Book — 1 online resource (xii, 182 pages) : illustrations.
Permanence of the synapse and molecular instability.- Cellular biology of AMPA receptor trafficking and synaptic plasticity.- Imaging of experience-dependent structural plasticity in the mouse neocortex in vivo.- Synapse loss, synaptic plasticity and the postsynaptic density.- Impact of Beta Amyloid on Excitatory Synaptic Transmission and Plasticity.- Quantitative neuropathology in Alzheimer's mouse models.- Multiple levels of synaptic regulation by NMDA-type glutamate receptor in normal and disease states.- Soluble Oligomers of the Amyloid ss-Protein Impair Synaptic Plasticity and Behavior.- Why Alzheimer's is a disease of memory: synaptic targeting by pathogenic Ass oligomers (ADDLs).- Synaptic transmission dynamically modulates interstitial fluid amyloid-b levels.- Ass-induced toxicity mediated by caspase cleavage of the amyloid precursor protein (APP).- Long-term potentiation and Ass: targeting Ass species, cellular mechanisms and putative receptors.- Genes, synapses and autism spectrum disorders.- Subject Index.
(source: Nielsen Book Data)
"Remarkable progress has been made in Alzheimer's research over the last decade. Our understanding of which molecular mechanisms are involved in the cascade of events characteristic of the disease is growing. However, the mechanisms by which they induce deleterious effect are still not clear. Many recent studies have confirmed that the synapse is a key target in the pathogenesis of Alzheimer's disease. Not only does synaptic loss occur at an early stage of the disease, but it seems that [Beta]-amyloid peptide deposits or microtubular disorders affect synaptic function. This may explain the memory deficits that are so characteristic of the disease. It is therefore logical to investigate therapeutic approaches targeting the deleterious mechanisms that affect the synapse. This area of research promises to be all the more productive because synaptic dysfunction is involved in various other neurodegenerative diseases or, more generally speaking, central nervous system disorders."--Jacket.