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"The signature undertaking of the Twenty-Second Edition was clarifying the QC practices necessary to perform the methods in this manual. Section in Part 1000 were rewritten, and detailed QC sections were added in Parts 2000 through 7000. These changes are a direct and necessary result of the mandate to stay abreast of regulatory requirements and a policy intended to clarify the QC steps considered to be an integral part of each test method. Additional QC steps were added to almost half of the sections."--Pref. p. iv.

"Organic Syntheses describes checked and edited experimental procedures, spanning a broad range of synthetic methodologies, and provides chemists with a compendium of new or little known experimental procedures which lead to useful compounds or that illustrate important new developments in methodology. For every procedure, safety warnings are presented along with detailed descriptions for the preparation, purification, and identification of the compound in question. Additionally, special reaction conditions are detailed, along with the source of reagents, helpful waste disposal guidelines, discussions of results, references to the primary literature, and an appendix of nomenclature and registry numbers."--Publisher's website.

Based on the Gmelin handbook of inorganic and organometallic chemistry, CrossFire Gmelin is the world's largest compilation of inorganic and organometallic compounds and related physical properties. It answers informatics needs in the material science, catalyst, and semiconductor industries. The database contains over 2.2 million compounds, more than 1.7 million reactions, and 1.1 million citations, including titles and abstracts from 1995. It is fully searchable by structures, substructures, and reactions. The data are indexed from 62 journals. With simple queries, more than 800 chemical and physical data fields, including electric, magnetic, thermal, crystal, and physiological data can be accessed to provide relevant answer sets. Updated quarterly. MDL's partner in the development of CrossFire Gmelin is Gesellschaft Deutscher Chemiker e. V. (GDCh), the German Chemical Society. GDCh is the largest chemistry-related scientific society in continental Europe. It holds the ownership of the data and actively participates in the excerption and the development of CrossFire Gmelin.