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• Introduction. Nonlinear regression models for individual data. Hierarchical linear models. Hierarchical nonlinear models. Inference based on individual estimates. Inference based on linearization. Nonperametric and semiparametric inference. Bayesian inference. Pharamcokinetic and pharamacodynamic analysis. Analysis of assay data. Further applications. Open problems and discussion. References. Indices.
• (source: Nielsen Book Data)

Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.
(source: Nielsen Book Data)

• Man the hunter
• Breakthrough to history
• Confluence of the civilized disease pools of Eurasia: 500 B.C. to A.D. 1200
• The impact of the Mongol Empire on shifting disease balances, 1200-1500
• Transoceanic exchanges, 1500-1700
• The ecological impact of medical science and organization since 1700.

• Ch. 1. History Katherine D. Watson, Philip Wexler, and Janet Everitt
• Ch. 2. Books and Special Documents Gerald L. kennedy, Jr.,... et. al.
• Ch. 3. Journals Philip Wexler
• Ch. 4. Newsletters P.J. (Bert) Hakkinen and Frederick W. Stoss
• Ch. 5. General Interest and Popular Works Frederick W. Stoss
• Ch. 6. Internet and Other Digital Resources Philip Wexler, P.J. (Bert) Hakkinen and Frederick W. Stoss
• Ch. 7. Print Bibliographic Resources Linda Miller Poore
• Ch. 8. Technical Reports and Government Documents Frederick W. Stoss
• Ch. 9. Publishers Linda Miller Poore and Tamara L.B. Wilson
• Ch. 10. Audiovisuals and Non-print Media Resources Frederick W. Stoss and Kathy Deck
• Ch. 11. Toxicology Data and Information Management Frederick W. Stoss and Philip Wexler

• Ch. 12. An Overview of U.S. Chemical and Environmental Control Laws and Regulations and Helpful Information Sources Maury Bandurraga
• Ch. 13. Regulation of Chemicals in the United States Maury Bandurraga
• Ch. 14. Resources for Hazard Communication Compliance Daniel marsick and Pat Dsida
• Ch. 15. Organizations P.J. (Bert) Hakkinen....et. al.
• Ch. 16. Education Society of Toxicology (SOT) and Society of Environmental Toxicology and Chemistry (SETAC)
• Ch. 17. Grants and Other Funding Opportunities Frederick W. Stoss and Philip wexler
• Ch. 18. Toxicology Testing Methods and Laboratories P.J. (Bert) Hakkinen
• Ch. 19. Poison Control Centers American Association of Poison Control Centers
• Ch. 20. Assessment of Physical Hazards P.J. (Bert) Hakkinen
• Ch. 21. Patents: Toxicological Information Resource Robert O. Beauchamp
• Ch. 22. Overwiew of International Activities C.E. Cowan-Ellsberry, M.J. Irwin, and C.C. Lally
• Ch. 23. International Register of potentially Toxic Chemicals National Correspondents International Register of Potentially Toxic Chemicals
• Ch. 24. Member Societies of the International Union of Toxicology (IUTOX) International Union of Toxicology
• Ch. 25. Countries: Canada/ Edmund M.k. lui, Catherine A.M. Suzuki, and John R. Bend. China / S. Li and D.Y. Zhu. Egypt / Laila A.M. Abd El-Megid and El-Sayed M. Salem. Finland / Hannu Komulainen.

• France / Jaques Descotes. Germany / Regine Kahl and Herbert Desel. India / Sushma Sharma, S.N. Agarwal and P.K Seth. italy / Paolo Preziosi, Adriana Dracos, and Ida Marcello

"Information Resources in Toxicology, Third Edition" is a sourcebook for anyone who needs to know where to find toxicology information. It provides an up-to-date selective guide to a large variety of sources - books, journals, organizations, audiovisuals, internet and electronic sources, and more. For the third edition, the editors have selected, organized, and updated the most relevant information available. New information on grants and other funding opportunities, physical hazards, patent literature, and technical reports have also been added. This comprehensive, time-saving tool is ideal for toxicologists, pharmacologists, drug companies, testing labs, libraries, poison control centers, physicians, legal and regulatory professionals, and chemists. Its key features are: it serves as an all-in-one resource for toxicology information; the new edition includes information on publishers, grants and other funding opportunities, physical hazards, patent literature, and technical reports; it is updated to include the latest internet and electronic sources, e-mail addresses, etc.; it provides valuable data about the new fields that have emerged within toxicological research, namely, the biochemical, cellular, molecular, and genetic aspects.
(source: Nielsen Book Data)

• I. A Cell's-eye View of Nourishment.
• 1. The Basics of Smart Nutrition. II. Smart Nutrition in Your Basic Food Categories.
• 2. Fruits and Vegetables.
• 3. Grains, Legumes, and Nuts.
• 4. Extracted Fats and Oils.
• 5. Meats, Fish, Poultry, and Eggs.
• 6. Dairy: Milk, Cheese, Ice Cream, and Yogurts. III. Special Features of Smart Nutrition.
• 7. Reading Between the Lines of Nutrition Labels.
• 8. To Supplement or Not to Supplement Is No Longer the Question.
• 9. Vegetarianism: Should You Move Towards a Plant-based Diet?
• 10. Dining Out: Smart Eating in Restaurants. IV. Nutrition Pitfalls.
• 11. Don't Let Bad Food Habits Cancel Fitness Benefits.
• 12. Sensible Weight Loss Versus Fad Diets.
• 13. Food Safety: Avoiding Foodborne Illness. V. Medical Issues.
• 14. Holistic Nutrition Against Cancer, Heart Disease, and Other Degenerative Diseases.
• 15. Dealing with Food Allergies. VI. The Art of Smart Nutrition.
• 16. Teen Health Starts in the Womb.
• 17. Nutrition Through the Ages: Young Adult to Golden Years. A. Glossary. B. Resource Guide. C. Recommended Reading List. D. Important Documents. E. Guides to Nutritional Quality Levels. Index.
• (source: Nielsen Book Data)

Everyone has heard that eating too much cholesterol and fat will lead to heart disease, that no matter how many diets Americans endure they are still overweight, that inappropriate food choices can lead to adult-onset diabetes, yet most people seem to have more and more difficulty meeting their bodies' nutritional needs. Clearly they are eating more, but they aren't eating smart. The Unofficial Guide to Smart Nutrition shows readers: What the USDA Food Pyramid reveals -- and what it doesn't Why frozen is better than canned but fresh is the best of all What the food industry doesn't want you to know about luncheon meats Why vitamin and mineral supplements can't rescue a poor diet Which chemicals in food may cause illness, and how to avoid carcinogens How to make a superior peanut butter and jelly sandwich.
(source: Nielsen Book Data)

• Health Effects of Low-level Exposure to Nerve Agents. Toxicokinetics of Nerve Agents. Low-level Nerve Agent Toxicity under Normal and Stressful Conditions. Blood-Brain Barrier Modulations and Low-level Exposure to Xenobiotics. Pharmacokinetics and Pharmacodynamics of Carbamates under Physical Stress. New Approaches to Medical Protection against Chemical Warfare Nerve Agents. Nerve Agent Bioscavengers: Protection against High and Low Dose Organophosphorus Exposure. Chronic Effects of Acute, Low-Level Exposure to the Chemical Warfare Agent Sulfur Mustard. Gulf War Syndrome: Questions, some Answers and the Future of Deployment Surveillance. Acute and Chronic Cyanide Toxicity. Toxins and Clinical Considerations. Psychological Factors in Chemical Warfare and Terrorism. Emergency Response to a Chemical Warfare Agent Incident: Domestic Preparedness, First Response, and Public Health Considerations.
• (source: Nielsen Book Data)

Many books cover the emergency response to chemical terrorism. But what happens after the initial crisis? Chlorine, phosgene, and mustard were used in World War I. Only years after the war were the long-term effects of these gases realized. In the 60s, 70s, and 80s, these and other agents were used in localized wars. Chemical Warfare Agents: Toxicity at Low Levels explores the long range effects of, protection against, and remedies for chemicals used during war and the chronic problems possibly resulting from toxic exposures during the Persian Gulf War.The book discusses the toxicities of chemical agents at low-levels. It focuses on the effects on military personnel after exposure to low levels of sarin - a chemical suspected to have been present during the Gulf War. It also covers factors such as stress, surrounding, and other chemicals that can enhance or decrease the toxicity of chemical warfare or protective agents. It discusses the effects of stress on the blood-brain permeability of pyrodostigmine and polar compounds, and describes how circulating scavenger enzymes or enzymes covalently bound to sponges can detoxify chemical agents.A cute toxicity is easy to observe and treat but low-level toxicity is difficult to identify - and can present and persist months and years after the initial exposure - making its treatment that much more difficult. Written by experts known for their contributions to the science of toxic chemicals, Chemical Warfare Agents: Toxicity at Low Levels gives you the latest information about the pathophysiology of chemical warfare agent injury at low concentrations.
(source: Nielsen Book Data)

An excellent critical analysis and scientific assessment of the nature and actual level of risk leading environmental health hazards pose to the public. Issues such as radiation from nuclear testing, radon in the home, and the connection between electromagnetic fields and cancer, environmental factors and asthma, pesticides and breast cancer and leukaemia clusters around nuclear plants are discussed and how scientists assesa these risks is illuminated. This book will enable readers to better understand environmental health issues and with the proper scientific understanding, make informed, rational decisions about them.
(source: Nielsen Book Data)

• 1. A Death in Devizes
• 2. Possessed
• 3. The Cannibal Disease
• 4. Neuro-Invasion
• 5. On the Trail of a Killer
• 6. Straining the Hypoothesis 7.Consuming Fears
• 8. The Human Toll
• 9. Blood Simple
• 10. Can It HappenHere?
• (source: Nielsen Book Data)

Prions are an entirely new class of pathogens, and scientists are just beginning to understand them. This book tells the strange story of their discovery, and the medical controversies that swirl around them.
(source: Nielsen Book Data)

• Disease in disguise
• Winged victories
• Food fright
• Superbugs
• Once and future pandemic
• Infection unmasked
• Bioterror
• Think locally, act globally.

So you think modern medicine has the whole virus game figured out? Think again. And ita (TM)s not even a question of a /ifa wea (TM)ll be hit by some new and deadly diseasea "ita (TM)s a /when.a The war on germs is being fought on many frontsa "from the skirmishes with disease-carrying mosquitoes that cross oceans hidden away in airline wheel wells to the high-profile battle against terrorists wielding deadly bioweapons. Todaya (TM)s bold headlines would have us believe that the biggest threat comes from bioterrorism. But dona (TM)t underestimate Mother Nature, perhaps the most savage bioterrorist of all. Assisted by the increasing ease with which peoplea "and the germs they carrya "move across international borders, shea (TM)s an effective force to be reckoned with, a key player on this battlefield. As author Madeline Drexler makes clear, wea (TM)d do best not to ignore her. Human beings and the pathogens that attack them are crossing paths more and more frequently, particularly as modern life grows increasingly complex. Whatever the infectious agent may be, whether ita (TM)s pandemic flu, foodborne illness, a debilitating disease carried far and wide by biting insects, or some new microbial horror we have yet to detect, keen surveillance and rapid response are really the only weapons in our arsenal. Secret Agents looks at todaya (TM)s new and emerging infectionsa "those that have increased in attack rate or geographic range, or threaten to do soa "and tells the stories of scientists racing to catch up with invisible adversaries superior in both speed and guile. Each chapter focuses on a different threat: foodborne pathogens, antibiotic resistance, animals and insectborne diseases, pandemic influenza, infectious causes of chronic disease, and bioterrorism, including the latest information on the public health threats posed by anthrax and diseases such as smallpox. Based in part on material collected from the Forum on Emerging Infections hosted by the Institute of Medicine in Washington, D.C., Secret Agents is ultimately as engaging as it is disturbing. Drexlera (TM)s thorough survey of the field of infectious disease, supplemented by extensive interviews with todaya (TM)s top researchers, yields a compelling portrait of a world engaged in a clandestine war. Emerging infections are among the many secret ties that bind the world into an organic whole. We know that infectious disease is an inescapable part of life, but we need to begin thinking globally and acting locally if we are to avoid the menace of a catastrophic outbreak of some new plague. Secret Agents sounds a clear and compelling call to take up arms against the organic predators among us.
(source: Nielsen Book Data)

The first edition of the "Encyclopedia of Biostatistics" proved an outstanding achievement in scientific publishing. A truly international work, its coverage ranges through statistical issues pertinent to life scientists, healthcare professionals and practising statisticians. Wiley is now pleased to announce the Second Edition of this landmark reference work publishing in February 2005. Drawing on the expertise of the original editorial team the new edition will be revised and expanded to provide, in particular, up-to-date material on bio-informatics and statistical genetics. This major publication is easily accessible for all those involved in statistical activities in medicine and health sciences, from health professionals who are not highly trained in statistics, through to fully qualified and experienced statisticians.Reviews of the First Edition: '...a resource beyond compare...the author index reads like a contemporary Who's Who...nothing in biostatistics is left uncovered...unsurpassed in quality and quantity' - "British Medical Journal". "An unsurpassed addition to the statistical literature ...The present scope of statistics in medical research is nowhere more manifest ...the coverage is breathtaking" - "International Journal of Epidemiology".
(source: Nielsen Book Data)

• Disclaimer V.- Acknowledgments.- Foreword by Lewis R. Goldfrank.- Introduction by Andrew Weil.- Authors? Note.-
• Section 1. Botanical Nomenclature and Botanical Glossary of Terms.- Botanical Nomenclature.- Glossary of Botanical Terms.-
• Section 2. Poisons, Poisoning Syndromes, and Their Clinical Management.-
• Section 3. Plant-Induced Dermatitis (Phytodermatitis).-
• Section 4. Gastrointestinal Decontamination.-
• Section 5. Individual Plants.- Photographers? Credits.- Index.
• (source: Nielsen Book Data)

In the 20 years that have passed since the publication of the first edition, both Poison Control Centers and Emergency Departments have witnessed an expansion in the number and variety of poisonings caused by toxic plants. At the same time, there is a proliferation in the diversity of plants in our gardens and homes, continually expanding the range of possible consequences from exposure to toxic plants. This second edition of the "Handbook of Poisonous and Injurious Plants" is created to assist the clinician in the initial response to the needs of a child or adult exposed to a poisonous or injurious plant. It lists common plants that might lead to the development of the symptom complex and describes the mechanisms of action of the implicated toxin, additional clinical manifestations, and specific therapeutics for each presentation. It has methodically enhanced the previous edition's botanical rigor with insights from both pharmacognosy and clinical medicine to make it a truly comprehensive source. With its thorough references and full-color photos of hundreds of potentially toxic and injurious plants inside the home, anyone who has an interest in plants will find this book useful outside in the garden or out in the wild. This book will fascinate botanists, horticulturists, and naturalists as well as hikers, gardeners, and all those who simply enjoy the wonders of nature and the great outdoors! It includes a foreword by Lewis R. Goldfrank, MD and an introduction by Andrew Weil, MD.
(source: Nielsen Book Data)

• Part I: From medicine to murder--
• Chapter 1: Ricin and the assassination of Georgi Markov--
• Chapter 2: Hyoscine and the murder of Belle Elmore--
• Chapter 3: Atropine and Mrs Agutter's gin and tonic--
• Chapter 4: Diamorphine and the Dr Jekyll of Hyde--
• Chapter 5: Adrenaline and the near-perfect murders of Kirsten Gilbert-- Part II: So simple, so useful, so deadly--
• Chapter 6: Chloroform and the murder of Edwin Bartlett--
• Chapter 7: Life & Death & CO-- Carbon monoxide and the homemade gas chamber--
• Chapter 8: Cyanide and the death on the Nile--
• Chapter 9: Paraquat and the poisoned gravy--
• Chapter 10: Polonium and the poisoning of Alexander Litvinenko--.
• (source: Nielsen Book Data)

Molecules of Murder is about infamous murderers and famous victims; about people like Harold Shipman, Alexander Litvinenko, Adelaide Bartlett, and Georgi Markov. Few books on poisons analyse these crimes from the viewpoint of the poison itself, doing so throws a new light on how the murders or attempted murders were carried out and ultimately how the perpetrators were uncovered and brought to justice. Part I includes molecules which occur naturally and were originally used by doctors before becoming notorious as murder weapons. Part II deals with unnatural molecules, mainly man-made, and they too have been dangerously misused in famous crimes. The book ends with the most famous poisoning case in recent years, that of Alexander Litvinenko and his death from polonium chloride. The first half of each chapter starts by looking at the target molecule itself, its discovery, its history, its chemistry, its use in medicine, its toxicology, and its effects on the human body. The second half then investigates a famous murder case and reveals the modus operandi of the poisoner and how some were caught, some are still at large, and some literally got away with murder. Molecules of Murder will explain how forensic chemists have developed cunning ways to detect minute traces of dangerous substances, and explain why some of these poisons, which appear so life-threatening, are now being researched as possible life-savers. Award winning science writer John Emsley has assembled another group of true crime and chemistry stories to rival those of his highly acclaimed Elements of Murder.
(source: Nielsen Book Data)

Each day, headlines warn that baby bottles are leaching dangerous chemicals, nonstick pans are causing infertility, and plastic containers are making us fat. What if green chemistry could change all that? What if rather than toxics, our economy ran on harmless, environmentally-friendly materials? Elizabeth Grossman, an acclaimed journalist who brought national attention to the contaminants hidden in computers and other high tech electronics, now tackles the hazards of ordinary consumer products. She shows that for the sake of convenience, efficiency, and short-term safety, we have created synthetic chemicals that fundamentally change, at a molecular level, the way our bodies work. The consequences range from diabetes to cancer, reproductive and neurological disorders. Yet it's hard to imagine life without the creature comforts current materials provide - and Grossman argues we do not have to. A scientific revolution is introducing products that are 'benign by design', developing manufacturing processes that consider health impacts at every stage, and is creating new compounds that mimic rather than disrupt natural systems. Through interviews with leading researchers, Grossman gives us a first look at this radical transformation. Green chemistry is just getting underway, but it offers hope that we can indeed create products that benefit health, the environment, and industry.
(source: Nielsen Book Data)

• Chapter 1: Introduction--
• Chapter 2: Control of Chemical Substances--
• Chapter 3: Nomenclature--
• Chapter 4: Drug Control at International and European Level--
• Chapter 5: Drug Legislation in the UK--
• Chapter 6: Generic Controls in the UK--
• Chapter 7: Natural Products - Problem Areas--
• Chapter 8: Other Problems of Chemical/Legal Interpretation--
• Chapter 9: Candidates for Future Control--
• Chapter 10: Generic and Analogue Control - International Comparisons--
• Chapter 11: The Drug Classification Debate--
• Chapter 12: The Future of "Substance" Legislation in the UK.
• (source: Nielsen Book Data)

This book builds on an earlier publication by the same author: The Misuse of Drugs Act: A Guide for Forensic Scientists. It provides a chemical background to the domestic and international legal controls on drugs of abuse and related substances and includes coverage of 'designer drugs' and generic/analogue controls from the UK, US and New Zealand perspectives. The content of the book has been fully updated and rearranged and the scope has been considerably expanded. More general chapters cover the recent history of the drug classification debate and a proposal for consolidating a wide range of legal controls on chemical substances. An account is provided of the Early Warning System on 'New Psychoactive Substances' in operation in the European Union. Technical and subsidiary material is placed in 20 Appendices, which list controlled substances and cover topics such as: precursor chemicals, related legislation, sentencing guidelines and detailed chemical/pharmacological profiles of the most commonly-abused drugs. There is a glossary and a bibliography, while extensive footnotes support the text and provide references to selected publications and Internet sources. The book contains a number of unique features, not found in any other single publication: * For the forensic scientist, the book contains a complete list of all drug substances controlled by UK and International law. It explains the chemical-structural definitions and the significance to the legislation of terms such as salt, base, stereoisomer, ester, ether, derivative, homologue and isotope * For the more general reader, there is an account of the history of domestic, European and International drugs control, the long debate about drug classification, the role of risk assessment and how the legal control of a wide range of harmful chemical substances might be consolidated * For the criminal lawyer, the book provides a useful adjunct to standard works on case and statute law This unique book has general appeal to anybody needing information on drugs of abuse including forensic scientists, researchers, teachers, criminal lawyers, customs officers, postgraduate and graduate students. It is of particular interest to those studying forensic science.
(source: Nielsen Book Data)

This new edition builds on the critical and commercial success of the first edition, published in 1993, and the second edition, published in 1999. With approximately 150 articles designed to provide accessibility to the widest possible readership, the title will remain a mainstay of the field for years to come. The new edition reflects developments within the field that have taken place since the second edition. These include: new information developed in the areas of both the fundamental and applied aspects of toxicology; considerable increase in the development of fundamental information and its applications, refinement of technical methods, advances in mechanistic toxicology, and greater interest in areas of toxicology previously regarded as of limited scope; and, changing approaches to methodological, interpretative, regulatory, and ethical aspects of basic and applied toxicology.
(source: Nielsen Book Data)

• Contributors. Preface. Preface to the Second Edition. Preface to the First Edition. Acknowledgments. Origins of Chapters. Introduction.
• SECTION I: BROAD CONCEPTS AND ANALYTIC TECHNIQUES.
• Chapter 1 Statistical Concepts Fundamental to Investigations ( Lincoln E. Moses ).
• Chapter 2 Some Uses of Statistical Thinking ( John C. Bailar III ).
• Chapter 3 Use of Statistical Analysis in the New England Journal of Medicine ( Shilpi Agarwal, Graham A. Colditz, and John D. Emerson ).
• SECTION II: DESIGN.
• Chapter 4 Randomized Trials and Other Parallel Comparisons of Treatment ( Nancy E. Mayo ).
• Chapter 5 Crossover and Self-Controlled Designs in Clinical Research ( John C. Bailar III, Thomas A. Louis, Philip W. Lavori, and Marcia Polansky ).
• Chapter 6 The Series of Consecutive Cases as a Device for Assessing Outcomes of Interventions (Lincoln E. Moses ).
• Chapter 7 Biostatistics in Epidemiology: Design and Basic Analysis ( Mark S. Goldberg ).
• SECTION III: ANALYSIS.
• Chapter 8 p -Values ( James H. Ware, Frederick Mosteller, Fernando Delgado, Christl Donnelly, and Joseph A. Ingelfinger ).
• Chapter 9 Understanding Analyses of Randomized Trials ( Nancy E. Mayo ).
• Chapter 10 Linear Regression in Medical Research ( Paul J. Rathouz and Amita Rastogi ).
• Chapter 11 Statistical Analysis of Survival Data ( Stephen W. Lagakos ).
• Chapter 12 Analysis of Categorical Data in Medical Studies ( Paul S. Albert ).
• Chapter 13 Analyzing Data from Ordered Categories ( Lincoln E. Moses, John D. Emerson, and Hossein Hosseini ).
• SECTION IV: COMMUNICATING RESULTS.
• Chapter 14 Guidelines for Statistical Reporting in Articles for Medical Journals: Amplifications and Explanations ( John C. Bailar III and Frederick Mosteller ).
• Chapter 15 Reporting of Subgroup Analyses in Clinical Trials ( Rui Wang, Stephen W. Lagakos, James H. Ware, David J. Hunter, and Jeffrey M. Drazen ).
• Chapter 16 Writing about Numbers ( Frederick Mosteller, Margaret Perkins, and Stephen Morrissey ).
• SECTION V: SPECIALIZED METHODS.
• Chapter 17 Combining Results from Independent Studies: Systematic Reviews and Meta-Analysis in Clinical Research ( Michael A. Stoto ).
• Chapter 18 Biostatistics in Epidemiology: Advanced Methods of Regression Analysis ( Mark S. Goldberg ).
• Chapter 19 Genetic Inference ( Dan L. Nicolae, Thorsten Kurz, and Carole Ober ).
• Chapter 20 Identifying Disease Genes in Association Studies ( Dan L. Nicolae, Thorsten Kurz, and Carole Ober ).
• Chapter 21 Risk Assessment ( A. John Bailer and John C. Bailar III ). INDEX.
• (source: Nielsen Book Data)

A new edition of the classic guide to the use of statistics in medicine, featuring examples from recent articles in the New England Journal of Medicine Medical Uses of Statistics has served as one of the most influential works on the subject for physicians, physicians-in-training, and a myriad of healthcare experts who need a clear idea of the proper application of statistical techniques in clinical studies as well as the implications of their interpretation for clinical practice. This Third Edition maintains the focus on the critical ideas, rather than the mechanics, to give practitioners and students the resources they need to understand the statistical methods they encounter in modern medical literature. Bringing together contributions from more than two dozen distinguished statisticians and medical doctors, this volume stresses the underlying concepts in areas such as randomized trials, survival analysis, genetics, linear regression, meta-analysis, and risk analysis. The Third Edition includes:* Numerous examples based on studies taken directly from the pages of the New England Journal of Medicine* Two added chapters on statistics in genetics* Two new chapters on the application of statistical methods to studies in epidemiology* New chapters on analyses of randomized trials, linear regression, categorical data analysis, meta-analysis, subgroup analyses, and risk analysis* Updated chapters on statistical thinking, crossover designs, p-values, survival analysis, and reporting research results* A focus on helping readers to critically interpret published results of clinical research Medical Uses of Statistics, Third Edition is a valuable resource for researchers and physicians working in any health-related field. It is also an excellent supplemental book for courses on medicine, biostatistics, and clinical research at the upper-undergraduate and graduate levels.
(source: Nielsen Book Data)

• v. 1. General principles / volume editor, James Bond
• v. 2. Cellular and molecular toxicology / volume editor, Kenneth Ramos
• v. 3. Toxicology testing and evaluation / volume editor, James Lamb
• v. 4. Biotransformation / volume editor, F. Peter Guengerich
• v. 5. Immune system toxicology / volume editor, David Lawrence
• v. 6. Cardiovascular toxicology / volume editors, Mary Walker and Matthew Campen
• v. 7. Renal toxicology / volume editor, Rick Schnellmann
• v. 8. Respiratory toxicology / volume editor, Garold S. Yost
• v. 9. Hepatic toxicology / volume editors, Robert A. Roth and Patricia Ganey
• v. 10. Gastrointestinal toxicology / volume editor, Stephen Hooser
• v. 11. Reproductive and endocrine toxicology / volume editors, John Richburg and Patricia Hoyer
• v. 12. Developmental toxicology / Thomas Knudsen and George Daston
• v. 13. Nervous system and behavioral toxicology / Martin Philbert
• v. 14. Carcinogenesis / volume editor, Ruth Roberts.

This is an explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume second edition of "Comprehensive Toxicology" has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. "Comprehensive Toxicology Second Edition" provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. "Comprehensive Toxicology Second Edition" is the most complete and valuable toxicology work available to researchers today. It includes contents updated and revised to reflect developments in toxicology research. It is organized with a unique organ-system approach. It features full color throughout. It is available electronically on website, as well as in a limited-edition print version.
(source: Nielsen Book Data)

• Preface
• Abbreviations and Glossary
• 1. Introduction: the basics - infections, transmission and models
• 2. How are models set up? I. An introduction to difference equations
• 3. How are models set up? II. An introduction to differential equations
• 4. What do models tell us about the dynamics of infections?
• 5. Age patterns
• 6. An introduction to stochastic modelling
• 7. How do models deal with contact patterns?
• 8. Sexually transmitted infections
• 9. Special topics in infectious disease modelling
• Appendix
• Basic maths
• Further reading
• Useful equations.
• (source: Nielsen Book Data)

Mathematical models are increasingly being used to examine questions in infectious disease control. Applications include predicting the impact of vaccination strategies against common infections and determining optimal control strategies against HIV and pandemic influenza. This book introduces individuals interested in infectious diseases to this exciting and expanding area. The mathematical level of the book is kept as simple as possible, which makes the book accessible to those who have not studied mathematics to university level. Understanding is further enhanced by models that can be accessed online, which will allow readers to explore the impact of different factors and control strategies, and further adapt and develop the models themselves. The book is based on successful courses developed by the authors at the London School of Hygiene and Tropical Medicine. It will be of interest to epidemiologists, public health researchers, policy makers, veterinary scientists, medical statisticians and infectious disease researchers.
(source: Nielsen Book Data)

• Molecular genetics
• Formal genetics
• Genetic markers
• Data quality
• Genetic map distances
• Family studies
• Twin and adoption studies
• Model-based linkage analysis
• Model-free linkage analysis
• Quantitative traits
• Fundamental concepts of association analyses
• Association analysis in unrelated individuals
• Family-based association analysis
• Haplotypes in association analyses
• Genome-wide Association (GWA) studies.

This is the second edition of the successful textbook written by the prize-winning scientist Andreas Ziegler, former President of the German Chapter of the International Biometric Society, and Inke Koenig, who has been teaching the subject over many years. The book gives a comprehensive introduction into the relevant statistical methods in genetic epidemiology. The second edition is thoroughly revised, partly rewritten and includes now chapters on segregation analysis, twin studies and estimation of heritability. The book is ideally suited for advanced students in epidemiology, genetics, statistics, bioinformatics and biomathematics. Like in the first edition the book contains many problems and solutions and it comes now optionally with an e-learning course created by Friedrich Pahlke. This e-learning course has been developed to complement the book. Both provide a unique support tool for teaching the subject.
(source: Nielsen Book Data)

• Disrupting hormonal signals
• Before World War II : chemicals, risk, and regulation
• Help for women over forty
• Bigger, stronger babies with diethylstilbestrol
• Modern meat : hormones in livestock
• Growing concerns
• Assessing new risks
• Sexual development and a new ecology of health
• Precaution and the lessons of history.

In 1941 the Food and Drug Administration approved the use of diethylstilbestrol (DES), the first synthetic chemical to be marketed as an estrogen and one of the first to be identified as a hormone disruptor-a chemical that mimics hormones. Although researchers knew that DES caused cancer and disrupted sexual development, doctors prescribed it for millions of women, initially for menopause and then for miscarriage, while farmers gave cattle the hormone to promote rapid weight gain. Its residues, and those of other chemicals, in the American food supply are changing the internal ecosystems of human, livestock, and wildlife bodies in increasingly troubling ways. In this gripping exploration, Nancy Langston shows how these chemicals have penetrated into every aspect of our bodies and ecosystems, yet the U.S. government has largely failed to regulate them and has skillfully manipulated scientific uncertainty to delay regulation. Personally affected by endocrine disruptors, Langston argues that the FDA needs to institute proper regulation of these commonly produced synthetic chemicals.
(source: Nielsen Book Data)