Search results

RSS feed for this result

4,024 results

Book
online resource (xv, 152 pages) : illustrations (chiefly color)
  • 1. Animal models of herpes keratitis
  • 2. Animal models of cataracts
  • 3. Animla models of glaucoma
  • 4. Animal models of age-related macular degeneration: subretinal inflammation
  • 5. Animal models of diabetic retinopathy
  • 6. Animal models of autoimmune uveitis
  • 7. Animal models of retinitis pigmentosa (RP)
  • 8. An animla model of Graves' orbitopathy
  • 9. Animal models of ocular tumors
  • 10. Epilogue
  • Index.
Medical Library (Lane)
Book
online resource (ix, 123 pages) : color illustrations
  • I. INTRODUCTION
  • II. MATERIALS AND METHODS
  • 1. Source, distribution, and ages of pudgy and non-affected mice.
  • 2. Whole mount preparations
  • 3. Radiographic studies
  • 4. Histologic studies
  • 5. Computerized three-dimensional reconstructions
  • 6. Previous studies on chick vertebral development and human congenital scoliosis
  • III. RESULTS
  • 1. Gross appearance
  • 2. Whole mount appearances
  • 3. Radiographic studies
  • 4. Histology studies: vertebrae, ribs, intervertebral discs and ganglia
  • 5. Computerized three-dimensional reconstructions
  • 6. Chick embryo vertebral development
  • 7. Radiology and histopathology of human congenital scoliosis spine
  • IV. DISCUSSION
  • ion
  • 3. The pudgy mouse
  • 4. Genetic influences on axial development; mutations identified in mouse models with vertebral deformation
  • 5. Congenital scoliosis (human); its similarity with pudgy mouse vertebral abnormalities
  • 6. Pathogenesis of pudgy and human congenital scoliosis based on histopathologic studies.-V. CONCLUSIONS
  • 1. Implications of pudgy vertebral abnormalities for biologic research
  • 2. Implications of pudgy vertebral abnormalities for clinical patient treatment. .
Medical Library (Lane)
Book
xvi, 484 pages : illustrations (some color) ; 25 cm
  • Preface
  • Fishy hearing: a short biography of Arthur N. Popper
  • A most interesting man of science: the life and research of Richard Rozzell Fay
  • It started in Hawai'I Kai: reminiscences of 43 years (and counting) of collaboration and friendship.- A soliloquy for Art and Dick by Robert J. Dooling
  • Acoustic communication in butterfly fishes: Anatomical novelties, physiology, evolution and behavioral ecology
  • Convergent aspects of acoustic communication in darters, scuplins and gobies
  • Directional hearing and sound source localization in fishes
  • Revisiting psychoacoustic methods for the assessment of fish hearing
  • Hearing in cavefishes
  • What the toadfish ear tells the toadfish brain about sound
  • Comparison of electrophysiological auditory measures in fishes
  • The potential overlapping roles of the ear and lateral line in driving 'acoustic' responses
  • Multimodal sensory input in the utricle and lateral line of the toadfish, Opsanus tau
  • The development of structure and sensitivity of the fish inner ear
  • Peripheral hearing structures in fishes: diversity and sensitivity of catfishes and cichlids by Friedrich Ladich
  • Diversity of inner ears in fishes: possible contribution towards hearing improvements and evolutionary considerations
  • Causes and consequences of sensory hair cell damage and recovery in fishes
  • Chemical ototoxicity of the fish inner ear and lateral line
  • Neuroanatomical evidence for catecholamines as modulators of audition and acoustic behavior in a vocal teleost.
Fish Hearing and Bioacoustics is an anthology of review papers that were presented at a special symposium to honor Arthur Popper and Richard Fay on May 25th 2013 at the Mote Marine Laboratory in Sarasota, FL. The research presentations at this conference spanned the range of disciplines covered by Fay and Popper during their long and productive careers. The book includes the following thematic areas for the papers in this special volume: morphology and anatomy of the inner ear and lateral line systems; physiology of inner ear, lateral line, and central auditory systems; acoustically mediated behavior, including communication and sound localization; and environmental influences on fish hearing and bioacoustics, including anthropogenic effects of noise on fishes. Each chapter reviews and summarizes the past studies of particular area that will lead the reader up to the current work presented at the symposium. In addition, each chapters includes a perspective of how Arthur Popper and Richard Fay have influenced their particular area of fish bio acoustic research. Each manuscript also includes a hypotheses for future studies. These hypotheses will provide a springboard for future work in each field.
Medical Library (Lane)
Book
online resource (website)
"Gene Expression Commons is an open platform for absolute gene expression profiling, which provides common reference by global-scale meta analysis of publicly available microarray data. It enables profiling of gene expression itself. Gene Expression Commons is designed as an open platform. You can upload your microarray data, design your model, and control access level."--website.
Medical Library (Lane)
Book
online resource (vii, 160 pages) : illustrations (some color)
  • Taxonomy of Histophilus somni
  • Histophilosis as a Natural Disease
  • Histophilus somni Genomics and Genetics
  • Interactions on Histophilus somni with Host Cells
  • Histophilus somni Surface Proteins
  • Host Immune Response to Histophilus somni
  • The Many Facets of Lipooligosaccharide as a Virulence Factor of Histophilus somni
  • Exopolysaccharide Production and Biofilm Formation by Histophilus somni.
Medical Library (Lane)
Book
online resource (x, 115 pages) : illustrations
  • Introduction: 1 Introduction to the Second Edition
  • The Violence Connection
  • Identification and Assessment: Defining Abuse
  • Sources of Identification of Abuse
  • 2.3 Assessment
  • Intervention: Initial Phase of Therapy: Establishing a Working Relationship
  • Establishing Accountability
  • Interpersonal Skills: Empathy
  • Other Interpersonal Skills
  • Complementary Approaches
  • 4. Appendices: Appendix A: Supplementary Cases
  • Appendix B: Screening Instrument
  • Appendix C: History
  • Appendix D: Animal Hoarding. .
This book provides step-by-step guidance on how to identify, assess and treat adults who have abused animals. The theoretical framework employed is broad, encompassing cognitive behavioral, psychodynamic, attachment, and trauma-based theories. Organized by stages of therapy, the text discusses how to frame the therapy, establish a working relationship, deal with resistance, establishing accountability, clarifying values related to animals, and teaching self-management skills such as empathy, attachment, accommodation, reciprocity and nurturance. Additional materials are included or referenced, including an appendix of cases that illustrate the variety of client presentations and electronic supplementary material demonstrates role-played interviews and a workshop presentation.
Medical Library (Lane)
Book
online resource (xi, 300 pages) : many illustrations (chiefly color)
Medical Library (Lane)
Book
online resource (xii, 112 pages) : illustrations
  • Introduction
  • Invertebrate Aquatic Animals
  • Injuries by Vertebrate Aquatic Animals-Phylum Chordata (Fish, Reptiles and Mammals)
  • Ingestion of Aquatic Venomous Animals: Toxinology, Clinical Aspects and Treatment
  • Bacterial and Fungi Infections in Aquatic Environments.
Medical Library (Lane)
Book
online resource (viii, 296 pages) : illustrations (some color)
  • Part I Re-stenosis Models After Angioplasty
  • Wire-mediated endovascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia
  • Cuff-induced neointima formation in mouse models
  • Ligation of the Mouse Common Carotid Artery
  • Photochemically Induced Endothelial Injury
  • Part II Thrombosis and Hemostasis Models
  • Murine Models of Thrombosis and Hemostasis
  • Part III Transplant-Associated Atherosclerosis
  • Murine Heart Transplantation and Graft Arterial Disease
  • Murine Models of Vein Grafting
  • Part IV Hyperlipidemia-Induced Atherosclerosis
  • Mouse Models of Atherosclerosis
  • Part V Aneurysm in the Aorta
  • Angiotensin II-induced Aortic Aneurysms in Mice
  • Mouse model of abdominal aortic aneurysm induced by CaCl2
  • Mouse models of aortic aneurysm (tentative)
  • Part VI Intracranial Aneurysm Models
  • Technical aspects of mouse intracranial aneurysm model
  • Experimental model of cerebral aneurysms in ovariectomized rats
  • Part VII Vascular Disease in Cerebral Arteries
  • A model of stroke and vascular injury in the brain
  • Part VIII Kawasaki Disease
  • Analysis of Kawasaki disease using a mouse model, CAWS vasculitis in DBA/2 mice, induced with a water-soluble extracellular polysaccharide fraction obtained from Candida albicans.
Medical Library (Lane)
Book
online resource (xii, 287 pages) : illustrations (some color)
Medical Library (Lane)
Book
xii, 123 pages : color illustrations ; 26 cm
  • Historical Background of Pancreatic Islet Isolation / Miriam Ramírez-Domínguez
  • The Different Faces of the Pancreatic Islets / Midhat H.Abdulreda, Rayner Rodriguez-Diaz, Over Cabrera, Alejandro Caicedo, Per-Olof Berggren
  • Isolation of Mouse Pancreatic Islets of Langerhans / Miriam Ramírez-Domínguez
  • Pancreatic Islets: Methods for Isolation and Purification of Juvenile and Adult Pig Islets / Heide Brandhorst, Paul R.V. Johnson, Daniel Brandhorst
  • Isolation of Pancreatic Islets from NonHuman Primates / Dora M. Berman
  • Necessities for a Clinical Islet Program / Wayne John Hawthorne
  • Clinical Islet Isolation / Wayne John Hawthorne, Lindy Jane Williams, Yi Vee Chew
  • Index.
Medical Library (Lane)
Book
online resource (ix, 371 pages) : color illustrations
  • Mouse
  • Rat
  • Hamster
  • Gerbil
  • Guinea pig
  • Rabbit.
Medical Library (Lane)
Book
xx, 407 pages : illustrations (some color) ; 25 cm
  • Introduction / Chantra Eskes, Maurice Whelan
  • Validation in support of internationally harmonised OECD test guidelines for assessing the safety of chemicals / Anne Gourmelon, Nathalie Delrue
  • Regulatory acceptance of alternative methods in the development and approval of pharmaceuticals / Sonja Beken, Peter Kasper, Jan-Willem van der Laan
  • Validation of alternative in vitro methods to animal testing: concepts, challenges, processes and tools / Claudius Griesinger, Bertrand Desprez, Sandra Coecke, Warren Casey, Valérie Zuang
  • Practical aspects of designing and conducting validation studies involving multi-study trials / Sandra Coecke [and others]
  • Validation of computational methods / Grace Patlewicz, Andrew P. Worth, Nicholas Ball
  • Implementation of new test methods into practical testing / Rodger D. Curren, Albrecht Poth, Hans A. Raabe
  • Pathway based toxicology and fit-for-purpose assays / Rebecca A. Clewell [and others]
  • Evidence-based toxicology / Sebastian Hoffmann, Thomas Hartung, Martin Stephens
  • Validation of transcriptomics-based in vitro methods / Raffaella Corvi, Mireia Vilardell, Jiri Aubrecht, Aldert Piersma
  • Ensuring the quality of stem cell-derived in vitro models for toxicity testing
  • Glyn N. Stacey, Sandra Coecke, Anna-Bal Price, Lyn Healy, Paul Jennings, Anja Wilmes&
  • Validation of bioreactor and human-on-a-chip devices for chemical safety assessment
  • Sofia P. Rebelo [and others]
  • Integrated approaches to testing and assessment / Andrew P. Worth, Grace Patlewicz
  • International harmonization and cooperation in the validation of alternative methods / João Barroso [and others]
  • Evolving the principles and practice of validation for new alternative approaches to toxicity testing / Maurice Whelan, Chantra Eskes.
Medical Library (Lane)
Book
online resource (xvi, 328 pages) : illustrations (some color).
  • Preface
  • Vertebrate Vocal Production: An Introductory Overview
  • Fish Sound Production: An Exaptation?
  • Vocal Sound Production and Acoustic Communication in Amphibians and Reptiles
  • Locomotion-Induced Sounds and Sonations: Mechanisms, Communication Function, and Relationship with Behavior
  • Embodied Motor Control of Avian Vocal Production
  • Biophysics of Vocal Production in Mammals
  • Infrasonic and Seismic Communication in the Vertebrates with Special Emphasis on the Afrotheria: An Update and Future Directions
  • Vocal Production by Terrestrial Mammals: Source, Filter, and Function
  • Vocal Learning and Auditory-Vocal Feedback
  • Vertebrate Bioacoustics: Prospects and Open Problems.
Medical Library (Lane)
Book
online resource (xvi, 305 pages, [21] pages of plates : illustrations (some color) ; 25 cm)
  • Embryonic Cell Culture in Zebrafish / C.A. Ciarlo, L.I. Zon
  • Cellular Dissection of Zebrafish Hematopoiesis / D.L. Stachura, D. Traver
  • Second Harmonic Generation Microscopy in Zebrafish / D.C. LeBert, J.M. Squirell, A. Huttenlocher, K.W. Eliceiri
  • Imaging Blood Vessels and Lymphatic Vessels in the Zebrafish / H.M. Jung, S. Isogai, M. Kamei, D. Castranova, A.V. Gore, B.M. Weinstein
  • An Eye on Light-sheet Microscopy / D. Kromm, T. Thumberger, J. Wittbrodt
  • Single Neuron Morphology In Vivo with Confined Primed Conversion / M.A. Mohr, P. Pantazis
  • Visualizing Retinoic Acid Morphogen Gradients / T.F. Schilling, J. Sosnik, Q. Nie
  • Using Fluorescent Lipids in Live Zebrafish Larvae: from Imaging Whole Animal Physiology to Subcellular Lipid Trafficking / J.L. Anderson, J.D. Carten, S.A. Farber
  • Analysis of Cilia Structure and Function in Zebrafish / E. Leventea, K. Hazime, C. Zhao, J. Malicki
  • Functional Calcium Imaging in Zebrafish Lateral-line Hair Cells / Q.X. Zhang, X.J. He, H.C. Wong, K.S. Kindt
  • Physiological Recordings from the Zebrafish Lateral Line / J. Olt, A.J. Ordoobadi, W. Marcotti, J.G. Trapani.
Medical Library (Lane)
Book
online resource (xviii, 642, 20 pages) : illustrations.
Methods to Study Maternal Regulations of Germ Cell Specification in Zebrafish -- Patterning, Morphogenesis, and Neurogenesis of Zebrafish Cranial Sensory Placodes -- Oligodendrocyte Differentiation -- Studying the Peripheral Sympathetic Nervous System and Neuroblastoma in Zebrafish -- Zebrafish As a Model for Understanding Enteric Nervous System Interactions in the Developing Intestional Tract -- Methods to Study the Development, Anatomy, and Function of the Zebrafish Inner Ear Across the Life Course -- Imaging Collective Cell Migration and Hair Cell Regeneration in the Sensory Lateral Line -- Analysis of the Retina in the Zebrafish Model -- Strategies for Analyzing Cardiac Phenotypes in the Zebrafish Embryo -- Chemical Approaches to Angiogenesis in Development and Regeneration -- Quantitative Methods for Studying Hemostasis in Zebrafish Larvae -- Zebrafish Kidney Development -- Zebrafish Pancreas As a Model for Development and Disease -- Endoderm Specification and Liver Development -- Emerging Tools to Study Proteoglycan Function During Skeletal Development -- Generation and Analysis of Zebrafish Melanoma Models -- Learning and Memory in Zebrafish (Danio rerio) -- Working With Zebrafish at Postembryonic Stages.Methods to Study Maternal Regulations of Germ Cell Specification in Zebrafish -- Patterning, Morphogenesis, and Neurogenesis of Zebrafish Cranial Sensory Placodes -- Oligodendrocyte Differentiation -- Studying the Peripheral Sympathetic Nervous System and Neuroblastoma in Zebrafish -- Zebrafish As a Model for Understanding Enteric Nervous System Interactions in the Developing Intestional Tract -- Methods to Study the Development, Anatomy, and Function of the Zebrafish Inner Ear Across the Life Course -- Imaging Collective Cell Migration and Hair Cell Regeneration in the Sensory Lateral Line -- Analysis of the Retina in the Zebrafish Model -- Strategies for Analyzing Cardiac Phenotypes in the Zebrafish Embryo -- Chemical Approaches to Angiogenesis in Development and Regeneration -- Quantitative Methods for Studying Hemostasis in Zebrafish Larvae -- Zebrafish Kidney Development -- Zebrafish Pancreas As a Model for Development and Disease -- Endoderm Specification and Liver Development -- Emerging Tools to Study Proteoglycan Function During Skeletal Development -- Generation and Analysis of Zebrafish Melanoma Models -- Learning and Memory in Zebrafish (Danio rerio) -- Working With Zebrafish at Postembryonic Stages.
Medical Library (Lane)
Book
online resource (xii, 763 pages) : illustrations (some color)
Animal cells are the preferred "cell factories" for the production of complex molecules and antibodies for use as prophylactics, therapeutics or diagnostics. Animal cells are required for the correct post-translational processing (including glycosylation) of biopharmaceutical protein products. They are used for the production of viral vectors for gene therapy. Major targets for this therapy include cancer, HIV, arthritis, cardiovascular and CNS diseases and cystic fibrosis. Animal cells are used as in vitro substrates in pharmacological and toxicological studies. This book is designed to serve as a comprehensive review of animal cell culture, covering the current status of both research and applications. For the student or R&D scientist or new researcher the protocols are central to the performance of cell culture work, yet a broad understanding is essential for translation of laboratory findings into the industrial production. Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field to produce state-of-the-art collection of current research. A major reference volume on cell culture research and how it impacts on production of biopharmaceutical proteins worldwide, the book is essential reading for everyone working in cell culture and is a℗ℓrecommended volume for all biotechnology libraries.
Medical Library (Lane)
Book
online resource (xiii, 256 pages) : illustrations (some color) ; 26 cm
  • 1. Unilateral common carotid artery ligation as a model of perinatal asphyxia: the original Rice-Vannucci model
  • 2. Bilateral uterine artery ligation (BUAL): placental insufficiency causing fetal growth restriction and cerebral palsy
  • 3. Perinatal intracerebral hemorrhage model and developmental disability
  • 4. Preterm rabbit model of glycerol-induced intraventricular hemorrhage
  • 5. Models of perinatal brain injury in premature and term newborns resulting from gestational inflammation due to inactivated group B streptococcus (GBS), or lipopolysaccharide (LPS) from E. coli and/or immediately postnatal hypoxia-ischemia (HI)
  • 6. Fetal brain activity in the sheep model with intrauterine hypoxia
  • 7. Studies of perinatal asphyxial brain injury in the fetal sheep
  • 8, The sheep as a model of brain injury in the premature infant
  • 9. The rabbit as a model of cerebral palsy
  • 10. A newborn piglet survival model of post-hemorrhagic ventricular dilatation (PHVD)
  • 11. Physiologic aspects of the piglet as a model of neonatal hypoxia and reoxygenation
  • 12. The newborn pig global hypoxic-ischemic model of preinatal brain and organ injury
  • 13. Animal models of fetal alcohol spectrum disorder
  • 14. Modeling intellectual disability in drosophila
  • 15. Animal models of cerebral dysgenesis: excitotoxic brain injury
  • 16. The effect of age on brain plasticity in animal models of developmental disability
  • Index.
Medical Library (Lane)
Book
online resource (xxv, 419 pages) : illustrations (some color) ; 24 cm
  • Chapter 1. Introduction : macromolecules and chimera
  • chapter 2. Accessing and displaying molecular data with chimera
  • chapter 3. Algorithms dealing with distance
  • chapter 4. Algorithms dealing with angles
  • chapter 5. Structure overlap and alignment
  • chapter 6. Potential energy functions
  • chaper 7. Rotamers and side-chain conformation
  • chapter 8. Residue networks.
Medical Library (Lane)
Book
xi, 385 pages : illustrations (some color) ; 25 cm
  • Section I: Introductory Materials
  • Regulatory actions of glucocorticoid hormones: from organisms to mechanisms.- Molecular Biology of Glucocorticoid Signaling.-Mechanisms of Glucocorticoid-regulated Gene Transcription
  • Clinical Perspective: What do Addison and Cushing tell us about Glucocorticoid Action?
  • Section II: Effects of Glucocorticoids in Metabolism
  • Regulation of Glucose Homeostasis by Glucocorticoids
  • How do Glucocorticoids Regulate Lipid Metabolism?
  • Glucocorticoids and Skeletal Muscle
  • Section III: Specific Effects of Glucocorticoids on Tissues
  • Glucocorticoid- induced osteoporosis
  • Effects of Glucocorticoids on Immune System
  • Glucocorticoids and the brain: neural mechanisms regulating the stress response
  • Glucocorticoid Regulation of Reproduction
  • Glucocorticoids and the lung
  • Glucocorticoids and the Cardiovascular System
  • Glucocorticoids and Cancer
  • Section IV: Miscellaneous Topics
  • Animal Models of Altered Glucocorticoid Signaling
  • The Dehydrogenase Hypothesis
  • Conclusions and Future Directions.
This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.
Medical Library (Lane)