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1 online resource.
  • 1 Computational Approaches in Biomedical Nanoengineering: An Overview 1 Ayesha Sohail and Zhiwu Li 1.1 Introduction 1 1.2 Nanobiotechnology in Disease Diagnosis 3 1.2.1 Application of Nanoparticles for Discovery of Biomarkers 4 1.2.2 Nanotechnology-based Biochips and Microarrays 5 1.2.3 Detection via Semiconductor Nanocrystals 5 1.2.4 Nanoscale Sensor Technologies for Disease Detection via Volatolomics 6 1.3 Nanobiotechnology in Treatment 8 1.4 Nanobiotechnology in Target-specific Drug Delivery 8 1.4.1 Future of Giant Magnetoresistance (GMR) Sensors: An Alternative to the Traditional Use of Enzymes, Radioisotopes, or Fluorescent Tagging 8 1.4.2 Drug Delivery via Hyperthermia 9 1.5 Computational Approaches 10 1.5.1 ComputationalModel of Drug Targeting 11 1.5.2 ComputationalModel of Electrical Activity in Cardiac Tissue 11 1.5.3 ComputationalModel of Fringe Field Effect 13 1.5.4 ComputationalModel of Nanoparticle Hyperthermia 14 1.5.5 Hybrid Models in Computational Nanobiotechnology 15 1.5.6 Machine Learning for Detection and Diagnosis of Diseases 15 Machine Learning and Recent Bioinformatics: Case Studies 16 Current Challenges 17 References 18 2 Nanotechnology Applications - The Future Arrived Suddenly 23 Manuel Alberto M. Ferreira and Jose A. Filipe 2.1 Introduction 23 2.2 Nanotechnology: A Brief Approach 24 2.3 Nanopanels: A Success of Nanotechnology in Industry 28 2.4 Nanoelectronics: Improving the Life Standard 30 2.5 Nanotechnology in Medicine: Friendly Efficient Healthcare 32 2.6 Ethics and Nanotechnology 34 2.7 Concluding Remarks 39 References 40 3 Biosynthesized Nanobullets for Microbes and Biofilms 43 Lubna Sherin, Zareen Arshad, and Tehniyat Liaqat 3.1 Introduction 43 3.2 Biosynthesized Nanoparticles 44 3.2.1 Microorganisms 45 3.2.2 Algae 47 3.2.3 Fungi 48 3.2.4 Yeasts 50 3.2.5 Actinomycetes 51 3.2.6 Plants 52 3.3 Antimicrobial Potential of Nanoparticles 55 3.4 Mechanism of Antimicrobial Action of Inorganic NPs 57 3.4.1 Interaction of NPs with Cell Membrane 57 3.4.2 Oxidative Stress 58 3.4.3 NP Interaction with Proteins 59 3.5 Reactivity of NPs against Biofilms 59 3.6 Nanosilver as Efficient Antimicrobial Agent 63 3.7 NPs as Efficient Carrier of Traditional Antibiotics 65 3.8 Real-life Applications of Antimicrobial Nanomaterials 68 3.8.1 Wound Dressing Materials 68 3.8.2 Tissue Scaffolds 69 3.8.3 Disinfecting Medical Implant and Devices 70 3.8.4 Antimicrobial Food Packaging 70 3.8.5 Water Disinfection 72 3.8.6 Application in Personal Care Products 73 3.9 Conclusion and Future Prospects 73 References 74 4 The Physics of Nanosensor Systems in Medicine and the Development of Physiological Monitoring Equipment 89 Robert Splinter 4.1 Introduction 89 4.1.1 Biological Sensing 89 4.1.2 Applications 92 4.2 Sensing Technology 93 4.2.1 Sensing Targets 93 4.2.2 Static vs Dynamic Events/Sensing 93 4.2.3 Mechanism of Action (MoA) for Sensing 94 Chemical 95 Electronic 95 Mechanical 98 Optical 100 Single-molecule Detection/Tagging Sensor Design 100 Thermal/Energetic 101 4.3 Sensor Design 102 4.3.1 Ion-sensitive Solid-state Field-Effect Transistor (ISFET)/ChemFET 102 4.3.2 Carbon Nanotube Field-Effect Transistor (CNTFET) 104 Computational Analysis of Nanosensor Detection 106 4.4 Discussion 107 References 108 5 Nonlinear Multiphysical Laminar Nanofluid Bioconvection Flows: Models and Computation 113 O. Anwar Beg 5.1 Introduction 113 5.1.1 Bioconvection 113 Bioconvection Lewis Number 115 Bioconvection Peclet Number 116 5.1.2 Nanofluids 116 Buongiorno MIT Model 117 Nanofluid Heat Capacity Ratio 118 Brownian Motion Parameter 118 Thermophoresis Parameter 119 Tiwari-Das Model 119 5.2 Numerical and Semi-numericalMethods 121 5.2.1 Overview of Numerical/Semi-numericalMethods 121 5.2.2 Finite Element Methods 122 5.2.3 Finite Difference Methods 123 Keller Box Method 123 Nakamura Tridiagonal Scheme 124 5.2.4 Adomian Decomposition Method 124 5.2.5 Gauss-Lobatto Quadrature 126 5.3 Multiphysical Nanofluid Bioconvection BVPs 126 5.3.1 Von Karman Swirl Bioconvection Nanofluid Model 126 5.4 Conclusions/Future Directions in Nanofluid Bioconvection 140 References 140 6 Exploring Nanotechnology Applications in Medicine 147 Stefano Nobile and Lucio Nobile 6.1 Introduction 147 6.2 Nanotechnology in Medicine 148 6.2.1 The Nervous System 149 6.2.2 Cancer 154 6.2.3 Infectious Diseases 154 6.2.4 Cardiovascular Diseases 155 6.2.5 Pneumology 155 6.3 Bone Tissue Engineering 156 6.3.1 Components of the Skeletal System 156 6.3.2 Scaffolds 159 6.3.3 Bioactive Nanoparticles 162 6.3.4 Improvement of Scaffold Mechanical Strength 163 References 166 7 Microtubules: Nanobiomechanical Simulation 173 Mohsen Motamedi 7.1 Introduction 173 7.2 Microtubules 174 7.2.1 Assembly and Disassembly of Microtubules 175 7.3 Review on Previous Researches 176 7.3.1 Experimental Researches 176 7.3.2 Analytical and Computational Research 178 7.4 Microtubule Dynamic Instability 179 7.4.1 Nanobiomechanical Model 180 Molecular Dynamic Analysis 180 Molecular Structural Mechanics 181 7.4.2 FinalModel 187 References 187 8 Simulation of Flowing Red Blood Cells with and without Nanoparticle Dispersion Using Particle-based Numerical Methods 191 Abdolrahman Dadvand 8.1 Introduction 191 8.2 Biomechanical Properties of RBCs 192 8.3 RBC Membrane Models 193 8.3.1 Shell-based Membrane Models 193 8.3.2 Spring-based Membrane Models 196 8.3.3 Spring- and Damper-based Membrane Model 197 8.4 Numerical Simulations of RBC Motions in Capillaries 199 8.4.1 Dissipative Particle Dynamics (DPD) Method 199 8.4.2 Smoothed Particle Hydrodynamics (SPH) Method 201 8.4.3 Lattice Boltzmann Method (LBM) 203 8.4.4 Immersed Boundary Method (IBM) 205 8.5 Application of Particle-based Methods to Simulate RBC Motion 205 8.5.1 Preliminary 205 8.5.2 Applications of DPD Method in RBC Simulations 206 Simulation of Single RBC Motion 206 Single RBC Motion in Tube Flow 207 Simulation of Two or Multiple RBC Motion 207 8.5.3 Applications of SPH Method in RBC Simulations 210 8.5.4 Applications of LBM Method in RBC Simulations 211 Simulation of Single RBC Motion 211 Simulation of Two or Multiple RBC Motion 211 Simulation of RBC Suspension Motion 212 8.6 Other Particle-based Methods 212 8.7 Nanoparticle Dispersion in RBC Suspension 213 8.8 Advantages and Disadvantages of Particle-based Methods 215 References 215 9 Impact of Nanofluid in Medical Treatment byMathematical Modeling 227 KhadijaMaqbool and Sidra Shaheen 9.1 Concept of Fluid Mechanics and Basic Laws 227 9.2 Nanofluid and Properties 228 9.3 Newtonian and Non-Newtonian Fluid 229 9.4 Non-Newtonian Fluid FlowModel for Blood 229 9.5 Drug Delivery System 230 9.6 Nanoparticles as Drug Carrier 231 9.7 Importance of Shape and Material Properties of Nanoparticles 231 9.7.1 Carbon-Based Nanoparticles 231 9.7.2 Metallic Nanoparticles 232 9.7.3 Ceramic Nanoparticles 232 9.7.4 Polymeric Nanoparticles 233 9.8 Concentration Properties of Magnetic Nanoparticles 233 9.9 Treatment by Incorporating Magnetic Source 233 9.10 Treatment by Heat Transfer 233 9.11 Boundary Layer Flow of Power Law Nanofluid 234 9.11.1 Solution of the Problem 236 9.11.2 Graphical Results 236 9.12 Casson Nanofluid over a Stretching Surface 237 9.12.1 Solution of the Problem 239 9.12.2 Results and Discussion 239 9.13 Third-grade Nanofluid Flow in a Channel 239 9.13.1 Solution of the Problem 242 9.13.2 Results and Discussion 243 9.14 Hydromagnetic, Irrotational, Laminar Flow of Non-Newtonian Nanofluid Through a Channel 243 9.14.1 Solution of the Problem 248 9.14.2 Results and Discussion 250 References 252 10 Physiological Modeling and Simulation of Fluid Flows 255 Najeeb A. Khan and Faqiha Sultan 10.1 Introduction 255 10.2 Physiological Modeling and Mathematical Formulation 258 10.3 Solution of the Governing Equations 263 10.4 Results and Discussion 264 10.5 Conclusion 273 References 275 Index 279.
  • (source: Nielsen Book Data)9783527344727 20181001
This book comprehensively and systematically treats modern understanding of the Nano-Bio-Technology and its therapeutic applications. The contents range from the nanomedicine, imaging, targeted therapeutic applications, experimental results along with modelling approaches. It will provide the readers with fundamentals on computational and modelling aspects of advanced nano-materials and nano-technology specifically in the field of biomedicine, and also provide the readers with inspirations for new development of diagnostic imaging and targeted therapeutic applications.
(source: Nielsen Book Data)9783527344727 20181001
1 online resource.
  • Preliminaries. Basic Ingredients of the Empirical Likelihood. EL Applying to Bayesian Paradigm. EL for probability weighted moments. Two group comparison and combining likelihoods for the incomplete data. Quantile Comparisons. Empirical Likelihood for a U-Statistic Constraint. EL Application to Receiver Operating Characteristic Curve analysis. Various topics.
  • (source: Nielsen Book Data)9781466555037 20181015
Empirical Likelihood Methods in Biomedicine and Health provides a compendium of nonparametric likelihood statistical techniques in the perspective of health research applications. It includes detailed descriptions of the theoretical underpinnings of recently developed empirical likelihood-based methods. The emphasis throughout is on the application of the methods to the health sciences, with worked examples using real data. The book material is attractive and easily understandable to scientists who are new to the research area and may attract statisticians interested in learning more about advanced nonparametric topics including various modern empirical likelihood methods. The book can be used by graduate students majoring in biostatistics, or in a related field, particularly for those who are interested in nonparametric methods with direct applications in Biomedicine.
(source: Nielsen Book Data)9781466555037 20181015
1 online resource
Nano-inspired Biosensors for Protein Assay with Clinical Applications introduces the latest developments in nano-inspired biosensing, helping readers understand both the fundamentals and frontiers in this rapidly advancing field. In recent decades, there has been increased interest in nano-inspired biosensors for clinical application. Proteins, e.g. antigen-antibody, tumor markers and enzymes are the most important target in disease diagnosis, and a variety of biosensing techniques and strategies have been developed for protein assay. This book brings together all the current literature on the most recent advances of protein analysis and new methodologies in designing new kinds of biosensors for clinical diagnostic use.
1 online resource (xxv, 1428 pages) : illustrations (chiefly color)
  • PART I: Biologic and Molecular Basis for Regenerative Medicine PART II: Cells and Tissue Development PART III: Biomaterials for Regenerative Medicine PART IV: Therapeutic Applications Section A: Cell Therapy Section B: Tissue Therapy PART V: Regulation and Ethics.
  • (source: Nielsen Book Data)9780128098806 20181015
Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies.
(source: Nielsen Book Data)9780128098806 20181015
xiii, 226 pages ; 25 cm.
  • List of Illustrations Preface The Art of Storytelling / Stories of Science: An introduction Daudi Colonial Administration Soliat Primary School Growing up During Independence Hospitalization Student Life and Education Reforms Kericho Tea Hotel On Becoming a Scientist Siberia HLA tissue-typing and kidney transplants in Kenya Science and Technology Amendment Act Daniel arap Moi National Politics The Kenya Medical Research Institute Japan Division of Vector Borne Diseases Wellcome Trust Walter Reed Project / US Army Research Unit The US Embassy and the CDC The KEMRON Trial Saba Saba and the KEMRON Results Kinshasa and Racial Politics A Son's Death Collaborative agreements and fiscal irregularities The Accusations Ethics and Anti-Corruption Commission The Arrest Corporate executive Faith Epilogue by Davy Kiprotich Koech.
  • (source: Nielsen Book Data)9781138059122 20180910
This book examines the development of medical sciences in postcolonial Kenya, through the adventures and stories of the controversial Kalenjin scientist Davy Kiprotich Koech. As a collaborative life story project, it privileges African voices and retellings, re-centring the voice of African scientists from the peripheries of storytelling about science, global health research collaborations, national politics, international geopolitical alliances, and medical research. Focusing largely on the development of the Kenya Medical Research Institute (KEMRI) and its collaborations with the US Centers for Disease Control, the Walter Reed Project, Japan's International Cooperation Agency, the Wellcome Trust, and other international partners, Denielle Elliott and Davy Koech challenge euro-dominant representations of African science and global health in both the contemporary and historical and offer an unconventional account which aims to destabilize colonial and neo-colonial narratives about African science, scientists, and statecraft. The stories force readers to contend with a series of questions including: How do imperial effects shape contemporary medical research and national sovereignty? In which ways do the colonial ghosts of early medical research infuse the struggles of postcolonial scientists to build national scientific projects? How were postcolonial nation-building projects tied up with the dreams and visions of African scientists? And lastly, how might we reimagine African medicine and biosciences? The monograph will be of interest to students, educators, and scholars working in African Studies, Science and Technology Studies, Postcolonial Studies, Global Health, Cultural Anthropology, and Medical Anthropology.
(source: Nielsen Book Data)9781138059122 20180910
Green Library
1 online resource.
3D Bioprinting for Reconstructive Surgery: Techniques and Applications examines the combined use of materials, procedures and tools necessary for creating structural tissue constructs for reconstructive purposes. Offering a broad analysis of the field, the first set of chapters review the range of biomaterials which can be used to create 3D-printed tissue constructs. Part Two looks at the techniques needed to prepare biomaterials and biological materials for 3D printing, while the final set of chapters examines application-specific examples of tissues formed from 3D printed biomaterials. 3D printing of biomaterials for tissue engineering applications is becoming increasingly popular due to its ability to offer unique, patient-specific parts-on demand-at a relatively low cost. This book is a valuable resource for biomaterials scientists, biomedical engineers, practitioners and students wishing to broaden their knowledge in the allied field.
xvi, 229 pages : illustrations (some color) ; 25 cm
  • Overview. Overview of Traditional Medicine Situation in Africa. Legal Framework and Intellectual Property Rights. Property Rights and Traditional Medical Knowledge in Africa: Issues and Development. African Medicinal Plants and Traditional Medical Knowledge: Access and Benefit Sharing in the Context of Research and Development. Validation and Standardization. Using Appropriate Methodology and Technology for Research and Development of African Traditional Medicines. Innovative Nutritional Approach to Attenuate the Progression of HIV to AIDS among People Living with HIV (PLWH): A Study based in Abuja, Nigeria. Research adn Development of Niprisan for the Management of Sickle Cell Disorder. Neem. The Story of Centella asiatica in Madagascar. Development of New Products Based on African Indigenous Medical Knowledge in South Africa. Future Prospects of African Biodiversity and Traditional Medicine. Regulatory Issues Regarding Development and Commercialization of Products Derived from AIMK. African Traditional Medicine: The Way Forward.
  • (source: Nielsen Book Data)9781138038103 20180611
Despite the relevance of and empirical evidence for African Traditional Medicine, based on African Indigenous Medical Knowledge (AIMK), research and development of new phytomedicines from this continent has been slow. African Indigenous Medical Knowledge and Human Health aims to provide a catalyst for health innovations based on the rich African biodiversity and AIMK. The book documents some of the success stories from the continent related to AIMK and serves as a one-step reference for all professionals interested in the research and development of medical interventions - including pharmacognosists, ethnobiologists, botanists, phytochemists, pharmacologists and medical scientists.
(source: Nielsen Book Data)9781138038103 20180611
Green Library
xxiv, 372 pages ; 23 cm
'Written with perceptive sympathy for the wounded healer, it is necessary reading for both doctors and patients.' Hilary Mantel 'Crucial and timely.' Atul Gawande 'A furious dispatch from the front line of the hospital system.' The Times, 'Book of the Week' 'Fascinating and troubling. Read it and weep.' Susie Orbach 'Haunting, beautiful and urgent.' Johann Hari 'At the heart of this book is the problem of how emotional resilience can be identified in prospective doctors and strengthened in practising doctors. We are fallible human beings, not omniscient gods.' Henry Marsh, Sunday Times Doctors are the people we turn to when we fall ill. They are the people we trust with our lives, and with the lives of those we love. Yet who can doctors turn to at moments of stress, or when their own working lives break down? What does it take to confront death, disease, distress and suffering every day? To work in a healthcare system that is stretched to breaking point? To carry the responsibility of making decisions that can irrevocably change someone's life - or possibly end it? And how do doctors cope with their own questions and fears, when they are expected to have all the answers? Caroline Elton is a psychologist who specialises in helping doctors. For over twenty years she has listened as doctors have unburdened themselves of the pressures of their jobs: the obstetrician whose own fertility treatment failed; the trainee oncologist who found herself unable to treat patients suffering from the disease that killed her father; the brilliant neurosurgeon struggling to progress her career in an environment that was hostile to women. Drawing on extraordinary case studies and decades of work supporting clinicians, Also Human presents a provocative, perceptive and deeply humane examination of the modern medical profession.
(source: Nielsen Book Data)9781785150906 20180521
Green Library
341 pages : illustrations ; 24 cm.
  • Thematische Einführung
  • Mathias Schmidt, Jens Westemeier und Dominik Gross : die Ärzte der Nazi-Führer : Karrieren und Netzwerke
  • Dominik Gross und Mathias Schmidt
  • Leibärzte : Begriffsdefinition : Kennzeichen : Entwicklungslinien : ein Problemaufriss
  • Hitlers Behandler und ihre Netzwerke
  • Henrik Eberle : Morell und Hitler : Hitler und Morell
  • Thomas Beddies : Eminent politisch : die I. Chirurgische Klinik der Berliner Universität im "Dritten Reich"
  • Stephanie Kaiser : Ludwig Stumpfegger : eine Karriere im Nationalsozialismus
  • Menevse Deprem-Hennen und Jens Westemeier : SS-Brigadeführer Hugo Johannes Blaschke : Hitlers "Leibzahnarzt"
  • Die Behandler der NS-Führungsriege und ihre Karrieren
  • Eva-Maria Ulmer : Karl Fahrenkamp : eine erste Annäherung
  • Florian G. Mildenberger : der Heilpraktiker des Reichsführers-SS : Karl Hann von Weyherns Karrieren
  • Julia Nebe und Jan Kleinmanns : Wenn der Paladin krank wurde : Hermann Görings Leibarzt : Ramon von Ondarza
  • Andreas Thum : "Mein ganzes Glück als Frau und Mutter verdanke ich zu einem grossen Teil : Ihnen" : die Beziehung Walter Stoeckels zu Magda und Joseph Goebbels
  • Die Ärzte der NS-Eliten und ihre Bioergografien
  • Niels Weise : KZ-Karrieren : Werner Heyde und Theodor Eicke
  • Gisela Tascher : Wilhelm Ewig : Erster "Gaugesundheitsführer" und Leibarzt der Familie von Gauleiter Joseph Bürckel
  • Philipp Rauh : Hermann Wintz : der Arzt, dem die fränkischen Gauleiter vertrauten
  • Mathias Schmidt, Tina Winzen und Dominik Gross : Professor Hans Holfelder, Gauleiter Jakob Sprenger und die Röntgenologie in Frankfurt am Main
  • Rezeption und Exkulpation
  • Jens Westemeier : Ernst Günther Schenck : vom SS-Arzt zum "Gehilfen der Historiker"
  • Jan Armbruster und Peter Theiss-Abendroth : zur Diskussion um Adolf Hitlers psychischen Gesundheitszustand
  • Korrespondenzadressen.
SAL3 (off-campus storage)
1 online resource.
  • Preface vii 1 Introduction 1 References 3 2 Nanomaterials 5 2.1 Physical Properties of Nanomaterials 5 2.1.1 Thermodynamic Properties: Melting Point Depression and Superheating 7 2.1.2 Optical Properties 10 2.1.3 Magnetism 14 2.2 Nanomaterials: An Overview 21 2.2.1 Organic Nanoparticles 21 2.2.2 Inorganic Nanoparticles 38 References 65 3 Promising Applications in Medicine 79 3.1 Diagnostics 80 3.1.1 X-Ray Computed Tomography 80 3.1.2 Photoacoustic Imaging 85 3.1.3 Positron Emission Tomography 88 3.1.4 Magnetic Resonance Imaging 90 3.1.5 Raman-Based Diagnostics 95 3.2 Therapy 99 3.2.1 Chemotherapy 99 3.2.2 Hyperthermia 105 3.2.3 Radiotherapy 112 References 116 4 Interactions of Nanomaterials with Biological Systems 137 4.1 Cellular Level (in vitro) 137 4.1.1 Cellular Uptake and Intracellular Fate 137 4.1.2 Physio-Chemical Dependence of Nanomaterials Uptake 145 4.1.3 Cytotoxicity 149 4.2 Body Level (in vivo) 153 4.2.1 Blood Circulation 154 4.2.2 Immune/Inflammatory Response 168 4.2.3 Metabolism (RES, Degradation, Excretion and Persistence) 173 References 183 5 Nanomaterials in the Market or in the Way of 201 5.1 Approval pipeline (FDA and EMA) 202 5.2 Nanotherapeutics 205 5.3 Nanodiagnostics 209 References 212 6 Avoiding the Persistence of Metal Nanomaterials 217 6.1 Ultrasmall-in-Nano Approach 218 6.2 Porphyrin-Based Nanomaterials 229 References 233 7 Conclusions and Perspectives 241 References 244 Index 247.
  • (source: Nielsen Book Data)9781119418955 20180702
In the last two decades, several promising engineered nanomaterials that combine therapeutic features and imaging functionalities have been presented, but very few have arrived on the market. The purpose of this book is to collect and comprehensively discuss the advances in this current and exciting topic in order to promote and enhance its growth. In the first part, a general introduction about the main features of both organic and inorganic nanomaterials is provided. Then, the most promising and innovative applications for cancer treatment and diagnostic are introduced. In the second part, an analysis of the nanomaterials in the market for healthcare applications is presented. The issue of unwanted accumulation of metals in organisms after the designed action is then discussed. Finally, the most recent progresses in the design of nanomaterials that are able to escape from organisms after the selected action are comprehensively described, and the perspectives of this exciting field provided.
(source: Nielsen Book Data)9781119418955 20180702
1 online resource.
1 online resource.
  • Preface 1 Overview 2 Structure, microstructure, and properties of bioceramics 3 Osteoinduction, osteoconduction, and osseointegration 4 Orthopedic and dental applications 5 Hard tissue engineering applications 6 Recent research trends Index.
  • (source: Nielsen Book Data)9780081022337 20181015
Bioceramics: For Materials Science and Engineering provides a great working knowledge on the field of biomaterials, including the interaction of biomaterials with their biological surroundings. The book discussees the biomedical applications of materials, the standpoint of biomedical professionals, and a real-world assessment of the academic research in the field. It addresses the types of bioceramics currently available, their structure and fundamental properties, and their most important applications. Users will find this to be the only book to cover all these aspects.
(source: Nielsen Book Data)9780081022337 20181015
1 online resource (xiv, 212 pages) : illustrations (some color).
  • Dedication...Preface...Table of Contents...Contributing Authors... 1. Engineering Citric-Acid Based Porous Scaffolds for Bone RegenerationJacqueline J. Masehi-Lano and Eun Ji Chung 2. Multifunctional Self-Assembling Peptide-Based Micelles for Targeted Intracellular Delivery: Design, Physicochemical Characterization, and Biological AssessmentYejiao Shi, Ran Lin, Honggang Cui, and Helena S. Azevedo 3. Electrospinning Functionalized Polymers for Use as Tissue Engineering ScaffoldsLesley W. Chow 4. Low-Temperature Deposition Modelling for CP Scaffolds with Controlled Bimodal PorosityE. Papastavrou, P. Breedon, and D. Fairhurst 5. Three-Dimensional Hydrogel-Based Culture to Study the Effects of Toxicants on Ovarian FolliclesHong Zhou and Ariella Shikanov 6. Layer-by-Layer Engineered Polymer Capsules for Therapeutic DeliveryRona Chandrawati 7. Controlling Fibrin Network Morphology, Polymerization, and Degradation Dynamics in Fibrin Gels for Promoting Tissue RepairErin P. Sproul, Riley T. Hannan, and Ashley C. Brown 8. Biofunctionalization of Poly(acrylamide) GelsJulieta I. Paez, Aleeza Farrukh, Oya Ustahuseyin, and Aranzazu del Campo 9. Synthetic PEG Hydrogel for Engineering the Environment of Ovarian FolliclesUziel Mendez, Hong Zhou, and Ariella Shikanov 10. Engineering Human Neural Tissue by 3D BioprintingQi Gu, Gordon G. Wallace, and Jeremy M. Crook 11. High-Throughput Formation of Mesenchymal Stem Cell Spheroids and Entrapment in Aliginate HydrogelsCharlotte E. Vorwald, Steve S. Ho, Jacklyn Whitehead, and J. Kent Leach 12. Crimped Electrospun Fibers for Tissue EngineeringPen-hsiu Grace Chao 13. In Vitro Model of Macrophage-Biomaterial InteractionsClaire E. Witherel, Pamela L. Graney, and Kara L. Spiller 14. Synthesis of Self-Assembling Peptide-Based Hydrogels for Regenerative Medicine Using Solid-Phase Peptide SynthesisE. Thomas Pashuck 15. H2S Delivery from Aromatic Peptide Amphiphile HydrogelsKuljeet Kaur, Yun Qian, and John B. Matson.
  • (source: Nielsen Book Data)9781493977390 20180717
This volume provides protocols for the generation of various biomaterials for tissue engineering and regenerative medicine applications. The chapters in this book include a look at a range of biomaterials including hydrogels and other matrices (natural, synthetic, self-healing) for various applications including drug and gene delivery, surface modification and functionalization of biomaterials. In addition, techniques described include those for controlling biomaterial geometry, such as three-dimensional printing and electrospinning. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Biomaterials for Tissue Engineering: Methods and Protocols is a valuable resource for scientists and engineers interested in this vital field of study.
(source: Nielsen Book Data)9781493977390 20180717
1 online resource.
  • Front Cover; Biomedical Applications of Functionalized Nanomaterials; Biomedical Applications of Functionalized Nanomaterials; Copyright; Contents; List of Contributors; Preface; REFERENCES; 1
  • From the â#x80; #x9C; Magic Bulletâ#x80; #x9D; to Advanced Nanomaterials for Active Targeting in Diagnostics and Therapeutics; 1. PAUL EHRLICH AND THE â#x80; #x9C; MAGIC BULLETâ#x80; #x9D; ; 2. PASSIVE VERSUS ACTIVE TARGETING IN CANCER AS MODEL; 2.1 SUGARS; 2.2 TRANSFERRIN AND LACTOFERRIN; 2.3 FOLIC ACID; 2.4 HYALURONIC ACID; 2.5 ANTIBODIES; 2.6 APTAMERS; 3. EMERGING CHALLENGES AND PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES
  • I
  • Ligand Selection and Functionalization of Nanomaterials2
  • Conjugation Chemistry Principles and Surface Functionalization of Nanomaterials; 1. CONJUGATION CHEMISTRY IN THE CONTEXT OF BIOMEDICAL NANOMATERIALS; 2. CONJUGATION CHEMISTRY PRINCIPLES; 2.1 AMINE REACTIONS; 2.1.1 Amide Bond Formation: Strategies; Acyl Halides; Acyl Azides; Acylimidazoles; Anhydrides; O-Acylisourea Using Carbodiimides as Coupling Reagents; Active Esters; Staudinger Ligation; Microwave Activation; 2.1.2 Phosphoramidate Formation: Strategies
  • 2.2 THIOL REACTIONS2.2.1 Thioether Bond Formation: Addition of Thiols at Multiple Bonds of Unsaturated Compounds; 2.2.2 Disulfide Bridge; 2.3 HYDROXYL REACTIONS; 2.3.1 Ester Bond Formation: Strategies; Acyl Halides, Anhydrides, and O-Acylisoureas via Carbodiimide Coupling; Mitsunobu Coupling; 2.3.2 Carbamate Linkage Formation: Strategies; 2.4 CARBOXYLIC ACID REACTIONS; 2.5 ALDEHYDES AND KETONES REACTIONS; 2.6 ALKENES AND ALKYNES; 2.6.1 Dielsâ#x80; #x93; Alder Cycloaddition; 2.6.2 Click Chemistry; Huisgen 1,3-Dipolar Azideâ#x80; #x93; Alkyne Cycloadditions; 2.7 PHOTOCHEMICAL REACTIONS
  • 3. SELF-ASSEMBLED MONOLAYERS AS A POWERFUL TOOL FOR THE DESIGN OFâ#x80; S̄URFACE-ENGINEERED NANOMATERIALS3.1 BIOMOLECULES CONJUGATION ONTO SELF-ASSEMBLED MONOLAYERS VIA COVALENT BINDING; 3.1.1 Maleimide-Terminated Self-Assembled Monolayers; 3.1.2 Alkyne or Azide-Terminated Self-Assembled Monolayersâ#x80; (̄â#x80; #x9C; Click Chemistryâ#x80; #x9D; ); 3.1.3 Carboxylic Acid-Terminated Self-Assembled Monolayers; 3.1.4 Hydroxyl-Terminated Self-Assembled Monolayers; 3.2 BIOMOLECULES CONJUGATION ON SELF-ASSEMBLED MONOLAYERS VIAâ#x80; ĀFFINITY BINDING; 4. CHALLENGES IN (BIO)CONJUGATION; REFERENCES
  • 3
  • Ribosome Display Technology for Selecting Peptide and Protein Ligands; 1. INTRODUCTION
Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies.
1 online resource.
This lecture volume aims to give students and researchers in this rapidly expanding field of biophotonics an interdisciplinary perspective. Among the primary topics are ultrahigh resolution microscopy, particle tracking, photon correlation spectroscopy, and nonlinear optical methods as used in biological and biomedical research, with a focus on current applications in biophysics and biomedicine.
(source: Nielsen Book Data)9789813235687 20181015
1 online resource.
  • List of Contributors xi Preface xv Acknowledgments xvii Section 1 Introduction to Biosensors, Recognition Elements, Biomarkers, and Nanomaterials 1 1 General Introduction to Biosensors and Recognition Receptors 3Frank Davis and Zeynep Altintas 1.1 Introduction to Biosensors 3 1.2 Enzyme- Based Biosensors 4 1.3 DNA- and RNA-Based Biosensors 5 1.4 Antibody-Based Biosensors 7 1.5 Aptasensors 8 1.6 Peptide-Based Biosensors 10 1.7 MIP-Based Biosensor 11 1.8 Conclusions 12 References 13 2 Biomarkers in Health Care 17Adama Marie Sesay, Pirkko Tervo, and Elisa Tikkanen 2.1 Introduction 17 2.2 Biomarkers 18 2.2.1 Advantage and Utilization of Biomarkers 18 2.2.2 Ideal Characteristics of Biomarkers 19 2.3 Biological Samples and Biomarkers 20 2.4 Personalized Health and Point-of-Care Technology 22 2.5 Use of Biomarkers in Biosensing Technology 24 2.6 Biomarkers in Disease Diagnosis 26 2.7 Conclusions 29 References 30 3 The Use of Nanomaterials and Microfluidics in Medical Diagnostics 35Jon Ashley and Yi Sun 3.1 Introduction 35 3.2 Nanomaterials in Medical Diagnostics (Bottom-Up Approach) 36 3.2.1 Carbon Nanomaterials 37 3.2.2 Metallic Nanoparticles 39 Quantum Dots 39 Magnetic Nanoparticles (Fe2O3, FeO, and Fe3O4) 41 Gold Nanoparticles 41 Silver Nanoparticles 42 Nanoshells 42 Nanocages 43 Nanowires 43 3.2.3 Polymer-Based Nanoparticles 44 3.3 Application of Microfluidic Devices in Clinical Diagnostics (Top-Down Approach) 45 3.3.1 Unique Features of Microfluidic Devices 45 3.3.2 Applications of Microfluidic Devices in Medical Diagnostics 46 Types of Microfluidic POC Devices 47 Benchtop Microfluidic Instruments 47 Small, Lightweight Microfluidic Devices 49 Simple Un-instrumented Microfluidic Systems 50 3.4 Integration of Microfluidics with Nanomaterials 52 3.5 Future Perspectives of Nanomaterial and Microfluidic-Based Diagnostics 53 References 54 Section 2 Biosensor Platforms for Disease Detection and Diagnostics 59 4 SPR-Based Biosensor Technologies in Disease Detection and Diagnostics 61Zeynep Altintas and Wellington M. Fakanya 4.1 Introduction 61 4.2 Basic Theoretical Principles 63 4.3 SPR Applications in Disease Detection and Diagnostics 66 4.3.1 SPR Biosensors in Cancer Detection 66 4.3.2 SPR Sensors in Cardiac Disease Detection 68 4.3.3 SPR Sensors in Infectious Disease Detection 71 4.4 Conclusions 72 References 74 5 Piezoelectric-Based Biosensor Technologies in Disease Detection and Diagnostics 77Zeynep Altintas and Noor Azlina Masdor 5.1 Introduction 77 5.2 QCM Biosensors 78 5.3 Disease Diagnosis Using QCM Biosensors 80 5.3.1 Cancer Detection Using QCM Biosensors 82 5.3.2 Cardiovascular System Disorder Detection Using Biosensors 85 5.3.3 Pathogenic Disease Detection Using QCM Biosensors 88 5.4 Conclusions 90 References 91 6 Electrochemical-Based Biosensor Technologies in Disease Detection and Diagnostics 95Andrea Ravalli and Giovanna Marrazza 6.1 Introduction 95 6.2 Electrochemical Biosensors: Definitions, Principles, and Classifications 96 6.3 Biomarkers in Clinical Applications 102 6.3.1 Electrochemical Biosensors for Tumor Markers 102 6.3.2 Electrochemical Biosensors for Cardiac Markers 110 6.3.3 Electrochemical Biosensors for Autoimmune Disease 115 6.3.4 Electrochemical Biosensors for Autoimmune Infectious Disease 116 6.4 Conclusions 118 References 118 7 MEMS-Based Cell Counting Methods 125Mustafa Kangul, Eren Aydin, Furkan Gokce, Ozge Zorlu, Ebru Ozgur, and Haluk Kulah 7.1 Introduction 125 7.2 MEMS-Based Cell Counting Methods 126 7.2.1 Optical Cell Counting Methods 126 Quantification of the Cells by Detecting Luminescence 127 Quantification of the Cells via High-Resolution Imaging Techniques 130 7.3 Electrical and Electrochemical Cell Counting Methods 131 7.3.1 Impedimetric Cell Quantification 133 7.3.2 Voltammetric and Amperometric Cell Quantification 135 7.4 Gravimetric Cell Counting Methods 136 7.4.1 Deflection-Based Cell Quantification 136 7.4.2 Resonant-Based Cell Quantification 138 Theory of the Resonant-Based Sensors 138 Actuation and Sensing Methods of Resonators in MEMS Applications 140 Resonator Structure Types Used for Cell Detection Applications 145 7.5 Conclusion and Comments 149 References 151 8 Lab-on-a-Chip Platforms for Disease Detection and Diagnosis 155Ziya Isiksacan, Mustafa Tahsin Guler, Ali Kalantarifard, Mohammad Asghari, and Caglar Elbuken 8.1 Introduction 155 8.2 Continuous Flow Platforms 156 8.3 Paper-Based LOC Platforms 161 8.4 Droplet-Based LOC Platforms 166 8.5 Digital Microfluidic-Based LOC Platforms 169 8.6 CD-Based LOC Platforms 172 8.7 Wearable LOC Platforms 174 8.8 Conclusion and Outlook 176 References 177 Section 3 Nanomaterial's Applications in Biosensors and Diagnostics 183 9 Applications of Quantum Dots in Biosensors and Diagnostics 185Zeynep Altintas, Frank Davis, and Frieder W. Scheller 9.1 Introduction 185 9.2 Quantum Dots: Optical Properties, Synthesis, and Surface Chemistry 186 9.3 Biosensor Applications of QDs 187 9.4 Other Biological Applications of QDs 191 9.5 Water Solubility and Cytotoxicity 194 9.6 Conclusion 196 References 197 10 Applications of Molecularly Imprinted Nanostructures in Biosensors and Diagnostics 201Deniz Aktas-Uygun, Murat Uygun, and Sinan Akgol 10.1 Introduction 201 10.2 Molecular Imprinted Polymers 202 10.3 Imprinting Approaches 204 10.4 Molecularly Imprinted Nanostructures 205 10.5 MIP Biosensors in Medical Diagnosis 207 10.6 Diagnostic Applications of MIP Nanostructures 210 10.7 Conclusions 212 References 213 11 Smart Nanomaterials: Applications in Biosensors and Diagnostics 219Frank Davis, Flavio M. Shimizu, and Zeynep Altintas 11.1 Introduction 219 11.2 Metal Nanoparticles 221 11.3 Magnetic Nanoparticles 226 11.4 Carbon Nanotubes 231 11.5 Graphene 235 11.6 Nanostructured Metal Oxides 242 11.7 Nanostructured Hydrogels 247 11.8 Nanostructured Conducting Polymers 254 11.9 Conclusions and Future Trends 260 References 262 12 Applications of Magnetic Nanomaterials in Biosensors and Diagnostics 277Zeynep Altintas 12.1 Introduction 277 12.2 MNP-Based Biosensors for Disease Detection 279 12.3 MNPs in Cancer Diagnosis and Therapy 284 12.4 Cellular Applications of MNPs in Biosensing, Imaging, and Therapy 289 12.5 Conclusions 290 References 291 13 Graphene Applications in Biosensors and Diagnostics 297Adina Arvinte and Adama Marie Sesay 13.1 Introduction 297 13.2 Graphene and Biosensors 298 13.2.1 Structure 298 13.2.2 Preparation 299 13.2.3 Properties 301 13.2.4 Commercialization in the Field of Graphene Sensors 302 13.2.5 Latest Developments in Graphene-based Diagnosis 303 13.3 Medical Applications of Graphene 303 13.3.1 Electrochemical Graphene Biosensors for Medical Diagnostics 304 Glucose Detection 304 Cysteine Detection 307 Cholesterol Detection 309 Hydrogen Peroxide (H2O2) 310 Glycated Hemoglobin 312 Neurotransmitters 312 Amyloid-Beta Peptide 315 13.3.2 Electrochemical Graphene Aptasensors 316 Nucleic Acids 316 Cancer Cell 318 13.3.3 Optical Graphene Sensors for Medical Diagnostics 319 13.4 Conclusions 322 Acknowledgments 322 References 322 Section 4 Organ-Specific Health Care Applications for Disease Cases Using Biosensors 327 14 Optical Biosensors and Applications to Drug Discovery for Cancer Cases 329Zeynep Altintas 14.1 Introduction 329 14.2 Biosensor Technology and Coupling Chemistries 332 14.3 Optical Biosensors for Drug Discovery 335 14.4 Computational Simulations and New Approaches for Drug-Receptor Interactions 341 14.5 Conclusions 343 References 344 15 Biosensors for Detection of Anticancer Drug-DNA Interactions 349Arzum Erdem, Ece Eksin, and Ece Kesici 15.1 Introduction 349 15.2 Electrochemical Techniques 351 15.3 Optical Techniques 356 15.4 Electrochemical Impedance Spectroscopy Technique 358 15.5 QCM Technique 360 15.6 Conclusions 361 Acknowledgments 361 References 361 Index.
  • (source: Nielsen Book Data)9781119065012 20171204
Provides a broad range of information from basic principles to advanced applications of biosensors and nanomaterials in health care diagnostics This book utilizes a multidisciplinary approach to provide a wide range of information on biosensors and the impact of nanotechnology on the development of biosensors for health care. It offers a solid background on biosensors, recognition receptors, biomarkers, and disease diagnostics. An overview of biosensor-based health care applications is addressed. Nanomaterial applications in biosensors and diagnostics are included, covering the application of nanoparticles, magnetic nanomaterials, quantum dots, carbon nanotubes, graphene, and molecularly imprinted nanostructures. The topic of organ-specific health care systems utilizing biosensors is also incorporated to provide deep insight into the very recent advances in disease diagnostics. Biosensors and Nanotechnology: Applications in Health Care Diagnostics is comprised of 15 chapters that are presented in four sections and written by 33 researchers who are actively working in Germany, the United Kingdom, Italy, Turkey, Denmark, Finland, Romania, Malaysia and Brazil. It covers biomarkers in healthcare; microfluidics in medical diagnostics; SPR-based biosensor techniques; piezoelectric-based biosensor technologies; MEMS-based cell counting methods; lab-on-chip platforms; optical applications for cancer cases; and more. Discusses the latest technology and advances in the field of biosensors and their applications for healthcare diagnosticsParticular focus on biosensors for cancerSummarizes research of the last 30 years, relating it to state-of-the-art technologies Biosensors and Nanotechnology: Applications in Health Care Diagnostics is an excellent book for researchers, scientists, regulators, consultants, and engineers in the field, as well as for graduate students studying the subject.
(source: Nielsen Book Data)9781119065012 20171204