%{search_type} search results

1,993 catalog results

RSS feed for this result
xxv, 837 pages : illustrations (chiefly color) ; 29 cm
Long considered the quintessential molecular biology textbook, for decades Lewin's Genes has provided the most modern presentation to this transformative and dynamic science. Now in its twelfth edition, this classic text continues to lead with new information and cutting-edge developments, covering gene structure, sequencing, organization, and expression. Leading scientists provide revisions and updates in their respective areas of study offering readers current research and relevant information on the rapidly changing subjects in molecular biology. No other text offers a broader understanding of this exciting and vital science or does so with higher quality art and illustrations. Lewin's Genes XII continues to be the clear choice for molecular biology and genetics.
Medical Library (Lane)
vi, 421 pages : illustrations (some color) ; 24 cm
  • Modeling asymmetric cell division in Caulobacter crescentus using a boolean logic approach / Ismael Sánchez-Osorio, Carlos A. Hernández-Martínez, and Agustino Martínez-Antonio
  • Spatiotemporal models of the asymmetric division cycle of Caulobacter crescentus / Kartik Subramanian and John J. Tyson
  • Intrinsic and extrinsic determinants linking spindle pole fate, spindle polarity, and asymmetric cell division in the budding yeast S. cerevisiae / Marco Geymonat and Marisa Segal
  • Wnt signaling polarizes C. elegans asymmetric cell divisions during development / Arielle Koonyee Lam and Bryan T. Phillips
  • Asymmetric cell division in the one-cell C. elegans embryo: multiple steps to generate cell size asymmetry / Anne Pacquelet
  • Size matters: how C. elegans asymmetric divisions regulate apoptosis / Jerome Teuliere and Gian Garriga
  • The midbody and its remnant in cell polarization and asymmetric cell division / Christian Pohl
  • Drosophila melanogaster neuroblasts: a model for asymmetric stem cell divisions / Emmanuel Gallaud, Tri Pham, and Clemens Cabernard
  • Asymmetric divisions in oogenesis / Szczepan M. Bilinski, Jacek Z. Kubiak, and Malgorzata Kloc
  • Asymmetric localization and distribution of factors determining cell fate during early development of Xenopus laevis / Radek Sindelka, Monika Sidova, Pavel Abaffy, and Mikael Kubista
  • Asymmetries in cell division, cell size, and furrowing in the Xenopus laevis embryo / Jean-Pierre Tassan, Martin Wühr, Guillaume Hatte, and Jacek Kubiak
  • Asymmetric and unequal cell divisions in ascidian embryos / Takefumi Negishi and Hiroki Nishida
  • Asymmetries and symmetries in the mouse oocyte and zygote / Agathe Chaigne, Marie-Emilie Terret, and Marie-Hélène Verlhac
  • Symmetry does not come for free: cellular mechanisms to achieve a symmetric cell division / Damian Dudka and Patrick Meraldi
  • A comparative perspective on Wnt/[beta]-catenin signalling in cell fate determination / Clare L. Garcin and Shukry J. Habib
  • Extracellular regulation of the mitotic spindle and fate determinants driving asymmetric cell division / Prestina Smith, Mark Azzam, and Lindsay Hinck
  • Regulation of asymmetric cell division in mammalian neural stem and cancer precursor cells / Mathieu Daynac and Claudia K. Petritsch
  • Molecular programs underlying asymmetric stem cell division and their disruption in malignancy / Subhas Mukherjee and Daniel J. Brat.
Medical Library (Lane)
xi, 372 pages : illustrations ; 24 cm
  • Drosophila Malpighian tubules: a model for understanding kidney development, function, and disease / Naveen Kumar Gautam, Puja Verma, and Madhu G. Tapadia
  • Zebrafish pronephros development / Richard W. Naylor, Sarah S. Qubisi, and Alan J. Davidson
  • Zebrafish as a model of kidney disease / Elvin E. Morales and Rebecca A. Wingert
  • Use of Xenopus frogs to study renal development/repair / Shoshoni T. Droz and Kelly A. McLaughlin
  • Tissue-specific functions of p53 during kidney development / Zubaida Saifudeen
  • Growth factor regulation in the nephrogenic zone of the developing kidney / Leif Oxburgh, Sree Deepthi Muthukrishnan, and Aaron Brown
  • Development and diseases of the collecting duct system / Lihe Chen, Paul J. Higgins, and Wenzheng Zhang
  • Origin and function of the renal stroma in health and disease / Christopher J. Rowan, Sepideh Sheybani-Deloui, and Norman D. Rosenblum
  • Imaging, analysing and interpreting branching morphogenesis in the developing kidney / Kieran M. Short and Ian M. Smyth
  • Genetic syndromes affecting kidney development / Abhijeet Pal and Kimberly J. Reidy
  • Primary cilia in cystic kidney disease / Prachee Avasthi, Robin L. Maser, and Pamela V. Tran
  • Inflammation and fibrosis in polycystic kidney disease / Cheng Jack Song, Kurt A. Zimmerman, Scott J. Henke, and Bradley K. Yoder
  • Epithelial to mesenchymal transition (EMT) and endothelial to mesenchymal transition (EndMT): role and implications in kidney fibrosis / Ana S. Cruz-Solbes and Keith Youker.
Medical Library (Lane)
x, 376 pages : illustrations (chiefly color) ; 25 cm
  • Evolutionary Aspects of Macrophages Polarization / Eva-Stina Edholm, Kun Hyoe Rhoo, and Jacques Robert
  • Development and Functional Differentiation of Tissue-Resident Versus Monocyte-Derived Macrophages in Inflammatory Reactions Paola Italiani and Diana Boraschi
  • Hofbauer Cells: Placental Macrophages of Fetal Origin / Leticia Reyes, Bryce Wolfe, and Thaddeus Golos
  • Mesenchymal Stem Cells Direct the Immunological Fate of Macrophages / Patricia Luz-Crawford, Christian Jorgensen, and Farida Djouad
  • Monocyte/Macrophage: NK Cell Cooperation--Old Tools for New Functions / Elżbieta Wałajtys-Rode and Jolanta M. Dzik
  • Macrophages in Invertebrates: From Insects and Crustaceans to Marine Bivalves / Prasad Abnave, Xavier Muracciole, and Eric Ghigo
  • F4/80 as a Major Macrophage Marker: The Case of the Peritoneum and Spleen / Alexandra dos Anjos Cassado
  • Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase / Martin Lee [and others]
  • Role for Mechanotransduction in Macrophage and Dendritic Cell Immunobiology / Svenja F. B. Mennens, Koen van den Dries, and Alessandra Cambi
  • Macrophages' Role in Tissue Disease and Regeneration / Lewis Gaffney [and others]
  • Macrophages and Their Contribution to the Development of Atherosclerosis / Yuri V. Bobryshev [and others]
  • Macrophage Dysfunction in Respiratory Disease / Kylie B. R. Belchamber and Louise E. Donnelly
  • Activation of Macrophages in Response to Biomaterials / Jamie E. Rayahin and Richard A. Gemeinhart
  • Macrophage Differentiation in Normal and Accelerated Wound Healing / Girish J. Kotwal and Sufan Chien
  • Macrophages and RhoA Pathway in Transplanted Organs / Yianzhu Liu [and others].
Medical Library (Lane)
xi, 510 pages : color illustrations ; 25 cm
  • 1. Exoogenous molecule and organelle delivery in oogenesis
  • 2. Control of mammalian oocyte development by interactions with the matenal follicular environment
  • 3. Transovarial transmission of symbionts in insects
  • 4. Acquisition of oocyte polarity
  • 5. The pole (germ) plasm in insect oocytes
  • 6. Multiple functions of the DEAD-Box helicase vasa in Drosophila oogenesis
  • 7. The role of microtubule motors in mRNA localization and patterning within the Drosophila oocyte
  • 8. Phosphoinositides and cell polarity in the Drosophila egg chamber
  • 9. RNA localization in the vertebrate oocyte: establishment of oocyte polarity and localized mRNA assemblages
  • 10. DNA methyltransferases in mammalian oocytes
  • 11. Accumulation of chromatin remodelling enzyme and histone transcripts in bovine oocytes
  • 12. Translational regulation in the mammalian oocyte
  • 13. Regulation of translationally repressed mRNAs in zebrafish and mouse oocytes
  • 14. Switches in dicer activity during oogenesis and early development
  • 15. The regulation and function of cohesin and condensin in mammalian oocytes and spermatocytes
  • 16. Supply and demand of energy in the oocyte and the role of mitochondria
  • 17. Functions of vitellogenin in eggs
  • 18. Lipids in insect oocytes: from the storage pathways to their multiple functions
  • 19. Parthenogenesis in insects: the centriole renaissance
  • 20. The origin and evolution of maternal genes
  • 21. Noninheritable maternal factors useful for genetic manipulation in mammals.
Medical Library (Lane)
x, 292 pages : illustrations (some color) ; 25 cm
Medical Library (Lane)
x, 309 pages : color illustrations ; 25 cm
  • 1 Introduction: How we encountered TCTP and our purpose in studying it
  • 2 Structural insights into TCTP and its interactions with ligands and proteins
  • 3 Structure-Function relationship of TCTP
  • 4 The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation
  • 5 Current understanding of the TCTP interactome
  • 6 Role and fate of TCTP in protein degradative pathways
  • 7 Roles of the Translationally Controlled Tumor Protein (TCTP) in plant development
  • 8 Function of Translationally controlled tumor protein in organ growth: Lessons from Drosophila studies
  • 9 Translationally controlled tumor protein (TCTP/HRF) present in animal venoms
  • 10 Tctp in Neuronal Circuitry Assembly
  • 11 Elusive role of TCTP protein and mRNA in cell cycle and cytoskeleton regulation
  • 12 TCTP protein and the cellular response to ionizing radiation-induced DNA damage
  • 13 TCTP has a crucial role in the different stages of Prostate Cancer malignant progression
  • 14 Role of TCTP for cellular differentiation and cancer therapy
  • 15 Targeting TCTP with sertraline and thioridazine in cancer treatment
  • 16 . History of Histamine Releasing Factor (HRF)/TCTP including a Potential Therapeutic Target in Asthma and Allergy.
This book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development. It begins by discussing the structure/function of TCTP, before exploring its role in different species ranging from plants to Drosophila and covering fields such as development, the cytoskeleton, cell division, DNA fragility and apoptosis. In turn, the book's final section is devoted to the role of TCTP in disease, namely asthma and diverse cancers, and ultimately as a target for the treatment of malignancies. What is the common denominator between all these processes and why is TCTP necessary in order for them to occur, even in the worst case such as cancer? The book seeks to provide meaningful answers to this and other key questions. Presenting a broad and revealing view on the topic, it offers an informative guide for scientists and students alike.
Medical Library (Lane)
xxiii, 810 pages, 100 variously numbered pages : color illustrations, charts ; 29 cm
  • Part I. Patterns and processes of becoming: a framework for understanding animal development
  • 1. Making new bodies: mechanisms of developmental organization
  • 2. Specifying identity: mechanisms of developmental patterning
  • 3. Differential gene expression: mechanisms of cell differentiation
  • 4. Cell-to-cell communication: mechanisms of morphogenesis
  • 5. Stems cells: their potential and their niches
  • Part II. Gametogenesis and fertilization: the circle of sex
  • 6. Sex determination and gametogenesis
  • 7. Fertilization: beginning a new organism
  • Part III. Early development: cleavage, gastrulation, and axis formation
  • 8. Rapid specification in snails and nematodes
  • 9. The genetics of axis specification in Drosophila
  • 10. Sea urchins and tunicates: deuterostome invertebrates
  • 11. Amphibians and fish
  • 12. Birds and mammals
  • Part IV. Building with ectoderm: the vertebrate nervous system and epidermis
  • 13. Neural tube formation and patterning
  • 14. Brain growth
  • 15. Neural crest cells and axonal specificity
  • 16. Ectodermal placodes and the epidermis
  • Part V. Building with mesoderm and endoderm: organogenesis
  • 17. Paraxial mesoderm: the somites and their derivatives
  • 18. Intermediate and lateral plate mesoderm: heart, blood, and kidneys
  • 19. Development of the tetrapod limb
  • 20. The endoderm: tubes and organs for digestion and respiration
  • Part IV. Postembryonic development
  • 21. Metamorphosis: the hormonal reactivation of development
  • 22. Regeneration
  • 23. Aging and senescence
  • Part VII. Development in wider contexts
  • 24. Development in health and disease: birth defects, endocrine disruptors, and cancer
  • 25. Development and the environment: biotic, abiotic, and symbiotic regulation of development
  • 26. Development and evolution: developmental mechanisms of evolutionary change.
Medical Library (Lane)
xix, 927 pages : illustrations ; 26 cm
Medical Library (Lane)
xl, 1170, G-28, I-36 pages : color illustrations, portraits ; 29 cm
  • Pt. I, Chemical and molecular foundations :
  • Molecules, cells, and model organisms
  • Chemical foundations
  • Protein structure and function
  • Culturing and visualizing cells.
  • Pt. II, Biomembranes, genes, and gene regulation :
  • Fundamental molecular genetic mechanisms
  • Molecular genetic techniques
  • Biomembrane structure
  • Genes, genomics, and chromosomes
  • Transcriptional control of gene expression
  • Post-transcriptional gene control.
  • Pt. III, Cellular organization and function :
  • Transmembrane transport of ions and small molecules
  • Cellular energetics
  • Moving proteins into membranes and organelles
  • Vesicular traffic, secretion, and endocytosis
  • Signal transduction and G protein, coupled receptors
  • Signaling pathways that control gene expression
  • Cell organization and movement I: microfilaments
  • Cell organization and movement II: microtubules and intermediate filaments
  • The Eukaryotic cell cycle.
  • Pt. IV, Cell growth and differentiation :
  • Integrating cells into tissue
  • Stem cells, cell asymmetry, and cell death
  • Cells of the nervous system
  • Immunology
  • Cancer.
Medical Library (Lane)
xxxiv, 1342, 34, 53, 1 pages : illustrations (chiefly color) ; 29 cm
  • Cells and genomes
  • Cell chemistry and bioenergetics
  • Proteins
  • DNA, chromosomes, and genomes
  • DNA replication, repair, and recombination
  • How cells read the genome: from DNA to protein
  • Control of gene expression
  • Analyzing cells, molecules, and systems
  • Visualizing cells
  • Membrane structure
  • Membrane transport of small molecules and the electrical properties of membranes
  • Intracellular compartments and protein sorting
  • Intracellular membrane traffic
  • Energy conversion: mitochondria and chloroplasts
  • Cell signaling
  • The cytoskeleton
  • The cell cycle
  • Cell death
  • Cell junctions and the extracellular matrix
  • Cancer
  • Development of multicellular organisms
  • Stem cells and tissue renewal
  • Pathogens and infection
  • The innate and adaptive immune systems.
"As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts. As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced. Protein structures better illustrate structure-function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing open-ended questions highlighting "What We Don't Know, " introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text. Thought-provoking end-of-chapter questions have been expanded to all chapters, including questions on developmental biology, tissues and stem cells, the immune system, and pathogens."-- Provided by publisher.
Medical Library (Lane)
xxxvi, 406 pages : illustrations ; 24 cm
  • Growing up in Brooklyn
  • The essential Paul Berg
  • College and World War II
  • Western Reserve University
  • Copenhagen
  • Washington University, St. Louis
  • Discovering transfer RNA
  • Stanford University and its refurbished Department of Biochemistry
  • Transcription and translation : new directions
  • Making recombinant DNA : the first faltering steps
  • Making recombinant DNA : a major breakthrough
  • EcoRI restriction endonuclease : a major breakthrough
  • "Coincidence is the word we use when we can't see the levers and pulleys"
  • Yet another Stanford contribution
  • An historic meeting in Hawaii
  • The recombinant DNA controversy
  • A momentous Gordon Research Conference
  • Making recombinant molecules with frog DNA
  • The controversy heats up
  • Asilomar II
  • The dissenters : a different point of view
  • The aftermath
  • Legislative and revisionist challenges to recombinant DNA
  • Asilomar II : lessons learned
  • The Nobel Prize in chemistry
  • Commercializing the technology
  • Life goes on
  • The "retirement" years
  • Public policy issues : and other interests
  • Personal challenges.
Medical Library (Lane)
online resource (xxx, 928 pages) : illustrations ; 28 cm
The first book on the clinical application of genetics in primary care medicine, Clinical Genomics focuses on the everyday application of genetic assessment and its diagnostic, therapeutic, and preventive implications in clinical practice. Unlike traditional textbooks on medical genetics and dysmorphology, this is a clinical reference that covers many of the common diseases seen in everyday medical practice. Features: endorsed by the American College of Physicians; addresses the genetic basis of common chronic diseases, not just the classic diseases of dysmorphology.
Medical Library (Lane)
ix, 290 pages : illustrations (some color) ; 24 cm
  • Extracellular Matrix Evolution: An Overview / Josephine C. Adams
  • Domain Shuffling and the Evolution of Vertebrate Extracellular Matrix / Hiroshi Wada
  • Invertebrate and Vertebrate Collagens / Jean-Yves Exposito, Claire Lethias
  • The Evolution of Elastin / Fred W. Keeley
  • Evolutionary Insights into Fibrillin Structure and Function in the Extracellular Matrix / Sacha Jensen, David Yadin, Ian Robertson
  • Molecular Evolution of the Microfibril-Associated Proteins: The Fibulins and the MAGPs / Fernando Segade
  • Evolution and Function of SPARC and Tenascins: Matricellular Counter-Adhesive Glycoproteins with Pleiotropic Effects on Angiogenesis and Tissue Fibrosis / Cristina A. Baratta, Theodore J. Brown
  • Thrombospondins and Their Receptors: Evolving Functions / David D. Roberts, William A. Frazier
  • Evolution of Cell Adhesion to Extracellular Matrix / Mark S. Johnson, Jarmo Käpylä, Konstantin Denessiouk.
The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
Medical Library (Lane)
x, 253 pages : illustrations (some color) ; 24 cm
  • Part I. Informational Signals in Extracellular Matrix and Matrix Influences on Cell Movement in the Developing Embryo. The Glycocode: Translating Heparan Sulfate Fine Structure into Developmental Function / Adam B. Cadwallader, H. Joseph Yost
  • Extracellular Matrix Dynamics in Early Development / Andras Czirok, Brenda J. Rongish, Charles D. Little
  • Extracellular Matrix Functions in Amphibian Gastrulation / Bette J. Dzamba, Douglas W. DeSimone
  • Part II. Extracellular Matrix-Direct Morphogenesis, Growth Factor Signaling, and Maintenance of the Stem Cell Niche. Cell-ECM Interactions and the Regulation of Epithelial Branching Morphogenesis / William P. Daley, Kenneth M. Yamada
  • Interactions Between Neural Crest-Derived Cells and Extracellular Microenvironment During Cardiovascular Development / Sophie Astrof
  • Engineered ECM Microenvironments and Their Regulation of Stem Cells / Yu Suk Choi, Andrew W. Holle, Adam J. Engler
  • Part III. Model Organisms and the Lexicon of Developmental Signals Associated with the Extracellular Matrix. ECM in Hydra Development and Regeneration / Xiaoming Zhang, Michael P. Sarras Jr
  • Extracellular Matrix Remodeling in Zebrafish Development / Nathan A. Mundell, Jason R. Jessen
  • The Role of HA and Has2 in the Development and Function of the Skeleton / Peter J. Roughley, Pierre Moffatt.
Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix - secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
Medical Library (Lane)
xxxiii, 1154, [58] pages : color illustrations, portraits ; 28 cm
  • Preface
  • Part 1: Chemical And Molecular Foundations:
  • Molecules, cells, and evolution:
  • Molecules of life
  • Genomes, cell architecture, and cell function
  • Cells into tissues: unicellular and metazoan organisms used for molecular cell biology investigations
  • Chemical foundations:
  • Covalent bonds and noncovalent interactions
  • Chemical building blocks of cells
  • Chemical reactions and chemical equilibrium
  • Biochemical energetics
  • Protein structure and function:
  • Hierarchical structure of proteins
  • Protein folding
  • Protein binding and enzyme catalysis
  • Regulating protein function
  • Purifying, detecting, and characterizing proteins
  • Proteomics
  • Part 2: Genetics And Molecular Biology:
  • Basic molecular genetic mechanism:
  • Structure of nucleic acids
  • Nucleic acid strand is a linear polymer with end-to-end directionality
  • Transcription of protein-coding genes and formation of functional mRNA
  • Decoding of mRNA by tRNA
  • Stepwise synthesis of proteins on ribosomes
  • DNA replication
  • DNA repair and recombination
  • Viruses: parasites of the cellular genetic system
  • Molecular genetic techniques:
  • Genetic analysis of mutations to identify and study genes
  • DNA cloning and characterization
  • Using cloned DNA fragments to study gene expression
  • Locating and identifying human disease genes
  • Inactivating the function of specific genes in eukaryotes
  • Genes, genomics, and chromosomes:
  • Eukaryotic gene structure
  • Chromosomal organization of genes and noncoding DNA
  • Transposable (mobile) DNA elements
  • Organelle DNAs
  • Genomics: genome-wide analysis of gene structure and expression
  • Structural organization of eukaryotic chromosomes
  • Morphology and functional elements of eukaryotic chromosomes
  • Transcriptional control of gene expression:
  • Control of gene expression in bacteria
  • Overview of eukaryotic gene control
  • RNA polymerase 2 promoters and general transcription factors
  • Regulatory sequences in protein-coding genes and the proteins through which they function
  • Molecular mechanisms of transcription repression and activation
  • Regulation of transcription-factor activity
  • Epigenetic regulation of transcription
  • Other eukaryotic transcription systems
  • Post-transcriptional gen control:
  • Processing of eukaryotic pre-mRNA
  • Regulation of pre-mRNA processing
  • Transport of mRNA across the nuclear envelope
  • Cytoplasmic mechanism of post-transcriptional control
  • Processing of rRNA and tRNA
  • Part 3: Cell Structure And Function:
  • Culturing, visualizing, and perturbing cells:
  • Growing cells in culture
  • Light microscopy: exploring cell structure and visualizing proteins within cells
  • Electron microscopy: high-resolution imaging
  • Isolation and characterization of cell organelles
  • Perturbing specific cell functions
  • Biomembrane structure:
  • Lipid bilayer: composition and structural organization
  • Membrane proteins: structure and basic functions
  • Phospholipids, Sphingolipids, and cholesterol: synthesis and intracellular movement
  • Transmembrane transport of ions and small molecules:
  • Overview of transmembrane transport
  • Facilitated transport of glucose and water
  • ATP-powered pumps and the intracellular ionic environment
  • Nongated ion channels and the resting membrane potential
  • Cotransport by symporters and antiporters
  • Transcellular transport
  • Cellular energetics:
  • First step of harvesting energy from glucose: glycolysis
  • Mitochondria and the citric acid cycle
  • Electron transport chain and generation of the proton-motive force
  • Harnessing the proton-motive force to synthesize ATP
  • Photosynthesis and light-absorbing pigments
  • Molecular analysis of photosystems
  • CO2 metabolism during photosynthesis
  • Moving proteins into membranes and organelles:
  • Targeting proteins to and across the ER membrane
  • Insertion of membrane proteins into the ER
  • Protein modifications, folding, and quality control in the ER
  • Targeting of proteins to mitochondria and chloroplasts
  • Targeting of peroxisomal proteins
  • Transport into and out of the nucleus
  • Vesicular traffic, secretion, and endocytosis:
  • Techniques for studying the secretory pathway
  • Molecular mechanisms of vesicle budding and fusion
  • Early stages of the secretory pathway
  • Later stages of the secretory pathway
  • Receptor-mediated endocytosis
  • Directing membrane proteins and cytosolic materials to the lysosome
  • Signal transduction and G protein-coupled receptors:
  • Signal transduction: from extracellular signal to cellular response
  • Studying cell surface receptors and signal transduction proteins
  • G protein-coupled receptors: structure and mechanism
  • G protein-coupled receptors that regulated ion channels
  • G protein-coupled receptors that activate or inhibit adenylyl cyclase
  • G protein-coupled receptors that trigger elevations in cytosolic Ca2+
  • Signaling pathways that control gene expression:
  • Receptors that activate protein tyrosine kinases
  • Ras/MAP kinase pathway
  • Phosphoinositide signaling pathways
  • Receptor serine kinases that activate smads
  • Signaling pathways controlled by Ubiquitination: Wnt, Hedgehog, and NF-kb
  • Signaling pathways controlled by protein cleavage: notch/delta, SREBP
  • Integration of cellular responses to multiple signaling pathways
  • Cell organization and movement 1: microfilaments:
  • Microfilaments and actin structures
  • Dynamics of actin filaments
  • Mechanisms of actin filament assembly
  • Organization of actin-based cellular structures
  • Myosins: actin-based motor proteins
  • Myosin-powered movements
  • Cell migration: mechanism, signaling, and chemotaxis
  • Cell organization and movement 2: Microtubules and intermediate filaments:
  • Microtubule structure and organization
  • Microtubule dynamics
  • Regulation of microtubule structure and dynamics
  • Kinesins and dyneins: microtubule-based motor proteins
  • Cilia and flagella: microtubule-based surface structures
  • Mitosis
  • Intermediate filaments
  • Coordination and cooperation between cytoskeletal elements
  • Eukaryotic cell cycle:
  • Overview of the cell cycle and its control
  • Model organisms and methods to study the cell cycle
  • Regulation of CDK activity
  • Commitment to the cell cycle and DNA replication
  • Entry into mitosis
  • Completion of mitosis: chromosome segregation and exit from mitosis
  • Surveillance mechanisms in cell cycle regulation
  • Meiosis: a special type of cell division
  • Part 4: Cell Growth And Development:
  • Integrating cells into tissues:
  • Cell-cell and cell-matrix adhesion: an overview
  • Cell-cell and cell-ECM junctions and their adhesion molecules
  • Extracellular matrix 1: basal lamina
  • Extracellular matrix 2: connective tissue
  • Adhesive interactions in motile and nonmotile cells
  • Plant tissues
  • Stem cells, cell asymmetry, and cell death
  • Early metazoan development and embryonic stem cells
  • Stem cells and niches in multicellular organisms
  • Mechanisms of cell polarity and asymmetric cell division
  • -- Cell death and its regulation
  • Nerve cells:
  • Neurons and glia: building blocks of the nervous system
  • Voltage-gated ion channels and the propagation of action potentials
  • Communication at synapses
  • Sensing the environment: touch, pain, taste, and smell
  • Immunology:
  • Overview of host defenses
  • Immunoglobulins: structure and function
  • Generation of antibody diversity and B-cell development
  • MHC and antigen presentation
  • T cells, T-cell receptors, and T-cell development
  • Collaboration of immune-systems cells in the adaptive response
  • Cancer:
  • Tumor cells and the onset of cancer
  • Genetic basis of cancer
  • Cancer and misregulation of growth regulatory pathways
  • Cancer and mutation of cell division and checkpoint regulators
  • Carinogens and caretaker genes in cancer
  • Glossary
  • Index.
Overview: Molecular Cell Biology presents the key concepts in cell biology and their experimental underpinnings. The authors, all world-class researchers and teachers, incorporate medically relevant examples where appropriate to help illustrate the connections between cell biology and health and human disease. As always, a hallmark of MCB is the use of experiments to engage students in the history of cell biology and the research that has contributed to the field. The book contains predominantly color illustrations, with some black-and-white illustrations.
Medical Library (Lane)
xxii, 1008 pages : color illustrations ; 28 cm
  • Biological molecules
  • Energy and entropy
  • Free energy
  • Molecular interactions
  • Kinetics and catalysis.
"Key to making future advances in the areas of biochemistry and molecular medicine is a new generation of molecular biologists and biochemists who are able to harness the tools and insights of physics and chemistry to exploit the emergence of genomic and systems-level information in biology.The basic ideas of energy, entropy, equilibrium thermodynamics, transport processes and reaction kinetics are closely related to exciting issues in contemporary biology, such as protein folding, chaperones and prion diseases, DNA polymerase and ribosome fidelity, DNA recognition, drug design, signal transduction, ion channel function, motor protein action and the versatility of enzyme mechanism." ... "Molecules of Life" ... deepens our understanding of how life functions by illuminating the physical principles underpinning biological phenomena." --Excerpts from publisher notes.
Medical Library (Lane)
xxiii, 832 pages : illustrations (chiefly color), color map ; 29 cm
  • 1. The Genetics Revolution in the Life Sciences
  • 2. Single-Gene Inheritance
  • 3. Independent Assortment of Genes
  • 4. Mapping Eukaryote Chromosomes by Recombination
  • 5. The Genetics of Bacteria and Their Viruses
  • 6. Gene Interaction
  • 7. DNA: Structure and Replication
  • 8. RNA: Transcription and Processing
  • 9. Proteins and Their Synthesis
  • 10. Gene Isolation and Manipulation
  • 11. Regulation of Gene Expression in Bacteria and Their Viruses
  • 12. Regulation of Gene Expression in Eukaryotes
  • 13. The Genetic Control of Development
  • 14. Genomes and Genomics
  • 15. The Dynamic Genome: Transposable Elements
  • 16. Mutation, Repair, and Recombination
  • 17. Large-Scale Chromosomal Changes
  • 18. Population Genetics
  • 19. The Inheritance of Complex Traits
  • 20. Evolution of Genes and Traits.
Medical Library (Lane)
xi, 390 pages : illustrations (some color) ; 24 cm
  • Introduction: Reminiscing on Models and Modeling / Robert B. Denman
  • Probing Astrocyte Function in Fragile X Syndrome / Shelley Jacobs, Connie Cheng and Laurie C. Doering
  • Neural Stem Cells / Maija Castrén
  • Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System / Theodore J. Price and Ohannes K. Melemedjian
  • The Role of the Postsynaptic Density in the Pathology of the Fragile X Syndrome / Stefan Kindler and Hans-Jürgen Kreienkamp
  • Behavior in a Drosophila Model of Fragile X / Sean M. McBride, Aaron J. Bell and Thomas A. Jongens
  • Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome / Charles R. Tessier and Kendal Broadie
  • Fragile X Mental Retardation Protein and Stem Cells / Abrar Qurashi, Xuekun Li and Peng Jin
  • Manipulating the Fragile X Mental Retardation Proteins in the Frog / Marc-Etienne Huot, Nicolas Bisson, Thomas Moss and Edouard W. Khandjian
  • Exploring the Zebra Finch Taeniopygia guttata as a Novel Animal Model for the Speech-Language Deficit of Fragile X Syndrome / Claudia Winograd and Stephanie Ceman
  • Neuroendocrine Alterations in the Fragile X Mouse / Abdeslem El Idrissi, Xin Yan, William L'Amoreaux, W. Ted Brown and Carl Dobkin
  • Taking STEPs Forward to Understand Fragile X Syndrome / Susan M. Goebel-Goody and Paul J. Lombroso
  • Fmr-1 as an Offspring Genetic and a Maternal Environmental Factor in Neurodevelopmental Disease / Bojana Zupan and Miklos Toth
  • Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome / Michael R. Hunsaker, Gloria Arque, Robert F. Berman, Rob Willemsen and Renate K. Hukema
  • Clinical Aspects of the Fragile X Syndrome / W. Ted Brown
  • Fragile X Syndrome: A Psychiatric Perspective / Michael R. Tranfaglia
  • Fragile X Syndrome and Targeted Treatment Trials / Randi Hagerman, Julie Lauterborn, Jacky Au and Elizabeth Berry-Kravis
  • The Fragile X-Associated Tremor Ataxia Syndrome / Flora Tassone and Randi Hagerman
  • Vignettes: Models in Absentia / Robert B. Denman.
Medical Library (Lane)
ix, 284 pages : illustrations ; 25 cm
  • From bioplastics to H. sapiens 2.0
  • -3,800 Myr, Late Hadean : at the inorganic/organic interface
  • -3,500 Myr, Archean : reading the most ancient texts and the future of living software
  • -500 Myr, Cambrian : the mirror world and the explosion of diversity ; How fast can evolution go and how diverse can it be?
  • -360 Myr, Carboniferous : "the best substitute for petroleum is petroleum"
  • -60 Myr, Paleocene : emergence of mammalian immune system ; Solving the health care crisis through genome engineering
  • -30,000 Yr, Pleistocene Park : engineering extinct genomes
  • -10,000 Yr, Neolithic : industrial revolutions ; The agricultural revolution and synthetic genomics ; The BioFab Manifesto
  • -100 Yr, Anthropocene : the third industrial revolution ; iGEM
  • -1 Yr, Holocene : from personal genomes to immortal human components
  • Epigenetic epilogue. +1 Yr, the end of the beginning, transhumanism, and the Panspermia Era : societal risks and countermeasures.
Medical Library (Lane)