• Burden, cost, and epidemiology of acute rheumatic fever and rheumatic heart disease
• Pathogenesis of acute rheumatic fever
• Clinical evaluation and diagnosis of acute rheumatic fever
• Management of acute rheumatic fever
• Clinical evaluation and diagnosis of rheumatic heart disease
• Medical management of rheumatic heart disease
• Catheter-based investigation and treatment of rheumatic heart disease
• Surgical management of rheumatic heart disease
• Rheumatic heart disease in pregnancy
• Primordial and primary prevention prevention of ARF and RHD
• Secondary prevention of ARF and RHD
• Control programmes, registries, and access to care
• Rheumatic heart disease screening
• Group A streptococcal vaccine
• Advocacy and education
• Acute complications and Emergencies of ARF and RHD.

Acute Rheumatic Fever and Rheumatic Heart Disease is a concise, yet comprehensive, clinical resource highlighting must-know information on rheumatic heart disease and acute rheumatic fever from a global perspective. Covering the major issues dominating the field, this practical resource presents sufficient detail for a deep and thorough understanding of the latest treatment options, potential complications, and disease management strategies to improve patient outcomes. Divided into four distinct sections for ease of navigation: Acute Rheumatic Fever, Rheumatic Heart Disease, Population-Based Strategies for Disease Control, and Acute and Emergency Presentations. International editors and chapter authors ensure a truly global perspective. Covers all clinical aspects, including epidemiology, pathophysiology, clinical features, diagnosis, management, and treatment. Includes key topics on population-based measures for disease control for effective primary, secondary, and tertiary prevention. Consolidates today's available information and guidance into a single, convenient resource.

• 1. Burden, cost, and epidemiology of acute rheumatic fever and rheumatic heart disease
• 2. Pathogenesis of acute rheumatic fever
• 3. Clinical evaluation and diagnosis of acute rheumatic fever
• 4. Management of acute rheumatic fever
• 5. Clinical evaluation and diagnosis of rheumatic heart disease
• 6. Medical management of rheumatic heart disease
• 7. Catheter-based investigation and treatment of rheumatic heart disease
• 8. Surgical management of rheumatic heart disease
• 9. Rheumatic heart disease in pregnancy
• 10. Primordial and primary prevention prevention of ARF and RHD
• 11. Secondary prevention of ARF and RHD
• 12. Control programmes, registries, and access to care
• 13. Rheumatic heart disease screening
• 14. Group A streptococcal vaccine
• 15. Advocacy and education
• 16. Acute complications and Emergencies of ARF and RHD.
• (source: Nielsen Book Data)

Acute Rheumatic Fever and Rheumatic Heart Disease is a concise, yet comprehensive, clinical resource highlighting must-know information on rheumatic heart disease and acute rheumatic fever from a global perspective. Covering the major issues dominating the field, this practical resource presents sufficient detail for a deep and thorough understanding of the latest treatment options, potential complications, and disease management strategies to improve patient outcomes. Divided into four distinct sections for ease of navigation: Acute Rheumatic Fever, Rheumatic Heart Disease, Population-Based Strategies for Disease Control, and Acute and Emergency Presentations. International editors and chapter authors ensure a truly global perspective. Covers all clinical aspects, including epidemiology, pathophysiology, clinical features, diagnosis, management, and treatment. Includes key topics on population-based measures for disease control for effective primary, secondary, and tertiary prevention. Consolidates today's available information and guidance into a single, convenient resource.
(source: Nielsen Book Data)

If you're looking to make a career move from programmer to AI specialist, this is the ideal place to start. Based on Laurence Moroney's extremely successful AI courses, this introductory book provides a hands-on, code-first approach to help you build confidence while you learn key topics. You'll understand how to implement the most common scenarios in machine learning, such as computer vision, natural language processing (NLP), and sequence modeling for web, mobile, cloud, and embedded runtimes. Most books on machine learning begin with a daunting amount of advanced math. This guide is built on practical lessons that let you work directly with the code. You'll learn: How to build models with TensorFlow using skills that employers desire The basics of machine learning by working with code samples How to implement computer vision, including feature detection in images How to use NLP to tokenize and sequence words and sentences Methods for embedding models in Android and iOS How to serve models over the web and in the cloud with TensorFlow Serving

AI is poised to transform every aspect of healthcare, including the way we manage personal health from customer experience and clinical care to healthcare cost reductions. This practical book is one of the first to describe present and future use cases where AI can help solve pernicious healthcare problems. Kerrie Holley and Siupo Becker provide guidance to help informatics and healthcare leadership create AI strategy and implementation plans for healthcare. With this book, business stakeholders and practitioners will be able to build knowledge, a road map, and the confidence to support AI in their organizations-without getting into the weeds of algorithms or open source frameworks. Cowritten by an AI technologist and a medical doctor who leverages AI to solve healthcare's most difficult challenges, this book covers: The myths and realities of AI, now and in the future Human-centered AI: what it is and how to make it possible How to use various AI technologies to go beyond precision medicine Delivering patient care using the IoT and ambient computing with AI How AI can help reduce waste in healthcare AI strategy and identifying high-priority AI applications

• Cover; Title Page; Copyright Page; Brief Contents; Contents; Preface; Acknowledgments; About the Author;
• Chapter 1 The Microbial World: An Introduction; Good Morning Microbes!; 1.1 Microbiology and Society: A Connected World; 1.2 Why Microbes Matter: Protecting the Planet; The Ocean Microbiome; The Soil Microbiome; The Microbiome of the Atmosphere; The Microbiome in Earth's Crust; 1.3 Why Microbes Matter: Helping Maintain Human Health; 1.4 Why Microbes Matter: Causing Infections and Disease; 1.5 Why Microbes Matter: Benefiting Society; With Most Meals; In the Environment

• A CLOSER LOOK 1.1: Microbes to the Rescue!In the Pharmaceutical/Biotechnology Industries; 1.6 Microbiology Today: Challenges Remain; Air Travel; Urbanization and Poverty; Drug-Resistant Pathogens; Climate Change; A Final Thought; Chapter Discussion Questions;
• Chapter 2 Microbes in Perspective: The Pioneers, Classifiers, and Observers; What Shall We Call This One?; 2.1 The Roots of Microbiology: The Pioneers; Robert Hooke (1635-1703); Antony van Leeuwenhoek (1632-1723); Louis Pasteur (1822-1895); A CLOSER LOOK 2.1: Experimentation and Scientific Inquiry; Robert Koch (1843-1910)

• The Golden Age of Microbiology (1857-1917)2.2 Naming Microbes: What's in a Name?; Binomial Nomenclature; 2.3 The Microbial World: The Observers; Microbial Measurements and Cell Size; A CLOSER LOOK 2.2: "What's in a Name?"; The Light Microscope; The Electron Microscope; 2.4 Microbial Groups: Eukaryotes, Prokaryotes, and Viruses; Eukaryotic Microorganisms; Prokaryotic Organisms; The Viruses; 2.5 Taxonomy: Cataloging Life; Cataloging and Organizing Life; The Tree of Life; The Tree of Life and Society; A Final Thought; Chapter Discussion Questions

• Chapter 3 Molecules of the Cell: The Building Blocks of LifeThe Spark; 3.1 Chemistry Basics: Atoms, Bonds, and Molecules; Atoms and Bonding; Water; A CLOSER LOOK 3.1: Water and Life; The Molecules of Microbes; 3.2 Carbohydrates: Simple Sugars and Polysaccharides; Simple Sugars; Oligosaccharides and Polysaccharides; A CLOSER LOOK 3.2: How Sweet It Is; 3.3 Lipids: Fats, Phospholipids, and Sterols; Fats and Oils; Phospholipids; Sterols; 3.4 Proteins: Amino Acids and Polypeptides; Amino Acids; Polypeptides and Protein Shape; 3.5 Nucleic Acids: DNA and RNA; A Final Thought

• Chapter Discussion Questions
• Chapter 4 Exploring the Prokaryotic World: The Bacteria and Archaea Domains; Hail Caesar!; A CLOSER LOOK 4.1: Bacteria in Eight Easy Lessons1; 4.1 Cell Structure: Shapes and Arrangements; Prokaryotic Cell Shape and Arrangement; Staining Techniques; 4.2 Cell Structure: Anatomy of a Cell; Surface Structures; Surface Projections; A CLOSER LOOK 4.2: Diarrhea Doozies; Cytoplasmic Structures; 4.3 Prokaryotic Reproduction and Survival: Binary Fission and Endospores; Prokaryotic Reproduction; Measuring Prokaryotic Growth; Endospores

Most of the data that companies collect is related to customer behaviors, such as clicks on a website or purchases in a supermarket. But data science algorithms and predictive analytics tools aren't that specific, so customer data is treated the same way as, for example, astronomical or genomic data. This practical guide introduces powerful methods for behavioral data analysis that you're probably not aware of. Advanced experimental design will help you get the most out of your A/B tests, while causal diagrams will allow you to tease out causality from correlation even when you can't run experiments. Written in an accessible style for data scientists, business analysts, and behavioral scientists, this practical book provides complete examples and exercises in R and Python to help you gain more insight from your data-immediately. Understand the specifics of behavioral data Explore the differences between measurement and prediction Learn how to clean and prepare behavioral data Design and analyze experiments to drive optimal business decisions Use behavioral data to understand and measure cause and effect Segment customers in a transparent and insightful way

Micro-frontends are the answer to today's increasingly complex web applications. Inspired by the microservices model, this approach lets organizations break interfaces into separate features managed by different teams of developers. In this practical guide, Luca Mezzalira shows software architects and senior developers how to build and deliver artifacts atomically rather than use a big bang deployment structure. You'll learn how this architecture allows different teams to choose any library or framework for their micro-frontends without affecting existing components. This gives your organization technical flexibility and enables you to hire and retain a broad spectrum of talent. Micro-frontends also support distributed or colocated teams more efficiently. Pick up this book and learn how to get started with this technological breakthrough. Explore the technological impact of micro-frontends in your organization Learn how to identify, generate, and orchestrate micro-frontends Identify areas of an application UI that individual teams can handle Understand and manage the complexity that micro-frontends bring inside an organization Establish end-to-end automation for building and deploying micro-frontends using the strangler pattern

Distributed systems have become more fine-grained as organizations shift from code-heavy monolithic applications to smaller, self-contained microservices. But developing these systems brings its own set of problems. With lots of examples and practical advice, this expanded second edition takes a holistic view of the topics system architects and administrators must consider when building, managing, and evolving microservices architectures. Author Sam Newman provides you with a firm grounding in the concepts while diving into the latest solutions for modeling, integrating, testing, deploying, and monitoring your own autonomous services. Through real-world examples, you'll learn how organizations worldwide are getting the most out of these architectures. Microservices technologies are moving quickly. This book brings you up to speed. Get new information on user interfaces, container orchestration, and serverless Use microservices to align system design with your organization's goals Explore options for integrating a service with the rest of your system Take an incremental approach when splitting monolithic codebases Deploy individual microservices through continuous integration Examine the complexities of testing and monitoring distributed services Manage security with expanded content around user-to-service and service-to-service models Understand the challenges of scaling microservices architectures

"Continuing in a great tradition of publishers, editors, and authors, we proudly present to you, our readers, the twelfth edition of the "Bible of Urology"-- Campbell-Walsh-Wein Urology . Started in 1954 as Campbell's Urology and retitled Campbell-Walsh Urology in 2012, the present editors felt it was appropriate to honor Alan J. Wein, MD, PhD (Hon) for his many years of dedication to this text by adding his name to the previous chief editors. During his time as chief editor, Dr. Wein was responsible for keeping the textbook in pace with a rapidly growing field in medicine--for this diligence and dedication we are grateful. As with previous editions, the twelfth edition presents many exciting advances in our use and understanding of technology, physiology, pharmacology, epidemiology, and pathophysiology while maintaining our basic classical urological knowledge"--Preface.

• The chemistry of peels: a hypothesis of action mechanisms and a proposal of a new classification of chemical peelings
• Choosing the correct peel for the appropriate patient
• The role of priming the skin for peels
• Light chemical peels
• Medium-depth peels and trichloroacetic acid blue peel
• Trichloroacetic acid peels of the neck, chest, and arms and hands
• Phenol-croton oil peels
• Deep chemical peels
• Peels in men ; special considerations
• Combination therapy in acne : peels as adjuvant therapy
• Treatment of acne scars with a combination of chemical peels and microneedling
• The Rullan two-day croton oil-phenol chemasbrasion peel
• New advances combining the chemical reconstruction of skin scars (CROSS) and subcision
• Chemical peeling as an adjunct to facelift and eyelid surgery
• Segmental phenol croton oil peels for brow lifting, eyelid tightening, and lip eversion
• Skin resurfacing complications.

• -- Frequency
• Abnormality
• Diagnosis
• Risk: Basic Principles
• Risk: Exposure to Disease
• Risk: From Disease to Exposure
• Prognosis
• Treatment
• Prevention
• Chance
• Cause
• Summarizing the Evidence
• Knowledge Management

"This book is for clinicians-physicians, nurses, physicians' assistants, psychologists, veterinarians, and others who care for patients-who want to understand for themselves the strength of the information base for their clinical decisions"-- Provided by publisher.

• Part I: Introduction
• 1 Basic Principles of Pharmacology
• 2 Principles for Maximizing the Safety of Dermatologic Drug Therapy
• 3 Polymorphisms: Why Individual Drug Responses Vary
• 4 Adherence to Drug Therapy
• 5 Medical Decision Making Part II: Important Drug Regulatory Issues
• 6 The FDA Drug Approval Process
• 7 Pharmacovigilance: Verifying that Drugs Remain Safe
• 8 Drugs Taken Off the Market: Important Lessons Learned Part III: Systemic Drugs for Infectious Diseases
• 9 Systemic Antibacterial Agents
• 10 Systemic Antifungal Agents
• 11 Systemic Antiviral Agents
• 12 Systemic Antiparasitic Agents Part IV: Systemic Immunomodulatory Drugs
• 13 Systemic Corticosteroids
• 14 Methotrexate
• 15 Azathioprine
• 16 Mycophenolates
• 17 Cyclosporine
• 18 Phosphodiesterase-4 and Janus Kinase Inhibitors
• 19 Cytotoxic Agents
• 20 Dapsone
• 21 Antimalarial Agents
• 22 Systemic Retinoids Part V: Drugs Used in Conjunction with UV or Visible Light
• 23 Psoralen Plus Ultraviolet A Photochemotherapy and Other Phototherapy Modalities
• 24 Extracorporeal Photochemotherapy (Photopheresis)
• 25 Photodynamic Therapy Part VI: Biologic Therapeutics
• 26 Tumor Necrosis Factor Inhibitors
• 27 Interleukin 12/23 Inhibitors
• 28 Interleukin 17 Inhibitors
• 29 Interleukin 23 Inhibitors
• 30 Rituximab
• 31 Additional Biologic Therapeutics: Dupilumab, Omalizumab, Others Part VII: Miscellaneous Systemic Drugs
• 32 Antihistamines
• 33 Vasoactive and Antiplatelet Agents
• 34 Antiandrogens and Androgen Inhibitors
• 35 Psychotropic Agents
• 36 Intravenous Immunoglobulin Therapy
• 37 Systemic Anticancer Agents: Dermatologic Indications and Adverse Events
• 38 Hedgehog Pathway Inhibitors
• 39 Drugs for the Skinternist
• 40 Miscellaneous Systemic Drugs Part VIII: Topical Drugs for Infectious Diseases
• 41 Topical Antibacterial Agents
• 42 Topical Antifungal Agents
• 43 Topical and Intralesional Antiviral Agents
• 44 Topical Antiparasitic Agents Part IX: Topical Immunomodulatory Drugs
• 45 Topical Corticosteroids
• 46 Topical Retinoids
• 47 Topical and Intralesional Chemotherapeutic Agents
• 48 Topical Calcineurin Inhibitors
• 49 Topical Vitamin D3 Part X: Miscellaneous Topical Drugs
• 50 Sunscreens
• 51 Therapeutic Shampoos
• 52 ?-Hydroxy Acids
• 53 Chemical Peels
• 54 Products for the Care of Chronic Wounds
• 55 Agents Used for Treatment of Hyperkeratosis
• 56 Irritants and Allergens: When to Suspect Topical Therapeutic Agents
• 57 Miscellaneous Topical Agents Part XI: Injectable and Mucosal Routes of Drug Administration
• 58 Local Anesthetics
• 59 Injectable Dermal and Subcutaneous Fillers
• 60 Botulinum Toxin Injections
• 61 Oral Mucosal Therapeutics Part XII: Major Adverse Effects From Systemic Drugs
• 62 Hepatotoxicity of Dermatologic Drug Therapy
• 63 Hematologic Toxicity of Drug Therapy
• 64 Drug-induced Malignancy
• 65 Dermatologic Drugs During Pregnancy and Lactation
• 66 Drug Interactions
• 67 Cutaneous Drug Reactions With Systemic Features Part XIII: Special Pharmacology and Therapeutics Topics
• 68 Informed Consent and Risk Management
• 69 Compounding in Dermatology
• 70 Dermatologic Drug Therapy in Children
• Appendix I Core Questions for Understanding Systemic Dermatologic Drugs
• Appendix II The Most Potentially Serious Drug Interactions.
• (source: Nielsen Book Data)

Designed with practical usability in mind, Comprehensive Dermatologic Drug Therapy, 4th Edition, helps you safely and effectively treat the skin disorders you're likely to see in your practice. Dr. Stephen E. Wolverton and new associate editor Dr. Jashin J. Wu lead a team of global experts to bring you concise, complete guidance on today's full spectrum of topical, intralesional, and systemic drugs. You'll prescribe with confidence thanks to expert coverage of which drugs to use, when to use them, and adverse effects to monitor. Includes new drug interaction tables, drug risk profiles, and FDA guidelines, as well as two new appendices that summarize chapter questions and summarize highest-risk drug interactions. Covers the best uses for new biologic therapeutics. Contains new chapters covering medical decision-making principles, PDE-4 and JAK inhibitors, interleukin 17 inhibitors, interleukin 23 inhibitors, additional biologic therapeutics, and hedgehog pathway inhibitors. Contains quick-access summaries of indications/contraindications, dosage guidelines, drug interactions, drug monitoring guidelines, adverse effects, and treatment protocols. Features a highly detailed, disease-specific index, as well as purchase information for major drugs. Helps you assess your knowledge and prepare for certification or recertification with about 800 review questions and answers throughout the book. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
(source: Nielsen Book Data)

• pt. I. Introduction
• pt. II. Important drug regulatory issues
• pt. III. Systemic drugs for infectious diseases
• pt. IV. Systemic immunomodulatory drugs
• pt. V. Drugs used in conjunction with UV or visible light
• pt. VI. Biological therapeutics
• pt. VII. Miscellaneous systemic drugs
• pt. VIII. Topical drugs for infectious diseases
• pt. IX. Topical immunomodulatory drugs
• pt. X. Miscellaneous topical drugs
• pt. XI. Injectable and mucosal routes of drug administration
• pt. XII. Major adverse effects from systemic drugs
• pt. XIII. Special pharmacology and therapeutic topics.

"Designed with practical usability in mind, Comprehensive Dermatologic Drug Therapy, 4th Edition, helps you safely and effectively treat the skin disorders you're likely to see in your practice. Dr. Stephen E. Wolverton and new associate editor Dr. Jashin J. Wu lead a team of global experts to bring you concise, complete guidance on today's full spectrum of topical, intralesional, and systemic drugs. You'll prescribe with confidence thanks to expert coverage of which drugs to use, when to use them, and adverse effects to monitor"--Publisher's description.

• Uncomplicated antepartum, intrapartum, and postpartum care
• Antepartum-intrapartum complications
• Perinatal substance abuse
• Adaptation to extrauterine life
• Neonatal delivery room resuscitation
• Thermoregulation
• Physical assessment
• Fluid and electrolyte management
• Glucose management
• Nutritional management
• Developmental support
• Pharmacology
• Laboratory testing in the NICU
• Radiologic evaluation
• Common invasive procedures
• P ain assessment and management
• Families in crisis
• Patient safety
• Discharge planning and transition to home
• Genetics: from bench to bedside
• Intrafacility and interfacility neonatal transport
• Care of the extremely low birth weight infant
• Care of the late preterm infant
• Respiratory distress
• Apnea
• Assisted ventilation
• Extracorporeal membrane oxygenation
• Cardiovascular disorders
• Gastrointestinal disorders
• Endocrine disorders
• Hematologic disorders
• Infectious diseases in the neonate
• Renal and genitourinary disorders
• Neurologic disorders
• Congenital anomalies
• Neonatal dermatology
• Ophthalmologic and auditory disorders
• Foundations of neonatal research
• Ethical issues
• Legal issues.

Perfect as a resource in the field or for exam preparation, this authoritative reference from the Association of Women's Health, Obstetric, and Neonatal Nurses (AWHONN) includes in-depth coverage of the most common neonatal disorders and their management. The concise outline format highlights the essentials of each condition including definition, etiology, pathophysiology, signs and symptoms, diagnostic tests, treatments, and outcomes to help you find important information quickly. This new edition also features an increased focus on evidence-based practice, new CAMTS and AAMS guidelines, new techniques for PICC placement, and changes to the Neonatal Resuscitation Program.