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A scientist assesses the potential of stem cell therapies for treating such brain disorders as stroke, Alzheimer's disease, and Parkinson's disease. Stem cell therapies are the subject of enormous hype, endowed by the media with almost magical qualities and imagined by the public to bring about miracle cures. Stem cells have the potential to generate new cells of different types, and have been shown to do so in certain cases. Could stem cell transplants repair the damaged brain? In this book, neurobiologist Jack Price assesses the potential of stem cell therapies to treat such brain disorders as stroke, Alzheimer's disease, Parkinson's disease, and spinal cord injuries. Certainly brain disorders are in need of effective treatments. These disorders don't just kill, they disable, and conventional drug therapies have not had much success in treating them. Price explains that repairing the human brain is difficult, largely because of its structural, functional, and developmental complexity. He examines the self-repairing capacity of blood and gut cells-and the lack of such capacity in the brain; describes the limitations of early brain stem cell therapies for neurodegenerative disorders; and discusses current clinical trials that may lead to the first licensed stem cell therapies for stroke, Parkinson's and macular degeneration. And he describes the real promise of pluripotential stem cells, which can make all the cell types that constitute the body. New technologies, Price reports, challenge the very notion of cell transplantation, instead seeking to convince the brain itself to manufacture the new cells it needs. Could this be the true future of brain repair?
(source: Nielsen Book Data)

• The Cold War
• The Hunt --Outbreak
• Postmortem.

"This true story dives into the mystery surrounding one of the most controversial and misdiagnosed conditions of our time--Lyme disease--and of Willy Burgdorfer, the man who discovered the microbe behind it, revealing his secret role in developing bug-borne biological weapons, and raising terrifying questions about the genesis of the epidemic of tick-borne diseases affecting millions of Americans today. While on vacation on Martha's Vineyard, Kris Newby was bitten by an unseen tick. That one bite changed her life forever, pulling her into the abyss of a devastating illness that took ten doctors to diagnose and years to recover: Newby had become one of the 300,000 Americans who are afflicted with Lyme disease each year. As a science writer, she was driven to understand why this disease is so misunderstood, and its patients so mistreated. This quest led her to Willy Burgdorfer, the Lyme microbe's discoverer, who revealed that he had developed bug-borne bioweapons during the Cold War, and believed that the Lyme epidemic was started by a military experiment gone wrong. In a superb, meticulous work of narrative journalism, Bitten takes readers on a journey to investigate these claims, from biological weapons facilities to interviews with biosecurity experts and microbiologists doing cutting-edge research, all the while uncovering darker truths about Willy. It also leads her to uncomfortable questions about why Lyme can be so difficult to both diagnose and treat, and why the government is so reluctant to classify chronic Lyme as a disease. A gripping, infectious page-turner, Bitten will shed a terrifying new light on an epidemic that is exacting an incalculable toll on us, upending much of what we believe we know about it"-- Provided by publisher.

• Basics of Genetics
• Basic Concepts of Genetics / Pál Perge and Peter Igaz
• Brief Description of Inheritance Patterns / Annamária Kövesdi and Attila Patócs
• Family Screening and Genetic Counseling / Pal Perge and Peter Igaz
• Brief Summary of the Most Important Molecular Genetic Methods (PCR, qPCR, Microarray, Next-Generation Sequencing, etc.) / Henriett Butz and Attila Patócs
• Endocrine Diseases Inherited as Monogenic Traits : Hormone Resistance Syndromes
• Syndromes of Resistance to Thyroid Hormone Action / Luca Persani and Irene Campi
• Glucocorticoid Resistance / Nicolas C. Nicolaides and Evangelia Charmandari
• Endocrine Diseases Inherited as Monogenic Traits : Hereditary Diseases Predisposing to Endocrine Tumors
• Overview of Genetically Determined Diseases, Multiple Endocrine Neoplasia Syndromes Predisposing to Endocrine Tumors / Abel Decmann, Attila Patócs, and Peter Igaz
• Hereditary Diseases Predisposing to Pheochromocytoma (VHL, NF-1, Paraganglioma Syndromes, and Novel Genes) / Balázs Sarkadi and Attila Patócs
• Diseases Predisposing to Adrenocortical Malignancy (Li-Fraumeni Syndrome, Beckwith-Wiedemann Syndrome, and Carney Complex) / Anne Jouinot and Jérôme Bertherat
• Genetics of Pituitary Tumours / Paul Benjamin Loughrey and Márta Korbonits
• Timeline of Advances in Genetics of Primary Aldosteronism / Lucie S. Meyer, Martin Reincke, and Tracy Ann Williams
• Congenital Adrenal Hyperplasia / Dóra Török
• Endocrine Diseases Inherited as Monogenic Traits : Monogenic Diseases Predisposing to Hormone Deficiency, Infertility and Diabetes Mellitus
• Pituitary Transcription Factor Mutations Leading to Hypopituitarism / Peter Gergics
• Hereditary Neurohypophyseal Diabetes Insipidus / Jonas Rutishauser, Nicole Beuret, Cristina Prescianotto-Baschong, and Martin Spiess
• Nephrogenic Diabetes Insipidus / András Balla and László Hunyady
• Monogenic Forms of Male Infertility / Csilla Krausz and Antoni Riera-Escamilla
• Genetic Causes of Female Infertility / Artur Beke
• Monogenic Forms of Diabetes Mellitus / Zsolt Gaál and István Balogh
• Example of a Multifactorial Disease and Chromosomal Alterations in Endocrine Diseases
• Genetics of Obesity / Lotte Kleinendorst, Mieke M. van Haelst, and Erica L. T. van den Akker
• Chromosomal Aberrations with Endocrine Relevance (Turner Syndrome, Klinefelter Syndrome, Prader-Willi Syndrome) / Irén Haltrich

This book provides a comprehensive overview of the genetic basis underlying endocrine diseases. It covers both the molecular and clinical consequences of these genetic defects, as well as the relevance for clinical care, highlighting issues of genetic counseling. Several endocrine diseases have a genetic background, and contemporary research in the field plays a crucial role in the clinical care of endocrine diseases. In recent years, there have been major developments in our understanding of the genetic basis of endocrine diseases. Several novel genes and mutations predisposing individuals to monogenic endocrine diseases have been discovered, and with the advent of next generation sequencing, a huge amount of new data has become available. Further, novel molecular mechanisms, such as genomic imprinting, have been implicated in the pathogenesis of endocrine diseases. A better understanding of the genetic background of these diseases is relevant not only from the research perspective, but also in terms of clinical care. As such, this book is an essential read for both researchers and clinicians working in the field.
(source: Nielsen Book Data)

• Contributors vii Foreword ix Part I Recognition and Control of Hazards 1
• 1. Recognition of Health Hazards in the Workplace 3 Martin R. Horowitz and Marilyn F. Hallock
• 2. Information Resources for Occupational Safety and Health Professionals 37 Ralph Stuart, James Stewart, and Robert Herrick
• 3. Ergonomics: Achieving System Balance Through Ergonomic Analysis and Control 49 Graciela M. Perez
• 4. Evaluation of Exposure to Chemical Agents 89 Jerry Lynch and Charles Chelton
• 5. Statistical Methods for Occupational Exposure Assessment 125 David L. Johnson
• 6. Evaluation and Management of Exposure to Infectious Agents 147 Janet M. Macher, Deborah Gold, Patricia Cruz, Jennifer L. Kyle, Timur S. Durrani, and Dennis Shusterman
• 7. Occupational Dermatoses 199 David E. Cohen
• 8. Indoor Air Quality in Nonindustrial Occupational Environments 231 Philip R. Morey and Richard Shaughnessy
• 9. Occupational Noise Exposure and Hearing Conservation 261 Charles P. Lichtenwalner and Kevin Michael
• 10. Heat Stress 335 Anne M. Venetta Richard and Ralph Collipi, Jr.
• 11. Radiation: Nonionizing and Ionizing Sources 359 Donald L. Haes, Jr., and Mitchell S. Galanek
• 12. Enterprise Risk Management: An Integrated Approach 381 Chris Laszcz-Davis
• 13. Safety and Health in Product Stewardship 425 Thomas Grumbles Part II General Control Practices 435
• 14. Prevention Through Design 437 Frank M. Renshaw
• 15. How to Select and Use Personal Protective Equipment 469 Richard J. Nill
• 16. Respiratory Protective Devices 495 James S. Johnson
• 17. How to Establish Industrial Loss Prevention and Fire Protection 531 Peter M. Bochnak
• 18. Philosophy and Management of Engineering Control 569 Pamela Greenley and William A. Burgess
• 19. Environmental Health and Safety (EHS) Auditing 613 Andrew McIntyre, Harmony Scofield, and Steven Trammell Part III Management Approaches 639
• 20. Addressing Legal Requirements and Other Compliance Obligations 641 Thea Dunmire
• 21. Occupational Safety and Health Management 653 Fred A. Manuele
• 22. Effective Safety and Health Management Systems: Management Roles and Responsibilities 671 Fred A. Manuele
• 23. Safety and Health Management of International Operations 691 S. Z. Mansdorf
• 24. The Systems Approach to Managing Occupational Health and Safety 701 Victor M. Toy Index 717.
• (source: Nielsen Book Data)

A quick, easy-to-consult source of practical overviews on wide-ranging issues of concern for those responsible for the health and safety of workers This new and completely revised edition of the popular Handbook is an ideal, go-to resource for those who need to anticipate, recognize, evaluate, and control conditions that can cause injury or illness to employees in the workplace. Devised as a "how-to" guide, it offers a mix of theory and practice while adding new and timely topics to its core chapters, including prevention by design, product stewardship, statistics for safety and health, safety and health management systems, safety and health management of international operations, and EHS auditing. The new edition of Handbook of Occupational Safety and Health has been rearranged into topic sections to better categorize the flow of the chapters. Starting with a general introduction on management, it works its way up from recognition of hazards to safety evaluations and risk assessment. It continues on the health side beginning with chemical agents and ending with medical surveillance. The book also offers sections covering normal control practices, physical hazards, and management approaches (which focuses on legal issues and workers compensation). Features new chapters on current developments like management systems, prevention by design, and statistics for safety and health Written by a number of pioneers in the safety and health field Offers fast overviews that enable individuals not formally trained in occupational safety to quickly get up to speed Presents many chapters in a "how-to" format Featuring contributions from numerous experts in the field, Handbook of Occupational Safety and Health, 3rd Edition is an excellent tool for promoting and maintaining the physical, mental, and social well-being of workers in all occupations and is important to a company's financial, moral, and legal welfare.
(source: Nielsen Book Data)

• Psychiatric Neuroscience: Challenges and Opportunities in Psychiatric Neuroscience / Joshua A. Gordon, Julie A. Frost Bellgowan, Collene Lawhorn, and Rachel B. Scheinert
• The Neurobiology of Confidence: From Beliefs to Neurons / Torben Ott, Paul Masset, and Adam Kepecs
• Causal Inference on Pathophysiological Mediators in Psychiatry / Ho Namkung, Brian J. Lee, and Akira Sawa

• Neurodevelopment and Synapses: Parvalbumin Interneuron Plasticity for Consolidation of Reinforced Learning / Matteo Tripodi, Komal Bhandari, Ananya Chowdhury, Arghya Mukherjee, and Pico Caroni
• Adolescence and "Late Blooming" Synapses of the Prefrontal Cortex / Kristen Delevich, A. Wren Thomas, and Linda Wilbrecht
• The Synaptomic Theory of Behavior and Brain Disease / Seth G.N. Grant

• Sleep and Neuromodulation: Genetic Mechanisms Underlying Sleep / Hirofumi Toda, Mi Shi, Julie A. Williams, and Amita Sehgal
• Brain Circuitry for Arousal from Apnea / Clifford B. Saper and Satvinder Kaur
• Computational Underpinnings of Neuromodulation in Humans / P. Read Montague and Kenneth T. Kishida
• Multiple Dopamine Systems: Weal and Woe of Dopamine / Mitsuko Watabe-Uchida and Naoshige Uchida

• Social Behavior: Neuropeptidergic Control of an Internal Brain State Produced by Prolonged Social Isolation Stress / Moriel Zelikowsky, Keke Ding, and David J. Anderson
• The Hippocampus and Social Impairment in Psychiatric Disorders / Matthew Schafer and Daniela Schiller
• Nucleus Accumbens Modulation in Reward and Aversion / Anna M. Klawonn and Robert C. Malenka

• Neurological Health: Epigenetic Priming in Drug Addiction / Philipp Mews, Deena M. Walker, and Eric J. Nestler
• Decoding Depression: Insights from Glial and Ketamine Regulation of Neuronal Burst Firing in Lateral Habenula / Yihui Cui, Yan Yang, Yiyan Dong, and Hailan Hu
• Improving Mouse Models for Dementia. Are All the Effects in Tau Mouse Models Due to Overexpression? / Zelah Joel, Pablo Izquierdo, Dervis A. Salih, Jill C. Richardson, Damian M. Cummings, and Frances A. Edwards
• Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases / Michel Goedert, Benjamin Falcon, Wenjuan Zhang, Bernardino Ghetti, and Sjors H.W. Scheres

• Treatments: Rewiring the Addicted Brain: Circuits-Based Treatment for Addiction / Graziella Madeo and Antonello Bonci
• Investigating the Therapeutic Mechanism of Cannabidiol in a Human Induced Pluripotent Stem Cell (iPSC)-Based Model of Dravet Syndrome / Yishan Sun and Ricardo E. Dolmetsch
• A Network Explanation of Alzheimer's Regional Vulnerability / Scott A. Small and Larry W. Swanson
• Current Status of Deep Brain Stimulation for Alzheimer's Disease: From Chance Observation to Clinical Trials / Darrin J. Lee and Andres M. Lozano
• Benefits of Enhancing Nicotinamide Adenine Dinucleotide Levels in Damaged or Diseased Nerve Cells / Andrew A. Pieper and Steven L. McKnight

• Dorcas Cummings Lecture: Dorcas Cummings Lecture

• Conversations at the Symposium: A Conversation with Edward Boyden
• A Conversation with Yang Dan
• A Conversation with Ricardo Dolmetsch
• A Conversation with Paul Glimcher
• A Conversation with Michel Goedert
• A Conversation with Joshua A. Gordon
• A Conversation with Adam Kepecs
• A Conversation with Robert C. Malenka
• A Conversation with Helen Mayberg
• A Conversation with P. Read Montague
• A Conversation with Michael Platt
• A Conversation with Daniela Schiller
• A Conversation with Scott Small
• A Conversation with Beth Stevens
• A Conversation with Li-Huei Tsai
• A Conversation with Kay Tye
• A Conversation with Mehmet Fatih Yanik
• A Conversation with Huda Zoghbi

Summary: Order and Disorder in Brains and Behavior
"Topics addressed at the Symposium included the cellular basis of neurodegeneration, memory systems and aging, neural circuits of anxiety, addiction circuits and treatment frontiers, sleep and sleep disorders,hormonal regulation and mood disorders, cortico-striatal circuits in perception and action, deep brain stimulation for psychiatry, computational psychiatry, development of social cognition, restoration of vision, brainmachine interfaces, and new techniques for human brain manipulation."--Foreword

• Introduction Acknowledgements List of abbreviations Companion website Anatomical and functional organization
• 1 Development of the nervous system
• 2 Organization of the nervous system
• 3 Autonomic nervous system
• 4 Enteric nervous system
• 5 Meninges and cerebrospinal fluid
• 6 Blood supply to the central nervous system
• 7 Cranial nerves
• 8 Anatomy of the brainstem
• 9 Organization of the spinal cord
• 10 Organization of the cerebral cortex and thalamus
• 11 Hypothalamus Cells and neurophysiology
• 12 Cells of the nervous system I: neurones
• 13 Cells of the nervous system II: neuroglial cells
• 14 Ion channels
• 15 Resting membrane and action potential
• 16 Neuromuscular junction and synapses
• 17 Nerve conduction and synaptic integration
• 18 Neurotransmitters, receptors and their pathways
• 19 Main CNS neurotransmitters and their function
• 20 Skeletal muscle structure
• 21 Skeletal muscle contraction Sensory systems
• 22 Sensory systems: an overview
• 23 Sensory transduction
• 24 Visual system I: the eye and retina
• 25 Visual system II: the visual pathways and subcortical visual areas
• 26 Visual system III: visual cortical areas
• 27 Auditory system I: the ear and cochlea
• 28 Auditory system II: auditory pathways and language
• 29 Vestibular system
• 30 Olfaction and taste
• 31 Somatosensory system
• 32 Pain systems I: nociceptors and nociceptive pathways
• 33 Pain systems II: pharmacology and management
• 34 Association cortices: the posterior parietal and prefrontal cortex Motor systems
• 35 Organization of the motor system
• 36 Muscle spindle and lower motor neurone
• 37 Spinal cord motor organization and locomotion
• 38 Cortical motor areas
• 39 Primary motor cortex
• 40 Basal ganglia: anatomy and physiology
• 41 Basal ganglia: diseases and their treatments
• 42 Cerebellum Cognition and neural plasticity
• 43 Reticular formation and sleep
• 44 Limbic system and long-term potentiation
• 45 Memory
• 46 Emotion, motivation and drug addiction
• 47 Neural plasticity and neurotrophic factors I: the peripheral nervous system
• 48 Neural plasticity and neurotrophic factors II: the central nervous system
• 49 Techniques for studying the nervous system Applied neurobiology: the principles of neurology and psychiatry
• 50 Approach to the patient with neurological problems
• 51 Examination of the nervous system
• 52 Investigation of the nervous system
• 53 Imaging of the central nervous system
• 54 Clinical disorders of the sensory systems
• 55 Clinical disorders of the motor systems
• 56 Eye movements
• 57 Neurochemical disorders I: affective disorders
• 58 Neurochemical disorders II: schizophrenia
• 59 Neurochemical disorders III: anxiety
• 60 Neurodegenerative disorders
• 61 Neurophysiological disorders: epilepsy
• 62 Neuroimmunological disorders
• 63 Neurogenetic disorders
• 64 Cerebrovascular disease
• 65 Neuroradiological anatomy History of neuroscientific discoveries
• 66 Historical neuroscience discoveries Self-assessment case studies Case studies and questions Answers Index.
• (source: Nielsen Book Data)

Everything you need to know about Neuroanatomy and Neuroscience at a Glance! Neuroanatomy and Neuroscience at a Glance is a highly illustrated, quick reference guide to the anatomy, biochemistry, physiology and pharmacology of the human nervous system. Each chapter features a summary of the anatomical structure and function of a specific component of the central nervous system, a section on applied neurobiology outlining how to approach a patient with neurological or psychiatric problems aligned to the chapter topic, standard diagnostic procedures for most common scenarios, as well as an overview of treatment and management options. This fully updated and expanded new edition includes: Dozens of full-page, colour illustrations and neurological scansExpanded coverage of techniques to study the nervous systemMore practical information on the neurological examNew content on neuropharmacology and drug therapiesBullet points and bold terms throughout assist with revision and review of the topic Neuroanatomy and Neuroscience at a Glance is the ideal companion for students embarking on a neuroanatomy or neuroscience course, and is an excellent reference tool for those in clinical training.An updated companion website with new clinical cases, multiple choice self-assessment questions, revision slides, and downloadable illustrations and flashcards is available at www.ataglanceseries.com/neuroscience.
(source: Nielsen Book Data)

• Complex Numbers-- Matrices-- Vectors-- Vector Calculus-- Tensor Analysis-- Probability and Statistics-- Waves-- Fourier Transforms-- Classical Mechanics-- Special Relativity-- Electric and Magnetic Fields-- The Magnetic Moment and the Bloch Equations-- Quantum Mechanics-- The Hamiltonians of NMR-- The Quantum Mechanics of Angular Momentum-- NMR Rotation Operators-- Density Operators-- The Product Operator Formalism-- Relaxation and the NOE-- Data Processing-- Coherence Transfer-- Electronics-- Appendices.
• (source: Nielsen Book Data)

Beginning with a review of the important areas of mathematics, this book then covers many of the underlying theoretical and practical aspects of NMR and MRI spectroscopy from a maths point of view. Competence in algebra and introductory calculus is needed but all other maths concepts are covered. It will bridge a gap between high level and introductory titles used in NMR or MRI spectroscopy. Uniquely, it takes a very careful and pedagogical approach to the mathematics behind NMR and MRI. It leaves out very few steps, which distinguishes it from other books in the field. The author is an NMR laboratory manager and is sympathetic to the frustrations of trying to understand where some of the fundamental equations come from hence his desire to either explicitly derive all equations for the reader or direct them to derivations. This is an essential text aimed at graduate students who are beginning their careers in NMR or MRI spectroscopy and laboratory managers if they need an understanding of the theoretical foundations of the technique.
(source: Nielsen Book Data)

Exercise, Sport, and Bioanalytical Chemistry: Principles and Practice focuses on the basic and applied aspects of energy metabolism in humans. Concise and scientific, yet intelligible to the nonscientist, the book consists of two parts. Part I, Introduction: Basics and Background, provides the biochemistry necessary to understand the rest of the book and describes analytical processes and results as an aid to grasping the science. Part II, Applications: Knowledge into Practice, explores measurement techniques for metabolism, energy expenditure of various activities, techniques that enhance expenditure, metabolic adaptation, foods and drugs that enhance expenditure, and the role of bioanalytical chemistry in future research in exercise and sport. Discussion of the benefits of exercise and practices for improving the capacity to perform exercise is illustrated by many useful and entertaining examples. This volume allows readers to come away with a grasp of the scientific concepts, how they are manifested in research techniques, and how the results of research can be applied in the real world of public health and personal development. * Provides readers with the fundamental biochemistry and some elements of the physiology behind physical activity/exercise and describes the analytical techniques used to elucidate the science* Written in clear, concise, compelling prose that is neither simplistic to scientists nor too sophisticated for a large, diverse global audience* A one-page Close-Up in each chapter illustrates key topics to catch, engage, entertain, and create a novel synthesis of thought.
(source: Nielsen Book Data)

Reflecting changes in the current health and safety landscape, Occupational Health and Safety Management: A Practical Approach, Third Edition includes examples and tools to facilitate development and implementation of a safety and health management approach. This how-to book is not just an information providing text. It shows you how to write a program and identify hazards as well as involve workers and attain their cooperation. It emphasizes the need for better and more effective communication regarding safety and health. See What's New in the Third Edition: * Chapters on workers' compensation, terrorism, and Lean safety/sustainability * Additional coverage of flammable liquids and ventilation, accident reporting, and accident investigation * New compliance requirements as well as expanded accident investigation, environmental, and risk analysis guidelines * PowerPoint presentation slides for each chapter A complete and practical guide for the development and management of occupational safety and health programs in any industry setting, the book supplies a management blueprint that can be used for occupational safety and health in any organization, from the smallest to the largest, beginning to develop or wanting to improve its safety and health approach. It includes comprehensive guidelines for development of occupational health and safety programs to a variety of industries and is especially useful for start-up companies. The author takes a total management approach to the development of written programs, the identification of hazards, the mitigation of hazards by the use of common safety and health tools, the development of a safe workforce through communications, motivational techniques, involvement, and training. He addresses the tracking and acceptable risk from both safety and health hazards. He also discusses how to work with and within the OSHA compliance approach as well as how to deal with the OSHA regulations, workers' compensation, terrorism, and Lean safety. As you understand and apply the guidelines in each chapter, you can put your company on the way toward building a successful and effective safety and health effort for its employers and employees.
(source: Nielsen Book Data)

• Part I: Origins. The fall ; Crumpled lead and rippled copper ; Dream jobs ; The bridge ; Arline
• Part II: Madness. Pomander walk ; Water, fire, electricity ; Melius anceps remedium quam nullum ; The broken ; Room 2200 ; Sunset Hill ; Experiment successful, but the patient died ; Unlimited access ; Ecphory ; The vacuum and the ice pick
• Part III: The hunt. It was brought into the sea ; Proust on the operating table ; Fortunate misfortunes ; Henry Gustave Molaison (1926-1953)
• Part IV: Discovery. Where angels fear to tread ; Monkeys and men ; Interpreting the stars ; The son-of-a-bitch center ; The MIT research project known as the amnesic patient H.M.
• Part V: Secret wars. Dewey defeats Truman ; A sweet, tractable man ; It is necessary to go to Niagara to see Niagara Falls ; Patient H.M. (1953-2008) ; The smell of bone dust ; Every day is alone in itself ; Postmortem.

"In the summer of 1953, a renowned Yale neurosurgeon named William Beecher Scoville performed a novel operation on a 27-year-old epileptic patient named Henry Molaison, drilling two silver-dollar sized holes in his forehead and suctioning out a few teaspoons of tissue from a mysterious region deep inside his brain. The operation helped control Molaison's intractable seizures, but it also did something else: It left Molaison amnesic for the rest of his life, with a short term memory of just thirty seconds. Patient H.M., as he came to be known, would emerge as the most important human research subject in history. Much of what we now know about how memory works is a direct result of the sixty years of near-constant experimentation carried out upon him until his death in 2008. Award-winning journalist Luke Dittrich brings readers from the gleaming laboratory in San Diego where Molaison's disembodied brain -- now the focus of intense scrutiny -- sits today; to the surgical suites of the 1940s and 50s, where doctors wielded the powers of gods; and into the examination rooms where generations of researchers performed endless experiments on a single, essential, oblivious man: H.M.. In the process, Dittrich excavates the lives of Dr. Scoville and his most famous patient, and spins their tales together in thrilling, kaleidoscopic fashion, uncovering troves of well-guarded secrets, and revealing how the bright future of modern neuroscience has dark roots in the forgotten history of psychosurgery, raising ethical questions that echo into the present day"-- Provided by publisher.

• Before parasites were cool
• Hitching a ride
• Zombified
• Hypnotized
• Dangerous liaisons
• Gut feelings
• My microbes made me fat
• Healing instinct
• The forgotten emotion
• Parasites and prejudice
• Parasites and piety
• The geography of thought.

"Based on a wildly popular Atlantic article: an astonishing investigation into the world of microbes, and the myriad ways they control how other creatures -- including humans -- act, feel, and think As we are now discovering, parasites -- microbes that cannot thrive and reproduce without another organism as a host -- are shockingly sophisticated and extraordinarily powerful. In fact, a plethora of parasites affect our behavior in ways we have barely begun to understand. In this mind-bending book, McAuliffe reveals the eons-old war between parasites and other creatures that is playing out in our very own bodies. And more surprising still, she uncovers the decisive role that parasites may have played in the rise and demise of entire civilizations. Our obsession with cleanliness and our experience of disgust are both evolutionary tools for avoiding infection, but they evolved differently for different populations. Political, social, and religious differences among societies may be caused, in part, by the different parasites that prey on us. In the tradition of Jared Diamond's Guns, Germs, and Steel and Neil Shubin's Your Inner Fish, This Is Your Brain on Parasites is both a journey into cutting-edge science and a revelatory examination of what it means to be human."-- Provided by publisher.

Through the vivid, true stories of five people who journeyed into and out of addiction, a renowned neuroscientist explains why the "disease model" of addiction is wrong and illuminates the path to recovery. The psychiatric establishment and rehab industry in the Western world have branded addiction a brain disease, based on evidence that brains change with drug use. But in The Biology of Desire, cognitive neuroscientist and former addict Marc Lewis makes a convincing case that addiction is not a disease, and shows why the disease model has become an obstacle to healing. Lewis reveals addiction as an unintended consequence of the brain doing what it's supposed to do-seek pleasure and relief-in a world that's not cooperating. Brains are designed to restructure themselves with normal learning and development, but this process is accelerated in addiction when highly attractive rewards are pursued repeatedly. Lewis shows why treatment based on the disease model so often fails, and how treatment can be retooled to achieve lasting recovery, given the realities of brain plasticity. Combining intimate human stories with clearly rendered scientific explanation, The Biology of Desire is enlightening and optimistic reading for anyone who has wrestled with addiction either personally or professionally.
(source: Nielsen Book Data)

• FOOT AND ANKLE JOINT
• Foot Model for Investigating Foot Biomechanics and Footwear Design-- Ming Zhang, Jia Yu, Yan Cong, Yan Wang, and Jason Tak-Man Cheung
• Female Foot Model for High-Heeled Shoe Design-- Jia Yu and Ming Zhang
• Foot and Ankle Model for Surgical Treatment-- Yan Wang and Ming Zhang
• First Ray Model Comparing Normal and Hallux Valgus Feet-- Duo Wai-Chi Wong, Ming Zhang, and Aaron Kam-Lun Leung
• Dynamic Foot Model for Impact Investigation-- Jia Yu, Duo Wai-Chi Wong, and Ming Zhang
• KNEE JOINT
• Knee Joint Model for Anterior Cruciate Ligament Reconstruction-- Jie Yao and Yubo Fan
• Knee Joint Models for Kneeling Biomechanics-- Yuxing Wang, Yubo Fan, and Ming Zhang
• Knee Implant Model: A Sensitivity Study of Trabecular Stiffness on Periprosthetic Fracture-- Duo Wai-Chi Wong and Ming Zhang
• HIP AND PELVIS
• Femur Model for Predicting Strength and Fracture Risk-- He Gong, Yubo Fan, and Ming Zhang
• Hip Model for Osteonecrosis-- Duo Wai-Chi Wong, Zhihui Pang, Jia Yu, Aaron Kam-Lun Leung, and Ming Zhang
• Pelvis Model for Reconstruction with Autografted Long Bones Following Hindquarter Amputation-- Wen-Xin Niu, Jiong Mei, Ting-Ting Tang, Yu-Bo Fan, Ming Zhang, and Ming Ni
• LOWER LIMB FOR REHABILITATION
• Foot-Ankle-Knee Model for Foot Orthosis-- Xuan Liu and Ming Zhang
• Lower Residual Limb for Prosthetic Socket Design-- Winson C.C. Lee and Ming Zhang
• Residual Limb Model for Osteointegration-- Winson C.C. Lee
• SPINE
• Spine Model for Vibration Analysis-- Lixin Guo, Ming Zhang, and Ee-Chon Teo
• Cervical Spinal Fusion and Total Disc Replacement-- Zhongjun Mo, LiZhen Wang, Ming Zhang, and Yubo Fan
• Spine Model for Disc Replacement-- Qi Li, Lizhen Wang, Zhongjun Mo, and Yubo Fan
• Spine Model for Applications in Aviation Protection-- Cheng-fei Du, Lizhen Wang, Ya-wei Wang, and Yubo Fan
• HEAD AND HAND
• Head Model for Protection-- Lizhen Wang, Peng Xu, Xiaoyu Liu, Zhongjun Mo, Ming Zhang, and Yubo Fan
• Tooth Model in Orthodontics and Prosthodontics-- Chao Wang, Yi Zhang, Wei Yao, and Yubo Fan
• Eye Model and Its Application-- Xiaoyu Liu, Lizhen Wang, Deyu Li, and Yubo Fan
• Temporomandibular Joint Model for Asymptomatic and Dysfunctional Joints-- Zhan Liu, Yuan-li Zhang, Ying-li Qian, and Yubo Fan
• Fingertip Model for Blood Flow and Temperature-- Ying He, Hongwei Shao, Yuanliang Tang, Irina Mizeva, and Hengdi Zhang
• BONE
• Micro-Finite Element Model for Bone Strength Prediction-- He Gong, Ming Zhang, and Ling Qin
• Simulation of Osteoporotic Bone Remodeling-- He Gong, Yubo Fan, and Ming Zhang
• Index.
• (source: Nielsen Book Data)

Computational biomechanics is an emerging research field that seeks to understand the complex biomechanical behaviors of normal and pathological human joints to come up with new methods of orthopedic treatment and rehabilitation. Computational Biomechanics of the Musculoskeletal System collects the latest research and cutting-edge techniques used in computational biomechanics, focusing on orthopedic and rehabilitation engineering applications. The book covers state-of-the-art techniques and the latest research related to computational biomechanics, in particular finite element analysis and its potential applications in orthopedics and rehabilitation engineering. It offers a glimpse into the exciting potentials for computational modeling in medical research and biomechanical simulation. The book is organized according to anatomical location-foot and ankle, knee, hip, spine, and head and teeth. Each chapter details the scientific questions/medical problems addressed by modeling, basic anatomy of the body part, computational model development and techniques used, related experimental studies for model setup and validation, and clinical applications. Plenty of useful biomechanical information is provided for a variety of applications, especially for the optimal design of body support devices and prosthetic implants. This book is an excellent resource for engineering students and young researchers in bioengineering. Clinicians involved in orthopedics and rehabilitation engineering may find this work to be both informative and highly relevant to their clinical practice.
(source: Nielsen Book Data)

• Part 1 General Considerations in Clinical Medicine
• Part 2 Cardinal Manifestations and Presentation of Diseases
• Section 1 Pain
• Section 2 Alterations in Body Temperature
• Section 3 Nervous System Dysfunction
• Section 4 Disorders of Eyes, Ears, Nose, and Throat
• Section 5 Alterations in Circulatory and Respiratory Functions
• Section 6 Alterations in Gastrointestinal Function
• Section 7 Alterations in Renal and Urinary Tract Function
• Section 8 Alterations in Sexual Function and Reproduction
• Section 9 Alterations in the Skin
• Section 10 Hematologic Alterations
• Part 3 Genes, the Environment, and Disease
• Part 4 Regenerative Medicine
• Part 5 Aging
• Part 6 Nutrition and Weight Loss
• Part 7 Oncology and Hematology
• Section 1 Neoplastic Disorders
• Section 2 Hematopoietic Disorders
• Section 3 Disorders of Hemostasis
• Part 8 Infectious Diseases
• Section 1 Basic Considerations in Infectious Diseases
• Section 2 Clinical Syndromes: Community-Acquired Infections
• Section 3 Clinical Syndromes: Health Care-Associated Infections
• Section 4 Approach to Therapy for Bacterial Diseases
• Section 5 Diseases Caused by Gram-Positive Bacteria
• Section 6 Diseases Caused by Gram-Negative Bacteria
• Section 7 Miscellaneous Bacterial Infections
• Section 8 Mycobacterial Diseases
• Section 9 Spirochetal Diseases
• Section 10 Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
• Section 11 Viral Diseases: General Considerations
• Section 12 Infections Due to DNA Viruses
• Section 13 Infections Due to DNA and RNA Respiratory Viruses
• Section 14 Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
• Section 15 Infections Due to RNA Viruses
• Section 16 Fungal Infections
• Section 17 Protozoal and Helminthic Infections: General Considerations
• Section 18 Protozoal Infections
• Section 19 Helminthic Infections
• Part 9 Terrorism and Clinical Medicine
• Part 10 Disorders of the Cardiovascular System
• Section 1 Introduction to Cardiovascular Disorders
• Section 2 Diagnosis of Cardiovascular Disorders
• Section 3 Disorders of Rhythm
• Section 4 Disorders of the Heart
• Section 5 Coronary and Peripheral Vascular Disease
• Part 11 Disorders of the Respiratory System
• Section 1 Diagnosis of Respiratory Disorders
• Section 2 Diseases of the Respiratory System
• Part 12 Critical Care Medicine
• Section 1 Respiratory Critical Care
• Section 2 Shock and Cardiac Arrest
• Section 3 Neurologic Critical Care
• Section 4 Oncologic Emergencies
• Part 13 Disorders of the Kidney and Urinary Tract
• Part 14 Disorders of the Gastrointestinal System
• Section 1 Disorders of the Alimentary Tract
• Section 2 Liver and Biliary Tract Disease
• Section 3 Disorders of the Pancreas
• Part 15 Immune-Mediated, Inflammatory, and Rheumatologic Disorders
• Section 1 The Immune System in Health and Disease
• Section 2 Disorders of Immune-Mediated Injury
• Section 3 Disorders of the Joints and Adjacent Tissues
• Part 16 Endocrinology and Metabolism
• Section 1 Endocrinology
• Section 2 Reproductive Endocrinology
• Section 3 Obesity, Diabetes Mellitus, and Metabolic Syndrome
• Section 4 Disorders of Bone and Mineral Metabolism
• Part 17 Neurologic Disorders
• Section 1 Diagnosis of Neurologic Disorders
• Section 2 Diseases of the Central Nervous System
• Section 3 Nerve and Muscle Disorders
• Section 4 Chronic Fatigue Syndrome
• Section 5 Psychiatric and Addiction Disorders
• Part 18 Poisoning, Drug Overdose, and Envenomation
• Part 19 Disorders Associated with Environmental Exposures APPENDIX: Laboratory Values of Clinical Importance Index.
• (source: Nielsen Book Data)

The landmark text that has defined internal medicine for generations of clinicians and students - completely updated with a more streamlined, functional presentation Through six decades, no resource has matched the encyclopedic scope, esteemed scholarship, and scientific rigor of Harrison's Principles of Internal Medicine. Both an educational tool and a clinical reference, it remains one of the most widely read and universally respected textbooks in all of medical publishing and the pinnacle of current medical knowledge. The Nineteenth Edition of Harrison's features a new slimmer presentation, logically divided into two volumes. Volume 1 covers essential foundational-level material on the basic principles underlying optimal patient care and assessment of signs and symptoms. Volume 2 is devoted to specific diseases and the best evidence based approaches to their management. Capturing the countless advances and developments across the full span of medicine, this edition of Harrison's offers a complete update of all content related to pathophysiology and pathophysiology, clinical trials, evidence-based practice guidelines, current diagnostic methods, and established and new treatment methods. NEW chapters on important topics such as Men's Health, Fatigue, Management of Heart Failure, Infertility, and Contraception Increased number of clinical decision trees, radiographic examples, clinical images, tables and summary lists Presented in two volumes: Volume 1 is devoted to cardinal manifestations of disease and approach to differential diagnosis; Volume 2 covers specific diseases and disorders.
(source: Nielsen Book Data)

The Well-Tuned Brain is a call to action. Swept along by the cascading advances of today's technology, most of us take for granted that progress brings improvement. Despite spectacular material advance, however, the evidence grows that we are failing to create a sustainable future for humanity. We are out of tune with the planet that nurtures us. Technology itself is not the problem, as Whybrow explains, but rather our behavior. Throughout its evolution the ancient brain that guides us each day has been focused on short-term survival. But fortunately we are intensely social creatures. Without the caring behaviors that flow from intimate attachments to others, we would be relying on a brain that is only marginally adapted to the complexity of the problems we must now face together. Today we must grapple with survival, not in its immediacy but over the long term. The first step in finding our way forward is to reexamine who we are as creatures of this planet. To this end, Whybrow takes us on a fascinating tour of self-discovery, drawing extensively upon his decades of experience as a psychiatrist and his broad knowledge of neuroscience and human behavior. Illustrated throughout with engaging personal stories, the book's trove of cutting-edge science is enriched by philosophical, historical, and cultural perspectives. What emerges is a summons to rediscover the essential virtues of earlier nurturing, of mentored education, and an engagement with the natural world through curiosity and imagination. Neuroscience can open the search for a better future. But technology alone will not save us. To achieve success we will need the strength and wisdom of our better nature as humane social beings.
(source: Nielsen Book Data)

• CONTENTS
• 1. The Biology and Genetics of Cells and Organisms
• 2. The Nature of Cancer
• 3. Tumor Viruses
• 4. Cellular Oncogenes
• 5. Growth Factors, Receptors, and Cancer
• 6. Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer
• 7. Tumor Suppressor Genes
• 8. pRb and Control of the Cell Cycle Clock
• 9. p53 and Apoptosis: Master Guardian and Executioner
• 10. Eternal Life: Cell Immortalization and Tumorigenesis
• 11. Multi-step Tumorigenesis
• 12. Maintenance of Genomic Integrity and the Development of Cancer
• 13. Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis
• 14. Moving Out: Invasion and Metastasis
• 15. Crowd Control: Tumor Immunology and Immunotherapy
• 16. The Rational Treatment of Cancer.
• (source: Nielsen Book Data)

Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world. The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology. The new Second Edition has been comprehensively revised and updated to include major advances in cancer biology over the past six years. Updates include current information on: * The tumor microenvironment * Metastatic dissemination * Tumor immunology * Cancer stem cells * The epithelial-mesenchymal transition * Multi-step tumorigenesis * Invasion and metastasis * Mutation of cancer cell genomes * Greatly expanded treatment of traditional therapy * Epigenetic contributions * MicroRNA involvement * The Warburg effect Besides its value as a textbook, The Biology of Cancer is a useful reference for individuals working in biomedical laboratories and for clinical professionals. Every copy of the book comes with an updated "Pathways in Human Cancer" poster and a DVD-ROM containing the book's art program, a greatly expanded selection of movies, audio file mini-lectures, Supplementary Sidebars, and a Media Guide.
(source: Nielsen Book Data)