, 252 pages ; 24 cm.
  • Islamic Bioethics: Infrastructure and Capacity Building (A Bagheri)-- Islamic Ethics: Sources, Methodology and Application (T Ramadan)-- Principles of Islamic Bioethics (E Moosa)-- Challenges in Inter-Religious Dialogue in Bioethics (O Bakar)-- What Islamic Bioethics Can Offer to the Global Bioethics (A Daar et al.)-- Challenges in Islamic Bioethics (K Aali et al.)-- Defining the Pedagogical Parameters of Islamic Bioethics (A Sachedina)-- Doctor-Patient Relationship in Islamic Context (M Al Bar & H Chamsi-Pasha)-- Islamic Perspective on Brain Death and Organ Transplantation (M Ebrahim)-- Environmental Ethics in Islam (A Baharuddin)-- The Stem Cell Debate in Islamic Bioethics (I Ilkilic)-- Animal Rights in Islam (B Larijani et al.)-- Gender, Sexuality and Transgender in Islamic Bioethics (I Mattson)--.
  • (source: Nielsen Book Data)9781783267491 20171211
Islamic Bioethics presents a wide variety of perspectives and debates on how Islamic societies deal with the ethical dilemmas raised by biomedicine and new technologies. The book is a 'constructive dialogue' between contributors selected from a multidisciplinary group of Muslim and non-Muslim scholars from different Islamic countries. The 13 chapters illuminate the diversity and complexity of the issues discussed in Islamic bioethics and pave the way to a better understanding of Islamic bioethics and dialogue in the global bioethics community. The chapters take both theoretical and practical approaches to the topic, and each covers an emerging issue in Islamic bioethics.This book will be useful for academics and professional institutions in both Islamic and non-Islamic countries, and will be instrumental in providing researchers, scholars, students, policymakers and medical professionals with access to the latest issues and debates related to Islamic bioethics.
(source: Nielsen Book Data)9781783267491 20171211
Green Library
Book
6 volumes ; 25 cm
  • al-Mujallad al-awwal. al-Maqālah al-ūlá : fī khamsah wa-ʻishrīn bāban, al-maqālah al-thāniyah : Fī sittat ʻashar bābān, al-maqālah al-thālithah : fī ṣifat al-aʻḍāʼ al-murakkabah, al-maqālah al-rābiʻah : Dhikr al-quwá wa-al-afʻāl wa-al-arwāḥ
  • al-mujallad al-thānī. al-maqālah al-khāmisah : fī jumlat al-kalām ʻalá al-umūr allatī laysat bi-ṭabīʻīyah, al-maqālah al-sādisah : Fī al-umūr al-khārijah ʻan al-amr al-ṭabīʻī, al-maqālah al-sābiʻah : Fī maʻrifat al-dalāʼil al-ʻāmmīyah ʻalá al-amrāḍ wa-al-ʻilal
  • al-mujallad al-thālith. al-maqālah al-thāminah : Fī al-istidlāl ʻalá al-amrāḍ al-ẓāhirah lil-ḥiss wa-asbābihā, al-maqālah al-tāsiʻah : Fī al-istidlāl ʻalá ʻilal al-aʻḍāʼ al-bāṭinah, al-maqālah al-ʻāshirah : Wa-hiyá ākhir al-niṣf al-awwal min kitāb Kāmil al-ṣināʻah
  • al-mujallad al-rābiʻ. al-maqālah al-ḥādiyat ʻashar : Fī ḥifẓ al-ṣiḥḥah, al-maqālah al-thāniyat ʻashar : Fī mudāwāt al-amrāḍ bi-al-adwiyah al-mufradah, al-maqālah al-thālithat ʻashar : Fī mudawāt al-ḥummīyāt wa-al-awrām
  • al-mujallad al-khāmis. al-maqālah al-rābiʻat ʻashar : Fī al-ʻilal wa-al-aʻrāḍ al-ʻāriḍah fī saṭḥ al-badan, al-maqālah al-khāmisat ʻashar : Fī amrāḍ al-raʼs, al-maqālah al-sādisat ʻashar : Fī mudāwāt al-ʻilal al-ʻāriḍah fī ālat al-tanaffus, al-maqālah al-sābiʻat ʻashar : Fī mudāwāt al-ʻilal al-ʻāriḍah fī ālat al-ghidhāʼ
  • al-mujallad al-sādis. al-maqālah al-thāminat ʻashar : Fī mudāwāt al-ʻilal al-ʻāriḍah li-ālāt al-tanāsul wa-al-mafāṣil wa-al-ghidhāʼ, al-maqālah al-tāsiʻat ʻashar : Fī ʻilāj al-amrāḍ allatī takūnu bi-al-yad, al-maqālah al-ʻishrūn : Fī al-adwiyah al-murakkabah al-madhkūrah fī hādhā al-kitāb.
SAL3 (off-campus storage)
Book
xiii, 216 pages : illustrations, map ; 24 cm
Green Library
Book
1 online resource : illustrations
Book
1 online resource.
  • Prologue: Crescit Eundo: Nanotechnologies in Preventive and Regenerative Medicine by Uskokovic and Uskokovic 1. Nanotechnologies for Early Diagnosis, in situ Disease Monitoring and Prevention 1.1. Fluorescent Nanodiamond for Tracking the Engraftment and Repair of Lung Stem Cells by Wu, Chiu and Yu 1.2. Antiretroviral drug-loaded nanoparticles for preventing HIV transmission by Cautela, Sarmento and das Neves 1.3. Surface enhanced Raman scattering methods for diagnosis of infectious diseases by Catala, Pazos-Perez, Guerrini, Alvarez-Puebla 1.4. Radiolabeled functional nanoparticles in preventive and regenerative medicine by Vranjes-Duric and Ignjatovic 2. Nanotechnologies for Tissue Engineering and Regeneration 2.1. Nanoengineered/Nanopatterned Materials forã Cell and Tissue Guidance by Ventre, Coppola, Iannone and Netti 2.2. Microneedles in Nanomedicine Delivery by Tekko, ã Larraneta, Rodgers, Scott, Kissenpfennig and Donnelly 2.3. Nano-Engineered Titania Nanotube Arrays for Localized Drug Delivery and Enhanced Osseointegration by Maher and Losic 2.4. Nanostructured scaffolds made of self-assembled proteins by George and Ramachandran 3. Understanding and Utilizing the Biomolecule/Nanosystems Interface 3.1. Biomolecule immobilization and delivery strategies for controlling immune cell response by Chen and Liu 3.2. Nanoproteomics Approaches in Biomarker Discovery. The critical role of protein corona on nanoparticles as drug carriers by Megido, Diez and Fuentes 3.3. Soft Materials and Coatings For Controlled Drug Release by Fager and Olsson 3.4. Dual Function Nanoconjugates for Biomedical Imaging and Targeted Drug Delivery by Gesner and Mathur 4. 3D Printing: Prospects and Challenges 4.1. Smart 3D printing and nanomaterials for tissue regeneration by Martins, Ferreira, Ezazi, Hirvonen and Santos 4.2. Nanomaterials in 3D Bioprinting - Current Approaches and Future Possibilities by Thrivikraman, Franca, Athirasala, Tahayeri and Bertassoni 5. Environmental Assessment of Medical Nanotechnologies 5.1. What we have learnt from the life cycle impacts of nano silver products by Hicks 6. Targeted and Theranostic Applications for Nanotechnologies in Medicine 6.1. Multifunctional magnetic nanoparticles for cancer treatment by Setua, Jaggi, Yallapu and Chauhan 6.2. Magnetic nanoparticles surface-engineered cells for regenerative and bioanalytical applications by Danilushkina, Lee, Choi and Fakhrullin 6.3. Nanostructured calcium phosphate in theranostic nanomedicine by Esposti, Tampieri and Iafisco 6.4. Nanoparticles for Brain Tumor Targeting by Shevtsov and Multhoff Epilogue: Nanotechnologies in Preventive and Regenerative Medicine: Quo Vadis, Domine? By Uskokovic and Uskokovic.
  • (source: Nielsen Book Data)9780323480635 20171211
Nanotechnologies in Preventative and Regenerative Medicine demonstrates how control at the nanoscale can help achieve earlier diagnoses and create more effective treatments. Chapters take a logical approach, arranging materials by their area of application. Biomaterials are, by convention, divided according to the area of their application, with each chapter outlining current challenges before discussing how nanotechnology and nanomaterials can help solve these challenges This applications-orientated book is a valuable resource for researchers in biomedical science who want to gain a greater understanding on how nanotechnology can help create more effective vaccines and treatments, and to nanomaterials researchers seeking to gain a greater understanding of how these materials are applied in medicine.
(source: Nielsen Book Data)9780323480635 20171211
Book
1 online resource.
  • 1. Fundamentals of protein and cell interactions in biomaterials Part 1 Proteins in biomaterials mimicking the extra cellular matrix 2. Extracellular matrix constitution and function for tissue regeneration and repair 3. Surface functionalization of biomaterials for tissue regeneration and repair 4. Bioengineered peptide biomaterials for tissue regeneration and repair Part 2 Protein-based biomaterials for tissue regeneration and repair 5. Collagen-based biomaterials for tissue regeneration and repair 6. Fibrin-Based Biomaterials for tissue regeneration and repair 7. Fibrous protein-based biomaterials (silk, keratin, elastin and resilin proteins) for tissue regeneration and repair Part 3 Processing of peptides and proteins as biomaterials 8. Fabrication of nanofibres and nanotubes for tissue regeneration and repair 9. Peptide and protein printing for tissue regeneration and repair Part 4 Bioengineering of proteins and peptides 10. Self-assembled peptides for tissue regeneration and repair 11. Collagen-like materials for tissue regeneration and repair 12. Elastin-like materials for tissue regeneration and repair 13. Mussel inspired Biomaterials (bioadhesives) for tissue regeneration and repair Part 5 Antimicrobial peptides (AMP) based biomaterial 14. AMP biomaterial coatings for tissue regeneration and repair 15. AMP as hydrogels for tissue regeneration and repair.
  • (source: Nielsen Book Data)9780081008034 20171204
Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology.
(source: Nielsen Book Data)9780081008034 20171204
Book
1 online resource
  • Part I - Ethical, Regulatory and Legal Issues Part II - Biostatistics and Epidemiology Part III - Technology Transfer, Protocol Development, and Sources of Funding Support for Research Part IV - Clinical Research Infrastructure.
  • (source: Nielsen Book Data)9780128499054 20171211
Principles and Practice of Clinical Research, Fourth Edition has been thoroughly revised to provide a comprehensive look at both the fundamental principles and expanding practice of clinical research. New to this edition of this highly regarded reference, authors have focused on examples that broadly reflect clinical research on a global scale while including a discussion of international regulations, studies, and implications. In addition to key topics such as bioethics, clinical outcome data, cultural diversity, protocol guidelines, and "omic platforms, this edition contains new chapters devoted to electronic health records and information resources for clinical researchers, as well as the many opportunities associated with big data. Covering a vast number of topics and practical advice for both novice and advanced clinical investigators, this book is a highly relevant and essential resource for all those involved in conducting research.
(source: Nielsen Book Data)9780128499054 20171211
Book
1 online resource (305 p.) : ill. (chiefly col.).
  • Engineering approaches for creating skeletal muscle / Caleb Vogt, Mitchell Tahtinen & Feng Zhao
  • Characterization of biomaterial patches as fetal surgery implants / Rigwed Tatu & Chia-Ying Lin
  • Three-dimensional bioprinting for cartilage regeneration / Hailin Zhu, Hui Gong & Harry Huimin Chen
  • Directed differentiation of human pluripotent stem cells for therapeutic applications / Lauren N. Randolph, Evan B. Witmer & Xiaojun Lian
  • Magnetic nanohybrids for magnetic resonance imaging and phototherapy
  • Applications / Muhammad Zubair Iqbal & Aiguo Wu
  • Plasmonic nanoparticles application in bio-sensor and bio-imaging / Mengmeng Liu
  • Delivering nanoparticles to cancer cells / Ronald L. Huston
  • Multifunctional nanomaterials for cancer theranostics / Shun Shen.
"This book provides a comprehensive overview of current achievements in biomedical applications of nanotechnology, including stem cell based regenerative medicine, medical imaging, cell targeting, drug delivery, and photothermal/photodynamic cancer therapy. New approaches in early cancer diagnosis and treatment are introduced with extensive experimental results. In particular, some novel materials have been synthesized with new properties that are most effective in cancer therapy. Some of the key issues are also addressed with these recent discoveries such as bio safety and bio degradability, that are essential in the success of nano medicine. An important aspect of this book is the introduction of nanotechnology to the medical communities that are searching for new treatments of cancer, therefore breaking barriers between the physical and medical sciences so that more MDs will be able to appreciate the new discoveries and establishments in medical diagnoses and therapies capable of tackling major clinical issues."--Publisher's website.
Book
1 online resource : text file, PDF.
  • 1 Empowering Clinician-Scientists in the Information Age of Omics and Data Science PAMELA A. TAMEZ AND MARY B. ENGLER 2 Making Data Matter: Identifying Care Opportunities for US Healthcare Transformation MARK A. CARON 3 Turning Data into Enhanced Value for Patients KYUN HEE (KEN) LEE 4 Data Analytics for the Clinical Researcher MINJAE KIM 5 Intelligent Healthcare: The Case of the Emergency Department SHIVARAM POIGAI ARUNACHALAM, MUSTAFA SIR, AND KALYAN S. PASUPATHY 6 Network Analytics to Enable Decisions in Healthcare Management UMA SRINIVASAN, ARIF KHAN, AND SHAHADAT UDDIN 7 Modeling and Analysis of Behavioral Health Data Using Graph Analytics ROSE YESHA AND ARYYA GANGOPADHYAY 8 The Heart of the Digital Workplace: Intelligent Search Moves the Measure from Efficiency to Proficiency for a Fortune 50 Healthcare Company JAY LIEBOWITZ AND DIANE BERRY 9 The Promise of Big Data Analytics-Transcending Knowledge Discovery through Point-of-Care Applications LAVI OUD 10 Predictive Analytics and Machine Learning in Medicine L. NELSON SANCHEZ-PINTO AND MATTHEW M. CHURPEK 11 High-Dimensional Models and Analytics in Large Database Applications MICHAEL BRIMACOMBE 12 Learning to Extract Actionable Evidence from Medical Insurance Claims Data JIESHI CHEN AND ARTUR DUBRAWSKI 13 The Role of Unstructured Data in Healthcare Analytics\ AMANDA DAWSON AND SERGEI ANANYAN Index.
  • (source: Nielsen Book Data)9781498779937 20171218
This book shows healthcare professionals how to turn data points into meaningful knowledge upon which they can take effective action. Actionable intelligence can take many forms, from informing health policymakers on e ective strategies for the population to providing direct and predictive insights on patients to healthcare providers so they can achieve positive outcomes. It can assist those performing clinical research where relevant statistical methods are applied to both identify the efficacy of treatments and improve clinical trial design. It also benefits healthcare data standards groups through which pertinent data governance policies are implemented to ensure quality data are obtained, measured, and evaluated for the benefit of all involved. Although the obvious constant thread among all of these important healthcare use cases of actionable intelligence is the data at hand, such data in and of itself merely represents one element of the full structure of healthcare data analytics. This book examines the structure for turning data into actionable knowledge and discusses: * The importance of establishing research questions * Data collection policies and data governance * Principle-centered data analytics to transform data into information * Understanding the "why" of classified causes and effects * Narratives and visualizations to inform all interested parties Actionable Intelligence in Healthcare is an important examination of how proper healthcare-related questions should be formulated, how relevant data must be transformed to associated information, and how the processing of information relates to knowledge. It indicates to clinicians and researchers why this relative knowledge is meaningful and how best to apply such newfound understanding for the betterment of all.
(source: Nielsen Book Data)9781498779937 20171218
Book
1 online resource.
  • Front Cover; #x93; Advances in Ceramic Biomaterials#x93; ; Copyright Page; Contents; List of Contributors; Preface; Acknowledgments; I. An Overview of Biomedical Grade Ceramic Materials; 1 Materials for hard tissue applications: An overview; Chapter Outline; 1.1 Introduction: Hard tissues and how to replace them; 1.2 Materials for hard tissue applications; 1.2.1 Dental applications; 1.2.1.1 Materials for dental implants; 1.2.1.2 Materials for crowns and structures; 1.2.1.3 Materials for esthetics; 1.2.1.4 Materials for caries filling; 1.2.2 Orthopedic applications; 1.2.2.1 Alumina
  • 1.2.2.2 Zirconia (3Y-TZP)1.2.2.3 Composites; 1.2.2.4 Materials in development; 1.2.3 Ceramics for bone repair; 1.2.3.1 Sintered calcium orthophosphates; 1.2.3.2 Bone cements; 1.2.3.3 Bioactive glasses and glass ceramics; 1.2.3.4 Ceramic-polymer composites; 1.3 Concluding remarks; References; 2 Types of ceramics: Material class; Chapter Outline; 2.1 Active oxides; 2.1.1 Introduction; 2.1.2 CaP-based systems; 2.1.2.1 Pure and substituted HA and related apatite compounds; Well-crystallized apatites; Nanocrystalline apatites; 2.1.2.2 Associations with other inorganic compounds
  • 2.5 Glass ceramics and bioactive glass ceramics2.6 Glass-ionomer cements; 2.6.1 Introduction; 2.6.2 The chemistry of GICs; 2.6.3 Glass compositions to form GICs; 2.6.3.1 Aluminosilicate glasses; 2.6.3.2 Aluminoborate glasses; 2.6.3.3 Zinc silicate glasses; 2.6.4 Key factors affecting the properties of GICs; 2.6.4.1 Al2O3/SiO2 ratio in the glass; 2.6.4.2 Phosphorus content in the glass; 2.6.4.3 F− content in the glass; 2.6.4.4 Na+ content in the glass; 2.6.4.5 Glass reactivity; Heat treatment; Acid washing; 2.6.4.6 Particle size; 2.6.5 Fluoride release and recharge ability
  • 2.6.6 Antimicrobial effectiveness2.7 Magnetic ceramic materials in medicine; 2.8 Conclusion; References; Further reading; 3 Assessment of mechanical properties of ceramic materials; Chapter Outline; 3.1 Introduction to mechanical properties; 3.1.1 Bioceramics; 3.1.2 Fracture of ceramics; 3.1.3 Weibull statistics of the strength; 3.1.4 Subcritical crack growth; 3.1.5 KIC and curve R-behavior of ceramics; 3.1.6 Mechanisms of increase in fracture toughness; 3.2 Bioactive glasses and glass ceramics; 3.3 Calcium phosphates (CaP) and CaP composites; 3.4 Calcium phosphate cements