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online resource : color illustrations
The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models of human disease.
Medical Library (Lane)
online resource (xvii, 179 pages)
  • Research ethics
  • The ethical perspective
  • The 3rs and good scientific practice
  • Applying ethical thinking and social relevance
  • Regulation and legislation : overview and background
  • Public involvement : how and why?
  • The future of animal research : guesstimates on technical and ethical developments
  • New refine.
Medical Library (Lane)
online resource (xii126 pages)
  • 1. Issues in animal experimentation
  • Aims
  • Definitions
  • Scope
  • 2. A history of animal experimentation
  • The origins of vivisection in Europe
  • Prevailing humanist attitudes to animals
  • The rise of modern biomedical studies
  • 3. Opposition to animal experimentation
  • Introduction
  • Early opposition
  • Utilitarianism and the rise of popular concern
  • Revolution during the nineteenth century
  • Beyond Britain : opposition in the USA into the twentieth century
  • 4. The moral status of animals
  • On the moral status of animals
  • Moral arguments based on reason
  • Ethics ; room for emotion?
  • Moral stewardship
  • Summary
  • 5. Animal use
  • How are animals used?
  • Fundamental and applied biological research
  • Genetic alteration
  • Behavioural [behavioral] research
  • Education and training
  • Production of useful biological and therapeutic materials
  • Product testing
  • 6. The regulation of experiments
  • Laws governing humane use of laboratory animals
  • United Kingdom
  • Australia and New Zealand
  • United States of America
  • 7. Seeking alternatives
  • Introduction
  • Replacement, reduction and refinement
  • Alternatives to non-human vertebrates in scientific research
  • 8. A future without animal experimentation?
  • The construction of modern research institution
  • Absolute replacement or relative replacement?
  • Conclusion
  • Ethical guidelines for students in laboratory classes involving the use of animal tissues.
An essential book for all those who conduct animal-based research or are involved in education and training, as well as regulators, supporters, and opponents alike. This fully updated third edition includes discussion of genetically altered animals and associated welfare and ethical issues that surround the breeding programmes in animal based research. The book discusses the origins of vivisection, the advances in human and non-human welfare made possible by animal experimentation, moral objections, and alternatives to the use of animals in research. It also examines the regulatory umbrella under which experiments are conducted in Europe, USA and Australasia. The author highlights the future responsibilities of researchers who will be working with animals, and offers practical advice on experimental design, literature search, consultation with colleagues, and the importance of the ongoing search for alternatives.
Medical Library (Lane)

4. Animal influenza [2017]

online resource (xvi, 634 pages) : illustrations (some color), map ; 27 cm
  • Influenza A virus / David L. Suarez
  • Diagnostics and surveillance methods / Erica Spackman, David L. Suarez and Giovanni Cattoli
  • The economics of animal influenza / Anni McLeod and Jan Hinrichs
  • Trade and food safety aspects for animal influenza viruses / David E. Swayne
  • Public health implications of animal influenza viruses / Nancy Cox, Sue Trock and Tim Uyeki
  • The innate and adaptive immune response to avian influenza virus / Lonneke Vervelde and Darrell R. Kapczynski
  • Wild bird infections and the ecology of avian influenza viruses / David Stallknecht and Justin Brown
  • The global nature of avian influenza / David E. Swayne
  • Multi-continental panzootic of H5 highly pathogenic avian influenza (1996-2015) / Les Sims and Ian Brown
  • High pathogenicity avian influenza outbreaks since 2008 except multi-continental panzootic of H5 goose/guangdong-lineage viruses / Ian Brown, Celia Abolnik, Juan Garcia-Garcia, Sam McCullough, David E. Swayne and Giovanni Cattoli
  • Low pathogenicity avian influenza / Daniel Perez and J.J. (Sjaak) deWit
  • Epidemiology of avian influenza in agricultural and other man-made systems / Les Sims, John Weaver and David E. Swayne
  • Pathobiology of avian influenza in domestic ducks / Mary Pantin-Jackwood
  • Avian influenza control strategies / Les Sims and David E. Swayne
  • Vaccines and vaccination for avian influenza in poultry / David E. Swayne and Darrell R. Kapczynski
  • The disease, pathobiology and epidemiology of influenza infections in pigs / Susan E. Detmer
  • Immunity, diagnosis and intervention strategies of influenza infections in pigs / Montserrat Torremorell
  • Global evolution of influenza A viruses in swine / Amy Vincent, Nicola Lewis and Richard Webby
  • Vaccines and vaccination for swine influenza : differing situations in Europe and the USA / Kristine van Reeth, Amy L. Vincent and Kelly Lager
  • The disease, pathobiology and epidemiology of influenza infections in horses / Gabrielle A, Landolt and Thomas M. Chambers
  • Vaccines and vaccination to control equine influenza / Thomas M. Chambers
  • Canine influenza / Colin R. Parrish and Edward J. Dubovi
  • Sporadic influenza A virus infections of miscellaneous mammal species / Edwin J.B. Veldhuis Kroeze and Thijs Kuiken
  • Mammalian experimental models and implications in understanding zoonotic potential / Jessica A. Belser and Terrence M. Tumpey.
Medical Library (Lane)

5. bioRxiv [digital] [2017 - ]

online resource (database)
"bioRxiv (pronounced "bio-archive") is a free online archive and distribution service for unpublished preprints in the life sciences. It is operated by Cold Spring Harbor Laboratory, a not-for-profit research and educational institution. By posting preprints on bioRxiv, authors are able to make their findings immediately available to the scientific community and receive feedback on draft manuscripts before they are submitted to journals. Articles are not peer-reviewed, edited, or typeset before being posted online."-- Website.
Medical Library (Lane)
online resource (xviii, 185 pages)
Medical Library (Lane)
online resource (xvii, 307 pages) : illustrations, maps
"Ethnoprimatology, the combining of primatological and anthropological practice and the viewing of humans and other primates as living in integrated and shared ecological and social spaces, has become an increasingly popular approach to primate studies in the twenty-first century. Offering an insight into the investigation and documentation of human-nonhuman primate relations in the Anthropocene, this book guides the reader though the preparation, design, implementation, and analysis of an ethnoprimatological research project, offering practical examples of the vast array of methods and techniques at chapter level. With contributions from the world's leading experts in the field, Ethnoprimatology critically analyses current primate conservation efforts, outlines their major research questions, theoretical bases and methods, and tackles the challenges and complexities involved in mixed-methods research. Documenting the spectrum of current research in the field, it is an ideal volume for students and researchers in ethnoprimatology, primatology, anthropology, and conservation biology"-- Provided by publisher.
Medical Library (Lane)

8. Gnotobiotics [2017]

online resource (xiii, 414 pages) : illustrations (chiefly color)
Medical Library (Lane)
xvii, 196 pages ; color illustrations ; 24 cm
  • Terms and definitions
  • Understanding anesthetic related equipment
  • Anesthetic pharmacology and research related anesthetic considerations
  • Management of anesthesia
  • Anesthesia monitoring
  • Special techniques and species
  • Pain management
  • Euthanasia
  • Regulatory management of rodent anesthesia.
Medical Library (Lane)
xi, 372 pages : illustrations ; 24 cm
  • Drosophila Malpighian tubules: a model for understanding kidney development, function, and disease / Naveen Kumar Gautam, Puja Verma, and Madhu G. Tapadia
  • Zebrafish pronephros development / Richard W. Naylor, Sarah S. Qubisi, and Alan J. Davidson
  • Zebrafish as a model of kidney disease / Elvin E. Morales and Rebecca A. Wingert
  • Use of Xenopus frogs to study renal development/repair / Shoshoni T. Droz and Kelly A. McLaughlin
  • Tissue-specific functions of p53 during kidney development / Zubaida Saifudeen
  • Growth factor regulation in the nephrogenic zone of the developing kidney / Leif Oxburgh, Sree Deepthi Muthukrishnan, and Aaron Brown
  • Development and diseases of the collecting duct system / Lihe Chen, Paul J. Higgins, and Wenzheng Zhang
  • Origin and function of the renal stroma in health and disease / Christopher J. Rowan, Sepideh Sheybani-Deloui, and Norman D. Rosenblum
  • Imaging, analysing and interpreting branching morphogenesis in the developing kidney / Kieran M. Short and Ian M. Smyth
  • Genetic syndromes affecting kidney development / Abhijeet Pal and Kimberly J. Reidy
  • Primary cilia in cystic kidney disease / Prachee Avasthi, Robin L. Maser, and Pamela V. Tran
  • Inflammation and fibrosis in polycystic kidney disease / Cheng Jack Song, Kurt A. Zimmerman, Scott J. Henke, and Bradley K. Yoder
  • Epithelial to mesenchymal transition (EMT) and endothelial to mesenchymal transition (EndMT): role and implications in kidney fibrosis / Ana S. Cruz-Solbes and Keith Youker.
Medical Library (Lane)
online resource (xiii, 196 pages) : illustrations (chiefly color)
  • An Introduction to Pathology Techniques / Elizabeth McInnes
  • Recording Pathology Data / Cheryl L Scudamore
  • General Pathology and the Terminology of Basic Pathology / Elizabeth McInnes
  • Common Spontaneous and Background Lesions in Laboratory Animals / Elizabeth McInnes
  • Target Organ Pathology / Elizabeth McInnes
  • Clinical Pathology / Barbara Beust
  • Adversity: A Pathologist's Perspective / Bhanu Singh
  • Limitations of Pathology and Animal Models / Natasha Neef.
Medical Library (Lane)
online resource (xxiii, 419 pages, [8] unnumbered pages of supplemental images) : illustrations.
  • Polyploidy in animal development and disease / Jennifer L. Bandura and Norman Zielke
  • Large-scale programmed genome rearrangements in vertebrates / Jeramiah J. Smith
  • Chromosome instability in stem cells / Paola Rebuzzini, Maurizio Zuccotti, Carlo Alberto Redi and Silvia Garagna
  • Mechanisms of induced inheritable genome variation in flax / Christopher A Cullis
  • Environmentally induced genome instability and its inheritance / Andrey Golubov
  • The mitochondrial genome, genomic shifting and genomic conflict / Gregory G. Brown
  • Plastid genome stability and repair / Eric Zampini, Sebastien Truche, Etienne Lepage, Samuel Tremblay-Belzile , and Normand Brisson
  • RNA-mediated somatic genome rearrangement in ciliates / John R. Bracht
  • Somatic genome instability in yeast and other fungi / Adrianna Skoneczna and Marek Skoneczny
  • Genome variation in archaeans, bacteria, and asexually reproducing eukaryotes / Xiu-Qing Li
  • RNA polyadenylation site regions : highly similar in base composition pattern but diverse in sequence : a combination ensuring similar function but avoiding repetitive-regions-related genomic instability / Xiu-Qing Li and Donglei Du
  • Insulin signaling pathways in humans and plants / Xiu-Qing Li and Tim Xing
  • Developmental variation in the nuclear genome primary sequence / Xiu-Qing Li
  • Ploidy variation of the nuclear, chloroplast, and mitochondrial genomes in somatic cells / Xiu-Qing Li, Benoit Bizimungu, Guodong Zhang, and Huaijun Si
  • Molecular mechanisms of somatic genome variation / Xiu-Qing Li
  • Hypotheses for interpreting somatic genome variation / Xiu-Qing Li
  • Impacts of somatic genome variation on genetic theories and breeding concepts / Xiu-Qing Li
  • Somatic genome variation : what it is and what it means for agriculture and human health / Xiu-Qing Li.
Medical Library (Lane)
online resource (xx, 226 pages) : illustrations (some color).
  • Preface / Tara Mahfoud, Sam McLean and Nikolas Rose
  • Vital brains: on the entanglement of media, minds, and models / Cornelius Borck
  • Slicing the cortex to study mental illness: Alois Alzheimer's pictures of equivalence / Lara Keuck
  • Opaque models: using drugs and dreams to explore the neurobiological basis of mental phenomena / Nicolas Langlitz
  • Man not a machine: models, minds, and mental labor, c.1980 / Max Stadler
  • Infrastructural intelligence: contemporary entanglements of neuroscience and AI / Johannes Bruder
  • Learning from large-scale neural simulations / Maria Serban
  • Connectomes as constitutively epistemic objects: critical perspectives on modeling in current neuroanatomy / Philipp Haueis, Jan Slaby
  • Bridging the gap between system and cell: the role of ultra-high field MRI in human neuroscience / Robert Turner, Daniel De Haan.
Medical Library (Lane)
online resource (xx, 251 pages) : illustrations (chiefly color)
  • Chapter 1. Introduction
  • Chapter 2. Ethical aspects of the use of animals in translational research
  • Chapter 3. Study design
  • Chapter 4. Improving external validity of experimental animal data
  • Chapter 5. How to end selective reporting in animal research
  • Chapter 6. A comprehensive overview of mouse models in oncology
  • Chapter 7. Mouse models of advanced spontaneous metastasis for experiemental therapeutics
  • Chapter 8. Spontaneous animal tumor models
  • Chapter 9. Dog models of naturally occurring cancer
  • Chapter 10. Improving preclincal cancer models: lessons from human and canine clinical trials of metronomic chemotherapy .
Medical Library (Lane)
online resource (xv, 152 pages) : illustrations (chiefly color)
  • 1. Animal models of herpes keratitis
  • 2. Animal models of cataracts
  • 3. Animla models of glaucoma
  • 4. Animal models of age-related macular degeneration: subretinal inflammation
  • 5. Animal models of diabetic retinopathy
  • 6. Animal models of autoimmune uveitis
  • 7. Animal models of retinitis pigmentosa (RP)
  • 8. An animla model of Graves' orbitopathy
  • 9. Animal models of ocular tumors
  • 10. Epilogue
  • Index.
Medical Library (Lane)
online resource (ix, 123 pages) : color illustrations
  • 1. Source, distribution, and ages of pudgy and non-affected mice.
  • 2. Whole mount preparations
  • 3. Radiographic studies
  • 4. Histologic studies
  • 5. Computerized three-dimensional reconstructions
  • 6. Previous studies on chick vertebral development and human congenital scoliosis
  • 1. Gross appearance
  • 2. Whole mount appearances
  • 3. Radiographic studies
  • 4. Histology studies: vertebrae, ribs, intervertebral discs and ganglia
  • 5. Computerized three-dimensional reconstructions
  • 6. Chick embryo vertebral development
  • 7. Radiology and histopathology of human congenital scoliosis spine
  • ion
  • 3. The pudgy mouse
  • 4. Genetic influences on axial development; mutations identified in mouse models with vertebral deformation
  • 5. Congenital scoliosis (human); its similarity with pudgy mouse vertebral abnormalities
  • 6. Pathogenesis of pudgy and human congenital scoliosis based on histopathologic studies.-V. CONCLUSIONS
  • 1. Implications of pudgy vertebral abnormalities for biologic research
  • 2. Implications of pudgy vertebral abnormalities for clinical patient treatment. .
Medical Library (Lane)
xvi, 484 pages : illustrations (some color) ; 25 cm
  • Preface
  • Fishy hearing: a short biography of Arthur N. Popper
  • A most interesting man of science: the life and research of Richard Rozzell Fay
  • It started in Hawai'I Kai: reminiscences of 43 years (and counting) of collaboration and friendship.- A soliloquy for Art and Dick by Robert J. Dooling
  • Acoustic communication in butterfly fishes: Anatomical novelties, physiology, evolution and behavioral ecology
  • Convergent aspects of acoustic communication in darters, scuplins and gobies
  • Directional hearing and sound source localization in fishes
  • Revisiting psychoacoustic methods for the assessment of fish hearing
  • Hearing in cavefishes
  • What the toadfish ear tells the toadfish brain about sound
  • Comparison of electrophysiological auditory measures in fishes
  • The potential overlapping roles of the ear and lateral line in driving 'acoustic' responses
  • Multimodal sensory input in the utricle and lateral line of the toadfish, Opsanus tau
  • The development of structure and sensitivity of the fish inner ear
  • Peripheral hearing structures in fishes: diversity and sensitivity of catfishes and cichlids by Friedrich Ladich
  • Diversity of inner ears in fishes: possible contribution towards hearing improvements and evolutionary considerations
  • Causes and consequences of sensory hair cell damage and recovery in fishes
  • Chemical ototoxicity of the fish inner ear and lateral line
  • Neuroanatomical evidence for catecholamines as modulators of audition and acoustic behavior in a vocal teleost.
Fish Hearing and Bioacoustics is an anthology of review papers that were presented at a special symposium to honor Arthur Popper and Richard Fay on May 25th 2013 at the Mote Marine Laboratory in Sarasota, FL. The research presentations at this conference spanned the range of disciplines covered by Fay and Popper during their long and productive careers. The book includes the following thematic areas for the papers in this special volume: morphology and anatomy of the inner ear and lateral line systems; physiology of inner ear, lateral line, and central auditory systems; acoustically mediated behavior, including communication and sound localization; and environmental influences on fish hearing and bioacoustics, including anthropogenic effects of noise on fishes. Each chapter reviews and summarizes the past studies of particular area that will lead the reader up to the current work presented at the symposium. In addition, each chapters includes a perspective of how Arthur Popper and Richard Fay have influenced their particular area of fish bio acoustic research. Each manuscript also includes a hypotheses for future studies. These hypotheses will provide a springboard for future work in each field.
Medical Library (Lane)

18. Fish vaccines [2016]

online resource (v, 180 pages) : color illustrations
  • Fish disease causing economic impact in global aquaculture
  • Overview of the fish adaptive immune system
  • Development of fish vaccines
  • focusing on methods
  • Adjuvants and delivery methods -current and novel
  • Fish vaccines
  • the regulatory process and requirements from the laboratory bench to a final commercial product, including field trials
  • Methods for measuring efficacy, safety and potency of fish vaccines
  • Potential of DIVA Vaccines for Fish.
Medical Library (Lane)

19. Gene expression commons [2016 - ]

online resource (website)
"Gene Expression Commons is an open platform for absolute gene expression profiling, which provides common reference by global-scale meta analysis of publicly available microarray data. It enables profiling of gene expression itself. Gene Expression Commons is designed as an open platform. You can upload your microarray data, design your model, and control access level."--website.
Medical Library (Lane)
online resource (xiii, 175 pages) : illustrations ; 25 cm
  • Historical overview
  • Types of current genetic markers and genotyping methodologies
  • Advanced animal breeding programs prior to genomic selection
  • Economic evaluation of genetic breeding programs
  • Least squares, maximum likelihood and Bayesian parameter estimation
  • Trait-based genetic evaluation, the mixed model
  • Maximum likelihood and Bayesian estimation of QTL parameters with random effects included in the model
  • Maximum likelihood, restricted maximum likelihood and Bayesian estimation for mixed models
  • Distribution of genetic effects, theory and results
  • The multiple comparison problem
  • Linkage mapping of QTL
  • Linkage disequilibrium mapping of QTL
  • Marker assisted selection, basic strategies
  • Genetic evaluation based on dense marker maps, basic strategies
  • Genetic evaluation based on analysis of genetic evaluations or daughter-yield evaluations
  • Genomic evaluation based on analysis of production records
  • Validation of methods for genomic estimated breeding values
  • Byproducts of Genomic evaluation analysis: pedigree validation and determination
  • Imputation of missing genotypes : methodologies, accuracies, and effects on genomic evaluations
  • Detection and validation of quantitative trait nucleotides (QTN)
  • Future directions and conclusions.
Medical Library (Lane)