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1 volume (various pagings) : color illustrations ; 29 cm
  • Part One Organization of the Body 1 Major Themes of Anatomy and PhysiologyATLAS A General Orientation to Human Anatomy 2 The Chemistry of Life 3 Cellular Form and Function 4 Genetics of Cellular Function 5 Histology Part Two Support and Movement 6 The Integumentary System 7 Bone Tissue 8 The Skeletal System 9 Joints 10 The Muscular SystemATLAS B Regional and Surface Anatomy 11 Muscular Tissue Part Three Internal Coordination and Control 12 Nervous Tissue 13 The Spinal Cord, Spinal Nerves, and Somatic Reflexes 14 The Brain and Cranial Nerves 15 The Autonomic Nervous System and Visceral Reflexes 16 Sense Organs 17 The Endocrine System Part Four Circulation and Defense 18 The Circulatory System: Blood 19 The Circulatory System: Heart 20 The Circulatory System: Blood Vessels and Circulation 21 The Lymphatic and Immune Systems Part Five Intake and Output 22 The Respiratory System 23 The Urinary System 24 Fluid, Electrolyte, and Acid - Base Balance 25 The Digestive System 26 Nutrition and Metabolism Part Six Reproduction and the Life Cycle 27 The Male Reproductive System 28 The Female Reproductive System 29 Human Development and Aging APPENDIX A: Periodic Table of the Elements APPENDIX B: Answer Keys APPENDIX C: Symbols, Weights, and Measures APPENDIX D: Biomedical Abbreviations APPENDIX E: The Genetic Code APPENDIX F: Lexicon of biomedical Word Elements APPENDIX G: Eighth Edition Changes in Terminology Glossary CreditsIndex.
  • (source: Nielsen Book Data)9781259277726 20170410
Master the story of Anatomy & Physiology with Saladin's Anatomy & Physiology: The Unity of Form and Function! Saladin's A&P helps students make connections by telling a story that will intrigue, engage, and inspire them. Saladin expertly weaves together science, clinical applications, history and evolution of the body with vibrant photos and art to convey the beauty and excitement of the subject. A consistent set of chapter learning tools helps students identify and retain key concepts while the stunning visual program provides a realistic view of body structures and processes. Saladin's text requires no prior knowledge of college chemistry or cell biology, and is designed for a two-semester A&P course.
(source: Nielsen Book Data)9781259277726 20170410
Science Library (Li and Ma)
1 online resource (xiii, 260 pages) : illustrations (some color).
  • Cloning and identification of recombinant argonaute-bound small RNAs using next-generation sequencing / Pooja Gangras, Daniel M. Dayeh, Justin W. Mabin, Kotaro Nakanishi, and Guramrit Singh
  • Quantification of miRNAs co-immunoprecipitated with argonaute proteins using SYBR green-based qRT-PCR / Hong-Duc Phan, Junan Li, Ming Poi, and Kotaro Nakanishi
  • Gateway to understanding argonaute loading of single-stranded RNAs : preparation of deep sequencing libraries with in vitro loading samples / Eling Goh and Katsutomo Okamura
  • Dumbbell-PCR for discriminative quantification of a small RNA variant / Megumi Shigematsu, Shozo Honda, and Yohei Kirino
  • MicroRNA detection by whole-mount in situ hybridization in C. elegans / Yoshiki Andachi and Yuji Kohara
  • cCLIP-seq : retrieval of chimeric reads from HITS-CLIP (CLIP-Seq) libraries / Panagiotis Alexiou, Manolis Maragkakis, Zissimos Mourelatos, and Anastassios Vourekas-- Kinetic analysis of small silencing RNA production by human and drosophila dicer enzymes in vitro / Susan E. Liao and Ryuya Fukunaga
  • Nucleic acid-binding assay of argonaute protein using fluorescence polarization / Tomohiro Miyoshi
  • Reconstitution of RNA interference machinery / Shintaro Iwasaki and Yukihide Tomari
  • Single-molecule analysis for RISC assembly and target cleavage / Hiroshi M. Sasaki, Hisashi Tadakuma, and Yukihide Tomari
  • Profiling open chromatin structure in the ovarian somatic cells using ATAC-seq / Kensaku Murano, Yuka W. Iwasaki, and Haruhiko Siomi
  • Assessing miR-451 activity and its role in erythropoiesis / Dmitry A. Kretov, Andrew M. Shafik, and Daniel Cifuentes
  • Functional analysis of microRNAs in neurogenesis during mouse cortical development / Wei Zhang, Xiaoxia Zeng, and Li Zeng
  • Cellular approaches in investigating argonaute2-dependent RNA silencing / Cai Zhang, Joonbae Seo, and Takahisa Nakamura
  • Genomic tagging of AGO1 using CRISPR/Cas9-mediated homologous recombination / Sanjay Ghosh and Ji-Long Liu
  • Accurate profiling and quantification of tRNA fragments from RNA-Seq data : a Vade Mecum for MINTmap / Phillipe Loher, Aristeidis G. Telonis, and Isidore Rigoutsos.
1 online resource (xii, 355 pages) : illustrations (some color).
1 online resource. Digital: text file; PDF.
  • 1. Strontium in ecosystem: Transfer in plants via root system. S.Chatterjee, C. Walther, D.K.Gupta, Gottfried Wilhelm Leibniz Universitat Hannover Institut fur Radiookologie und Strahlenschutz (IRS)Herrenhauser Strasse 2,30419 Hannover, Germany2. Bioavailability of strontium in soils: Influence of radionuclide speciation on the soil-plant transfer. J. Guillen, A. Salas, J.A. Corbacho, A. Baeza LARUEX (Environmental Radioactivity Laboratory)Dpt. Applied Physics, Faculty of Veterinary Sciences, University of Extremadura, Avda. Universidad, s/n, 10003, Caceres, Spain3. Distribution of strontium in soil: Interception, weathering, speciation and translocation to plants.S. Dubchak, State Ecological Academy of Postgraduate Education and Management 03035, V. Lypkivsky str. 35, building 2, Kiev, Ukraine 4. Accumulation of the 90Sr by plants of different taxonomic groups from the soils at the Eastern Ural Radioactive Trace.L.N. Mikhailovskaya, V.N. Pozolotina, E.V. Antonova, Laboratory of Population Radiobiology, Institute of Plant & Animal Ecology, Ural Branch of the Russian Academy of Sciences, 202 8 Marta St., 620144 Ekaterinburg, Russia5. Exposure of plants due to 90Sr contamination in the area of Eastern Ural Radioactive Trace.L.N. Mikhailovskaya, I.V. Yarmoshenko, G.P. Malinovsky, V.N. Pozolotina, E.V. Antonova, Ecology, Ural Branch, Russian Academy of Sciences, Sophy Kovalevskoy 20, 620219 Ekaterinburg, Russia6. Laws of behaviour of strontium-90 in the terrestrial and aquatic ecosystems of the Southern Urals.N.N. Kazachonok, I.Y. Popova, Belarus-Russian University, st. Mira, 43, Mogilev-212030, Belarus 7. Migration of the 90Sr in the ecosystems of the Chernobyl Exclusive Zone (Belarussian Part).S. Kalinichenko, A. Nikitin, O. Shurankova, I. Cheshyk Institute of the Radiobiology of the National Academy of Sciences of Belarus, Gomel, Belarus, 8. Contamination of the forest wood of exclusion zone of Chernobyl NPP by 90Sr according to data of 2005-2015.V. Zabrotski, Polessje State Radiation-Ecological Reservation, Tereshkova str. 7, Khoiniki, Gomel region, 247618, Belarus9. Peculiarities of 90Sr distribution in soil system - Scots pine (Pinus sylvestris L.).Dr. I.P. Bataitiene, Utena University of Applied Sciences, Faculty of Business and Technologies, Department of Environment Protection Engineering, Maironio 17 str., LT-28142, Utena, Lithuania10. 87Sr/86Sr in Vitis vinifera and its relationships with the geological substratum of the vineyard.Dr. S. Conticelli, Dipartimento di Scienze della Terra, Universita degli Studi di Firenze, Via Giorgio La Pira, 4, I-50121, Firenze, Italy11. Hereditary component of variation in 90Sr kinetics.Dr. V.I. Starichenko, Institute of Plants and Animal Ecology, Ural Branch, Russian Academy of Sciences, Vos'mogo Marta St. 202, 620144, Ekaterinburg, Russia12. Soil-to-crop transfer factors of alkaline earth elements and comparison with global fallout 90Sr.Dr. K. Tagami, Biospheric Assessment for Waste Disposal Team, National Institute of Radiological Sciences, Anagawa 4-9-1, Inage-ku, Chiba 263-8555, Japan Appendice.
  • (source: Nielsen Book Data)9783319665733 20180115
This book provides extensive and comprehensive knowledge to researchers and academics who work on strontium contaminated areas. Topics covered include impact on plants and environment, as well as remediation strategies. This book will inform graduate and undergraduate students who are specializing in radioecology, especially strontium uptake via soil to plants, safe disposal of strontium waste, remediation legacies and impact of strontium waste material on the natural and manmade environment. A broad overview of reviews is provided covering a number of original publications on strontium plant uptake, including case studies that present the latest technological developments and future trends for investigating strontium mobility in soil and treatment of strontium contaminated areas.
(source: Nielsen Book Data)9783319665733 20180115
1 online resource : illustrations.
  • 1. Introduction 2. Methodologies for studying bioactive polysaccharides 3. Beta-Glucans from Fungi 4. Curdlan and derivatives 5. Dendronan from Dendrobium officinale and Aloe 6. Complex Glucomannan from Ganoderma atrum 7. Cordyceps Polysaccharides 8. Tea Polysaccharides 9. Psyllium Polysaccharides 10. Other Herbal Polysaccharides.
  • (source: Nielsen Book Data)9780128094181 20171204
Bioactive Polysaccharides offers a comprehensive review of the structures and bioactivities of bioactive polysaccharides isolated from traditional herbs, fungi, and seaweeds. It describes and discusses specific topics based on the authors' rich experience, including extraction technologies, practical techniques required for purification and fractionation, strategies and skills for elucidating the fine structures, in-vitro and in-vivo protocols, and methodologies for evaluating the specific bioactivities, including immune-modulating activities, anti-cancer activities, anti-oxidant activities, and others. This unique book also discusses partial structure-functionality (bioactivities) relationships based on conformational studies. This comprehensive work can be used as a handbook to explore potential applications in foods, pharmaceuticals, and nutraceutical areas for commercial interests.
(source: Nielsen Book Data)9780128094181 20171204
1 online resource.
  • Probabilities and Statistics in Chemical and Biothermodynamics Elementary Events. How Probabilities Combine. Permutation versus composition. Discrete Probability Distributions Continuous Distributions Mathematical Tools in Thermodynamics Calculus in Thermodynamics. Fitting continuous curves to discrete data. Determining the covariance matrix in least-squares fitting. Model testing with the 2 and f-ratio probability distributions. The Framework of Thermodynamics and the First Law What is Thermodynamics and What Does it Treat? Dividing up the Universe: System and Surroundings Equilibrium, Changes of State, and Reversibility Thermodynamic Variables and Equations of State The First law of Thermodynamics Work The reversible work associated with four fundamental changes of state. The heat flow associated with the four fundamental changes in an ideal gas. The work associated with the irreversible expansion of an ideal gas. The connection between heat capacities and state functions. A non-ideal model: the van der Walls equation of state The Second Law and Entropy Some familiar examples of spontaneous change. Spontaneous change and statistics The directionality of heat flow at the macroscopic (classical) level Free Energy as a Potential for the Laboratory and Biology Internal energy as a potential--combining the first and second laws. Contributions of different chemical species to thermodynamic state functions-molar quantities. Partial pressures of mixtures of gases. Legendre transforms of a single variable. Using Chemical Potentials to Describe Phase Transitions Phases and their transformations. The condition for equilibrium between two phases. How chemical potentials of different phases depend on temperature and pressure: deriving a T-p phase diagram for water. Additional restrictions from the phase diagram: the Clausius-Clapeyron equation and Gibbs' phase rule. The Concentration Dependence of Chemical Potential, Mixing, and Reactions The dependence of chemical potential on concentration. A simple lattice model for nonideal solution behavior. Chemical reactions Similarities (and differences) between free energies of reaction and mixing. How chemical equilibrium depends on temperature How chemical equilibrium depends on pressure Conformational Equilibrium Macromolecular structure. A simple two-state model for conformational transitions. Simultaneous visualization of N and D. The thermal unfolding transition as a way to determine Kfold and G . A simple geometric way to connect Yobs to Kfold. Fitting conformational transitions to analyze the thermodynamics of unfolding. A more realistic model thermal unfolding of proteins: the constant heat capacity model. Measurement of thermal denaturation by differential scanning calorimetry. Chemical denaturation of proteins. APPENDIX 1: Differential Scanning Calorimetry Ensembles that Interact with their Surroundings Heat exchange and the canonical ensemble. The canonical partition function. A canonical ensemble representing a three particle isothermal system. The isothermal isobaric ensemble and Gibbs free energy. Partition Functions for Single Molecules and Chemical Reactions A canonical partition function for a system with one molecule. The relationship between the molecular and canonical partition functions. An isothermal-isobaric molecular partition function. A statistical thermodynamic approach to chemical reaction. The Helix-Coil Transition The noncooperative homopolymer model. The noncooperative heteropolymer model. Coupling between the sites and the basis for cooperativity Coupling between residues through "nearest-neighbor" models Ligand Binding Equilibria from a Macroscopic Perspective Ligand Binding to a single site Practical issues in measuring and analyzing binding curves Binding of multiple ligands A macroscopic representation of multiple ligand binding. The binding polynomial P: a partition function for ligand binding. An example-the macroscopic binding of two ligands. Binding to multiple different ligands: "heterotropic" binding A general framework to represent thermodynamic linkage between multiple independent ligands. Ligand Binding Equilibria from a Microscopic Perspective. An example of general microscopic binding: three ligand binding sites. Simplifications to microscopic binding models. Binding to s identical, independent sites. Binding to two classes of independent sites. Binding to identical coupled sites Explicit structural models for coupling among between binding sites Allostery in ligand binding.
  • (source: Nielsen Book Data)9781439800195 20171023
This book introduces the concepts and practical tools necessary to understand the behavior of biological macromolecules at a quantitative level. It begins by describing biochemical phenomena using principles of classical and statistical thermodynamics. Unlike other books, this text goes beyond theory to explain in detail how the equations are applied to the analysis of experimental measurements. This emphasis on real-world applications is continued throughout and is a major feature of the book.
(source: Nielsen Book Data)9781439800195 20171023
EBSCOhost Access limited to 1 user

7. Biopsychology [2018]

xxiii, 595 pages : color illustrations ; 29 cm
  • What is biopsychology?
  • Foundations of biopsychology
  • Sensory and motor systems
  • Brain plasticity
  • Biopsychology of motivation
  • Disorders of cognition and emotion.
For courses in Physiological Psychology and Biopsychology Explore how the central nervous system governs behavior Biopsychology presents a clear, engaging introduction to biopsychological theory and research through a unique combination of biopsychological science and personal, reader-oriented discourse. Original author John Pinel and new co-author Steven Barnes address students directly and interweave the fundamentals of the field with clinical case studies, useful metaphors, and memorable anecdotes that make course material personally and socially relevant to readers. In addition to expanded learning objectives that guide students through the course, the Tenth Edition has been thoroughly updated to reflect this rapidly progressing scientific field. Available to package with Biosychology, Tenth Edition, MyLab(TM) Psychology is an online homework, tutorial, and assessment program designed to work with this text to engage students and improve results. MyLab Psychology is ideal for courses requiring robust assessments. Biosychology, Tenth Edition is also available via Revel(TM), an interactive digital learning environment that replaces the print textbook, enabling students to read, practice, and study in one continuous experience. Revel is ideal for courses where student engagement and mobile access are important. Note: You are purchasing a standalone product; Pearson MyLab does not come packaged with this content. Students, if interested in purchasing this title with MyLab, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information. 0134743369 / 9780134743363 Biopsychology plus MyLab Psychology with eText - Access Card Package, 10/e Package consists of: 0134203690 / 9780134203690 Biopsychology, 10/e 0134727746 / 9780134727745 MyLab Psychology with eText Access Card .
(source: Nielsen Book Data)9780134203690 20170306
Science Library (Li and Ma)
1 online resource (xix, 445 pages) : illustrations (some color).
  • 1. Targeted Deletion of Hsf1, 2 and 4 Genes in Mice Xiongjie Jin, Binnur Eroglu, Demetrius Moskophidis, and Nahid F. Mivechi 2. Role of Heat Shock Factors in Stress-induced Transcription Murshid, A., Prince T., Ben Lang, and Calderwood, S. K. 3. Monitoring of the Heat Shock Response with a Real-time Luciferase Reporter Toshiki Kijima, Takanori Eguchi, Len Neckers, and Thomas L. Prince 4. Quantitative Profiling of Chaperone/client Interactions with LUMIER Assay Mikko Taipale 5. Measurement of chaperone-mediated effects on Polyglutamine Protein Aggregation by the Filter Trap Assay Maria A.W.H. van Waarde-Verhagen and Harm H. Kampinga 6. Fluorescent-linked Enzyme Chemoproteomic Strategy (FLECS) for Identifying HSP70 Inhibitors Haystead, T.A.J. 7. A High-throughput Screen for Inhibitors of the Hsp90-Chaperone Machine Jason Davenport, Lakshmi Galam, and Robert L. Matts 8. Primary Colorectal Cells Culture as a Translation Research Model Sheah Lin Lee, Nina Claire Dempsey-Hibbert, Dale Vimalachandran, Terence David Wardle, Paul A Sutton, and John H. H. Williams 9. Cell Death and Survival Assays Alexander E. Kabakov and Vladimir L. Gabai 10. Detecting the Potential Pharmacological Synergy of Drug Combination by Viability Assays In Vitro Benjamin K. Gibbs and Carole Sourbier 11. Proteomic Profiling of Hsp90 Inhibitors Sudhakar Voruganti, Jake T. Kline, Maurie J. Balch, Janet Rogers, Robert L. Matts, and Steven D. Hartson 12. Analysis of HspB1 (Hsp27) Oligomerization and Phosphorylation Patterns and its Interaction with Specific Client Polypeptides Andre-Patrick Arrigo 13. Nucleotide Exchange Factors for Hsp70 Chaperones Heike Rampelt, Matthias P. Mayer, and Bernd Bukau 14. Determination of Hsp90 Activity through Activation of Glucocorticoid Receptors in Yeast Michael Reidy 15. Bacterial Hsp90 ATPase Assays Joel R. Hoskins, Sue Wickner, and Shannon M. Doyle 16. Detecting Post-translational Modifications of Hsp90 Rebecca A. Sager, Mark R. Woodford, Len Neckers, and Mehdi Mollapour 17. Chromatin Immunoprecipitation (ChIP) of Heat Shock Protein 90 (Hsp90) Aneliya Yoveva and Ritwick Sawarkar 18. A Workflow Guide to RNA-seq Analysis of Chaperone Function and Beyond Benjamin J. Lang, Kristina M. Holton, Jianlin Gong, and Stuart K. Calderwood 19. Computational Modeling of the Hsp90 Interactions with Cochaperones and Small Molecule Inhibitors Gennady M. Verkhivker 20. Computational Analysis of the Chaperone Interaction Networks Shwani Kumar, Kamran Rizzolo, Sandra Zilles, Mohan Babu, and Walid A. Houry 21. Immunohistochemistry of Human Hsp60 in Health and Disease: From Autoimmunity to Cancer Francesco Cappello, Everly Conway de Macario, Francesca Rappa, Giovanni Zummo, and Alberto J. L. Macario 22. Immunohistochemical and Flow Cytometric Analysis of Intracellular and Membrane-bound Hsp70, as a Putative Biomarker of Glioblastoma Multiforme, using the cmHsp70.1 Monoclonal Antibody Stefan Stangl, Gemma A. Foulds, Helena Fellinger, Geoffrey J. Pilkington, A. Graham Pockley, and Gabriele Multhoff 23. Detection and Analysis of Extracellular Hsp90 (eHsp90) Stephanie Cortes, Alexander Baker-Williams, Mehdi Mollapour, and Dimitra Bourboulia 24. Molecular Chaperone Receptors Ayesha Murshid, Jimmy Theriault, Jianlin Gong, and Stuart K. Calderwood 25. Creation of Recombinant Chaperone Vaccine using Large Heat Shock Protein for Antigen-targeted Cancer Immunotherapy Chunqing Guo, John R. Subjeck, and Xiang-Yang Wang 26. A Novel Heat Shock Protein 70-based Vaccine Prepared from DC-Tumor Fusion Cells Desheng Weng, Stuart K. Calderwood, and Jianlin Gong 27. Hsp70: A Cancer Target Inside and Outside the Cell Christophe Boudesco, Sebastien Cause, Gaetan Jego, and Carmen Garrido 28. Evidence for Hsp90 Cochaperones in Regulating Hsp90 Function and Promoting Client Protein Folding Marc B. Cox and Jill L. Johnson 29. Clinical Evaluation and Biomarker Profiling of Hsp90 Inhibitors Akira Yuno, Min-Jung Lee, Sunmin Lee, Yusuke Tomita, David Rekhtman, Brittni Moore, and Jane B. Trepel.
  • (source: Nielsen Book Data)9781493974764 20180115
This volume is a compilation of laboratory protocols and methodology required for the study of molecular chaperones and the cellular stress response. Chapters detail stress response in Hsf1, Hsf2 and Hsf4 knockout mice, mapping HSP interaction networks, the LUminescence-based Mammalian IntERactome (LUMIER), Hsp70 biology, protein folding activity of Hsp90, cytotoxicity of HSP inhibitors, computational approaches for modeling allosteric Hsp90 interactions, HSPs in immunity and vaccine development , and biologies of Hsp70 and Hsp90. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Chaperones: Methods and Protocols aims to ensure successful results in the further study of this vital field.
(source: Nielsen Book Data)9781493974764 20180115
1 online resource.
  • 1. Introduction to the Complex Connection between Cannabis Use and Psychosis, Psychotic Disorders, and Schizophreniaã ã Marc W. Manseau and Michael T. Compton 2. The Epidemiology of Cannabis Use in the United States ã ã Wilson M. Compton and Beth Han 3. The Biology of Cannabis in the Brain, and the Endocannabinoid System ã ã David Louis Atkinson and Jeff. K. Abbott 4. Psychotomimetic and Cognitive Effects of Î 9-Tetrahydrocannabinol in Laboratory Settings John D. Cahill, Swapnil Gupta, Jose Cortes-Briones, Rajiv Radhakrishnan, Mohamed Sherif, Deepak C. D'Souza 5. Psychotomimetic and Cognitive Effects of Cannabis Use in the General Population ã ã Nadia Solowij 6. Effects of Cannabis Use among those with Schizotypy ã ã Angelo B. Cedeno 7. Effects of Cannabis Use among those at Clinical High Risk for Schizophrenia ã ã Brian O'Donoghue, Meredith McHugh, Barnaby Nelson, and Patrick McGorry 8. Cannabis-Induced Psychotic Disorders ã ã Luca Pauselli 9. Synthetic Cannabinoids and Synthetic Cannabinoid-Induced Psychotic Disorders ã ã Papanti Duccio, Schifano Fabrizio, and Orsolini Laura 10. Cannabis Use as an Independent Risk Factor for, or Component Cause of, Schizophrenia and Related Psychotic Disorders ã ã Jodi M. Gilman, Sara M. Sobolewski, and Anne Eden Evins 11. Cannabis Use as a Determinant of Earlier Age at Onset of Schizophrenia and Related Psychotic Disorders ã ã Claire Ransay Wan and Beth Broussard 12. The Prevalence of Cannabis Use, and Effects on Course and Outcomes, among Individuals with Schizophrenia and Related Psychotic Disordersã ã Ana Fresan, Rebeca Robles-Garcia, and Carlos-Alfonso Tovilla-Zarate 13. The Treatment of Cannabis Use Disorders among Individuals with Psychotic Disorders ã ã Peter Bosanac, Ana Lusicic, and David J. Castle 14. Cannabidiol as a Potential Novel Therapeutic Agent for Psychotic Disorders ã ã Serena Deiana and Erica Zamberletti.
  • (source: Nielsen Book Data)9780128047910 20171017
The Complex Connection between Cannabis and Schizophrenia provides an in-depth overview of the current state of research into the role that cannabis plays in schizophrenia, covering both the pathophysiological and the pharmacological implications. It addresses the epidemiology of cannabis use and the risks associated with its use, the biological aspects of the drug, its effects on the brain and the pharmacological possibilities of using cannabidiol to treat schizophrenia. It is the only book on the market devoted exclusively to examining the links between this very commonly used (and misused) drug and a specific set of devastating psychiatric illnesses, providing a comprehensive guide to our current understandings of this relationship. Marijuana is the most commonly used illicit drug globally, and is becoming increasingly decriminalized and even legalized worldwide. Among the numerous mental-health concerns related to the drug, there is mounting evidence of an intricate link between cannabis use and schizophrenia and related psychotic disorders. At the same time, there is promising evidence to suggest that cannabidiol, one of the many compounds found in cannabis that activates the brain's cannabinoid receptors, could prove to be an effective antipsychotic to treat schizophrenia.
(source: Nielsen Book Data)9780128047910 20171017
1 online resource (xi, 436 pages) : illustrations (some color).
  • Current and future challenges in GPCR drug discovery / Sid Topiol
  • Characterization of ligand binding to GPCRs through computational methods / Silvana Vasile, Mauricio Esguerra, Willem Jespers, Ana Oliveira, Jessica Sallander, Johan Aqvist, and Hugo Gutierrez-de-Teran
  • Breakthrough in GPCR crystallography and its impact on computer-aided drug design / Antonella Ciancetta and Kenneth A. Jacobson
  • Structural framework for GPCR chemogenomics : what's in a residue number? / Marton Vass, Albert J. Kooistra, Stefan Verhoeven, David Gloriam, Iwan J.P. de Esch, and Chris de Graaf
  • GPCR homology model generation for lead optimization / Christofer S. Tautermann
  • GPCRs : what can we learn from molecular dynamics simulations? / Naushad Velgy, George Hedger, and Philip C. Biggin
  • Methods of exploring protein-ligand interactions to guide medicinal chemistry efforts / Paul Labute
  • Exploring GPCR-ligand interactions with the fragment molecular orbital (FMO) method / Ewa I. Chudyk, Laurie Sarrat, Matteo Aldeghi, Dmitri G. Fedorov, Mike J. Bodkin, Tim James, Michelle Southey, Roger Robinson, Inaki Morao, and Alexander Heifetz
  • Molecular basis of ligand dissociation from G protein-coupled receptors and predicting residence time / Dong Guo and Adriaan P. IJzerman
  • Methodologies for the examination of water in GPCRs / Andrea Bortolato, Benjamin G. Tehan, Robert T. Smith, and Jonathan S. Mason
  • Methods for virtual screening of GPCR targets : approaches and challenges / Jason B. Cross
  • Approaches for differentiation and interconverting GPCR agonists and antagonists / Przemysław Miszta, Jakub Jakowiecki, Ewelina Rutkowska Maria Turant, Dorota Latek, and Sławomir Filipek
  • Opportunities and challenges in the discovery of allosteric modulators of GPCRs / Damian Bartuzi, Agnieszka A. Kaczor, and Dariusz Matosiuk
  • Challenges and opportunities in drug discovery of biased ligands / Ismael Rodrıguez-Espigares, Agnieszka A. Kaczor, Tomasz Maciej Stepniewski, and Jana Selent
  • Synergistic use of GPCR modeling and SDM experiments to understand ligand binding / Andrew Potterton, Alexander Heifetz, and Andrea Townsend-Nicholson
  • Computational support of medicinal chemistry in industrial settings / Daniel F. Ortwine
  • Investigating small-molecule ligand binding to G protein-coupled receptors with biased or unbiased molecular dynamics simulations / Kristen A. Marino and Marta Filizola
  • Ligand-based methods in GPCR computer-aided drug design / Paul C.D. Hawkins and Gunther Stahl
  • Computational methods used in hit-to-lead and lead optimization stages of structure-based drug discovery / Alexander Heifetz, Michelle Southey, Inaki Morao, Andrea Townsend-Nicholson, and Mike J. Bodkin
  • Cheminformatics in the service of GPCR drug discovery / Tim James
  • Modeling and deorphanization of orphan GPCRs / Constantino Diaz, Patricia Angelloz-Nicoud, and Emilie Pihan.
xxxv, 326 pages ; 24 cm.
Science Library (Li and Ma)
1 online resource.
  • Introduction.- The construction of a general platform for capillary electrophoresis.- Integrated module for automatic DNA extraction and amplification.- A fully-integrated genetic analysis system.- Conclusion and prospects for future work.
  • (source: Nielsen Book Data)9789811047527 20170925
This thesis reports on the development of a fully integrated and automated microsystem consisting of low-cost, disposable plastic chips for DNA extraction and PCR amplification, combined with a reusable glass capillary array electrophoresis chip, which can be employed in a modular-based format for genetic analysis. In the thesis, DNA extraction is performed by adopting a filter paper-based method, followed by an "in-situ" PCR carried out directly in the same reaction chamber of the chip without elution. PCR products are then co-injected with sizing standards into separation channels for detection using a novel injection electrode. The entire process is automatically carried out by a custom-made compact control and detection instrument. The author thoroughly tests the system's performance and reliability by conducting rapid genetic screening of mutations on congenital hearing loss and pharmacogenetic typing of multiple warfarin-related single-nucleotide polymorphisms. The successful development and operation of this microsystem establishes the feasibility of rapid "sample-in-answer-out" testing in routine clinical practice.
(source: Nielsen Book Data)9789811047527 20170925
1 online resource (x, 315 pages) : illustrations (some color) Digital: text file; PDF.
  • Two-dimensional gel electrophoresis and 2D-DIGE / Paula Meleady
  • Comparative DIGE proteomics / Kay Ohlendieck
  • 2D-DIGE and fluorescence image analysis / Elisa Robotti and Emilio Marengo
  • DIGE analysis software and protein identification approaches / Abduladim Hmmier and Paul Dowling
  • Native DIGE : efficient tool to elucidate protein interactomes / Diksha Dani and Norbert A. Dencher
  • Comparative two-dimensional fluorescence gel electrophoresis / Doreen Ackermann and Simone Konig
  • DIGE-based phosphoproteomic analysis / Taras Stasyk and Lukas Alfons Huber
  • DIGE saturation labeling for scarce amounts of protein from formalin-fixed paraffin-embedded (FFPE) tissue / Paul Dowling
  • Comparative 3-sample DIGE analysis of skeletal muscles / Kay Ohlendieck
  • DIGE analysis of ProteoMiner fractionated serum/plasma samples / Sandra Murphy and Paul Dowling
  • DIGE analysis of human tissues / Cecilia Gelfi and Daniele Capitanio
  • DIGE analysis of animal tissues / Alessio Di Luca, Ruth Hamill, Anne Maria Mullen, and Giuliano Elia
  • Rapid 2D DIGE proteomic analysis of mouse liver / Shotaro Kamata and Isao Ishii
  • Proteomic analysis of lung tissue by DIGE / Jarlath E. Nally and Simone Schuller
  • Comparative testis tissue proteomics using 2-dye versus 3-dye DIGE analysis / Ashling Holland
  • DIGE analysis of fish tissues / Joanna Nynca, Mariola A. Dietrich, and Andrzej Ciereszko
  • Protein digestion for DIGE analysis / Sandra Murphy and Kay Ohlendieck
  • Subcellular fractionation for DIGE-based proteomics / Sandra Murphy
  • DIGE analysis of immunodepleted plasma / Paul Dowling and Kay Ohlendieck
  • Elucidating cellular metabolism and protein difference data from DIGE proteomics experiments using enzyme assays / Andrew Dowd
  • Enzyme assay methods to validate DIGE proteomics data / Andrew Dowd
  • Immunoblot analysis of DIGE-based proteomics / Martin Landsberger and Heinrich Brinkmeier
  • Immunofluorescence microscopy for DIGE-based proteomics / Rustam R. Mundegar, Margit Zweyer, and Dieter Swandulla.
This volume provides a comprehensive study of this key method of gel-based proteomics. Chapters in Difference Gel Electrophoresis: Methods and Protocols detail methods on principles of differential protein labeling, two-dimensional gel electrophoresis, techniques on optimized proteomic workflows, advanced mass spectrometry for protein identification, application of basic biological research, and applied biomarker discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Difference Gel Electrophoresis: Methods and Protocols aims to ensure successful results in the further study of this vital field.
(source: Nielsen Book Data)9781493972678 20171211
1 online resource (216 p.) : ill. (some col.).
"This book is intended for non-specialists and students, presenting a unique introduction to the field of DNA nanotechnology. The primary focus is on the extraordinary advantages of specificity and sensitivity obtained by integrating DNA nanostructures in bioanalytical devices. DNA Nanotechnology for Bioanalysis provides a concise and rigorous description for the fabrication of various types of functional nanostructures by optimized software-aided high-yield synthesis. Following this is the explanation of methods to decorate these nanostructures with molecules such as proteins, metal nanoparticles or bioorganic moieties covalently bonded onto DNA via self-assemblage processes. Also provided is a concise review on non-canonical DNA structures (such as G-quadruplexes) and their targeting by small molecules for applications in pharmacology. Finally, it describes the exciting applications of DNA nanostructures in life sciences and nanomedicine, including ultraspecific molecular delivery, control of cell behavior, analysis of cell lysate and DNA-based nano-tools for super-resolution sub-cellular imaging."--Publisher's website.
1 online resource (xi, 328 pages) : illustrations (some color).
  • Preface...Table of Contents...Contributing Authors...1- Type IA DNA Topoisomerases: A Universal Core and Multiple ActivitiesFlorence Garnier, Helene Debat, and Marc Nadal2- Topoisomerase I and Genome Stability: The Good and The BadJang-Eun Cho and Sue Jinks-Robertson3- DNA Topoisomerases as Targets for Antibacterial AgentsHiroshi Hiasa4- DNA Supercoiling Measurement in BacteriaYingting Liu, Zhi-Chun Hua, and Fenfei Leng5- DNA Catenation Reveals the Dynamics of DNA Topology during ReplicationAlicia Castan, Pablo Hernandez, Dora B. Krimer, and Jorge B. Schvartzman6- Mapping E. coli Topoisomerase IV Binding and Activity SitesHafez El Sayyed and Olivier Espeli7- The Use of Psoralen Photobinding to Study Transcription-Induced SupercoilingFedor Kouzine, Laura Baranello, and David Levens8- Immunoprecipitation of RNA:DNA Hybrids from Budding YeastAziz El Hage and David Tollervey9- Detection of oriC-Independent Replication in Escherichia coli CellsMakisha Martel, Aurelien Balleydier, Julien Brochu, and Marc Drolet10- Single-Molecule Magnetic Tweezer Analysis of TopoisomerasesKathryn H. Gunn, John F. Marko, and Alfonso Mondragon11- Synthesis of Hemicatenanes for the Study of Type IA TopoisomerasesShun-Hsiao Lee, Tao-shih Hsieh, and Grace Ee-Lu Siaw12- An Assay for Detecting RNA Topoisomerase ActivityMuzammil Ahmad, Dongyi Xu, and Weidong Wang13- Studying TDP1 Function in DNA RepairShih-Chieh Chiang, Kirsty Liversidge, and Sherif F. El-Khamisy14- Topoisomerase II Chromatin ImmunoprecipitationKayleigh A. Smith, Ian G. Cowell, and Caroline A. Austin15- Analyzing Mitotic Chromosome Structural Defects after Topoisomerase II Inhibition or MutationJuan F. Gimenez-Abian, Andrew B. Lane, and Duncan J. Clarke16- Monitoring the DNA Topoisomerase II Checkpoint in Saccharomyces cerevisiaeKatherine Furniss, Amit C. J. Vas, Andrew Lane, and Duncan J. Clarke17- Studying Topoisomerase 1-Mediated Damage at Genomic RibonucleotidesJessica S. Williams and Thomas A. Kunkel18- A Fluorescence-Based Assay for Identification of Bacterial Topoisomerase I PoisonsThirunavukkarasu Annamalai, Bokun Cheng, and Yuk-Ching Tse-Dinh19- Fluoroquinolone-Gyrase-DNA Cleaved ComplexesGan Luan and Karl Drlica20- Detection of Topoisomerase Covalent Complexes in Eukaryotic CellsJay Anand, Yilun Sun, Yang Zhao, Karin C. Nitiss, and John L. Nitiss21- Visualization and Quantification of Topoisomerase-DNA Covalent Complexes Using the Trapped in Agarose Immunostaining (TARDIS) AssayIan G. Cowell and Caroline A. Austin22- Study of Plasmid-Mediated Quinolone Resistance in BacteriaGeorge A. Jacoby.
  • (source: Nielsen Book Data)9781493974580 20180115
This volume looks at the evolution of the topo field over the last year and discusses how DNA topoisomerases are directly and indirectly involved in numerous cellular processes. The chapters in this book cover various topics, such as type 1 topos with an evolutionary perspective; antimicrobial agents targeting topos; experimental protocols related to DNA topology, including a basic technique to measure DNA supercoiling in bacteria; protocols for in vitro studies, including assays to detect RNA topo activity; topo inhibitors; and a study of plasmid-mediated quinolone resistance in bacteria. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, DNA Topoisomerases: Methods and Protocols is intended for specialists and non-specialists with an overview of selected hot topics in the field, and the latest protocols to study DNA topology, topoisomerases functions and inhibition by various compounds.
(source: Nielsen Book Data)9781493974580 20180115
xxxviii, 478 pages : color illustrations ; 23 cm
Each new print copy includes Navigate 2 Advantage Access that unlocks a comprehensive and interactive eBook, student practice activities and assessments, a full suite of instructor resources, and learning analytics reporting tools Foundations of Kinesiology provides a guided introduction to the discipline and professions of kinesiology using a holistic, learner-centered, and skill-based approach. The text explores the core subdisciplines of kinesiology and allows students to explore the research and physical activity contributions that each has to offer. The text also considers how the discipline is crucial in enabling healthy lives by illustrating real-life scenarios across several chapters. The learner-centered approach stresses the importance of active engagement and social interaction in the students' own construction of knowledge, fostering long-term retention of the content, increased motivation, and higher achievement. In using Foundations of Kinesiology, students will have the opportunity to develop the skills necessary to achieve their personal and professional goals while becoming advocates for meaningful physical activity and lifelong learning. With Navigate 2, technology and content combine to expand the reach of your classroom. Whether you teach an online, hybrid, or traditional classroom-based course, Navigate 2 delivers unbeatable value. Experience Navigate 2 today at www.jblnavigate.com/2. KEY FEATURES: - Incorporates three core approaches to learning: holistic, learner-centered, and skill-based - Utilizes a personal, approachable style in which the authors act as mentors to students familiarizing themselves with the discipline - Stop and Think boxes provide questions to help students better grasp the importance of certain topics.
(source: Nielsen Book Data)9781284034851 20170403
Science Library (Li and Ma)

17. Human biology [2018]

1 volume (various pagings) : color illustrations, color maps ; 28 cm
  • 1 Exploring Life and Science Unit 1 Human Organization 2 Chemistry of Life 3 Cell Structure and Function 4 Organization and Regulation of Body Systems Unit 2 Maintenance of the Human Body 5 Cardiovascular System: Heart and Blood Vessels 6 Cardiovascular System: Blood 7 The Lymphatic and Immune Systems 8 Infectious Diseases 9 Digestive System and Nutrition 10 Respiratory System 11 Urinary System Unit 3 Movement and Support in Humans 12 Skeletal System 13 Muscular System Unit 4 Integration and Coordination in Humans 14 Nervous System 15 Senses 16 Endocrine System Unit 5 Reproduction in Humans 17 Reproductive System 18 Development and Aging Unit 6 Human Genetics 19 Patterns of Chromosome Inheritance 20 Cancer 21 Patterns of Genetic Inheritance 22 DNA Biology and Technology Unit 7 Human Evolution and Ecology 23 Human Evolution 24 Ecology and the Nature of Ecosystems 25 Human Interactions with the Biosphere.
  • (source: Nielsen Book Data)9781259689796 20170327
Overview Instructors consistently ask for a Human Biology textbook that helps students understand the main themes of biology through the lens of the human body. Mader's Human Biology, 15th Edition accomplishes the goal of improving scientific literacy, while establishing a foundation of knowledge inhuman biology and physiology. The text integrates a tested, traditional learning system with modern digital and pedagogical approaches designed to stimulate and engage today's student. Dr. Michael Windelspecht represents the new generation of digital authors. Through the integration of an array of multimedia resources, Michael has committed to delivering the tried-and-true content of the Mader series to the new generation of digital learners. A veteran of the online, hybrid, and traditional teaching environments, Michael is well-versed in the challenges facing the modern student and educator.
(source: Nielsen Book Data)9781259689796 20170327
Science Library (Li and Ma)
p. ; [ca. 23-29] cm
  • No TOC, it is an alphabetical listing of compounds.
  • (source: Nielsen Book Data)9781351730686 20171218
Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor. From antibiotics to statins, modern medicine relies on the reliability and ease-of-use of enzyme- and receptor-directed inhibitors and antagonists.The Inhibitor Index is a comprehensive, curated compendium of over 7,800 enzyme inhibitors and receptor antagonists, including many toxins, poisons, and metabolic uncouplers.
(source: Nielsen Book Data)9781351730686 20171218
xvii, 501 pages : illustrations (some color) ; [ca. 23-29] cm.
  • Citrus Variety and Cultivation in the World. Polysaccharides in Citrus. Phenolic Components in Citrus. Terpenes in Citrus. Carotenoids in Citrus. Properties of Citrus Flavonoids. Neuroprotective Effects of Citrus Flavonoids. Functional Foods Based on Citrus Fruits and Extracts Developed in Italy. Some Minor Bioactive Components in Citrus. Citrus Processing and New Products in Spain. Citrus Products.
  • (source: Nielsen Book Data)9781498742740 20171218
Citrus fruits have long been popular around the world due to their good flavor, taste, high nutritional value, and their healthy properties. Citrus is well known as a rich source of vitamin C. Citrus fruits also contain many other functional bioactive phytochemicals including terpenoids, triterpenes, flavonoids, amino acids, phenolic acids, mineral constituents, and polysaccharides, which are beneficial to human health. Citrus fruits are generally recognized as an outstanding source of biologically active compounds related to both nutritional and nutraceutical values. Phytochemicals in Citrus: Applications in Functional Foods focuses on up-to-date information on chemical properties of citrus fruits, citrus food products, and their health benefits. The 16 chapters in the book provide a knowledge base on the chemical composition, bioactive components, biochemical properties, food use, and health benefits of citrus fruits. The information in this book will help readers to better understand the health benefits of citrus fruits and products and their dietary applications. The book is a unique reference for food science professionals engaged in functional foods and nutritional dietary management. The book can also serve as a handy reference for college and university students majoring in food science, nutrition, pharmaceutical science, and horticultural science.
(source: Nielsen Book Data)9781498742740 20171218
1 online resource (xv, 512 pages) : illustrations (some color).